{"id":374,"date":"2024-11-13T03:22:49","date_gmt":"2024-11-13T03:22:49","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=374"},"modified":"2025-04-11T02:53:59","modified_gmt":"2025-04-11T02:53:59","slug":"genetic-testing-accuracy-limitations","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/genetic-testing-accuracy-limitations\/","title":{"rendered":"\u907a\u4f1d\u5b50\u60c5\u5831\u3067\u98df\u751f\u6d3b\u3092\u898b\u76f4\u3059\u65b9\u6cd5"},"content":{"rendered":"\n

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\n <\/p>\n
\n

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\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

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\n <\/p>\n
\n

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\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

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\n <\/p>\n
\n

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\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u60c5\u5831\u3068\u98df\u7fd2\u6163\u306e\u95a2\u9023\u6027<\/strong><\/h3>\n\n\n\n

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\n <\/p>\n
\n

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\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

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\n <\/p>\n
\n

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\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

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\"\u4f53\u91cd\u8a08\u306b\u4e57\u3063\u305f\u8db3\u5143\u3000\u30c0\u30a4\u30a8\u30c3\u30c8\u30a4\u30e1\u30fc\u30b8\"<\/figure>\n\n\n\n

\u907a\u4f1d\u5b50\u578b\u5225\u306e\u6700\u9069\u306a\u98df\u4e8b\u6cd5<\/strong><\/h3>\n\n\n\n

\u30c0\u30a4\u30a8\u30c3\u30c8\u306e\u6210\u529f\u7387\u306f\u3001\u500b\u4eba\u306e\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u5de6\u53f3\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001FTO\u907a\u4f1d\u5b50<\/strong>\uff08\u8102\u80aa\u84c4\u7a4d\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u70ad\u6c34\u5316\u7269\u306e\u6442\u53d6\u91cf\u3092\u6e1b\u3089\u3059\u3053\u3068\u3067\u3088\u308a\u52b9\u679c\u7684\u306b\u4f53\u91cd\u3092\u6e1b\u3089\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u9006\u306b\u3001\u8102\u8cea\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308bAPOA2\u907a\u4f1d\u5b50<\/strong>\u306b\u5909\u7570\u304c\u3042\u308b\u4eba\u306f\u3001\u9ad8\u8102\u80aa\u98df\u3092\u6442\u308b\u3068\u4f53\u91cd\u5897\u52a0\u3057\u3084\u3059\u3044\u305f\u3081\u3001\u4f4e\u8102\u80aa\u306e\u98df\u4e8b\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002 (diabetesjournals.org<\/a>)<\/p>\n\n\n\n

\u307e\u305f\u3001PPARG\u907a\u4f1d\u5b50<\/strong>\u306e\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u70ad\u6c34\u5316\u7269\u306e\u6442\u53d6\u3092\u9069\u5ea6\u306b\u5236\u9650\u3059\u308b\u3068\u8840\u7cd6\u5024\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u6539\u5584\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u4e00\u4eba\u3072\u3068\u308a\u306b\u5408\u3063\u305f\u6700\u9069\u306a\u98df\u4e8b\u30d7\u30e9\u30f3\u3092\u8a2d\u8a08\u3067\u304d\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u7cd6\u4ee3\u8b1d\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n

\u7cd6\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306e\u591a\u578b\u304c\u3001\u500b\u3005\u306e\u8840\u7cd6\u5024\u306e\u5909\u52d5\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001TCF7L2\u907a\u4f1d\u5b50<\/strong>\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u3001\u70ad\u6c34\u5316\u7269\u306e\u6442\u53d6\u91cf\u306b\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u578b\u306e\u4eba\u306f\u3001\u4f4eGI\u98df\u54c1\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u98df\u751f\u6d3b\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u8840\u7cd6\u5024\u306e\u5b89\u5b9a\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002 (nature.com<\/a>)<\/p>\n\n\n\n

\u307e\u305f\u3001SLC2A2\u907a\u4f1d\u5b50<\/strong>\uff08\u30b0\u30eb\u30b3\u30fc\u30b9\u8f38\u9001\u4f53\u306b\u95a2\u4e0e\uff09\u306b\u5909\u7570\u304c\u3042\u308b\u5834\u5408\u3001\u7cd6\u8cea\u306e\u5438\u53ce\u304c\u901a\u5e38\u3088\u308a\u3082\u65e9\u304f\u306a\u308b\u305f\u3081\u3001\u6025\u6fc0\u306a\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u3092\u9632\u3050\u305f\u3081\u306b\u3001\u98df\u7269\u7e4a\u7dad\u306e\u591a\u3044\u98df\u54c1\u3092\u6442\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u98df\u54c1\u9078\u3073<\/strong><\/h2>\n\n\n\n

\u4e73\u7cd6\u4e0d\u8010\u75c7\u3068LCT\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n

\u725b\u4e73\u3084\u4e73\u88fd\u54c1\u3092\u6442\u53d6\u3059\u308b\u3068\u304a\u8179\u3092\u58ca\u3057\u3084\u3059\u3044\u4eba\u306f\u3001LCT\u907a\u4f1d\u5b50<\/strong>\uff08\u30e9\u30af\u30bf\u30fc\u30bc\u9175\u7d20\u306e\u6d3b\u6027\u306b\u95a2\u4e0e\uff09\u306e\u591a\u578b\u304c\u5f71\u97ff\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u304c\u6d3b\u6027\u5316\u3057\u3066\u3044\u306a\u3044\u5834\u5408\u3001\u4e73\u7cd6\u3092\u9069\u5207\u306b\u5206\u89e3\u3067\u304d\u305a\u3001\u6d88\u5316\u4e0d\u826f\u3084\u8179\u75db\u3092\u5f15\u304d\u8d77\u3053\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u3088\u3046\u306a\u4eba\u306f\u3001\u4e73\u7cd6\u3092\u542b\u307e\u306a\u3044\u690d\u7269\u6027\u30df\u30eb\u30af\uff08\u30a2\u30fc\u30e2\u30f3\u30c9\u30df\u30eb\u30af\u3084\u8c46\u4e73\u306a\u3069\uff09\u3092\u9078\u629e\u3059\u308b\u304b\u3001\u4e73\u7cd6\u5206\u89e3\u9175\u7d20\u3092\u542b\u3080\u4e73\u88fd\u54c1\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u6d88\u5316\u306e\u8ca0\u62c5\u3092\u8efd\u6e1b\u3067\u304d\u307e\u3059\u3002 (gut.bmj.com<\/a>)<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u30ab\u30d5\u30a7\u30a4\u30f3\u4ee3\u8b1d\u3068CYP1A2\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n

\u30ab\u30d5\u30a7\u30a4\u30f3\u306e\u4ee3\u8b1d\u901f\u5ea6\u306f\u3001CYP1A2\u907a\u4f1d\u5b50<\/strong>\u306b\u3088\u3063\u3066\u6c7a\u307e\u308a\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u3092\u5206\u89e3\u3059\u308b\u901f\u5ea6\u304c\u9045\u304f\u3001\u5c11\u91cf\u3067\u3082\u9577\u6642\u9593\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u30ab\u30d5\u30a7\u30a4\u30f3\u306e\u4ee3\u8b1d\u304c\u9045\u3044\u4eba\u304c\u5927\u91cf\u306e\u30b3\u30fc\u30d2\u30fc\u3092\u6442\u53d6\u3059\u308b\u3068\u3001\u5fc3\u62cd\u6570\u306e\u4e0a\u6607\u3084\u7761\u7720\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3057\u3084\u3059\u304f\u306a\u308b\u305f\u3081\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u30ec\u30b9\u30b3\u30fc\u30d2\u30fc\u3084\u30cf\u30fc\u30d6\u30c6\u30a3\u30fc\u3092\u9078\u3076\u3053\u3068\u304c\u671b\u307e\u3057\u3044\u3067\u3057\u3087\u3046\u3002\u9006\u306b\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u4ee3\u8b1d\u304c\u901f\u3044\u4eba\u306f\u3001\u30b3\u30fc\u30d2\u30fc\u3092\u98f2\u3093\u3067\u3082\u5f71\u97ff\u3092\u53d7\u3051\u306b\u304f\u304f\u3001\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u5411\u4e0a\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 (jama.com<\/a>)<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u3068ALDH2\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\u65e5\u672c\u4eba\u3092\u542b\u3080\u30a2\u30b8\u30a2\u4eba\u306e\u591a\u304f\u306f\u3001ALDH2\u907a\u4f1d\u5b50<\/strong>\u306b\u5909\u7570\u3092\u6301\u3063\u3066\u304a\u308a\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u3092\u5206\u89e3\u3059\u308b\u80fd\u529b\u304c\u4f4e\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u578b\u306e\u4eba\u304c\u30a2\u30eb\u30b3\u30fc\u30eb\u3092\u6442\u53d6\u3059\u308b\u3068\u3001\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u304c\u4f53\u5185\u306b\u84c4\u7a4d\u3057\u3084\u3059\u304f\u3001\u9854\u304c\u8d64\u304f\u306a\u3063\u305f\u308a\u3001\u982d\u75db\u3084\u5410\u304d\u6c17\u3092\u5f15\u304d\u8d77\u3053\u3057\u305f\u308a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u305f\u3081\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3067ALDH2\u907a\u4f1d\u5b50\u306e\u72b6\u614b\u3092\u78ba\u8a8d\u3057\u3001\u81ea\u5206\u306b\u5408\u3063\u305f\u9069\u91cf\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u6442\u53d6\u3092\u5fc3\u304c\u3051\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002 (alcohol.org<\/a>)<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u9078\u3073\u65b9<\/strong><\/h2>\n\n\n\n

\u8449\u9178\u4ee3\u8b1d\u3068MTHFR\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n

MTHFR\u907a\u4f1d\u5b50<\/strong>\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u8449\u9178\u306e\u4ee3\u8b1d\u304c\u901a\u5e38\u3088\u308a\u3082\u4f4e\u4e0b\u3057\u3001\u8840\u4e2d\u306e\u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u5024\u304c\u4e0a\u6607\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u305f\u3081\u3001\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u8449\u9178\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\uff08\u7279\u306b\u30e1\u30c1\u30eb\u5316\u8449\u9178\uff09\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3067\u304d\u307e\u3059\u3002 (pubmed.ncbi.nlm.nih.gov<\/a>)<\/p>\n\n\n\n

\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3068FADS1\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n

FADS1\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u306e\u4f53\u5185\u5909\u63db\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001DHA\u3084EPA\u306e\u5408\u6210\u80fd\u529b\u304c\u4f4e\u3044\u305f\u3081\u3001\u9b5a\u3092\u5341\u5206\u306b\u6442\u53d6\u3059\u308b\u304b\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3067\u88dc\u3046\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u306f\u3001\u8133\u6a5f\u80fd\u306e\u7dad\u6301\u3084\u708e\u75c7\u306e\u6291\u5236\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u305f\u3081\u3001\u7279\u306b\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3068\u3088\u3044\u3067\u3057\u3087\u3046\u3002 (nutrition.org<\/a>)<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u672a\u6765\u306e\u6804\u990a\u7ba1\u7406<\/strong><\/h2>\n\n\n\n

\u907a\u4f1d\u5b50\u60c5\u5831\u306e\u6d3b\u7528\u306f\u3001\u5358\u306a\u308b\u98df\u751f\u6d3b\u306e\u898b\u76f4\u3057\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u500b\u5225\u5316\u533b\u7642\u3084\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30fb\u30cb\u30e5\u30fc\u30c8\u30ea\u30b7\u30e7\u30f3\u306e\u767a\u5c55\u306b\u3082\u3064\u306a\u304c\u308a\u307e\u3059\u3002\u4eca\u5f8c\u3001AI\u6280\u8853\u3068\u7d44\u307f\u5408\u308f\u305b\u305f\u7cbe\u5bc6\u306a\u6804\u990a\u30a2\u30c9\u30d0\u30a4\u30b9\u3084\u3001\u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u30b9\u30de\u30fc\u30c8\u98df\u54c1\u306e\u958b\u767a\u304c\u9032\u3080\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u5065\u5eb7\u7ba1\u7406\u304c\u53ef\u80fd\u306b\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6b63\u3057\u304f\u7406\u89e3\u3057\u3001\u81ea\u5206\u306b\u5408\u3063\u305f\u98df\u4e8b\u3084\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u9078\u629e\u3092\u884c\u3046\u3053\u3068\u304c\u3001\u5065\u5eb7\u9577\u5bff\u3078\u306e\u7b2c\u4e00\u6b69\u3068\u306a\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30b9\u30ea\u30fc\u30c8\u5411\u3051\u6804\u990a\u7ba1\u7406<\/strong><\/h2>\n\n\n\n
\"\u6642\u8a08\u3092\u898b\u306a\u304c\u3089\u8003\u3048\u308b\u7537\u6027\"<\/figure>\n\n\n\n

\u7b4b\u8089\u306e\u6210\u9577\u3068ACTN3\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n

\u30b9\u30dd\u30fc\u30c4\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306b\u306f\u3001\u7b4b\u8089\u306e\u30bf\u30a4\u30d7\u3084\u4ee3\u8b1d\u52b9\u7387\u304c\u5927\u304d\u304f\u5f71\u97ff\u3057\u307e\u3059\u3002ACTN3\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u901f\u7b4b\u7e4a\u7dad\uff08\u7206\u767a\u7684\u306a\u529b\u3092\u767a\u63ee\u3059\u308b\u7b4b\u8089\uff09\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u306b\u3088\u3063\u3066\u3001\u30d1\u30ef\u30fc\u7cfb\u7af6\u6280\u306b\u5411\u3044\u3066\u3044\u308b\u304b\u3001\u6301\u4e45\u7cfb\u7af6\u6280\u306b\u5411\u3044\u3066\u3044\u308b\u304b\u304c\u5206\u304b\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u4f8b\u3048\u3070\u3001ACTN3 R577X<\/strong>\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u901f\u7b4b\u306e\u767a\u9054\u304c\u5236\u9650\u3055\u308c\u3084\u3059\u304f\u3001\u30de\u30e9\u30bd\u30f3\u3084\u9577\u8ddd\u96e2\u8d70\u306e\u3088\u3046\u306a\u6301\u4e45\u529b\u3092\u5fc5\u8981\u3068\u3059\u308b\u30b9\u30dd\u30fc\u30c4\u306b\u5411\u3044\u3066\u3044\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u4e00\u65b9\u3001RR\u578b<\/strong>\u306e\u4eba\u306f\u901f\u7b4b\u306e\u767a\u9054\u304c\u4fc3\u9032\u3055\u308c\u308b\u305f\u3081\u3001\u77ed\u8ddd\u96e2\u8d70\u3084\u30a6\u30a7\u30a4\u30c8\u30ea\u30d5\u30c6\u30a3\u30f3\u30b0\u306e\u3088\u3046\u306a\u7206\u767a\u7684\u306a\u529b\u3092\u5fc5\u8981\u3068\u3059\u308b\u30b9\u30dd\u30fc\u30c4\u306b\u5411\u3044\u3066\u3044\u307e\u3059\u3002 (sportsmedres.org<\/a>)<\/p>\n\n\n\n

\u3053\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u3082\u3068\u306b\u3001\u30a2\u30b9\u30ea\u30fc\u30c8\u306f\u6700\u9069\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u65b9\u6cd5\u3092\u9078\u629e\u3057\u3001\u98df\u4e8b\u306e\u5185\u5bb9\u3092\u8abf\u6574\u3059\u308b\u3053\u3068\u3067\u3001\u7af6\u6280\u529b\u5411\u4e0a\u3092\u76ee\u6307\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3068PPARGC1A\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n

\u6301\u4e45\u529b\u306e\u5411\u4e0a\u306b\u306f\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u52b9\u7387\u7684\u306a\u5229\u7528\u304c\u6b20\u304b\u305b\u307e\u305b\u3093\u3002PPARGC1A\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u3092\u8abf\u7bc0\u3057\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306b\u5927\u304d\u304f\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u8102\u80aa\u306e\u71c3\u713c\u52b9\u7387\u304c\u9ad8\u3044\u305f\u3081\u3001\u9577\u6642\u9593\u306e\u904b\u52d5\u306b\u9069\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u6301\u4e45\u7cfb\u30b9\u30dd\u30fc\u30c4\u9078\u624b\u306f\u3001PPARGC1A\u306e\u907a\u4f1d\u5b50\u578b\u3092\u57fa\u306b\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u3068\u3057\u3066\u70ad\u6c34\u5316\u7269\u3068\u8102\u8cea\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u8abf\u6574\u3057\u3001\u7af6\u6280\u306b\u9069\u3057\u305f\u6804\u990a\u30d7\u30e9\u30f3\u3092\u69cb\u7bc9\u3067\u304d\u307e\u3059\u3002 (sciencedirect.com<\/a>)<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u56de\u5fa9\u529b\u3068IL6\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n

\u904b\u52d5\u5f8c\u306e\u56de\u5fa9\u306b\u306f\u3001\u708e\u75c7\u53cd\u5fdc\u306e\u5236\u5fa1\u304c\u91cd\u8981\u3067\u3059\u3002IL6\u907a\u4f1d\u5b50<\/strong>\u306f\u708e\u75c7\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f36\u306e\u5206\u6ccc\u306b\u95a2\u4e0e\u3057\u3001\u7b4b\u8089\u306e\u4fee\u5fa9\u3084\u514d\u75ab\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002IL6\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u708e\u75c7\u53cd\u5fdc\u304c\u5f37\u304f\u51fa\u3084\u3059\u304f\u3001\u904e\u5ea6\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306b\u3088\u308b\u7b4b\u8089\u640d\u50b7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u907a\u4f1d\u5b50\u578b\u306e\u4eba\u306f\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3092\u6301\u3064\u98df\u54c1\uff08\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3084\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3092\u542b\u3080\u98df\u54c1\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3057\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u5f8c\u306e\u56de\u5fa9\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002 (journals.physiology.org<\/a>)<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u3068\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\uff1a\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u306e\u500b\u5225\u5316<\/strong><\/h2>\n\n\n\n

\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3068COMT\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n
\"\u60a9\u3080\u7537\u5973\"<\/figure>\n\n\n\n

\u30b9\u30c8\u30ec\u30b9\u306e\u611f\u3058\u3084\u3059\u3055\u3084\u51e6\u7406\u80fd\u529b\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3082\u5f71\u97ff\u3055\u308c\u307e\u3059\u3002COMT\u907a\u4f1d\u5b50<\/strong>\u306f\u30c9\u30fc\u30d1\u30df\u30f3\u306e\u5206\u89e3\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u306b\u3088\u3063\u3066\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306e\u500b\u4eba\u5dee\u304c\u751f\u3058\u307e\u3059\u3002<\/p>\n\n\n\n

\u4f8b\u3048\u3070\u3001Met\/Met\u578b<\/strong>\u306e\u4eba\u306f\u30c9\u30fc\u30d1\u30df\u30f3\u306e\u5206\u89e3\u304c\u9045\u3044\u305f\u3081\u3001\u96c6\u4e2d\u529b\u304c\u6301\u7d9a\u3057\u3084\u3059\u3044\u4e00\u65b9\u3067\u3001\u30b9\u30c8\u30ec\u30b9\u3092\u5f37\u304f\u611f\u3058\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u9006\u306b\u3001Val\/Val\u578b<\/strong>\u306e\u4eba\u306f\u30c9\u30fc\u30d1\u30df\u30f3\u306e\u5206\u89e3\u304c\u901f\u304f\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u306f\u5f37\u3044\u3082\u306e\u306e\u3001\u96c6\u4e2d\u529b\u304c\u9014\u5207\u308c\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002 (ncbi.nlm.nih.gov<\/a>)<\/p>\n\n\n\n

\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u57fa\u306b\u3001\u30b9\u30c8\u30ec\u30b9\u30de\u30cd\u30b8\u30e1\u30f3\u30c8\u306e\u65b9\u6cd5\u3092\u30ab\u30b9\u30bf\u30de\u30a4\u30ba\u3057\u3001\u9069\u5207\u306a\u98df\u4e8b\u3084\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u9078\u629e\u3092\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u30bb\u30ed\u30c8\u30cb\u30f3\u5206\u6ccc\u30685-HTTLPR\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n

\u30bb\u30ed\u30c8\u30cb\u30f3\u306f\u5e78\u798f\u611f\u3084\u30ea\u30e9\u30c3\u30af\u30b9\u306b\u95a2\u4e0e\u3059\u308b\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3067\u3042\u308a\u3001\u305d\u306e\u5206\u6ccc\u91cf\u306f5-HTTLPR\u907a\u4f1d\u5b50<\/strong>\u306b\u3088\u3063\u3066\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306eS\u578b\u30d0\u30ea\u30a2\u30f3\u30c8<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u5206\u6ccc\u91cf\u304c\u5c11\u306a\u304f\u3001\u30b9\u30c8\u30ec\u30b9\u3084\u4e0d\u5b89\u3092\u611f\u3058\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u907a\u4f1d\u5b50\u578b\u306e\u4eba\u306f\u3001\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3\u3092\u591a\u304f\u542b\u3080\u98df\u54c1\uff08\u30d0\u30ca\u30ca\u3001\u30ca\u30c3\u30c4\u3001\u5927\u8c46\u88fd\u54c1\u306a\u3069\uff09\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u751f\u6210\u3092\u4fc3\u9032\u3057\u3001\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 (cambridge.org<\/a>)<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u672a\u6765\u306e\u5065\u5eb7\u7ba1\u7406<\/strong><\/h2>\n\n\n\n

AI\u3068\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u306e\u7d71\u5408<\/strong><\/h3>\n\n\n\n

\u8fd1\u5e74\u3001AI\u3092\u6d3b\u7528\u3057\u305f\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u306e\u89e3\u6790\u6280\u8853\u304c\u6025\u901f\u306b\u767a\u5c55\u3057\u3066\u3044\u307e\u3059\u3002\u500b\u4eba\u306e\u907a\u4f1d\u60c5\u5831\u3068\u5065\u5eb7\u30c7\u30fc\u30bf\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001AI\u306f\u6700\u9069\u306a\u6804\u990a\u8a08\u753b\u3084\u75be\u75c5\u4e88\u9632\u6226\u7565\u3092\u63d0\u6848\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u4f8b\u3048\u3070\u3001\u30c7\u30a3\u30fc\u30d7\u30e9\u30fc\u30cb\u30f3\u30b0\u3092\u6d3b\u7528\u3057\u305f\u907a\u4f1d\u5b50\u89e3\u6790\u30c4\u30fc\u30eb\u306f\u3001\u7279\u5b9a\u306e\u75c5\u6c17\u306e\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3057\u3001\u305d\u308c\u306b\u57fa\u3065\u3044\u305f\u98df\u4e8b\u30d7\u30e9\u30f3\u3092\u500b\u5225\u306b\u63d0\u6848\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002\u5c06\u6765\u7684\u306b\u306f\u3001\u30b9\u30de\u30fc\u30c8\u30d5\u30a9\u30f3\u306e\u30a2\u30d7\u30ea\u3068\u9023\u643a\u3057\u305f\u300c\u907a\u4f1d\u5b50\u30d9\u30fc\u30b9\u306e\u6804\u990a\u30b3\u30f3\u30b5\u30eb\u30c6\u30a3\u30f3\u30b0\u300d\u304c\u4e00\u822c\u5316\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 (sciencedirect.com<\/a>)<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3068\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30fb\u30cb\u30e5\u30fc\u30c8\u30ea\u30b7\u30e7\u30f3<\/strong><\/h3>\n\n\n\n

CRISPR\u6280\u8853\u306e\u767a\u5c55\u306b\u3088\u308a\u3001\u5c06\u6765\u7684\u306b\u306f\u907a\u4f1d\u5b50\u7de8\u96c6\u306b\u3088\u308b\u6804\u990a\u4ee3\u8b1d\u306e\u6700\u9069\u5316\u304c\u53ef\u80fd\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u4f8b\u3048\u3070\u3001\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba\u306e\u907a\u4f1d\u5b50\u3092\u5fae\u8abf\u6574\u3057\u3001\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3092\u6539\u5584\u3059\u308b\u6280\u8853\u304c\u958b\u767a\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001\u98df\u6750\u305d\u306e\u3082\u306e\u3092\u500b\u4eba\u306e\u907a\u4f1d\u5b50\u306b\u6700\u9069\u5316\u3059\u308b\u6280\u8853\u3082\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u3044\u3066\u6804\u990a\u5f37\u5316\u3055\u308c\u305f\u98df\u54c1\u3092\u8a2d\u8a08\u3057\u3001\u7279\u5b9a\u306e\u5065\u5eb7\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba\u3005\u304c\u52b9\u7387\u7684\u306b\u6804\u990a\u3092\u6442\u53d6\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308b\u3067\u3057\u3087\u3046\u3002 (genomeweb.com<\/a>)<\/p>\n\n\n\n

\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u98df\u751f\u6d3b\u306e\u6700\u9069\u5316\u306f\u3001\u5358\u306a\u308b\u6804\u990a\u7ba1\u7406\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u533b\u7642\u3084\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u3042\u3089\u3086\u308b\u5074\u9762\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u5bfe\u7b56<\/strong><\/h2>\n\n\n\n
\"\n\u80a9\u304c\u304b\u3086\u3044\u5973\u6027\"<\/figure>\n\n\n\n

\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u3068HLA\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n

\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306f\u514d\u75ab\u7cfb\u306e\u904e\u5270\u53cd\u5fdc\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u304c\u3001\u305d\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306b\u306f\u907a\u4f1d\u7684\u8981\u56e0\u304c\u5927\u304d\u304f\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001HLA\uff08\u30d2\u30c8\u767d\u8840\u7403\u6297\u539f\uff09\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u514d\u75ab\u7cfb\u304c\u7570\u7269\u3092\u8a8d\u8b58\u3059\u308b\u969b\u306e\u9375\u3068\u306a\u308b\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u7279\u5b9a\u306eHLA\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u7279\u5b9a\u306e\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u767a\u75c7\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u4f8b\u3048\u3070\u3001HLA-DQ2\u3084HLA-DQ8\u3092\u6301\u3064\u4eba\u306f\u3001\u5c0f\u9ea6\u306b\u542b\u307e\u308c\u308b\u30b0\u30eb\u30c6\u30f3\u306b\u5bfe\u3059\u308b\u514d\u75ab\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3057\u3084\u3059\u304f\u3001**\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\uff08\u30b0\u30eb\u30c6\u30f3\u4e0d\u8010\u75c7\uff09**\u3092\u767a\u75c7\u3057\u3084\u3059\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u628a\u63e1\u3059\u308b\u3053\u3068\u3067\u3001\u98df\u4e8b\u304b\u3089\u7279\u5b9a\u306e\u30a2\u30ec\u30eb\u30b2\u30f3\u3092\u9664\u5916\u3057\u3001\u75c7\u72b6\u306e\u767a\u751f\u3092\u9632\u3050\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002 (nature.com<\/a>)<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u82b1\u7c89\u75c7\u3068IL13\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n

\u82b1\u7c89\u75c7\u306f\u74b0\u5883\u8981\u56e0\u3060\u3051\u3067\u306a\u304f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3082\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002IL13\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3059\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-13\uff08IL-13\uff09\u306e\u751f\u6210\u306b\u95a2\u4e0e\u3057\u3001\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u82b1\u7c89\u75c7\u306b\u306a\u308a\u3084\u3059\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u907a\u4f1d\u5b50\u578b\u306e\u4eba\u306f\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3092\u6301\u3064\u6804\u990a\u7d20\uff08\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3001\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3001\u30d3\u30bf\u30df\u30f3D\u306a\u3069\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75c7\u72b6\u3092\u8efd\u6e1b\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 (bmj.com<\/a>)<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0<\/strong><\/h2>\n\n\n\n

\u8001\u5316\u3068SIRT1\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n

SIRT1\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u300c\u9577\u5bff\u907a\u4f1d\u5b50\u300d\u3068\u3082\u547c\u3070\u308c\u308b\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u907a\u4f1d\u5b50\u306e\u4e00\u3064\u3067\u3001\u7d30\u80de\u306e\u4fee\u5fa9\u3084\u4ee3\u8b1d\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u304c\u6d3b\u6027\u5316\u3059\u308b\u3068\u3001\u8001\u5316\u306e\u9032\u884c\u304c\u6291\u3048\u3089\u308c\u3001\u5065\u5eb7\u5bff\u547d\u306e\u5ef6\u9577\u306b\u5bc4\u4e0e\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

SIRT1\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u306b\u306f\u3001**\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\uff08\u8d64\u30ef\u30a4\u30f3\u3084\u30d6\u30c9\u30a6\u306b\u542b\u307e\u308c\u308b\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff09**\u3092\u6442\u53d6\u3057\u305f\u308a\u3001\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u3092\u884c\u3046\u3053\u3068\u304c\u6709\u52b9\u3067\u3042\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 (cell.com<\/a>)<\/p>\n\n\n\n

\u307e\u305f\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\uff08\u30d3\u30bf\u30df\u30f3B3\uff09\u3084NMN\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30e2\u30ce\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff09\u306a\u3069\u306e\u88dc\u52a9\u56e0\u5b50\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u3001\u52a0\u9f62\u306b\u3088\u308b\u4ee3\u8b1d\u4f4e\u4e0b\u3092\u9632\u3050\u3053\u3068\u304c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u7d2b\u5916\u7dda\u306b\u3088\u308b\u76ae\u819a\u8001\u5316\u3068MC1R\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n

\u808c\u306e\u8001\u5316\u306b\u306f\u7d2b\u5916\u7dda\uff08UV\uff09\u306e\u5f71\u97ff\u304c\u5927\u304d\u3044\u3067\u3059\u304c\u3001MC1R\u907a\u4f1d\u5b50<\/strong>\uff08\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\uff09\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u306b\u3088\u3063\u3066\u3001\u7d2b\u5916\u7dda\u3078\u306e\u611f\u53d7\u6027\u304c\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

MC1R\u306e\u7279\u5b9a\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u30e1\u30e9\u30cb\u30f3\u306e\u751f\u6210\u91cf\u304c\u5c11\u306a\u304f\u3001\u7d2b\u5916\u7dda\u306b\u3088\u308bDNA\u640d\u50b7\u3092\u53d7\u3051\u3084\u3059\u3044\u305f\u3081\u3001\u65e5\u713c\u3051\u3057\u3084\u3059\u304f\u3001\u30b7\u30df\u3084\u30b7\u30ef\u304c\u3067\u304d\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u578b\u306e\u4eba\u306f\u3001**\u65e5\u713c\u3051\u6b62\u3081\u306e\u4f7f\u7528\u3092\u5fb9\u5e95\u3057\u3001\u6297\u9178\u5316\u4f5c\u7528\u306e\u3042\u308b\u98df\u54c1\uff08\u30d3\u30bf\u30df\u30f3C\u3001\u30d3\u30bf\u30df\u30f3E\u3001\u30a2\u30b9\u30bf\u30ad\u30b5\u30f3\u30c1\u30f3\u306a\u3069\uff09**\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002 (sciencedirect.com<\/a>)<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u8178\u5185\u74b0\u5883\u306e\u6539\u5584<\/strong><\/h2>\n\n\n\n
\"\u30e8\u30fc\u30b0\u30eb\u30c8\"<\/figure>\n\n\n\n

\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u3068FUT2\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n

\u8178\u5185\u74b0\u5883\u306e\u72b6\u614b\u306f\u3001\u6d88\u5316\u5438\u53ce\u3084\u514d\u75ab\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u304c\u3001\u305d\u306e\u30d0\u30e9\u30f3\u30b9\u306b\u306f\u907a\u4f1d\u5b50\u3082\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002FUT2\u907a\u4f1d\u5b50<\/strong>\uff08\u30d5\u30b3\u30fc\u30b9\u8ee2\u79fb\u9175\u7d202\uff09\u306f\u3001\u8178\u5185\u7d30\u83cc\u306e\u7d44\u6210\u3092\u6c7a\u5b9a\u3059\u308b\u8981\u56e0\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\u306e\u5b9a\u7740\u304c\u96e3\u3057\u3044<\/strong>\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u907a\u4f1d\u5b50\u578b\u306e\u4eba\u306f\u3001\u8178\u5185\u7d30\u83cc\u3092\u5897\u3084\u3059\u305f\u3081\u306b\u3001**\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u30e8\u30fc\u30b0\u30eb\u30c8\u3001\u767a\u9175\u98df\u54c1\uff09\u3084<\/strong>\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u98df\u7269\u7e4a\u7dad\u3001\u30aa\u30ea\u30b4\u7cd6\uff09**\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3068\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u3092\u6539\u5584\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002 (gut.bmj.com<\/a>)<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u8178\u5185\u767a\u9175\u3068LCT\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n

LCT\u907a\u4f1d\u5b50\uff08\u30e9\u30af\u30bf\u30fc\u30bc\u907a\u4f1d\u5b50\uff09\u306f\u3001\u4e73\u7cd6\u306e\u6d88\u5316\u80fd\u529b\u3092\u6c7a\u5b9a\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u4e73\u7cd6\u4e0d\u8010\u75c7<\/strong>\u306b\u306a\u308a\u3084\u3059\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u578b\u306e\u4eba\u304c\u4e73\u88fd\u54c1\u3092\u6442\u53d6\u3059\u308b\u3068\u3001\u8178\u5185\u3067\u904e\u5270\u306a\u767a\u9175\u304c\u8d77\u3053\u308a\u3001\u30ac\u30b9\u3084\u8179\u75db\u3001\u4e0b\u75e2\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u305f\u3081\u3001LCT\u907a\u4f1d\u5b50\u306b\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u4e73\u7cd6\u3092\u542b\u307e\u306a\u3044\u4ee3\u66ff\u98df\u54c1\uff08\u30a2\u30fc\u30e2\u30f3\u30c9\u30df\u30eb\u30af\u3001\u8c46\u4e73\uff09\u3092\u9078\u3093\u3060\u308a\u3001\u30e9\u30af\u30bf\u30fc\u30bc\u3092\u88dc\u3046\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u60c5\u5831\u3068\u672a\u6765\u306e\u533b\u7642<\/strong><\/h2>\n\n\n\n

\u907a\u4f1d\u5b50\u60c5\u5831\u306e\u6d3b\u7528\u306f\u3001\u5f93\u6765\u306e\u98df\u4e8b\u7ba1\u7406\u3084\u5065\u5eb7\u7ba1\u7406\u3092\u6839\u672c\u7684\u306b\u5909\u3048\u308b\u53ef\u80fd\u6027\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002AI\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u6804\u990a\u6307\u5c0e\u3084\u3001\u907a\u4f1d\u5b50\u578b\u306b\u6700\u9069\u5316\u3055\u308c\u305f\u98df\u54c1\u306e\u958b\u767a\u304c\u9032\u3080\u3053\u3068\u3067\u3001\u5c06\u6765\u7684\u306b\u306f\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u5065\u5eb7\u7ba1\u7406\u304c\u53ef\u80fd\u306b\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u98df\u4e8b\u3084\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u304c\u907a\u4f1d\u5b50\u767a\u73fe\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u8a73\u7d30\u306b\u89e3\u6790\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308c\u3070\u3001\u500b\u3005\u306e\u4f53\u8cea\u306b\u5408\u308f\u305b\u305f\u5b8c\u5168\u306a\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30fb\u30cb\u30e5\u30fc\u30c8\u30ea\u30b7\u30e7\u30f3\u304c\u5b9f\u73fe\u3059\u308b\u65e5\u3082\u8fd1\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002 (sciencedirect.com<\/a>)<\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306b\u5065\u5eb7\u3092\u7ba1\u7406\u3057\u3001\u9577\u5bff\u3084\u75c5\u6c17\u4e88\u9632\u306b\u5f79\u7acb\u3066\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u7761\u7720\u6539\u5584<\/strong><\/h2>\n\n\n\n

\u7761\u7720\u306e\u8cea\u3068CLOCK\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n

\u7761\u7720\u30ea\u30ba\u30e0\u306f\u3001\u4f53\u5185\u6642\u8a08\u3092\u8abf\u7bc0\u3059\u308b\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4e2d\u3067\u3082\u3001CLOCK\u907a\u4f1d\u5b50<\/strong>\u306f\u6982\u65e5\u30ea\u30ba\u30e0\uff08\u30b5\u30fc\u30ab\u30c7\u30a3\u30a2\u30f3\u30ea\u30ba\u30e0\uff09\u306b\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u306b\u3088\u3063\u3066\u671d\u578b\u304b\u591c\u578b\u304b\u304c\u6c7a\u307e\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u7279\u5b9a\u306eCLOCK\u907a\u4f1d\u5b50\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u591c\u66f4\u304b\u3057\u3057\u3084\u3059\u304f\u3001\u7761\u7720\u306e\u8cea\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u578b\u306e\u4eba\u306f\u3001\u591c\u9593\u306e\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\u3092\u907f\u3051\u308b\u3001\u30e1\u30e9\u30c8\u30cb\u30f3\u3092\u5897\u3084\u3059\u98df\u54c1\uff08\u30ca\u30c3\u30c4\u985e\u3084\u30d0\u30ca\u30ca\uff09\u3092\u6442\u53d6\u3059\u308b<\/strong>\u306a\u3069\u306e\u5bfe\u7b56\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u7761\u7720\u306e\u8cea\u3092\u6539\u5584\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 (nature.com<\/a>)<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u30ab\u30d5\u30a7\u30a4\u30f3\u611f\u53d7\u6027\u3068\u7761\u7720\u3078\u306e\u5f71\u97ff<\/strong><\/h3>\n\n\n\n
\"\u82b3\u9187\u306a\u9999\u308a\u304c\u6f02\u3046\u30b3\u30fc\u30d2\u30fc4\"<\/figure>\n\n\n\n

\u30ab\u30d5\u30a7\u30a4\u30f3\u306e\u4ee3\u8b1d\u901f\u5ea6\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u3001\u305d\u308c\u3092\u6c7a\u5b9a\u3059\u308b\u306e\u304cCYP1A2\u907a\u4f1d\u5b50<\/strong>\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u306e\u5206\u89e3\u304c\u9045\u304f\u3001\u5915\u65b9\u4ee5\u964d\u306b\u30b3\u30fc\u30d2\u30fc\u3092\u6442\u53d6\u3059\u308b\u3068\u3001\u591c\u306e\u7761\u7720\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u907a\u4f1d\u5b50\u578b\u306e\u4eba\u306f\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u30ec\u30b9\u306e\u98f2\u6599\u3092\u9078\u3076\u304b\u3001\u5348\u5f8c\u306e\u65e9\u3044\u6642\u9593\u307e\u3067\u306b\u30b3\u30fc\u30d2\u30fc\u306e\u6442\u53d6\u3092\u7d42\u3048\u308b\u3053\u3068\u3067\u3001\u7761\u7720\u306e\u8cea\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 (sleepfoundation.org<\/a>)<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u8840\u5727\u7ba1\u7406<\/strong><\/h2>\n\n\n\n

\u9ad8\u8840\u5727\u30ea\u30b9\u30af\u3068ACE\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n

ACE\u907a\u4f1d\u5b50<\/strong>\uff08\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d20\u907a\u4f1d\u5b50\uff09\u306f\u3001\u8840\u5727\u306e\u8abf\u6574\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u9ad8\u8840\u5727\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

ACE\u907a\u4f1d\u5b50\u306e\u30ea\u30b9\u30af\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u5869\u5206\u306e\u6442\u53d6\u3092\u63a7\u3048\u3081\u306b\u3057\u3001\u30ab\u30ea\u30a6\u30e0\u3092\u591a\u304f\u542b\u3080\u98df\u54c1\uff08\u30d0\u30ca\u30ca\u3001\u307b\u3046\u308c\u3093\u8349\uff09\u3092\u6442\u53d6\u3059\u308b<\/strong>\u3053\u3068\u3067\u3001\u8840\u5727\u3092\u9069\u5207\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002 (ncbi.nlm.nih.gov<\/a>)<\/p>\n\n\n\n

\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u4eba\u306e\u4f53\u8cea\u306b\u9069\u3057\u305f\u98df\u4e8b\u3084\u751f\u6d3b\u7fd2\u6163\u3092\u9078\u629e\u3057\u3001\u5065\u5eb7\u7dad\u6301\u306b\u5f79\u7acb\u3066\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u307e\u3068\u3081<\/strong><\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u3005\u306e\u4f53\u8cea\u306b\u6700\u9069\u306a\u98df\u751f\u6d3b\u3084\u5065\u5eb7\u7ba1\u7406\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u6804\u990a\u306e\u4ee3\u8b1d\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u30ea\u30b9\u30af\u3001\u7761\u7720\u306e\u8cea\u3001\u8840\u5727\u7ba1\u7406\u306a\u3069\u3001\u591a\u304f\u306e\u5065\u5eb7\u8981\u56e0\u306f\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u5f71\u97ff\u3092\u53d7\u3051\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u578b\u306b\u3088\u3063\u3066\u70ad\u6c34\u5316\u7269\u3084\u8102\u8cea\u306e\u4ee3\u8b1d\u52b9\u7387\u304c\u7570\u306a\u308a\u3001\u30c0\u30a4\u30a8\u30c3\u30c8\u65b9\u6cd5\u3082\u5909\u308f\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u3084\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u5206\u89e3\u80fd\u529b\u3001\u7761\u7720\u30ea\u30ba\u30e0\u306a\u3069\u3082\u907a\u4f1d\u7684\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u307e\u3059\u3002\u4eca\u5f8c\u3001AI\u3084\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u306e\u9032\u5316\u306b\u3088\u308a\u3001\u3088\u308a\u7cbe\u5bc6\u306a\u500b\u5225\u5316\u6804\u990a\u7ba1\u7406\u304c\u5b9f\u73fe\u3057\u3001\u5065\u5eb7\u7dad\u6301\u306e\u65b0\u305f\u306a\u9078\u629e\u80a2\u304c\u5e83\u304c\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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