{"id":405,"date":"2024-11-13T04:14:04","date_gmt":"2024-11-13T04:14:04","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=405"},"modified":"2025-04-08T03:35:00","modified_gmt":"2025-04-08T03:35:00","slug":"genetic-testing-drug-response","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/genetic-testing-drug-response\/","title":{"rendered":"\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u308f\u304b\u308b\u85ac\u5264\u306e\u52b9\u679c\u3068\u526f\u4f5c\u7528"},"content":{"rendered":"\n

\u85ac\u5264\u306e\u52b9\u679c\u3084\u526f\u4f5c\u7528\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u3001\u305d\u306e\u4e00\u56e0\u3068\u3057\u3066\u907a\u4f1d\u7684\u8981\u56e0\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u3005\u306e\u60a3\u8005\u306b\u9069\u3057\u305f\u85ac\u5264\u9078\u629e\u3084\u6295\u4e0e\u91cf\u306e\u8abf\u6574\u304c\u53ef\u80fd\u3068\u306a\u308a\u3001\u52b9\u679c\u7684\u304b\u3064\u5b89\u5168\u306a\u6cbb\u7642\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

1. \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u91cd\u8981\u6027<\/strong><\/h3>\n\n\n\n

\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308a\u3001\u85ac\u7269\u4ee3\u8b1d\u9175\u7d20\u3084\u85ac\u7269\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u306e\u907a\u4f1d\u5b50\u591a\u578b\u3092\u7279\u5b9a\u3057\u3001\u85ac\u5264\u306e\u52b9\u679c\u3084\u526f\u4f5c\u7528\u306e\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3067\u304d\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u5b9f\u73fe\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002 <\/p>\n\n\n\n

2. \u85ac\u7269\u4ee3\u8b1d\u9175\u7d20\u3068\u907a\u4f1d\u5b50\u591a\u578b<\/strong><\/h3>\n\n\n\n

\u85ac\u7269\u4ee3\u8b1d\u9175\u7d20\u306e\u907a\u4f1d\u5b50\u591a\u578b\u306f\u3001\u85ac\u5264\u306e\u4ee3\u8b1d\u901f\u5ea6\u3084\u52b9\u679c\u3001\u526f\u4f5c\u7528\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001CYP1A2\u907a\u4f1d\u5b50\u306e\u591a\u578b\u306b\u3088\u308a\u3001\u89e3\u71b1\u93ae\u75db\u85ac\u30d5\u30a7\u30ca\u30bb\u30c1\u30f3\u306e\u4ee3\u8b1d\u6d3b\u6027\u304c\u5909\u5316\u3057\u3001\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 <\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

3. \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u81e8\u5e8a\u5fdc\u7528<\/strong><\/h3>\n\n\n\n

\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u3001\u85ac\u5264\u306e\u52b9\u679c\u3084\u526f\u4f5c\u7528\u306e\u4e88\u6e2c\u306b\u6d3b\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u6297\u304c\u3093\u85ac\u306e\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u3092\u4e8b\u524d\u306b\u8a55\u4fa1\u3057\u3001\u9069\u5207\u306a\u6295\u4e0e\u91cf\u3092\u8a2d\u5b9a\u3059\u308b\u3053\u3068\u3067\u3001\u5b89\u5168\u306a\u6cbb\u7642\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002 <\/p>\n\n\n\n

4. \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u666e\u53ca\u3068\u8ab2\u984c<\/strong><\/h3>\n\n\n\n

\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u666e\u53ca\u306b\u3088\u308a\u3001\u85ac\u5264\u306e\u52b9\u679c\u3084\u526f\u4f5c\u7528\u306e\u500b\u4eba\u5dee\u3092\u8003\u616e\u3057\u305f\u6cbb\u7642\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u691c\u67fb\u7d50\u679c\u306e\u89e3\u91c8\u3084\u502b\u7406\u7684\u8ab2\u984c\u3082\u5b58\u5728\u3057\u3001\u614e\u91cd\u306a\u5bfe\u5fdc\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002 <\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u3001\u85ac\u5264\u306e\u52b9\u679c\u3084\u526f\u4f5c\u7528\u306e\u4e88\u6e2c\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u306e\u7814\u7a76\u3068\u6280\u8853\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u3088\u308a\u7cbe\u5ea6\u306e\u9ad8\u3044\u500b\u5225\u5316\u533b\u7642\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u691c\u67fb\u3068\u85ac\u5264\u4ee3\u8b1d\uff1a\u500b\u5225\u5316\u533b\u7642\u306e\u9032\u5c55<\/strong><\/h2>\n\n\n\n

\u85ac\u5264\u306e\u4f53\u5185\u3067\u306e\u6319\u52d5\u306f\u3001\u4e3b\u306b\u300c\u5438\u53ce\u300d\u300c\u5206\u5e03\u300d\u300c\u4ee3\u8b1d\u300d\u300c\u6392\u6cc4\uff08ADME\uff09\u300d\u306e\u904e\u7a0b\u3092\u7d4c\u3066\u6c7a\u307e\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u9175\u7d20\u3084\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u304c\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u6a5f\u80fd\u306f\u907a\u4f1d\u7684\u306a\u8981\u56e0\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u5de6\u53f3\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

1. CYP450\u9175\u7d20\u7fa4\u3068\u85ac\u7269\u4ee3\u8b1d<\/strong><\/h3>\n\n\n\n

\u809d\u81d3\u306b\u306f\u3001\u591a\u304f\u306e\u85ac\u5264\u306e\u4ee3\u8b1d\u3092\u62c5\u3046\u9175\u7d20\u7fa4\u3067\u3042\u308b**\u30b7\u30c8\u30af\u30ed\u30e0P450\uff08CYP450\uff09**\u304c\u3042\u308a\u307e\u3059\u3002\u7279\u306b\u3001CYP450\u306e\u907a\u4f1d\u5b50\u591a\u578b\u306f\u85ac\u5264\u306e\u4ee3\u8b1d\u901f\u5ea6\u3092\u6c7a\u5b9a\u3057\u3001\u6cbb\u7642\u306e\u6210\u5426\u306b\u5927\u304d\u304f\u5f71\u97ff\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

a. CYP2D6\u907a\u4f1d\u5b50\u3068\u6297\u3046\u3064\u85ac\u30fb\u93ae\u75db\u85ac<\/strong><\/h4>\n\n\n\n
\"\u771f\u4e0a\u304b\u3089\u898b\u305f\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3068\u30b9\u30d7\u30fc\u30f3\u3068\u6ce8\u5c04\"<\/figure>\n\n\n\n

CYP2D6\u306f\u3001\u6297\u3046\u3064\u85ac\uff08SSRI\u3084\u4e09\u74b0\u7cfb\u6297\u3046\u3064\u85ac\uff09\u3001\u03b2\u906e\u65ad\u85ac\u3001\u93ae\u75db\u85ac\uff08\u30b3\u30c7\u30a4\u30f3\u3084\u30c8\u30e9\u30de\u30c9\u30fc\u30eb\uff09\u306a\u3069\u3001\u591a\u304f\u306e\u85ac\u5264\u306e\u4ee3\u8b1d\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306b\u306f\u3044\u304f\u3064\u304b\u306e\u591a\u578b\u304c\u3042\u308a\u3001\u4ee3\u8b1d\u901f\u5ea6\u306b\u3088\u3063\u3066\u4ee5\u4e0b\u306e4\u3064\u306e\u30bf\u30a4\u30d7\u306b\u5206\u985e\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

    \n
  1. \u8d85\u9ad8\u901f\u4ee3\u8b1d\u578b\uff08UM\uff1aUltra-rapid metabolizer\uff09<\/strong> – \u85ac\u5264\u3092\u901a\u5e38\u3088\u308a\u901f\u304f\u4ee3\u8b1d\u3057\u3001\u52b9\u679c\u304c\u5341\u5206\u306b\u5f97\u3089\u308c\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n
  2. \u901a\u5e38\u4ee3\u8b1d\u578b\uff08EM\uff1aExtensive metabolizer\uff09<\/strong> – \u4e00\u822c\u7684\u306a\u4ee3\u8b1d\u80fd\u529b\u3092\u6301\u3064\u3002<\/li>\n\n\n\n
  3. \u4e2d\u9593\u4ee3\u8b1d\u578b\uff08IM\uff1aIntermediate metabolizer\uff09<\/strong> – \u4ee3\u8b1d\u80fd\u529b\u304c\u3084\u3084\u4f4e\u3044\u3002<\/li>\n\n\n\n
  4. \u4f4e\u4ee3\u8b1d\u578b\uff08PM\uff1aPoor metabolizer\uff09<\/strong> – \u4ee3\u8b1d\u304c\u6975\u3081\u3066\u9045\u304f\u3001\u85ac\u5264\u306e\u84c4\u7a4d\u306b\u3088\u308b\u526f\u4f5c\u7528\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3002<\/li>\n<\/ol>\n\n\n\n

    \u4f8b\u3048\u3070\u3001\u30b3\u30c7\u30a4\u30f3\u306fCYP2D6\u306b\u3088\u3063\u3066\u30e2\u30eb\u30d2\u30cd\u306b\u5909\u63db\u3055\u308c\u308b\u3053\u3068\u3067\u93ae\u75db\u52b9\u679c\u3092\u767a\u63ee\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u8d85\u9ad8\u901f\u4ee3\u8b1d\u578b<\/strong>\u306e\u4eba\u306f\u30e2\u30eb\u30d2\u30cd\u306e\u7523\u751f\u304c\u904e\u5270\u306b\u306a\u308a\u3001\u526f\u4f5c\u7528\uff08\u547c\u5438\u6291\u5236\u3084\u4e2d\u6bd2\uff09\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u305f\u3081\u3001\u6295\u4e0e\u91cf\u306e\u8abf\u6574\u304c\u5fc5\u8981\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

    (ncbi.nlm.nih.gov<\/a>)<\/p>\n\n\n\n

    \n <\/p>\n
    \n

    \u7c21\u5358\u30fb\u5b89\u5fc3\uff01
    \u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

    \u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

    <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

    b. CYP2C19\u3068\u6297\u8840\u5c0f\u677f\u85ac\u30fb\u6297\u3046\u3064\u85ac<\/strong><\/h4>\n\n\n\n

    CYP2C19\u306f\u3001**\u30af\u30ed\u30d4\u30c9\u30b0\u30ec\u30eb\uff08\u6297\u8840\u5c0f\u677f\u85ac\uff09\u3084<\/strong>\u30a8\u30b9\u30b7\u30bf\u30ed\u30d7\u30e9\u30e0\uff08\u6297\u3046\u3064\u85ac\uff09**\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002\u30af\u30ed\u30d4\u30c9\u30b0\u30ec\u30eb\u306f\u3001\u5fc3\u7b4b\u6897\u585e\u3084\u8133\u6897\u585e\u306e\u4e88\u9632\u306b\u7528\u3044\u3089\u308c\u308b\u85ac\u5264\u3067\u3059\u304c\u3001CYP2C19\u306e\u4ee3\u8b1d\u304c\u4f4e\u3044\u60a3\u8005\u3067\u306f\u85ac\u5264\u304c\u5341\u5206\u306b\u6d3b\u6027\u5316\u3055\u308c\u305a\u3001\u8840\u6813\u4e88\u9632\u52b9\u679c\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    \u305d\u306e\u305f\u3081\u3001**\u4f4e\u4ee3\u8b1d\u578b\uff08PM\uff09**\u306e\u60a3\u8005\u3067\u306f\u3001\u4ee3\u66ff\u85ac\uff08\u30d7\u30e9\u30b9\u30b0\u30ec\u30eb\u3084\u30c1\u30ab\u30b0\u30ec\u30ed\u30eb\u306a\u3069\uff09\u3078\u306e\u5207\u308a\u66ff\u3048\u304c\u63a8\u5968\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

    (fda.gov<\/a>)<\/p>\n\n\n\n

    \n <\/p>\n
    \n

    \u7c21\u5358\u30fb\u5b89\u5fc3\uff01
    \u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

    \u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

    <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

    2. \u85ac\u7269\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u3068\u85ac\u5264\u306e\u4f5c\u7528<\/strong><\/h3>\n\n\n\n

    \u85ac\u5264\u304c\u4f53\u5185\u3067\u3069\u306e\u3088\u3046\u306b\u5206\u5e03\u3057\u3001\u6a19\u7684\u306b\u5230\u9054\u3059\u308b\u304b\u306f\u3001\u85ac\u7269\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc<\/strong>\u3068\u547c\u3070\u308c\u308b\u5206\u5b50\u306e\u50cd\u304d\u306b\u3088\u3063\u3066\u6c7a\u307e\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

    a. ABCB1\u907a\u4f1d\u5b50\u3068P-\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\uff08P-gp\uff09<\/strong><\/h4>\n\n\n\n

    P-\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\uff08P-gp\uff09\u306f\u3001\u7d30\u80de\u819c\u4e0a\u306b\u5b58\u5728\u3057\u3001\u85ac\u5264\u3092\u7d30\u80de\u5916\u3078\u6392\u51fa\u3059\u308b\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u591a\u578b\u306b\u3088\u308a\u3001\u85ac\u5264\u306e\u4f53\u5185\u6fc3\u5ea6\u304c\u5927\u304d\u304f\u5909\u308f\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    \u4f8b\u3048\u3070\u3001P-gp\u306f\u3001\u6297\u304c\u3093\u5264\u3084HIV\u6cbb\u7642\u85ac\uff08\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u963b\u5bb3\u5264\uff09\u306a\u3069\u306e\u6392\u51fa\u3092\u4fc3\u9032\u3059\u308b\u305f\u3081\u3001\u6a5f\u80fd\u304c\u9ad8\u3044\u30bf\u30a4\u30d7<\/strong>\u306e\u907a\u4f1d\u5b50\u3092\u6301\u3064\u4eba\u306f\u85ac\u5264\u306e\u52b9\u679c\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u9006\u306b\u3001\u6a5f\u80fd\u304c\u4f4e\u3044\u30bf\u30a4\u30d7\u306e\u4eba\u3067\u306f\u85ac\u5264\u306e\u84c4\u7a4d\u304c\u8d77\u3053\u308a\u3001\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

    (sciencedirect.com<\/a>)<\/p>\n\n\n\n

    \n <\/p>\n
    \n

    \u7c21\u5358\u30fb\u5b89\u5fc3\uff01
    \u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

    \u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

    <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

    b. SLCO1B1\u907a\u4f1d\u5b50\u3068\u30b9\u30bf\u30c1\u30f3\u306e\u526f\u4f5c\u7528<\/strong><\/h4>\n\n\n\n
    \"\u52c9\u5f37\u4e2d\u306b\u982d\u75db\u304c\u3059\u308b\u30a2\u30b8\u30a2\u4eba\u5973\u602703\"<\/figure>\n\n\n\n

    \u30b9\u30bf\u30c1\u30f3\uff08\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u85ac\uff09\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u4e88\u9632\u306b\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u4e00\u90e8\u306e\u60a3\u8005\u3067\u306f\u7b4b\u969c\u5bb3\uff08\u6a2a\u7d0b\u7b4b\u878d\u89e3\u75c7\uff09\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30ea\u30b9\u30af\u306b\u95a2\u4e0e\u3059\u308b\u306e\u304c\u3001SLCO1B1\u907a\u4f1d\u5b50<\/strong>\u3067\u3059\u3002<\/p>\n\n\n\n

    SLCO1B1\u306f\u3001\u809d\u7d30\u80de\u3078\u306e\u85ac\u5264\u306e\u53d6\u308a\u8fbc\u307f\u3092\u62c5\u3046\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u3067\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u30b9\u30bf\u30c1\u30f3\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u4e0a\u6607\u3057\u3001\u526f\u4f5c\u7528\u304c\u51fa\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001SLCO1B1\u306e\u30ea\u30b9\u30af\u578b\u3092\u6301\u3064\u60a3\u8005\u306b\u306f\u3001\u4f4e\u7528\u91cf\u306e\u30b9\u30bf\u30c1\u30f3\u3084\u5225\u306e\u8102\u8cea\u7570\u5e38\u75c7\u6cbb\u7642\u85ac\uff08\u30a8\u30bc\u30c1\u30df\u30d6\u306a\u3069\uff09\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u304c\u63a8\u5968<\/strong>\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    (nejm.org<\/a>)<\/p>\n\n\n\n

    \n <\/p>\n
    \n

    \u7c21\u5358\u30fb\u5b89\u5fc3\uff01
    \u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

    \u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

    <\/a>\n<\/div>\n<\/div>\n\n\n\n

    3. \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u81e8\u5e8a\u5fdc\u7528\u3068\u4eca\u5f8c\u306e\u8ab2\u984c<\/strong><\/h3>\n\n\n\n

    a. \u533b\u7642\u73fe\u5834\u3067\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u5c0e\u5165<\/strong><\/h4>\n\n\n\n

    \u73fe\u5728\u3001\u591a\u304f\u306e\u533b\u7642\u6a5f\u95a2\u3067**\u30d5\u30a1\u30fc\u30de\u30b3\u30b2\u30ce\u30df\u30af\u30b9\uff08\u85ac\u7406\u907a\u4f1d\u5b66\uff09**\u304c\u5c0e\u5165\u3055\u308c\u3064\u3064\u3042\u308a\u3001\u7279\u5b9a\u306e\u75be\u60a3\u306b\u5bfe\u3059\u308b\u85ac\u5264\u9078\u629e\u306e\u7cbe\u5ea6\u5411\u4e0a\u304c\u56f3\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u304c\u3093\u6cbb\u7642\u3067\u306f\u3001\u907a\u4f1d\u5b50\u5909\u7570\u3092\u7279\u5b9a\u3059\u308b\u3053\u3068\u3067\u3001\u5206\u5b50\u6a19\u7684\u85ac\u306e\u9069\u5fdc\u3092\u5224\u65ad\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    \u4f8b\u3048\u3070\u3001EGFR\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u80ba\u304c\u3093\u60a3\u8005<\/strong>\u306b\u306f\u3001EGFR\u963b\u5bb3\u5264\uff08\u30b2\u30d5\u30a3\u30c1\u30cb\u30d6\u3001\u30a8\u30eb\u30ed\u30c1\u30cb\u30d6\uff09\u304c\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u304c\u3093\u6cbb\u7642\u306e\u500b\u5225\u5316\u306b\u304a\u3044\u3066\u4e0d\u53ef\u6b20\u306a\u30c4\u30fc\u30eb\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    \n <\/p>\n
    \n

    \u7c21\u5358\u30fb\u5b89\u5fc3\uff01
    \u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

    \u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

    <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

    b. \u30b3\u30b9\u30c8\u3068\u4fdd\u967a\u9069\u7528\u306e\u8ab2\u984c<\/strong><\/h4>\n\n\n\n

    \u4e00\u65b9\u3067\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u30b3\u30b9\u30c8\u3084\u4fdd\u967a\u9069\u7528\u306e\u554f\u984c\u304c\u666e\u53ca\u306e\u59a8\u3052\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u65e5\u672c\u3067\u306f\u4e00\u90e8\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u304c\u4fdd\u967a\u9069\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3059\u3079\u3066\u306e\u85ac\u5264\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u5b50\u691c\u67fb\u304c\u5b9f\u65bd\u3067\u304d\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n

    \u307e\u305f\u3001\u907a\u4f1d\u60c5\u5831\u306e\u53d6\u308a\u6271\u3044\u3084\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u4fdd\u8b77\u306e\u89b3\u70b9\u304b\u3089\u3001\u502b\u7406\u7684\u306a\u554f\u984c\u306b\u3082\u914d\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u7279\u306b\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u7d50\u679c\u304c\u751f\u547d\u4fdd\u967a\u3084\u96c7\u7528\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u306a\u3044\u3088\u3046\u3001\u9069\u5207\u306a\u6cd5\u6574\u5099\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    \u4eca\u5f8c\u3001\u6280\u8853\u306e\u9032\u6b69\u3068\u3068\u3082\u306b\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u30b3\u30b9\u30c8\u304c\u4f4e\u4e0b\u3057\u3001\u3088\u308a\u591a\u304f\u306e\u60a3\u8005\u306b\u500b\u5225\u5316\u533b\u7642\u304c\u63d0\u4f9b\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    \n <\/p>\n
    \n

    \u7c21\u5358\u30fb\u5b89\u5fc3\uff01
    \u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

    \u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

    <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

    \u907a\u4f1d\u5b50\u691c\u67fb\u3068\u85ac\u5264\u306e\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u7ba1\u7406<\/strong><\/h2>\n\n\n\n
    \"\u30aa\u30f3\u30e9\u30a4\u30f3\u8a3a\u7642\u306e\u524d\u306b\u8cc7\u6599\u3092\u8aad\u3080\u7537\u6027\u533b\u5e2b\"<\/figure>\n\n\n\n

    \u907a\u4f1d\u5b50\u691c\u67fb\u306f\u3001\u85ac\u5264\u306e\u526f\u4f5c\u7528\u3092\u4e8b\u524d\u306b\u4e88\u6e2c\u3057\u3001\u60a3\u8005\u3054\u3068\u306b\u9069\u5207\u306a\u51e6\u65b9\u3092\u884c\u3046\u305f\u3081\u306e\u91cd\u8981\u306a\u624b\u6bb5\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u85ac\u5264\u306e\u4ee3\u8b1d\u80fd\u529b\u3084\u514d\u75ab\u53cd\u5fdc\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306e\u591a\u578b\u3092\u7279\u5b9a\u3059\u308b\u3053\u3068\u3067\u3001\u526f\u4f5c\u7528\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

    1. \u907a\u4f1d\u5b50\u3068\u6297\u304c\u3093\u5264\u306e\u526f\u4f5c\u7528<\/strong><\/h3>\n\n\n\n

    \u6297\u304c\u3093\u5264\u306f\u3001\u9ad8\u3044\u52b9\u679c\u3092\u6301\u3064\u4e00\u65b9\u3067\u3001\u526f\u4f5c\u7528\u304c\u5f37\u304f\u51fa\u308b\u3053\u3068\u304c\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u526f\u4f5c\u7528\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3057\u3001\u3088\u308a\u5b89\u5168\u306a\u6cbb\u7642\u3092\u884c\u3046\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

    \n <\/p>\n
    \n

    \u7c21\u5358\u30fb\u5b89\u5fc3\uff01
    \u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

    \u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

    <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

    a. DPYD\u907a\u4f1d\u5b50\u3068\u30d5\u30eb\u30aa\u30ed\u30d4\u30ea\u30df\u30b8\u30f3\u7cfb\u6297\u304c\u3093\u5264\uff085-FU\u3001\u30ab\u30da\u30b7\u30bf\u30d3\u30f3\uff09<\/strong><\/h4>\n\n\n\n

    \u30d5\u30eb\u30aa\u30ed\u30d4\u30ea\u30df\u30b8\u30f3\u7cfb\u6297\u304c\u3093\u5264\uff085-FU\u3084\u30ab\u30da\u30b7\u30bf\u30d3\u30f3\uff09\u306f\u3001\u5927\u8178\u304c\u3093\u3084\u4e73\u304c\u3093\u306e\u6cbb\u7642\u306b\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u4e00\u90e8\u306e\u60a3\u8005\u3067\u306f\u3001\u3053\u306e\u85ac\u5264\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308bDPYD\u907a\u4f1d\u5b50<\/strong>\u306e\u5909\u7570\u306b\u3088\u308a\u3001\u91cd\u7be4\u306a\u526f\u4f5c\u7528\uff08\u9aa8\u9ac4\u6291\u5236\u3001\u6d88\u5316\u7ba1\u969c\u5bb3\u3001\u795e\u7d4c\u969c\u5bb3\u306a\u3069\uff09\u304c\u767a\u751f\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

    DPYD\u907a\u4f1d\u5b50\u306e\u5909\u7570\u578b\u3092\u6301\u3064\u60a3\u8005\u3067\u306f\u3001\u85ac\u5264\u306e\u5206\u89e3\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u3001\u4f53\u5185\u306b\u84c4\u7a4d\u3057\u3066\u3057\u307e\u3046\u305f\u3081\u3001\u901a\u5e38\u3088\u308a\u3082\u4f4e\u7528\u91cf\u306e\u6295\u4e0e\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002\u7279\u306b\u3001DPYD*2A<\/strong>\u5909\u7570\u3092\u6301\u3064\u60a3\u8005\u3067\u306f\u30015-FU\u306e\u6295\u4e0e\u3092\u907f\u3051\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    (oncologypractice.com<\/a>)<\/p>\n\n\n\n

    \n <\/p>\n
    \n

    \u7c21\u5358\u30fb\u5b89\u5fc3\uff01
    \u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

    \u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

    <\/a>\n<\/div>\n<\/div>\n\n\n\n

    b. UGT1A1\u907a\u4f1d\u5b50\u3068\u30a4\u30ea\u30ce\u30c6\u30ab\u30f3\u306e\u526f\u4f5c\u7528<\/strong><\/h4>\n\n\n\n

    \u30a4\u30ea\u30ce\u30c6\u30ab\u30f3\u306f\u3001\u5927\u8178\u304c\u3093\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u56fa\u5f62\u304c\u3093\u306e\u6cbb\u7642\u306b\u7528\u3044\u3089\u308c\u308b\u6297\u304c\u3093\u5264\u3067\u3059\u3002\u3053\u306e\u85ac\u5264\u306f\u3001UGT1A1\u907a\u4f1d\u5b50<\/strong>\u304c\u30b3\u30fc\u30c9\u3059\u308b\u9175\u7d20\u306b\u3088\u3063\u3066\u4ee3\u8b1d\u3055\u308c\u307e\u3059\u304c\u3001UGT1A128\u3084UGT1A1<\/em>6\u306e\u591a\u578b\u3092\u6301\u3064\u60a3\u8005\u3067\u306f\u3001\u4ee3\u8b1d\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u3001\u9aa8\u9ac4\u6291\u5236\u3084\u91cd\u7be4\u306a\u4e0b\u75e2\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    \u3053\u306e\u305f\u3081\u3001UGT1A1\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u884c\u3044\u3001\u30ea\u30b9\u30af\u578b\u3092\u6301\u3064\u60a3\u8005\u306b\u306f\u6e1b\u91cf\u3092\u884c\u3046\u304b\u3001\u5225\u306e\u6cbb\u7642\u6cd5\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    (ascopubs.org<\/a>)<\/p>\n\n\n\n

    \n <\/p>\n
    \n

    \u7c21\u5358\u30fb\u5b89\u5fc3\uff01
    \u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

    \u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

    <\/a>\n<\/div>\n<\/div>\n\n\n\n

    2. \u907a\u4f1d\u5b50\u3068\u514d\u75ab\u95a2\u9023\u526f\u4f5c\u7528<\/strong><\/h3>\n\n\n\n

    \u8fd1\u5e74\u3001\u304c\u3093\u514d\u75ab\u7642\u6cd5\u304c\u767a\u5c55\u3057\u3001**\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\uff08ICI\uff09**\u304c\u5e83\u304f\u7528\u3044\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u3089\u306e\u85ac\u5264\u306f\u3001\u514d\u75ab\u7cfb\u3092\u6d3b\u6027\u5316\u3059\u308b\u305f\u3081\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306b\u4f3c\u305f\u526f\u4f5c\u7528\uff08\u514d\u75ab\u95a2\u9023\u6709\u5bb3\u4e8b\u8c61\uff1airAE\uff09\u304c\u767a\u751f\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

    \n <\/p>\n
    \n

    \u7c21\u5358\u30fb\u5b89\u5fc3\uff01
    \u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

    \u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

    <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

    a. HLA\u907a\u4f1d\u5b50\u3068\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306e\u526f\u4f5c\u7528<\/strong><\/h4>\n\n\n\n
    \"\u30ac\u30e9\u30b9\u5bb9\u5668\u3092\u6301\u3063\u3066\u3044\u308b\u4eba\u306e\u624b\u5143\"<\/figure>\n\n\n\n

    HLA\uff08\u30d2\u30c8\u767d\u8840\u7403\u6297\u539f\uff09\u907a\u4f1d\u5b50\u306f\u3001\u514d\u75ab\u7cfb\u306e\u6a5f\u80fd\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u7279\u5b9a\u306eHLA\u578b\u3092\u6301\u3064\u4eba\u306fICI\u306e\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001HLA-DRB1*04:05<\/strong>\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u60a3\u8005\u306f\u3001ICI\u306b\u3088\u308b\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u69d8\u306e\u526f\u4f5c\u7528\u304c\u767a\u751f\u3057\u3084\u3059\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    \u305d\u306e\u305f\u3081\u3001\u4e8b\u524d\u306bHLA\u907a\u4f1d\u5b50\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u3092\u7279\u5b9a\u3057\u3001\u614e\u91cd\u306a\u6295\u4e0e\u8a08\u753b\u3092\u7acb\u3066\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

    (nature.com<\/a>)<\/p>\n\n\n\n

    \n <\/p>\n
    \n

    \u7c21\u5358\u30fb\u5b89\u5fc3\uff01
    \u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

    \u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

    <\/a>\n<\/div>\n<\/div>\n\n\n\n

    3. \u907a\u4f1d\u5b50\u3068\u9ebb\u9154\u85ac\u306e\u5b89\u5168\u6027<\/strong><\/h3>\n\n\n\n

    \u624b\u8853\u6642\u306b\u4f7f\u7528\u3055\u308c\u308b\u9ebb\u9154\u85ac\u306e\u52b9\u679c\u3084\u526f\u4f5c\u7528\u3082\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u5f71\u97ff\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u5438\u5165\u9ebb\u9154\u85ac\u3084\u7b4b\u5f1b\u7de9\u85ac\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u7684\u611f\u53d7\u6027\u306f\u3001\u60a3\u8005\u306e\u5b89\u5168\u6027\u306b\u76f4\u7d50\u3059\u308b\u305f\u3081\u3001\u4e8b\u524d\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u304c\u6709\u52b9\u3067\u3059\u3002<\/p>\n\n\n\n

    a. RYR1\u907a\u4f1d\u5b50\u3068\u60aa\u6027\u9ad8\u71b1\u75c7<\/strong><\/h4>\n\n\n\n

    **\u60aa\u6027\u9ad8\u71b1\u75c7\uff08MH\uff09**\u306f\u3001\u63ee\u767a\u6027\u9ebb\u9154\u85ac\uff08\u30bb\u30dc\u30d5\u30eb\u30e9\u30f3\u3001\u30a4\u30bd\u30d5\u30eb\u30e9\u30f3\u306a\u3069\uff09\u3084\u7b4b\u5f1b\u7de9\u85ac\uff08\u30b9\u30ad\u30b5\u30e1\u30c8\u30cb\u30a6\u30e0\uff09\u306b\u53cd\u5fdc\u3057\u3066\u767a\u751f\u3059\u308b\u91cd\u7be4\u306a\u526f\u4f5c\u7528\u3067\u3059\u3002RYR1\u907a\u4f1d\u5b50<\/strong>\u306b\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u5236\u5fa1\u304c\u7570\u5e38\u306b\u306a\u308a\u3001\u7b4b\u786c\u76f4\u3001\u9ad8\u4f53\u6e29\u3001\u4ee3\u8b1d\u6027\u30a2\u30b7\u30c9\u30fc\u30b7\u30b9\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

    MH\u306e\u30ea\u30b9\u30af\u3092\u6301\u3064\u60a3\u8005\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u85ac\u5264\u3092\u907f\u3051\u308b\u304b\u3001\u4ee3\u66ff\u9ebb\u9154\u85ac\uff08\u30d7\u30ed\u30dd\u30d5\u30a9\u30fc\u30eb\u306a\u3069\uff09\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u5b89\u5168\u306b\u624b\u8853\u3092\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

    (mhgenetics.org<\/a>)<\/p>\n\n\n\n

    \n <\/p>\n
    \n

    \u7c21\u5358\u30fb\u5b89\u5fc3\uff01
    \u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

    \u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

    <\/a>\n<\/div>\n<\/div>\n\n\n\n

    b. BCHE\u907a\u4f1d\u5b50\u3068\u30b9\u30ad\u30b5\u30e1\u30c8\u30cb\u30a6\u30e0\u611f\u53d7\u6027<\/strong><\/h4>\n\n\n\n

    \u7b4b\u5f1b\u7de9\u85ac\u30b9\u30ad\u30b5\u30e1\u30c8\u30cb\u30a6\u30e0\u306f\u3001\u77ed\u6642\u9593\u306e\u7b4b\u5f1b\u7de9\u3092\u76ee\u7684\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u304c\u3001\u4e00\u90e8\u306e\u60a3\u8005\u3067\u306f\u7570\u5e38\u306b\u9577\u3044\u9ebb\u75fa\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u3001**\u30d6\u30c1\u30ea\u30eb\u30b3\u30ea\u30f3\u30a8\u30b9\u30c6\u30e9\u30fc\u30bc\uff08BCHE\uff09**\u907a\u4f1d\u5b50\u306e\u591a\u578b\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u305f\u3081\u3067\u3059\u3002<\/p>\n\n\n\n

    BCHE\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u308a\u3001\u30b9\u30ad\u30b5\u30e1\u30c8\u30cb\u30a6\u30e0\u306e\u5206\u89e3\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u3001\u60a3\u8005\u304c\u9ebb\u9154\u304b\u3089\u899a\u3081\u306b\u304f\u304f\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u4e8b\u524d\u306bBCHE\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u9069\u5207\u306a\u9ebb\u9154\u85ac\u3092\u9078\u629e\u3057\u3001\u5b89\u5168\u306a\u624b\u8853\u3092\u5b9f\u73fe\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

    (anesthesia-patient-safety.org<\/a>)<\/p>\n\n\n\n

    \n <\/p>\n
    \n

    \u7c21\u5358\u30fb\u5b89\u5fc3\uff01
    \u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

    \u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

    <\/a>\n<\/div>\n<\/div>\n\n\n\n

    4. \u907a\u4f1d\u5b50\u691c\u67fb\u3068\u7cbe\u795e\u79d1\u9818\u57df\u3067\u306e\u5fdc\u7528<\/strong><\/h3>\n\n\n\n
    \"\u982d\u3092\u62bc\u3055\u3048\u308b\u5973\u6027\"<\/figure>\n\n\n\n

    \u7cbe\u795e\u79d1\u9818\u57df\u3067\u306f\u3001\u6297\u7cbe\u795e\u75c5\u85ac\u3084\u6297\u3046\u3064\u85ac\u306e\u52b9\u679c\u304c\u500b\u4eba\u5dee\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u7570\u306a\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u60a3\u8005\u306b\u6700\u9069\u306a\u85ac\u5264\u3092\u9078\u629e\u3057\u3001\u526f\u4f5c\u7528\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

    \u4f8b\u3048\u3070\u3001HTR2A\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u6297\u7cbe\u795e\u75c5\u85ac\u306e\u52b9\u679c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u7279\u5b9a\u306e\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u85ac\u5264\u306e\u526f\u4f5c\u7528\uff08\u4f53\u91cd\u5897\u52a0\u3001\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u306a\u3069\uff09\u304c\u9ad8\u304f\u306a\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    \u307e\u305f\u3001COMT\u907a\u4f1d\u5b50<\/strong>\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u306b\u3088\u3063\u3066\u3001\u30c9\u30fc\u30d1\u30df\u30f3\u306e\u5206\u89e3\u901f\u5ea6\u304c\u5909\u5316\u3057\u3001\u7d71\u5408\u5931\u8abf\u75c7\u306e\u6cbb\u7642\u85ac\u306e\u52b9\u679c\u304c\u5de6\u53f3\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u8003\u616e\u3057\u305f\u51e6\u65b9\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

    (psychgenetics.org<\/a>)<\/p>\n\n\n\n

    \n <\/p>\n
    \n

    \u7c21\u5358\u30fb\u5b89\u5fc3\uff01
    \u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

    \u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

    <\/a>\n<\/div>\n<\/div>\n\n\n\n

    \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u767a\u5c55\u306b\u3088\u308a\u3001\u85ac\u5264\u306e\u5b89\u5168\u6027\u3092\u5411\u4e0a\u3055\u305b\u3001\u3088\u308a\u7cbe\u5bc6\u306a\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3001\u3055\u3089\u306b\u591a\u304f\u306e\u85ac\u5264\u3067\u907a\u4f1d\u5b50\u691c\u67fb\u304c\u6a19\u6e96\u5316\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    \u907a\u4f1d\u5b50\u691c\u67fb\u3068\u6297\u751f\u7269\u8cea\u306e\u52b9\u679c\u30fb\u526f\u4f5c\u7528<\/strong><\/h2>\n\n\n\n

    \u6297\u751f\u7269\u8cea\u306f\u7d30\u83cc\u611f\u67d3\u75c7\u306e\u6cbb\u7642\u306b\u4e0d\u53ef\u6b20\u3067\u3059\u304c\u3001\u85ac\u5264\u306e\u52b9\u679c\u3084\u526f\u4f5c\u7528\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u3001\u305d\u306e\u8981\u56e0\u3068\u3057\u3066\u907a\u4f1d\u7684\u80cc\u666f\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u5b89\u5168\u304b\u3064\u52b9\u679c\u7684\u306a\u6297\u751f\u7269\u8cea\u306e\u4f7f\u7528\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

    \n <\/p>\n
    \n

    \u7c21\u5358\u30fb\u5b89\u5fc3\uff01
    \u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

    \u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

    <\/a>\n<\/div>\n<\/div>\n\n\n\n

    1. \u30a2\u30df\u30ce\u30b0\u30ea\u30b3\u30b7\u30c9\u7cfb\u6297\u751f\u7269\u8cea\u3068\u907a\u4f1d\u5b50\u591a\u578b<\/strong><\/h3>\n\n\n\n

    \u30a2\u30df\u30ce\u30b0\u30ea\u30b3\u30b7\u30c9\u7cfb\u6297\u751f\u7269\u8cea\uff08\u30b9\u30c8\u30ec\u30d7\u30c8\u30de\u30a4\u30b7\u30f3\u3001\u30b2\u30f3\u30bf\u30de\u30a4\u30b7\u30f3\u3001\u30a2\u30df\u30ab\u30b7\u30f3\u306a\u3069\uff09\u306f\u3001\u7d30\u83cc\u306e\u30ea\u30dc\u30bd\u30fc\u30e0\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u6bba\u83cc\u52b9\u679c\u3092\u767a\u63ee\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u3089\u306e\u85ac\u5264\u306b\u306f\u96e3\u8074<\/strong>\u3068\u3044\u3046\u91cd\u5927\u306a\u526f\u4f5c\u7528\u304c\u3042\u308a\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    \n <\/p>\n
    \n

    \u7c21\u5358\u30fb\u5b89\u5fc3\uff01
    \u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

    \u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

    <\/a>\n<\/div>\n<\/div>\n\n\n\n

    a. MT-RNR1\u907a\u4f1d\u5b50\u3068\u30a2\u30df\u30ce\u30b0\u30ea\u30b3\u30b7\u30c9\u8a98\u767a\u6027\u96e3\u8074<\/strong><\/h4>\n\n\n\n

    \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u306b\u3042\u308bMT-RNR1\u907a\u4f1d\u5b50<\/strong>\u306e\u5909\u7570\uff08\u7279\u306bm.1555A>G\u5909\u7570\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u30a2\u30df\u30ce\u30b0\u30ea\u30b3\u30b7\u30c9\u7cfb\u6297\u751f\u7269\u8cea\u306b\u5bfe\u3057\u3066\u904e\u654f\u3067\u3042\u308a\u3001\u901a\u5e38\u306e\u6295\u4e0e\u91cf\u3067\u3082\u6025\u6fc0\u306a\u611f\u97f3\u6027\u96e3\u8074\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    \u3053\u306e\u305f\u3081\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3067MT-RNR1\u306e\u5909\u7570\u304c\u78ba\u8a8d\u3055\u308c\u305f\u5834\u5408\u3001\u30a2\u30df\u30ce\u30b0\u30ea\u30b3\u30b7\u30c9\u306e\u4f7f\u7528\u3092\u907f\u3051\u3001\u5225\u306e\u6297\u751f\u7269\u8cea\uff08\u30bb\u30d5\u30a1\u30ed\u30b9\u30dd\u30ea\u30f3\u3084\u30d5\u30eb\u30aa\u30ed\u30ad\u30ce\u30ed\u30f3\u7cfb\uff09\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    (nature.com<\/a>)<\/p>\n\n\n\n

    \n <\/p>\n
    \n

    \u7c21\u5358\u30fb\u5b89\u5fc3\uff01
    \u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

    \u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

    <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

    2. \u30d5\u30eb\u30aa\u30ed\u30ad\u30ce\u30ed\u30f3\u7cfb\u6297\u751f\u7269\u8cea\u3068\u8171\u65ad\u88c2\u30ea\u30b9\u30af<\/strong><\/h3>\n\n\n\n
    \"\n\u3075\u304f\u3089\u306f\u304e\u304c\u75db\u3044\u5973\u6027\"<\/figure>\n\n\n\n

    \u30d5\u30eb\u30aa\u30ed\u30ad\u30ce\u30ed\u30f3\u7cfb\u6297\u751f\u7269\u8cea\uff08\u30ec\u30dc\u30d5\u30ed\u30ad\u30b5\u30b7\u30f3\u3001\u30b7\u30d7\u30ed\u30d5\u30ed\u30ad\u30b5\u30b7\u30f3\u306a\u3069\uff09\u306f\u3001\u5e83\u7bc4\u56f2\u306e\u7d30\u83cc\u306b\u5bfe\u3057\u3066\u6709\u52b9\u306a\u85ac\u5264\u3067\u3059\u304c\u3001\u526f\u4f5c\u7528\u3068\u3057\u3066\u8171\u65ad\u88c2\u306e\u30ea\u30b9\u30af\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    a. MMP3\u907a\u4f1d\u5b50\u3068\u8171\u969c\u5bb3\u30ea\u30b9\u30af<\/strong><\/h4>\n\n\n\n

    MMP3\uff08\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc3\uff09\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u8171\u3084\u976d\u5e2f\u306e\u7d50\u5408\u7d44\u7e54\u306e\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u30d5\u30eb\u30aa\u30ed\u30ad\u30ce\u30ed\u30f3\u7cfb\u6297\u751f\u7269\u8cea\u3092\u4f7f\u7528\u3057\u305f\u969b\u306b\u8171\u708e\u3084\u8171\u65ad\u88c2\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    \u7279\u306b\u3001\u9ad8\u9f62\u8005\u3084\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u4f75\u7528\u3057\u3066\u3044\u308b\u60a3\u8005\u3067\u306f\u3001\u3053\u306e\u30ea\u30b9\u30af\u304c\u3055\u3089\u306b\u5897\u52a0\u3059\u308b\u305f\u3081\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308b\u4e8b\u524d\u8a55\u4fa1\u304c\u6709\u52b9\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    (bmj.com<\/a>)<\/p>\n\n\n\n

    \n <\/p>\n
    \n

    \u7c21\u5358\u30fb\u5b89\u5fc3\uff01
    \u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

    \u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

    <\/a>\n<\/div>\n<\/div>\n\n\n\n

    3. \u03b2-\u30e9\u30af\u30bf\u30e0\u7cfb\u6297\u751f\u7269\u8cea\u3068\u30a2\u30ec\u30eb\u30ae\u30fc<\/strong><\/h3>\n\n\n\n

    \u03b2-\u30e9\u30af\u30bf\u30e0\u7cfb\u6297\u751f\u7269\u8cea\uff08\u30da\u30cb\u30b7\u30ea\u30f3\u3001\u30bb\u30d5\u30a1\u30ed\u30b9\u30dd\u30ea\u30f3\u306a\u3069\uff09\u306f\u3001\u7d30\u80de\u58c1\u5408\u6210\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u6bba\u83cc\u52b9\u679c\u3092\u767a\u63ee\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u4e00\u90e8\u306e\u60a3\u8005\u3067\u306f\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\uff08\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\uff09\u304c\u767a\u751f\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

    a. HLA\u907a\u4f1d\u5b50\u3068\u30da\u30cb\u30b7\u30ea\u30f3\u30a2\u30ec\u30eb\u30ae\u30fc<\/strong><\/h4>\n\n\n\n

    HLA\uff08\u30d2\u30c8\u767d\u8840\u7403\u6297\u539f\uff09\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u306f\u3001\u85ac\u5264\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001HLA-B*55:01<\/strong>\u3092\u6301\u3064\u60a3\u8005\u306f\u30da\u30cb\u30b7\u30ea\u30f3\u7cfb\u6297\u751f\u7269\u8cea\u306b\u5bfe\u3059\u308b\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    \u3053\u306e\u3088\u3046\u306a\u60a3\u8005\u306b\u5bfe\u3057\u3066\u306f\u3001\u4e8b\u524d\u306b\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u4ee3\u66ff\u85ac\u3092\u9078\u629e\u3057\u3001\u5b89\u5168\u306a\u6cbb\u7642\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

    (nejm.org<\/a>)<\/p>\n\n\n\n

    \n <\/p>\n
    \n

    \u7c21\u5358\u30fb\u5b89\u5fc3\uff01
    \u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

    \u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

    <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

    \u907a\u4f1d\u5b50\u691c\u67fb\u3068\u93ae\u75db\u85ac\u306e\u52b9\u679c\u30fb\u526f\u4f5c\u7528<\/strong><\/h2>\n\n\n\n

    \u93ae\u75db\u85ac\u306e\u52b9\u679c\u3084\u526f\u4f5c\u7528\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u3001\u7279\u306b\u30aa\u30d4\u30aa\u30a4\u30c9\u7cfb\u93ae\u75db\u85ac\u3067\u306f\u3001\u907a\u4f1d\u5b50\u591a\u578b\u304c\u85ac\u5264\u306e\u4ee3\u8b1d\u3084\u4f9d\u5b58\u6027\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    1. \u30aa\u30d4\u30aa\u30a4\u30c9\u7cfb\u93ae\u75db\u85ac\u3068CYP2D6\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n

    CYP2D6\u907a\u4f1d\u5b50<\/strong>\u306e\u591a\u578b\u306f\u3001\u30b3\u30c7\u30a4\u30f3\u3084\u30c8\u30e9\u30de\u30c9\u30fc\u30eb\u306a\u3069\u306e\u30aa\u30d4\u30aa\u30a4\u30c9\u7cfb\u93ae\u75db\u85ac\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n