{"id":420,"date":"2024-11-13T04:49:55","date_gmt":"2024-11-13T04:49:55","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=420"},"modified":"2025-04-09T01:28:45","modified_gmt":"2025-04-09T01:28:45","slug":"skincare-aging-genetics-hcl","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/skincare-aging-genetics-hcl\/","title":{"rendered":"\u907a\u4f1d\u5b50\u60c5\u5831\u3068\u808c\u306e\u8001\u5316\uff1a\u7f8e\u5bb9\u3078\u306e\u5fdc\u7528"},"content":{"rendered":"\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u5e8f\u8ad6\uff1a\u907a\u4f1d\u5b50\u3068\u808c\u306e\u8001\u5316\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u808c\u306e\u8001\u5316\u306f\u3001\u52a0\u9f62\u306b\u4f34\u3046\u81ea\u7136\u306a\u30d7\u30ed\u30bb\u30b9\u3067\u3059\u304c\u3001\u305d\u306e\u30b9\u30d4\u30fc\u30c9\u3084\u75c7\u72b6\u306e\u73fe\u308c\u65b9\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u9055\u3044\u306b\u306f\u3001\u7d2b\u5916\u7dda\u3084\u751f\u6d3b\u7fd2\u6163\u306a\u3069\u306e\u74b0\u5883\u8981\u56e0\u3060\u3051\u3067\u306a\u304f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3082\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u808c\u306e\u8001\u5316\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u7f8e\u5bb9\uff08\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30fb\u30b9\u30ad\u30f3\u30b1\u30a2\uff09\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u672c\u8a18\u4e8b\u3067\u306f\u3001\u808c\u306e\u8001\u5316\u306b\u95a2\u4e0e\u3059\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308b\u7f8e\u5bb9\u30a2\u30d7\u30ed\u30fc\u30c1\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u5bfe\u7b56\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>1. \u808c\u306e\u8001\u5316\u306b\u95a2\u308f\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50<\/strong><\/h2>\n\n\n\n<p>\u808c\u306e\u8001\u5316\u306f\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u3084\u30a8\u30e9\u30b9\u30c1\u30f3\u306e\u6e1b\u5c11\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3001DNA\u640d\u50b7\u306a\u3069\u306e\u751f\u7269\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u306b\u3088\u3063\u3066\u9032\u884c\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u95a2\u4e0e\u3059\u308b\u4e3b\u306a\u907a\u4f1d\u5b50\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1.1 MMP1\u907a\u4f1d\u5b50\uff1a\u30b3\u30e9\u30fc\u30b2\u30f3\u5206\u89e3<\/strong><\/h3>\n\n\n\n<p>MMP1\uff08\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a4\u30ca\u30fc\u30bc1\uff09\u907a\u4f1d\u5b50\u306f\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u591a\u578b\u3092\u6301\u3064\u4eba\u306fMMP1\u306e\u6d3b\u6027\u304c\u9ad8\u304f\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u304c\u65e9\u304f\u5206\u89e3\u3055\u308c\u308b\u305f\u3081\u3001\u30b7\u30ef\u304c\u3067\u304d\u3084\u3059\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5bfe\u7b56<\/strong>\uff1a\u30ec\u30c1\u30ce\u30fc\u30eb\u3084\u30d3\u30bf\u30df\u30f3C\u3092\u542b\u3080\u30b9\u30ad\u30f3\u30b1\u30a2\u3092\u4f7f\u7528\u3057\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u5206\u89e3\u3092\u6291\u5236\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1.2 COL1A1\u907a\u4f1d\u5b50\uff1a\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u751f\u6210\u80fd\u529b<\/strong><\/h3>\n\n\n\n<p>COL1A1\u907a\u4f1d\u5b50\u306f\u3001\u808c\u306e\u5f3e\u529b\u3092\u7dad\u6301\u3059\u308b\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u751f\u6210\u3092\u8abf\u7bc0\u3057\u307e\u3059\u3002\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u5408\u6210\u304c\u4f4e\u4e0b\u3057\u3001\u305f\u308b\u307f\u3084\u30b7\u30ef\u304c\u767a\u751f\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5bfe\u7b56<\/strong>\uff1a\u30b3\u30e9\u30fc\u30b2\u30f3\u30da\u30d7\u30c1\u30c9\u306e\u6442\u53d6\u3001\u7d2b\u5916\u7dda\u5bfe\u7b56\u3001\u9069\u5207\u306a\u4fdd\u6e7f\u30b1\u30a2\u3092\u5b9f\u65bd\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1.3 SOD2\u907a\u4f1d\u5b50\uff1a\u6297\u9178\u5316\u9632\u5fa1<\/strong><\/h3>\n\n\n\n<p>SOD2\u907a\u4f1d\u5b50\u306f\u3001\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u30b8\u30b9\u30e0\u30bf\u30fc\u30bc\uff08SOD\uff09\u3068\u3044\u3046\u6297\u9178\u5316\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3057\u3001\u6d3b\u6027\u9178\u7d20\u3092\u5206\u89e3\u3059\u308b\u5f79\u5272\u3092\u62c5\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u84c4\u7a4d\u3057\u3001\u808c\u8001\u5316\u304c\u52a0\u901f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5bfe\u7b56<\/strong>\uff1a\u6297\u9178\u5316\u98df\u54c1\uff08\u30d3\u30bf\u30df\u30f3E\u3001\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3057\u3001\u7d2b\u5916\u7dda\u3084\u5927\u6c17\u6c5a\u67d3\u306e\u5f71\u97ff\u3092\u8efd\u6e1b\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1.4 MC1R\u907a\u4f1d\u5b50\uff1a\u7d2b\u5916\u7dda\u8010\u6027\u3068\u30b7\u30df\u306e\u30ea\u30b9\u30af<\/strong><\/h3>\n\n\n\n<p>MC1R\u907a\u4f1d\u5b50\u306f\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3092\u5236\u5fa1\u3057\u3001\u7d2b\u5916\u7dda\u306b\u3088\u308bDNA\u640d\u50b7\u304b\u3089\u808c\u3092\u5b88\u308b\u50cd\u304d\u3092\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u7d2b\u5916\u7dda\u306b\u5bfe\u3059\u308b\u8010\u6027\u304c\u4f4e\u304f\u306a\u308a\u3001\u30b7\u30df\u3084\u8272\u7d20\u6c88\u7740\u304c\u3067\u304d\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5bfe\u7b56<\/strong>\uff1a\u65e5\u713c\u3051\u6b62\u3081\u306e\u4f7f\u7528\u3092\u5fb9\u5e95\u3057\u3001\u7f8e\u767d\u6210\u5206\uff08\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u3001\u30a2\u30eb\u30d6\u30c1\u30f3\uff09\u3092\u6d3b\u7528\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1.5 FOXO3\u907a\u4f1d\u5b50\uff1a\u7d30\u80de\u306e\u8001\u5316\u6291\u5236<\/strong><\/h3>\n\n\n\n<p>FOXO3\u907a\u4f1d\u5b50\u306f\u3001\u7d30\u80de\u306e\u4fee\u5fa9\u3084\u5bff\u547d\u306b\u95a2\u308f\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u5909\u7570\u304c\u3042\u308b\u3068\u3001DNA\u4fee\u5fa9\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u3001\u808c\u306e\u8001\u5316\u304c\u65e9\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5bfe\u7b56<\/strong>\uff1aNMN\u3084\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u306a\u3069\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u6210\u5206\u3092\u6442\u53d6\u3057\u3001DNA\u4fee\u5fa9\u3092\u4fc3\u9032\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. \u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308b\u500b\u5225\u5316\u7f8e\u5bb9\u306e\u53ef\u80fd\u6027<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/02\/31733518_m-1024x683.jpg\" alt=\"\u82e5\u3044\u65e5\u672c\u4eba\u5973\u6027\u306e\u7f8e\u5bb9\u30a4\u30e1\u30fc\u30b8\" class=\"wp-image-7780\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31733518_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31733518_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31733518_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31733518_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31733518_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2.1 \u907a\u4f1d\u5b50\u691c\u67fb\u3067\u308f\u304b\u308b\u3053\u3068<\/strong><\/h3>\n\n\n\n<p>\u7f8e\u5bb9\u5411\u3051\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u9805\u76ee\u3092\u5206\u6790\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30b7\u30ef\u306e\u30ea\u30b9\u30af\uff08MMP1\u3001COL1A1\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u30b7\u30df\u30fb\u8272\u7d20\u6c88\u7740\u306e\u30ea\u30b9\u30af\uff08MC1R\u3001TYR\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u6297\u9178\u5316\u80fd\u529b\uff08SOD2\u3001GPX1\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u7d2b\u5916\u7dda\u8010\u6027\uff08MC1R\u3001ASIP\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u4fdd\u6e7f\u6a5f\u80fd\uff08FLG\u907a\u4f1d\u5b50\uff09<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2.2 \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u6d3b\u7528\u65b9\u6cd5<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u7d50\u679c\u306b\u57fa\u3065\u3044\u3066\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u500b\u5225\u5316\u30b9\u30ad\u30f3\u30b1\u30a2\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6297\u9178\u5316\u80fd\u529b\u304c\u4f4e\u3044\u4eba<\/strong> \u2192 \u30d3\u30bf\u30df\u30f3C\u3084\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3092\u542b\u3080\u30b9\u30ad\u30f3\u30b1\u30a2\u3092\u5f37\u5316<\/li>\n\n\n\n<li><strong>\u7d2b\u5916\u7dda\u306b\u5f31\u3044\u4eba<\/strong> \u2192 \u9ad8SPF\u306e\u65e5\u713c\u3051\u6b62\u3081\u3092\u3053\u307e\u3081\u306b\u5857\u308b<\/li>\n\n\n\n<li><strong>\u30b3\u30e9\u30fc\u30b2\u30f3\u5206\u89e3\u304c\u9032\u307f\u3084\u3059\u3044\u4eba<\/strong> \u2192 \u30ec\u30c1\u30ce\u30fc\u30eb\u3084\u30da\u30d7\u30c1\u30c9\u6210\u5206\u3092\u53d6\u308a\u5165\u308c\u308b<\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u3001\u4e00\u4eba\u3072\u3068\u308a\u306e\u808c\u8cea\u306b\u5408\u3063\u305f\u6700\u9069\u306a\u7f8e\u5bb9\u5bfe\u7b56\u3092\u9078\u629e\u3059\u308b\u305f\u3081\u306e\u5f37\u529b\u306a\u30c4\u30fc\u30eb\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u79d1\u5b66\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u7814\u7a76\u7d50\u679c<\/strong><\/h2>\n\n\n\n<p>\u8fd1\u5e74\u3001\u591a\u304f\u306e\u7814\u7a76\u304c\u907a\u4f1d\u5b50\u3068\u808c\u306e\u8001\u5316\u306e\u95a2\u4fc2\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MMP1\u907a\u4f1d\u5b50\u3068\u30b7\u30ef\u5f62\u6210\uff08Journal of Investigative Dermatology, 2015\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>MMP1\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u7d2b\u5916\u7dda\u306b\u3088\u308b\u30b3\u30e9\u30fc\u30b2\u30f3\u5206\u89e3\u304c\u4fc3\u9032\u3055\u308c\u3001\u30b7\u30ef\u304c\u3067\u304d\u3084\u3059\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li>\u8ad6\u6587\u30ea\u30f3\u30af<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>FOXO3\u907a\u4f1d\u5b50\u3068\u8001\u5316\u306e\u95a2\u4fc2\uff08Nature Communications, 2018\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>FOXO3\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3001\u808c\u7d30\u80de\u306e\u4fee\u5fa9\u80fd\u529b\u3084\u5bff\u547d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41467-018-04107-5\">\u8ad6\u6587\u30ea\u30f3\u30af<\/a><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>MC1R\u907a\u4f1d\u5b50\u3068\u30b7\u30df\u306e\u30ea\u30b9\u30af\uff08Pigment Cell &amp; Melanoma Research, 2017\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>MC1R\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3001\u7d2b\u5916\u7dda\u30c0\u30e1\u30fc\u30b8\u306b\u5bfe\u3059\u308b\u808c\u306e\u8010\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/pcmr.12549\">\u8ad6\u6587\u30ea\u30f3\u30af<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>4. \u808c\u306e\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u305f\u3081\u306e\u907a\u4f1d\u5b50\u306b\u57fa\u3065\u3044\u305f\u30b9\u30ad\u30f3\u30b1\u30a2\u6226\u7565<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"681\" src=\"\/gene\/wp-content\/uploads\/2025\/02\/27427792_m-1024x681.jpg\" alt=\"\u9996\u306e\u5468\u308a\u3092\u30b1\u30a2\u3059\u308b\u5973\u6027\" class=\"wp-image-6043\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/27427792_m-1024x681.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/27427792_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/27427792_m-768x511.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/27427792_m-1536x1022.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/27427792_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4.1 \u30b7\u30ef\u30fb\u305f\u308b\u307f\u5bfe\u7b56\uff1aMMP1\u3001COL1A1\u3001ELN\u907a\u4f1d\u5b50\u306b\u57fa\u3065\u304f\u30b1\u30a2<\/strong><\/h3>\n\n\n\n<p>\u30b7\u30ef\u3084\u305f\u308b\u307f\u306e\u4e3b\u306a\u539f\u56e0\u306f\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u3084\u30a8\u30e9\u30b9\u30c1\u30f3\u306e\u5206\u89e3\u306b\u3088\u308b\u808c\u306e\u5f3e\u529b\u4f4e\u4e0b\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u5206\u89e3\u901f\u5ea6\u306f\u3001MMP1\u3001COL1A1\u3001ELN\uff08\u30a8\u30e9\u30b9\u30c1\u30f3\u907a\u4f1d\u5b50\uff09\u306a\u3069\u306e\u907a\u4f1d\u5b50\u306e\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\uff081\uff09MMP1\u907a\u4f1d\u5b50\u304c\u6d3b\u6027\u5316\u3057\u3084\u3059\u3044\u4eba\u306e\u5bfe\u7b56<\/strong><\/h4>\n\n\n\n<p>MMP1\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u7d2b\u5916\u7dda\u3084\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308a\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u5206\u89e3\u304c\u65e9\u307e\u308a\u3001\u30b7\u30ef\u304c\u3067\u304d\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u63a8\u5968\u6210\u5206<\/strong>\uff1a\u30ec\u30c1\u30ce\u30fc\u30eb\uff08\u30d3\u30bf\u30df\u30f3A\u8a98\u5c0e\u4f53\uff09\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u3001\u30d3\u30bf\u30df\u30f3C<\/li>\n\n\n\n<li><strong>\u751f\u6d3b\u7fd2\u6163<\/strong>\uff1a\u7d2b\u5916\u7dda\u5bfe\u7b56\u3092\u5fb9\u5e95\u3057\u3001\u6297\u9178\u5316\u98df\u54c1\uff08\u30d6\u30eb\u30fc\u30d9\u30ea\u30fc\u3001\u7dd1\u8336\u306a\u3069\uff09\u3092\u6442\u53d6\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\uff082\uff09COL1A1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba\u306e\u5bfe\u7b56<\/strong><\/h4>\n\n\n\n<p>COL1A1\u907a\u4f1d\u5b50\u304c\u5909\u7570\u3057\u3066\u3044\u308b\u3068\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u751f\u6210\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u3001\u305f\u308b\u307f\u3084\u30cf\u30ea\u306e\u6e1b\u5c11\u304c\u8d77\u3053\u308a\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u63a8\u5968\u6210\u5206<\/strong>\uff1a\u30b3\u30e9\u30fc\u30b2\u30f3\u30da\u30d7\u30c1\u30c9\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u3001\u30da\u30d7\u30c1\u30c9\u6210\u5206<\/li>\n\n\n\n<li><strong>\u751f\u6d3b\u7fd2\u6163<\/strong>\uff1a\u9069\u5ea6\u306a\u904b\u52d5\u3067\u8840\u6d41\u3092\u4fc3\u9032\u3057\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u751f\u6210\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u98df\u54c1\uff08\u9b5a\u3001\u8c46\u985e\uff09\u3092\u6442\u53d6\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\uff083\uff09ELN\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3068\u30a8\u30e9\u30b9\u30c1\u30f3\u306e\u7dad\u6301<\/strong><\/h4>\n\n\n\n<p>\u30a8\u30e9\u30b9\u30c1\u30f3\u306f\u808c\u306e\u5f3e\u529b\u3092\u4fdd\u3064\u91cd\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3001ELN\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u751f\u6210\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u30a8\u30e9\u30b9\u30c1\u30f3\u306e\u5408\u6210\u304c\u4f4e\u4e0b\u3057\u3001\u305f\u308b\u307f\u304c\u8d77\u3053\u308a\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u63a8\u5968\u6210\u5206<\/strong>\uff1a\u30a8\u30e9\u30b9\u30c1\u30f3\u30da\u30d7\u30c1\u30c9\u3001\u30d3\u30bf\u30df\u30f3C\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9<\/li>\n\n\n\n<li><strong>\u751f\u6d3b\u7fd2\u6163<\/strong>\uff1a\u9069\u5ea6\u306a\u30de\u30c3\u30b5\u30fc\u30b8\u3084\u9854\u306e\u7b4b\u8089\u3092\u935b\u3048\u308b\u30a8\u30af\u30b5\u30b5\u30a4\u30ba\u3092\u884c\u3046\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4.2 \u30b7\u30df\u30fb\u304f\u3059\u307f\u5bfe\u7b56\uff1aMC1R\u3001TYR\u3001SLC45A2\u907a\u4f1d\u5b50\u306b\u57fa\u3065\u304f\u30b1\u30a2<\/strong><\/h3>\n\n\n\n<p>\u30b7\u30df\u3084\u304f\u3059\u307f\u306e\u539f\u56e0\u306f\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u306e\u904e\u5270\u3084\u7d2b\u5916\u7dda\u30c0\u30e1\u30fc\u30b8\u306b\u3088\u308b\u8272\u7d20\u6c88\u7740\u3067\u3059\u3002MC1R\u3001TYR\uff08\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u907a\u4f1d\u5b50\uff09\u3001SLC45A2\u907a\u4f1d\u5b50\u304c\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u306e\u8abf\u6574\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\uff081\uff09MC1R\u907a\u4f1d\u5b50\u3068\u7d2b\u5916\u7dda\u8010\u6027\u306e\u9055\u3044<\/strong><\/h4>\n\n\n\n<p>MC1R\u907a\u4f1d\u5b50\u304c\u5909\u7570\u3057\u3066\u3044\u308b\u3068\u3001\u7d2b\u5916\u7dda\u306b\u5bfe\u3059\u308b\u808c\u306e\u9632\u5fa1\u529b\u304c\u4f4e\u4e0b\u3057\u3001\u30b7\u30df\u304c\u3067\u304d\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u63a8\u5968\u6210\u5206<\/strong>\uff1a\u30d3\u30bf\u30df\u30f3C\u3001\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178\u3001\u30a2\u30eb\u30d6\u30c1\u30f3<\/li>\n\n\n\n<li><strong>\u751f\u6d3b\u7fd2\u6163<\/strong>\uff1aSPF50+\u306e\u65e5\u713c\u3051\u6b62\u3081\u3092\u4f7f\u7528\u3057\u3001UV\u30ab\u30c3\u30c8\u52b9\u679c\u306e\u3042\u308b\u8863\u985e\u3092\u6d3b\u7528\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\uff082\uff09TYR\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u3068\u30e1\u30e9\u30cb\u30f3\u751f\u6210<\/strong><\/h4>\n\n\n\n<p>TYR\u907a\u4f1d\u5b50\u306f\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u306b\u95a2\u4e0e\u3059\u308b\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002\u6d3b\u6027\u304c\u9ad8\u3044\u3068\u30e1\u30e9\u30cb\u30f3\u304c\u751f\u6210\u3055\u308c\u3084\u3059\u304f\u3001\u30b7\u30df\u306e\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u63a8\u5968\u6210\u5206<\/strong>\uff1a\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u3001\u30d3\u30bf\u30df\u30f3C\u8a98\u5c0e\u4f53\u3001\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3<\/li>\n\n\n\n<li><strong>\u751f\u6d3b\u7fd2\u6163<\/strong>\uff1a\u6297\u9178\u5316\u4f5c\u7528\u306e\u3042\u308b\u98df\u54c1\uff08\u30c8\u30de\u30c8\u3001\u30a2\u30dc\u30ab\u30c9\uff09\u3092\u6442\u53d6\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\uff083\uff09SLC45A2\u907a\u4f1d\u5b50\u3068\u808c\u306e\u8272\u7d20\u6c88\u7740<\/strong><\/h4>\n\n\n\n<p>SLC45A2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u808c\u306e\u8272\u7d20\u6c88\u7740\u306e\u5ea6\u5408\u3044\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u8272\u7d20\u6c88\u7740\u304c\u6fc3\u304f\u306a\u308a\u3084\u3059\u3044\u305f\u3081\u3001\u5fb9\u5e95\u7684\u306a\u7f8e\u767d\u30b1\u30a2\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u63a8\u5968\u6210\u5206<\/strong>\uff1a\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u3001\u30a2\u30eb\u30d6\u30c1\u30f3\u3001\u30d7\u30e9\u30bb\u30f3\u30bf\u30a8\u30ad\u30b9<\/li>\n\n\n\n<li><strong>\u751f\u6d3b\u7fd2\u6163<\/strong>\uff1a\u30d4\u30fc\u30ea\u30f3\u30b0\u3084\u30ec\u30fc\u30b6\u30fc\u6cbb\u7642\u3092\u691c\u8a0e\u3057\u3001\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u3092\u4fc3\u9032\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4.3 \u4fdd\u6e7f\u30fb\u30d0\u30ea\u30a2\u6a5f\u80fd\u5f37\u5316\uff1aFLG\u3001AQP3\u3001SPINK5\u907a\u4f1d\u5b50\u306b\u57fa\u3065\u304f\u30b1\u30a2<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/4931959_m-1024x683.jpg\" alt=\"\" class=\"wp-image-3061\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4931959_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4931959_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4931959_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4931959_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4931959_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u808c\u306e\u4e7e\u71e5\u3084\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u4f4e\u4e0b\u306f\u3001\u30b7\u30ef\u3084\u808c\u8352\u308c\u306e\u539f\u56e0\u306b\u306a\u308a\u307e\u3059\u3002FLG\uff08\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u907a\u4f1d\u5b50\uff09\u3001AQP3\uff08\u30a2\u30af\u30a2\u30dd\u30ea\u30f3\u907a\u4f1d\u5b50\uff09\u3001SPINK5\uff08\u76ae\u819a\u30d0\u30ea\u30a2\u95a2\u9023\u907a\u4f1d\u5b50\uff09\u304c\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\uff081\uff09FLG\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3068\u4e7e\u71e5\u808c<\/strong><\/h4>\n\n\n\n<p>FLG\u907a\u4f1d\u5b50\u304c\u5909\u7570\u3057\u3066\u3044\u308b\u3068\u3001\u76ae\u819a\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u6c34\u5206\u304c\u84b8\u767a\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u63a8\u5968\u6210\u5206<\/strong>\uff1a\u30bb\u30e9\u30df\u30c9\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u3001\u30b7\u30a2\u30d0\u30bf\u30fc<\/li>\n\n\n\n<li><strong>\u751f\u6d3b\u7fd2\u6163<\/strong>\uff1a\u904e\u5ea6\u306a\u6d17\u9854\u3092\u907f\u3051\u3001\u4fdd\u6e7f\u30af\u30ea\u30fc\u30e0\u3092\u3053\u307e\u3081\u306b\u4f7f\u7528\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\uff082\uff09AQP3\u907a\u4f1d\u5b50\u3068\u6c34\u5206\u4fdd\u6301\u80fd\u529b<\/strong><\/h4>\n\n\n\n<p>AQP3\u907a\u4f1d\u5b50\u306f\u3001\u6c34\u5206\u3092\u7d30\u80de\u306b\u8f38\u9001\u3059\u308b\u30a2\u30af\u30a2\u30dd\u30ea\u30f33\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u304c\u5909\u7570\u3059\u308b\u3068\u3001\u6c34\u5206\u4fdd\u6301\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u3001\u808c\u306e\u5f3e\u529b\u304c\u5931\u308f\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u63a8\u5968\u6210\u5206<\/strong>\uff1a\u30b0\u30ea\u30bb\u30ea\u30f3\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u3001\u5c3f\u7d20<\/li>\n\n\n\n<li><strong>\u751f\u6d3b\u7fd2\u6163<\/strong>\uff1a\u52a0\u6e7f\u5668\u3092\u4f7f\u7528\u3057\u3001\u5341\u5206\u306a\u6c34\u5206\u88dc\u7d66\u3092\u5fc3\u304c\u3051\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\uff083\uff09SPINK5\u907a\u4f1d\u5b50\u3068\u654f\u611f\u808c<\/strong><\/h4>\n\n\n\n<p>SPINK5\u907a\u4f1d\u5b50\u304c\u5909\u7570\u3059\u308b\u3068\u3001\u808c\u306e\u9632\u5fa1\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u5916\u90e8\u523a\u6fc0\u306b\u654f\u611f\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u63a8\u5968\u6210\u5206<\/strong>\uff1a\u30a2\u30e9\u30f3\u30c8\u30a4\u30f3\u3001\u30d1\u30f3\u30c6\u30ce\u30fc\u30eb\u3001\u30c4\u30dc\u30af\u30b5\u30a8\u30ad\u30b9<\/li>\n\n\n\n<li><strong>\u751f\u6d3b\u7fd2\u6163<\/strong>\uff1a\u4f4e\u523a\u6fc0\u306e\u30b9\u30ad\u30f3\u30b1\u30a2\u88fd\u54c1\u3092\u4f7f\u7528\u3057\u3001\u904e\u5ea6\u306a\u6469\u64e6\u3092\u907f\u3051\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>5. \u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u304f\u7f8e\u5bb9\u533b\u7642\u306e\u9032\u5316<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/30813573_m-1024x683.jpg\" alt=\"\" class=\"wp-image-8732\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/30813573_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/30813573_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/30813573_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/30813573_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/30813573_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u89e3\u6790\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u7f8e\u5bb9\u533b\u7642\u306e\u5206\u91ce\u3067\u306f\u500b\u5225\u5316\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u5f93\u6765\u306e\u753b\u4e00\u7684\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u3084\u6cbb\u7642\u304b\u3089\u3001\u3088\u308a\u52b9\u679c\u7684\u3067\u526f\u4f5c\u7528\u306e\u5c11\u306a\u3044\u65bd\u8853\u3078\u3068\u9032\u5316\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5.1 \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u7f8e\u5bb9\u65bd\u8853\u306e\u9078\u629e<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u3063\u3066\u808c\u8cea\u3084\u8001\u5316\u306e\u9032\u884c\u5ea6\u304c\u628a\u63e1\u3067\u304d\u308b\u305f\u3081\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u7f8e\u5bb9\u65bd\u8853\u306e\u6700\u9069\u5316\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\uff081\uff09\u30ec\u30fc\u30b6\u30fc\u6cbb\u7642\u306e\u9069\u5fdc\u8a55\u4fa1<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MC1R\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong>\u306f\u3001\u30ec\u30fc\u30b6\u30fc\u6cbb\u7642\u5f8c\u306e\u708e\u75c7\u5f8c\u8272\u7d20\u6c88\u7740\uff08PIH\uff09\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u305f\u3081\u3001\u4f4e\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u30ec\u30fc\u30b6\u30fc\u3084IPL\uff08\u5149\u6cbb\u7642\uff09\u304c\u63a8\u5968\u3055\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>TYR\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u4eba<\/strong>\u306f\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u304c\u6d3b\u767a\u306a\u305f\u3081\u3001\u30ec\u30fc\u30b6\u30fc\u6cbb\u7642\u5f8c\u306b\u7f8e\u767d\u30b1\u30a2\u3092\u5f37\u5316\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\uff082\uff09\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u30fb\u30dc\u30c8\u30c3\u30af\u30b9\u306e\u52b9\u679c\u306e\u500b\u4eba\u5dee<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>COL1A1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong>\u306f\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u6ce8\u5165\u306e\u6301\u7d9a\u6642\u9593\u304c\u77ed\u304f\u306a\u308b\u50be\u5411\u304c\u3042\u308a\u3001\u901a\u5e38\u3088\u308a\u3082\u65e9\u3081\u306e\u8ffd\u52a0\u65bd\u8853\u304c\u5fc5\u8981\u306b\u306a\u308b\u5834\u5408\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>MMP1\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u4eba<\/strong>\u306f\u3001\u30dc\u30c8\u30c3\u30af\u30b9\u306e\u52b9\u679c\u304c\u77ed\u7e2e\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u9069\u5207\u306a\u6295\u4e0e\u91cf\u306e\u8abf\u6574\u304c\u6c42\u3081\u3089\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\uff083\uff09PRP\uff08\u591a\u8840\u5c0f\u677f\u8840\u6f3f\uff09\u7642\u6cd5\u306e\u9069\u5fdc\u8a55\u4fa1<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FOXO3\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong>\u306f\u3001\u7d30\u80de\u306e\u4fee\u5fa9\u80fd\u529b\u304c\u4f4e\u3044\u305f\u3081\u3001PRP\u7642\u6cd5\u306e\u52b9\u679c\u304c\u9ad8\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>SOD2\u907a\u4f1d\u5b50\u306e\u6297\u9178\u5316\u80fd\u529b\u304c\u4f4e\u3044\u4eba<\/strong>\u306f\u3001PRP\u306b\u3088\u308b\u518d\u751f\u80fd\u529b\u306e\u5411\u4e0a\u304c\u7279\u306b\u6709\u52b9\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5.2 \u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u304f\u30aa\u30fc\u30c0\u30fc\u30e1\u30a4\u30c9\u30b9\u30ad\u30f3\u30b1\u30a2<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u7d50\u679c\u3092\u3082\u3068\u306b\u3001\u4e00\u4eba\u3072\u3068\u308a\u306b\u6700\u9069\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u88fd\u54c1\u3092\u51e6\u65b9\u3059\u308b\u30b5\u30fc\u30d3\u30b9\u304c\u5897\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\uff081\uff09\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u7f8e\u5bb9\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30b3\u30e9\u30fc\u30b2\u30f3\u5206\u89e3\u304c\u9032\u307f\u3084\u3059\u3044\u4eba<\/strong> \u2192 \u30b3\u30e9\u30fc\u30b2\u30f3\u30da\u30d7\u30c1\u30c9\uff0b\u30d3\u30bf\u30df\u30f3C<\/li>\n\n\n\n<li><strong>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u5f37\u3044\u4eba<\/strong> \u2192 \u30a2\u30b9\u30bf\u30ad\u30b5\u30f3\u30c1\u30f3\uff0b\u30d3\u30bf\u30df\u30f3E<\/li>\n\n\n\n<li><strong>\u4e7e\u71e5\u3057\u3084\u3059\u3044\u4eba<\/strong> \u2192 \u30bb\u30e9\u30df\u30c9\uff0b\u30d2\u30a2\u30eb\u30ed\u30f3\u9178<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\uff082\uff09\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u305f\u30b9\u30ad\u30f3\u30b1\u30a2\u88fd\u54c1<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7f8e\u5bb9\u696d\u754c\u3067\u306f\u3001AI\u3068\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u30ab\u30b9\u30bf\u30e0\u30b9\u30ad\u30f3\u30b1\u30a2\u304c\u767b\u5834\u3057\u3066\u3044\u308b\u3002<\/strong><\/li>\n\n\n\n<li>\u4f8b\u3048\u3070\u3001\u30ed\u30ec\u30a2\u30eb\u3084\u30d7\u30ed\u30af\u30bf\u30fc\uff06\u30ae\u30e3\u30f3\u30d6\u30eb\uff08P&amp;G\uff09\u306f\u3001\u6d88\u8cbb\u8005\u306e\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u57fa\u306b\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u3055\u308c\u305f\u7f8e\u5bb9\u88fd\u54c1\u3092\u958b\u767a\u3057\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>6. \u907a\u4f1d\u5b50\u7f8e\u5bb9\u306e\u672a\u6765\u3068\u7814\u7a76\u52d5\u5411<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/30813570_m-1024x683.jpg\" alt=\"\" class=\"wp-image-8739\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/30813570_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/30813570_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/30813570_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/30813570_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/30813570_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7f8e\u5bb9\u306e\u5206\u91ce\u306f\u6025\u901f\u306b\u767a\u5c55\u3057\u3066\u304a\u308a\u3001\u65b0\u305f\u306a\u6280\u8853\u304c\u6b21\u3005\u3068\u767b\u5834\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u9032\u3080\u3053\u3068\u3067\u3001\u3088\u308a\u7cbe\u5bc6\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u3084\u7f8e\u5bb9\u533b\u7642\u304c\u5b9f\u73fe\u3059\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6.1 \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3068\u7f8e\u5bb9<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CRISPR-Cas9\u6280\u8853\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u304c\u9032\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u8001\u5316\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u306e\u4fee\u6b63\u304c\u53ef\u80fd\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li>\u4f8b\u3048\u3070\u3001MMP1\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u3092\u6291\u5236\u3057\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u5206\u89e3\u3092\u9045\u3089\u305b\u308b\u6280\u8853\u304c\u958b\u767a\u3055\u308c\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u30b9\u30ad\u30f3\u30b1\u30a2<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\uff08\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u8abf\u7bc0\uff09\u306f\u3001\u751f\u6d3b\u7fd2\u6163\u3084\u74b0\u5883\u8981\u56e0\u306b\u3088\u3063\u3066\u5909\u5316\u3059\u308b\u3002<\/li>\n\n\n\n<li>\u4f8b\u3048\u3070\u3001\u30b9\u30c8\u30ec\u30b9\u3084\u98df\u751f\u6d3b\u306e\u6539\u5584\u306b\u3088\u3063\u3066\u3001\u6297\u9178\u5316\u907a\u4f1d\u5b50\uff08SOD2\u3084GPX1\uff09\u306e\u767a\u73fe\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6.2 AI\u3068\u907a\u4f1d\u5b50\u7f8e\u5bb9\u306e\u7d71\u5408<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AI\u3092\u6d3b\u7528\u3057\u305f\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u7f8e\u5bb9\u8a3a\u65ad<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>AI\u304c\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3057\u3001\u6700\u9069\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u3084\u6cbb\u7642\u6cd5\u3092\u63d0\u6848\u3059\u308b\u30b7\u30b9\u30c6\u30e0\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li>\u4f8b\u3048\u3070\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u7d50\u679c\u3092\u30b9\u30de\u30fc\u30c8\u30d5\u30a9\u30f3\u30a2\u30d7\u30ea\u3067\u7ba1\u7406\u3057\u3001\u808c\u306e\u72b6\u614b\u306b\u5fdc\u3058\u3066\u63a8\u5968\u6210\u5206\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u8abf\u6574\u3067\u304d\u308b\u6280\u8853\u304c\u9032\u3093\u3067\u3044\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30d0\u30a4\u30aa\u30bb\u30f3\u30b5\u30fc\u6280\u8853\u306e\u767a\u5c55<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u808c\u306e\u72b6\u614b\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u6e2c\u5b9a\u3059\u308b\u30a6\u30a7\u30a2\u30e9\u30d6\u30eb\u30c7\u30d0\u30a4\u30b9\u304c\u767b\u5834\u3057\u3064\u3064\u3042\u308b\u3002<\/li>\n\n\n\n<li>\u907a\u4f1d\u5b50\u60c5\u5831\u3068\u9023\u643a\u3057\u3001\u6700\u9069\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u3084\u7f8e\u5bb9\u65bd\u8853\u3092\u81ea\u52d5\u7684\u306b\u63d0\u6848\u3059\u308b\u30b7\u30b9\u30c6\u30e0\u304c\u958b\u767a\u4e2d\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>7. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u969b\u306e\u502b\u7406\u7684\u8ab2\u984c<\/strong><\/h2>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7f8e\u5bb9\u306e\u666e\u53ca\u306b\u4f34\u3044\u3001\u3044\u304f\u3064\u304b\u306e\u502b\u7406\u7684\u306a\u554f\u984c\u3082\u6d6e\u4e0a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7.1 \u907a\u4f1d\u60c5\u5831\u306e\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u4fdd\u8b77<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u60c5\u5831\u306f\u975e\u5e38\u306b\u6a5f\u5bc6\u6027\u306e\u9ad8\u3044\u30c7\u30fc\u30bf\u3067\u3042\u308a\u3001\u9069\u5207\u306a\u7ba1\u7406\u304c\u6c42\u3081\u3089\u308c\u308b\u3002<\/strong><\/li>\n\n\n\n<li>\u4e00\u90e8\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u4f1a\u793e\u304c\u3001\u9867\u5ba2\u306e\u907a\u4f1d\u60c5\u5831\u3092\u7b2c\u4e09\u8005\u306b\u8ca9\u58f2\u3057\u3066\u3044\u308b\u30b1\u30fc\u30b9\u3082\u3042\u308a\u3001\u30c7\u30fc\u30bf\u4fdd\u8b77\u306e\u5fc5\u8981\u6027\u304c\u5f37\u8abf\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7.2 \u907a\u4f1d\u5b50\u5dee\u5225\u306e\u30ea\u30b9\u30af<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u7f8e\u5bb9\u304c\u4e00\u822c\u5316\u3059\u308b\u3068\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u3092\u6301\u3064\u4eba\u304c\u7f8e\u5bb9\u5e02\u5834\u3067\u512a\u4f4d\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/strong><\/li>\n\n\n\n<li>\u4f8b\u3048\u3070\u3001\u300c\u30b3\u30e9\u30fc\u30b2\u30f3\u751f\u6210\u304c\u512a\u308c\u3066\u3044\u308b\u907a\u4f1d\u5b50\u3092\u6301\u3064\u4eba\u304c\u7f8e\u3057\u304f\u306a\u308a\u3084\u3059\u3044\u300d\u3068\u3044\u3063\u305f\u504f\u898b\u304c\u751f\u307e\u308c\u308b\u30ea\u30b9\u30af\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7.3 \u533b\u7642\u3068\u7f8e\u5bb9\u306e\u5883\u754c\u7dda<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u304c\u533b\u5b66\u7684\u8a3a\u65ad\u306e\u4ee3\u66ff\u3068\u306a\u308b\u3079\u304d\u3067\u306f\u306a\u3044\u3068\u3044\u3046\u8b70\u8ad6\u304c\u3042\u308b\u3002<\/strong><\/li>\n\n\n\n<li>\u7f8e\u5bb9\u76ee\u7684\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u3068\u3001\u533b\u7642\u76ee\u7684\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u5883\u754c\u3092\u660e\u78ba\u306b\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>8. \u907a\u4f1d\u5b50\u89e3\u6790\u3092\u6d3b\u7528\u3057\u305f\u5316\u7ca7\u54c1\u306e\u6700\u524d\u7dda<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"724\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/2469840_m-1024x724.jpg\" alt=\"\" class=\"wp-image-8498\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2469840_m-1024x724.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2469840_m-300x212.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2469840_m-768x543.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2469840_m-1536x1086.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2469840_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30b9\u30ad\u30f3\u30b1\u30a2\u88fd\u54c1\u306e\u958b\u767a\u304c\u9032\u3093\u3067\u304a\u308a\u3001\u5404\u7a2e\u30d6\u30e9\u30f3\u30c9\u304c\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u3044\u305f\u7f8e\u5bb9\u6210\u5206\u306e\u6700\u9069\u5316\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8.1 \u907a\u4f1d\u5b50\u30b9\u30ad\u30e3\u30f3\u3092\u7528\u3044\u305f\u30b9\u30ad\u30f3\u30b1\u30a2\u88fd\u54c1\u306e\u958b\u767a<\/strong><\/h3>\n\n\n\n<p>\u5316\u7ca7\u54c1\u696d\u754c\u3067\u306f\u3001\u907a\u4f1d\u5b50\u30b9\u30ad\u30e3\u30f3\u3092\u6d3b\u7528\u3057\u3001\u500b\u4eba\u306e\u808c\u8cea\u3084\u8001\u5316\u30ea\u30b9\u30af\u306b\u5408\u308f\u305b\u305f\u5316\u7ca7\u54c1\u3092\u63d0\u4f9b\u3059\u308b\u53d6\u308a\u7d44\u307f\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8cc7\u751f\u5802\u306e\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30fb\u30b9\u30ad\u30f3\u30b1\u30a2<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u89e3\u6790\u306b\u57fa\u3065\u3044\u3066\u3001\u808c\u306e\u5f3e\u529b\u3084\u30b7\u30ef\u3001\u30b7\u30df\u306e\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3057\u3001\u6700\u9069\u306a\u7f8e\u5bb9\u6210\u5206\u3092\u51e6\u65b9\u3059\u308b\u30b5\u30fc\u30d3\u30b9\u3092\u958b\u767a\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30ed\u30ec\u30a2\u30eb\u306e\u907a\u4f1d\u5b50\u5206\u6790\u306b\u3088\u308b\u30ab\u30b9\u30bf\u30e0\u7f8e\u5bb9\u6db2<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30e6\u30fc\u30b6\u30fc\u306eDNA\u30b5\u30f3\u30d7\u30eb\u3092\u89e3\u6790\u3057\u3001\u6297\u9178\u5316\u529b\u3084\u76ae\u8102\u5206\u6ccc\u91cf\u3092\u8003\u616e\u3057\u305f\u7f8e\u5bb9\u6db2\u3092\u8abf\u5408\u3059\u308b\u6280\u8853\u3092\u767a\u8868\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8.2 \u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u304f\u30b9\u30ad\u30f3\u30b1\u30a2\u6210\u5206\u306e\u9078\u629e<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u3082\u3068\u306b\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u6210\u5206\u306e\u6700\u9069\u5316\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6297\u9178\u5316\u907a\u4f1d\u5b50\uff08SOD2, GPX1\uff09\u306e\u6d3b\u6027\u304c\u4f4e\u3044\u4eba\u5411\u3051<\/strong> \u2192 \u30a2\u30b9\u30bf\u30ad\u30b5\u30f3\u30c1\u30f3\u3001\u30d3\u30bf\u30df\u30f3E\u3001\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u914d\u5408\u306e\u7f8e\u5bb9\u6db2<\/li>\n\n\n\n<li><strong>\u30b3\u30e9\u30fc\u30b2\u30f3\u5206\u89e3\u304c\u9032\u307f\u3084\u3059\u3044\uff08MMP1\u306e\u6d3b\u6027\u304c\u9ad8\u3044\uff09\u4eba\u5411\u3051<\/strong> \u2192 \u30da\u30d7\u30c1\u30c9\u3001\u30d3\u30bf\u30df\u30f3C\u3001\u30ec\u30c1\u30ce\u30fc\u30eb\u3092\u5f37\u5316\u3057\u305f\u30af\u30ea\u30fc\u30e0<\/li>\n\n\n\n<li><strong>\u4fdd\u6e7f\u6a5f\u80fd\u304c\u4f4e\u3044\uff08FLG\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308b\uff09\u4eba\u5411\u3051<\/strong> \u2192 \u30bb\u30e9\u30df\u30c9\u3001\u30b9\u30af\u30ef\u30e9\u30f3\u3001\u30b0\u30ea\u30bb\u30ea\u30f3\u3092\u9ad8\u6fc3\u5ea6\u914d\u5408\u3057\u305f\u4fdd\u6e7f\u30af\u30ea\u30fc\u30e0<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8.3 \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u30a4\u30f3\u30ca\u30fc\u30b1\u30a2\u88fd\u54c1\u306e\u958b\u767a<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u3092\u6d3b\u7528\u3057\u3001\u808c\u306e\u5065\u5eb7\u3092\u5185\u5074\u304b\u3089\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u7814\u7a76\u3082\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30b3\u30e9\u30fc\u30b2\u30f3\u751f\u6210\u3092\u4fc3\u9032\u3059\u308b\u305f\u3081\u306e\u6804\u990a\u88dc\u52a9\u98df\u54c1<\/strong>\n<ul class=\"wp-block-list\">\n<li>COL1A1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba\u5411\u3051\u306b\u3001\u30d3\u30bf\u30df\u30f3C\u3068\u9244\u3092\u914d\u5408\u3057\u305f\u30b3\u30e9\u30fc\u30b2\u30f3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u63a8\u5968\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3092\u6291\u5236\u3059\u308b\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8<\/strong>\n<ul class=\"wp-block-list\">\n<li>TYR\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u4eba\u5411\u3051\u306b\u3001\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u3084L-\u30b7\u30b9\u30c6\u30a4\u30f3\u3092\u914d\u5408\u3057\u305f\u7f8e\u767d\u7cfb\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u63d0\u4f9b\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>9. \u907a\u4f1d\u5b50\u7f8e\u5bb9\u3068\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"681\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/30624755_m-1024x681.jpg\" alt=\"\" class=\"wp-image-8754\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30624755_m-1024x681.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30624755_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30624755_m-768x511.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30624755_m-1536x1022.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30624755_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306f\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u305d\u308c\u304c\u808c\u306e\u5065\u5eb7\u72b6\u614b\u306b\u76f4\u7d50\u3057\u307e\u3059\u3002\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3084\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u306e\u5206\u6ccc\u91cf\u3092\u8abf\u7bc0\u3059\u308b\u907a\u4f1d\u5b50\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u3001\u808c\u306e\u30c8\u30e9\u30d6\u30eb\u306e\u8d77\u3053\u308a\u3084\u3059\u3055\u304c\u5909\u308f\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9.1 \u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3068\u808c\u306e\u5f3e\u529b\uff1aESR1\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306f\u30b3\u30e9\u30fc\u30b2\u30f3\u751f\u6210\u3092\u4fc3\u9032\u3057\u3001\u808c\u306e\u5f3e\u529b\u3092\u7dad\u6301\u3059\u308b\u91cd\u8981\u306a\u30db\u30eb\u30e2\u30f3\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ESR1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong>\u306f\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u53d7\u5bb9\u4f53\u611f\u53d7\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u9589\u7d4c\u5f8c\u306b\u808c\u306e\u30cf\u30ea\u304c\u6025\u6fc0\u306b\u4f4e\u4e0b\u3059\u308b\u50be\u5411\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u5bfe\u7b56<\/strong>\uff1a\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u3092\u542b\u3080\u98df\u54c1\uff08\u5927\u8c46\u88fd\u54c1\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3057\u3001\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9.2 \u76ae\u8102\u5206\u6ccc\u3068\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\uff1aSRD5A2\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\uff08\u7537\u6027\u30db\u30eb\u30e2\u30f3\uff09\u306f\u76ae\u8102\u5206\u6ccc\u3092\u6d3b\u6027\u5316\u3055\u305b\u3001\u30cb\u30ad\u30d3\u3084\u6bdb\u7a74\u306e\u958b\u304d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>SRD5A2\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u4eba<\/strong>\u306f\u3001\u76ae\u8102\u306e\u5206\u6ccc\u91cf\u304c\u591a\u304f\u3001\u8102\u6027\u808c\u306b\u306a\u308a\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u5bfe\u7b56<\/strong>\uff1a\u30d3\u30bf\u30df\u30f3B6\u3092\u542b\u3080\u98df\u54c1\u3092\u6442\u53d6\u3057\u3001\u76ae\u8102\u306e\u904e\u5270\u5206\u6ccc\u3092\u6291\u5236\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9.3 \u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u3068\u808c\u8352\u308c\uff1aNR3C1\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\uff08\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\uff09\u306e\u5206\u6ccc\u91cf\u3082\u907a\u4f1d\u7684\u306b\u7570\u306a\u308a\u3001\u808c\u30c8\u30e9\u30d6\u30eb\u306e\u539f\u56e0\u3068\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>NR3C1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong>\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u304c\u9ad8\u304f\u3001\u808c\u8352\u308c\u304c\u8d77\u3053\u308a\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u5bfe\u7b56<\/strong>\uff1a\u9069\u5ea6\u306a\u904b\u52d5\u3001\u30e8\u30ac\u3001\u7791\u60f3\u3092\u53d6\u308a\u5165\u308c\u3001\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u3092\u5f37\u5316\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>10. \u907a\u4f1d\u5b50\u89e3\u6790\u3068\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u95a2\u4fc2\uff1a\u7f8e\u808c\u3068\u8178\u5185\u74b0\u5883<\/strong><\/h2>\n\n\n\n<p>\u808c\u306e\u5065\u5eb7\u306f\u8178\u5185\u74b0\u5883\u3068\u5bc6\u63a5\u306b\u95a2\u308f\u3063\u3066\u304a\u308a\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u30d0\u30e9\u30f3\u30b9\u306f\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u3082\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10.1 \u8178\u5185\u7d30\u83cc\u3068\u808c\u8cea\u306e\u95a2\u9023\u6027<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Prevotella\u83cc\u304c\u591a\u3044\u4eba<\/strong> \u2192 \u70ad\u6c34\u5316\u7269\u306e\u6d88\u5316\u80fd\u529b\u304c\u9ad8\u304f\u3001\u808c\u306e\u4fdd\u6e7f\u529b\u304c\u826f\u597d\u306a\u50be\u5411\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>Bacteroides\u83cc\u304c\u512a\u52e2\u306a\u4eba<\/strong> \u2192 \u808c\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u708e\u75c7\u3092\u8d77\u3053\u3057\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10.2 \u8178\u5185\u30d5\u30ed\u30fc\u30e9\u3092\u6574\u3048\u308b\u7f8e\u5bb9\u7fd2\u6163<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u4e73\u9178\u83cc\u30fb\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\uff09\u306e\u6442\u53d6<\/strong> \u2192 \u8178\u5185\u306e\u5584\u7389\u83cc\u3092\u5897\u3084\u3057\u3001\u808c\u306e\u708e\u75c7\u3092\u6291\u3048\u308b\u3002<\/li>\n\n\n\n<li><strong>\u98df\u7269\u7e4a\u7dad\u306e\u6442\u53d6<\/strong> \u2192 \u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u6574\u3048\u3001\u808c\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u3092\u6b63\u5e38\u5316\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10.3 \u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308b\u8178\u5185\u74b0\u5883\u306e\u6700\u9069\u5316<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FUT2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong>\u306f\u3001\u7279\u5b9a\u306e\u8178\u5185\u7d30\u83cc\u304c\u5b9a\u7740\u3057\u306b\u304f\u3044\u305f\u3081\u3001\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u306e\u88dc\u52a9\u304c\u5fc5\u8981\u3002<\/li>\n\n\n\n<li><strong>LCT\u907a\u4f1d\u5b50\uff08\u4e73\u7cd6\u5206\u89e3\u9175\u7d20\uff09\u306b\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong>\u306f\u3001\u4e73\u7cd6\u3092\u9069\u5207\u306b\u5206\u89e3\u3067\u304d\u306a\u3044\u305f\u3081\u3001\u4e73\u88fd\u54c1\u306e\u6442\u53d6\u3092\u63a7\u3048\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>11. \u907a\u4f1d\u5b50\u7f8e\u5bb9\u3068\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\uff1a\u74b0\u5883\u8981\u56e0\u304c\u808c\u306e\u8001\u5316\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/30465243_m-1024x683.jpg\" alt=\"\u7f8e\u9854\u30ed\u30fc\u30e9\u30fc\u3092\u982c\u306b\u4f7f\u3046\u30b7\u30cb\u30a2\u5973\u6027\" class=\"wp-image-3335\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30465243_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30465243_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30465243_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30465243_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30465243_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306f\u56fa\u5b9a\u3055\u308c\u305f\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u751f\u6d3b\u7fd2\u6163\u3084\u74b0\u5883\u8981\u56e0\u306b\u3088\u3063\u3066\u305d\u306e\u50cd\u304d\u304c\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u300c\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\uff08\u5f8c\u6210\u907a\u4f1d\u5b66\uff09\u300d\u306e\u6982\u5ff5\u306f\u3001\u7f8e\u5bb9\u5206\u91ce\u306b\u3082\u5fdc\u7528\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>11.1 \u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u30b9\u30ad\u30f3\u30b1\u30a2<\/strong><\/h3>\n\n\n\n<p>\u7d2b\u5916\u7dda\u3001\u98df\u4e8b\u3001\u30b9\u30c8\u30ec\u30b9\u3001\u7761\u7720\u4e0d\u8db3\u306a\u3069\u306e\u8981\u56e0\u304c\u3001\u808c\u306e\u8001\u5316\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5909\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7d2b\u5916\u7dda<\/strong> \u2192 MMP1\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u3092\u4e0a\u3052\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u5206\u89e3\u3092\u4fc3\u9032\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u9ad8\u7cd6\u8cea\u98df<\/strong> \u2192 \u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308aCOL1A1\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u3092\u963b\u5bb3\u3057\u3001\u808c\u306e\u30cf\u30ea\u3092\u5931\u308f\u305b\u308b\u3002<\/li>\n\n\n\n<li><strong>\u7761\u7720\u4e0d\u8db3<\/strong> \u2192 CLOCK\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u304c\u4e71\u308c\u3001\u808c\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u304c\u4f4e\u4e0b\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>11.2 \u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3092\u6d3b\u7528\u3057\u305f\u7f8e\u5bb9\u6226\u7565<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3067\u3001\u808c\u8001\u5316\u3092\u6291\u5236\u3059\u308b\u65b9\u6cd5\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6297\u9178\u5316\u98df\u54c1\uff08\u30d3\u30bf\u30df\u30f3C\u30fb\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff09\u306e\u6442\u53d6<\/strong> \u2192 SOD2\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u9ad8\u3081\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u8efd\u6e1b\u3002<\/li>\n\n\n\n<li><strong>\u30d5\u30a1\u30b9\u30c6\u30a3\u30f3\u30b0\uff08\u65ad\u98df\uff09<\/strong> \u2192 FOXO3\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u3001\u7d30\u80de\u4fee\u5fa9\u6a5f\u80fd\u3092\u4fc3\u9032\u3002<\/li>\n\n\n\n<li><strong>\u898f\u5247\u6b63\u3057\u3044\u751f\u6d3b\u7fd2\u6163<\/strong> \u2192 CLOCK\u907a\u4f1d\u5b50\u306e\u30ea\u30ba\u30e0\u3092\u6574\u3048\u3001\u808c\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u3092\u6b63\u5e38\u5316\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>12. \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u672a\u6765\u306e\u7f8e\u5bb9\u30c8\u30ec\u30f3\u30c9<\/strong><\/h2>\n\n\n\n<p>\u7f8e\u5bb9\u696d\u754c\u3067\u306f\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u6700\u5148\u7aef\u306e\u6280\u8853\u304c\u7d9a\u3005\u3068\u767b\u5834\u3057\u3066\u304a\u308a\u3001\u4eca\u5f8c\u306e\u7f8e\u5bb9\u30c8\u30ec\u30f3\u30c9\u306b\u3082\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3068\u4e88\u6e2c\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12.1 AI\u00d7\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u306b\u3088\u308b\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u7f8e\u5bb9<\/strong><\/h3>\n\n\n\n<p>AI\u3068\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u808c\u306e\u72b6\u614b\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u306b\u5206\u6790\u3057\u3001\u6700\u9069\u306a\u7f8e\u5bb9\u30d7\u30e9\u30f3\u3092\u63d0\u6848\u3059\u308b\u30b7\u30b9\u30c6\u30e0\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30b9\u30de\u30fc\u30c8\u30df\u30e9\u30fc\u6280\u8853<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u60c5\u5831\u3068\u808c\u89e3\u6790\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3057\u3001\u30b7\u30ef\u3084\u30b7\u30df\u306e\u30ea\u30b9\u30af\u306b\u5fdc\u3058\u305f\u7f8e\u5bb9\u6210\u5206\u3092\u63a8\u5968\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>AI\u8a3a\u65ad\u30a2\u30d7\u30ea<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u7d50\u679c\u3092\u30b9\u30de\u30fc\u30c8\u30d5\u30a9\u30f3\u3067\u7ba1\u7406\u3057\u3001\u30b9\u30ad\u30f3\u30b1\u30a2\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3084\u6210\u5206\u306e\u9078\u629e\u3092\u6700\u9069\u5316\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12.2 \u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u305f\u30ab\u30b9\u30bf\u30e0\u30e1\u30a4\u30c9\u5316\u7ca7\u54c1<\/strong><\/h3>\n\n\n\n<p>\u6d88\u8cbb\u8005\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u57fa\u306b\u3001\u500b\u5225\u306b\u8abf\u5408\u3055\u308c\u305f\u5316\u7ca7\u54c1\u304c\u63d0\u4f9b\u3055\u308c\u308b\u6642\u4ee3\u304c\u5230\u6765\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30e6\u30fc\u30b6\u30fc\u306e\u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u7f8e\u5bb9\u6210\u5206\u306e\u6700\u9069\u5316<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30b3\u30e9\u30fc\u30b2\u30f3\u5206\u89e3\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba\u306b\u306f\u30da\u30d7\u30c1\u30c9\u914d\u5408\u306e\u7f8e\u5bb9\u6db2<\/li>\n\n\n\n<li>\u76ae\u8102\u5206\u6ccc\u304c\u591a\u3044\u4eba\u306b\u306f\u30de\u30c3\u30c8\u4ed5\u4e0a\u3052\u306e\u4fdd\u6e7f\u30af\u30ea\u30fc\u30e0<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>DNA\u30ab\u30d7\u30bb\u30eb\u6280\u8853<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u808c\u306e\u72b6\u614b\u306b\u5fdc\u3058\u3066\u3001\u7f8e\u5bb9\u6210\u5206\u304c\u6700\u9069\u306a\u30bf\u30a4\u30df\u30f3\u30b0\u3067\u653e\u51fa\u3055\u308c\u308b\u30ab\u30d7\u30bb\u30eb\u5316\u6280\u8853\u304c\u958b\u767a\u4e2d\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator 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