{"id":448,"date":"2024-11-14T00:56:17","date_gmt":"2024-11-14T00:56:17","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=448"},"modified":"2025-04-09T02:32:05","modified_gmt":"2025-04-09T02:32:05","slug":"alcohol-taisei-izonsei-idenshi-analysis","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/alcohol-taisei-izonsei-idenshi-analysis\/","title":{"rendered":"\u907a\u4f1d\u5b50\u691c\u67fb\u304c\u660e\u304b\u3059\u30a2\u30eb\u30b3\u30fc\u30eb\u8010\u6027\u3068\u4f9d\u5b58\u6027"},"content":{"rendered":"\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u306f\u3058\u3081\u306b<\/strong><\/h2>\n\n\n\n<p>\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u6442\u53d6\u306b\u5bfe\u3059\u308b\u4f53\u306e\u53cd\u5fdc\u306f\u4eba\u305d\u308c\u305e\u308c\u7570\u306a\u308a\u307e\u3059\u3002\u3042\u308b\u4eba\u306f\u5c11\u91cf\u306e\u9152\u3067\u3082\u9854\u304c\u8d64\u304f\u306a\u308a\u3001\u3059\u3050\u306b\u9154\u3063\u3066\u3057\u307e\u3046\u4e00\u65b9\u3067\u3001\u5225\u306e\u4eba\u306f\u5927\u91cf\u306b\u98f2\u3093\u3067\u3082\u5e73\u7136\u3068\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u9055\u3044\u306e\u80cc\u666f\u306b\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306b\u3082\u907a\u4f1d\u5b50\u304c\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u308b\u3053\u3068\u304c\u3001\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u8010\u6027\u3068\u4f9d\u5b58\u6027\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306e\u4ed5\u7d44\u307f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u6d3b\u7528\u65b9\u6cd5\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>1. \u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u306e\u4ed5\u7d44\u307f\u3068\u907a\u4f1d\u5b50\u306e\u5f79\u5272<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1-1. \u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u5206\u89e3\u904e\u7a0b<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30eb\u30b3\u30fc\u30eb\uff08\u30a8\u30bf\u30ce\u30fc\u30eb\uff09\u306f\u3001\u4f53\u5185\u3067\u4ee5\u4e0b\u306e2\u6bb5\u968e\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u7d4c\u3066\u4ee3\u8b1d\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>**\u30a2\u30eb\u30b3\u30fc\u30eb\u8131\u6c34\u7d20\u9175\u7d20\uff08ADH\uff09**\u306b\u3088\u3063\u3066\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306b\u5206\u89e3\u3055\u308c\u308b\u3002<\/li>\n\n\n\n<li>**\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u8131\u6c34\u7d20\u9175\u7d20\uff08ALDH\uff09**\u306b\u3088\u3063\u3066\u7121\u5bb3\u306a\u9162\u9178\u3078\u3068\u5909\u63db\u3055\u308c\u308b\u3002<\/li>\n<\/ol>\n\n\n\n<p>\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u304c\u6b63\u5e38\u306b\u9032\u307e\u306a\u3044\u3068\u3001\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u304c\u4f53\u5185\u306b\u84c4\u7a4d\u3057\u3001\u9854\u306e\u7d05\u6f6e\u3001\u5410\u304d\u6c17\u3001\u52d5\u60b8\u306a\u3069\u306e\u300c\u30d5\u30e9\u30c3\u30b7\u30f3\u30b0\u53cd\u5fdc\u300d\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1-2. \u30a2\u30eb\u30b3\u30fc\u30eb\u8010\u6027\u3092\u6c7a\u3081\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u4ee3\u8b1d\u80fd\u529b\u306f\u3001\u4e3b\u306b<strong>ADH1B\u907a\u4f1d\u5b50<\/strong>\u3068<strong>ALDH2\u907a\u4f1d\u5b50<\/strong>\u306b\u3088\u3063\u3066\u6c7a\u5b9a\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f79\u5272<\/strong><\/td><td><strong>\u4e3b\u306a\u30d0\u30ea\u30a2\u30f3\u30c8<\/strong><\/td><td><strong>\u7279\u5fb4<\/strong><\/td><\/tr><tr><td><strong>ADH1B<\/strong><\/td><td>\u30a2\u30eb\u30b3\u30fc\u30eb\u3092\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306b\u5909\u63db<\/td><td><em>ADH1B<\/em>\uff08Arg48His\uff09<\/td><td>\u6d3b\u6027\u304c\u9ad8\u3044\u3068\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u304c\u6025\u901f\u306b\u84c4\u7a4d\u3057\u3001\u98f2\u9152\u6642\u306e\u4e0d\u5feb\u611f\u304c\u5f37\u304f\u306a\u308b<\/td><\/tr><tr><td><strong>ALDH2<\/strong><\/td><td>\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u3092\u5206\u89e3<\/td><td><em>ALDH2<\/em>\uff08Glu504Lys\uff09<\/td><td>\u5909\u7570\u578b\uff08Lys\u578b\uff09\u3092\u6301\u3064\u3068ALDH2\u306e\u6d3b\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u30d5\u30e9\u30c3\u30b7\u30f3\u30b0\u53cd\u5fdc\u304c\u8d77\u3053\u308b<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>ALDH2\u907a\u4f1d\u5b50\u306e\u5909\u7570\uff08Lys\u578b\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u65e5\u672c\u4eba\u306e\u7d0440\uff05\u304c\u8a72\u5f53\u3059\u308b\u3068\u3055\u308c\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u8010\u6027\u304c\u4f4e\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1-3. \u907a\u4f1d\u5b50\u306b\u3088\u308b\u500b\u4eba\u5dee\u3068\u6c11\u65cf\u5dee<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30eb\u30b3\u30fc\u30eb\u8010\u6027\u306e\u9055\u3044\u306f\u3001\u6c11\u65cf\u9593\u3067\u3082\u9855\u8457\u3067\u3059\u3002\u4f8b\u3048\u3070\u3001\u6771\u30a2\u30b8\u30a2\uff08\u65e5\u672c\u3001\u4e2d\u56fd\u3001\u97d3\u56fd\uff09\u306e\u4eba\u3005\u306fALDH2\u306e\u6d3b\u6027\u304c\u4f4e\u3044\u4eba\u304c\u591a\u3044\u4e00\u65b9\u3067\u3001\u897f\u6d0b\u4eba\u306f\u307b\u3068\u3093\u3069\u304cALDH2\u6d3b\u6027\u578b\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u30a2\u30eb\u30b3\u30fc\u30eb\u8010\u6027\u306e\u5206\u5e03<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u8010\u6027\uff08ALDH2\u6d3b\u6027\u578b\uff09<\/strong>\uff1a\u6b27\u7c73\u7cfb\u3001\u30a2\u30d5\u30ea\u30ab\u7cfb<\/li>\n\n\n\n<li><strong>\u4e2d\u9593\u8010\u6027\uff08ADH1B\u6d3b\u6027\u578b\uff09<\/strong>\uff1a\u4e2d\u6771\u3001\u30a4\u30f3\u30c9<\/li>\n\n\n\n<li><strong>\u4f4e\u8010\u6027\uff08ALDH2\u4e0d\u6d3b\u6027\u578b\uff09<\/strong>\uff1a\u65e5\u672c\u3001\u4e2d\u56fd\u3001\u97d3\u56fd<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306a\u907a\u4f1d\u7684\u80cc\u666f\u304c\u3001\u5404\u56fd\u306e\u98f2\u9152\u6587\u5316\u3084\u30a2\u30eb\u30b3\u30fc\u30eb\u95a2\u9023\u75be\u60a3\u306e\u767a\u75c7\u7387\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. \u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u3068\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/4564629_m-1024x683.jpg\" alt=\"\" class=\"wp-image-7116\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4564629_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4564629_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4564629_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4564629_m-1536x1025.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4564629_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2-1. \u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u3068\u306f<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u306f\u3001\u98f2\u9152\u3092\u5236\u5fa1\u3067\u304d\u306a\u304f\u306a\u308b\u6162\u6027\u75be\u60a3\u3067\u3042\u308a\u3001\u907a\u4f1d\u3068\u74b0\u5883\u8981\u56e0\u304c\u8907\u96d1\u306b\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u3002\u4e16\u754c\u4fdd\u5065\u6a5f\u95a2\uff08WHO\uff09\u306b\u3088\u308b\u3068\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306e50\uff05\u4ee5\u4e0a\u306f\u907a\u4f1d\u7684\u8981\u56e0\u306b\u8d77\u56e0\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2-2. \u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u907a\u4f1d\u5b50\u3068\u3057\u3066\u3001\u4ee5\u4e0b\u306e\u3082\u306e\u304c\u7279\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f79\u5272<\/strong><\/td><td><strong>\u5f71\u97ff<\/strong><\/td><\/tr><tr><td><strong>GABRA2<\/strong><\/td><td>\u795e\u7d4c\u4f1d\u9054\u306e\u8abf\u7bc0<\/td><td>GABA\u53d7\u5bb9\u4f53\u306e\u611f\u53d7\u6027\u3092\u5909\u3048\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u93ae\u9759\u4f5c\u7528\u3092\u5f37\u5316<\/td><\/tr><tr><td><strong>DRD2<\/strong><\/td><td>\u30c9\u30fc\u30d1\u30df\u30f3\u53d7\u5bb9\u4f53<\/td><td>\u5831\u916c\u7cfb\u306e\u6d3b\u6027\u3092\u5909\u5316\u3055\u305b\u3001\u98f2\u9152\u306b\u3088\u308b\u5feb\u697d\u306e\u611f\u3058\u65b9\u306b\u5f71\u97ff<\/td><\/tr><tr><td><strong>CYP2E1<\/strong><\/td><td>\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u5206\u89e3<\/td><td>\u9175\u7d20\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u3068\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u5206\u89e3\u304c\u901f\u304f\u306a\u308a\u3001\u8010\u6027\u304c\u3064\u304d\u3084\u3059\u3044<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>\u7279\u306b\u3001DRD2\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\uff08A1\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u5831\u916c\u52b9\u679c\u304c\u5f37\u304f\u306a\u308a\u3001\u4f9d\u5b58\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2-3. \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u30ea\u30b9\u30af\u306e\u8a55\u4fa1<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u5229\u7528\u3059\u308c\u3070\u3001\u81ea\u5206\u304c\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u306b\u306a\u308a\u3084\u3059\u3044\u4f53\u8cea\u304b\u3069\u3046\u304b\u3092\u4e8b\u524d\u306b\u77e5\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u4ee5\u4e0b\u306e\u60c5\u5831\u304c\u5f97\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u80fd\u529b\u306e\u8a55\u4fa1\uff08ALDH2\u30fbADH1B\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u5831\u916c\u7cfb\u306e\u611f\u53d7\u6027\uff08DRD2\u30fbGABRA2\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u8010\u6027\u306e\u5f62\u6210\u30ea\u30b9\u30af\uff08CYP2E1\uff09<\/strong><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u306b\u3088\u308a\u3001\u9069\u5207\u306a\u98f2\u9152\u91cf\u3092\u77e5\u308a\u3001\u4f9d\u5b58\u75c7\u306e\u4e88\u9632\u306b\u5f79\u7acb\u3066\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30eb\u30b3\u30fc\u30eb\u5bfe\u7b56<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3-1. \u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u98f2\u9152\u7ba1\u7406<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u7d50\u679c\u3092\u3082\u3068\u306b\u3001\u98f2\u9152\u7fd2\u6163\u3092\u8abf\u6574\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50\u578b<\/strong><\/td><td><strong>\u63a8\u5968\u3055\u308c\u308b\u5bfe\u7b56<\/strong><\/td><\/tr><tr><td><strong>ALDH2\u5909\u7570\u578b\uff08Lys\u578b\uff09<\/strong><\/td><td>\u7121\u7406\u306a\u98f2\u9152\u3092\u907f\u3051\u308b\u3001\u4f11\u809d\u65e5\u3092\u5897\u3084\u3059<\/td><\/tr><tr><td><strong>ADH1B\u9ad8\u6d3b\u6027\u578b<\/strong><\/td><td>\u98f2\u9152\u306e\u30b9\u30d4\u30fc\u30c9\u3092\u9045\u304f\u3057\u3001\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306e\u84c4\u7a4d\u3092\u6291\u3048\u308b<\/td><\/tr><tr><td><strong>DRD2 A1\u30a2\u30ec\u30eb\u4fdd\u6709<\/strong><\/td><td>\u4f9d\u5b58\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u305f\u3081\u3001\u9069\u91cf\u3092\u5b88\u308b\u30fb\u4ee3\u66ff\u7642\u6cd5\u3092\u691c\u8a0e<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3-2. \u533b\u7642\u6a5f\u95a2\u3067\u306e\u6d3b\u7528<\/strong><\/h3>\n\n\n\n<p>\u533b\u7642\u6a5f\u95a2\u3067\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u7d50\u679c\u3092\u3082\u3068\u306b\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u306e\u30ea\u30b9\u30af\u8a55\u4fa1\u3084\u6cbb\u7642\u65b9\u91dd\u3092\u6c7a\u5b9a\u3059\u308b\u52d5\u304d\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>**\u85ac\u7269\u7642\u6cd5\uff08\u30ca\u30eb\u30c8\u30ec\u30ad\u30bd\u30f3\u306a\u3069\uff09**\u306e\u9069\u5fdc\u5224\u65ad<\/li>\n\n\n\n<li>**\u884c\u52d5\u7642\u6cd5\uff08\u8a8d\u77e5\u884c\u52d5\u7642\u6cd5\uff09**\u3068\u306e\u7d44\u307f\u5408\u308f\u305b<\/li>\n\n\n\n<li><strong>\u5bb6\u65cf\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u8a55\u4fa1<\/strong><\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u3082\u3068\u306b\u500b\u5225\u5316\u533b\u7642\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u554f\u984c\u3078\u306e\u5bfe\u7b56\u304c\u3088\u308a\u52b9\u679c\u7684\u306b\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41593-019-0488-8\">\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u3068\u907a\u4f1d\u306e\u95a2\u4fc2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41591-020-0976-7\">\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u306e\u907a\u4f1d\u7684\u8981\u56e0<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6352387\/\">DRD2\u907a\u4f1d\u5b50\u3068\u98f2\u9152\u884c\u52d5<\/a><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>4. \u30a2\u30eb\u30b3\u30fc\u30eb\u611f\u53d7\u6027\u3068\u907a\u4f1d\u5b50\u306e\u8a73\u7d30\u306a\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"576\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/25991796_m-1024x576.jpg\" alt=\"\" class=\"wp-image-5141\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/25991796_m-1024x576.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/25991796_m-300x169.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/25991796_m-768x432.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/25991796_m-1536x864.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/25991796_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4-1. ALDH2\u907a\u4f1d\u5b50\u306e\u8a73\u7d30\u306a\u30e1\u30ab\u30cb\u30ba\u30e0<\/strong><\/h3>\n\n\n\n<p>ALDH2\u907a\u4f1d\u5b50\u306f\u3001\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306e\u5206\u89e3\u3092\u62c5\u3046\u91cd\u8981\u306a\u9175\u7d20\u306e\u4e00\u3064\u3067\u3059\u3002\u5909\u7570\u578b\uff08Lys\u578b\uff09\u3092\u6301\u3064\u4eba\u306f\u3001ALDH2\u306e\u6d3b\u6027\u304c\u5927\u304d\u304f\u4f4e\u4e0b\u3057\u3001\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306e\u5206\u89e3\u304c\u9045\u304f\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u8840\u4e2d\u306e\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u6fc3\u5ea6\u304c\u6025\u6fc0\u306b\u4e0a\u6607\u3057\u3001\u6b21\u306e\u3088\u3046\u306a\u75c7\u72b6\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u9854\u306e\u7d05\u6f6e\uff08\u30d5\u30e9\u30c3\u30b7\u30f3\u30b0\u53cd\u5fdc\uff09<\/li>\n\n\n\n<li>\u52d5\u60b8\u30fb\u5410\u304d\u6c17\u30fb\u3081\u307e\u3044<\/li>\n\n\n\n<li>\u982d\u75db\u30fb\u5026\u6020\u611f<\/li>\n\n\n\n<li>\u30a2\u30eb\u30b3\u30fc\u30eb\u6442\u53d6\u306b\u3088\u308b\u767a\u304c\u3093\u30ea\u30b9\u30af\u306e\u4e0a\u6607<\/li>\n<\/ul>\n\n\n\n<p>\u307e\u305f\u3001ALDH2\u306e\u6d3b\u6027\u304c\u4f4e\u3044\u4eba\u306f\u3001\u5c11\u91cf\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u3067\u3082\u5f37\u3044\u4e0d\u5feb\u611f\u3092\u611f\u3058\u308b\u305f\u3081\u3001\u81ea\u7136\u3068\u98f2\u9152\u91cf\u304c\u5236\u9650\u3055\u308c\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u306b\u306a\u308a\u306b\u304f\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4-2. ADH1B\u907a\u4f1d\u5b50\u3068\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u901f\u5ea6<\/strong><\/h3>\n\n\n\n<p>ADH1B\u907a\u4f1d\u5b50\u306f\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u3092\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306b\u5206\u89e3\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002ADH1B\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u3068\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u304c\u6025\u901f\u306b\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u3078\u3068\u5909\u63db\u3055\u308c\u308b\u305f\u3081\u3001\u30d5\u30e9\u30c3\u30b7\u30f3\u30b0\u53cd\u5fdc\u304c\u5f37\u304f\u306a\u308a\u3001\u98f2\u9152\u6642\u306e\u4e0d\u5feb\u611f\u304c\u5897\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>ADH1B\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u30d0\u30ea\u30a2\u30f3\u30c8<\/strong><\/td><td><strong>\u4ee3\u8b1d\u80fd\u529b<\/strong><\/td><td><strong>\u7279\u5fb4<\/strong><\/td><\/tr><tr><td>**ADH1B<em>1\/1<\/em><\/td><td>\u4f4e<\/td><td>\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u4ee3\u8b1d\u304c\u9045\u304f\u3001\u6bd4\u8f03\u7684\u9154\u3044\u306b\u304f\u3044<\/td><\/tr><tr><td>**ADH1B<em>1\/2<\/em><\/td><td>\u4e2d<\/td><td>\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306e\u84c4\u7a4d\u304c\u3084\u3084\u65e9\u304f\u3001\u98f2\u9152\u6642\u306b\u4e0d\u5feb\u611f\u3092\u611f\u3058\u308b\u3053\u3068\u304c\u3042\u308b<\/td><\/tr><tr><td>**ADH1B<em>2\/2<\/em><\/td><td>\u9ad8<\/td><td>\u4ee3\u8b1d\u304c\u975e\u5e38\u306b\u901f\u304f\u3001\u5f37\u3044\u30d5\u30e9\u30c3\u30b7\u30f3\u30b0\u53cd\u5fdc\u304c\u8d77\u3053\u308b<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>ADH1B*2\/*2\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u4ee3\u8b1d\u304c\u901f\u3059\u304e\u308b\u305f\u3081\u3001\u5c11\u91cf\u306e\u98f2\u9152\u3067\u3082\u4e0d\u5feb\u611f\u3092\u611f\u3058\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4-3. ALDH2\u30fbADH1B\u907a\u4f1d\u5b50\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308b\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<p>ALDH2\u3068ADH1B\u306e\u4e21\u65b9\u306e\u907a\u4f1d\u5b50\u304c\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u305d\u308c\u305e\u308c\u306e\u907a\u4f1d\u5b50\u578b\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u3063\u3066\u3001\u98f2\u9152\u5f8c\u306e\u53cd\u5fdc\u304c\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>ALDH2\u578b<\/strong><\/td><td><strong>ADH1B\u578b<\/strong><\/td><td><strong>\u30a2\u30eb\u30b3\u30fc\u30eb\u8010\u6027<\/strong><\/td><td><strong>\u7279\u5fb4<\/strong><\/td><\/tr><tr><td>\u6d3b\u6027\u578b\uff08Glu\u578b\uff09<\/td><td>\u4f4e\u6d3b\u6027\uff08*1\/*1\uff09<\/td><td>\u9ad8<\/td><td>\u98f2\u9152\u3092\u697d\u3057\u3081\u308b\u304c\u3001\u4f9d\u5b58\u30ea\u30b9\u30af\u304c\u9ad8\u3044<\/td><\/tr><tr><td>\u6d3b\u6027\u578b\uff08Glu\u578b\uff09<\/td><td>\u9ad8\u6d3b\u6027\uff08*2\/*2\uff09<\/td><td>\u4e2d<\/td><td>\u4ee3\u8b1d\u304c\u901f\u304f\u3001\u3059\u3050\u306b\u9154\u3044\u304c\u56de\u308b<\/td><\/tr><tr><td>\u4e0d\u6d3b\u6027\u578b\uff08Lys\u578b\uff09<\/td><td>\u4f4e\u6d3b\u6027\uff08*1\/*1\uff09<\/td><td>\u4f4e<\/td><td>\u5c11\u91cf\u306e\u98f2\u9152\u3067\u4f53\u8abf\u3092\u5d29\u3057\u3084\u3059\u3044<\/td><\/tr><tr><td>\u4e0d\u6d3b\u6027\u578b\uff08Lys\u578b\uff09<\/td><td>\u9ad8\u6d3b\u6027\uff08*2\/*2\uff09<\/td><td>\u6975\u3081\u3066\u4f4e<\/td><td>\u98f2\u9152\u6642\u306b\u5f37\u3044\u4e0d\u5feb\u611f\u304c\u3042\u308a\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u3092\u907f\u3051\u308b\u50be\u5411\u304c\u3042\u308b<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>ALDH2\u4e0d\u6d3b\u6027\u578b\uff08Lys\u578b\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u98f2\u9152\u306b\u3088\u308b\u5065\u5eb7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u305f\u3081\u3001\u9069\u5207\u306a\u7ba1\u7406\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>5. \u907a\u4f1d\u5b50\u3068\u30a2\u30eb\u30b3\u30fc\u30eb\u95a2\u9023\u75be\u60a3\u306e\u30ea\u30b9\u30af<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/22704232_m-1024x683.jpg\" alt=\"\u30de\u30c9\u30e9\u30fc\u30b9\u30d7\u30fc\u30f3\u3067\u6df7\u305c\u308b\u53f3\u624b\" class=\"wp-image-13794\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/22704232_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/22704232_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/22704232_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/22704232_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/22704232_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5-1. \u30a2\u30eb\u30b3\u30fc\u30eb\u3068\u767a\u304c\u3093\u30ea\u30b9\u30af<\/strong><\/h3>\n\n\n\n<p>ALDH2\u4e0d\u6d3b\u6027\u578b\u306e\u4eba\u306f\u3001\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u304c\u4f53\u5185\u306b\u9577\u304f\u7559\u307e\u308b\u305f\u3081\u3001\u304c\u3093\u306e\u30ea\u30b9\u30af\u304c\u4e0a\u6607\u3057\u307e\u3059\u3002\u7279\u306b\u3001<strong>\u98df\u9053\u304c\u3093<\/strong>\u3084<strong>\u809d\u81d3\u304c\u3093<\/strong>\u3068\u306e\u95a2\u9023\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u98f2\u9152\u306b\u3088\u308b\u304c\u3093\u30ea\u30b9\u30af\u306e\u5897\u52a0\uff08ALDH2\u306e\u5f71\u97ff\uff09<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ALDH2\u6d3b\u6027\u578b\uff08Glu\u578b\uff09<\/strong>\uff1a\u901a\u5e38\u306e\u30ea\u30b9\u30af<\/li>\n\n\n\n<li><strong>ALDH2\u90e8\u5206\u6d3b\u6027\u578b\uff08Glu\/Lys\u578b\uff09<\/strong>\uff1a\u98f2\u9152\u6642\u306b\u98df\u9053\u304c\u3093\u306e\u30ea\u30b9\u30af\u304c\u7d0410\u500d<\/li>\n\n\n\n<li><strong>ALDH2\u5b8c\u5168\u4e0d\u6d3b\u6027\u578b\uff08Lys\/Lys\u578b\uff09<\/strong>\uff1a\u98f2\u9152\u6642\u306b\u98df\u9053\u304c\u3093\u306e\u30ea\u30b9\u30af\u304c\u7d0450\u500d<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u30ea\u30b9\u30af\u3092\u8e0f\u307e\u3048\u3001ALDH2\u4e0d\u6d3b\u6027\u578b\u306e\u4eba\u306f\u904e\u5ea6\u306a\u98f2\u9152\u3092\u907f\u3051\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5-2. \u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u809d\u75be\u60a3\u3068\u907a\u4f1d<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u809d\u708e\u3084\u809d\u786c\u5909\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u9032\u884c\u30ea\u30b9\u30af\u304c\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PNPLA3\u907a\u4f1d\u5b50<\/strong>\uff1a\u809d\u81d3\u306e\u8102\u8cea\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3057\u3001\u5909\u7570\u578b\uff08I148M\uff09\u3092\u6301\u3064\u3068\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u809d\u306e\u30ea\u30b9\u30af\u304c\u4e0a\u6607\u3002<\/li>\n\n\n\n<li><strong>TM6SF2\u907a\u4f1d\u5b50<\/strong>\uff1a\u809d\u7d30\u80de\u306e\u8102\u80aa\u84c4\u7a4d\u3092\u8abf\u6574\u3057\u3001\u5909\u7570\u578b\u306f\u809d\u75be\u60a3\u306e\u9032\u884c\u3092\u52a0\u901f\u3055\u305b\u308b\u3002<\/li>\n\n\n\n<li><strong>ADH1C\u907a\u4f1d\u5b50<\/strong>\uff1a\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u4ee3\u8b1d\u80fd\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u5909\u7570\u578b\u306f\u809d\u6a5f\u80fd\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308a\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u95a2\u9023\u306e\u809d\u75be\u60a3\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3057\u3001\u4e88\u9632\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>6. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30eb\u30b3\u30fc\u30eb\u7ba1\u7406\u6226\u7565<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6-1. \u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u98f2\u9152\u7fd2\u6163\u306e\u6700\u9069\u5316<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u81ea\u5206\u306b\u9069\u3057\u305f\u98f2\u9152\u7fd2\u6163\u3092\u77e5\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50\u578b<\/strong><\/td><td><strong>\u63a8\u5968\u3055\u308c\u308b\u98f2\u9152\u5bfe\u7b56<\/strong><\/td><\/tr><tr><td><strong>ALDH2\u6d3b\u6027\u578b<\/strong><\/td><td>\u9069\u91cf\u3092\u5b88\u308a\u3001\u9031\u306b\u6570\u56de\u306e\u4f11\u809d\u65e5\u3092\u8a2d\u3051\u308b<\/td><\/tr><tr><td><strong>ALDH2\u4e0d\u6d3b\u6027\u578b<\/strong><\/td><td>\u30a2\u30eb\u30b3\u30fc\u30eb\u6442\u53d6\u3092\u63a7\u3048\u3081\u306b\u3057\u3001\u4ee3\u66ff\u98f2\u6599\u3092\u6d3b\u7528<\/td><\/tr><tr><td><strong>PNPLA3\u5909\u7570\u578b<\/strong><\/td><td>\u809d\u6a5f\u80fd\u691c\u67fb\u3092\u5b9a\u671f\u7684\u306b\u53d7\u3051\u3001\u98f2\u9152\u91cf\u3092\u8abf\u6574<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6-2. \u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u4e88\u9632\u306e\u305f\u3081\u306e\u907a\u4f1d\u5b50\u6d3b\u7528<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u907a\u4f1d\u5b50\u578b\uff08DRD2 A1\u30a2\u30ec\u30eb\u4fdd\u6709\u306a\u3069\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u98f2\u9152\u7fd2\u6163\u3092\u7ba1\u7406\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>\u5177\u4f53\u7684\u306a\u4e88\u9632\u7b56<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u3092\u5fb9\u5e95\u3057\u3001\u98f2\u9152\u4ee5\u5916\u306e\u30ea\u30e9\u30c3\u30af\u30b9\u65b9\u6cd5\u3092\u78ba\u7acb\u3059\u308b\u3002<\/li>\n\n\n\n<li>\u98f2\u9152\u91cf\u3092\u8a18\u9332\u3057\u3001\u4f9d\u5b58\u30ea\u30b9\u30af\u306e\u9ad8\u307e\u308a\u3092\u81ea\u899a\u3059\u308b\u3002<\/li>\n\n\n\n<li>\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u3001\u533b\u7642\u6a5f\u95a2\u3067\u306e\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3084\u6cbb\u7642\u3092\u53d7\u3051\u308b\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>7. \u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308b\u30a2\u30eb\u30b3\u30fc\u30eb\u30ea\u30b9\u30af\u7ba1\u7406\u306e\u5fdc\u7528<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/3346321_m-1024x683.jpg\" alt=\"\" class=\"wp-image-9210\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/3346321_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/3346321_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/3346321_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/3346321_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/3346321_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7-1. \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u7a2e\u985e\u3068\u7cbe\u5ea6<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u500b\u4eba\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u80fd\u529b\u3084\u4f9d\u5b58\u30ea\u30b9\u30af\u3092\u3088\u308a\u6b63\u78ba\u306b\u8a55\u4fa1\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u73fe\u5728\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u907a\u4f1d\u5b50\u691c\u67fb\u304c\u4e00\u822c\u306b\u63d0\u4f9b\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u4e3b\u306a\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u7a2e\u985e<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u691c\u67fb\u540d<\/strong><\/td><td><strong>\u5206\u6790\u5bfe\u8c61<\/strong><\/td><td><strong>\u76ee\u7684<\/strong><\/td><\/tr><tr><td><strong>ALDH2\u30fbADH1B\u907a\u4f1d\u5b50\u691c\u67fb<\/strong><\/td><td>\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u9175\u7d20<\/td><td>\u98f2\u9152\u8010\u6027\u306e\u8a55\u4fa1<\/td><\/tr><tr><td><strong>GABRA2\u30fbDRD2\u907a\u4f1d\u5b50\u691c\u67fb<\/strong><\/td><td>\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e\u53d7\u5bb9\u4f53<\/td><td>\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u30ea\u30b9\u30af\u8a55\u4fa1<\/td><\/tr><tr><td><strong>PNPLA3\u30fbTM6SF2\u907a\u4f1d\u5b50\u691c\u67fb<\/strong><\/td><td>\u809d\u81d3\u306e\u8102\u8cea\u4ee3\u8b1d<\/td><td>\u809d\u75be\u60a3\u30ea\u30b9\u30af\u306e\u8a55\u4fa1<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u553e\u6db2\u3084\u8840\u6db2\u3092\u7528\u3044\u3066\u7c21\u5358\u306b\u5b9f\u65bd\u3067\u304d\u308b\u3082\u306e\u304c\u591a\u304f\u3001\u7d50\u679c\u306f\u6570\u9031\u9593\u4ee5\u5185\u306b\u5f97\u3089\u308c\u308b\u3053\u3068\u304c\u4e00\u822c\u7684\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7-2. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u98f2\u9152\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u98f2\u9152\u306e\u63a8\u5968\u91cf\u3092\u8a2d\u5b9a\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u95a2\u9023\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u578b\u5225\u306e\u98f2\u9152\u63a8\u5968\u91cf<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50\u578b<\/strong><\/td><td><strong>\u63a8\u5968\u3055\u308c\u308b\u98f2\u9152\u91cf<\/strong><\/td><td><strong>\u7406\u7531<\/strong><\/td><\/tr><tr><td><strong>ALDH2\u6d3b\u6027\u578b\uff08Glu\/Glu\uff09<\/strong><\/td><td>1\u65e51\uff5e2\u676f\u307e\u3067<\/td><td>\u5206\u89e3\u80fd\u529b\u304c\u9ad8\u3044\u305f\u3081\u3001\u9069\u91cf\u306e\u98f2\u9152\u304c\u53ef\u80fd<\/td><\/tr><tr><td><strong>ALDH2\u90e8\u5206\u6d3b\u6027\u578b\uff08Glu\/Lys\uff09<\/strong><\/td><td>1\u9031\u9593\u306b1\uff5e2\u56de<\/td><td>\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u84c4\u7a4d\u306b\u3088\u308b\u30ea\u30b9\u30af\u304c\u4e2d\u7a0b\u5ea6<\/td><\/tr><tr><td><strong>ALDH2\u4e0d\u6d3b\u6027\u578b\uff08Lys\/Lys\uff09<\/strong><\/td><td>\u98f2\u9152\u975e\u63a8\u5968<\/td><td>\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u84c4\u7a4d\u306b\u3088\u308a\u5065\u5eb7\u30ea\u30b9\u30af\u304c\u9ad8\u3044<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306a\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u3005\u306b\u9069\u3057\u305f\u98f2\u9152\u7fd2\u6163\u3092\u78ba\u7acb\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7-3. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30eb\u30b3\u30fc\u30eb\u6559\u80b2\u306e\u5fc5\u8981\u6027<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30eb\u30b3\u30fc\u30eb\u6559\u80b2\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u82e5\u5e74\u5c64\u306e\u904e\u5270\u98f2\u9152\u3084\u4f9d\u5b58\u75c7\u306e\u4e88\u9632\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u304b\u3057\u305f\u6559\u80b2\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u4f8b<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u9ad8\u6821\u30fb\u5927\u5b66\u3067\u306e\u907a\u4f1d\u5b50\u578b\u306b\u57fa\u3065\u304f\u98f2\u9152\u30ea\u30b9\u30af\u6559\u80b2<\/li>\n\n\n\n<li>\u4f01\u696d\u306e\u5065\u5eb7\u7ba1\u7406\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u5c0e\u5165<\/li>\n\n\n\n<li>\u533b\u7642\u6a5f\u95a2\u3067\u306e\u500b\u5225\u6307\u5c0e\u306b\u3088\u308b\u98f2\u9152\u7fd2\u6163\u306e\u898b\u76f4\u3057<\/li>\n<\/ul>\n\n\n\n<p>\u7279\u306b\u3001\u65e5\u672c\u3067\u306fALDH2\u4e0d\u6d3b\u6027\u578b\u306e\u4eba\u304c\u591a\u3044\u305f\u3081\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3092\u7406\u89e3\u3057\u3001\u9069\u5207\u306a\u98f2\u9152\u7fd2\u6163\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>8. \u907a\u4f1d\u5b50\u3068\u30a2\u30eb\u30b3\u30fc\u30eb\u306b\u95a2\u9023\u3059\u308b\u85ac\u7406\u5b66\u7684\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8-1. \u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u6cbb\u7642\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u60c5\u5831\u306e\u6d3b\u7528<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u306e\u6cbb\u7642\u306b\u306f\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u6cbb\u7642\u304c\u6709\u52b9\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u578b\u5225\u306e\u6cbb\u7642\u6226\u7565<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50\u578b<\/strong><\/td><td><strong>\u63a8\u5968\u3055\u308c\u308b\u6cbb\u7642<\/strong><\/td><\/tr><tr><td><strong>DRD2 A1\u30a2\u30ec\u30eb\u4fdd\u6709<\/strong><\/td><td>\u30c9\u30fc\u30d1\u30df\u30f3\u53d7\u5bb9\u4f53\u3092\u6a19\u7684\u3068\u3059\u308b\u30ca\u30eb\u30c8\u30ec\u30ad\u30bd\u30f3\u3092\u4f7f\u7528<\/td><\/tr><tr><td><strong>GABRA2\u5909\u7570\u578b<\/strong><\/td><td>GABA\u53d7\u5bb9\u4f53\u306b\u4f5c\u7528\u3059\u308b\u30d0\u30af\u30ed\u30d5\u30a7\u30f3\u3092\u4f7f\u7528<\/td><\/tr><tr><td><strong>CYP2E1\u9ad8\u6d3b\u6027\u578b<\/strong><\/td><td>\u809d\u81d3\u3067\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u3092\u8abf\u6574\u3059\u308b\u85ac\u5264\u3092\u4f7f\u7528<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8-2. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u65b0\u3057\u3044\u6cbb\u7642\u85ac\u306e\u958b\u767a<\/strong><\/h3>\n\n\n\n<p>\u8fd1\u5e74\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u907a\u4f1d\u5b50\u3092\u6a19\u7684\u3068\u3059\u308b\u65b0\u85ac\u306e\u958b\u767a\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u958b\u767a\u4e2d\u306e\u907a\u4f1d\u5b50\u6a19\u7684\u85ac<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>DRD2\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac<\/strong>\uff1a\u30c9\u30fc\u30d1\u30df\u30f3\u306e\u904e\u5270\u6d3b\u6027\u3092\u6291\u3048\u3001\u98f2\u9152\u6b32\u6c42\u3092\u4f4e\u6e1b<\/li>\n\n\n\n<li><strong>GABRA2\u4fee\u98fe\u85ac<\/strong>\uff1a\u795e\u7d4c\u4f1d\u9054\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u8abf\u6574\u3057\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u98f2\u9152\u3092\u6291\u5236<\/li>\n\n\n\n<li><strong>ALDH2\u6d3b\u6027\u5316\u85ac<\/strong>\uff1aALDH2\u306e\u50cd\u304d\u3092\u88dc\u52a9\u3057\u3001\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306e\u5206\u89e3\u3092\u4fc3\u9032<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6cbb\u7642\u6cd5\u304c\u78ba\u7acb\u3059\u308c\u3070\u3001\u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u3088\u308a\u52b9\u679c\u7684\u306a\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>9. \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u502b\u7406\u7684\u30fb\u793e\u4f1a\u7684\u8ab2\u984c<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31854106_m-1024x683.jpg\" alt=\"1\u672c\u6307\u3092\u7acb\u3066\u308b\u7537\u6027\u306e\u533b\u8005\" class=\"wp-image-8385\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31854106_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31854106_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31854106_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31854106_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31854106_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9-1. \u907a\u4f1d\u5b50\u60c5\u5831\u306e\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u7ba1\u7406<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u306f\u500b\u4eba\u306e\u5065\u5eb7\u72b6\u614b\u3084\u4f53\u8cea\u3092\u53cd\u6620\u3059\u308b\u975e\u5e38\u306b\u30bb\u30f3\u30b7\u30c6\u30a3\u30d6\u306a\u30c7\u30fc\u30bf\u3067\u3042\u308b\u305f\u3081\u3001\u305d\u306e\u7ba1\u7406\u306b\u306f\u614e\u91cd\u3092\u671f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u4fdd\u8b77\u306e\u4e3b\u306a\u8ab2\u984c<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u60c5\u5831\u306e\u4e0d\u6b63\u5229\u7528\uff08\u751f\u547d\u4fdd\u967a\u52a0\u5165\u6642\u306e\u4e0d\u5229\u76ca\u306a\u3069\uff09<\/li>\n\n\n\n<li>\u30c7\u30fc\u30bf\u6f0f\u6d29\u306b\u3088\u308b\u500b\u4eba\u60c5\u5831\u306e\u6d41\u51fa<\/li>\n\n\n\n<li>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u7406\u7531\u3068\u3057\u305f\u793e\u4f1a\u7684\u5dee\u5225<\/li>\n<\/ul>\n\n\n\n<p>\u73fe\u5728\u3001\u591a\u304f\u306e\u56fd\u3067\u907a\u4f1d\u5b50\u60c5\u5831\u306e\u5229\u7528\u306b\u95a2\u3059\u308b\u898f\u5236\u304c\u9032\u3081\u3089\u308c\u3066\u304a\u308a\u3001\u65e5\u672c\u3067\u3082\u300c\u500b\u4eba\u60c5\u5831\u4fdd\u8b77\u6cd5\u300d\u306b\u57fa\u3065\u304d\u3001\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u306e\u53d6\u308a\u6271\u3044\u304c\u53b3\u683c\u306b\u7ba1\u7406\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9-2. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30eb\u30b3\u30fc\u30eb\u5bfe\u7b56\u306e\u793e\u4f1a\u7684\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30eb\u30b3\u30fc\u30eb\u5bfe\u7b56\u304c\u666e\u53ca\u3059\u308c\u3070\u3001\u500b\u4eba\u306e\u5065\u5eb7\u7ba1\u7406\u3060\u3051\u3067\u306a\u304f\u3001\u793e\u4f1a\u5168\u4f53\u306b\u591a\u304f\u306e\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u793e\u4f1a\u7684\u5f71\u97ff\u306e\u4f8b<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4f01\u696d\u306e\u5065\u5eb7\u8a3a\u65ad\u30d7\u30ed\u30b0\u30e9\u30e0\u3078\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u5c0e\u5165<\/li>\n\n\n\n<li>\u4fdd\u967a\u4f1a\u793e\u306b\u3088\u308b\u98f2\u9152\u30ea\u30b9\u30af\u8a55\u4fa1\u306e\u9ad8\u5ea6\u5316<\/li>\n\n\n\n<li>\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u306e\u65e9\u671f\u767a\u898b\u30fb\u4e88\u9632\u7b56\u306e\u5f37\u5316<\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u306e\u6d3b\u7528\u306f\u3001\u98f2\u9152\u7fd2\u6163\u306e\u9069\u6b63\u5316\u3084\u4f9d\u5b58\u75c7\u5bfe\u7b56\u306b\u5f79\u7acb\u3064\u4e00\u65b9\u3067\u3001\u9069\u5207\u306a\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>10. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30eb\u30b3\u30fc\u30eb\u30ea\u30b9\u30af\u7ba1\u7406\u306e\u672a\u6765<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10-1. AI\u3068\u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u305f\u30ea\u30b9\u30af\u4e88\u6e2c<\/strong><\/h3>\n\n\n\n<p>\u4eca\u5f8c\u3001\u4eba\u5de5\u77e5\u80fd\uff08AI\uff09\u3068\u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30eb\u30b3\u30fc\u30eb\u30ea\u30b9\u30af\u4e88\u6e2c\u30b7\u30b9\u30c6\u30e0\u304c\u767b\u5834\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>AI\u3092\u6d3b\u7528\u3057\u305f\u30ea\u30b9\u30af\u8a55\u4fa1\u306e\u4f8b<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3068\u751f\u6d3b\u7fd2\u6163\u306e\u76f8\u95a2\u5206\u6790<\/li>\n\n\n\n<li>\u500b\u5225\u306e\u98f2\u9152\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3057\u3001\u8b66\u544a\u3092\u767a\u3059\u308b\u30a2\u30d7\u30ea\u306e\u958b\u767a<\/li>\n\n\n\n<li>\u98f2\u9152\u306b\u3088\u308b\u5065\u5eb7\u5f71\u97ff\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10-2. \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306b\u3088\u308b\u30a2\u30eb\u30b3\u30fc\u30eb\u611f\u53d7\u6027\u306e\u8abf\u6574<\/strong><\/h3>\n\n\n\n<p>CRISPR-Cas9\u306a\u3069\u306e\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u304c\u767a\u5c55\u3059\u308c\u3070\u3001\u5c06\u6765\u7684\u306b\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u80fd\u529b\u3092\u8abf\u6574\u3059\u308b\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u7814\u7a76\u4e2d\u306e\u907a\u4f1d\u5b50\u7de8\u96c6\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ALDH2\u306e\u6d3b\u6027\u3092\u8abf\u6574\u3057\u3001\u98f2\u9152\u6642\u306e\u4e0d\u5feb\u611f\u3092\u8efd\u6e1b<\/li>\n\n\n\n<li>DRD2\u306e\u8abf\u6574\u306b\u3088\u308a\u3001\u4f9d\u5b58\u30ea\u30b9\u30af\u3092\u6291\u5236<\/li>\n\n\n\n<li>\u809d\u81d3\u306e\u4ee3\u8b1d\u6a5f\u80fd\u3092\u5f37\u5316\u3057\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u95a2\u9023\u75be\u60a3\u3092\u4e88\u9632<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6280\u8853\u304c\u78ba\u7acb\u3055\u308c\u308c\u3070\u3001\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u30ea\u30b9\u30af\u7ba1\u7406\u304c\u53ef\u80fd\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>11. \u907a\u4f1d\u5b50\u3068\u30a2\u30eb\u30b3\u30fc\u30eb\u8010\u6027\u306e\u9032\u5316\u7684\u80cc\u666f<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/31267628_m-1024x683.jpg\" alt=\"\" class=\"wp-image-9189\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31267628_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31267628_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31267628_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31267628_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31267628_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>11-1. \u306a\u305c\u6771\u30a2\u30b8\u30a2\u4eba\u306f\u30a2\u30eb\u30b3\u30fc\u30eb\u306b\u5f31\u3044\u306e\u304b\uff1f<\/strong><\/h3>\n\n\n\n<p>ALDH2\u306e\u4e0d\u6d3b\u6027\u578b\uff08Lys\u578b\uff09\u304c\u6771\u30a2\u30b8\u30a2\u306b\u591a\u3044\u7406\u7531\u306b\u3064\u3044\u3066\u306f\u3001\u9032\u5316\u7684\u306a\u9069\u5fdc\u306e\u89b3\u70b9\u304b\u3089\u3044\u304f\u3064\u304b\u306e\u4eee\u8aac\u304c\u63d0\u5531\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u9032\u5316\u7684\u8981\u56e0\u306e\u4eee\u8aac<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u75c5\u539f\u4f53\u9632\u5fa1\u8aac<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306e\u84c4\u7a4d\u304c\u5bc4\u751f\u866b\u3084\u7d30\u83cc\u306b\u5bfe\u3059\u308b\u9632\u5fa1\u6a5f\u80fd\u3092\u6301\u3064\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li>\u9ad8\u6e7f\u5ea6\u306e\u74b0\u5883\u3067\u306f\u75c5\u539f\u4f53\u304c\u7e41\u6b96\u3057\u3084\u3059\u3044\u305f\u3081\u3001ALDH2\u4e0d\u6d3b\u6027\u578b\u306e\u4eba\u304c\u751f\u5b58\u3057\u3084\u3059\u304b\u3063\u305f\u53ef\u80fd\u6027\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u7c73\u6587\u5316\u3068\u767a\u9175\u98df\u54c1\u8aac<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u6771\u30a2\u30b8\u30a2\u3067\u306f\u7a32\u4f5c\u304c\u76db\u3093\u3067\u3001\u98df\u6587\u5316\u3068\u3057\u3066\u767a\u9175\u98df\u54c1\u304c\u591a\u304b\u3063\u305f\u3002<\/li>\n\n\n\n<li>\u767a\u9175\u98df\u54c1\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u30a8\u30bf\u30ce\u30fc\u30eb\u3092\u4e00\u5b9a\u91cf\u53d6\u308a\u8fbc\u3080\u6a5f\u4f1a\u304c\u591a\u304f\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u306e\u591a\u69d8\u6027\u304c\u751f\u307e\u308c\u305f\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u793e\u4f1a\u7684\u30fb\u6587\u5316\u7684\u5f71\u97ff\u8aac<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30a2\u30eb\u30b3\u30fc\u30eb\u8010\u6027\u304c\u4f4e\u3044\u3053\u3068\u3067\u3001\u904e\u5ea6\u306a\u98f2\u9152\u304c\u6291\u5236\u3055\u308c\u3001\u793e\u4f1a\u7684\u306a\u79e9\u5e8f\u304c\u4fdd\u305f\u308c\u305f\u53ef\u80fd\u6027\u3002<\/li>\n\n\n\n<li>\u98f2\u9152\u304c\u5c11\u306a\u3044\u6587\u5316\u3067\u306f\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u95a2\u9023\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u304f\u3001\u907a\u4f1d\u5b50\u5909\u7570\u304c\u6dd8\u6c70\u3055\u308c\u306a\u304b\u3063\u305f\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>11-2. \u4e16\u754c\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u907a\u4f1d\u5b50\u306e\u5206\u5e03<\/strong><\/h3>\n\n\n\n<p>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u306f\u5730\u57df\u3054\u3068\u306b\u7570\u306a\u308b\u5206\u5e03\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>ALDH2\u4e0d\u6d3b\u6027\u578b\u306e\u5272\u5408<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u5730\u57df<\/strong><\/td><td><strong>\u4e0d\u6d3b\u6027\u578b\u306e\u5272\u5408<\/strong><\/td><\/tr><tr><td>\u65e5\u672c<\/td><td>\u7d0440%<\/td><\/tr><tr><td>\u4e2d\u56fd<\/td><td>\u7d0430-35%<\/td><\/tr><tr><td>\u97d3\u56fd<\/td><td>\u7d0430%<\/td><\/tr><tr><td>\u30a4\u30f3\u30c9<\/td><td>\u7d045-10%<\/td><\/tr><tr><td>\u30e8\u30fc\u30ed\u30c3\u30d1<\/td><td>\u307b\u307c0%<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u6771\u30a2\u30b8\u30a2\u306b\u96c6\u4e2d\u3057\u3066ALDH2\u306e\u4e0d\u6d3b\u6027\u578b\u304c\u5206\u5e03\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>12. \u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u3068\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12-1. \u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u306f\uff1f<\/strong><\/h3>\n\n\n\n<p>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u306f\u3001DNA\u306e\u5869\u57fa\u914d\u5217\u3092\u5909\u3048\u308b\u3053\u3068\u306a\u304f\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u6574\u3059\u308b\u4ed5\u7d44\u307f\u306e\u3053\u3068\u3092\u6307\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30a2\u30eb\u30b3\u30fc\u30eb\u6442\u53d6\u306b\u3088\u308b\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5909\u5316\u304c\u7814\u7a76\u3055\u308c\u3066\u304a\u308a\u3001\u7279\u306bDNA\u30e1\u30c1\u30eb\u5316\u3084\u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u304c\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12-2. \u30a2\u30eb\u30b3\u30fc\u30eb\u6442\u53d6\u3068DNA\u30e1\u30c1\u30eb\u5316<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9577\u671f\u9593\u306e\u98f2\u9152<\/strong>\u306f\u3001ALDH2\u3084ADH1B\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u306e\u30e1\u30c1\u30eb\u5316\u3092\u5909\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>DNA\u30e1\u30c1\u30eb\u5316\u306e\u5909\u5316<\/strong>\u306b\u3088\u308a\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u9175\u7d20\u306e\u767a\u73fe\u91cf\u304c\u5909\u308f\u308a\u3001\u98f2\u9152\u7fd2\u6163\u304c\u5909\u52d5\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u4f9d\u5b58\u75c7\u306e\u767a\u75c7<\/strong>\u3068\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\uff08\u4f8b\uff1aBDNF\u907a\u4f1d\u5b50\uff09\u306e\u30e1\u30c1\u30eb\u5316\u30ec\u30d9\u30eb\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12-3. \u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u3068\u30a2\u30eb\u30b3\u30fc\u30eb\u8010\u6027<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d2\u30b9\u30c8\u30f3\u30a2\u30bb\u30c1\u30eb\u5316<\/strong>\u304cADH1B\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3057\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u80fd\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u53ef\u80fd\u6027\u3002<\/li>\n\n\n\n<li>**\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\uff08HDAC\uff09**\u306e\u6d3b\u6027\u304c\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u306e\u30ea\u30b9\u30af\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u7814\u7a76\u306f\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u304c\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3060\u3051\u3067\u306a\u304f\u3001\u74b0\u5883\u8981\u56e0\u3084\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306b\u3088\u3063\u3066\u3082\u5909\u5316\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>13. \u907a\u4f1d\u5b50\u578b\u3068\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u81d3\u5668<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"576\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/28381101_m-1024x576.jpg\" alt=\"\" class=\"wp-image-9224\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/28381101_m-1024x576.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/28381101_m-300x169.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/28381101_m-768x432.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/28381101_m-1536x864.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/28381101_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>13-1. \u809d\u81d3\u306e\u907a\u4f1d\u5b50\u578b\u3068\u30a2\u30eb\u30b3\u30fc\u30eb\u611f\u53d7\u6027<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30eb\u30b3\u30fc\u30eb\u306f\u809d\u81d3\u3067\u4e3b\u306b\u4ee3\u8b1d\u3055\u308c\u308b\u305f\u3081\u3001\u809d\u6a5f\u80fd\u306e\u907a\u4f1d\u7684\u306a\u9055\u3044\u304c\u30a2\u30eb\u30b3\u30fc\u30eb\u95a2\u9023\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u6c7a\u5b9a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u809d\u75be\u60a3\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u95a2\u4e0e\u3059\u308b\u75be\u60a3<\/strong><\/td><td><strong>\u5f71\u97ff<\/strong><\/td><\/tr><tr><td><strong>PNPLA3<\/strong><\/td><td>\u8102\u80aa\u809d\u3001\u809d\u786c\u5909<\/td><td>\u5909\u7570\u578b\uff08I148M\uff09\u3092\u6301\u3064\u3068\u8102\u80aa\u84c4\u7a4d\u304c\u5897\u52a0<\/td><\/tr><tr><td><strong>TM6SF2<\/strong><\/td><td>\u809d\u7dda\u7dad\u5316\u3001\u809d\u304c\u3093<\/td><td>\u5909\u7570\u578b\u306f\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u809d\u75be\u60a3\u306e\u9032\u884c\u3092\u52a0\u901f<\/td><\/tr><tr><td><strong>HSD17B13<\/strong><\/td><td>\u809d\u4fdd\u8b77\u4f5c\u7528<\/td><td>\u5909\u7570\u578b\u306f\u809d\u786c\u5909\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u3063\u3066\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u306b\u3088\u308b\u809d\u81d3\u3078\u306e\u5f71\u97ff\u3092\u4e8b\u524d\u306b\u77e5\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u305f\u3081\u3001\u751f\u6d3b\u7fd2\u6163\u306e\u898b\u76f4\u3057\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>13-2. \u8133\u3068\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30eb\u30b3\u30fc\u30eb\u306f\u795e\u7d4c\u7cfb\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u907a\u4f1d\u5b50\u578b\u306b\u3088\u3063\u3066\u8133\u306e\u53cd\u5fdc\u304c\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u795e\u7d4c\u7cfb\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>BDNF\u907a\u4f1d\u5b50<\/strong>\uff1a\u795e\u7d4c\u7d30\u80de\u306e\u6210\u9577\u306b\u95a2\u4e0e\u3057\u3001\u5909\u7570\u578b\u306f\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u306e\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u3002<\/li>\n\n\n\n<li><strong>GABRA2\u907a\u4f1d\u5b50<\/strong>\uff1aGABA\u53d7\u5bb9\u4f53\u306e\u8abf\u6574\u3092\u884c\u3044\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u93ae\u9759\u52b9\u679c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3002<\/li>\n\n\n\n<li><strong>CHRM2\u907a\u4f1d\u5b50<\/strong>\uff1a\u8a8d\u77e5\u6a5f\u80fd\u3068\u95a2\u4fc2\u304c\u3042\u308a\u3001\u9577\u671f\u306e\u98f2\u9152\u306b\u3088\u308b\u8a18\u61b6\u529b\u4f4e\u4e0b\u306b\u5f71\u97ff\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u5f71\u97ff\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u308b\u305f\u3081\u306e\u500b\u5225\u5316\u3055\u308c\u305f\u5bfe\u7b56\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>14. \u907a\u4f1d\u5b50\u691c\u67fb\u3068\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30fb\u30cb\u30e5\u30fc\u30c8\u30ea\u30b7\u30e7\u30f3<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>14-1. \u6804\u990a\u5b66\u3068\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u4ee3\u8b1d\u306b\u306f\u3001\u30d3\u30bf\u30df\u30f3\u3084\u30df\u30cd\u30e9\u30eb\u306e\u6442\u53d6\u304c\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u6804\u990a\u7d20<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d3\u30bf\u30df\u30f3B1\uff08\u30c1\u30a2\u30df\u30f3\uff09<\/strong>\uff1a\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u795e\u7d4c\u969c\u5bb3\u3092\u4e88\u9632<\/li>\n\n\n\n<li><strong>\u30ca\u30a4\u30a2\u30b7\u30f3\uff08\u30d3\u30bf\u30df\u30f3B3\uff09<\/strong>\uff1aADH\u3068ALDH\u306e\u6d3b\u6027\u3092\u30b5\u30dd\u30fc\u30c8<\/li>\n\n\n\n<li><strong>\u4e9c\u925b<\/strong>\uff1a\u809d\u81d3\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u306b\u95a2\u4e0e<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>14-2. \u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u6804\u990a\u7ba1\u7406<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u9069\u5207\u306a\u6804\u990a\u6442\u53d6\u306b\u3088\u308b\u30a2\u30eb\u30b3\u30fc\u30eb\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u578b\u5225\u306e\u6804\u990a\u7ba1\u7406\u4f8b<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50\u578b<\/strong><\/td><td><strong>\u63a8\u5968\u6804\u990a\u7d20<\/strong><\/td><\/tr><tr><td><strong>ALDH2\u4e0d\u6d3b\u6027\u578b<\/strong><\/td><td>\u30d3\u30bf\u30df\u30f3B\u7fa4\u3001\u6297\u9178\u5316\u7269\u8cea<\/td><\/tr><tr><td><strong>PNPLA3\u5909\u7570\u578b<\/strong><\/td><td>\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3001\u4f4e\u8102\u80aa\u98df<\/td><\/tr><tr><td><strong>BDNF\u5909\u7570\u578b<\/strong><\/td><td>\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u3001\u6297\u708e\u75c7\u98df\u54c1<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u6804\u990a\u5b66\u3068\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u306b\u3088\u308b\u5065\u5eb7\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>15. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30eb\u30b3\u30fc\u30eb\u5bfe\u7b56\u306e\u672a\u6765<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/32071133_m-1024x683.jpg\" alt=\"\" class=\"wp-image-9203\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/32071133_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/32071133_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/32071133_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/32071133_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/32071133_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>15-1. \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u4e88\u9632\u533b\u7642\u306e\u9032\u5316<\/strong><\/h3>\n\n\n\n<p>\u4eca\u5f8c\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u666e\u53ca\u306b\u3088\u308a\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u95a2\u9023\u75be\u60a3\u306e\u4e88\u9632\u533b\u7642\u304c\u3055\u3089\u306b\u9032\u5316\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001<strong>\u500b\u4eba\u306e\u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u98f2\u9152\u30ea\u30b9\u30af\u8a55\u4fa1<\/strong>\u3092\u884c\u3044\u3001\u75c5\u9662\u3084\u30af\u30ea\u30cb\u30c3\u30af\u3067\u306e\u5065\u5eb7\u8a3a\u65ad\u306b\u7d44\u307f\u8fbc\u3080\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u533b\u7642<\/strong>\u306e\u4e00\u74b0\u3068\u3057\u3066\u3001\u98f2\u9152\u306b\u4f34\u3046\u809d\u81d3\u306e\u8ca0\u62c5\u3084\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u306e\u30ea\u30b9\u30af\u3092\u4e8b\u524d\u306b\u77e5\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u9069\u5207\u306a\u5065\u5eb7\u7ba1\u7406\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>15-2. \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306b\u3088\u308b\u30a2\u30eb\u30b3\u30fc\u30eb\u8010\u6027\u306e\u8abf\u6574<\/strong><\/h3>\n\n\n\n<p>CRISPR-Cas9\u306a\u3069\u306e\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3092\u5229\u7528\u3057\u3001\u5c06\u6765\u7684\u306b\u306f<strong>ALDH2\u306e\u6a5f\u80fd\u3092\u56de\u5fa9\u3055\u305b\u308b\u6cbb\u7642\u6cd5<\/strong>\u304c\u958b\u767a\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001ALDH2\u4e0d\u6d3b\u6027\u578b\u306e\u4eba\u3082\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306e\u84c4\u7a4d\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u98f2\u9152\u6642\u306e\u5065\u5eb7\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3067\u304d\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>15-3. \u30c7\u30b8\u30bf\u30eb\u30d8\u30eb\u30b9\u3068\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u306e\u7d71\u5408<\/strong><\/h3>\n\n\n\n<p>\u30b9\u30de\u30fc\u30c8\u30d5\u30a9\u30f3\u30a2\u30d7\u30ea\u3084\u30a6\u30a7\u30a2\u30e9\u30d6\u30eb\u30c7\u30d0\u30a4\u30b9\u3068\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3057\u3001\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u306e\u72b6\u614b\u3092\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3059\u308b\u6280\u8853\u3082\u767b\u5834\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001<strong>\u8840\u4e2d\u30a2\u30eb\u30b3\u30fc\u30eb\u6fc3\u5ea6\u3084\u4ee3\u8b1d\u901f\u5ea6\u3092AI\u304c\u5206\u6790\u3057\u3001\u9069\u5207\u306a\u98f2\u9152\u91cf\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u63d0\u6848\u3059\u308b<\/strong>\u3088\u3046\u306a\u30b7\u30b9\u30c6\u30e0\u304c\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6280\u8853\u9769\u65b0\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30eb\u30b3\u30fc\u30eb\u30ea\u30b9\u30af\u7ba1\u7406\u304c\u3055\u3089\u306b\u9032\u5316\u3057\u3001\u500b\u3005\u306b\u6700\u9069\u306a\u5065\u5eb7\u7ba1\u7406\u304c\u53ef\u80fd\u306b\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u307e\u3068\u3081<\/strong><\/h2>\n\n\n\n<p>\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u8010\u6027\u3084\u4f9d\u5b58\u30ea\u30b9\u30af\u306f\u3001\u4e3b\u306b<strong>ALDH2<\/strong>\u3084<strong>ADH1B<\/strong>\u3068\u3044\u3063\u305f\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u6c7a\u307e\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u578b\u3092\u77e5\u308b\u3053\u3068\u3067\u3001\u81ea\u5206\u306b\u9069\u3057\u305f\u98f2\u9152\u7fd2\u6163\u3092\u78ba\u7acb\u3057\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u95a2\u9023\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u767a\u5c55\u306b\u3088\u308a\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u98f2\u9152\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3084\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u306e\u4e88\u9632\u304c\u73fe\u5b9f\u306e\u3082\u306e\u3068\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u3001<strong>AI\u6280\u8853\u3084\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853<\/strong>\u306e\u9032\u5316\u306b\u3088\u3063\u3066\u3001\u5c06\u6765\u7684\u306b\u306f\u30a2\u30eb\u30b3\u30fc\u30eb\u306b\u3088\u308b\u5065\u5eb7\u30ea\u30b9\u30af\u3092\u3088\u308a\u52b9\u679c\u7684\u306b\u7ba1\u7406\u3067\u304d\u308b\u6642\u4ee3\u304c\u8a2a\u308c\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u306f\u3058\u3081\u306b \u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u6442\u53d6\u306b\u5bfe\u3059\u308b\u4f53\u306e\u53cd\u5fdc\u306f\u4eba\u305d\u308c\u305e\u308c\u7570\u306a\u308a\u307e\u3059\u3002\u3042\u308b\u4eba\u306f\u5c11\u91cf\u306e\u9152\u3067\u3082\u9854\u304c\u8d64\u304f\u306a\u308a\u3001\u3059\u3050\u306b\u9154\u3063\u3066\u3057\u307e\u3046\u4e00\u65b9\u3067\u3001\u5225\u306e\u4eba\u306f\u5927\u91cf\u306b\u98f2\u3093\u3067\u3082\u5e73\u7136\u3068\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u9055\u3044\u306e\u80cc\u666f\u306b\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u6df1\u304f\u95a2\u4e0e\u3057 [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":13787,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6],"tags":[],"class_list":["post-448","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-basicknowledge"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/448","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=448"}],"version-history":[{"count":4,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/448\/revisions"}],"predecessor-version":[{"id":13801,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/448\/revisions\/13801"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/13787"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=448"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=448"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=448"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}