{"id":459,"date":"2024-11-14T01:02:34","date_gmt":"2024-11-14T01:02:34","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=459"},"modified":"2025-04-09T03:03:11","modified_gmt":"2025-04-09T03:03:11","slug":"diabetes-risk-genetic-testing-prevention","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/diabetes-risk-genetic-testing-prevention\/","title":{"rendered":"\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u898b\u308b\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3068\u4e88\u9632\u6cd5"},"content":{"rendered":"\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>1. \u7cd6\u5c3f\u75c5\u3068\u907a\u4f1d\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u306f\u3001\u8840\u7cd6\u5024\u306e\u8abf\u7bc0\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u6162\u6027\u75be\u60a3\u3067\u3042\u308a\u3001\u4e3b\u306b1\u578b\u7cd6\u5c3f\u75c5\u30682\u578b\u7cd6\u5c3f\u75c5\u306b\u5206\u985e\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u767a\u75c7\u306b\u306f\u3001\u751f\u6d3b\u7fd2\u6163\u3060\u3051\u3067\u306a\u304f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3082\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u6280\u8853\u304c\u9032\u6b69\u3057\u3001\u500b\u4eba\u306e\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u4e8b\u524d\u306b\u628a\u63e1\u3057\u3001\u4e88\u9632\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u306b\u95a2\u4fc2\u3059\u308b\u907a\u4f1d\u5b50\u591a\u578b\u306f100\u7a2e\u985e\u4ee5\u4e0a\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u7279\u306b2\u578b\u7cd6\u5c3f\u75c5\u3067\u306f\u907a\u4f1d\u8981\u56e0\u306e\u5f71\u97ff\u304c\u5927\u304d\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17909091\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. 2\u578b\u7cd6\u5c3f\u75c5\u306b\u95a2\u308f\u308b\u4e3b\u306a\u907a\u4f1d\u5b50<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) TCF7L2\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>TCF7L2\uff08Transcription Factor 7-Like 2\uff09\u907a\u4f1d\u5b50\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3068\u8840\u7cd6\u5024\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3001\u7cd6\u5c3f\u75c5\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u6700\u3082\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u306e\u4e00\u3064\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs7903146\u306eT\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306e\u4f4e\u4e0b<\/li>\n\n\n\n<li>\u8840\u7cd6\u5024\u306e\u4e0a\u6607<\/li>\n\n\n\n<li>\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u304c1.4\uff5e1.8\u500d\u4e0a\u6607<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u6b27\u7c73\u4eba\u3001\u30a2\u30b8\u30a2\u4eba\u3001\u30a2\u30d5\u30ea\u30ab\u4eba\u306e\u96c6\u56e3\u306b\u304a\u3044\u3066\u3001TCF7L2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c2\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u306b\u5927\u304d\u304f\u5f71\u97ff\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17003356\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) KCNJ11\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>KCNJ11\uff08\u30ab\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u907a\u4f1d\u5b50\uff09\u306f\u3001\u81b5\u81d3\u306e\u03b2\u7d30\u80de\u3067\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u8abf\u7bc0\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs5219\u306eE23K\u591a\u578b\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u7cd6\u5c3f\u75c5\u767a\u75c7\u30ea\u30b9\u30af\u304c\u7d041.2\uff5e1.5\u500d\u4e0a\u6607<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u7279\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u98df\u4e8b\u3084\u904b\u52d5\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15126564\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(3) FTO\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>FTO\uff08\u8102\u80aa\u8cea\u95a2\u9023\u907a\u4f1d\u5b50\uff09\u306f\u3001\u98df\u6b32\u8abf\u7bc0\u3084\u8102\u80aa\u4ee3\u8b1d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u3067\u3001\u9593\u63a5\u7684\u306b\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs9939609\u306eA\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>BMI\u306e\u4e0a\u6607<\/li>\n\n\n\n<li>\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u5897\u52a0<\/li>\n\n\n\n<li>\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u304c1.2\uff5e1.6\u500d\u4e0a\u6607<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u7279\u306b\u9ad8\u8102\u80aa\u30fb\u9ad8\u30ab\u30ed\u30ea\u30fc\u98df\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u305f\u3081\u3001\u98df\u4e8b\u7ba1\u7406\u304c\u91cd\u8981\u3068\u306a\u308a\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17658951\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u7cd6\u5c3f\u75c5\u4e88\u9632\u6cd5<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"724\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/2469831_m-1024x724.jpg\" alt=\"\" class=\"wp-image-5113\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/2469831_m-1024x724.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/2469831_m-300x212.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/2469831_m-768x543.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/2469831_m-1536x1086.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/2469831_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) \u98df\u4e8b\u306e\u6700\u9069\u5316<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u3001\u7cd6\u8cea\u3084\u8102\u8cea\u306e\u4ee3\u8b1d\u80fd\u529b\u304c\u7570\u306a\u308b\u305f\u3081\u3001\u9069\u5207\u306a\u6804\u990a\u6226\u7565\u3092\u53d6\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>TCF7L2\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u4f4eGI\u98df\u54c1\u3092\u4e2d\u5fc3\u306b\u98df\u4e8b\u3092\u69cb\u6210<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u767d\u7c73\u3084\u30d1\u30f3\u306e\u4ee3\u308f\u308a\u306b\u3001\u7384\u7c73\u3084\u5168\u7c92\u7c89\u88fd\u54c1\u3092\u9078\u629e<\/li>\n\n\n\n<li>\u7cd6\u8cea\u306e\u6442\u53d6\u91cf\u3092\u9069\u5ea6\u306b\u7ba1\u7406<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>FTO\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u8102\u8cea\u306e\u6442\u53d6\u3092\u6291\u3048\u3001\u98df\u6b32\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4e0d\u98fd\u548c\u8102\u80aa\u9178\uff08\u9b5a\u3001\u30ca\u30c3\u30c4\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6<\/li>\n\n\n\n<li>\u98df\u4e8b\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3092\u898f\u5247\u7684\u306b\u3057\u3001\u9593\u98df\u3092\u6e1b\u3089\u3059<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) \u904b\u52d5\u306e\u5de5\u592b<\/strong><\/h3>\n\n\n\n<p>\u904b\u52d5\u306f\u7cd6\u5c3f\u75c5\u306e\u4e88\u9632\u30fb\u6539\u5584\u306b\u975e\u5e38\u306b\u6709\u52b9\u3067\u3059\u304c\u3001\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u6700\u9069\u306a\u904b\u52d5\u306e\u7a2e\u985e\u304c\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>KCNJ11\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u9ad8\u3081\u308b\u6709\u9178\u7d20\u904b\u52d5<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u9031\u306b150\u5206\u4ee5\u4e0a\u306e\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0\u3084\u30b8\u30e7\u30ae\u30f3\u30b0\u3092\u5b9f\u65bd<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>FTO\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u53d6\u308a\u5165\u308c\u308b<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7b4b\u8089\u91cf\u3092\u5897\u3084\u3059\u3053\u3068\u3067\u57fa\u790e\u4ee3\u8b1d\u3092\u5411\u4e0a\u3057\u3001\u8102\u80aa\u306e\u84c4\u7a4d\u3092\u9632\u3050<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(3) \u751f\u6d3b\u7fd2\u6163\u306e\u898b\u76f4\u3057<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u7d50\u679c\u306b\u57fa\u3065\u3044\u3066\u3001\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u3084\u7761\u7720\u7fd2\u6163\u306e\u6539\u5584\u3092\u884c\u3046\u3053\u3068\u3082\u7cd6\u5c3f\u75c5\u4e88\u9632\u306b\u6709\u52b9\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7761\u7720\u4e0d\u8db3\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u60aa\u5316\u3055\u305b\u308b\u305f\u3081\u30017\uff5e8\u6642\u9593\u306e\u7761\u7720\u3092\u78ba\u4fdd<\/strong><\/li>\n\n\n\n<li><strong>\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\uff08\u30de\u30a4\u30f3\u30c9\u30d5\u30eb\u30cd\u30b9\u3001\u30e8\u30ac\u306a\u3069\uff09\u3092\u53d6\u308a\u5165\u308c\u3001\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306e\u904e\u5270\u5206\u6ccc\u3092\u9632\u3050<\/strong><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>4. \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u9650\u754c\u3068\u6d3b\u7528\u306e\u6ce8\u610f\u70b9<\/strong><\/h2>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3059\u308b\u6709\u529b\u306a\u624b\u6bb5\u3067\u3059\u304c\u3001100%\u306e\u78ba\u5b9f\u6027\u304c\u3042\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) \u74b0\u5883\u8981\u56e0\u3068\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306f\u3042\u304f\u307e\u3067\u300c\u30ea\u30b9\u30af\u300d\u3092\u793a\u3059\u3082\u306e\u3067\u3042\u308a\u3001\u751f\u6d3b\u7fd2\u6163\u304c\u5927\u304d\u304f\u5f71\u97ff\u3057\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u3044\u907a\u4f1d\u5b50\u3092\u6301\u3063\u3066\u3044\u3066\u3082\u3001\u4e0d\u5065\u5eb7\u306a\u751f\u6d3b\u3092\u7d9a\u3051\u308c\u3070\u767a\u75c7\u30ea\u30b9\u30af\u306f\u9ad8\u307e\u308a\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25277300\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) \u6c11\u65cf\u5dee\u306e\u8003\u616e<\/strong><\/h3>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u5f71\u97ff\u306f\u3001\u6c11\u65cf\u3054\u3068\u306b\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u6b27\u7c73\u4eba\u306b\u304a\u3044\u3066\u5f37\u3044\u95a2\u9023\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u907a\u4f1d\u5b50\u3067\u3082\u3001\u30a2\u30b8\u30a2\u4eba\u3067\u306f\u7570\u306a\u308b\u5f71\u97ff\u3092\u6301\u3064\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u7d50\u679c\u3092\u89e3\u91c8\u3059\u308b\u969b\u306b\u306f\u3001\u6700\u65b0\u306e\u7814\u7a76\u30c7\u30fc\u30bf\u3092\u8003\u616e\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(3) \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u6d3b\u7528\u6cd5<\/strong><\/h3>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u77e5\u308b\u3053\u3068\u306f\u3001\u3042\u304f\u307e\u3067\u4e88\u9632\u7b56\u306e\u4e00\u74b0\u3067\u3042\u308a\u3001\u904e\u5ea6\u306b\u4e0d\u5b89\u3092\u62b1\u304f\u5fc5\u8981\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3080\u3057\u308d\u3001\u9069\u5207\u306a\u98df\u4e8b\u30fb\u904b\u52d5\u30fb\u751f\u6d3b\u7fd2\u6163\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u3001\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3067\u304d\u308b\u3068\u3044\u3046\u30dd\u30b8\u30c6\u30a3\u30d6\u306a\u8996\u70b9\u3092\u6301\u3064\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>5. \u907a\u4f1d\u5b50\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"681\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/4623532_m-1024x681.jpg\" alt=\"\" class=\"wp-image-8861\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4623532_m-1024x681.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4623532_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4623532_m-768x511.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4623532_m-1536x1022.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4623532_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u7406\u89e3\u3059\u308b\u4e0a\u3067\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306e\u500b\u4eba\u5dee\u3082\u91cd\u8981\u3067\u3059\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3068\u306f\u3001\u7d30\u80de\u304c\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3069\u308c\u3060\u3051\u53cd\u5fdc\u3057\u3001\u8840\u7cd6\u3092\u51e6\u7406\u3059\u308b\u304b\u3092\u793a\u3059\u6307\u6a19\u3067\u3059\u3002\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u308a\u3001\u3053\u306e\u611f\u53d7\u6027\u304c\u7570\u306a\u308a\u3001\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) IRS1\u907a\u4f1d\u5b50\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u30b7\u30b0\u30ca\u30eb<\/strong><\/h3>\n\n\n\n<p>IRS1\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u53d7\u5bb9\u4f53\u57fa\u8cea1\uff09\u907a\u4f1d\u5b50\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u95a2\u4e0e\u3057\u3001\u8840\u7cd6\u306e\u53d6\u308a\u8fbc\u307f\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs2943641\u306eT\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306e\u4f4e\u4e0b<\/li>\n\n\n\n<li>\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u30ea\u30b9\u30af\u5897\u52a0<\/li>\n\n\n\n<li>\u7cd6\u5c3f\u75c5\u767a\u75c7\u30ea\u30b9\u30af\u304c\u7d041.2\u500d\u4e0a\u6607<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u7279\u306b\u7cd6\u8cea\u6442\u53d6\u306b\u6ce8\u610f\u3057\u3001\u98df\u5f8c\u306e\u8840\u7cd6\u4e0a\u6607\u3092\u6291\u3048\u308b\u98df\u7fd2\u6163\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20628086\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) PPARG\u907a\u4f1d\u5b50\u3068\u8102\u80aa\u7d30\u80de\u306e\u50cd\u304d<\/strong><\/h3>\n\n\n\n<p>PPARG\uff08\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u30ac\u30f3\u30de\uff09\u907a\u4f1d\u5b50\u306f\u3001\u8102\u80aa\u7d30\u80de\u306e\u5206\u5316\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u8abf\u7bc0\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs1801282\u306ePro12Ala\u5909\u7570\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u5897\u52a0<\/li>\n\n\n\n<li>\u8840\u7cd6\u8abf\u7bc0\u304c\u60aa\u5316\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u80a5\u6e80\u30ea\u30b9\u30af\u304c\u4e0a\u6607<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>PPARG\u306e\u7279\u5b9a\u306e\u5909\u7570\u306f\u3001\u98df\u4e8b\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u304f\u3001\u9ad8\u8102\u80aa\u98df\u3092\u907f\u3051\u308b\u3053\u3068\u3067\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3067\u304d\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14747225\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>6. \u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3068\u8178\u5185\u7d30\u83cc\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-1024x683.jpg\" alt=\"\" class=\"wp-image-8852\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8fd1\u5e74\u3001\u8178\u5185\u7d30\u83cc\u3068\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u306e\u95a2\u9023\u6027\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8178\u5185\u7d30\u83cc\u53e2\u306f\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u3082\u5f71\u97ff\u3092\u53d7\u3051\u3001\u7279\u5b9a\u306e\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) TLR4\u907a\u4f1d\u5b50\u3068\u8178\u5185\u708e\u75c7<\/strong><\/h3>\n\n\n\n<p>TLR4\uff08\u30c8\u30fc\u30eb\u69d8\u53d7\u5bb9\u4f534\uff09\u907a\u4f1d\u5b50\u306f\u3001\u8178\u5185\u306e\u514d\u75ab\u5fdc\u7b54\u3092\u8abf\u7bc0\u3057\u3001\u708e\u75c7\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs4986790\u306eA\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u8178\u5185\u306e\u708e\u75c7\u304c\u4fc3\u9032\u3055\u308c\u308b<\/li>\n\n\n\n<li>\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u9ad8\u307e\u308a\u3001\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u5897\u52a0<\/li>\n\n\n\n<li>\u7279\u5b9a\u306e\u8178\u5185\u7d30\u83cc\uff08\u30d0\u30af\u30c6\u30ed\u30a4\u30c7\u30b9\u5c5e\uff09\u306e\u6e1b\u5c11<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u767a\u9175\u98df\u54c1\u3084\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u8178\u5185\u74b0\u5883\u3092\u6539\u5584\u3057\u3001\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18604270\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) FUT2\u907a\u4f1d\u5b50\u3068\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027<\/strong><\/h3>\n\n\n\n<p>FUT2\uff08\u30d5\u30b3\u30b7\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc2\uff09\u907a\u4f1d\u5b50\u306f\u3001\u8178\u5185\u7d30\u83cc\u306e\u69cb\u6210\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3068\u95a2\u9023\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs601338\u306eG\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u708e\u75c7\u30de\u30fc\u30ab\u30fc\u306e\u4e0a\u6607<\/li>\n\n\n\n<li>\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u5897\u52a0<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u98df\u7269\u7e4a\u7dad\u3092\u591a\u304f\u542b\u3080\u98df\u4e8b\u3092\u610f\u8b58\u3057\u3001\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21979192\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>7. \u7cd6\u5c3f\u75c5\u3068\u907a\u4f1d\u5b50\u306b\u3088\u308b\u85ac\u7269\u6cbb\u7642\u306e\u500b\u5225\u5316<\/strong><\/h2>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u306e\u6cbb\u7642\u306b\u4f7f\u7528\u3055\u308c\u308b\u85ac\u5264\u306e\u52b9\u679c\u3082\u3001\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u6700\u9069\u306a\u85ac\u5264\u3092\u9078\u629e\u3057\u3001\u526f\u4f5c\u7528\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) KCNJ11\u907a\u4f1d\u5b50\u3068\u30b9\u30eb\u30db\u30cb\u30eb\u5c3f\u7d20\u85ac\uff08SU\u85ac\uff09<\/strong><\/h3>\n\n\n\n<p>KCNJ11\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u30b9\u30eb\u30db\u30cb\u30eb\u5c3f\u7d20\u85ac\uff08SU\u85ac\uff09\u306e\u52b9\u679c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs5219\u306eE23K\u5909\u7570\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>SU\u85ac\u306e\u52b9\u679c\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u4f4e\u8840\u7cd6\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u60a3\u8005\u306b\u306f\u3001\u4ed6\u306e\u6cbb\u7642\u6cd5\uff08\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306a\u3069\uff09\u304c\u63a8\u5968\u3055\u308c\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18056809\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) SLC22A1\u907a\u4f1d\u5b50\u3068\u30e1\u30c8\u30db\u30eb\u30df\u30f3<\/strong><\/h3>\n\n\n\n<p>\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306f\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u7b2c\u4e00\u9078\u629e\u85ac\u3067\u3059\u304c\u3001\u305d\u306e\u52b9\u679c\u306fSLC22A1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u5909\u5316\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs628031\u306eT\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306e\u5438\u53ce\u304c\u4f4e\u4e0b\u3057\u3001\u52b9\u679c\u304c\u5f31\u307e\u308b<\/li>\n\n\n\n<li>\u9ad8\u7528\u91cf\u304c\u5fc5\u8981\u306a\u30b1\u30fc\u30b9\u304c\u5897\u3048\u308b<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u60a3\u8005\u306b\u306f\u3001\u9069\u5207\u306a\u7528\u91cf\u8abf\u6574\u3084\u4ed6\u306e\u85ac\u5264\u3068\u306e\u4f75\u7528\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18332083\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>8. \u907a\u4f1d\u5b50\u3068\u751f\u6d3b\u7fd2\u6163\u75c5\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/29959560_m-1024x585.jpg\" alt=\"\u30cf\u30f3\u30d0\u30fc\u30ac\u30fc\u3092\u98df\u3079\u308b\u7537\u6027\" class=\"wp-image-3139\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/29959560_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/29959560_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/29959560_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/29959560_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/29959560_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u306f\u3001\u4ed6\u306e\u751f\u6d3b\u7fd2\u6163\u75c5\uff08\u9ad8\u8840\u5727\u3001\u8102\u8cea\u7570\u5e38\u75c7\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\uff09\u3068\u3082\u6df1\u3044\u95a2\u9023\u304c\u3042\u308a\u307e\u3059\u3002\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u306f\u3001\u3053\u308c\u3089\u306e\u75be\u60a3\u30ea\u30b9\u30af\u304c\u540c\u6642\u306b\u4e0a\u6607\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) APOE\u907a\u4f1d\u5b50\u3068\u8102\u8cea\u4ee3\u8b1d<\/strong><\/h3>\n\n\n\n<p>APOE\uff08\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30afE\uff09\u907a\u4f1d\u5b50\u306f\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3057\u3001\u7cd6\u5c3f\u75c5\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u4e21\u65b9\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: APOE4\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08\u60aa\u7389\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff09\u304c\u4e0a\u6607<\/li>\n\n\n\n<li>\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u9ad8\u307e\u308a\u3001\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u5897\u52a0<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u8102\u8cea\u7ba1\u7406\u304c\u91cd\u8981\u3067\u3042\u308a\u3001\u5730\u4e2d\u6d77\u5f0f\u30c0\u30a4\u30a8\u30c3\u30c8\u306a\u3069\u306e\u98df\u4e8b\u7642\u6cd5\u304c\u6709\u52b9\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10788174\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>9. \u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u305f\u3081\u306e\u6804\u990a\u6226\u7565<\/strong><\/h2>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u98df\u4e8b\u306e\u5de5\u592b\u306b\u3088\u3063\u3066\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u3001\u500b\u3005\u306e\u4f53\u8cea\u306b\u5408\u3063\u305f\u6804\u990a\u6226\u7565\u3092\u5b9f\u8df5\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) \u7cd6\u8cea\u306e\u7a2e\u985e\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u6301\u3064\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u7279\u306b\u7cd6\u8cea\u306e\u7a2e\u985e\u3084\u6442\u53d6\u65b9\u6cd5\u306b\u6c17\u3092\u4ed8\u3051\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>TCF7L2\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u4f4eGI\u98df\u54c1\u3092\u4e2d\u5fc3\u306b\u98df\u4e8b\u3092\u69cb\u6210<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u767d\u7c73\u3084\u98df\u30d1\u30f3\u306e\u4ee3\u308f\u308a\u306b\u3001\u7384\u7c73\u30fb\u5168\u7c92\u7c89\u30d1\u30f3\u3092\u9078\u629e<\/li>\n\n\n\n<li>\u7802\u7cd6\u306e\u4ee3\u308f\u308a\u306b\u30b9\u30c6\u30d3\u30a2\u3084\u30a8\u30ea\u30b9\u30ea\u30c8\u30fc\u30eb\u306a\u3069\u306e\u4ee3\u66ff\u7518\u5473\u6599\u3092\u4f7f\u7528<\/li>\n\n\n\n<li>\u98df\u4e8b\u306e\u969b\u306b\u98df\u7269\u7e4a\u7dad\u3092\u5148\u306b\u6442\u53d6\u3057\u3001\u8840\u7cd6\u5024\u306e\u6025\u4e0a\u6607\u3092\u9632\u3050<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>SLC30A8\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u7cd6\u8cea\u6442\u53d6\u91cf\u3092\u9069\u5ea6\u306b\u5236\u9650<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u70ad\u6c34\u5316\u7269\u306e\u6442\u53d6\u3092\u5168\u4f53\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u6bd4\u7387\u306e45\uff5e50%\u306b\u6291\u3048\u308b<\/li>\n\n\n\n<li>1\u65e5\u306e\u7cd6\u8cea\u6442\u53d6\u91cf\u3092100\uff5e150g\u7a0b\u5ea6\u306b\u5236\u9650<\/li>\n\n\n\n<li>\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u5065\u5eb7\u7684\u306a\u8102\u8cea\u3092\u30d0\u30e9\u30f3\u30b9\u3088\u304f\u6442\u53d6<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) \u8102\u8cea\u3068\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u8102\u8cea\u306f\u5358\u306a\u308b\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u3067\u306f\u306a\u304f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3084\u708e\u75c7\u53cd\u5fdc\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FTO\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u98fd\u548c\u8102\u80aa\u9178\u306e\u6442\u53d6\u3092\u63a7\u3048\u308b<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30d0\u30bf\u30fc\u3084\u30e9\u30fc\u30c9\u306e\u4ee3\u308f\u308a\u306b\u3001\u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u3084\u30a2\u30dc\u30ab\u30c9\u30aa\u30a4\u30eb\u3092\u4f7f\u7528<\/li>\n\n\n\n<li>\u8089\u985e\u306f\u8102\u8eab\u306e\u5c11\u306a\u3044\u90e8\u4f4d\u3092\u9078\u3076\uff08\u9d8f\u3080\u306d\u8089\u3001\u8d64\u8eab\u8089\uff09<\/li>\n\n\n\n<li>\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff08EPA\u30fbDHA\uff09\u3092\u8c4a\u5bcc\u306b\u542b\u3080\u9b5a\uff08\u30b5\u30fc\u30e2\u30f3\u3001\u30b5\u30d0\uff09\u3092\u6442\u53d6<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>APOA5\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u30c8\u30e9\u30f3\u30b9\u8102\u80aa\u9178\u3092\u5b8c\u5168\u306b\u907f\u3051\u308b<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u52a0\u5de5\u98df\u54c1\u3084\u30de\u30fc\u30ac\u30ea\u30f3\u306e\u6442\u53d6\u3092\u5236\u9650<\/li>\n\n\n\n<li>\u30d5\u30a1\u30b9\u30c8\u30d5\u30fc\u30c9\u3084\u63da\u3052\u7269\u3092\u63a7\u3048\u308b<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(3) \u98df\u7269\u7e4a\u7dad\u3068\u8178\u5185\u74b0\u5883\u306e\u6539\u5584<\/strong><\/h3>\n\n\n\n<p>\u8178\u5185\u74b0\u5883\u306e\u6539\u5584\u306f\u3001\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>TLR4\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u767a\u9175\u98df\u54c1\uff08\u30e8\u30fc\u30b0\u30eb\u30c8\u3001\u7d0d\u8c46\u3001\u30ad\u30e0\u30c1\uff09\u3092\u6bce\u65e5\u6442\u308b<\/li>\n\n\n\n<li>\u6c34\u6eb6\u6027\u98df\u7269\u7e4a\u7dad\uff08\u30aa\u30fc\u30c8\u30df\u30fc\u30eb\u3001\u30a2\u30dc\u30ab\u30c9\uff09\u3092\u5897\u3084\u3059<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>FUT2\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027\u3092\u5897\u3084\u3059<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u767a\u9175\u98df\u54c1\uff0b\u98df\u7269\u7e4a\u7dad\u3092\u30d0\u30e9\u30f3\u30b9\u3088\u304f\u6442\u53d6<\/li>\n\n\n\n<li>\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u3092\u6574\u3048\u308b\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u6d3b\u7528<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>10. \u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3068\u904b\u52d5\u306e\u907a\u4f1d\u7684\u9069\u6027<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/3881952_s.jpg\" alt=\"\u30e9\u30f3\u30cb\u30f3\u30b0\u3059\u308b\u7537\u5973\" class=\"wp-image-2514\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/3881952_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/3881952_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure>\n\n\n\n<p>\u904b\u52d5\u306f\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u5f37\u529b\u306a\u624b\u6bb5\u3067\u3059\u304c\u3001\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u6700\u9069\u306a\u904b\u52d5\u30bf\u30a4\u30d7\u304c\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) \u6301\u4e45\u529b\u7cfb\u904b\u52d5\u306e\u9069\u6027<\/strong><\/h3>\n\n\n\n<p>\u6301\u4e45\u7cfb\u904b\u52d5\u306f\u3001\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3092\u6539\u5584\u3057\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u9ad8\u3081\u308b\u52b9\u679c\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PPARGC1A\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u6301\u4e45\u7cfb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u52b9\u679c\u7684<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u90313\uff5e5\u56de\u300130\uff5e60\u5206\u306e\u6709\u9178\u7d20\u904b\u52d5\uff08\u30b8\u30e7\u30ae\u30f3\u30b0\u3001\u30b5\u30a4\u30af\u30ea\u30f3\u30b0\uff09<\/li>\n\n\n\n<li>\u9ad8\u5f37\u5ea6\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08HIIT\uff09\u3092\u90311\uff5e2\u56de\u53d6\u308a\u5165\u308c\u308b<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>ACE\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u4e2d\u5f37\u5ea6\u306e\u904b\u52d5\u304c\u9069\u3057\u3066\u3044\u308b<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0\u3084\u30e8\u30ac\u306a\u3069\u3001\u7d99\u7d9a\u3057\u3084\u3059\u3044\u904b\u52d5\u3092\u512a\u5148<\/li>\n\n\n\n<li>\u904e\u5ea6\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306f\u907f\u3051\u3001\u75b2\u52b4\u3092\u6e9c\u3081\u306a\u3044\u3088\u3046\u306b\u8abf\u6574<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) \u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3068\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u7b4b\u8089\u91cf\u306e\u5897\u52a0\u306f\u3001\u7cd6\u4ee3\u8b1d\u306e\u6539\u5584\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ACTN3\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u7b4b\u30c8\u30ec\u3092\u5f37\u5316<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u90312\uff5e3\u56de\u306e\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08\u30b9\u30af\u30ef\u30c3\u30c8\u3001\u30c7\u30c3\u30c9\u30ea\u30d5\u30c8\uff09<\/li>\n\n\n\n<li>\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u904b\u52d5\u3068\u6709\u9178\u7d20\u904b\u52d5\u3092\u7d44\u307f\u5408\u308f\u305b\u308b<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>NRF2\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u56de\u5fa9\u3092\u610f\u8b58\u3057\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u904b\u52d5\u5f8c\u306e\u30b9\u30c8\u30ec\u30c3\u30c1\u3084\u30de\u30c3\u30b5\u30fc\u30b8\u3092\u7a4d\u6975\u7684\u306b\u884c\u3046<\/li>\n\n\n\n<li>\u7761\u7720\u306e\u8cea\u3092\u5411\u4e0a\u3055\u305b\u308b\u305f\u3081\u306e\u751f\u6d3b\u7fd2\u6163\u6539\u5584<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>11. \u907a\u4f1d\u5b50\u3068\u7cd6\u5c3f\u75c5\u5408\u4f75\u75c7\u306e\u30ea\u30b9\u30af<\/strong><\/h2>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba\u306f\u3001\u5408\u4f75\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306b\u3082\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) \u7cd6\u5c3f\u75c5\u6027\u814e\u75c7\u3068\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u304c\u9032\u884c\u3059\u308b\u3068\u814e\u81d3\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>EPO\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u814e\u6a5f\u80fd\u306e\u5b9a\u671f\u30c1\u30a7\u30c3\u30af\u304c\u5fc5\u8981<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u5869\u5206\u6442\u53d6\u3092\u5236\u9650\u3057\u3001\u8840\u5727\u7ba1\u7406\u3092\u5fb9\u5e95<\/li>\n\n\n\n<li>\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u5024\u3084\u5c3f\u86cb\u767d\u3092\u5b9a\u671f\u7684\u306b\u691c\u67fb<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>SLC22A12\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u5c3f\u9178\u5024\u306e\u7ba1\u7406\u304c\u91cd\u8981<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30d7\u30ea\u30f3\u4f53\u306e\u591a\u3044\u98df\u54c1\uff08\u30ec\u30d0\u30fc\u3001\u9b5a\u5375\uff09\u3092\u5236\u9650<\/li>\n\n\n\n<li>\u6c34\u5206\u3092\u3057\u3063\u304b\u308a\u6442\u53d6\u3057\u3001\u814e\u6a5f\u80fd\u3092\u7dad\u6301<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) \u7cd6\u5c3f\u75c5\u6027\u795e\u7d4c\u969c\u5bb3\u3068\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u304c\u9032\u884c\u3059\u308b\u3068\u3001\u672b\u68a2\u795e\u7d4c\u969c\u5bb3\u304c\u767a\u751f\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>NGF\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u795e\u7d4c\u7cfb\u306e\u5065\u5eb7\u3092\u7dad\u6301<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30d3\u30bf\u30df\u30f3B\u7fa4\uff08B6\u3001B12\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6<\/li>\n\n\n\n<li>\u8840\u7cd6\u7ba1\u7406\u3092\u5fb9\u5e95\u3057\u3001\u795e\u7d4c\u30c0\u30e1\u30fc\u30b8\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u308b<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>SOD2\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u6297\u9178\u5316\u5bfe\u7b56\u304c\u5fc5\u8981<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30d3\u30bf\u30df\u30f3C\u30fbE\u3092\u8c4a\u5bcc\u306b\u542b\u3080\u98df\u54c1\u3092\u6442\u308b<\/li>\n\n\n\n<li>\u904e\u5ea6\u306a\u30b9\u30c8\u30ec\u30b9\u3084\u7761\u7720\u4e0d\u8db3\u3092\u907f\u3051\u308b<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>12. \u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3068\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u306e\u907a\u4f1d\u7684\u5f71\u97ff<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/4376533_m-1024x683.jpg\" alt=\"\u6182\u9b31\u306a\u8868\u60c5\u306a\u5973\u6027\" class=\"wp-image-2810\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4376533_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4376533_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4376533_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4376533_m-1536x1025.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4376533_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30b9\u306f\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u60aa\u5316\u3055\u305b\u308b\u8981\u56e0\u306e\u4e00\u3064\u3067\u3059\u3002\u7279\u306b\u3001\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308b\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306e\u5206\u6ccc\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u500b\u4eba\u5dee\u304c\u3042\u308a\u3001\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) NR3C1\u907a\u4f1d\u5b50\u3068\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u611f\u53d7\u6027<\/strong><\/h3>\n\n\n\n<p>NR3C1\uff08\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50\u306f\u3001\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\uff08\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\uff09\u306e\u4f5c\u7528\u3092\u8abf\u7bc0\u3057\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u8eab\u4f53\u306e\u53cd\u5fdc\u3092\u6c7a\u5b9a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs6198\u306eG\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u611f\u53d7\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u8010\u6027\u304c\u4f4e\u3044<\/li>\n\n\n\n<li>\u6162\u6027\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b<\/li>\n\n\n\n<li>\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u304c1.3\uff5e1.5\u500d\u5897\u52a0<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u30e8\u30ac\u3084\u7791\u60f3\u3001\u6df1\u547c\u5438\u306a\u3069\u306e\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u6cd5\u3092\u65e5\u5e38\u7684\u306b\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15784717\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) COMT\u907a\u4f1d\u5b50\u3068\u30b9\u30c8\u30ec\u30b9\u8010\u6027<\/strong><\/h3>\n\n\n\n<p>COMT\uff08\u30ab\u30c6\u30b3\u30fc\u30eb-O-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff09\u907a\u4f1d\u5b50\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u6642\u306b\u5206\u6ccc\u3055\u308c\u308b\u30c9\u30fc\u30d1\u30df\u30f3\u3084\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs4680\u306eVal158Met\u5909\u7570\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u306e\u5206\u89e3\u304c\u9045\u304f\u3001\u30d7\u30ec\u30c3\u30b7\u30e3\u30fc\u306b\u5f31\u3044<\/li>\n\n\n\n<li>\u9577\u671f\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u304c\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u306e\u5897\u52a0\u306b\u3064\u306a\u304c\u308b<\/li>\n\n\n\n<li>\u8840\u7cd6\u5024\u306e\u4e71\u9ad8\u4e0b\u304c\u6fc0\u3057\u304f\u306a\u308b<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u9069\u5ea6\u306a\u904b\u52d5\u3084\u30ea\u30e9\u30c3\u30af\u30b9\u3059\u308b\u7fd2\u6163\u3092\u6301\u3064\u3053\u3068\u3067\u3001\u30b9\u30c8\u30ec\u30b9\u3092\u8efd\u6e1b\u3057\u8840\u7cd6\u7ba1\u7406\u3092\u6539\u5584\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12840240\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>13. \u7761\u7720\u3068\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u306e\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h2>\n\n\n\n<p>\u7761\u7720\u4e0d\u8db3\u3084\u8cea\u306e\u60aa\u3044\u7761\u7720\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u60aa\u5316\u3055\u305b\u3001\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u7761\u7720\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306f\u3001\u500b\u3005\u306e\u7761\u7720\u30d1\u30bf\u30fc\u30f3\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3068\u3082\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) CLOCK\u907a\u4f1d\u5b50\u3068\u4f53\u5185\u6642\u8a08<\/strong><\/h3>\n\n\n\n<p>CLOCK\uff08\u30b5\u30fc\u30ab\u30c7\u30a3\u30a2\u30f3\u30ea\u30ba\u30e0\u5236\u5fa1\u907a\u4f1d\u5b50\uff09\u907a\u4f1d\u5b50\u306f\u3001\u4f53\u5185\u6642\u8a08\u3092\u8abf\u7bc0\u3057\u3001\u7761\u7720\u306e\u8cea\u3084\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs1801260\u306eC\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7761\u7720\u306e\u8cea\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u591c\u578b\u50be\u5411\u304c\u5f37\u304f\u3001\u98df\u4e8b\u6642\u9593\u304c\u4e0d\u898f\u5247\u306b\u306a\u308a\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u8840\u7cd6\u5024\u306e\u5909\u52d5\u304c\u6fc0\u3057\u304f\u306a\u308a\u3001\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u304c\u5897\u52a0<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u5bdd\u308b\u524d\u306e\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\u3092\u907f\u3051\u3001\u6bce\u65e5\u540c\u3058\u6642\u9593\u306b\u5bdd\u8d77\u304d\u3059\u308b\u7fd2\u6163\u3092\u3064\u3051\u308b\u3053\u3068\u3067\u3001\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18243156\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) PER2\u907a\u4f1d\u5b50\u3068\u7761\u7720\u30ea\u30ba\u30e0<\/strong><\/h3>\n\n\n\n<p>PER2\uff08Period Circadian Regulator 2\uff09\u907a\u4f1d\u5b50\u306f\u3001\u4f53\u5185\u6642\u8a08\u306e\u30ea\u30ba\u30e0\u3092\u7dad\u6301\u3057\u3001\u7761\u7720\u30d1\u30bf\u30fc\u30f3\u3092\u5236\u5fa1\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs2304672\u306eA\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7761\u7720\u6642\u9593\u304c\u77ed\u304f\u306a\u308a\u304c\u3061<\/li>\n\n\n\n<li>\u4ea4\u4ee3\u52e4\u52d9\u3084\u591c\u66f4\u304b\u3057\u306b\u9069\u5fdc\u3057\u306b\u304f\u3044<\/li>\n\n\n\n<li>\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u304c\u4e0a\u6607<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u7761\u7720\u6642\u9593\u30927\uff5e8\u6642\u9593\u78ba\u4fdd\u3057\u3001\u6bce\u65e5\u306e\u751f\u6d3b\u30ea\u30ba\u30e0\u3092\u6574\u3048\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20663212\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>14. \u7cd6\u5c3f\u75c5\u3068\u514d\u75ab\u7cfb\u306e\u907a\u4f1d\u7684\u5f71\u97ff<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/31607714_m-1024x683.jpg\" alt=\"\u54b3\u5973\u6027\" class=\"wp-image-2997\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31607714_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31607714_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31607714_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31607714_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31607714_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u6a5f\u80fd\u306f\u3001\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u7279\u306b1\u578b\u7cd6\u5c3f\u75c5\u306f\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u3042\u308a\u3001\u514d\u75ab\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) HLA\u907a\u4f1d\u5b50\u30681\u578b\u7cd6\u5c3f\u75c5<\/strong><\/h3>\n\n\n\n<p>HLA\uff08\u30d2\u30c8\u767d\u8840\u7403\u6297\u539f\uff09\u907a\u4f1d\u5b50\u306f\u3001\u514d\u75ab\u7cfb\u306e\u50cd\u304d\u3092\u8abf\u7bc0\u3057\u30011\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: HLA-DR3\/DR4\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u81ea\u5df1\u514d\u75ab\u53cd\u5fdc\u304c\u904e\u5270\u306b\u306a\u308a\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u81b5\u5cf6\u7d30\u80de\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u5206\u6ccc\u3059\u308b\u7d30\u80de\uff09\u304c\u653b\u6483\u3055\u308c\u3084\u3059\u304f\u3001\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u611f\u67d3\u75c7\u4e88\u9632\u3084\u6297\u708e\u75c7\u4f5c\u7528\u306e\u3042\u308b\u98df\u54c1\uff08\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3001\u30d3\u30bf\u30df\u30f3D\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u514d\u75ab\u7cfb\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u4fdd\u3064\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19846892\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) IL6\u907a\u4f1d\u5b50\u3068\u6162\u6027\u708e\u75c7<\/strong><\/h3>\n\n\n\n<p>IL6\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f36\uff09\u907a\u4f1d\u5b50\u306f\u3001\u708e\u75c7\u53cd\u5fdc\u3092\u8abf\u7bc0\u3057\u3001\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs1800795\u306eC\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u708e\u75c7\u30ec\u30d9\u30eb\u304c\u9ad8\u307e\u308a\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u5897\u52a0\u3057\u30012\u578b\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u304c\u4e0a\u6607<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u6297\u708e\u75c7\u4f5c\u7528\u306e\u3042\u308b\u98df\u54c1\uff08\u30bf\u30fc\u30e1\u30ea\u30c3\u30af\u3001\u7dd1\u8336\u3001\u30c0\u30fc\u30af\u30c1\u30e7\u30b3\u30ec\u30fc\u30c8\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15059915\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>15. \u907a\u4f1d\u5b50\u3068\u7cd6\u5c3f\u75c5\u306e\u65e9\u671f\u767a\u898b\u306e\u53ef\u80fd\u6027<\/strong><\/h2>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u3001\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u4e8b\u524d\u306b\u77e5\u308b\u305f\u3081\u306e\u5f37\u529b\u306a\u30c4\u30fc\u30eb\u3067\u3059\u304c\u3001\u5358\u72ec\u3067\u8a3a\u65ad\u3092\u884c\u3046\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u3042\u304f\u307e\u3067\u30ea\u30b9\u30af\u8a55\u4fa1\u306e\u4e00\u74b0\u3067\u3042\u308a\u3001\u5b9a\u671f\u7684\u306a\u5065\u5eb7\u8a3a\u65ad\u304c\u5fc5\u8981<\/strong><\/li>\n\n\n\n<li><strong>\u5bb6\u65cf\u6b74\u304c\u3042\u308b\u5834\u5408\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3068\u4f75\u305b\u3066\u8840\u7cd6\u5024\u691c\u67fb\uff08HbA1c\u3001\u7a7a\u8179\u6642\u8840\u7cd6\u5024\uff09\u3092\u884c\u3046\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u308b<\/strong><\/li>\n\n\n\n<li><strong>\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u767a\u75c7\u3092\u672a\u7136\u306b\u9632\u3050\u53ef\u80fd\u6027\u304c\u9ad8\u307e\u308b<\/strong><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>16. \u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u305f\u3081\u306e\u500b\u5225\u5316\u533b\u7642\u306e\u53ef\u80fd\u6027<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/29204025_m-1024x683.jpg\" alt=\"\u7b11\u9854\u3067\u8a71\u3059\u5973\u6027\u60a3\u8005\u3068\u533b\u8005\u306e\u6a2a\u9854\" class=\"wp-image-8009\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/29204025_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/29204025_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/29204025_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/29204025_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/29204025_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8fd1\u5e74\u3001\u500b\u5225\u5316\u533b\u7642\uff08\u30d7\u30ec\u30b7\u30b8\u30e7\u30f3\u30fb\u30e1\u30c7\u30a3\u30b7\u30f3\uff09\u304c\u6ce8\u76ee\u3055\u308c\u3066\u304a\u308a\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u7ba1\u7406\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) \u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u3044\u305f\u4e88\u9632\u30d7\u30ed\u30b0\u30e9\u30e0<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u7d50\u679c\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u500b\u5225\u5316\u4e88\u9632\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u5b9f\u65bd\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u30ea\u30b9\u30af\u907a\u4f1d\u5b50\u3092\u6301\u3064\u4eba<\/strong> \u2192 \u53b3\u683c\u306a\u8840\u7cd6\u7ba1\u7406\u3068\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584<br>\n<ul class=\"wp-block-list\">\n<li>\u4f4eGI\u98df\u54c1\u306e\u6442\u53d6\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u98df\u4e8b\u8a08\u753b<\/li>\n\n\n\n<li>\u90315\u56de\u4ee5\u4e0a\u306e\u6709\u9178\u7d20\u904b\u52d5\u306e\u5b9f\u65bd<\/li>\n\n\n\n<li>\u5b9a\u671f\u7684\u306a\u8840\u7cd6\u5024\u6e2c\u5b9a\u3068\u533b\u5e2b\u306b\u3088\u308b\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u4e2d\u7a0b\u5ea6\u30ea\u30b9\u30af\u306e\u4eba<\/strong> \u2192 \u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u751f\u6d3b\u7fd2\u6163\u306e\u7dad\u6301<br>\n<ul class=\"wp-block-list\">\n<li>\u7cd6\u8cea\u3068\u8102\u8cea\u306e\u6442\u53d6\u30d0\u30e9\u30f3\u30b9\u3092\u8abf\u6574<\/li>\n\n\n\n<li>\u90313\uff5e4\u56de\u306e\u9069\u5ea6\u306a\u904b\u52d5\uff08\u7b4b\u30c8\u30ec\uff0b\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0\uff09<\/li>\n\n\n\n<li>\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u3084\u7761\u7720\u306e\u8cea\u3092\u5411\u4e0a<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u4f4e\u30ea\u30b9\u30af\u306e\u4eba<\/strong> \u2192 \u4e00\u822c\u7684\u306a\u5065\u5eb7\u7ba1\u7406<br>\n<ul class=\"wp-block-list\">\n<li>\u5065\u5eb7\u7684\u306a\u98df\u751f\u6d3b\u3092\u7dad\u6301\u3057\u3001\u5b9a\u671f\u7684\u306a\u904b\u52d5\u3092\u884c\u3046<\/li>\n\n\n\n<li>\u8840\u7cd6\u5024\u306e\u5b9a\u671f\u691c\u67fb\u3092\u6020\u3089\u306a\u3044<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) \u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3068AI\u3092\u6d3b\u7528\u3057\u305f\u4e88\u9632\u533b\u7642<\/strong><\/h3>\n\n\n\n<p>AI\u6280\u8853\u306e\u9032\u5316\u306b\u3088\u308a\u3001\u5927\u91cf\u306e\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3057\u3001\u500b\u4eba\u3054\u3068\u306e\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u7cbe\u5bc6\u306b\u8a55\u4fa1\u3059\u308b\u7814\u7a76\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002AI\u3092\u6d3b\u7528\u3057\u305f\u4e88\u9632\u533b\u7642\u306e\u30e1\u30ea\u30c3\u30c8\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u4e88\u6e2c\u306e\u7cbe\u5ea6\u5411\u4e0a<\/strong> \u2192 \u907a\u4f1d\u5b50\uff0b\u751f\u6d3b\u7fd2\u6163\u30c7\u30fc\u30bf\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u30ea\u30b9\u30af\u8a55\u4fa1<\/li>\n\n\n\n<li><strong>\u6700\u9069\u306a\u6cbb\u7642\u6cd5\u306e\u63d0\u6848<\/strong> \u2192 \u500b\u4eba\u306e\u907a\u4f1d\u7684\u7279\u6027\u306b\u57fa\u3065\u3044\u305f\u85ac\u7269\u7642\u6cd5\u306e\u9078\u629e<\/li>\n\n\n\n<li><strong>\u884c\u52d5\u5909\u5bb9\u306e\u4fc3\u9032<\/strong> \u2192 \u30b9\u30de\u30fc\u30c8\u30d5\u30a9\u30f3\u30a2\u30d7\u30ea\u306b\u3088\u308b\u751f\u6d3b\u7fd2\u6163\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306a\u6280\u8853\u304c\u767a\u5c55\u3059\u308c\u3070\u3001\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u3092\u672a\u7136\u306b\u9632\u3050\u65b0\u305f\u306a\u624b\u6cd5\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator 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