{"id":471,"date":"2024-11-14T01:08:44","date_gmt":"2024-11-14T01:08:44","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=471"},"modified":"2025-04-09T03:47:32","modified_gmt":"2025-04-09T03:47:32","slug":"aging-genetics-relationship","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/aging-genetics-relationship\/","title":{"rendered":"\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u898b\u308b\u8001\u5316\u306e\u30b9\u30d4\u30fc\u30c9\u3068\u5bfe\u7b56"},"content":{"rendered":"\n

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\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

1. \u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308b\u8001\u5316\u901f\u5ea6\u306e\u8a55\u4fa1<\/strong><\/p>\n\n\n\n

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\n <\/p>\n
\n

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\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

2. \u9577\u5bff\u907a\u4f1d\u5b50\u3068\u8001\u5316\u6291\u5236\u306e\u30e1\u30ab\u30cb\u30ba\u30e0<\/strong><\/p>\n\n\n\n

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\n <\/p>\n
\n

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\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

4. \u8001\u5316\u306b\u95a2\u9023\u3059\u308b\u6700\u65b0\u306e\u7814\u7a76\u52d5\u5411<\/strong><\/p>\n\n\n\n

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\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
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<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

5. \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u793e\u4f1a\u7684\u610f\u7fa9\u3068\u4eca\u5f8c\u306e\u5c55\u671b<\/strong><\/p>\n\n\n\n

\"\u4ecb\u8b77\u65bd\u8a2d\u3067\u66ae\u3089\u3059\u9ad8\u9f62\u8005\u5973\u6027\u3068\u533b\u5e2b\"<\/figure>\n\n\n\n

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\n <\/p>\n
\n

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\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

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<\/a>\n<\/div>\n<\/div>\n\n\n\n

6. \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u533b\u7642\u306e\u53ef\u80fd\u6027<\/strong><\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u3001\u5f93\u6765\u306e\u5065\u5eb7\u8a3a\u65ad\u3067\u306f\u6349\u3048\u306b\u304f\u304b\u3063\u305f\u500b\u3005\u306e\u8001\u5316\u30ea\u30b9\u30af\u3084\u75be\u60a3\u30ea\u30b9\u30af\u3092\u53ef\u8996\u5316\u3059\u308b\u5f37\u529b\u306a\u30c4\u30fc\u30eb\u3068\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u7279\u306b\u3001\u8001\u5316\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306e\u89e3\u6790\u3092\u901a\u3058\u3066\u3001\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u533b\u7642\uff08\u500b\u5225\u5316\u533b\u7642\uff09\u306e\u53ef\u80fd\u6027\u304c\u5e83\u304c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u4f8b\u3048\u3070\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u4eba\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u304f\u3001\u6d3b\u6027\u9178\u7d20\u3092\u9664\u53bb\u3059\u308b\u80fd\u529b\u304c\u4f4e\u3044\u50be\u5411\u306b\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u5834\u5408\u3001\u6297\u9178\u5316\u4f5c\u7528\u306e\u3042\u308b\u98df\u54c1\uff08\u30d3\u30bf\u30df\u30f3C\u30fbE\u3001\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306a\u3069\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001\u907a\u4f1d\u7684\u306b\u7cd6\u4ee3\u8b1d\u304c\u4f4e\u3044\u30bf\u30a4\u30d7\u306e\u4eba\u306f\u3001\u70ad\u6c34\u5316\u7269\u306e\u6442\u53d6\u3092\u63a7\u3048\u3081\u306b\u3057\u3001\u305f\u3093\u3071\u304f\u8cea\u3084\u5065\u5eb7\u7684\u306a\u8102\u8cea\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u98df\u4e8b\u3092\u5fc3\u304c\u3051\u308b\u3053\u3068\u3067\u3001\u8840\u7cd6\u5024\u306e\u6025\u4e0a\u6607\u3092\u9632\u304e\u3001\u8001\u5316\u306e\u52a0\u901f\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

\u3055\u3089\u306b\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u904b\u52d5\u7fd2\u6163\u306e\u6700\u9069\u5316\u3082\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u907a\u4f1d\u7684\u306b\u6301\u4e45\u529b\u304c\u9ad8\u3044\u30bf\u30a4\u30d7\u306e\u4eba\u306f\u3001\u6709\u9178\u7d20\u904b\u52d5\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u52b9\u7387\u7684\u306b\u5065\u5eb7\u3092\u7dad\u6301\u3067\u304d\u307e\u3059\u3002\u4e00\u65b9\u3001\u7b4b\u529b\u304c\u3064\u304d\u3084\u3059\u3044\u907a\u4f1d\u7684\u50be\u5411\u3092\u6301\u3064\u4eba\u306f\u3001\u7b4b\u30c8\u30ec\u3092\u91cd\u70b9\u7684\u306b\u884c\u3046\u3053\u3068\u3067\u5065\u5eb7\u5bff\u547d\u306e\u5ef6\u4f38\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u57fa\u306b\u500b\u3005\u306e\u4f53\u8cea\u306b\u5408\u3063\u305f\u5065\u5eb7\u7ba1\u7406\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u7387\u7684\u306b\u8001\u5316\u3092\u6291\u3048\u3001\u751f\u6d3b\u306e\u8cea\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

7. \u907a\u4f1d\u5b50\u691c\u67fb\u3068\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306e\u95a2\u4fc2<\/strong><\/p>\n\n\n\n

\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u8001\u5316\u3068\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306e\u9593\u306b\u5bc6\u63a5\u306a\u95a2\u4fc2\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u8010\u6027\u306f\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u3001\u3042\u308b\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\uff08\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\uff09\u306e\u5206\u6ccc\u304c\u904e\u5270\u306b\u306a\u308a\u3084\u3059\u304f\u3001\u305d\u308c\u304c\u8001\u5316\u3092\u52a0\u901f\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u3084\u30c9\u30fc\u30d1\u30df\u30f3\u3068\u3044\u3063\u305f\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u3001\u5e78\u798f\u611f\u3084\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u7570\u306a\u308b\u3053\u3068\u3082\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u305f\u3081\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u3005\u306e\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306e\u5f31\u70b9\u3092\u628a\u63e1\u3057\u3001\u9069\u5207\u306a\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u65b9\u6cd5\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u4f8b\u3048\u3070\u3001\u907a\u4f1d\u7684\u306b\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u4f4e\u3044\u30bf\u30a4\u30d7\u306e\u4eba\u306f\u3001\u30de\u30a4\u30f3\u30c9\u30d5\u30eb\u30cd\u30b9\u7791\u60f3\u3084\u30e8\u30ac\u306a\u3069\u306e\u30ea\u30e9\u30af\u30bc\u30fc\u30b7\u30e7\u30f3\u65b9\u6cd5\u3092\u7a4d\u6975\u7684\u306b\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u30c9\u30fc\u30d1\u30df\u30f3\u306e\u5206\u6ccc\u304c\u6d3b\u767a\u306a\u30bf\u30a4\u30d7\u306e\u4eba\u306f\u3001\u9069\u5ea6\u306a\u904b\u52d5\u3084\u65b0\u3057\u3044\u30c1\u30e3\u30ec\u30f3\u30b8\u3092\u7d9a\u3051\u308b\u3053\u3068\u3067\u3001\u30e1\u30f3\u30bf\u30eb\u306e\u5b89\u5b9a\u3092\u4fdd\u3061\u3084\u3059\u304f\u306a\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3055\u3089\u306b\u3001\u7761\u7720\u306e\u8cea\u3082\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u5f71\u97ff\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u6df1\u3044\u7761\u7720\uff08\u30ce\u30f3\u30ec\u30e0\u7761\u7720\uff09\u306e\u5272\u5408\u304c\u5c11\u306a\u304f\u3001\u7761\u7720\u306e\u8cea\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u50be\u5411\u306b\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u5834\u5408\u3001\u9069\u5207\u306a\u7761\u7720\u74b0\u5883\u3092\u6574\u3048\u305f\u308a\u3001\u30e1\u30e9\u30c8\u30cb\u30f3\u3092\u6d3b\u7528\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u3067\u3001\u7761\u7720\u306e\u8cea\u3092\u6539\u5584\u3057\u3001\u8001\u5316\u306e\u9032\u884c\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u3005\u306e\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306e\u7279\u5fb4\u3092\u7406\u89e3\u3057\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u5bfe\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

8. \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u4eca\u5f8c\u306e\u8ab2\u984c\u3068\u793e\u4f1a\u7684\u5f71\u97ff<\/strong><\/p>\n\n\n\n

\"\n\u643a\u5e2f\u96fb\u8a71\u3092\u64cd\u4f5c\u3059\u308b\u5973\u6027\u306e\u624b\u5143\"<\/figure>\n\n\n\n

\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u6280\u8853\u306f\u6025\u901f\u306b\u9032\u5316\u3057\u3066\u304a\u308a\u3001\u500b\u4eba\u306e\u5065\u5eb7\u7ba1\u7406\u3084\u8001\u5316\u5bfe\u7b56\u306b\u5927\u304d\u306a\u8ca2\u732e\u3092\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u4e00\u65b9\u3067\u3001\u3044\u304f\u3064\u304b\u306e\u8ab2\u984c\u3082\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u307e\u305a\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u7d50\u679c\u3092\u3069\u306e\u3088\u3046\u306b\u89e3\u91c8\u3057\u3001\u6d3b\u7528\u3059\u308b\u304b\u3068\u3044\u3046\u70b9\u304c\u91cd\u8981\u3067\u3059\u3002\u907a\u4f1d\u5b50\u60c5\u5831\u306f\u3042\u304f\u307e\u3067\u300c\u30ea\u30b9\u30af\u306e\u53ef\u80fd\u6027\u300d\u3092\u793a\u3059\u3082\u306e\u3067\u3042\u308a\u3001\u6c7a\u5b9a\u7684\u306a\u8a3a\u65ad\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u691c\u67fb\u7d50\u679c\u3092\u57fa\u306b\u9069\u5207\u306a\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u6539\u5584\u3092\u884c\u3046\u3053\u3068\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u306e\u53d6\u308a\u6271\u3044\u306b\u95a2\u3059\u308b\u502b\u7406\u7684\u306a\u554f\u984c\u3082\u7121\u8996\u3067\u304d\u307e\u305b\u3093\u3002\u500b\u4eba\u306e\u907a\u4f1d\u60c5\u5831\u304c\u9069\u5207\u306b\u7ba1\u7406\u3055\u308c\u3001\u7b2c\u4e09\u8005\u306b\u4e0d\u9069\u5207\u306b\u5229\u7528\u3055\u308c\u308b\u3053\u3068\u304c\u306a\u3044\u3088\u3046\u3001\u6cd5\u7684\u306a\u67a0\u7d44\u307f\u306e\u6574\u5099\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n

\u3055\u3089\u306b\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u533b\u7642\u306e\u666e\u53ca\u306b\u4f34\u3044\u3001\u7d4c\u6e08\u7684\u306a\u683c\u5dee\u306b\u3088\u308b\u5065\u5eb7\u683c\u5dee\u306e\u62e1\u5927\u304c\u61f8\u5ff5\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u4eba\u3068\u3067\u304d\u306a\u3044\u4eba\u3068\u306e\u9593\u3067\u3001\u8001\u5316\u5bfe\u7b56\u3084\u5065\u5eb7\u7ba1\u7406\u306b\u304a\u3044\u3066\u5dee\u304c\u751f\u3058\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u516c\u5e73\u306a\u533b\u7642\u30a2\u30af\u30bb\u30b9\u306e\u78ba\u4fdd\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u3046\u3057\u305f\u8ab2\u984c\u3092\u4e57\u308a\u8d8a\u3048\u306a\u304c\u3089\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u6280\u8853\u304c\u3088\u308a\u591a\u304f\u306e\u4eba\u306b\u3068\u3063\u3066\u6709\u76ca\u306a\u3082\u306e\u3068\u306a\u308b\u3088\u3046\u3001\u4eca\u5f8c\u306e\u767a\u5c55\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

9. \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u6700\u65b0\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u6280\u8853<\/strong><\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u691c\u67fb\u304c\u9032\u5316\u3059\u308b\u4e2d\u3067\u3001\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\uff08\u6297\u8001\u5316\uff09\u5206\u91ce\u3067\u3082\u5927\u304d\u306a\u9032\u5c55\u304c\u898b\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u3001\u8001\u5316\u306e\u30b9\u30d4\u30fc\u30c9\u3092\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u89e3\u6790\u3057\u3001\u500b\u4eba\u306b\u9069\u3057\u305f\u5bfe\u7b56\u3092\u7acb\u3066\u308b\u65b0\u305f\u306a\u6280\u8853\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

9.1 \u5e79\u7d30\u80de\u7642\u6cd5\u3068\u907a\u4f1d\u5b50\u691c\u67fb<\/strong><\/h3>\n\n\n\n

\u5e79\u7d30\u80de\u7642\u6cd5\u306f\u3001\u8001\u5316\u3057\u305f\u7d30\u80de\u3092\u82e5\u8fd4\u3089\u305b\u308b\u6700\u5148\u7aef\u306e\u6cbb\u7642\u6cd5\u306e\u4e00\u3064\u3067\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u3066\u500b\u4eba\u306e\u5e79\u7d30\u80de\u306e\u72b6\u614b\u3092\u89e3\u6790\u3057\u3001\u305d\u308c\u306b\u57fa\u3065\u3044\u3066\u6700\u9069\u306a\u6cbb\u7642\u65b9\u6cd5\u3092\u9078\u629e\u3059\u308b\u8a66\u307f\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u4f8b\u3048\u3070\u3001\u8001\u5316\u304c\u9032\u3080\u3068\u4f53\u5185\u306e\u5e79\u7d30\u80de\u306e\u518d\u751f\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u307e\u3059\u304c\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u30de\u30fc\u30ab\u30fc\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u5e79\u7d30\u80de\u306e\u6a5f\u80fd\u4f4e\u4e0b\u3092\u65e9\u671f\u306b\u5bdf\u77e5\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u5e79\u7d30\u80de\u306e\u88dc\u5145\u6cbb\u7642\u3084\u518d\u751f\u533b\u7642\u3092\u53d7\u3051\u308b\u3053\u3068\u3067\u3001\u8001\u5316\u306e\u9032\u884c\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

9.2 NAD+\u88dc\u5145\u7642\u6cd5\u3068\u907a\u4f1d\u5b50\u691c\u67fb<\/strong><\/h3>\n\n\n\n

NAD+\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30a2\u30c7\u30cb\u30f3\u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff09\u306f\u3001\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3084DNA\u4fee\u5fa9\u306b\u95a2\u4e0e\u3059\u308b\u91cd\u8981\u306a\u5206\u5b50\u3067\u3059\u304c\u3001\u52a0\u9f62\u3068\u3068\u3082\u306b\u305d\u306e\u30ec\u30d9\u30eb\u304c\u6e1b\u5c11\u3057\u307e\u3059\u3002NAD+\u306e\u6e1b\u5c11\u306f\u3001\u7d30\u80de\u306e\u8001\u5316\u3092\u52a0\u901f\u3055\u305b\u308b\u8981\u56e0\u306e\u4e00\u3064\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u6700\u65b0\u306e\u907a\u4f1d\u5b50\u7814\u7a76\u3067\u306f\u3001NAD+\u306e\u751f\u6210\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u89e3\u6790\u3057\u3001\u500b\u4eba\u3054\u3068\u306b\u6700\u9069\u306a\u88dc\u5145\u65b9\u6cd5\u3092\u63d0\u6848\u3059\u308b\u6280\u8853\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u907a\u4f1d\u7684\u306bNAD+\u306e\u751f\u7523\u80fd\u529b\u304c\u4f4e\u3044\u30bf\u30a4\u30d7\u306e\u4eba\u306b\u306f\u3001NMN\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30e2\u30ce\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff09\u3084NR\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30ea\u30dc\u30b7\u30c9\uff09\u3068\u3044\u3063\u305f\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6442\u53d6\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001NAD+\u306e\u6e1b\u5c11\u3092\u9632\u3050\u305f\u3081\u306b\u3001\u65ad\u98df\uff08\u30d5\u30a1\u30b9\u30c6\u30a3\u30f3\u30b0\uff09\u3084\u9069\u5ea6\u306a\u904b\u52d5\u304c\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u3082\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u5909\u5316\u3092\u907a\u4f1d\u5b50\u691c\u67fb\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u8001\u5316\u4e88\u9632\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

10. \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u7f8e\u5bb9\u5206\u91ce\u306e\u9032\u5316<\/strong><\/p>\n\n\n\n

\"\u30df\u30c9\u30eb\u5973\u6027\u306e\u30d3\u30e5\u30fc\u30c6\u30a3\u30fc\"<\/figure>\n\n\n\n

10.1 \u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308b\u808c\u8001\u5316\u306e\u4e88\u6e2c\u3068\u30b1\u30a2<\/strong><\/h3>\n\n\n\n

\u808c\u306e\u8001\u5316\u306b\u306f\u3001\u7d2b\u5916\u7dda\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3001\u7cd6\u5316\u306a\u3069\u306e\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306e\u5f71\u97ff\u3092\u3069\u306e\u7a0b\u5ea6\u53d7\u3051\u3084\u3059\u3044\u304b\u306f\u907a\u4f1d\u7684\u306a\u8981\u56e0\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u8fd1\u5e74\u3001\u7f8e\u5bb9\u30af\u30ea\u30cb\u30c3\u30af\u3067\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u5229\u7528\u3057\u3066\u808c\u306e\u8001\u5316\u30ea\u30b9\u30af\u3092\u89e3\u6790\u3057\u3001\u500b\u5225\u306b\u6700\u9069\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u3092\u63d0\u6848\u3059\u308b\u30b5\u30fc\u30d3\u30b9\u304c\u767b\u5834\u3057\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u751f\u6210\u3092\u4fc3\u3059\u907a\u4f1d\u5b50\uff08COL1A1\uff09\u304c\u5909\u7570\u3057\u3066\u3044\u308b\u5834\u5408\u306f\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6442\u53d6\u3084\u30ec\u30c1\u30ce\u30fc\u30eb\u3092\u542b\u3080\u30b9\u30ad\u30f3\u30b1\u30a2\u88fd\u54c1\u306e\u4f7f\u7528\u304c\u52e7\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001\u6297\u9178\u5316\u529b\u304c\u4f4e\u3044\u907a\u4f1d\u7684\u50be\u5411\u3092\u6301\u3064\u4eba\u306f\u3001\u30d3\u30bf\u30df\u30f3C\u3084E\u3092\u591a\u304f\u542b\u3080\u30b9\u30ad\u30f3\u30b1\u30a2\u3084\u98df\u4e8b\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u3001\u808c\u306e\u8001\u5316\u3092\u9632\u3050\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

10.2 \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u6bdb\u9aea\u30b1\u30a2<\/strong><\/h3>\n\n\n\n

\u9aea\u306e\u5065\u5eb7\u3082\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u5de6\u53f3\u3055\u308c\u307e\u3059\u3002\u7279\u306b\u3001AGA\uff08\u7537\u6027\u578b\u8131\u6bdb\u75c7\uff09\u3084FAGA\uff08\u5973\u6027\u578b\u8131\u6bdb\u75c7\uff09\u306e\u30ea\u30b9\u30af\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u3063\u3066\u4e88\u6e2c\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n

\u4f8b\u3048\u3070\u3001\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u30ec\u30bb\u30d7\u30bf\u30fc\u907a\u4f1d\u5b50\uff08AR\uff09\u306e\u5909\u7570\u304c\u3042\u308b\u5834\u5408\u3001DHT\uff08\u30b8\u30d2\u30c9\u30ed\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\uff09\u3068\u3044\u3046\u30db\u30eb\u30e2\u30f3\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u304f\u3001\u8584\u6bdb\u304c\u9032\u884c\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u5834\u5408\u3001DHT\u306e\u751f\u6210\u3092\u6291\u3048\u308b\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u3084\u30c7\u30e5\u30bf\u30b9\u30c6\u30ea\u30c9\u3068\u3044\u3063\u305f\u6cbb\u7642\u85ac\u304c\u6709\u52b9\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001\u8840\u6d41\u3092\u6539\u5584\u3057\u3001\u6bdb\u6bcd\u7d30\u80de\u306e\u6d3b\u6027\u3092\u4fc3\u3059\u30df\u30ce\u30ad\u30b7\u30b8\u30eb\u306e\u4f7f\u7528\u3082\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3092\u8003\u616e\u3057\u305f\u6cbb\u7642\u3068\u3057\u3066\u63a8\u5968\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

11. \u907a\u4f1d\u5b50\u691c\u67fb\u3068\u98df\u4e8b\u306e\u95a2\u4fc2<\/strong><\/p>\n\n\n\n

11.1 \u907a\u4f1d\u5b50\u3068\u6804\u990a\u306e\u95a2\u4fc2\uff08\u30cb\u30e5\u30fc\u30c8\u30ea\u30b2\u30ce\u30df\u30af\u30b9\uff09<\/strong><\/h3>\n\n\n\n

\u98df\u4e8b\u306e\u5f71\u97ff\u3092\u3069\u306e\u7a0b\u5ea6\u53d7\u3051\u3084\u3059\u3044\u304b\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u8102\u8cea\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\uff08APOE\uff09\u306e\u30bf\u30a4\u30d7\u306b\u3088\u3063\u3066\u3001\u8102\u80aa\u306e\u4ee3\u8b1d\u80fd\u529b\u304c\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

APOE4\u578b\u306e\u907a\u4f1d\u5b50\u3092\u6301\u3064\u4eba\u306f\u3001\u98fd\u548c\u8102\u80aa\u9178\u306e\u6442\u53d6\u306b\u3088\u3063\u3066\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u3084\u30ca\u30c3\u30c4\u985e\u306b\u542b\u307e\u308c\u308b\u4e0d\u98fd\u548c\u8102\u80aa\u9178\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u98df\u4e8b\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001\u907a\u4f1d\u7684\u306b\u4e73\u7cd6\u4e0d\u8010\u6027\u306e\u50be\u5411\u304c\u3042\u308b\u5834\u5408\u306f\u3001\u4e73\u88fd\u54c1\u306e\u6442\u53d6\u3092\u63a7\u3048\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u3092\u4ed6\u306e\u98df\u54c1\uff08\u5c0f\u9b5a\u3084\u8c46\u985e\uff09\u304b\u3089\u6442\u308b\u5de5\u592b\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

11.2 \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u30c0\u30a4\u30a8\u30c3\u30c8<\/strong><\/h3>\n\n\n\n
\"\u4f53\u91cd\u8a08\u306b\u4e57\u3063\u305f\u8db3\u5143\u3000\u30c0\u30a4\u30a8\u30c3\u30c8\u30a4\u30e1\u30fc\u30b8\"<\/figure>\n\n\n\n

\u30c0\u30a4\u30a8\u30c3\u30c8\u306e\u6210\u529f\u7387\u3082\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001FTO\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba\u306f\u3001\u98df\u6b32\u304c\u5897\u3057\u3084\u3059\u304f\u3001\u4f53\u8102\u80aa\u304c\u84c4\u7a4d\u3057\u3084\u3059\u3044\u50be\u5411\u306b\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u5834\u5408\u3001\u98df\u4e8b\u306e\u91cf\u3092\u610f\u8b58\u7684\u306b\u8abf\u6574\u3057\u3001\u98df\u7269\u7e4a\u7dad\u3092\u591a\u304f\u542b\u3080\u98df\u54c1\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u304c\u52b9\u679c\u7684\u3067\u3059\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001\u907a\u4f1d\u7684\u306b\u7cd6\u8cea\u306e\u4ee3\u8b1d\u304c\u9045\u3044\u30bf\u30a4\u30d7\u306e\u4eba\u306f\u3001\u4f4e\u70ad\u6c34\u5316\u7269\u30c0\u30a4\u30a8\u30c3\u30c8\u304c\u52b9\u679c\u7684\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u9006\u306b\u3001\u8102\u80aa\u4ee3\u8b1d\u304c\u5f97\u610f\u306a\u30bf\u30a4\u30d7\u306e\u4eba\u306f\u3001\u9ad8\u8102\u8cea\u30fb\u4f4e\u7cd6\u8cea\u306e\u30b1\u30c8\u30b8\u30a7\u30cb\u30c3\u30af\u30c0\u30a4\u30a8\u30c3\u30c8\u304c\u9069\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u308c\u3089\u306e\u60c5\u5831\u3092\u3082\u3068\u306b\u3001\u81ea\u5206\u306b\u5408\u3063\u305f\u98df\u4e8b\u6cd5\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u3067\u3001\u7121\u7406\u306a\u304f\u5065\u5eb7\u7684\u306a\u4f53\u578b\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

12. \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u904b\u52d5\u6700\u9069\u5316<\/strong><\/p>\n\n\n\n

12.1 \u907a\u4f1d\u5b50\u3068\u7b4b\u8089\u306e\u30bf\u30a4\u30d7<\/strong><\/h3>\n\n\n\n

\u904b\u52d5\u306e\u52b9\u679c\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u3001\u305d\u306e\u9055\u3044\u306f\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u8aac\u660e\u3067\u304d\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001ACTN3\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\uff08R577X\uff09\u306b\u3088\u3063\u3066\u3001\u901f\u7b4b\uff08\u77ac\u767a\u529b\uff09\u3068\u9045\u7b4b\uff08\u6301\u4e45\u529b\uff09\u306e\u5272\u5408\u304c\u6c7a\u307e\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

ACTN3\u306eRR\u578b\u3092\u6301\u3064\u4eba\u306f\u901f\u7b4b\u304c\u767a\u9054\u3057\u3084\u3059\u304f\u3001\u77ed\u8ddd\u96e2\u8d70\u3084\u91cd\u91cf\u6319\u3052\u306e\u3088\u3046\u306a\u77ac\u767a\u529b\u3092\u8981\u3059\u308b\u904b\u52d5\u306b\u5411\u3044\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001XX\u578b\u306e\u4eba\u306f\u6301\u4e45\u529b\u304c\u9ad8\u304f\u3001\u30de\u30e9\u30bd\u30f3\u3084\u9577\u6642\u9593\u306e\u6709\u9178\u7d20\u904b\u52d5\u306b\u9069\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u907a\u4f1d\u7684\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u4eba\u306b\u6700\u9069\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u65b9\u6cd5\u3092\u9078\u629e\u3057\u3001\u3088\u308a\u52b9\u7387\u7684\u306b\u4f53\u3092\u935b\u3048\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u7b4b\u80a5\u5927\u3092\u76ee\u7684\u3068\u3059\u308b\u5834\u5408\u3001RR\u578b\u306e\u4eba\u306f\u9ad8\u8ca0\u8377\u30fb\u4f4e\u56de\u6570\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u9069\u3057\u3066\u304a\u308a\u3001XX\u578b\u306e\u4eba\u306f\u4f4e\u8ca0\u8377\u30fb\u9ad8\u56de\u6570\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u52b9\u679c\u7684\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

12.2 \u907a\u4f1d\u5b50\u3068\u56de\u5fa9\u529b\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n

\u904b\u52d5\u5f8c\u306e\u56de\u5fa9\u901f\u5ea6\u306b\u3082\u907a\u4f1d\u7684\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001IL6\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u708e\u75c7\u53cd\u5fdc\u304c\u5f37\u304f\u51fa\u3084\u3059\u3044\u305f\u3081\u3001\u904b\u52d5\u5f8c\u306e\u7b4b\u8089\u75db\u304c\u9577\u5f15\u304f\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u30bf\u30a4\u30d7\u306e\u4eba\u306f\u3001\u904b\u52d5\u5f8c\u306e\u30b9\u30c8\u30ec\u30c3\u30c1\u3084\u30a2\u30a4\u30b9\u30d0\u30b9\u3001\u5341\u5206\u306a\u7761\u7720\u3092\u53d6\u308b\u3053\u3068\u3067\u56de\u5fa9\u3092\u4fc3\u9032\u3067\u304d\u307e\u3059\u3002\u307e\u305f\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3092\u542b\u3080\u98df\u54c1\uff08\u30b5\u30fc\u30e2\u30f3\u3001\u304f\u308b\u307f\u3001\u30c1\u30a2\u30b7\u30fc\u30c9\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u708e\u75c7\u3092\u6291\u3048\u308b\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

\u4e00\u65b9\u3001\u56de\u5fa9\u529b\u304c\u9ad8\u3044\u907a\u4f1d\u7684\u50be\u5411\u3092\u6301\u3064\u4eba\u306f\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u983b\u5ea6\u3092\u9ad8\u3081\u308b\u3053\u3068\u3067\u3088\u308a\u77ed\u671f\u9593\u3067\u6210\u679c\u3092\u51fa\u3059\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

12.3 \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong><\/h3>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\u8fd1\u5e74\u3001\u30b9\u30dd\u30fc\u30c4\u30b8\u30e0\u3084\u30d5\u30a3\u30c3\u30c8\u30cd\u30b9\u696d\u754c\u3067\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u5c0e\u5165\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u4f8b\u3048\u3070\u3001\u6301\u4e45\u529b\u304c\u9ad8\u3044\u907a\u4f1d\u7684\u7279\u5fb4\u3092\u6301\u3064\u4eba\u306b\u306f\u3001\u30e9\u30f3\u30cb\u30f3\u30b0\u3084\u30b5\u30a4\u30af\u30ea\u30f3\u30b0\u306a\u3069\u306e\u6709\u9178\u7d20\u904b\u52d5\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u63a8\u5968\u3055\u308c\u308b\u4e00\u65b9\u3001\u7b4b\u529b\u304c\u3064\u304d\u3084\u3059\u3044\u4eba\u306b\u306f\u30a6\u30a7\u30a4\u30c8\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u4e3b\u4f53\u306e\u30e1\u30cb\u30e5\u30fc\u304c\u7d44\u307e\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u3055\u3089\u306b\u3001\u9178\u7d20\u904b\u642c\u80fd\u529b\u3092\u6c7a\u5b9a\u3059\u308bVEGF\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u9069\u6027\u3082\u5224\u65ad\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u3001\u30a2\u30b9\u30ea\u30fc\u30c8\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u5411\u4e0a\u306b\u6d3b\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

13. \u907a\u4f1d\u5b50\u3068\u514d\u75ab\u529b\u306e\u95a2\u4fc2<\/strong><\/p>\n\n\n\n

13.1 \u907a\u4f1d\u5b50\u304c\u514d\u75ab\u529b\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/strong><\/h3>\n\n\n\n

\u514d\u75ab\u529b\u306e\u5f37\u3055\u3082\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002HLA\u907a\u4f1d\u5b50\uff08\u30d2\u30c8\u767d\u8840\u7403\u6297\u539f\uff09\u306f\u3001\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u50cd\u304d\u3092\u6c7a\u5b9a\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u3053\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u306b\u3088\u3063\u3066\u611f\u67d3\u75c7\u3084\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u5909\u308f\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u4f8b\u3048\u3070\u3001HLA-B27\u3092\u6301\u3064\u4eba\u306f\u81ea\u5df1\u514d\u75ab\u75be\u60a3\uff08\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3001\u4e7e\u766c\u6027\u95a2\u7bc0\u708e\u306a\u3069\uff09\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30bf\u30a4\u30d7\u306e\u4eba\u306f\u3001\u8178\u5185\u74b0\u5883\u3092\u6574\u3048\u308b\u3053\u3068\u3067\u514d\u75ab\u30d0\u30e9\u30f3\u30b9\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001TLR\u907a\u4f1d\u5b50\uff08\u30c8\u30fc\u30eb\u69d8\u53d7\u5bb9\u4f53\uff09\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u3001\u30a6\u30a4\u30eb\u30b9\u3084\u7d30\u83cc\u306b\u5bfe\u3059\u308b\u514d\u75ab\u53cd\u5fdc\u306e\u5f37\u3055\u304c\u6c7a\u307e\u308b\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u305f\u3081\u3001\u907a\u4f1d\u7684\u306b\u514d\u75ab\u5fdc\u7b54\u304c\u5f31\u3044\u30bf\u30a4\u30d7\u306e\u4eba\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u3084\u4e9c\u925b\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3057\u3001\u9069\u5ea6\u306a\u904b\u52d5\u3092\u884c\u3046\u3053\u3068\u3067\u514d\u75ab\u529b\u3092\u5f37\u5316\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

13.2 \u907a\u4f1d\u5b50\u691c\u67fb\u3068\u30ef\u30af\u30c1\u30f3\u306e\u52b9\u679c<\/strong><\/h3>\n\n\n\n

\u30ef\u30af\u30c1\u30f3\u306e\u52b9\u679c\u3082\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001HLA\u306e\u578b\u306b\u3088\u3063\u3066\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306e\u6297\u4f53\u7523\u751f\u91cf\u306b\u9055\u3044\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u305f\u3081\u3001\u500b\u4eba\u306eHLA\u578b\u3092\u4e8b\u524d\u306b\u691c\u67fb\u3059\u308b\u3053\u3068\u3067\u3001\u30ef\u30af\u30c1\u30f3\u306e\u52b9\u679c\u3092\u6700\u5927\u9650\u306b\u5f15\u304d\u51fa\u3059\u305f\u3081\u306e\u8ffd\u52a0\u63a5\u7a2e\u3084\u7570\u306a\u308b\u30ef\u30af\u30c1\u30f3\u306e\u9078\u629e\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

14. \u907a\u4f1d\u5b50\u691c\u67fb\u3068\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306e\u6700\u65b0\u7814\u7a76<\/strong><\/p>\n\n\n\n

14.1 \u907a\u4f1d\u5b50\u3068\u30b9\u30c8\u30ec\u30b9\u8010\u6027<\/strong><\/h3>\n\n\n\n
\"\u7720\u305f\u3052\u306a\u30d3\u30b8\u30cd\u30b9\u30a6\u30fc\u30de\u30f3\"<\/figure>\n\n\n\n

\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u8010\u6027\u306f\u3001COMT\u907a\u4f1d\u5b50\uff08\u30ab\u30c6\u30b3\u30fc\u30eb-O-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff09\u306b\u3088\u3063\u3066\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u306b\u3088\u3063\u3066\u3001\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\uff08\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\uff09\u306e\u5206\u89e3\u901f\u5ea6\u304c\u5909\u308f\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

COMT\u306e\u50cd\u304d\u304c\u5f37\u3044\u30bf\u30a4\u30d7\u306e\u4eba\u306f\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u9ad8\u304f\u3001\u51b7\u9759\u306a\u5224\u65ad\u304c\u3067\u304d\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u4e00\u65b9\u3001COMT\u306e\u50cd\u304d\u304c\u5f31\u3044\u30bf\u30a4\u30d7\u306e\u4eba\u306f\u30b9\u30c8\u30ec\u30b9\u3092\u611f\u3058\u3084\u3059\u304f\u3001\u4e0d\u5b89\u306b\u306a\u308a\u3084\u3059\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u305f\u3081\u3001\u30b9\u30c8\u30ec\u30b9\u3092\u8efd\u6e1b\u3059\u308b\u305f\u3081\u306b\u9069\u5207\u306a\u5bfe\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u304c\u91cd\u8981\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

14.2 \u907a\u4f1d\u5b50\u3068\u7761\u7720\u306e\u8cea<\/strong><\/h3>\n\n\n\n

\u7761\u7720\u306e\u8cea\u3082\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u6c7a\u307e\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001ADRB1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba\u306f\u3001\u77ed\u6642\u9593\u7761\u7720\u3067\u3082\u6bd4\u8f03\u7684\u5143\u6c17\u306b\u6d3b\u52d5\u3067\u304d\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001PER3\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u591c\u578b\u306e\u50be\u5411\u304c\u5f37\u304f\u3001\u671d\u306e\u76ee\u899a\u3081\u304c\u60aa\u3044\u50be\u5411\u306b\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u3088\u3046\u306a\u907a\u4f1d\u7684\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u81ea\u5206\u306b\u5408\u3063\u305f\u7761\u7720\u7fd2\u6163\u3092\u78ba\u7acb\u3057\u3001\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u591c\u578b\u306e\u4eba\u306f\u671d\u65e5\u3092\u6d74\u3073\u308b\u6642\u9593\u3092\u5897\u3084\u3059\u3053\u3068\u3067\u3001\u4f53\u5185\u6642\u8a08\u3092\u30ea\u30bb\u30c3\u30c8\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u907a\u4f1d\u7684\u306b\u6df1\u3044\u7761\u7720\u304c\u5f97\u306b\u304f\u3044\u30bf\u30a4\u30d7\u306e\u4eba\u306f\u3001\u30e1\u30e9\u30c8\u30cb\u30f3\u3092\u6d3b\u7528\u3057\u305f\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u6709\u52b9\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\n\n\n\n

15. \u907a\u4f1d\u5b50\u691c\u67fb\u3068\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u9078\u3073\u65b9<\/strong><\/p>\n\n\n\n

15.1 \u907a\u4f1d\u5b50\u306b\u57fa\u3065\u3044\u305f\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6700\u9069\u5316<\/strong><\/h3>\n\n\n\n

\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u306b\u52b9\u679c\u304c\u3042\u308b\u3068\u3055\u308c\u308b\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3082\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306b\u9078\u629e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

\u4f8b\u3048\u3070\u3001\u6297\u9178\u5316\u529b\u304c\u4f4e\u3044\u907a\u4f1d\u7684\u50be\u5411\u3092\u6301\u3064\u4eba\u306f\u3001\u30d3\u30bf\u30df\u30f3C\u3001\u30d3\u30bf\u30df\u30f3E\u3001\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0Q10\uff08CoQ10\uff09\u3001\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u306a\u3069\u306e\u6297\u9178\u5316\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6442\u53d6\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u6210\u5206\u306f\u3001\u7d30\u80de\u3092\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u5b88\u308a\u3001\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001NAD+\u306e\u751f\u6210\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306b\u306f\u3001NMN\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30e2\u30ce\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff09\u3084NR\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30ea\u30dc\u30b7\u30c9\uff09\u306e\u6442\u53d6\u304c\u6709\u52b9\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u6210\u5206\u306f\u3001\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u4fc3\u9032\u3057\u3001\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

15.2 \u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308b\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u56de\u907f<\/strong><\/h3>\n\n\n\n
\"\n\u85ac\u3092\u6301\u3064\u624b21\"<\/figure>\n\n\n\n

\u4e00\u65b9\u3067\u3001\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u306f\u7279\u5b9a\u306e\u6804\u990a\u7d20\u304c\u4f53\u306b\u5408\u308f\u306a\u3044\u30b1\u30fc\u30b9\u3082\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001MTHFR\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba\u306f\u3001\u8449\u9178\u306e\u4ee3\u8b1d\u304c\u3046\u307e\u304f\u3044\u304b\u306a\u3044\u305f\u3081\u3001\u901a\u5e38\u306e\u8449\u9178\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3067\u306f\u306a\u304f\u300c\u30e1\u30c1\u30eb\u8449\u9178\u300d\u306e\u5f62\u3067\u6442\u53d6\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001\u9244\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308bHFE\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308b\u4eba\u306f\u3001\u9244\u5206\u3092\u904e\u5270\u306b\u6442\u53d6\u3059\u308b\u3068\u4f53\u5185\u306b\u84c4\u7a4d\u3057\u3084\u3059\u304f\u306a\u308a\u3001\u5065\u5eb7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u9078\u629e\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u81ea\u5206\u306e\u4f53\u306b\u6700\u9069\u306a\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u9078\u3073\u3001\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u305f\u3081\u306e\u52b9\u679c\u7684\u306a\u5bfe\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u898b\u3048\u308b\u8001\u5316\u306e\u30b9\u30d4\u30fc\u30c9\u3068\u5bfe\u7b56<\/strong><\/h3>\n\n\n\n

\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u8001\u5316\u306e\u9032\u884c\u901f\u5ea6\u3084\u5065\u5eb7\u30ea\u30b9\u30af\u3092\u628a\u63e1\u3057\u3001\u500b\u5225\u306b\u6700\u9069\u306a\u5bfe\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u30af\u30ed\u30c3\u30af\u3092\u7528\u3044\u305f\u751f\u7269\u5b66\u7684\u5e74\u9f62\u306e\u6e2c\u5b9a\u3001\u9577\u5bff\u907a\u4f1d\u5b50\u306e\u89e3\u6790\u3001\u98df\u4e8b\u3084\u904b\u52d5\u306e\u6700\u9069\u5316\u3001\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306e\u7ba1\u7406\u306a\u3069\u3001\u591a\u65b9\u9762\u3067\u306e\u5fdc\u7528\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u6700\u65b0\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u6280\u8853\u3084\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u9078\u629e\u3082\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u57fa\u306b\u30ab\u30b9\u30bf\u30de\u30a4\u30ba\u3067\u304d\u308b\u6642\u4ee3\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u81ea\u8eab\u306e\u907a\u4f1d\u7684\u50be\u5411\u3092\u7406\u89e3\u3057\u3001\u751f\u6d3b\u7fd2\u6163\u3092\u6700\u9069\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u5065\u5eb7\u5bff\u547d\u3092\u5ef6\u3070\u3057\u3001\u3088\u308a\u5145\u5b9f\u3057\u305f\u4eba\u751f\u3092\u9001\u308b\u3053\u3068\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u7c21\u5358\u30fb\u5b89\u5fc3\uff01
\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\u307e\u3068\u3081<\/strong><\/p>\n\n\n\n

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\n <\/p>\n
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\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n

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