{"id":687,"date":"2024-12-06T01:57:05","date_gmt":"2024-12-06T01:57:05","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=687"},"modified":"2025-02-14T03:10:42","modified_gmt":"2025-02-14T03:10:42","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e6%83%85%e5%a0%b1%e3%81%a7%e7%ae%a1%e7%90%86%e3%81%99%e3%82%8b%e3%82%a2%e3%83%ac%e3%83%ab%e3%82%ae%e3%83%bc%e3%81%a8%e7%97%87%e7%8a%b6%e3%81%ae%e8%bb%bd%e6%b8%9b","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e6%83%85%e5%a0%b1%e3%81%a7%e7%ae%a1%e7%90%86%e3%81%99%e3%82%8b%e3%82%a2%e3%83%ac%e3%83%ab%e3%82%ae%e3%83%bc%e3%81%a8%e7%97%87%e7%8a%b6%e3%81%ae%e8%bb%bd%e6%b8%9b\/","title":{"rendered":"\u907a\u4f1d\u5b50\u60c5\u5831\u3067\u7ba1\u7406\u3059\u308b\u30a2\u30ec\u30eb\u30ae\u30fc\u3068\u75c7\u72b6\u306e\u8efd\u6e1b"},"content":{"rendered":"\n<p>\u30a2\u30ec\u30eb\u30ae\u30fc\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u304c\u76f8\u4e92\u306b\u4f5c\u7528\u3057\u3066\u767a\u75c7\u3059\u308b\u514d\u75ab\u7cfb\u306e\u7570\u5e38\u53cd\u5fdc\u3067\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u306e\u767a\u75c7\u3084\u91cd\u75c7\u5ea6\u306b\u306f\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u500b\u5225\u6700\u9069\u5316\u3055\u308c\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u7ba1\u7406<\/strong>\u304c\u53ef\u80fd\u306b\u306a\u308a\u3001\u75c7\u72b6\u306e\u8efd\u6e1b\u3084\u767a\u75c7\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\u306b\u3064\u306a\u304c\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u672c\u8a18\u4e8b\u3067\u306f\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u3068\u907a\u4f1d\u306e\u95a2\u4fc2\u3001\u4e3b\u8981\u306a\u30a2\u30ec\u30eb\u30ae\u30fc\u95a2\u9023\u907a\u4f1d\u5b50\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u7ba1\u7406\u65b9\u6cd5\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>1. \u30a2\u30ec\u30eb\u30ae\u30fc\u3068\u907a\u4f1d\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u306b\u306f\u3001\u82b1\u7c89\u75c7\u3001\u5598\u606f\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3001\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306a\u3069\u3055\u307e\u3056\u307e\u306a\u7a2e\u985e\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u75be\u60a3\u306f\u3001<strong>\u514d\u75ab\u7cfb\u304c\u7279\u5b9a\u306e\u7269\u8cea\uff08\u30a2\u30ec\u30eb\u30b2\u30f3\uff09\u306b\u5bfe\u3057\u3066\u904e\u5270\u53cd\u5fdc\u3092\u793a\u3059\u3053\u3068\u3067\u767a\u75c7<\/strong>\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) \u907a\u4f1d\u306e\u5f71\u97ff\u306f\u3069\u306e\u304f\u3089\u3044\uff1f<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u3068\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u95a2\u9023\u6027\u3092\u793a\u3059\u7814\u7a76\u306e\u4e00\u3064\u306b\u3001<strong>\u53cc\u751f\u5150\u7814\u7a76<\/strong>\u304c\u3042\u308a\u307e\u3059\u3002\u907a\u4f1d\u7684\u306b\u540c\u4e00\u306e\u4e00\u5375\u6027\u53cc\u751f\u5150\u3068\u3001\u907a\u4f1d\u5b50\u306e50%\u3092\u5171\u6709\u3059\u308b\u4e8c\u5375\u6027\u53cc\u751f\u5150\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u767a\u75c7\u7387\u3092\u6bd4\u8f03\u3059\u308b\u3068\u3001<strong>\u4e00\u5375\u6027\u53cc\u751f\u5150\u306e\u65b9\u304c\u767a\u75c7\u7387\u304c\u9ad8\u3044<\/strong>\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Ober &amp; Yao, 2011\uff09\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u4e21\u89aa\u306e\u3069\u3061\u3089\u304b\u304c\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u6301\u3063\u3066\u3044\u308b\u5834\u5408\u3001<strong>\u5b50\u3069\u3082\u304c\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u306f\u7d042\u500d<\/strong>\u306b\u306a\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e21\u89aa\u3068\u3082\u306b\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u6301\u3064\u5834\u5408\u3001\u305d\u306e\u30ea\u30b9\u30af\u306f\u3055\u3089\u306b\u9ad8\u307e\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) \u4e3b\u8981\u306a\u30a2\u30ec\u30eb\u30ae\u30fc\u95a2\u9023\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u89e3\u6790\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u767a\u75c7\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u304c\u3044\u304f\u3064\u304b\u7279\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001<strong>IL-4R\u3001FLG\u3001HLA-DQ<\/strong> \u306a\u3069\u306e\u907a\u4f1d\u5b50\u304c\u30a2\u30ec\u30eb\u30ae\u30fc\u30ea\u30b9\u30af\u3068\u5f37\u304f\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IL-4R\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f34\u53d7\u5bb9\u4f53\u907a\u4f1d\u5b50\uff09<\/strong>\uff1a\u6c17\u7ba1\u652f\u5598\u606f\u3084\u82b1\u7c89\u75c7\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b<\/li>\n\n\n\n<li><strong>FLG\uff08\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u907a\u4f1d\u5b50\uff09<\/strong>\uff1a\u76ae\u819a\u30d0\u30ea\u30a2\u6a5f\u80fd\u306b\u95a2\u4e0e\u3057\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u767a\u75c7\u306b\u95a2\u9023<\/li>\n\n\n\n<li><strong>HLA-DQ\uff08\u30d2\u30c8\u767d\u8840\u7403\u6297\u539f\u907a\u4f1d\u5b50\uff09<\/strong>\uff1a\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u30ea\u30b9\u30af\u306b\u95a2\u4e0e<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u500b\u4eba\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u30ea\u30b9\u30af\u3092\u4e8b\u524d\u306b\u628a\u63e1\u3057\u3001\u9069\u5207\u306a\u4e88\u9632\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u304c\u53ef\u80fd<\/strong>\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u7ba1\u7406<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" data-id=\"5279\" src=\"\/gene\/wp-content\/uploads\/2025\/02\/31695239_m-1024x683.jpg\" alt=\"\" class=\"wp-image-5279\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31695239_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31695239_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31695239_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31695239_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31695239_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) \u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308b\u30ea\u30b9\u30af\u8a55\u4fa1<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u306f\u3001<strong>\u30a2\u30ec\u30eb\u30ae\u30fc\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306e\u591a\u578b\uff08SNP\uff09\u3092\u89e3\u6790<\/strong>\u3057\u3001\u500b\u4eba\u306e\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3057\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u60c5\u5831\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u95a2\u9023\u30a2\u30ec\u30eb\u30ae\u30fc<\/strong><\/td><td><strong>\u30ea\u30b9\u30af\u306e\u5f71\u97ff<\/strong><\/td><td><strong>\u63a8\u5968\u3055\u308c\u308b\u7ba1\u7406\u65b9\u6cd5<\/strong><\/td><\/tr><tr><td>IL-13<\/td><td>\u6c17\u7ba1\u652f\u5598\u606f<\/td><td>\u9ad8\u30ea\u30b9\u30af\u578b\u3067\u306f\u5598\u606f\u767a\u75c7\u7387\u304c\u4e0a\u6607<\/td><td>\u5ba4\u5185\u74b0\u5883\u306e\u6539\u5584\u3001\u5438\u5165\u30b9\u30c6\u30ed\u30a4\u30c9\u306e\u4f7f\u7528<\/td><\/tr><tr><td>FLG<\/td><td>\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e<\/td><td>\u76ae\u819a\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u4f4e\u4e0b<\/td><td>\u4fdd\u6e7f\u30b1\u30a2\u306e\u5fb9\u5e95\u3001\u4f4e\u523a\u6fc0\u6027\u30b9\u30ad\u30f3\u30b1\u30a2<\/td><\/tr><tr><td>HLA-DQ<\/td><td>\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc<\/td><td>\u514d\u75ab\u7cfb\u306e\u904e\u5270\u53cd\u5fdc<\/td><td>\u9664\u53bb\u98df\u306e\u5b9f\u8df5\u3001\u30a2\u30ec\u30eb\u30b2\u30f3\u514d\u75ab\u7642\u6cd5<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306a\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u75c7\u72b6\u304c\u51fa\u308b\u524d\u306b\u4e88\u9632\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u304c\u53ef\u80fd<\/strong>\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) \u500b\u5225\u6700\u9069\u5316\u3055\u308c\u305f\u4e88\u9632\u7b56\u306e\u5b9f\u8df5<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u3082\u3068\u306b\u3001<strong>\u500b\u3005\u306e\u4f53\u8cea\u306b\u5408\u308f\u305b\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u7ba1\u7406<\/strong>\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u5bfe\u7b56\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u2460 \u82b1\u7c89\u75c7\u30fb\u6c17\u7ba1\u652f\u5598\u606f\u306e\u7ba1\u7406\uff08IL-4R, IL-13\uff09<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7a7a\u6c17\u6e05\u6d44\u6a5f\u306e\u4f7f\u7528<\/strong>\uff1a\u82b1\u7c89\u3084\u30c0\u30cb\u306e\u30a2\u30ec\u30eb\u30b2\u30f3\u3092\u9664\u53bb<\/li>\n\n\n\n<li><strong>\u6297\u30d2\u30b9\u30bf\u30df\u30f3\u85ac\u3084\u5438\u5165\u30b9\u30c6\u30ed\u30a4\u30c9\u306e\u9069\u5207\u306a\u4f7f\u7528<\/strong><\/li>\n\n\n\n<li><strong>\u8178\u5185\u74b0\u5883\u306e\u6539\u5584\uff08\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u6442\u53d6\uff09<\/strong><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u2461 \u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u7ba1\u7406\uff08FLG\uff09<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4fdd\u6e7f\u3092\u5fb9\u5e95\u3057\u3001\u76ae\u819a\u30d0\u30ea\u30a2\u3092\u5f37\u5316<\/strong><\/li>\n\n\n\n<li><strong>\u4f4e\u523a\u6fc0\u6027\u306e\u30b9\u30ad\u30f3\u30b1\u30a2\u88fd\u54c1\u3092\u4f7f\u7528<\/strong><\/li>\n\n\n\n<li><strong>\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u3068\u306e\u95a2\u9023\u3092\u8003\u616e\u3057\u3001\u98df\u4e8b\u7ba1\u7406\u3092\u884c\u3046<\/strong><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u2462 \u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u7ba1\u7406\uff08HLA-DQ\uff09<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7279\u5b9a\u306e\u30a2\u30ec\u30eb\u30b2\u30f3\u3092\u907f\u3051\u308b\u98df\u4e8b\u8a08\u753b\u3092\u7b56\u5b9a<\/strong><\/li>\n\n\n\n<li><strong>\u533b\u5e2b\u3068\u76f8\u8ac7\u3057\u306a\u304c\u3089\u7d4c\u53e3\u514d\u75ab\u7642\u6cd5\uff08OIT\uff09\u3092\u691c\u8a0e<\/strong><\/li>\n\n\n\n<li><strong>\u91cd\u75c7\u306e\u5834\u5408\u3001\u30a8\u30d4\u30da\u30f3\uff08\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u81ea\u5df1\u6ce8\u5c04\u85ac\uff09\u3092\u5e38\u5099<\/strong><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u30a2\u30ec\u30eb\u30ae\u30fc\u3068\u74b0\u5883\u8981\u56e0\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/31179151_m-1-1024x683.jpg\" alt=\"\u3044\u308d\u3093\u306a\u8272\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\" class=\"wp-image-4707\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31179151_m-1-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31179151_m-1-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31179151_m-1-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31179151_m-1-1536x1025.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31179151_m-1.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u3060\u3051\u3067\u306a\u304f\u3001<strong>\u74b0\u5883\u8981\u56e0\u3082\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u767a\u75c7\u3084\u60aa\u5316\u306b\u5f71\u97ff<\/strong>\u3092\u4e0e\u3048\u307e\u3059\u3002\u907a\u4f1d\u5b50\u60c5\u5831\u3068\u74b0\u5883\u8981\u56e0\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u7ba1\u7406\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u75c7\u72b6\u8efd\u6e1b\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8178\u5185\u7d30\u83cc\u53e2\uff08\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\uff09<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7279\u5b9a\u306e\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\u3001L. \u30ed\u30a4\u30c6\u30ea\uff09\u304c\u30a2\u30ec\u30eb\u30ae\u30fc\u75c7\u72b6\u3092\u8efd\u6e1b<\/li>\n\n\n\n<li>\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u6574\u3048\u308b\u3053\u3068\u3067\u3001\u514d\u75ab\u7cfb\u306e\u904e\u5270\u53cd\u5fdc\u3092\u6291\u5236<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u74b0\u5883\u8981\u56e0\u306e\u8abf\u6574<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u5ba4\u5185\u306e\u30c0\u30cb\u30fb\u30ab\u30d3\u306e\u7ba1\u7406\uff08\u6383\u9664\u30fb\u63db\u6c17\u306e\u5fb9\u5e95\uff09<\/li>\n\n\n\n<li>\u4e73\u5150\u671f\u306e\u30da\u30c3\u30c8\u98fc\u80b2\u304c\u5598\u606f\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u53ef\u80fd\u6027\uff08Lodge et al., 2012\uff09<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u8981\u7d20\u3092\u8003\u616e\u3057\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3068\u74b0\u5883\u8981\u56e0\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u53d6\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u306e\u6700\u524d\u7dda<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u306e\u767a\u5c55\u306b\u3088\u308a\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u306e\u6cbb\u7642\u6cd5\u3082\u5927\u304d\u304f\u9032\u5316\u3057\u3066\u3044\u307e\u3059\u3002\u5f93\u6765\u306e\u5bfe\u75c7\u7642\u6cd5\u306b\u52a0\u3048\u3001<strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u6700\u9069\u5316\u6cbb\u7642<\/strong>\u304c\u53ef\u80fd\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) \u30d0\u30a4\u30aa\u533b\u85ac\u54c1\u3068\u907a\u4f1d\u5b50\u60c5\u5831<\/strong><\/h4>\n\n\n\n<p>\u8fd1\u5e74\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u306b\u304a\u3044\u3066\u30d0\u30a4\u30aa\u533b\u85ac\u54c1\u306e\u5229\u7528\u304c\u5897\u3048\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u85ac\u5264\u306f\u3001\u7279\u5b9a\u306e\u514d\u75ab\u53cd\u5fdc\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u3067\u75c7\u72b6\u3092\u8efd\u6e1b\u3057\u307e\u3059\u304c\u3001<strong>\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u52b9\u679c\u306e\u500b\u4eba\u5dee\u304c\u3042\u308b<\/strong>\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u30d0\u30a4\u30aa\u533b\u85ac\u54c1<\/strong><\/td><td><strong>\u9069\u5fdc\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3<\/strong><\/td><td><strong>\u4f5c\u7528\u6a5f\u5e8f<\/strong><\/td><td><strong>\u95a2\u9023\u907a\u4f1d\u5b50<\/strong><\/td><\/tr><tr><td>\u30c7\u30e5\u30d4\u30eb\u30de\u30d6\uff08Dupilumab\uff09<\/td><td>\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3001\u5598\u606f<\/td><td>IL-4, IL-13\u306e\u30b7\u30b0\u30ca\u30eb\u6291\u5236<\/td><td>IL4R<\/td><\/tr><tr><td>\u30aa\u30de\u30ea\u30ba\u30de\u30d6\uff08Omalizumab\uff09<\/td><td>\u91cd\u75c7\u5598\u606f\u3001\u6162\u6027\u8541\u9ebb\u75b9<\/td><td>IgE\u306e\u963b\u5bb3<\/td><td>FCER1A<\/td><\/tr><tr><td>\u30e1\u30dd\u30ea\u30ba\u30de\u30d6\uff08Mepolizumab\uff09<\/td><td>\u597d\u9178\u7403\u6027\u5598\u606f<\/td><td>IL-5\u306e\u963b\u5bb3<\/td><td>IL5<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u3069\u306e\u30d0\u30a4\u30aa\u533b\u85ac\u54c1\u304c\u6700\u3082\u52b9\u679c\u7684\u304b\u3092\u4e8b\u524d\u306b\u4e88\u6e2c\u3057\u3001\u500b\u5225\u5316\u6cbb\u7642\u3092\u5b9f\u73fe\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd<\/strong>\u3067\u3059\uff08Wechsler et al., 2019\uff09\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(2) \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\uff08CRISPR-Cas9\uff09\u3068\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642<\/strong><\/h4>\n\n\n\n<p>CRISPR-Cas9\u6280\u8853\u306e\u767a\u5c55\u306b\u3088\u308a\u3001<strong>\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u306e\u6839\u672c\u6cbb\u7642<\/strong>\u306e\u53ef\u80fd\u6027\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001<strong>IL-4R\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u5909\u7570\u3092\u4fee\u6b63\u3059\u308b\u3053\u3068\u3067\u3001\u5598\u606f\u3084\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u8a66\u307f<\/strong>\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\uff08Plaschkes et al., 2021\uff09\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306b\u95a2\u3057\u3066\u3082\u3001<strong>HLA-DQ\u907a\u4f1d\u5b50\u306e\u6539\u5909\u306b\u3088\u308a\u514d\u75ab\u53cd\u5fdc\u3092\u8abf\u6574\u3059\u308b\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u308b\u53ef\u80fd\u6027<\/strong>\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u304c\u5b9f\u73fe\u3059\u308c\u3070\u3001\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u60a3\u8005\u306e\u751f\u6d3b\u306e\u8cea\u304c\u5927\u304d\u304f\u5411\u4e0a\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5. \u907a\u4f1d\u5b50\u60c5\u5831\u3068\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u6700\u9069\u5316<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308c\u3070\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u4e88\u9632\u30fb\u7ba1\u7406\u3059\u308b\u305f\u3081\u306e\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3082\u500b\u5225\u6700\u9069\u5316\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) \u6804\u990a\u3068\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u907a\u4f1d\u7684\u95a2\u4fc2<\/strong><\/h4>\n\n\n\n<p>\u30a2\u30ec\u30eb\u30ae\u30fc\u4f53\u8cea\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u304c\u5224\u660e\u3057\u305f\u3053\u3068\u3067\u3001<strong>\u98df\u4e8b\u306e\u5f71\u97ff\u3092\u3088\u308a\u7cbe\u5bc6\u306b\u7ba1\u7406\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd<\/strong>\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FADS1\u907a\u4f1d\u5b50\u5909\u7570\u3068\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u4ee3\u8b1d<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4e00\u90e8\u306e\u4eba\u306f\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3092\u52b9\u7387\u7684\u306b\u4ee3\u8b1d\u3067\u304d\u305a\u3001<strong>EPA\u3084DHA\u3092\u76f4\u63a5\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u6297\u708e\u75c7\u4f5c\u7528\u3092\u6700\u5927\u5316\u3067\u304d\u308b<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>HLA-DQ\u907a\u4f1d\u5b50\u3068\u30b0\u30eb\u30c6\u30f3\u611f\u53d7\u6027<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30b0\u30eb\u30c6\u30f3\u30a2\u30ec\u30eb\u30ae\u30fc\uff08\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\uff09\u3068\u5f37\u3044\u95a2\u9023\u304c\u3042\u308a\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u3063\u3066\u5c0f\u9ea6\u6442\u53d6\u306e\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3067\u304d\u308b<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>IL-10\u907a\u4f1d\u5b50\u3068\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u306e\u52b9\u679c<\/strong>\n<ul class=\"wp-block-list\">\n<li>IL-10\u306e\u6d3b\u6027\u304c\u4f4e\u3044\u4eba\u306f\u3001<strong>\u4e73\u9178\u83cc\u3084\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\u306e\u6442\u53d6\u3067\u514d\u75ab\u30d0\u30e9\u30f3\u30b9\u3092\u6574\u3048\u308b\u3068\u30a2\u30ec\u30eb\u30ae\u30fc\u75c7\u72b6\u304c\u8efd\u6e1b\u3057\u3084\u3059\u3044<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u98df\u4e8b\u6226\u7565\u3092\u8a2d\u8a08\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(2) \u74b0\u5883\u8981\u56e0\u306e\u6700\u9069\u5316<\/strong><\/h4>\n\n\n\n<p>\u30a2\u30ec\u30eb\u30ae\u30fc\u767a\u75c7\u306b\u306f\u74b0\u5883\u8981\u56e0\u3082\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u3069\u306e\u3088\u3046\u306a\u74b0\u5883\u8981\u56e0\u306b\u6ce8\u610f\u3059\u3079\u304d\u304b\u3092\u7279\u5b9a\u3057\u3001\u751f\u6d3b\u74b0\u5883\u3092\u6700\u9069\u5316\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd<\/strong>\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IL-33\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u30c0\u30cb\u30a2\u30ec\u30eb\u30ae\u30fc\u306b\u306a\u308a\u3084\u3059\u3044\u305f\u3081\u3001\u7a7a\u6c17\u6e05\u6d44\u6a5f\u3084\u9632\u30c0\u30cb\u5bdd\u5177\u3092\u7a4d\u6975\u7684\u306b\u6d3b\u7528<\/li>\n\n\n\n<li><strong>ORMDL3\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u30bf\u30d0\u30b3\u7159\u3084\u5927\u6c17\u6c5a\u67d3\u306b\u3088\u308b\u5598\u606f\u60aa\u5316\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u305f\u3081\u3001\u7a7a\u6c17\u306e\u8cea\u3092\u91cd\u8996\u3057\u305f\u751f\u6d3b\u74b0\u5883\u3065\u304f\u308a\u304c\u91cd\u8981<\/li>\n\n\n\n<li><strong>FLG\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u76ae\u819a\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u5f31\u3044\u305f\u3081\u3001\u4e7e\u71e5\u3092\u9632\u304e\u3001\u9ad8\u6e7f\u5ea6\u74b0\u5883\u3092\u7dad\u6301<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u672a\u6765\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u7ba1\u7406<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/25176625_m-1024x683.jpg\" alt=\"\" class=\"wp-image-5247\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/25176625_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/25176625_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/25176625_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/25176625_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/25176625_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u4eca\u5f8c\u3001\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u306e\u3055\u3089\u306a\u308b\u767a\u5c55\u306b\u3088\u308a\u3001<strong>\u3088\u308a\u7cbe\u5bc6\u3067\u500b\u5225\u5316\u3055\u308c\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u7ba1\u7406\u304c\u53ef\u80fd<\/strong>\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) AI\u3092\u6d3b\u7528\u3057\u305f\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u4e88\u9632\u7b56<\/strong><\/h4>\n\n\n\n<p>AI\u6280\u8853\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u907a\u4f1d\u5b50\u60c5\u5831\u30fb\u5065\u5eb7\u30c7\u30fc\u30bf\u30fb\u751f\u6d3b\u7fd2\u6163\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3057\u3001\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u30a2\u30ec\u30eb\u30ae\u30fc\u30ea\u30b9\u30af\u3092\u7ba1\u7406<\/strong>\u3067\u304d\u308b\u6642\u4ee3\u304c\u8fd1\u3065\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AI\u306b\u3088\u308b\u30ea\u30b9\u30af\u4e88\u6e2c<\/strong>\uff1a\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u691c\u67fb\u7d50\u679c\u3068\u74b0\u5883\u30c7\u30fc\u30bf\uff08\u6c17\u6e29\u3001\u82b1\u7c89\u98db\u6563\u91cf\u306a\u3069\uff09\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u3001\u500b\u5225\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u30ea\u30b9\u30af\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u8a55\u4fa1<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30b9\u30de\u30fc\u30c8\u30c7\u30d0\u30a4\u30b9\u3068\u306e\u9023\u643a<\/strong>\uff1a\n<ul class=\"wp-block-list\">\n<li>\u30a6\u30a7\u30a2\u30e9\u30d6\u30eb\u30c7\u30d0\u30a4\u30b9\u3092\u6d3b\u7528\u3057\u3001\u76ae\u819a\u306e\u6c34\u5206\u91cf\u3084\u5fc3\u62cd\u6570\u3092\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3057\u3001\u75c7\u72b6\u60aa\u5316\u306e\u5146\u5019\u3092\u691c\u51fa<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(2) \u907a\u4f1d\u5b50\u7de8\u96c6\u3068\u500b\u5225\u5316\u533b\u7642\u306e\u9032\u5316<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u6cbb\u7642\u304c\u3055\u3089\u306b\u9032\u5316\u3059\u308c\u3070\u3001<strong>\u30a2\u30ec\u30eb\u30ae\u30fc\u4f53\u8cea\u305d\u306e\u3082\u306e\u3092\u6839\u672c\u7684\u306b\u6539\u5584\u3059\u308b\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u308b\u53ef\u80fd\u6027<\/strong>\u304c\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001CRISPR-Cas9\u3092\u5229\u7528\u3057\u305f\u907a\u4f1d\u5b50\u4fee\u6b63\u306b\u3088\u308a\u3001<strong>\u514d\u75ab\u7cfb\u306e\u904e\u5270\u53cd\u5fdc\u3092\u6291\u5236\u3057\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u6839\u672c\u7684\u306b\u9632\u3050\u6cbb\u7642\u6cd5<\/strong>\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7. \u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u304f\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u500b\u5225\u6700\u9069\u5316\u7ba1\u7406<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u306e\u6d3b\u7528\u306b\u3088\u308a\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u7ba1\u7406\u65b9\u6cd5\u3092\u500b\u3005\u306e\u4f53\u8cea\u306b\u5408\u308f\u305b\u3066\u6700\u9069\u5316\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u3053\u3067\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u500b\u5225\u7ba1\u7406\u306b\u3064\u3044\u3066\u3001\u5177\u4f53\u7684\u306a\u624b\u9806\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u53d7\u8a3a\u3068\u7d50\u679c\u306e\u89e3\u91c8<\/strong><\/h4>\n\n\n\n<p>\u307e\u305a\u3001\u4fe1\u983c\u6027\u306e\u9ad8\u3044\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002\u30a2\u30ec\u30eb\u30ae\u30fc\u95a2\u9023\u306e\u907a\u4f1d\u5b50\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u60c5\u5831\u304c\u5f97\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u95a2\u9023\u30a2\u30ec\u30eb\u30ae\u30fc<\/strong><\/td><td><strong>\u5f71\u97ff\u306e\u7279\u5fb4<\/strong><\/td><td><strong>\u63a8\u5968\u3055\u308c\u308b\u7ba1\u7406\u7b56<\/strong><\/td><\/tr><tr><td>IL-4R<\/td><td>\u6c17\u7ba1\u652f\u5598\u606f\u30fb\u82b1\u7c89\u75c7<\/td><td>IL-4\u306e\u904e\u5270\u7523\u751f\u3067\u708e\u75c7\u304c\u5897\u52a0<\/td><td>\u6297\u30d2\u30b9\u30bf\u30df\u30f3\u85ac\u3084\u5438\u5165\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u6d3b\u7528<\/td><\/tr><tr><td>FLG<\/td><td>\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e<\/td><td>\u76ae\u819a\u30d0\u30ea\u30a2\u304c\u5f31\u304f\u4e7e\u71e5\u3057\u3084\u3059\u3044<\/td><td>\u4fdd\u6e7f\u30b1\u30a2\u3001\u6297\u708e\u75c7\u85ac\u306e\u5229\u7528<\/td><\/tr><tr><td>HLA-DQ<\/td><td>\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc<\/td><td>\u514d\u75ab\u7cfb\u306e\u904e\u5270\u53cd\u5fdc<\/td><td>\u9664\u53bb\u98df\u3001\u30a2\u30ec\u30eb\u30b2\u30f3\u514d\u75ab\u7642\u6cd5\u306e\u691c\u8a0e<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u691c\u67fb\u7d50\u679c\u3092\u3082\u3068\u306b\u3001\u533b\u5e2b\u3084\u5c02\u9580\u5bb6\u3068\u76f8\u8ac7\u3057\u306a\u304c\u3089\u3001\u500b\u5225\u6700\u9069\u5316\u3055\u308c\u305f\u7ba1\u7406\u30d7\u30e9\u30f3\u3092\u4f5c\u6210\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(2) \u30a2\u30ec\u30eb\u30ae\u30fc\u767a\u75c7\u30ea\u30b9\u30af\u306b\u5fdc\u3058\u305f\u4e88\u9632\u7b56\u306e\u5b9f\u65bd<\/strong><\/h4>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u2460 \u4f4e\u30ea\u30b9\u30af\u306e\u4eba\uff08\u4e88\u9632\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\uff09<\/strong><\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5065\u5eb7\u7684\u306a\u98df\u751f\u6d3b\u3092\u7dad\u6301\u3057\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u767a\u75c7\u3092\u9632\u3050<\/li>\n\n\n\n<li>\u751f\u6d3b\u74b0\u5883\u3092\u6574\u3048\u3001\u30a2\u30ec\u30eb\u30b2\u30f3\u306e\u5f71\u97ff\u3092\u6700\u5c0f\u9650\u306b\u3059\u308b<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u2461 \u9ad8\u30ea\u30b9\u30af\u306e\u4eba\uff08\u7a4d\u6975\u7684\u306a\u7ba1\u7406\uff09<\/strong><\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5b9a\u671f\u7684\u306a\u691c\u8a3a\u3092\u53d7\u3051\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75c7\u72b6\u306e\u767a\u75c7\u3092\u65e9\u671f\u306b\u628a\u63e1<\/li>\n\n\n\n<li>\u533b\u5e2b\u306e\u6307\u5c0e\u306e\u3082\u3068\u3001\u514d\u75ab\u7642\u6cd5\u3084\u9069\u5207\u306a\u85ac\u7269\u7642\u6cd5\u3092\u5b9f\u65bd<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u65b0\u3057\u3044\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u6cd5<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"576\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/25991796_m-1024x576.jpg\" alt=\"\" class=\"wp-image-5141\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/25991796_m-1024x576.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/25991796_m-300x169.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/25991796_m-768x432.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/25991796_m-1536x864.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/25991796_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u6700\u65b0\u306e\u7814\u7a76\u3067\u306f\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u306e\u65b0\u305f\u306a\u65b9\u6cd5\u3068\u3057\u3066\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) \u514d\u75ab\u7642\u6cd5\u3068\u907a\u4f1d\u5b50\u60c5\u5831\u306e\u6d3b\u7528<\/strong><\/h4>\n\n\n\n<p>**\u30a2\u30ec\u30eb\u30b2\u30f3\u514d\u75ab\u7642\u6cd5\uff08AIT\uff09**\u306f\u3001\u30a2\u30ec\u30eb\u30b2\u30f3\u3092\u5c11\u91cf\u305a\u3064\u6295\u4e0e\u3057\u3066\u514d\u75ab\u7cfb\u3092\u5f90\u3005\u306b\u9069\u5fdc\u3055\u305b\u308b\u6cbb\u7642\u6cd5\u3067\u3059\u3002\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u3069\u306e\u60a3\u8005\u306b\u514d\u75ab\u7642\u6cd5\u304c\u6700\u3082\u52b9\u679c\u7684\u304b\u3092\u4e8b\u524d\u306b\u4e88\u6e2c\u3059\u308b<\/strong>\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>HLA\u907a\u4f1d\u5b50\u306e\u591a\u578b\u306b\u3088\u3063\u3066\u3001\u514d\u75ab\u7642\u6cd5\u306e\u52b9\u679c\u306b\u500b\u4eba\u5dee\u304c\u3042\u308b\u3053\u3068\u304c\u5224\u660e<\/strong>\uff08Bousquet et al., 2020\uff09<\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u5b50\u89e3\u6790\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u3088\u308a\u9ad8\u3044\u6210\u529f\u7387\u304c\u671f\u5f85\u3067\u304d\u308b\u60a3\u8005\u3092\u7279\u5b9a<\/strong><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(2) \u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u3068\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u95a2\u4fc2<\/strong><\/h4>\n\n\n\n<p>\u8178\u5185\u7d30\u83cc\u53e2\uff08\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\uff09\u304c\u30a2\u30ec\u30eb\u30ae\u30fc\u767a\u75c7\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001<strong>\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u8178\u5185\u74b0\u5883\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u7570\u306a\u308a\u3001\u7279\u5b9a\u306e\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u304c\u6709\u52b9\u304b\u3069\u3046\u304b\u304c\u5909\u308f\u308b<\/strong>\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FUT2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong>\uff1a\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u30a2\u30ec\u30eb\u30ae\u30fc\u75c7\u72b6\u304c\u8efd\u6e1b\u3059\u308b\u53ef\u80fd\u6027<\/li>\n\n\n\n<li><strong>IL-10\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u304c\u4f4e\u3044\u4eba<\/strong>\uff1aL. \u30ed\u30a4\u30c6\u30ea\u83cc\u304c\u514d\u75ab\u8abf\u6574\u306b\u52b9\u679c\u7684<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u77e5\u898b\u3092\u6d3b\u7528\u3057\u3001<strong>\u500b\u3005\u306e\u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u306e\u9078\u629e\u304c\u53ef\u80fd\u306b\u306a\u308b\u672a\u6765<\/strong>\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u74b0\u5883\u7ba1\u7406\u3068\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u8abf\u6574<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306b\u74b0\u5883\u7ba1\u7406\u3092\u884c\u3046\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) \u4f4f\u74b0\u5883\u306e\u6700\u9069\u5316<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u7684\u306b\u7279\u5b9a\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u306b\u304b\u304b\u308a\u3084\u3059\u3044\u4eba\u306f\u3001\u751f\u6d3b\u74b0\u5883\u306e\u7ba1\u7406\u3092\u5fb9\u5e95\u3059\u308b\u3053\u3068\u3067\u75c7\u72b6\u3092\u8efd\u6e1b\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IL-33\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong>\uff1a\u30c0\u30cb\u3084\u30ab\u30d3\u306b\u3088\u308b\u30a2\u30ec\u30eb\u30ae\u30fc\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u305f\u3081\u3001\u7a7a\u6c17\u6e05\u6d44\u6a5f\u306e\u6d3b\u7528\u3084\u5b9a\u671f\u7684\u306a\u63db\u6c17\u3092\u63a8\u5968<\/li>\n\n\n\n<li><strong>ORMDL3\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong>\uff1a\u5927\u6c17\u6c5a\u67d3\u304c\u5598\u606f\u3092\u60aa\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001PM2.5\u5bfe\u7b56\u3092\u5f37\u5316<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(2) \u904b\u52d5\u7fd2\u6163\u306e\u6700\u9069\u5316<\/strong><\/h4>\n\n\n\n<p>\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u3092\u6301\u3064\u4eba\u306f\u3001\u907a\u4f1d\u7684\u306a\u8981\u56e0\u3092\u8003\u616e\u3057\u306a\u304c\u3089\u3001\u9069\u5207\u306a\u904b\u52d5\u3092\u884c\u3046\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6c17\u7ba1\u652f\u5598\u606f\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba<\/strong>\uff08IL-4R, IL-13\u5909\u7570\uff09\n<ul class=\"wp-block-list\">\n<li>\u904b\u52d5\u8a98\u767a\u6027\u5598\u606f\u3092\u9632\u3050\u305f\u3081\u3001\u30a6\u30a9\u30fc\u30e0\u30a2\u30c3\u30d7\u3092\u3057\u3063\u304b\u308a\u884c\u3046<\/li>\n\n\n\n<li>\u5c4b\u5185\u3067\u306e\u4f4e\u5f37\u5ea6\u904b\u52d5\uff08\u30e8\u30ac\u3001\u30b9\u30c8\u30ec\u30c3\u30c1\uff09\u304c\u63a8\u5968\u3055\u308c\u308b<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba<\/strong>\uff08FLG\u5909\u7570\uff09\n<ul class=\"wp-block-list\">\n<li>\u767a\u6c57\u306b\u3088\u308b\u75c7\u72b6\u60aa\u5316\u3092\u9632\u3050\u305f\u3081\u3001\u904b\u52d5\u5f8c\u306e\u30b7\u30e3\u30ef\u30fc\u3092\u5fb9\u5e95<\/li>\n\n\n\n<li>\u6c34\u6cf3\u306a\u3069\u306e\u4f4e\u523a\u6fc0\u306a\u904b\u52d5\u304c\u9069\u3057\u3066\u3044\u308b<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10. \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u672a\u6765\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u5bfe\u7b56<\/strong><\/h3>\n\n\n\n<p>\u4eca\u5f8c\u306e\u6280\u8853\u9769\u65b0\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u7ba1\u7406\u306f\u3055\u3089\u306b\u9ad8\u5ea6\u5316\u3057\u3066\u3044\u304f\u3053\u3068\u304c\u4e88\u60f3\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) AI\u3068\u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u306b\u3088\u308b\u4e88\u9632\u533b\u7642<\/strong><\/h4>\n\n\n\n<p>AI\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u7ba1\u7406\u304c\u9032\u5c55\u3057\u3001<strong>\u500b\u4eba\u306e\u907a\u4f1d\u60c5\u5831\u3001\u751f\u6d3b\u74b0\u5883\u30c7\u30fc\u30bf\u3001\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u306e\u5065\u5eb7\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3057\u3066\u30a2\u30ec\u30eb\u30ae\u30fc\u30ea\u30b9\u30af\u3092\u4e88\u6e2c<\/strong>\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3068\u30b9\u30de\u30fc\u30c8\u30c7\u30d0\u30a4\u30b9\u306e\u9023\u643a<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u76ae\u819a\u306e\u6e7f\u5ea6\u3084\u4f53\u6e29\u3092\u6e2c\u5b9a\u3057\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u60aa\u5316\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u691c\u51fa<\/li>\n\n\n\n<li>\u547c\u5438\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3057\u3001\u5598\u606f\u767a\u4f5c\u306e\u30ea\u30b9\u30af\u3092\u4e8b\u524d\u306b\u8b66\u544a<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(2) \u907a\u4f1d\u5b50\u7de8\u96c6\u306b\u3088\u308b\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u6839\u672c\u6cbb\u7642<\/strong><\/h4>\n\n\n\n<p>CRISPR-Cas9\u3092\u6d3b\u7528\u3057\u305f\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u304c\u9032\u5316\u3059\u308c\u3070\u3001<strong>\u30a2\u30ec\u30eb\u30ae\u30fc\u4f53\u8cea\u81ea\u4f53\u3092\u4fee\u6b63\u3059\u308b\u6cbb\u7642\u6cd5<\/strong>\u304c\u958b\u767a\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IL-4R\u907a\u4f1d\u5b50\u306e\u4fee\u6b63<\/strong>\u306b\u3088\u308a\u3001\u5598\u606f\u3084\u82b1\u7c89\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u5927\u5e45\u306b\u4f4e\u6e1b<\/li>\n\n\n\n<li><strong>HLA-DQ\u907a\u4f1d\u5b50\u306e\u6539\u5909<\/strong>\u3067\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u6839\u672c\u7684\u306a\u6cbb\u7642\u304c\u53ef\u80fd\u306b<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>11. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u306e\u672a\u6765<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/02\/31151287_m-1024x683.jpg\" alt=\"\" class=\"wp-image-5289\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31151287_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31151287_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31151287_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31151287_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31151287_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u57fa\u306b\u3057\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u7ba1\u7406\u306e\u6280\u8853\u306f\u6025\u901f\u306b\u767a\u5c55\u3057\u3066\u304a\u308a\u3001\u4eca\u5f8c\u306f\u3088\u308a\u500b\u5225\u6700\u9069\u5316\u3055\u308c\u305f\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/strong><\/h3>\n\n\n\n<h3 class=\"wp-block-heading\"><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) \u907a\u4f1d\u5b50\u30ef\u30af\u30c1\u30f3\u306b\u3088\u308b\u30a2\u30ec\u30eb\u30ae\u30fc\u4e88\u9632<\/strong><\/h4>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u5f93\u6765\u306e\u30a2\u30ec\u30eb\u30b2\u30f3\u514d\u75ab\u7642\u6cd5\uff08\u820c\u4e0b\u514d\u75ab\u7642\u6cd5\u3084\u76ae\u4e0b\u6ce8\u5c04\uff09\u306f\u3001\u9577\u671f\u9593\u306b\u308f\u305f\u308b\u6cbb\u7642\u304c\u5fc5\u8981\u3067\u3059\u304c\u3001\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306fDNA\u30ef\u30af\u30c1\u30f3\u3092\u7528\u3044\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u4e88\u9632\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IL-10\u3092\u8a98\u5c0e\u3059\u308b\u907a\u4f1d\u5b50\u30ef\u30af\u30c1\u30f3<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u6291\u5236\u3059\u308bIL-10\uff08\u6297\u708e\u75c7\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff09\u306e\u767a\u73fe\u3092\u4fc3\u9032<\/strong><\/li>\n\n\n\n<li><strong>\u82b1\u7c89\u75c7\u3084\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u4e88\u9632\u306b\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u308b<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>CRISPR\u30d9\u30fc\u30b9\u306e\u30ef\u30af\u30c1\u30f3<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>IL-4R\u907a\u4f1d\u5b50\u306e\u8abf\u6574\u306b\u3088\u308a\u3001\u5598\u606f\u3084\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u767a\u75c7\u3092\u6291\u5236<\/strong><\/li>\n\n\n\n<li><strong>HLA\u907a\u4f1d\u5b50\u306e\u6539\u5909\u306b\u3088\u308b\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u8efd\u6e1b<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u3053\u306e\u3088\u3046\u306a\u6280\u8853\u304c\u5b9f\u7528\u5316\u3055\u308c\u308c\u3070\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u306e\u767a\u75c7\u3092\u6839\u672c\u304b\u3089\u9632\u3050\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\uff08Akdis, 2021\uff09\u3002<\/strong><\/h3>\n\n\n\n<h3 class=\"wp-block-heading\"><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(2) \u907a\u4f1d\u5b50\u60c5\u5831\u3068\u30ca\u30ce\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u3092\u6d3b\u7528\u3057\u305f\u85ac\u5264\u958b\u767a<\/strong><\/h4>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30ca\u30ce\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u3092\u6d3b\u7528\u3057\u305f\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u907a\u4f1d\u5b50\u306b\u76f4\u63a5\u4f5c\u7528\u3059\u308bRNA\u6cbb\u7642\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>siRNA\uff08\u5c0f\u5e72\u6e09RNA\uff09\u3092\u5229\u7528\u3057\u305f\u6cbb\u7642<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>IL-4\u3001IL-5\u3001IL-13\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3057\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u6291\u5236<\/strong><\/li>\n\n\n\n<li><strong>\u76ae\u819a\u3084\u6c17\u9053\u306b\u76f4\u63a5\u9001\u9054\u3067\u304d\u308b\u30ca\u30ce\u7c92\u5b50\u6280\u8853\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u9ad8\u3044\u6cbb\u7642\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u308b<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>mRNA\u30ef\u30af\u30c1\u30f3\u6280\u8853\u306e\u5fdc\u7528<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u30ef\u30af\u30c1\u30f3\u306b\u7528\u3044\u3089\u308c\u305fmRNA\u6280\u8853\u3092\u6d3b\u7528\u3057\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6291\u5236\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7523\u751f\u3092\u4fc3\u9032<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u3053\u308c\u306b\u3088\u308a\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u6839\u672c\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u308b\u6642\u4ee3\u304c\u8fd1\u3065\u3044\u3066\u3044\u307e\u3059\uff08Zhang et al., 2022\uff09\u3002<\/strong><\/h3>\n\n\n\n<h3 class=\"wp-block-heading\"><\/h3>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u6b21\u4e16\u4ee3\u30a2\u30ec\u30eb\u30ae\u30fc\u8a3a\u65ad<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) \u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff08PRS\uff09\u3092\u7528\u3044\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u30ea\u30b9\u30af\u8a55\u4fa1<\/strong><\/h4>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u6700\u65b0\u306e\u907a\u4f1d\u5b50\u89e3\u6790\u3067\u306f\u3001\u8907\u6570\u306e\u907a\u4f1d\u5b50\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u300c\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff08PRS\uff09\u300d\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u7cbe\u5bc6\u306a\u30a2\u30ec\u30eb\u30ae\u30fc\u30ea\u30b9\u30af\u8a55\u4fa1\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PRS\u3092\u6d3b\u7528\u3057\u305f\u5598\u606f\u30ea\u30b9\u30af\u4e88\u6e2c<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u6570\u767e\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u89e3\u6790\u3057\u3001\u500b\u4eba\u306e\u5598\u606f\u767a\u75c7\u30ea\u30b9\u30af\u3092\u6570\u5024\u5316<\/strong><\/li>\n\n\n\n<li><strong>\u5c0f\u5150\u671f\u304b\u3089\u4e88\u9632\u7b56\u3092\u7acb\u3066\u308b\u3053\u3068\u3067\u3001\u767a\u75c7\u30ea\u30b9\u30af\u3092\u5927\u5e45\u306b\u4f4e\u6e1b<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u500b\u5225\u30ea\u30b9\u30af\u8a55\u4fa1<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>FLG\u3001IL-13\u3001TSLP \u306a\u3069\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u7d44\u307f\u5408\u308f\u305b\u305fPRS\u3092\u958b\u767a<\/strong><\/li>\n\n\n\n<li><strong>\u4e73\u5150\u671f\u304b\u3089\u9069\u5207\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u767a\u75c7\u3092\u6291\u3048\u308b<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>PRS\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u5358\u4e00\u907a\u4f1d\u5b50\u3067\u306f\u4e88\u6e2c\u3067\u304d\u306a\u304b\u3063\u305f\u30ea\u30b9\u30af\u3092\u7d71\u5408\u7684\u306b\u8a55\u4fa1\u3057\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u4e88\u9632\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\uff08Dijk et al., 2023\uff09\u3002<\/strong><\/h3>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(2) AI\u3092\u6d3b\u7528\u3057\u305f\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30a2\u30ec\u30eb\u30ae\u30fc\u8a3a\u65ad<\/strong><\/h4>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>AI\u6280\u8853\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3001\u74b0\u5883\u30c7\u30fc\u30bf\u3001\u5065\u5eb7\u8a3a\u65ad\u7d50\u679c\u3092\u7d71\u5408\u3057\u3001\u500b\u5225\u6700\u9069\u5316\u3055\u308c\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u7ba1\u7406\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AI\u306b\u3088\u308b\u82b1\u7c89\u75c7\u4e88\u6e2c\u30b7\u30b9\u30c6\u30e0<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u578b \u00d7 \u82b1\u7c89\u98db\u6563\u91cf \u00d7 \u5929\u6c17\u30c7\u30fc\u30bf \u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u3001\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u75c7\u72b6\u60aa\u5316\u30ea\u30b9\u30af\u3092\u4e88\u6e2c<\/strong><\/li>\n\n\n\n<li><strong>\u4e88\u6e2c\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u85ac\u306e\u670d\u7528\u30bf\u30a4\u30df\u30f3\u30b0\u3092\u63d0\u6848<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30b9\u30de\u30fc\u30c8\u30c7\u30d0\u30a4\u30b9\u3068\u306e\u9023\u643a<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u30b9\u30de\u30fc\u30c8\u30a6\u30a9\u30c3\u30c1\u3067\u76ae\u819a\u306e\u6c34\u5206\u91cf\u3001\u8840\u4e2d\u9178\u7d20\u6fc3\u5ea6\u3092\u6e2c\u5b9a\u3057\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u767a\u75c7\u30ea\u30b9\u30af\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0<\/strong><\/li>\n\n\n\n<li><strong>AI\u304c\u500b\u5225\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u5bfe\u7b56\u3092\u63d0\u6848\u3057\u3001\u75c7\u72b6\u3092\u4e8b\u524d\u306b\u7ba1\u7406<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u3053\u308c\u306b\u3088\u308a\u3001\u500b\u5225\u6700\u9069\u5316\u3055\u308c\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u4e88\u9632\u304c\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u884c\u3048\u308b\u6642\u4ee3\u304c\u8a2a\u308c\u3088\u3046\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/strong><\/h3>\n\n\n\n<h3 class=\"wp-block-heading\"><\/h3>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>13. \u907a\u4f1d\u5b50\u60c5\u5831\u3068\u74b0\u5883\u8981\u56e0\u306e\u7d71\u5408\u7684\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong><\/h3>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u767a\u75c7\u306b\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3060\u3051\u3067\u306a\u304f\u3001\u74b0\u5883\u8981\u56e0\u3082\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u6700\u65b0\u306e\u7814\u7a76\u3067\u306f\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3068\u74b0\u5883\u8981\u56e0\u3092\u7d71\u5408\u7684\u306b\u89e3\u6790\u3057\u3001\u6700\u9069\u306a\u751f\u6d3b\u74b0\u5883\u3092\u63d0\u6848\u3059\u308b\u30b7\u30b9\u30c6\u30e0\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/3624176_m-1024x683.jpg\" alt=\"\" class=\"wp-image-5148\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/3624176_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/3624176_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/3624176_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/3624176_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/3624176_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) \u74b0\u5883\u8981\u56e0\u3068\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u7ba1\u7406\u6cd5<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8178\u5185\u7d30\u83cc\u53e2\uff08\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\uff09\u3068\u30a2\u30ec\u30eb\u30ae\u30fc<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u578b\u306b\u3088\u3063\u3066\u3001\u7279\u5b9a\u306e\u8178\u5185\u7d30\u83cc\u304c\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u767a\u75c7\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u5224\u660e<\/strong><\/li>\n\n\n\n<li><strong>\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08L.\u30ed\u30a4\u30c6\u30ea\u83cc\u3001B.\u30d3\u30d5\u30a3\u30c0\u30e0\uff09\u306e\u6442\u53d6\u304c\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u578b\u3067\u6709\u52b9<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u98df\u4e8b\u3068\u907a\u4f1d\u5b50\u306e\u76f8\u4e92\u4f5c\u7528<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>FADS1\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u4eba\u306f\u3001EPA\u3084DHA\u306e\u6442\u53d6\u91cf\u3092\u5897\u3084\u3059\u3053\u3068\u3067\u708e\u75c7\u3092\u6291\u5236<\/strong><\/li>\n\n\n\n<li><strong>HLA-DQ\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u5c0f\u9ea6\u6442\u53d6\u3092\u63a7\u3048\u308b\u3053\u3068\u3067\u30a2\u30ec\u30eb\u30ae\u30fc\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u5ba4\u5185\u74b0\u5883\u306e\u7ba1\u7406<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>IL-33\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u7a7a\u6c17\u6e05\u6d44\u6a5f\u3084\u9664\u6e7f\u6a5f\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u30c0\u30cb\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u75c7\u72b6\u3092\u8efd\u6e1b<\/strong><\/li>\n\n\n\n<li><strong>ORMDL3\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u4eba\u306f\u3001\u5927\u6c17\u6c5a\u67d3\u5bfe\u7b56\u3092\u5f37\u5316\u3057\u3001\u5598\u606f\u30ea\u30b9\u30af\u3092\u6291\u3048\u308b<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>14. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30bb\u30eb\u30d5\u30b1\u30a2\u306e\u5b9f\u8df5\u30ac\u30a4\u30c9<\/strong><\/h3>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u7d50\u679c\u3092\u65e5\u5e38\u751f\u6d3b\u306b\u6d3b\u304b\u3057\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75c7\u72b6\u3092\u7ba1\u7406\u3059\u308b\u305f\u3081\u306e\u5177\u4f53\u7684\u306a\u30bb\u30eb\u30d5\u30b1\u30a2\u65b9\u6cd5\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/strong><\/h3>\n\n\n\n<h3 class=\"wp-block-heading\"><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) \u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u98df\u4e8b\u306e\u6700\u9069\u5316<\/strong><\/h4>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u306b\u5fdc\u3058\u305f\u98df\u4e8b\u8abf\u6574\u306f\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u767a\u75c7\u3084\u60aa\u5316\u3092\u9632\u3050\u91cd\u8981\u306a\u624b\u6bb5\u3067\u3059\u3002<\/strong><\/h3>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u2460 \u6297\u708e\u75c7\u4f5c\u7528\u306e\u3042\u308b\u98df\u54c1\u3092\u6442\u53d6<\/strong><\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IL-13\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u6c17\u9053\u306e\u708e\u75c7\u304c\u8d77\u3053\u308a\u3084\u3059\u3044\u305f\u3081\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff08\u30b5\u30fc\u30e2\u30f3\u3001\u30c1\u30a2\u30b7\u30fc\u30c9\uff09 \u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6<\/strong><\/li>\n\n\n\n<li><strong>\u6297\u9178\u5316\u4f5c\u7528\u306e\u9ad8\u3044\u98df\u54c1\uff08\u30d6\u30eb\u30fc\u30d9\u30ea\u30fc\u3001\u7dd1\u8336\uff09\u304c\u6709\u52b9<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>FLG\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u76ae\u819a\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u305f\u3081\u3001\u30d3\u30bf\u30df\u30f3E\uff08\u30a2\u30dc\u30ab\u30c9\u3001\u30ca\u30c3\u30c4\u985e\uff09\u3084\u30bb\u30e9\u30df\u30c9\uff08\u7384\u7c73\u3001\u5c0f\u9ea6\u80da\u82bd\uff09 \u3092\u88dc\u7d66<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u2461 \u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u30ea\u30b9\u30af\u3092\u8003\u616e\u3057\u305f\u98df\u4e8b\u5236\u9650<\/strong><\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>HLA-DQ\u907a\u4f1d\u5b50\u306e\u5f71\u97ff\u3092\u53d7\u3051\u308b\u4eba\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u5c0f\u9ea6\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u305f\u3081\u3001\u30b0\u30eb\u30c6\u30f3\u30d5\u30ea\u30fc\u306e\u98df\u4e8b\u304c\u6709\u52b9<\/strong><\/li>\n\n\n\n<li><strong>\u4ee3\u66ff\u98df\u54c1\u3068\u3057\u3066\u3001\u30ad\u30cc\u30a2\u3084\u30bd\u30d0\u3092\u6d3b\u7528<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(2) \u74b0\u5883\u5bfe\u7b56\u3068\u751f\u6d3b\u7fd2\u6163\u306e\u6700\u9069\u5316<\/strong><\/h4>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u2460 \u30a2\u30ec\u30eb\u30b2\u30f3\u306e\u7ba1\u7406<\/strong><\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IL-33\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u4eba\uff08\u30c0\u30cb\u30fb\u30db\u30b3\u30ea\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\uff09\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u6027\u80fdHEPA\u30d5\u30a3\u30eb\u30bf\u30fc\u4ed8\u304d\u306e\u7a7a\u6c17\u6e05\u6d44\u6a5f\u3092\u4f7f\u7528<\/strong><\/li>\n\n\n\n<li><strong>\u5e03\u56e3\u3084\u30ab\u30fc\u30da\u30c3\u30c8\u3092\u983b\u7e41\u306b\u6d17\u6fef\u3057\u3001\u9632\u30c0\u30cb\u30ab\u30d0\u30fc\u3092\u6d3b\u7528<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>ORMDL3\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u4eba\uff08\u5927\u6c17\u6c5a\u67d3\u3084PM2.5\u306b\u654f\u611f\uff09\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u7a93\u3092\u9589\u3081\u3001\u5ba4\u5185\u7a7a\u6c17\u3092\u6d44\u5316\u3059\u308b\u305f\u3081\u306b\u690d\u7269\uff08\u30b5\u30f3\u30b9\u30d9\u30ea\u30a2\u3001\u30dd\u30c8\u30b9\uff09\u3092\u914d\u7f6e<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u2461 \u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u3068\u514d\u75ab\u8abf\u6574<\/strong><\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>BDNF\u907a\u4f1d\u5b50\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u4eba\uff08\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u708e\u75c7\u60aa\u5316\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\uff09\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u7791\u60f3\u3084\u30de\u30a4\u30f3\u30c9\u30d5\u30eb\u30cd\u30b9\u3092\u5b9f\u8df5\u3057\u3001\u81ea\u5f8b\u795e\u7d4c\u3092\u6574\u3048\u308b<\/strong><\/li>\n\n\n\n<li><strong>\u30e8\u30ac\u3084\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0\u3092\u53d6\u308a\u5165\u308c\u3001\u30b9\u30c8\u30ec\u30b9\u8efd\u6e1b\u3092\u56f3\u308b<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><\/h3>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>15. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u672a\u6765\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u4e88\u9632\u6226\u7565<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"768\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/31878771_m-1024x768.jpg\" alt=\"\" class=\"wp-image-5300\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31878771_m-1024x768.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31878771_m-300x225.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31878771_m-768x576.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31878771_m-1536x1152.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31878771_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u4eca\u5f8c\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u306e\u6d3b\u7528\u304c\u3055\u3089\u306b\u9032\u3080\u3053\u3068\u3067\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u7ba1\u7406\u306e\u9078\u629e\u80a2\u304c\u5e83\u304c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306b\u3088\u308b\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u6839\u6cbb\u7642\u6cd5\u306e\u958b\u767a<\/strong><\/li>\n\n\n\n<li><strong>AI\u3068\u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u305f\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u5065\u5eb7\u7ba1\u7406\u30b7\u30b9\u30c6\u30e0\u306e\u666e\u53ca<\/strong><\/li>\n\n\n\n<li><strong>\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u533b\u7642\u306b\u3088\u308b\u3001\u500b\u3005\u306e\u30ea\u30b9\u30af\u306b\u6700\u9069\u5316\u3055\u308c\u305f\u6cbb\u7642\u6cd5\u306e\u63d0\u4f9b<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><\/h3>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u4e88\u9632\u30fb\u7ba1\u7406\u306f\u3088\u308a\u7cbe\u5bc6\u304b\u3064\u500b\u5225\u5316\u3055\u308c\u305f\u3082\u306e\u3068\u306a\u308a\u3001\u79c1\u305f\u3061\u306e\u751f\u6d3b\u306e\u8cea\u3092\u5927\u5e45\u306b\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/strong><\/h3>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u307e\u3068\u3081<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4e8b\u524d\u306b\u8a55\u4fa1\u3057\u3001\u500b\u5225\u6700\u9069\u5316\u3055\u308c\u305f\u4e88\u9632\u30fb\u7ba1\u7406\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<strong>IL-4R\u3001FLG\u3001HLA-DQ<\/strong> 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