{"id":691,"date":"2024-12-06T01:58:58","date_gmt":"2024-12-06T01:58:58","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=691"},"modified":"2025-02-14T02:06:56","modified_gmt":"2025-02-14T02:06:56","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e6%83%85%e5%a0%b1%e3%81%a8%e6%8c%81%e4%b9%85%e5%8a%9b%e3%81%ab%e5%9f%ba%e3%81%a5%e3%81%84%e3%81%9f%e3%83%88%e3%83%ac%e3%83%bc%e3%83%8b%e3%83%b3%e3%82%b0%e6%b3%95","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e6%83%85%e5%a0%b1%e3%81%a8%e6%8c%81%e4%b9%85%e5%8a%9b%e3%81%ab%e5%9f%ba%e3%81%a5%e3%81%84%e3%81%9f%e3%83%88%e3%83%ac%e3%83%bc%e3%83%8b%e3%83%b3%e3%82%b0%e6%b3%95\/","title":{"rendered":"\u907a\u4f1d\u5b50\u60c5\u5831\u3068\u6301\u4e45\u529b\u306b\u57fa\u3065\u3044\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6cd5"},"content":{"rendered":"\n<p><strong>\u8fd1\u5e74\u3001\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u3068\u907a\u4f1d\u5b66\u306e\u878d\u5408\u304c\u9032\u307f\u3001\u500b\u3005\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u57fa\u306b\u3057\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u65b9\u6cd5\u306e\u7814\u7a76\u304c\u76db\u3093\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u6301\u4e45\u529b\u306f\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u306e\u4e21\u65b9\u306b\u3088\u3063\u3066\u6c7a\u5b9a\u3055\u308c\u307e\u3059\u304c\u3001\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u306e\u767a\u5c55\u306b\u3088\u308a\u3001\u6301\u4e45\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u6301\u4e45\u529b\u5411\u4e0a\u306b\u95a2\u4e0e\u3059\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50\u3068\u3001\u305d\u308c\u306b\u57fa\u3065\u304f\u6700\u9069\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6cd5\u306b\u3064\u3044\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>1. \u6301\u4e45\u529b\u3068\u907a\u4f1d\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p><strong>\u6301\u4e45\u529b\u3068\u306f\u3001\u9577\u6642\u9593\u306b\u308f\u305f\u3063\u3066\u904b\u52d5\u3092\u7d9a\u3051\u308b\u80fd\u529b\u306e\u3053\u3068\u3067\u3042\u308a\u3001\u6709\u9178\u7d20\u80fd\u529b\u3084\u7b4b\u6301\u4e45\u529b\u304c\u95a2\u4fc2\u3057\u307e\u3059\u3002\u6301\u4e45\u529b\u306e\u6307\u6a19\u3068\u3057\u3066\u6700\u3082\u3088\u304f\u7528\u3044\u3089\u308c\u308b\u306e\u304c**\u6700\u5927\u9178\u7d20\u6442\u53d6\u91cf\uff08VO2max\uff09**\u3067\u3059\u3002\u7814\u7a76\u306b\u3088\u308b\u3068\u3001VO2max\u306e\u7d0450%\u306f\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u6c7a\u307e\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08Bouchard et al., 1999\uff09\u3002\u307e\u305f\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306b\u5bfe\u3059\u308b\u9069\u5fdc\u306e\u5ea6\u5408\u3044\u306b\u3082\u907a\u4f1d\u7684\u306a\u9055\u3044\u304c\u3042\u308a\u3001\u540c\u3058\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3063\u3066\u3082\u500b\u4eba\u5dee\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u89e3\u6790\u306e\u7d50\u679c\u3001\u6301\u4e45\u529b\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u304c\u3044\u304f\u3064\u304b\u7279\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306bACTN3\u3001ACE\u3001PPARGC1A\u3068\u3044\u3063\u305f\u907a\u4f1d\u5b50\u304c\u6301\u4e45\u529b\u5411\u4e0a\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. \u6301\u4e45\u529b\u306b\u95a2\u9023\u3059\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"724\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/2469831_m-1024x724.jpg\" alt=\"\" class=\"wp-image-5113\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/2469831_m-1024x724.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/2469831_m-300x212.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/2469831_m-768x543.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/2469831_m-1536x1086.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/2469831_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) ACTN3\u907a\u4f1d\u5b50 \u2013 \u901f\u7b4b\u30fb\u9045\u7b4b\u306e\u7279\u6027\u306b\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<p><strong>ACTN3\uff08\u03b1-\u30a2\u30af\u30c1\u30cb\u30f3-3\uff09\u306f\u3001\u901f\u7b4b\u7dda\u7dad\u306b\u591a\u304f\u542b\u307e\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306b\u306f\u300cRR\u578b\u300d\u300cRX\u578b\u300d\u300cXX\u578b\u300d\u306e3\u7a2e\u985e\u304c\u3042\u308a\u3001\u7279\u306bXX\u578b\u306e\u4eba\u306f\u901f\u7b4b\u7dda\u7dad\u304c\u767a\u9054\u3057\u306b\u304f\u304f\u3001\u6301\u4e45\u7cfb\u30b9\u30dd\u30fc\u30c4\u306b\u9069\u3057\u3066\u3044\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08Yang et al., 2003\uff09\u3002<\/strong><\/p>\n\n\n\n<p><strong>ACTN3\u907a\u4f1d\u5b50\u578b\u5225\u306e\u7279\u5fb4\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>RR\u578b\u30fbRX\u578b\uff1a\u901f\u7b4b\u7dda\u7dad\u304c\u767a\u9054\u3057\u3084\u3059\u304f\u3001\u77ed\u8ddd\u96e2\u8d70\u3084\u30d1\u30ef\u30fc\u7cfb\u7af6\u6280\u306b\u5411\u3044\u3066\u3044\u308b<\/strong><\/li>\n\n\n\n<li><strong>XX\u578b\uff1a\u6301\u4e45\u529b\u5411\u4e0a\u306b\u9069\u3057\u305f\u7b4b\u7dda\u7dad\u69cb\u6210\u3092\u6301\u3061\u3001\u9577\u8ddd\u96e2\u8d70\u3084\u30de\u30e9\u30bd\u30f3\u306a\u3069\u306b\u5411\u3044\u3066\u3044\u308b<\/strong><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>ACTN3\u306b\u57fa\u3065\u304f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6cd5<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>XX\u578b\u306e\u4eba\uff1a\u9577\u6642\u9593\u306e\u4f4e\u5f37\u5ea6\u6709\u9178\u7d20\u904b\u52d5\uff08LSD\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff09\u3001\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong><\/li>\n\n\n\n<li><strong>RR\u578b\u30fbRX\u578b\u306e\u4eba\uff1a\u77ed\u6642\u9593\u9ad8\u5f37\u5ea6\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08HIIT\uff09\u3001\u30b9\u30d7\u30ea\u30f3\u30c8\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb<\/strong><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) ACE\u907a\u4f1d\u5b50 \u2013 \u8840\u5727\u8abf\u7bc0\u3068\u6301\u4e45\u529b\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p><strong>**ACE\uff08\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d20\uff09\u306f\u8840\u5727\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3001\u7b4b\u6301\u4e45\u529b\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u907a\u4f1d\u5b50\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306b\u306fI\u578b\uff08\u633f\u5165\u578b\uff09\u3068D\u578b\uff08\u6b20\u5931\u578b\uff09**\u304c\u3042\u308a\u3001\u6301\u4e45\u529b\u5411\u4e0a\u306b\u95a2\u3057\u3066\u306fI\u578b\u306e\u307b\u3046\u304c\u6709\u5229\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08Montgomery et al., 1998\uff09\u3002<\/strong><\/p>\n\n\n\n<p><strong>ACE\u907a\u4f1d\u5b50\u578b\u5225\u306e\u7279\u5fb4\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>II\u578b\uff08I\/I\uff09\uff1a\u6301\u4e45\u529b\u5411\u4e0a\u306b\u9069\u3057\u3001\u9577\u8ddd\u96e2\u8d70\u3084\u767b\u5c71\u306a\u3069\u306b\u5411\u3044\u3066\u3044\u308b<\/strong><\/li>\n\n\n\n<li><strong>ID\u578b\uff08I\/D\uff09\uff1a\u6301\u4e45\u529b\u3068\u30d1\u30ef\u30fc\u306e\u30d0\u30e9\u30f3\u30b9\u578b<\/strong><\/li>\n\n\n\n<li><strong>DD\u578b\uff08D\/D\uff09\uff1a\u77ed\u8ddd\u96e2\u8d70\u3084\u30d1\u30ef\u30fc\u7cfb\u7af6\u6280\u306b\u9069\u3057\u3066\u3044\u308b<\/strong><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>ACE\u306b\u57fa\u3065\u304f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6cd5<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>II\u578b\u306e\u4eba\uff1a\u4f4e\u5f37\u5ea6\u30fb\u9577\u6642\u9593\u306e\u6709\u9178\u7d20\u904b\u52d5<\/strong><\/li>\n\n\n\n<li><strong>DD\u578b\u306e\u4eba\uff1a\u7121\u9178\u7d20\u904b\u52d5\u3084\u77ed\u8ddd\u96e2\u30b9\u30d7\u30ea\u30f3\u30c8\u3092\u542b\u3081\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong><\/li>\n\n\n\n<li><strong>ID\u578b\u306e\u4eba\uff1a\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30d7\u30ed\u30b0\u30e9\u30e0<\/strong><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(3) PPARGC1A\u907a\u4f1d\u5b50 \u2013 \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u50cd\u304d\u3068\u6301\u4e45\u529b<\/strong><\/h3>\n\n\n\n<p><strong>**PPARGC1A\uff08PGC-1\u03b1\uff09**\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u751f\u6210\u3092\u4fc3\u9032\u3057\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u5411\u4e0a\u3055\u305b\u308b\u907a\u4f1d\u5b50\u3067\u3059\u3002\u6301\u4e45\u7cfb\u30a2\u30b9\u30ea\u30fc\u30c8\u306ePPARGC1A\u907a\u4f1d\u5b50\u306b\u306f\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u304c\u591a\u304f\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Eynon et al., 2011\uff09\u3002<\/strong><\/p>\n\n\n\n<p><strong>PPARGC1A\u306e\u7279\u5fb4\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5897\u52a0\u3092\u4fc3\u3057\u3001\u6301\u4e45\u529b\u306e\u5411\u4e0a\u306b\u5bc4\u4e0e<\/strong><\/li>\n\n\n\n<li><strong>\u6709\u9178\u7d20\u4ee3\u8b1d\u3092\u5f37\u5316\u3057\u3001\u75b2\u52b4\u306e\u84c4\u7a4d\u3092\u6291\u3048\u308b<\/strong><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>PPARGC1A\u306b\u57fa\u3065\u304f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6cd5<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u5897\u3084\u3059\u305f\u3081\u306e\u4f4e\u5f37\u5ea6\u9577\u6642\u9593\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08\u30be\u30fc\u30f32\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306b\u3088\u308b\u6301\u4e45\u529b\u5f37\u5316<\/strong><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u6700\u9069\u5316\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"684\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/31381746_m-1024x684.jpg\" alt=\"\u7b4b\u30c8\u30ec\" class=\"wp-image-3012\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31381746_m-1024x684.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31381746_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31381746_m-768x513.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31381746_m-1536x1026.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31381746_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><strong>\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u3005\u306e\u7279\u6027\u306b\u9069\u3057\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u8a2d\u8a08\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u4e00\u822c\u7684\u306a\u6301\u4e45\u529b\u5411\u4e0a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3068\u3001\u907a\u4f1d\u5b50\u306b\u57fa\u3065\u3044\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u65b9\u6cd5\u3092\u6bd4\u8f03\u3059\u308b\u3068\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u578b<\/strong><\/td><td><strong>\u63a8\u5968\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6cd5<\/strong><\/td><\/tr><tr><td><strong>ACTN3<\/strong><\/td><td><strong>XX<\/strong><\/td><td><strong>\u9577\u8ddd\u96e2\u30e9\u30f3\u30cb\u30f3\u30b0\u3001\u4f4e\u5f37\u5ea6\u6709\u9178\u7d20\u904b\u52d5<\/strong><\/td><\/tr><tr><td><strong>ACTN3<\/strong><\/td><td><strong>RR\/RX<\/strong><\/td><td><strong>HIIT\u3001\u30b9\u30d7\u30ea\u30f3\u30c8\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong><\/td><\/tr><tr><td><strong>ACE<\/strong><\/td><td><strong>II<\/strong><\/td><td><strong>\u9577\u6642\u9593\u306e\u6709\u9178\u7d20\u904b\u52d5\uff08\u30de\u30e9\u30bd\u30f3\u3001\u767b\u5c71\uff09<\/strong><\/td><\/tr><tr><td><strong>ACE<\/strong><\/td><td><strong>DD<\/strong><\/td><td><strong>\u77ed\u6642\u9593\u9ad8\u5f37\u5ea6\u904b\u52d5\uff08\u30b9\u30d7\u30ea\u30f3\u30c8\u3001\u30a6\u30a7\u30a4\u30c8\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff09<\/strong><\/td><\/tr><tr><td><strong>PPARGC1A<\/strong><\/td><td><strong>\u9ad8\u6d3b\u6027<\/strong><\/td><td><strong>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5f37\u5316\u306e\u305f\u3081\u306e\u30be\u30fc\u30f32\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong><\/td><\/tr><tr><td><strong>PPARGC1A<\/strong><\/td><td><strong>\u4f4e\u6d3b\u6027<\/strong><\/td><td><strong>\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u6d3b\u7528<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>4. \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u30e1\u30ea\u30c3\u30c8<\/strong><\/h2>\n\n\n\n<p><strong>\u6700\u8fd1\u3067\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u30ad\u30c3\u30c8\u3092\u7528\u3044\u3066\u81ea\u5206\u306e\u907a\u4f1d\u7684\u50be\u5411\u3092\u77e5\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u30e1\u30ea\u30c3\u30c8\u304c\u5f97\u3089\u308c\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6700\u9069\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u65b9\u6cd5\u3092\u9078\u629e\u3067\u304d\u308b<\/strong><\/li>\n\n\n\n<li><strong>\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u52b9\u7387\u3092\u6700\u5927\u5316\u3057\u3001\u7121\u99c4\u3092\u7701\u3051\u308b<\/strong><\/li>\n\n\n\n<li><strong>\u30b1\u30ac\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3067\u304d\u308b<\/strong><\/li>\n<\/ul>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u79d1\u5b66\u7684\u306b\u52b9\u679c\u7684\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3046\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u4eca\u5f8c\u3001\u6301\u4e45\u529b\u30b9\u30dd\u30fc\u30c4\u306b\u304a\u3051\u308b\u500b\u5225\u6700\u9069\u5316\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u3055\u3089\u306b\u9032\u5316\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u6804\u990a\u6226\u7565<\/strong><\/h3>\n\n\n\n<p><strong>\u6301\u4e45\u529b\u5411\u4e0a\u306b\u306f\u3001\u9069\u5207\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3068\u4e26\u884c\u3057\u3066\u3001\u6804\u990a\u6226\u7565\u3082\u91cd\u8981\u3067\u3059\u3002\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u52b9\u7387\u3084\u7279\u5b9a\u306e\u6804\u990a\u7d20\u306e\u5fc5\u8981\u91cf\u304c\u7570\u306a\u308b\u305f\u3081\u3001\u500b\u3005\u306e\u907a\u4f1d\u7684\u7279\u6027\u306b\u5fdc\u3058\u305f\u6804\u990a\u8a08\u753b\u3092\u7acb\u3066\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u6301\u4e45\u529b\u5411\u4e0a\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) \u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h4>\n\n\n\n<p><strong>\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u52b9\u7387\u7684\u306b\u5229\u7528\u3059\u308b\u80fd\u529b\u306b\u306f\u3001PPARGC1A\u907a\u4f1d\u5b50\u3084FABP2\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PPARGC1A\u907a\u4f1d\u5b50\uff08\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u751f\u6210\u306b\u95a2\u4e0e\uff09<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u6d3b\u6027\u578b\u306e\u4eba\u306f\u8102\u80aa\u3092\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u3068\u3057\u3066\u5229\u7528\u3059\u308b\u80fd\u529b\u304c\u9ad8\u304f\u3001\u6301\u4e45\u904b\u52d5\u5411\u304d<\/strong><\/li>\n\n\n\n<li><strong>\u4f4e\u6d3b\u6027\u578b\u306e\u4eba\u306f\u70ad\u6c34\u5316\u7269\u306e\u4ee3\u8b1d\u3092\u512a\u5148\u3059\u308b\u305f\u3081\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u524d\u5f8c\u306e\u7cd6\u8cea\u6442\u53d6\u304c\u91cd\u8981<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>FABP2\u907a\u4f1d\u5b50\uff08\u8102\u80aa\u9178\u306e\u8f38\u9001\u306b\u95a2\u4e0e\uff09<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u578b\u3092\u6301\u3064\u4eba\u306f\u8102\u80aa\u306e\u6d88\u5316\u30fb\u5438\u53ce\u304c\u52b9\u7387\u7684\u3067\u306f\u306a\u3044\u305f\u3081\u3001\u70ad\u6c34\u5316\u7269\u3092\u4e2d\u5fc3\u306b\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u6442\u53d6\u3059\u308b\u65b9\u304c\u9069\u3057\u3066\u3044\u308b<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(2) \u30bf\u30f3\u30d1\u30af\u8cea\u4ee3\u8b1d\u3068\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<p><strong>\u7b4b\u6301\u4e45\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u305f\u3081\u306b\u306f\u3001\u9069\u5207\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u6442\u53d6\u3082\u91cd\u8981\u3067\u3059\u3002FTO\u907a\u4f1d\u5b50\u306f\u4f53\u8102\u80aa\u7387\u306b\u95a2\u4fc2\u3057\u3066\u304a\u308a\u3001\u9ad8\u30ea\u30b9\u30af\u578b\u3092\u6301\u3064\u4eba\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6442\u53d6\u91cf\u3092\u5897\u3084\u3059\u3053\u3068\u3067\u3001\u4f53\u8102\u80aa\u306e\u5897\u52a0\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08Sonestedt et al., 2011\uff09\u3002<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FTO\u907a\u4f1d\u5b50 \u9ad8\u30ea\u30b9\u30af\u578b\u306e\u4eba<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u30bf\u30f3\u30d1\u30af\u8cea\u98df\uff08\u4f53\u91cd1kg\u3042\u305f\u308a1.6\uff5e2.2g\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u6442\u53d6\uff09\u304c\u63a8\u5968\u3055\u308c\u308b<\/strong><\/li>\n\n\n\n<li><strong>\u4f4e\u8102\u80aa\u30fb\u9ad8\u30bf\u30f3\u30d1\u30af\u306e\u98df\u4e8b\u3092\u5fc3\u304c\u3051\u308b<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>FTO\u907a\u4f1d\u5b50 \u4f4e\u30ea\u30b9\u30af\u578b\u306e\u4eba<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u6a19\u6e96\u7684\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u6442\u53d6\uff081.2\uff5e1.6g\/kg\uff09\u3067\u5341\u5206<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(3) \u70ad\u6c34\u5316\u7269\u306e\u5229\u7528\u3068\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<p><strong>\u6301\u4e45\u529b\u30b9\u30dd\u30fc\u30c4\u3067\u306f\u70ad\u6c34\u5316\u7269\u306e\u4ee3\u8b1d\u80fd\u529b\u304c\u91cd\u8981\u306b\u306a\u308a\u307e\u3059\u304c\u3001AMY1\u907a\u4f1d\u5b50\u306e\u30b3\u30d4\u30fc\u6570\u306b\u3088\u3063\u3066\u3001\u70ad\u6c34\u5316\u7269\u306e\u6d88\u5316\u30fb\u5438\u53ce\u80fd\u529b\u304c\u7570\u306a\u308a\u307e\u3059\uff08Perry et al., 2007\uff09\u3002<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AMY1\u907a\u4f1d\u5b50\u304c\u591a\u3044\u4eba\uff08\u30b3\u30d4\u30fc\u6570\u304c\u591a\u3044\uff09<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u70ad\u6c34\u5316\u7269\u306e\u6d88\u5316\u80fd\u529b\u304c\u9ad8\u304f\u3001\u7cd6\u8cea\u3092\u52b9\u7387\u7684\u306b\u30a8\u30cd\u30eb\u30ae\u30fc\u3078\u5909\u63db\u3067\u304d\u308b<\/strong><\/li>\n\n\n\n<li><strong>\u30de\u30e9\u30bd\u30f3\u3084\u9577\u8ddd\u96e2\u8d70\u306b\u9069\u5fdc\u3057\u3084\u3059\u3044<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>AMY1\u907a\u4f1d\u5b50\u304c\u5c11\u306a\u3044\u4eba\uff08\u30b3\u30d4\u30fc\u6570\u304c\u5c11\u306a\u3044\uff09<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u7cd6\u8cea\u306e\u4ee3\u8b1d\u52b9\u7387\u304c\u4f4e\u3044\u305f\u3081\u3001\u6301\u4e45\u904b\u52d5\u6642\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044<\/strong><\/li>\n\n\n\n<li><strong>\u4f4eGI\u98df\u54c1\u3084\u8102\u8cea\u3092\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u3068\u3057\u305f\u98df\u4e8b\u6226\u7565\u3092\u63a1\u7528\u3059\u308b\u306e\u304c\u6709\u52b9<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6. \u6301\u4e45\u529b\u30b9\u30dd\u30fc\u30c4\u3068\u907a\u4f1d\u5b50\u306b\u3088\u308b\u56de\u5fa9\u529b\u306e\u9055\u3044<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"766\" src=\"\/gene\/wp-content\/uploads\/2025\/02\/31561417_m-1024x766.jpg\" alt=\"\u30de\u30e9\u30bd\u30f3\" class=\"wp-image-4337\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31561417_m-1024x766.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31561417_m-300x224.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31561417_m-768x575.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31561417_m.jpg 1176w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><strong>\u6301\u4e45\u529b\u30b9\u30dd\u30fc\u30c4\u3067\u306f\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u5f8c\u306e\u56de\u5fa9\u304c\u91cd\u8981\u306b\u306a\u308a\u307e\u3059\u3002\u56de\u5fa9\u80fd\u529b\u306b\u306fIL6\u907a\u4f1d\u5b50\u3084COL5A1\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) IL6\u907a\u4f1d\u5b50 \u2013 \u708e\u75c7\u53cd\u5fdc\u3068\u56de\u5fa9\u80fd\u529b<\/strong><\/h4>\n\n\n\n<p><strong>**IL6\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-6\uff09**\u306f\u3001\u904b\u52d5\u5f8c\u306e\u708e\u75c7\u3084\u7b4b\u640d\u50b7\u306b\u95a2\u4e0e\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3059\u3002<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IL6\u306e\u9ad8\u767a\u73fe\u578b<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u708e\u75c7\u304c\u9577\u5f15\u304d\u3084\u3059\u304f\u3001\u56de\u5fa9\u306b\u6642\u9593\u304c\u304b\u304b\u308b<\/strong><\/li>\n\n\n\n<li><strong>\u6297\u708e\u75c7\u4f5c\u7528\u306e\u3042\u308b\u98df\u54c1\uff08\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3001\u30af\u30eb\u30af\u30df\u30f3\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3068\u826f\u3044<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>IL6\u306e\u4f4e\u767a\u73fe\u578b<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u708e\u75c7\u304c\u8d77\u3053\u308a\u306b\u304f\u304f\u3001\u56de\u5fa9\u304c\u65e9\u3044<\/strong><\/li>\n\n\n\n<li><strong>\u56de\u5fa9\u6642\u9593\u3092\u77ed\u7e2e\u3057\u3001\u9ad8\u983b\u5ea6\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u53ef\u80fd<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(2) COL5A1\u907a\u4f1d\u5b50 \u2013 \u3051\u304c\u306e\u30ea\u30b9\u30af<\/strong><\/h4>\n\n\n\n<p><strong>**COL5A1\uff08\u30b3\u30e9\u30fc\u30b2\u30f3\u907a\u4f1d\u5b50\uff09**\u306f\u3001\u8171\u3084\u976d\u5e2f\u306e\u5f37\u5ea6\u306b\u95a2\u4e0e\u3057\u3001\u6301\u4e45\u7cfb\u30a2\u30b9\u30ea\u30fc\u30c8\u306e\u602a\u6211\u30ea\u30b9\u30af\u3092\u6c7a\u5b9a\u3059\u308b\u91cd\u8981\u306a\u56e0\u5b50\u3067\u3059\uff08Collins &amp; Raleigh, 2009\uff09\u3002<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u578b\u3092\u6301\u3064\u4eba<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u976d\u5e2f\u306e\u67d4\u8edf\u6027\u304c\u4f4e\u304f\u3001\u30a2\u30ad\u30ec\u30b9\u8171\u708e\u3084\u819d\u306e\u976d\u5e2f\u640d\u50b7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044<\/strong><\/li>\n\n\n\n<li><strong>\u30b9\u30c8\u30ec\u30c3\u30c1\u3084\u30d5\u30a9\u30fc\u30e0\u30ed\u30fc\u30e9\u30fc\u3092\u6d3b\u7528\u3057\u3001\u30b1\u30a2\u3092\u5fb9\u5e95\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u308b<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u6a19\u6e96\u578b\u3092\u6301\u3064\u4eba<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u976d\u5e2f\u306e\u5f37\u5ea6\u304c\u9ad8\u304f\u3001\u602a\u6211\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u3044<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7. \u907a\u4f1d\u5b50\u3068\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u5b9f\u8df5\u4f8b<\/strong><\/h3>\n\n\n\n<p><strong>\u5b9f\u969b\u306b\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u3001\u6700\u9069\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u8a2d\u8a08\u3057\u305f\u4f8b\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30b1\u30fc\u30b9\u30b9\u30bf\u30c7\u30a3 1: \u9577\u8ddd\u96e2\u30e9\u30f3\u30ca\u30fc\u306e\u4f8b<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ACTN3: XX\u578b\uff08\u6301\u4e45\u529b\u578b\uff09<\/strong><\/li>\n\n\n\n<li><strong>ACE: II\u578b\uff08\u6301\u4e45\u529b\u5411\u4e0a\uff09<\/strong><\/li>\n\n\n\n<li><strong>PPARGC1A: \u9ad8\u767a\u73fe\u578b\uff08\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u751f\u6210\u80fd\u529b\u304c\u9ad8\u3044\uff09<\/strong><\/li>\n<\/ul>\n\n\n\n<p><strong>\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u8a08\u753b\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u90315\u56de\u306e\u4f4e\u5f37\u5ea6\u6709\u9178\u7d20\u904b\u52d5\uff08LSD\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u90311\uff5e2\u56de\u306e\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong><\/li>\n\n\n\n<li><strong>\u98df\u4e8b\u306f\u4f4e\u8102\u80aa\u30fb\u9ad8\u70ad\u6c34\u5316\u7269\u4e2d\u5fc3<\/strong><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30b1\u30fc\u30b9\u30b9\u30bf\u30c7\u30a3 2: \u30c8\u30e9\u30a4\u30a2\u30b9\u30ea\u30fc\u30c8\u306e\u4f8b<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ACTN3: RX\u578b\uff08\u30d0\u30e9\u30f3\u30b9\u578b\uff09<\/strong><\/li>\n\n\n\n<li><strong>ACE: ID\u578b\uff08\u6301\u4e45\u529b\u3068\u30d1\u30ef\u30fc\u306e\u30d0\u30e9\u30f3\u30b9\uff09<\/strong><\/li>\n\n\n\n<li><strong>IL6: \u9ad8\u767a\u73fe\u578b\uff08\u708e\u75c7\u304c\u9577\u5f15\u304d\u3084\u3059\u3044\uff09<\/strong><\/li>\n<\/ul>\n\n\n\n<p><strong>\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u8a08\u753b\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u90313\u56de\u306e\u9ad8\u5f37\u5ea6\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08HIIT\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u90312\u56de\u306e\u30b9\u30d7\u30ea\u30f3\u30c8\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong><\/li>\n\n\n\n<li><strong>\u6297\u708e\u75c7\u4f5c\u7528\u306e\u3042\u308b\u98df\u54c1\uff08\u9752\u9b5a\u3001\u30bf\u30fc\u30e1\u30ea\u30c3\u30af\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6<\/strong><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8. \u307e\u3068\u3081<\/strong><\/h3>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u6301\u4e45\u529b\u5411\u4e0a\u306b\u6700\u9069\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3068\u6804\u990a\u6226\u7565\u3092\u8a2d\u8a08\u3067\u304d\u307e\u3059\u3002\u4eca\u5f8c\u3001\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u3068\u907a\u4f1d\u5b66\u304c\u3055\u3089\u306b\u767a\u5c55\u3059\u308c\u3070\u3001\u3088\u308a\u7cbe\u5bc6\u306a\u500b\u5225\u6700\u9069\u5316\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u5b9f\u73fe\u3059\u308b\u3067\u3057\u3087\u3046\u3002<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u5b9f\u8df5\u7684\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"640\" height=\"360\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/26061938_s-1.jpg\" alt=\"\u30af\u30ea\u30a2\u30ac\u30e9\u30b9DNA\u30ea\u30f3\u30b0\" class=\"wp-image-2014\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/26061938_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/26061938_s-1-300x169.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u306b\u57fa\u3065\u3044\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6cd5\u3092\u5b9f\u969b\u306b\u6d3b\u7528\u3059\u308b\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u30b9\u30c6\u30c3\u30d7\u3092\u8e0f\u3080\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u7387\u7684\u306a\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u8a2d\u8a08\u3067\u304d\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u5b9f\u65bd<\/strong><\/h4>\n\n\n\n<p><strong>\u307e\u305a\u306f\u3001\u6301\u4e45\u529b\u306b\u95a2\u308f\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50\uff08ACTN3\u3001ACE\u3001PPARGC1A\u3001IL6\u3001COL5A1\u306a\u3069\uff09\u3092\u8abf\u3079\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002\u8fd1\u5e74\u3067\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u30b5\u30fc\u30d3\u30b9\u3092\u63d0\u4f9b\u3059\u308b\u4f01\u696d\u304c\u5897\u3048\u3066\u304a\u308a\u3001\u624b\u8efd\u306b\u81ea\u5206\u306e\u907a\u4f1d\u7684\u7279\u5fb4\u3092\u77e5\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(2) \u907a\u4f1d\u5b50\u578b\u306b\u57fa\u3065\u304f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30d7\u30e9\u30f3\u306e\u8a2d\u8a08<\/strong><\/h4>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u7d50\u679c\u3092\u3082\u3068\u306b\u3001\u6700\u9069\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u65b9\u6cd5\u3092\u7d44\u307f\u5408\u308f\u305b\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001ACTN3\u304cXX\u578b\u3067ACE\u304cII\u578b\u306e\u4eba\u306f\u6301\u4e45\u529b\u5411\u4e0a\u306e\u305f\u3081\u306b\u9577\u6642\u9593\u306e\u4f4e\u5f37\u5ea6\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u512a\u5148\u3057\u3001\u9006\u306bACTN3\u304cRR\u578b\u3067ACE\u304cDD\u578b\u306e\u4eba\u306f\u9ad8\u5f37\u5ea6\u306e\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u53d6\u308a\u5165\u308c\u308b\u3068\u826f\u3044\u3067\u3057\u3087\u3046\u3002<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(3) \u6804\u990a\u6226\u7565\u306e\u6700\u9069\u5316<\/strong><\/h4>\n\n\n\n<p><strong>\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3068\u4e26\u884c\u3057\u3066\u3001\u907a\u4f1d\u7684\u7279\u5fb4\u306b\u9069\u3057\u305f\u6804\u990a\u8a08\u753b\u3092\u7acb\u3066\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002\u4f8b\u3048\u3070\u3001AMY1\u306e\u30b3\u30d4\u30fc\u6570\u304c\u5c11\u306a\u3044\u4eba\u306f\u3001\u8102\u8cea\u3092\u4e3b\u8981\u306a\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u3068\u3059\u308b\u30b1\u30c8\u30b8\u30a7\u30cb\u30c3\u30af\u30c0\u30a4\u30a8\u30c3\u30c8\u304c\u6709\u52b9\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u4e00\u65b9\u3001FABP2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u8102\u8cea\u3088\u308a\u3082\u70ad\u6c34\u5316\u7269\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u98df\u4e8b\u306e\u65b9\u304c\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u5411\u4e0a\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(4) \u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u52b9\u679c\u3092\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0<\/strong><\/h4>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6cd5\u304c\u5b9f\u969b\u306b\u52b9\u679c\u3092\u767a\u63ee\u3057\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u3001VO2max\u3084\u4e73\u9178\u95be\u5024\uff08LT\u5024\uff09\u306a\u3069\u306e\u30d5\u30a3\u30b8\u30ab\u30eb\u30c7\u30fc\u30bf\u3092\u5b9a\u671f\u7684\u306b\u6e2c\u5b9a\u3057\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u5185\u5bb9\u3092\u8abf\u6574\u3057\u307e\u3059\u3002<\/strong><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u6700\u65b0\u7814\u7a76<\/strong><\/h3>\n\n\n\n<p><strong>\u8fd1\u5e74\u3001\u907a\u4f1d\u5b50\u3068\u30b9\u30dd\u30fc\u30c4\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306b\u95a2\u3059\u308b\u7814\u7a76\u304c\u6025\u901f\u306b\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u6301\u4e45\u529b\u30b9\u30dd\u30fc\u30c4\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u306e\u89e3\u6790\u304c\u9032\u3093\u3067\u304a\u308a\u3001\u500b\u5225\u6700\u9069\u5316\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u5b9f\u7528\u5316\u306b\u5411\u3051\u305f\u53d6\u308a\u7d44\u307f\u304c\u6d3b\u767a\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) \u907a\u4f1d\u5b50\u3068\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u95a2\u4fc2<\/strong><\/h4>\n\n\n\n<p><strong>\u6301\u4e45\u7cfb\u30a2\u30b9\u30ea\u30fc\u30c8\u304c\u884c\u3046\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306f\u3001\u4f4e\u9178\u7d20\u74b0\u5883\u306b\u9069\u5fdc\u3057\u3001\u6301\u4e45\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u305f\u3081\u306e\u6709\u52b9\u306a\u624b\u6bb5\u3067\u3059\u3002\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001EPAS1\u907a\u4f1d\u5b50\u304c\u9ad8\u5730\u9069\u5fdc\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u4f4e\u9178\u7d20\u74b0\u5883\u4e0b\u3067\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u5411\u4e0a\u304c\u671f\u5f85\u3067\u304d\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08Beall et al., 2010\uff09\u3002<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>EPAS1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u578b\u3092\u6301\u3064\u4eba\uff1a\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u52b9\u679c\u304c\u5927\u304d\u304f\u3001\u9178\u7d20\u904b\u642c\u80fd\u529b\u304c\u5411\u4e0a\u3057\u3084\u3059\u3044<\/strong><\/li>\n\n\n\n<li><strong>EPAS1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u306a\u3044\u4eba\uff1a\u4f4e\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3068\u7d44\u307f\u5408\u308f\u305b\u3066\u8abf\u6574\u304c\u5fc5\u8981<\/strong><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(2) \u907a\u4f1d\u5b50\u3068\u75b2\u52b4\u8010\u6027\u306e\u95a2\u4fc2<\/strong><\/h4>\n\n\n\n<p><strong>\u6301\u4e45\u529b\u30b9\u30dd\u30fc\u30c4\u3067\u306f\u3001\u7b4b\u8089\u306e\u75b2\u52b4\u3092\u3044\u304b\u306b\u8efd\u6e1b\u3059\u308b\u304b\u304c\u91cd\u8981\u3067\u3059\u3002NRF2\u907a\u4f1d\u5b50\u306f\u3001\u6297\u9178\u5316\u4f5c\u7528\u3092\u6301\u3064\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5408\u6210\u306b\u95a2\u4e0e\u3057\u3001\u75b2\u52b4\u56de\u5fa9\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\uff08Piacentini et al., 2013\uff09\u3002<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>NRF2\u306e\u9ad8\u6d3b\u6027\u578b\uff1a\u6d3b\u6027\u9178\u7d20\u3092\u901f\u3084\u304b\u306b\u9664\u53bb\u3057\u3001\u56de\u5fa9\u304c\u65e9\u3044<\/strong><\/li>\n\n\n\n<li><strong>NRF2\u306e\u4f4e\u6d3b\u6027\u578b\uff1a\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u304f\u3001\u6297\u9178\u5316\u98df\u54c1\uff08\u30d3\u30bf\u30df\u30f3C\u3001\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306a\u3069\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u308b<\/strong><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(3) \u907a\u4f1d\u5b50\u3068\u5fc3\u7406\u7684\u8010\u4e45\u529b\u306e\u95a2\u4fc2<\/strong><\/h4>\n\n\n\n<p><strong>\u6301\u4e45\u7cfb\u30b9\u30dd\u30fc\u30c4\u3067\u306f\u3001\u30e1\u30f3\u30bf\u30eb\u306e\u5f37\u3055\u3082\u5927\u304d\u304f\u5f71\u97ff\u3057\u307e\u3059\u3002BDNF\uff08\u8133\u7531\u6765\u795e\u7d4c\u6804\u990a\u56e0\u5b50\uff09\u907a\u4f1d\u5b50\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3084\u96c6\u4e2d\u529b\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u30e1\u30f3\u30bf\u30eb\u9762\u3067\u306e\u6301\u4e45\u529b\u304c\u9ad8\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08Roth et al., 2018\uff09\u3002<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>BDNF\u306e\u9ad8\u6d3b\u6027\u578b\uff1a\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u5f37\u304f\u3001\u9577\u6642\u9593\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3067\u3082\u96c6\u4e2d\u3092\u7dad\u6301\u3057\u3084\u3059\u3044<\/strong><\/li>\n\n\n\n<li><strong>BDNF\u306e\u4f4e\u6d3b\u6027\u578b\uff1a\u30e1\u30f3\u30bf\u30eb\u9762\u3067\u306e\u30b5\u30dd\u30fc\u30c8\uff08\u7791\u60f3\u3001\u30de\u30a4\u30f3\u30c9\u30d5\u30eb\u30cd\u30b9\uff09\u304c\u52b9\u679c\u7684<\/strong><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>11. \u907a\u4f1d\u5b50\u60c5\u5831\u3068\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30b9\u30dd\u30fc\u30c4\u306e\u672a\u6765<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"574\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/31612499_m-1024x574.jpg\" alt=\"\u9678\u4e0a\uff11\" class=\"wp-image-4730\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31612499_m-1024x574.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31612499_m-300x168.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31612499_m-768x431.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31612499_m-1536x862.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31612499_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><strong>\u4eca\u5f8c\u3001\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u304c\u3055\u3089\u306b\u9032\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u6301\u4e45\u529b\u30b9\u30dd\u30fc\u30c4\u306b\u304a\u3051\u308b\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u3088\u308a\u9ad8\u5ea6\u5316\u3059\u308b\u3053\u3068\u304c\u4e88\u60f3\u3055\u308c\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) AI\u3068\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u8a2d\u8a08<\/strong><\/h4>\n\n\n\n<p><strong>\u73fe\u5728\u3001AI\u3092\u6d3b\u7528\u3057\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u958b\u767a\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002AI\u306f\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u5c65\u6b74\u3001\u98df\u4e8b\u30c7\u30fc\u30bf\u306a\u3069\u3092\u89e3\u6790\u3057\u3001\u6700\u9069\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30d7\u30e9\u30f3\u3092\u81ea\u52d5\u7684\u306b\u63d0\u6848\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(2) \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306e\u767a\u5c55<\/strong><\/h4>\n\n\n\n<p><strong>CRISPR-Cas9\u6280\u8853\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u5c06\u6765\u7684\u306b\u306f\u6301\u4e45\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u3092\u64cd\u4f5c\u3067\u304d\u308b\u53ef\u80fd\u6027\u3082\u8b70\u8ad6\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u502b\u7406\u7684\u306a\u554f\u984c\u3082\u591a\u3044\u305f\u3081\u3001\u4eca\u5f8c\u306e\u898f\u5236\u3084\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306e\u6574\u5099\u304c\u5fc5\u8981\u3067\u3059\u3002<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(3) \u907a\u4f1d\u5b50\u30c9\u30fc\u30d4\u30f3\u30b0\u306e\u554f\u984c<\/strong><\/h4>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u3092\u6539\u5909\u3057\u3066\u6301\u4e45\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u300c\u907a\u4f1d\u5b50\u30c9\u30fc\u30d4\u30f3\u30b0\u300d\u304c\u30b9\u30dd\u30fc\u30c4\u754c\u3067\u61f8\u5ff5\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e16\u754c\u30a2\u30f3\u30c1\u30fb\u30c9\u30fc\u30d4\u30f3\u30b0\u6a5f\u95a2\uff08WADA\uff09\u306f\u3001\u907a\u4f1d\u5b50\u30c9\u30fc\u30d4\u30f3\u30b0\u306e\u76e3\u8996\u3092\u5f37\u5316\u3057\u3066\u304a\u308a\u3001\u4eca\u5f8c\u306e\u30b9\u30dd\u30fc\u30c4\u502b\u7406\u306e\u89b3\u70b9\u304b\u3089\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12. \u307e\u3068\u3081<\/strong><\/h3>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u6301\u4e45\u529b\u5411\u4e0a\u306b\u6700\u9069\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3084\u6804\u990a\u6226\u7565\u3092\u8a2d\u8a08\u3067\u304d\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u4eca\u5f8c\u306e\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u3055\u3089\u306b\u7cbe\u5bc6\u306a\u500b\u5225\u6700\u9069\u5316\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u5b9f\u73fe\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/strong><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>13. \u907a\u4f1d\u5b50\u60c5\u5831\u3068\u74b0\u5883\u8981\u56e0\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h3>\n\n\n\n<p><strong>\u6301\u4e45\u529b\u306f\u907a\u4f1d\u7684\u8981\u56e0\u3060\u3051\u3067\u306a\u304f\u3001\u74b0\u5883\u8981\u56e0\u306e\u5f71\u97ff\u3082\u5927\u304d\u304f\u53d7\u3051\u307e\u3059\u3002\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u6ce8\u76ee\u3055\u308c\u308b\u4e00\u65b9\u3067\u3001\u74b0\u5883\u8981\u56e0\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u8003\u616e\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) \u907a\u4f1d\u5b50 \u00d7 \u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u74b0\u5883<\/strong><\/h4>\n\n\n\n<p><strong>\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u74b0\u5883\u306f\u3001\u907a\u4f1d\u7684\u306b\u6301\u4e45\u529b\u306b\u9069\u3057\u305f\u7279\u6027\u3092\u6301\u3064\u4eba\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u9ad8\u5730\u51fa\u8eab\u306e\u30a8\u30ea\u30fc\u30c8\u30e9\u30f3\u30ca\u30fc\u306e\u591a\u304f\u306f\u3001\u4f4e\u9178\u7d20\u74b0\u5883\u306b\u9069\u5fdc\u3059\u308b\u907a\u4f1d\u5b50\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u308c\u306b\u52a0\u3048\u3066\u5e7c\u5c11\u671f\u304b\u3089\u306e\u9ad8\u5730\u3067\u306e\u751f\u6d3b\u3084\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u7d4c\u9a13\u304c\u6301\u4e45\u529b\u5411\u4e0a\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4f8b\uff1a\u30a8\u30c1\u30aa\u30d4\u30a2\u3084\u30b1\u30cb\u30a2\u306e\u30e9\u30f3\u30ca\u30fc<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>EPAS1\u907a\u4f1d\u5b50\u304c\u9ad8\u6d3b\u6027\u306a\u500b\u4f53\u304c\u591a\u304f\u3001\u4f4e\u9178\u7d20\u74b0\u5883\u3078\u306e\u9069\u5fdc\u80fd\u529b\u304c\u9ad8\u3044<\/strong><\/li>\n\n\n\n<li><strong>\u5e7c\u5c11\u671f\u304b\u3089\u6a19\u9ad82000m\u4ee5\u4e0a\u306e\u9ad8\u5730\u3067\u751f\u6d3b\u3057\u3001\u81ea\u7136\u306b\u4f4e\u9178\u7d20\u74b0\u5883\u306b\u9069\u5fdc<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u4f8b\uff1a\u4f4e\u5730\u80b2\u3061\u306e\u30a2\u30b9\u30ea\u30fc\u30c8\u304c\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u5b9f\u65bd\u3059\u308b\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u5730\u3067\u306e\u8d64\u8840\u7403\u5897\u52a0\u304c\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u5411\u4e0a\u306b\u3064\u306a\u304c\u308b\u304c\u3001EPAS1\u306e\u6d3b\u6027\u304c\u4f4e\u3044\u4eba\u306f\u9069\u5fdc\u306b\u6642\u9593\u304c\u304b\u304b\u308b<\/strong><\/li>\n\n\n\n<li><strong>\u5f90\u3005\u306b\u9ad8\u5730\u3067\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6642\u9593\u3092\u5897\u3084\u3057\u3001\u904e\u5ea6\u306a\u75b2\u52b4\u3092\u907f\u3051\u308b\u3053\u3068\u304c\u91cd\u8981<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>\u3053\u306e\u3088\u3046\u306b\u3001\u6301\u4e45\u529b\u306b\u9069\u3057\u305f\u907a\u4f1d\u5b50\u3092\u6301\u3063\u3066\u3044\u305f\u3068\u3057\u3066\u3082\u3001\u74b0\u5883\u8981\u56e0\u304c\u9069\u5207\u3067\u306a\u3051\u308c\u3070\u6700\u5927\u9650\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u306f\u96e3\u3057\u3044\u306e\u3067\u3059\u3002<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(2) \u907a\u4f1d\u5b50 \u00d7 \u6804\u990a\u6442\u53d6<\/strong><\/h4>\n\n\n\n<p><strong>\u98df\u4e8b\u3084\u6804\u990a\u6226\u7565\u3082\u3001\u907a\u4f1d\u5b50\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3066\u6301\u4e45\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u7cd6\u8cea\u3084\u8102\u8cea\u306e\u4ee3\u8b1d\u52b9\u7387\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u3063\u3066\u3069\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u304c\u6700\u3082\u52b9\u679c\u7684\u304b\u3092\u77e5\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AMY1\u907a\u4f1d\u5b50\uff08\u70ad\u6c34\u5316\u7269\u4ee3\u8b1d\u306b\u95a2\u4e0e\uff09<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>AMY1\u30b3\u30d4\u30fc\u6570\u304c\u591a\u3044\u4eba\uff1a\u70ad\u6c34\u5316\u7269\u3092\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u3068\u3057\u3066\u52b9\u7387\u7684\u306b\u5229\u7528\u3067\u304d\u308b<\/strong><\/li>\n\n\n\n<li><strong>AMY1\u30b3\u30d4\u30fc\u6570\u304c\u5c11\u306a\u3044\u4eba\uff1a\u8840\u7cd6\u5024\u306e\u6025\u4e0a\u6607\u3092\u9632\u3050\u305f\u3081\u3001\u4f4eGI\u98df\u54c1\u3084\u8102\u8cea\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u6d3b\u7528\u3059\u308b\u65b9\u304c\u9069\u3057\u3066\u3044\u308b<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>FTO\u907a\u4f1d\u5b50\uff08\u4f53\u8102\u80aa\u3068\u98df\u6b32\u306b\u95a2\u4e0e\uff09<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u30ea\u30b9\u30af\u578b\u306e\u4eba\u306f\u3001\u9ad8\u70ad\u6c34\u5316\u7269\u98df\u3067\u306f\u8102\u80aa\u84c4\u7a4d\u304c\u9032\u307f\u3084\u3059\u3044\u305f\u3081\u3001\u4f4e\u70ad\u6c34\u5316\u7269\u30fb\u9ad8\u30bf\u30f3\u30d1\u30af\u98df\u304c\u63a8\u5968\u3055\u308c\u308b<\/strong><\/li>\n\n\n\n<li><strong>\u4f4e\u30ea\u30b9\u30af\u578b\u306e\u4eba\u306f\u3001\u6a19\u6e96\u7684\u306a\u30d0\u30e9\u30f3\u30b9\u98df\u3067\u554f\u984c\u306a\u3057<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>\u3053\u306e\u3088\u3046\u306b\u3001\u500b\u3005\u306e\u907a\u4f1d\u7684\u7279\u6027\u306b\u57fa\u3065\u3044\u3066\u6804\u990a\u8a08\u753b\u3092\u7acb\u3066\u308b\u3053\u3068\u3067\u3001\u6301\u4e45\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u52b9\u679c\u3092\u6700\u5927\u5316\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>14. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u6301\u4e45\u529b\u30b9\u30dd\u30fc\u30c4\u306e\u672a\u6765<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/24965221_s.jpg\" alt=\"\u8f1d\u304b\u3057\u3044\u672a\u6765\" class=\"wp-image-4309\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/24965221_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/24965221_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure>\n\n\n\n<p><strong>\u6301\u4e45\u529b\u30b9\u30dd\u30fc\u30c4\u306e\u5206\u91ce\u3067\u306f\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u65b0\u3057\u3044\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u767b\u5834\u3057\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) \u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30fb\u30b9\u30dd\u30fc\u30c4\u30b5\u30a4\u30a8\u30f3\u30b9\u306e\u9032\u5316<\/strong><\/h4>\n\n\n\n<p><strong>\u6700\u65b0\u306e\u7814\u7a76\u3067\u306f\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3060\u3051\u3067\u306a\u304f\u3001\u5fc3\u62cd\u5909\u52d5\uff08HRV\uff09\u3001\u8840\u6db2\u691c\u67fb\u3001\u7b4b\u8089\u9178\u7d20\u98fd\u548c\u5ea6\u306a\u3069\u306e\u751f\u7406\u5b66\u7684\u30c7\u30fc\u30bf\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u6b63\u78ba\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u8a08\u753b\u3092\u4f5c\u6210\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AI\u3092\u6d3b\u7528\u3057\u305f\u30c7\u30fc\u30bf\u5206\u6790<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u60c5\u5831 \u00d7 \u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30c7\u30fc\u30bf \u00d7 \u6804\u990a\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3057\u3001\u500b\u5225\u6700\u9069\u5316\u3055\u308c\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u81ea\u52d5\u751f\u6210<\/strong><\/li>\n\n\n\n<li><strong>\u6301\u4e45\u529b\u5411\u4e0a\u3060\u3051\u3067\u306a\u304f\u3001\u602a\u6211\u306e\u30ea\u30b9\u30af\u4f4e\u6e1b\u3084\u75b2\u52b4\u7ba1\u7406\u306b\u3082\u5fdc\u7528\u53ef\u80fd<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(2) \u907a\u4f1d\u5b50\u7de8\u96c6\u3068\u30b9\u30dd\u30fc\u30c4\u502b\u7406<\/strong><\/h4>\n\n\n\n<p><strong>\u8fd1\u5e74\u3001CRISPR-Cas9\u306a\u3069\u306e\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306e\u9032\u5316\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u30b9\u30dd\u30fc\u30c4\u80fd\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u8b70\u8ad6\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u30c9\u30fc\u30d4\u30f3\u30b0\u306e\u61f8\u5ff5<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>2021\u5e74\u306e\u6771\u4eac\u30aa\u30ea\u30f3\u30d4\u30c3\u30af\u3067\u306f\u3001WADA\uff08\u4e16\u754c\u30a2\u30f3\u30c1\u30fb\u30c9\u30fc\u30d4\u30f3\u30b0\u6a5f\u95a2\uff09\u304c\u300c\u907a\u4f1d\u5b50\u30c9\u30fc\u30d4\u30f3\u30b0\u300d\u306e\u53ef\u80fd\u6027\u3092\u76e3\u8996<\/strong><\/li>\n\n\n\n<li><strong>EPO\u907a\u4f1d\u5b50\u306e\u6539\u5909\u306b\u3088\u308b\u8d64\u8840\u7403\u5897\u52a0\u306a\u3069\u3001\u6301\u4e45\u529b\u5411\u4e0a\u3092\u76ee\u7684\u3068\u3057\u305f\u907a\u4f1d\u5b50\u64cd\u4f5c\u304c\u554f\u984c\u8996\u3055\u308c\u3066\u3044\u308b<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u7de8\u96c6\u304c\u9032\u5316\u3059\u308c\u3070\u3001\u672a\u6765\u306e\u30a2\u30b9\u30ea\u30fc\u30c8\u306f\u6301\u4e45\u529b\u3092\u9ad8\u3081\u308b\u305f\u3081\u306b\u907a\u4f1d\u5b50\u3092\u64cd\u4f5c\u3059\u308b\u6642\u4ee3\u304c\u6765\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u30b9\u30dd\u30fc\u30c4\u306e\u516c\u5e73\u6027\u3084\u502b\u7406\u306e\u554f\u984c\u3082\u3042\u308b\u305f\u3081\u3001\u4eca\u5f8c\u306e\u898f\u5236\u3084\u30eb\u30fc\u30eb\u6574\u5099\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>15. \u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u306e\u767a\u5c55\u3068\u4e00\u822c\u30a2\u30b9\u30ea\u30fc\u30c8\u3078\u306e\u5fdc\u7528<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"574\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/31612512_m-1024x574.jpg\" alt=\"\u9678\u4e0a\uff13\" class=\"wp-image-4698\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31612512_m-1024x574.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31612512_m-300x168.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31612512_m-768x431.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31612512_m-1536x862.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31612512_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><strong>\u73fe\u5728\u3001\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u306f\u30d7\u30ed\u30a2\u30b9\u30ea\u30fc\u30c8\u3060\u3051\u3067\u306a\u304f\u3001\u4e00\u822c\u306e\u30d5\u30a3\u30c3\u30c8\u30cd\u30b9\u611b\u597d\u8005\u306b\u3082\u5fdc\u7528\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) \u907a\u4f1d\u5b50\u691c\u67fb\u30ad\u30c3\u30c8\u306e\u666e\u53ca<\/strong><\/h4>\n\n\n\n<p><strong>\u8fd1\u5e74\u3001\u500b\u4eba\u5411\u3051\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u30ad\u30c3\u30c8\u304c\u5897\u3048\u3001\u624b\u8efd\u306b\u81ea\u5206\u306e\u907a\u4f1d\u7684\u7279\u6027\u3092\u77e5\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u63d0\u4f9b\u4f01\u696d\u306e\u4f8b<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>23andMe\uff08\u30a2\u30e1\u30ea\u30ab\uff09\uff1a\u30b9\u30dd\u30fc\u30c4\u80fd\u529b\u3084\u6301\u4e45\u529b\u907a\u4f1d\u5b50\u306e\u89e3\u6790<\/strong><\/li>\n\n\n\n<li><strong>DNAfit\uff08\u30a4\u30ae\u30ea\u30b9\uff09\uff1a\u500b\u5225\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff06\u6804\u990a\u30a2\u30c9\u30d0\u30a4\u30b9<\/strong><\/li>\n\n\n\n<li><strong>GeneLife\uff08\u65e5\u672c\uff09\uff1a\u65e5\u672c\u4eba\u5411\u3051\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u30b5\u30fc\u30d3\u30b9<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>\u3053\u306e\u3088\u3046\u306a\u30b5\u30fc\u30d3\u30b9\u3092\u5229\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u81ea\u5206\u306e\u907a\u4f1d\u7684\u306a\u6301\u4e45\u529b\u306e\u7279\u6027\u3092\u77e5\u308a\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3084\u98df\u4e8b\u306e\u6700\u9069\u5316\u3092\u56f3\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>16. \u3053\u308c\u304b\u3089\u306e\u6301\u4e45\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u65b9\u5411\u6027<\/strong><\/h3>\n\n\n\n<p><strong>\u4eca\u5f8c\u3001\u6301\u4e45\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306f\u3055\u3089\u306b\u79d1\u5b66\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u9032\u307f\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u300c\u7cbe\u5bc6\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u300d\u304c\u4e3b\u6d41\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AI\u3068\u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u305f\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong><\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u5b50\u89e3\u6790\u3068\u6804\u990a\u79d1\u5b66\u3092\u7d71\u5408\u3057\u305f\u30aa\u30fc\u30c0\u30fc\u30e1\u30a4\u30c9\u98df\u4e8b\u30d7\u30e9\u30f3<\/strong><\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u5b50\u6539\u5909\u3092\u9632\u3050\u305f\u3081\u306e\u30b9\u30dd\u30fc\u30c4\u502b\u7406\u3068\u30eb\u30fc\u30eb\u6574\u5099<\/strong><\/li>\n<\/ul>\n\n\n\n<p><strong>\u6301\u4e45\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u672a\u6765\u306f\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u306a\u304c\u3089\u3001\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u3044\u305f\u6700\u9069\u306a\u65b9\u6cd5\u3092\u8ffd\u6c42\u3059\u308b\u6642\u4ee3\u3078\u3068\u9032\u5316\u3057\u3066\u3044\u304f\u3067\u3057\u3087\u3046\u3002<\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>17. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u5411\u4e0a\u306e\u5b9f\u8df5\u4f8b<\/strong><\/h3>\n\n\n\n<p><strong>\u5b9f\u969b\u306b\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u3066\u6301\u4e45\u529b\u3092\u5411\u4e0a\u3055\u305b\u305f\u30a2\u30b9\u30ea\u30fc\u30c8\u306e\u4e8b\u4f8b\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>(1) \u30de\u30e9\u30bd\u30f3\u9078\u624b\u306e\u4f8b<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ACTN3: XX\u578b\uff08\u6301\u4e45\u529b\u578b\uff09<\/strong><\/li>\n\n\n\n<li><strong>ACE: II\u578b\uff08\u6301\u4e45\u529b\u5411\u4e0a\u306b\u6709\u5229\uff09<\/strong><\/li>\n\n\n\n<li><strong>PPARGC1A: \u9ad8\u767a\u73fe\u578b\uff08\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u751f\u6210\u80fd\u529b\u304c\u9ad8\u3044\uff09<\/strong><\/li>\n<\/ul>\n\n\n\n<p><strong>\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u8a08\u753b\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u90315\u56de\u306e\u4f4e\u5f37\u5ea6\u6709\u9178\u7d20\u904b\u52d5\uff08LSD\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u90311\uff5e2\u56de\u306e\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong><\/li>\n\n\n\n<li><strong>\u6804\u990a\u6226\u7565\u3068\u3057\u3066\u3001\u9ad8\u70ad\u6c34\u5316\u7269\u98df\u3068\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u306e\u6442\u53d6\u3092\u63a8\u5968<\/strong><\/li>\n<\/ul>\n\n\n\n<p><strong>\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u3082\u3068\u306b\u500b\u5225\u6700\u9069\u5316\u3057\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u52b9\u7387\u7684\u306b\u6301\u4e45\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<p><strong>\u4eca\u5f8c\u3001\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u306e\u767a\u5c55\u3068\u3068\u3082\u306b\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u6301\u4e45\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u4e00\u822c\u30a2\u30b9\u30ea\u30fc\u30c8\u306b\u3082\u5e83\u304f\u666e\u53ca\u3057\u3066\u3044\u304f\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u307e\u3068\u3081<\/strong><\/h3>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u6301\u4e45\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306f\u3001\u500b\u3005\u306e\u7279\u6027\u306b\u5fdc\u3058\u305f\u6700\u9069\u306a\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u8a2d\u8a08\u3057\u3001\u52b9\u7387\u7684\u306b\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3092\u5411\u4e0a\u3055\u305b\u308b\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u307e\u3059\u3002ACTN3\u3001ACE\u3001PPARGC1A\u306a\u3069\u306e\u907a\u4f1d\u5b50\u304c\u6301\u4e45\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u6804\u990a\u6226\u7565\u3084\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u65b9\u6cd5\u3092\u500b\u5225\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u52b9\u679c\u7684\u306a\u6301\u4e45\u529b\u5411\u4e0a\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002\u4eca\u5f8c\u3001\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u3068\u907a\u4f1d\u5b66\u306e\u9032\u5316\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u7cbe\u5bc6\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u4e00\u822c\u30a2\u30b9\u30ea\u30fc\u30c8\u306b\u3082\u5e83\u304f\u666e\u53ca\u3059\u308b\u3067\u3057\u3087\u3046\u3002<\/strong><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n<p>\u8a73\u3057\u304f\u306f <a href=\"https:\/\/www.hiro-clinic.or.jp\/gene\/clinic\/\">\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u5168\u56fd\u306e\u30af\u30ea\u30cb\u30c3\u30af\u4e00\u89a7<\/a> \u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>\u8fd1\u5e74\u3001\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u3068\u907a\u4f1d\u5b66\u306e\u878d\u5408\u304c\u9032\u307f\u3001\u500b\u3005\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u57fa\u306b\u3057\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u65b9\u6cd5\u306e\u7814\u7a76\u304c\u76db\u3093\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u6301\u4e45\u529b\u306f\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u306e\u4e21\u65b9\u306b\u3088\u3063\u3066\u6c7a\u5b9a\u3055\u308c\u307e\u3059\u304c\u3001\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u306e\u767a\u5c55\u306b\u3088\u308a\u3001\u6301\u4e45\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u7279\u5b9a 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