{"id":733,"date":"2024-12-06T03:21:23","date_gmt":"2024-12-06T03:21:23","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=733"},"modified":"2025-02-13T05:54:58","modified_gmt":"2025-02-13T05:54:58","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e6%a4%9c%e6%9f%bb%e3%81%a7%e8%a6%8b%e3%82%8b%e3%82%a2%e3%83%b3%e3%83%81%e3%82%a8%e3%82%a4%e3%82%b8%e3%83%b3%e3%82%b0%e3%81%ae%e7%a7%91%e5%ad%a6","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e6%a4%9c%e6%9f%bb%e3%81%a7%e8%a6%8b%e3%82%8b%e3%82%a2%e3%83%b3%e3%83%81%e3%82%a8%e3%82%a4%e3%82%b8%e3%83%b3%e3%82%b0%e3%81%ae%e7%a7%91%e5%ad%a6\/","title":{"rendered":"\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u898b\u308b\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u306e\u79d1\u5b66"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u8001\u5316\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u8001\u5316\u306f\u5358\u306a\u308b\u6642\u9593\u306e\u7d4c\u904e\u3067\u306f\u306a\u304f\u3001\u751f\u7269\u5b66\u7684\u306a\u30d7\u30ed\u30bb\u30b9\u306b\u3088\u3063\u3066\u9032\u884c\u3057\u307e\u3059\u3002\u305d\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u306f\u3001\u907a\u4f1d\u5b50\u306e\u5f79\u5272\u304c\u5927\u304d\u304f\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u8001\u5316\u306e\u901f\u5ea6\u3084\u5065\u5eb7\u5bff\u547d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001<strong>FOXO3\u907a\u4f1d\u5b50<\/strong>\u306f\u9577\u5bff\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306b\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u4e00\u822c\u7684\u306b\u9577\u5bff\u306e\u50be\u5411\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001<strong>SIRT1<\/strong>\u3084<strong>SIRT6<\/strong>\u3068\u3044\u3063\u305f\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u907a\u4f1d\u5b50\u306f\u3001\u7d30\u80de\u306e\u8001\u5316\u6291\u5236\u3084DNA\u4fee\u5fa9\u306b\u95a2\u4e0e\u3057\u3001\u5bff\u547d\u306e\u5ef6\u9577\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u3046\u3057\u305f\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u3092\u77e5\u308b\u3053\u3068\u3067\u3001\u500b\u3005\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u306b\u57fa\u3065\u3044\u305f\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u6226\u7565\u3092\u7acb\u3066\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3069\u306e\u3088\u3046\u306a\u5bfe\u7b56\u304c\u6709\u52b9\u304b\u3092\u79d1\u5b66\u7684\u306b\u5224\u65ad\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u306e\u53ef\u80fd\u6027<\/strong><\/h2>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u3001\u500b\u3005\u306e\u4f53\u8cea\u3084\u8001\u5316\u30ea\u30b9\u30af\u3092\u89e3\u6790\u3059\u308b\u5f37\u529b\u306a\u30c4\u30fc\u30eb\u3067\u3059\u3002\u73fe\u5728\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u907a\u4f1d\u5b50\u304c\u8001\u5316\u3084\u5065\u5eb7\u5bff\u547d\u306b\u95a2\u4fc2\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>TERT\uff08\u30c6\u30ed\u30e1\u30e9\u30fc\u30bc\u9006\u8ee2\u5199\u9175\u7d20\uff09\u907a\u4f1d\u5b50<\/strong>\uff1a\u30c6\u30ed\u30e1\u30a2\u306e\u9577\u3055\u3092\u7dad\u6301\u3057\u3001\u7d30\u80de\u306e\u5bff\u547d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3002<\/li>\n\n\n\n<li><strong>MTOR\u907a\u4f1d\u5b50<\/strong>\uff1a\u7d30\u80de\u306e\u6210\u9577\u3084\u4ee3\u8b1d\u3092\u5236\u5fa1\u3057\u3001\u8001\u5316\u306b\u95a2\u4e0e\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>APOE\u907a\u4f1d\u5b50<\/strong>\uff1a\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3001\u8133\u306e\u8001\u5316\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\uff08\u5909\u7570\uff09\u3092\u7279\u5b9a\u3057\u3001\u8001\u5316\u306e\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3067\u304d\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u306b\u57fa\u3065\u304d\u3001\u751f\u6d3b\u7fd2\u6163\u306e\u898b\u76f4\u3057\u3084\u3001\u9069\u5207\u306a\u6804\u990a\u7d20\u306e\u6442\u53d6\u306a\u3069\u3001\u500b\u5225\u306b\u6700\u9069\u306a\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u6226\u7565\u3092\u7b56\u5b9a\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/31507540_m-1024x683.jpg\" alt=\"\u30cf\u30fc\u30d6\u30c6\u30a3\u30fc\u3092\u98f2\u3080\u82e5\u3044\u5973\u6027\" class=\"wp-image-5035\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31507540_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31507540_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31507540_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31507540_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31507540_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u305d\u306e\u3082\u306e\u306f\u5909\u3048\u3089\u308c\u307e\u305b\u3093\u304c\u3001**\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\uff08\u5f8c\u6210\u907a\u4f1d\u5b66\uff09**\u306e\u7814\u7a76\u304c\u9032\u3080\u306b\u3064\u308c\u3001\u74b0\u5883\u3084\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306b\u3088\u3063\u3066\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u6574\u3067\u304d\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u4f8b\u3048\u3070\u3001\u9069\u5ea6\u306a\u904b\u52d5\u3001\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u98df\u4e8b\u3001\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u306a\u3069\u304c\u3001\u8001\u5316\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u3092\u5909\u3048\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ab\u30ed\u30ea\u30fc\u5236\u9650<\/strong>\uff1aSIRT1\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u3001\u8001\u5316\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\uff08\u8d64\u30ef\u30a4\u30f3\u7531\u6765\uff09<\/strong>\uff1a\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u5316\u3092\u4fc3\u3057\u3001\u7d30\u80de\u306e\u8001\u5316\u6291\u5236\u306b\u5bc4\u4e0e\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30e1\u30c1\u30eb\u5316\u30d1\u30bf\u30fc\u30f3\u306e\u5909\u5316<\/strong>\uff1aDNA\u30e1\u30c1\u30eb\u5316\u306e\u72b6\u614b\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u751f\u7269\u5b66\u7684\u5e74\u9f62\u3092\u63a8\u5b9a\u3057\u3001\u5065\u5eb7\u5bff\u547d\u306e\u7ba1\u7406\u306b\u6d3b\u7528\u3067\u304d\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u306e\u30b9\u30a4\u30c3\u30c1\u3092\u9069\u5207\u306b\u8abf\u6574\u3059\u308b\u3053\u3068\u3067\u3001\u52a0\u9f62\u306b\u4f34\u3046\u5909\u5316\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u6700\u65b0\u306e\u7814\u7a76\u3068\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"574\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/27552457_m-1024x574.jpg\" alt=\"\u771f\u5263\u306a\u8868\u60c5\u3092\u3057\u305f\u624b\u8853\u4e2d\u306e\u533b\u5e2b\" class=\"wp-image-3872\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/27552457_m-1024x574.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/27552457_m-300x168.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/27552457_m-768x430.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/27552457_m-1536x861.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/27552457_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u3068\u8001\u5316\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u306f\u3001\u591a\u304f\u306e\u7814\u7a76\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u4ee5\u4e0b\u306f\u3001\u4ee3\u8868\u7684\u306a\u7814\u7a76\u306e\u4e00\u90e8\u3067\u3059\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>FOXO3\u907a\u4f1d\u5b50\u3068\u9577\u5bff\u306e\u95a2\u4fc2<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7814\u7a76\u8ad6\u6587:<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3056430\/\"> &#8220;FOXO3 variants are associated with longevity in humans&#8221;<\/a><\/li>\n\n\n\n<li>\u5185\u5bb9: FOXO3\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u9577\u5bff\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>SIRT1\u3068\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u306e\u95a2\u4fc2<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7814\u7a76\u8ad6\u6587:<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3198754\/\"> &#8220;Caloric restriction and SIRT1 activation: A potential link to longevity&#8221;<\/a><\/li>\n\n\n\n<li>\u5185\u5bb9: \u30ab\u30ed\u30ea\u30fc\u5236\u9650\u304cSIRT1\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3057\u3001\u8001\u5316\u6291\u5236\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>DNA\u30e1\u30c1\u30eb\u5316\u3068\u751f\u7269\u5b66\u7684\u5e74\u9f62\u306e\u63a8\u5b9a<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7814\u7a76\u8ad6\u6587:<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4015143\/\"> &#8220;Epigenetic clock analysis of human aging&#8221;<\/a><\/li>\n\n\n\n<li>\u5185\u5bb9: DNA\u306e\u30e1\u30c1\u30eb\u5316\u30d1\u30bf\u30fc\u30f3\u3092\u5206\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u751f\u7269\u5b66\u7684\u5e74\u9f62\u3092\u8a55\u4fa1\u3067\u304d\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308b\u500b\u5225\u6700\u9069\u5316\u3055\u308c\u305f\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u6226\u7565<\/strong><\/h2>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u7d50\u679c\u3092\u57fa\u306b\u3001\u5404\u500b\u4eba\u306b\u6700\u9069\u306a\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u6226\u7565\u3092\u7acb\u3066\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002\u4f8b\u3048\u3070\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u5bfe\u7b56\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>SIRT1\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u98df\u4e8b\u3092\u6442\u308b<\/strong>\uff08\u30ca\u30c3\u30c4\u3001\u30c0\u30fc\u30af\u30c1\u30e7\u30b3\u30ec\u30fc\u30c8\u3001\u8d64\u30ef\u30a4\u30f3\u306a\u3069\uff09<\/li>\n\n\n\n<li><strong>FOXO3\u907a\u4f1d\u5b50\u3092\u6d3b\u6027\u5316\u3059\u308b\u751f\u6d3b\u7fd2\u6163<\/strong>\uff08\u9069\u5ea6\u306a\u904b\u52d5\u3001\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\uff09<\/li>\n\n\n\n<li><strong>\u30c6\u30ed\u30e1\u30a2\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u6442\u53d6<\/strong>\uff08\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3001\u30d3\u30bf\u30df\u30f3D\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u3046\u3057\u305f\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u3044\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u53d6\u308b\u3053\u3068\u3067\u3001\u8001\u5316\u306e\u901f\u5ea6\u3092\u7de9\u3084\u304b\u306b\u3057\u3001\u5065\u5eb7\u5bff\u547d\u3092\u5ef6\u3070\u3059\u3053\u3068\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"576\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/26403934_m-1024x576.jpg\" alt=\"\u907a\u4f1d\u5b50\u3000CG\" class=\"wp-image-5043\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/26403934_m-1024x576.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/26403934_m-300x169.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/26403934_m-768x432.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/26403934_m-1536x864.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/26403934_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8001\u5316\u306b\u95a2\u9023\u3059\u308b\u8981\u56e0\u306e\u4e00\u3064\u3068\u3057\u3066\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u4f4e\u4e0b\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u7d30\u80de\u5185\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u751f\u7523\u3092\u62c5\u3046\u91cd\u8981\u306a\u5c0f\u5668\u5b98\u3067\u3042\u308a\u3001\u305d\u306e\u50cd\u304d\u304c\u8870\u3048\u308b\u3068\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4e0d\u8db3\u3084\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5897\u52a0\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u3092\u6700\u9069\u5316\u3059\u308b\u3053\u3068\u304c\u3001\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5065\u5eb7\u7dad\u6301\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u907a\u4f1d\u5b50\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PGC-1\u03b1\uff08PPARGC1A\uff09<\/strong><strong><br><\/strong>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u751f\u5408\u6210\u3092\u4fc3\u9032\u3057\u3001\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u6d3b\u767a\u5316\u3055\u305b\u308b\u3002\u904b\u52d5\u306b\u3088\u3063\u3066\u3053\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>TFAM\uff08\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u8ee2\u5199\u56e0\u5b50A\uff09<\/strong><strong><br><\/strong>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u306e\u7dad\u6301\u306b\u95a2\u4e0e\u3057\u3001\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u306b\u4e0d\u53ef\u6b20\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5408\u6210\u3092\u52a9\u3051\u308b\u3002<\/li>\n\n\n\n<li><strong>NAD+\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30a2\u30c7\u30cb\u30f3\u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff09\u95a2\u9023\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u751f\u6210\u306b\u306fNAD+\u304c\u4e0d\u53ef\u6b20\u3067\u3042\u308a\u3001SIRT1\u306e\u6d3b\u6027\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3002\u52a0\u9f62\u3068\u3068\u3082\u306bNAD+\u306e\u30ec\u30d9\u30eb\u304c\u4f4e\u4e0b\u3059\u308b\u305f\u3081\u3001\u88dc\u5145\u304c\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u306b\u6709\u52b9\u3068\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001NAD+\u306e\u88dc\u5145\u306b\u3088\u308a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u304c\u5411\u4e0a\u3057\u3001\u8001\u5316\u306b\u3088\u308b\u30a8\u30cd\u30eb\u30ae\u30fc\u4e0d\u8db3\u3092\u8efd\u6e1b\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\uff08\u53c2\u8003:<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6296454\/\"> &#8220;NAD+ metabolism and its roles in cellular processes during ageing&#8221;<\/a>\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u6804\u990a\u6226\u7565<\/strong><\/h2>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u7d50\u679c\u3092\u57fa\u306b\u3001\u500b\u3005\u306e\u4f53\u8cea\u306b\u9069\u3057\u305f\u6804\u990a\u6226\u7565\u3092\u7acb\u3066\u308b\u3053\u3068\u3082\u53ef\u80fd\u3067\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u7279\u5b9a\u306e\u6804\u990a\u7d20\u3092\u88dc\u3046\u3053\u3068\u3067\u5065\u5eb7\u7dad\u6301\u304c\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u4e3b\u8981\u306a\u6804\u990a\u7d20\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3068APOE\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>APOE\u907a\u4f1d\u5b50\u306b\u306fE2\u3001E3\u3001E4\u306e3\u3064\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u304c\u3042\u308a\u3001E4\u3092\u6301\u3064\u4eba\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3068\u3055\u308c\u308b\u3002\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff08DHA\u3084EPA\uff09\u306e\u6442\u53d6\u304c\u3001APOE4\u30ad\u30e3\u30ea\u30a2\u306e\u8133\u306e\u5065\u5eb7\u7dad\u6301\u306b\u6709\u52b9\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30d3\u30bf\u30df\u30f3D\u3068VDR\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>VDR\u907a\u4f1d\u5b50\uff08\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\uff09\u306b\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u5438\u53ce\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u3042\u308b\u3002\u305d\u306e\u305f\u3081\u3001\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u65e5\u5149\u3092\u5341\u5206\u306b\u6d74\u3073\u308b\u304b\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u6d3b\u7528\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u6297\u9178\u5316\u7269\u8cea\u3068GSTP1\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>GSTP1\u907a\u4f1d\u5b50\u306f\u3001\u89e3\u6bd2\u9175\u7d20\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3S-\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u6297\u9178\u5316\u80fd\u529b\u306b\u95a2\u4e0e\u3059\u308b\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u5834\u5408\u3001\u30d3\u30bf\u30df\u30f3C\u3084\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306e\u6442\u53d6\u3092\u5897\u3084\u3059\u3053\u3068\u3067\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3078\u306e\u8010\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u7761\u7720\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u306b\u306f\u3001\u8cea\u306e\u9ad8\u3044\u7761\u7720\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u7761\u7720\u306e\u8cea\u306f\u907a\u4f1d\u5b50\u306e\u5f71\u97ff\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304a\u308a\u3001\u4ee5\u4e0b\u306e\u907a\u4f1d\u5b50\u304c\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CLOCK\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\u4f53\u5185\u6642\u8a08\u3092\u8abf\u6574\u3057\u3001\u7761\u7720\u3068\u899a\u9192\u306e\u30ea\u30ba\u30e0\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u3002\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u6982\u65e5\u30ea\u30ba\u30e0\u304c\u4e71\u308c\u3084\u3059\u304f\u306a\u308b\u3002<\/li>\n\n\n\n<li><strong>PER3\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\u7761\u7720\u6642\u9593\u306e\u9577\u3055\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3002\u77ed\u7e2e\u578b\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u77ed\u6642\u9593\u7761\u7720\u3067\u3082\u6d3b\u52d5\u3067\u304d\u308b\u50be\u5411\u304c\u3042\u308b\u304c\u3001\u9577\u671f\u7684\u306b\u306f\u5065\u5eb7\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u81ea\u8eab\u306e\u7761\u7720\u50be\u5411\u3092\u628a\u63e1\u3057\u3001\u305d\u308c\u306b\u57fa\u3065\u3044\u3066\u9069\u5207\u306a\u7761\u7720\u7fd2\u6163\u3092\u78ba\u7acb\u3059\u308b\u3053\u3068\u3067\u3001\u8001\u5316\u306e\u9032\u884c\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u5b9f\u969b\u306e\u6d3b\u7528\u4e8b\u4f8b<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"576\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/28532298_m-1024x576.jpg\" alt=\"DNA\u30a4\u30e1\u30fc\u30b8\u306e\u80cc\u666f\u7d20\u6750\" class=\"wp-image-4760\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/28532298_m-1024x576.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/28532298_m-300x169.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/28532298_m-768x432.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/28532298_m-1536x864.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/28532298_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30b1\u30fc\u30b9\u30b9\u30bf\u30c7\u30a31: \u9577\u5bff\u5bb6\u7cfb\u306e\u907a\u4f1d\u5b50\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0<\/strong><\/h3>\n\n\n\n<p>100\u6b73\u4ee5\u4e0a\u306e\u9577\u5bff\u8005\u306e\u907a\u4f1d\u5b50\u3092\u89e3\u6790\u3057\u305f\u7814\u7a76\u3067\u306f\u3001FOXO3\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u304c\u591a\u3044\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\uff08\u53c2\u8003:<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5729978\/\"> &#8220;Genetic determinants of human longevity&#8221;<\/a>\uff09\u3002\u3053\u306e\u767a\u898b\u3092\u3082\u3068\u306b\u3001\u4e00\u822c\u306e\u4eba\u3005\u304c\u81ea\u5206\u306eFOXO3\u907a\u4f1d\u5b50\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u8abf\u3079\u3001\u9069\u5207\u306a\u751f\u6d3b\u7fd2\u6163\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30b1\u30fc\u30b9\u30b9\u30bf\u30c7\u30a32: \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u7528\u3044\u305f\u500b\u5225\u5316\u30c0\u30a4\u30a8\u30c3\u30c8<\/strong><\/h3>\n\n\n\n<p>\u3042\u308b\u7814\u7a76\u3067\u306f\u3001FTO\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u304c\u80a5\u6e80\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\uff08\u53c2\u8003:<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6352182\/\"> &#8220;FTO gene and obesity: A review&#8221;<\/a>\uff09\u3002\u3053\u306e\u907a\u4f1d\u5b50\u3092\u6301\u3064\u4eba\u306f\u3001\u7279\u306b\u70ad\u6c34\u5316\u7269\u6442\u53d6\u3092\u6291\u3048\u305f\u98df\u4e8b\u304c\u52b9\u679c\u7684\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u672a\u6765\u3068\u8ab2\u984c<\/strong><\/h2>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u307e\u3059\u307e\u3059\u624b\u8efd\u306b\u306a\u308a\u3001\u500b\u4eba\u306e\u5065\u5eb7\u7ba1\u7406\u306b\u5f79\u7acb\u3064\u30c4\u30fc\u30eb\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u6d3b\u7528\u306b\u306f\u3044\u304f\u3064\u304b\u306e\u8ab2\u984c\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u3068\u502b\u7406\u306e\u554f\u984c<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u306f\u975e\u5e38\u306b\u30bb\u30f3\u30b7\u30c6\u30a3\u30d6\u306a\u500b\u4eba\u60c5\u5831\u3067\u3042\u308a\u3001\u30c7\u30fc\u30bf\u306e\u7ba1\u7406\u306b\u306f\u53b3\u683c\u306a\u30eb\u30fc\u30eb\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002\u4f01\u696d\u3084\u7814\u7a76\u6a5f\u95a2\u304c\u3069\u306e\u3088\u3046\u306b\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u6271\u3046\u304b\u306b\u3064\u3044\u3066\u306f\u3001\u900f\u660e\u6027\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u79d1\u5b66\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u84c4\u7a4d<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u3068\u8001\u5316\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u306f\u9032\u3093\u3067\u3044\u308b\u3082\u306e\u306e\u3001\u307e\u3060\u5b8c\u5168\u306b\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u73fe\u5728\u306e\u77e5\u898b\u3092\u57fa\u306b\u3057\u305f\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u6226\u7565\u304c\u3001\u5c06\u6765\u7684\u306b\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3059\u306e\u304b\u306b\u3064\u3044\u3066\u306f\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308b\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u3068\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0<\/strong><\/h2>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30b9\u306f\u8001\u5316\u3092\u52a0\u901f\u3055\u305b\u308b\u4e3b\u8981\u306a\u8981\u56e0\u306e\u4e00\u3064\u3067\u3059\u3002\u9577\u671f\u9593\u306b\u308f\u305f\u308b\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u4f53\u5185\u306e\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u3092\u5d29\u3057\u3001\u6162\u6027\u7684\u306a\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u6700\u7d42\u7684\u306b\u7d30\u80de\u306e\u8001\u5316\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u3078\u306e\u8010\u6027\u3084\u30b9\u30c8\u30ec\u30b9\u53cd\u5fdc\u306e\u5f37\u3055\u304c\u3001\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u500b\u4eba\u5dee\u304c\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30b9\u30c8\u30ec\u30b9\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>NR3C1\uff08\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u53d7\u5bb9\u4f53\uff09<\/strong><strong><br><\/strong>\u3053\u306e\u907a\u4f1d\u5b50\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308b\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306e\u50cd\u304d\u3092\u8abf\u7bc0\u3057\u307e\u3059\u3002\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u304c\u9ad8\u304f\u3001\u6162\u6027\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>COMT\uff08\u30ab\u30c6\u30b3\u30fc\u30eb-O-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff09<\/strong><strong><br><\/strong>COMT\u907a\u4f1d\u5b50\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u6642\u306b\u5206\u6ccc\u3055\u308c\u308b\u30c9\u30fc\u30d1\u30df\u30f3\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u578b\uff08Val\/Val\u578b\uff09\u306f\u3001\u30c9\u30fc\u30d1\u30df\u30f3\u306e\u5206\u89e3\u304c\u901f\u304f\u3001\u30b9\u30c8\u30ec\u30b9\u3078\u306e\u8010\u6027\u304c\u9ad8\u3044\u4e00\u65b9\u3067\u3001Met\/Met\u578b\u306f\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u4f4e\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>BDNF\uff08\u8133\u7531\u6765\u795e\u7d4c\u6804\u990a\u56e0\u5b50\uff09<\/strong><strong><br><\/strong>\u30b9\u30c8\u30ec\u30b9\u304c\u6162\u6027\u5316\u3059\u308b\u3068\u3001\u8133\u306e\u795e\u7d4c\u53ef\u5851\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u8a8d\u77e5\u6a5f\u80fd\u3084\u611f\u60c5\u306e\u5b89\u5b9a\u6027\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002BDNF\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306e\u500b\u4eba\u5dee\u3092\u628a\u63e1\u3057\u3001\u305d\u308c\u306b\u5fdc\u3058\u305f\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u6cd5\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u3001\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>NR3C1\u306e\u611f\u53d7\u6027\u304c\u9ad8\u3044\u5834\u5408<\/strong> \u2192 \u30e8\u30ac\u3084\u7791\u60f3\u3092\u7fd2\u6163\u5316\u3057\u3001\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306e\u5206\u6ccc\u3092\u6291\u3048\u308b\u3002<\/li>\n\n\n\n<li><strong>COMT\u306e\u5206\u89e3\u901f\u5ea6\u304c\u9045\u3044\u5834\u5408<\/strong> \u2192 \u6709\u9178\u7d20\u904b\u52d5\u3092\u53d6\u308a\u5165\u308c\u3001\u30c9\u30fc\u30d1\u30df\u30f3\u30ec\u30d9\u30eb\u3092\u9069\u5207\u306b\u8abf\u6574\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>BDNF\u306e\u6d3b\u6027\u304c\u4f4e\u3044\u5834\u5408<\/strong> \u2192 \u9b5a\u306e\u8102\u80aa\uff08DHA\u30fbEPA\uff09\u3092\u6442\u53d6\u3057\u3001\u8133\u306e\u5065\u5eb7\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u904b\u52d5\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u306b\u306f\u9069\u5207\u306a\u904b\u52d5\u304c\u6b20\u304b\u305b\u307e\u305b\u3093\u304c\u3001\u904b\u52d5\u306e\u52b9\u679c\u306f\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u6709\u9178\u7d20\u904b\u52d5\u304c\u52b9\u679c\u7684\u3060\u3063\u305f\u308a\u3001\u9006\u306b\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u307b\u3046\u304c\u5411\u3044\u3066\u3044\u305f\u308a\u3059\u308b\u305f\u3081\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u6700\u9069\u306a\u904b\u52d5\u30d7\u30e9\u30f3\u3092\u69cb\u7bc9\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u904b\u52d5\u80fd\u529b\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ACTN3\uff08\u03b1\u30a2\u30af\u30c1\u30cb\u30f3-3\uff09<\/strong><strong><br><\/strong>\u7b4b\u7e4a\u7dad\u306e\u7a2e\u985e\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3001\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\uff08RR\u578b\uff09\u3092\u6301\u3064\u3068\u901f\u7b4b\uff08\u77ac\u767a\u529b\u7cfb\uff09\u304c\u767a\u9054\u3057\u3084\u3059\u304f\u3001\u6301\u4e45\u529b\u3092\u5fc5\u8981\u3068\u3059\u308b\u904b\u52d5\u306b\u306f\u5411\u304b\u306a\u3044\u3002\u4e00\u65b9\u3067\u3001XX\u578b\u306e\u4eba\u306f\u9045\u7b4b\uff08\u6301\u4e45\u529b\u7cfb\uff09\u304c\u512a\u4f4d\u3067\u3001\u9577\u6642\u9593\u306e\u6709\u9178\u7d20\u904b\u52d5\u304c\u5f97\u610f\u306a\u50be\u5411\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>PPARGC1A\uff08\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u30ac\u30f3\u30de\u88dc\u52a9\u56e0\u5b501\u03b1\uff09<\/strong><strong><br><\/strong>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5897\u52a0\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3001\u6301\u4e45\u529b\u306e\u5411\u4e0a\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3002\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u9577\u6642\u9593\u306e\u904b\u52d5\u306b\u3088\u308b\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u304c\u52b9\u7387\u7684\u306b\u884c\u308f\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>IL6\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-6\uff09<\/strong><strong><br><\/strong>\u708e\u75c7\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3001\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u904b\u52d5\u5f8c\u306e\u7b4b\u8089\u306e\u56de\u5fa9\u304c\u9045\u3044\u50be\u5411\u304c\u3042\u308b\u3002\u9069\u5207\u306a\u4f11\u606f\u3092\u53d6\u308b\u3053\u3068\u3067\u3001\u30aa\u30fc\u30d0\u30fc\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u9632\u3050\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u904b\u52d5\u8a08\u753b<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ACTN3\u304cRR\u578b\u306e\u5834\u5408<\/strong> \u2192 \u77ed\u8ddd\u96e2\u8d70\u3001\u30a6\u30a7\u30a4\u30c8\u30ea\u30d5\u30c6\u30a3\u30f3\u30b0\u3001\u30b9\u30d7\u30ea\u30f3\u30c8\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u52b9\u679c\u7684\u3002<\/li>\n\n\n\n<li><strong>PPARGC1A\u304c\u9ad8\u6d3b\u6027\u306e\u5834\u5408<\/strong> \u2192 \u9577\u8ddd\u96e2\u30e9\u30f3\u30cb\u30f3\u30b0\u3001\u30b5\u30a4\u30af\u30ea\u30f3\u30b0\u3001\u767b\u5c71\u306a\u3069\u306e\u6709\u9178\u7d20\u904b\u52d5\u3092\u91cd\u8996\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>IL6\u304c\u708e\u75c7\u3092\u8d77\u3053\u3057\u3084\u3059\u3044\u5834\u5408<\/strong> \u2192 \u9069\u5207\u306a\u4f11\u606f\u3068\u6297\u708e\u75c7\u52b9\u679c\u306e\u3042\u308b\u98df\u54c1\uff08\u30bf\u30fc\u30e1\u30ea\u30c3\u30af\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff09\u3092\u6442\u53d6\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u808c\u306e\u8001\u5316<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/4494001_m-1024x683.jpg\" alt=\"\u7f8e\u5bb9\u30fb\u30b9\u30ad\u30f3\u30b1\u30a2\u30fb\u30d3\u30e5\u30fc\u30c6\u30a3\u30fc\u30fb\u6a2a\u9854\" class=\"wp-image-4675\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4494001_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4494001_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4494001_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4494001_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4494001_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u808c\u306e\u8001\u5316\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u7684\u8981\u56e0\u306e\u4e21\u65b9\u306b\u3088\u3063\u3066\u9032\u884c\u3057\u307e\u3059\u3002\u7279\u306b\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u751f\u6210\u3084\u7d2b\u5916\u7dda\u30c0\u30e1\u30fc\u30b8\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u306f\u3001\u808c\u306e\u30cf\u30ea\u3084\u30b7\u30ef\u306e\u5f62\u6210\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u808c\u306e\u8001\u5316\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>COL1A1\uff08\u30b3\u30e9\u30fc\u30b2\u30f3\u5408\u6210\u907a\u4f1d\u5b50\uff09<\/strong><strong><br><\/strong>\u3053\u306e\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u5206\u89e3\u304c\u9032\u307f\u3084\u3059\u304f\u3001\u30b7\u30ef\u304c\u3067\u304d\u3084\u3059\u3044\u3002\u30b3\u30e9\u30fc\u30b2\u30f3\u30b5\u30d7\u30ea\u3084\u30d3\u30bf\u30df\u30f3C\u306e\u6442\u53d6\u304c\u63a8\u5968\u3055\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>MMP1\uff08\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a4\u30ca\u30fc\u30bc1\uff09<\/strong><strong><br><\/strong>\u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u7d2b\u5916\u7dda\u3084\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u308b\u3002MMP1\u306e\u767a\u73fe\u304c\u9ad8\u3044\u4eba\u306f\u3001\u65e5\u713c\u3051\u6b62\u3081\u306e\u4f7f\u7528\u3092\u5fb9\u5e95\u3057\u3001\u6297\u9178\u5316\u7269\u8cea\uff08\u30a2\u30b9\u30bf\u30ad\u30b5\u30f3\u30c1\u30f3\u3084\u30d3\u30bf\u30df\u30f3E\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u306e\u304c\u52b9\u679c\u7684\u3002<\/li>\n\n\n\n<li><strong>MC1R\uff08\u30e1\u30e9\u30ce\u30b3\u30eb\u30c1\u30f31\u53d7\u5bb9\u4f53\uff09<\/strong><strong><br><\/strong>\u76ae\u819a\u306e\u8272\u7d20\u6c88\u7740\u306b\u95a2\u4e0e\u3057\u3001\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u30b7\u30df\u304c\u3067\u304d\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308b\u3002\u30d3\u30bf\u30df\u30f3C\u3084\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u3092\u542b\u3080\u30b9\u30ad\u30f3\u30b1\u30a2\u88fd\u54c1\u304c\u6709\u52b9\u3068\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u30b9\u30ad\u30f3\u30b1\u30a2\u6226\u7565<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>COL1A1\u306e\u767a\u73fe\u304c\u4f4e\u3044\u5834\u5408<\/strong> \u2192 \u30b3\u30e9\u30fc\u30b2\u30f3\u30da\u30d7\u30c1\u30c9\u3084\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u3092\u6442\u53d6\u3057\u3001\u808c\u306e\u5f3e\u529b\u3092\u7dad\u6301\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>MMP1\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u5834\u5408<\/strong> \u2192 \u65e5\u713c\u3051\u5bfe\u7b56\u3092\u5fb9\u5e95\u3057\u3001\u7d2b\u5916\u7dda\u306b\u3088\u308b\u30c0\u30e1\u30fc\u30b8\u3092\u8efd\u6e1b\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>MC1R\u304c\u6d3b\u6027\u5316\u3057\u3084\u3059\u3044\u5834\u5408<\/strong> \u2192 \u30b7\u30df\u5bfe\u7b56\u306e\u305f\u3081\u306b\u3001\u7f8e\u767d\u6210\u5206\u3092\u542b\u3080\u30b9\u30ad\u30f3\u30b1\u30a2\u3092\u53d6\u308a\u5165\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u8178\u5185\u74b0\u5883\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/22478486_m-1024x683.jpg\" alt=\"\u30d5\u30eb\u30fc\u30c4\u3001\u679c\u7269\u76db\u308a\u5408\u308f\u305b\" class=\"wp-image-4828\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/22478486_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/22478486_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/22478486_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/22478486_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/22478486_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u3092\u8003\u3048\u308b\u4e0a\u3067\u3001\u8178\u5185\u74b0\u5883\u306e\u5065\u5eb7\u306f\u7121\u8996\u3067\u304d\u307e\u305b\u3093\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u8178\u5185\u7d30\u83cc\u53e2\uff08\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\uff09\u304c\u8001\u5316\u3084\u514d\u75ab\u6a5f\u80fd\u3001\u3055\u3089\u306b\u306f\u8133\u306e\u5065\u5eb7\u306b\u307e\u3067\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u6c7a\u5b9a\u3059\u308b\u8981\u56e0\u306e\u4e00\u3064\u306b\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u8178\u5185\u74b0\u5883\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FUT2\uff08\u30d5\u30b3\u30fc\u30b9\u8ee2\u79fb\u9175\u7d202\uff09<\/strong><strong><br><\/strong>\u3053\u306e\u907a\u4f1d\u5b50\u306f\u3001\u8178\u5185\u7d30\u83cc\u306e\u5b9a\u7740\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u8178\u5185\u306e\u5584\u7389\u83cc\uff08\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\u306a\u3069\uff09\u306e\u5272\u5408\u304c\u4f4e\u304f\u306a\u308a\u3084\u3059\u304f\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u4e71\u308c\u304c\u8d77\u3053\u308a\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u4e73\u9178\u83cc\u3001\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>HLA-DQ\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\u30b0\u30eb\u30c6\u30f3\u4e0d\u8010\u6027\u3084\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u907a\u4f1d\u5b50\u3067\u3059\u3002\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u5834\u5408\u3001\u30b0\u30eb\u30c6\u30f3\u3092\u542b\u3080\u98df\u54c1\uff08\u5c0f\u9ea6\u3001\u5927\u9ea6\u3001\u30e9\u30a4\u9ea6\uff09\u3092\u6442\u53d6\u3059\u308b\u3068\u8178\u7c98\u819c\u306b\u30c0\u30e1\u30fc\u30b8\u3092\u4e0e\u3048\u3084\u3059\u304f\u306a\u308a\u3001\u8178\u5185\u74b0\u5883\u306e\u60aa\u5316\u3092\u62db\u304f\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>IL10\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-10\uff09<\/strong><strong><br><\/strong>\u708e\u75c7\u3092\u6291\u5236\u3059\u308b\u514d\u75ab\u8abf\u7bc0\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u8178\u5185\u306e\u514d\u75ab\u6a5f\u80fd\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002IL10\u306e\u767a\u73fe\u304c\u4f4e\u3044\u3068\u3001\u8178\u5185\u306e\u6162\u6027\u7684\u306a\u708e\u75c7\u304c\u8d77\u3053\u308a\u3084\u3059\u304f\u306a\u308a\u3001\u8178\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u5834\u5408\u3001\u6297\u708e\u75c7\u4f5c\u7528\u306e\u3042\u308b\u98df\u54c1\uff08\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3001\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u304c\u6709\u52b9\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u8178\u5185\u74b0\u5883\u306e\u6539\u5584<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FUT2\u306e\u5f71\u97ff\u3067\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u60aa\u3044\u5834\u5408<\/strong> \u2192 \u767a\u9175\u98df\u54c1\uff08\u30e8\u30fc\u30b0\u30eb\u30c8\u3001\u30ad\u30e0\u30c1\u3001\u7d0d\u8c46\uff09\u3084\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u98df\u7269\u7e4a\u7dad\uff09\u3092\u6442\u53d6\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>HLA-DQ\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u5834\u5408<\/strong> \u2192 \u30b0\u30eb\u30c6\u30f3\u30d5\u30ea\u30fc\u306e\u98df\u4e8b\u3092\u53d6\u308a\u5165\u308c\u3001\u8178\u306e\u8ca0\u62c5\u3092\u8efd\u6e1b\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>IL10\u306e\u767a\u73fe\u304c\u4f4e\u3044\u5834\u5408<\/strong> \u2192 \u6297\u708e\u75c7\u4f5c\u7528\u306e\u3042\u308b\u98df\u4e8b\u3092\u610f\u8b58\u3057\u3001\u8178\u5185\u306e\u708e\u75c7\u3092\u6291\u3048\u308b\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u30c7\u30c8\u30c3\u30af\u30b9\u6a5f\u80fd<\/strong><\/h2>\n\n\n\n<p>\u4f53\u5185\u306e\u8001\u5ec3\u7269\u3084\u6bd2\u7d20\u306e\u84c4\u7a4d\u306f\u3001\u8001\u5316\u3092\u52a0\u901f\u3055\u305b\u308b\u8981\u56e0\u306e\u4e00\u3064\u3067\u3059\u3002\u809d\u81d3\u306e\u89e3\u6bd2\u6a5f\u80fd\u3084\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u306e\u30c7\u30c8\u30c3\u30af\u30b9\u80fd\u529b\u306f\u3001\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u89e3\u6bd2\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>GSTP1\uff08\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3S-\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bcP1\uff09<\/strong><strong><br><\/strong>\u6d3b\u6027\u9178\u7d20\u3092\u9664\u53bb\u3059\u308b\u9175\u7d20\u306e\u4e00\u7a2e\u3067\u3001\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u89e3\u6bd2\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u53d7\u3051\u3084\u3059\u304f\u306a\u308b\u3002\u6297\u9178\u5316\u4f5c\u7528\u306e\u3042\u308b\u98df\u54c1\uff08\u30d3\u30bf\u30df\u30f3C\u3001\u7dd1\u8336\u3001\u30d6\u30ed\u30c3\u30b3\u30ea\u30fc\uff09\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u88dc\u52a9\u304c\u53ef\u80fd\u3002<\/li>\n\n\n\n<li><strong>CYP1A2\uff08\u30b7\u30c8\u30af\u30ed\u30e0P450 1A2\uff09<\/strong><strong><br><\/strong>\u30ab\u30d5\u30a7\u30a4\u30f3\u3084\u6bd2\u7d20\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3001\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u30ab\u30d5\u30a7\u30a4\u30f3\u306e\u4ee3\u8b1d\u304c\u9045\u3044\u305f\u3081\u3001\u904e\u5270\u6442\u53d6\u306b\u3088\u3063\u3066\u4e0d\u7720\u3084\u52d5\u60b8\u3092\u5f15\u304d\u8d77\u3053\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>NQO1\uff08NAD(P)H\u30ad\u30ce\u30f3\u30aa\u30ad\u30b7\u30c9\u30ec\u30c0\u30af\u30bf\u30fc\u30bc1\uff09<\/strong><strong><br><\/strong>\u6297\u9178\u5316\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3001\u6d3b\u6027\u304c\u4f4e\u3044\u3068DNA\u640d\u50b7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u30af\u30eb\u30af\u30df\u30f3\u3084\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u306e\u6442\u53d6\u304c\u63a8\u5968\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u30c7\u30c8\u30c3\u30af\u30b9\u6226\u7565<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>GSTP1\u306e\u6d3b\u6027\u304c\u4f4e\u3044\u5834\u5408<\/strong> \u2192 \u30d3\u30bf\u30df\u30f3C\u3084\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u3092\u542b\u3080\u98df\u54c1\u3092\u6442\u53d6\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>CYP1A2\u306e\u4ee3\u8b1d\u304c\u9045\u3044\u5834\u5408<\/strong> \u2192 \u30ab\u30d5\u30a7\u30a4\u30f3\u6442\u53d6\u3092\u63a7\u3048\u3081\u306b\u3057\u3001\u30c7\u30ab\u30d5\u30a7\u88fd\u54c1\u3092\u6d3b\u7528\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>NQO1\u306e\u6d3b\u6027\u304c\u4f4e\u3044\u5834\u5408<\/strong> \u2192 \u6297\u9178\u5316\u4f5c\u7528\u306e\u3042\u308b\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff08\u7dd1\u8336\u3001\u30d6\u30eb\u30fc\u30d9\u30ea\u30fc\uff09\u3092\u6442\u53d6\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/25169974_s.jpg\" alt=\"\u6df1\u547c\u5438\u3059\u308b\u5973\u6027\" class=\"wp-image-4460\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/25169974_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/25169974_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure>\n\n\n\n<p>\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306f\u8001\u5316\u3068\u5bc6\u63a5\u306b\u95a2\u4fc2\u3057\u3066\u304a\u308a\u3001\u7279\u306b\u5973\u6027\u306e\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3001\u7537\u6027\u306e\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u5206\u6ccc\u91cf\u304c\u6e1b\u5c11\u3059\u308b\u3068\u3001\u808c\u306e\u8001\u5316\u3084\u7b4b\u529b\u4f4e\u4e0b\u304c\u9032\u307f\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u30db\u30eb\u30e2\u30f3\u306e\u4ee3\u8b1d\u901f\u5ea6\u3084\u5206\u6ccc\u91cf\u304c\u7570\u306a\u308b\u305f\u3081\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u3092\u6700\u9069\u5316\u3059\u308b\u65b9\u6cd5\u3092\u898b\u3064\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30db\u30eb\u30e2\u30f3\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ESR1\uff08\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f531\uff09<\/strong><strong><br><\/strong>\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u611f\u53d7\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u9589\u7d4c\u5f8c\u306b\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3084\u76ae\u819a\u306e\u4e7e\u71e5\u304c\u8d77\u3053\u308a\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>AR\uff08\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\uff09<\/strong><strong><br><\/strong>\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u611f\u53d7\u6027\u3092\u6c7a\u5b9a\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3001\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u52a0\u9f62\u3068\u3068\u3082\u306b\u7b4b\u529b\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>SHBG\uff08\u6027\u30db\u30eb\u30e2\u30f3\u7d50\u5408\u30b0\u30ed\u30d6\u30ea\u30f3\uff09<\/strong><strong><br><\/strong>\u6027\u30db\u30eb\u30e2\u30f3\u306e\u8840\u4e2d\u6fc3\u5ea6\u3092\u8abf\u7bc0\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3001\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3084\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306e\u7ba1\u7406<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ESR1\u306e\u5f71\u97ff\u3067\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u611f\u53d7\u6027\u304c\u4f4e\u3044\u5834\u5408<\/strong> \u2192 \u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u3084\u30d7\u30e9\u30bb\u30f3\u30bf\u3092\u6442\u53d6\u3057\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u4f5c\u7528\u3092\u88dc\u52a9\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>AR\u306e\u5f71\u97ff\u3067\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u611f\u53d7\u6027\u304c\u4f4e\u3044\u5834\u5408<\/strong> \u2192 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class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u672a\u6765\u3068\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u533b\u7642<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/2831982_s-1.jpg\" alt=\"\u907a\u4f1d\u5b50\u3001\u79d1\u5b66\u3001DNA\u30a4\u30e1\u30fc\u30b8\" class=\"wp-image-2702\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2831982_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2831982_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" 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\u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u3068AI\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u7cbe\u5bc6\u306a\u5065\u5eb7\u4e88\u6e2c\u304c\u53ef\u80fd\u306b\u306a\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306e\u5fdc\u7528<\/strong> \u2192 \u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u6280\u8853\u304c\u767a\u5c55\u3057\u3001\u8001\u5316\u4e88\u9632\u3084\u75be\u60a3\u30ea\u30b9\u30af\u306e\u8efd\u6e1b\u306b\u8ca2\u732e\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u65b0\u305f\u306a\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u958b\u767a<\/strong> \u2192 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