{"id":8646,"date":"2025-03-07T02:52:05","date_gmt":"2025-03-07T02:52:05","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=8646"},"modified":"2025-04-10T03:49:48","modified_gmt":"2025-04-10T03:49:48","slug":"column-bone-density-genetics","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/column-bone-density-genetics\/","title":{"rendered":"\u907a\u4f1d\u5b50\u60c5\u5831\u3067\u898b\u308b\u9aa8\u5bc6\u5ea6\u3068\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u30ea\u30b9\u30af"},"content":{"rendered":"\n<p>\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3084\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u767a\u75c7\u306b\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u591a\u578b\u304c\u9aa8\u5bc6\u5ea6\u3084\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u9aa8\u5bc6\u5ea6\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2\u3001\u4e3b\u8981\u306a\u95a2\u9023\u907a\u4f1d\u5b50\u3001\u305d\u3057\u3066\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u4e88\u9632\u30fb\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u9aa8\u5bc6\u5ea6\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u9aa8\u5bc6\u5ea6\uff08Bone Mineral Density: BMD\uff09\u306f\u3001\u9aa8\u306e\u5f37\u5ea6\u3092\u793a\u3059\u6307\u6a19\u3067\u3042\u308a\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u3084\u9aa8\u6298\u306e\u30ea\u30b9\u30af\u8a55\u4fa1\u306b\u7528\u3044\u3089\u308c\u307e\u3059\u3002BMD\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u7684\u8981\u56e0\u306e\u53cc\u65b9\u304b\u3089\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u304c\u3001\u53cc\u5b50\u3084\u5bb6\u65cf\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u3067\u306f\u3001BMD\u306e\u907a\u4f1d\u7387\u304c\u9ad8\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u8e35\u9aa8\u306eBMD\u306b\u95a2\u3059\u308b\u7814\u7a76\u3067\u306f\u3001\u907a\u4f1d\u7387\u304c82\uff05\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001\u907a\u4f1d\u5b50\u304c\u9aa8\u5bc6\u5ea6\u306e\u500b\u4eba\u5dee\u306b\u5927\u304d\u304f\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08GWAS\uff09\u306b\u3088\u308a\u3001\u9aa8\u5bc6\u5ea6\u3084\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306b\u95a2\u9023\u3059\u308b\u8907\u6570\u306e\u907a\u4f1d\u5b50\u5ea7\u4f4d\u304c\u540c\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c2acf990-7fff-deec-cfb7-7ffabb6e325e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u9aa8\u5bc6\u5ea6\u304a\u3088\u3073\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306b\u95a2\u9023\u3059\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50<\/strong><\/h2>\n\n\n\n<p>\u9aa8\u5bc6\u5ea6\u3084\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u30ea\u30b9\u30af\u306b\u95a2\u9023\u3059\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50\u3068\u3057\u3066\u3001\u4ee5\u4e0b\u306e\u3082\u306e\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\uff08VDR\uff09\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\uff08VDR\uff09\u907a\u4f1d\u5b50\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u4f5c\u7528\u3092\u5a92\u4ecb\u3059\u308b\u53d7\u5bb9\u4f53\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002VDR\u907a\u4f1d\u5b50\u306e\u591a\u578b\u306f\u3001\u9aa8\u5bc6\u5ea6\u3084\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001VDR\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u591a\u578b\u304c\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\uff08ER\uff09\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\uff08ER\uff09\u907a\u4f1d\u5b50\u306f\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u4f5c\u7528\u3092\u5a92\u4ecb\u3059\u308b\u53d7\u5bb9\u4f53\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002ER\u907a\u4f1d\u5b50\u306e\u591a\u578b\u3082\u3001\u9aa8\u5bc6\u5ea6\u3084\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001ER\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u591a\u578b\u304c\u8170\u690e\u9aa8\u5bc6\u5ea6\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c2acf990-7fff-deec-cfb7-7ffabb6e325e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \u30b3\u30e9\u30fc\u30b2\u30f3\u30bf\u30a4\u30d7I\u03b11\uff08COL1A1\uff09\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>COL1A1\u907a\u4f1d\u5b50\u306f\u3001\u9aa8\u306e\u4e3b\u8981\u306a\u69cb\u6210\u6210\u5206\u3067\u3042\u308bI\u578b\u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u591a\u578b\u306f\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3084\u9aa8\u6298\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001COL1A1\u907a\u4f1d\u5b50\u306eSp1\u591a\u578b\u304c\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u60a3\u8005\u306b\u304a\u3044\u3066\u9ad8\u983b\u5ea6\u3067\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4. \u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\uff08MMP\uff09\u907a\u4f1d\u5b50\u7fa4<\/strong><\/h3>\n\n\n\n<p>MMP\u907a\u4f1d\u5b50\u7fa4\u306f\u3001\u9aa8\u57fa\u8cea\u306e\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u306b\u95a2\u4e0e\u3059\u308b\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u904e\u5270\u306a\u6d3b\u6027\u5316\u306f\u3001\u9aa8\u5438\u53ce\u306e\u5897\u52a0\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3084\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u9032\u884c\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5. \u30b5\u30fc\u30c1\u30e5\u30a4\u30f37\uff08SIRT7\uff09\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>SIRT7\u907a\u4f1d\u5b50\u306f\u3001\u9aa8\u5f62\u6210\u306b\u5fc5\u9808\u306e\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u3092\u6d3b\u6027\u5316\u3059\u308b\u65b0\u3057\u3044\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002SIRT7\u907a\u4f1d\u5b50\u6b20\u640d\u30de\u30a6\u30b9\u3067\u306f\u3001\u9aa8\u91cf\u304c\u6e1b\u5c11\u3057\u3001\u9aa8\u5f62\u6210\u304a\u3088\u3073\u9aa8\u82bd\u7d30\u80de\u6570\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u4e88\u9632\u30fb\u6cbb\u7642\u306e\u53ef\u80fd\u6027<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/29204025_m-1024x683.jpg\" alt=\"\u7b11\u9854\u3067\u8a71\u3059\u5973\u6027\u60a3\u8005\u3068\u533b\u8005\u306e\u6a2a\u9854\" class=\"wp-image-8009\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/29204025_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/29204025_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/29204025_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/29204025_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/29204025_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u3005\u306e\u9aa8\u5bc6\u5ea6\u3084\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3057\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u4e88\u9632\u30fb\u6cbb\u7642\u6cd5\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002\u4ee5\u4e0b\u306b\u5177\u4f53\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308b\u30ea\u30b9\u30af\u8a55\u4fa1<\/strong><\/h3>\n\n\n\n<p>\u500b\u4eba\u306e\u907a\u4f1d\u5b50\u591a\u578b\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3084\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3067\u304d\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001VDR\u907a\u4f1d\u5b50\u3084ER\u907a\u4f1d\u5b50\u306e\u591a\u578b\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3057\u3001\u65e9\u671f\u306e\u4ecb\u5165\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u533b\u7642\u306e\u5b9f\u73fe<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u304d\u3001\u500b\u3005\u306e\u60a3\u8005\u306b\u6700\u9069\u306a\u6cbb\u7642\u6cd5\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u591a\u578b\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u3084\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u88dc\u5145\u7642\u6cd5\u304c\u52b9\u679c\u7684\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" style=\"font-size:19px\"><strong>3. \u65b0\u898f\u6cbb\u7642\u6a19\u7684\u306e\u767a\u898b<\/strong><\/h2>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7814\u7a76\u306b\u3088\u308a\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3092\u5f15\u304d\u8d77\u3053\u3059\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u89e3\u660e\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u5f93\u6765\u306e\u6cbb\u7642\u6cd5\u3067\u306f\u5bfe\u51e6\u3057\u304d\u308c\u306a\u304b\u3063\u305f\u65b0\u305f\u306a\u6a19\u7684\u304c\u898b\u3064\u304b\u308a\u3001\u9769\u65b0\u7684\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c2acf990-7fff-deec-cfb7-7ffabb6e325e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>A. Wnt\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u30bf\u30fc\u30b2\u30c6\u30a3\u30f3\u30b0<\/strong><\/h3>\n\n\n\n<p>Wnt\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306f\u3001\u9aa8\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\u91cd\u8981\u306a\u7d4c\u8def\u3067\u3059\u3002\u7279\u306b\u3001<strong>LRP5\u907a\u4f1d\u5b50<\/strong>\uff08\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u53d7\u5bb9\u4f53\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea5\uff09\u306f\u3001Wnt\u30b7\u30b0\u30ca\u30eb\u306e\u6d3b\u6027\u5316\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u9aa8\u5bc6\u5ea6\u3092\u6c7a\u5b9a\u3059\u308b\u91cd\u8981\u306a\u56e0\u5b50\u306e\u4e00\u3064\u3067\u3059\u3002<br>\u907a\u4f1d\u5b50\u5909\u7570\u306b\u3088\u3063\u3066LRP5\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u9aa8\u5f62\u6210\u304c\u6291\u5236\u3055\u308c\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002\u3053\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u5fdc\u7528\u3057\u3001LRP5\u3092\u6d3b\u6027\u5316\u3059\u308b\u85ac\u5264\u306e\u958b\u767a\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5b9f\u969b\u306b\u3001\u6297\u30b9\u30af\u30ec\u30ed\u30b9\u30c1\u30f3\u6297\u4f53\uff08<strong>\u30ed\u30e2\u30bd\u30ba\u30de\u30d6<\/strong>\uff09\u306f\u3001\u3053\u306eWnt\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u3057\u3044\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u6cbb\u7642\u85ac\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30b9\u30af\u30ec\u30ed\u30b9\u30c1\u30f3\u306f\u9aa8\u5f62\u6210\u3092\u6291\u5236\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u3053\u308c\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067Wnt\u30b7\u30b0\u30ca\u30eb\u304c\u6d3b\u6027\u5316\u3055\u308c\u3001\u9aa8\u5bc6\u5ea6\u306e\u5897\u52a0\u304c\u4fc3\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>B. RANK\/RANKL\/OPG\u30b7\u30b0\u30ca\u30eb\u306e\u8abf\u7bc0<\/strong><\/h3>\n\n\n\n<p>\u7834\u9aa8\u7d30\u80de\u306e\u6d3b\u6027\u5316\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059**RANK\uff08\u53d7\u5bb9\u4f53\u6d3b\u6027\u5316NF-\u03baB\u56e0\u5b50\uff09<strong>\u3068\u305d\u306e\u30ea\u30ac\u30f3\u30c9\u3067\u3042\u308b<\/strong>RANKL\uff08RANK\u30ea\u30ac\u30f3\u30c9\uff09**\u306f\u3001\u9aa8\u5438\u53ce\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3059\u308b\u91cd\u8981\u306a\u56e0\u5b50\u3067\u3059\u3002\u307e\u305f\u3001**\u30aa\u30b9\u30c6\u30aa\u30d7\u30ed\u30c6\u30b2\u30ea\u30f3\uff08OPG\uff09**\u306fRANKL\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u7834\u9aa8\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u6291\u5236\u3057\u3001\u9aa8\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u50cd\u304d\u3092\u6301\u3061\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001<strong>RANKL\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u9ad8\u3044\u4eba\u307b\u3069\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b<\/strong>\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u77e5\u898b\u3092\u6d3b\u304b\u3057\u3001RANKL\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u3066\u304a\u308a\u3001\u4ee3\u8868\u7684\u306a\u85ac\u5264\u304c<strong>\u30c7\u30ce\u30b9\u30de\u30d6<\/strong>\uff08\u6297RANKL\u6297\u4f53\uff09\u3067\u3059\u3002\u30c7\u30ce\u30b9\u30de\u30d6\u306f\u3001RANKL\u306e\u50cd\u304d\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u7834\u9aa8\u7d30\u80de\u306e\u6d3b\u6027\u3092\u6291\u3048\u3001\u9aa8\u5bc6\u5ea6\u3092\u7dad\u6301\u3059\u308b\u52b9\u679c\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c2acf990-7fff-deec-cfb7-7ffabb6e325e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>C. \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u306e\u6700\u9069\u5316<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"766\" src=\"\/gene\/wp-content\/uploads\/2025\/02\/31783250_m-1024x766.jpg\" alt=\"\" class=\"wp-image-8214\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31783250_m-1024x766.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31783250_m-300x224.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31783250_m-768x575.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/31783250_m.jpg 1176w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8fd1\u5e74\u3001<strong>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5065\u5eb7\u304c\u9aa8\u4ee3\u8b1d\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059<\/strong>\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u7279\u306b\u3001\u9aa8\u82bd\u7d30\u80de\u3084\u7834\u9aa8\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u306b\u5927\u304d\u304f\u4f9d\u5b58\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001<strong>PGC-1\u03b1\u907a\u4f1d\u5b50<\/strong>\uff08PPARGC1A\uff09\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u751f\u5408\u6210\u3092\u8abf\u7bc0\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u306e\u4e00\u3064\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u9aa8\u5f62\u6210\u304c\u4f4e\u4e0b\u3057\u3001\u9aa8\u5bc6\u5ea6\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u3067\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3092\u9632\u3050\u65b0\u3057\u3044\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u6a21\u7d22\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001NAD\u207a\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30a2\u30c7\u30cb\u30f3\u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff09\u3092\u5897\u52a0\u3055\u305b\u308b**\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\uff08SIRT1\uff09**\u306e\u6d3b\u6027\u5316\u3082\u3001\u9aa8\u306e\u5065\u5eb7\u306b\u30d7\u30e9\u30b9\u306e\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002SIRT1\u3092\u6d3b\u6027\u5316\u3059\u308b\u7269\u8cea\u3068\u3057\u3066\u3001\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u3084\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30e2\u30ce\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff08NMN\uff09\u304c\u7814\u7a76\u3055\u308c\u3066\u304a\u308a\u3001\u4eca\u5f8c\u306e\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u6cbb\u7642\u306b\u5fdc\u7528\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u6700\u9069\u5316<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u500b\u4eba\u306e\u9aa8\u5bc6\u5ea6\u30ea\u30b9\u30af\u306b\u5fdc\u3058\u305f\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u6539\u5584\u7b56\u3092\u7acb\u6848\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u7279\u306b\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u5bfe\u7b56\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u6804\u990a\u6226\u7565\u306e\u6700\u9069\u5316<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u591a\u578b\u306b\u3088\u3063\u3066\u3001<strong>\u30ab\u30eb\u30b7\u30a6\u30e0\u3084\u30d3\u30bf\u30df\u30f3D\u306e\u4ee3\u8b1d\u52b9\u7387\u306b\u500b\u4eba\u5dee<\/strong>\u304c\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001VDR\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u901a\u5e38\u3088\u308a\u3082\u591a\u304f\u306e\u30d3\u30bf\u30df\u30f3D\u3092\u5fc5\u8981\u3068\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u5834\u5408\u3001\u9069\u5207\u306a\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6442\u53d6\u304c\u9aa8\u5bc6\u5ea6\u306e\u7dad\u6301\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001COL1A1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba\u306f\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u751f\u6210\u80fd\u529b\u304c\u4f4e\u4e0b\u3059\u308b\u305f\u3081\u3001\u30bc\u30e9\u30c1\u30f3\u3084\u30b3\u30e9\u30fc\u30b2\u30f3\u30da\u30d7\u30c1\u30c9\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u9aa8\u306e\u5065\u5eb7\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u904b\u52d5\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u30ab\u30b9\u30bf\u30de\u30a4\u30ba<\/strong><\/h4>\n\n\n\n<p>\u9aa8\u5bc6\u5ea6\u3092\u9ad8\u3081\u308b\u305f\u3081\u306b\u306f\u3001\u9069\u5207\u306a\u904b\u52d5\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u304c\u3001<strong>\u907a\u4f1d\u7684\u306b\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u304f\u306a\u308a\u3084\u3059\u3044\u4eba\u306f\u3001\u7279\u5b9a\u306e\u904b\u52d5\u304c\u52b9\u679c\u7684<\/strong>\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u3063\u3066<strong>ACTN3\u907a\u4f1d\u5b50\u306e\u591a\u578b<\/strong>\u304c\u5206\u304b\u308c\u3070\u3001\u305d\u306e\u4eba\u306e\u7b4b\u8089\u306e\u30bf\u30a4\u30d7\u306b\u5fdc\u3058\u305f\u6700\u9069\u306a\u904b\u52d5\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u8a2d\u8a08\u3067\u304d\u307e\u3059\u3002ACTN3\u306e\u300cRR\u578b\u300d\u3092\u6301\u3064\u4eba\u306f\u3001\u9ad8\u5f37\u5ea6\u306e\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08\u30a6\u30a7\u30a4\u30c8\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff09\u304c\u52b9\u679c\u7684\u3067\u3059\u304c\u3001\u300cXX\u578b\u300d\u306e\u4eba\u306f\u6301\u4e45\u7cfb\u306e\u904b\u52d5\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u9aa8\u5bc6\u5ea6\u3092\u3088\u308a\u52b9\u679c\u7684\u306b\u7dad\u6301\u3067\u304d\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3. \u7761\u7720\u3068\u9aa8\u306e\u5065\u5eb7<\/strong><\/h4>\n\n\n\n<p>\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001<strong>\u7761\u7720\u3068\u9aa8\u5bc6\u5ea6\u306e\u9593\u306b\u5f37\u3044\u95a2\u9023\u304c\u3042\u308b<\/strong>\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001<strong>CLOCK\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong>\u304c\u3042\u308b\u3068\u3001\u6982\u65e5\u30ea\u30ba\u30e0\u306e\u4e71\u308c\u304c\u751f\u3058\u3084\u3059\u304f\u306a\u308a\u3001\u9aa8\u5f62\u6210\u306b\u3082\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u306e\u305f\u3081\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3092\u4e88\u9632\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u5341\u5206\u306a\u7761\u7720\u6642\u9593\u3092\u78ba\u4fdd\u3057\u3001\u7761\u7720\u306e\u8cea\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002\u907a\u4f1d\u7684\u306b\u6982\u65e5\u30ea\u30ba\u30e0\u304c\u4e71\u308c\u3084\u3059\u3044\u4eba\u306f\u3001\u7279\u306b**\u30e1\u30e9\u30c8\u30cb\u30f3\u5206\u6ccc\u3092\u4fc3\u9032\u3059\u308b\u5bfe\u7b56\uff08\u4f8b\uff1a\u5c31\u5bdd\u524d\u306e\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\u30ab\u30c3\u30c8\u3001\u30e1\u30e9\u30c8\u30cb\u30f3\u30b5\u30d7\u30ea\u306e\u6d3b\u7528\uff09**\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u9aa8\u306e\u5065\u5eb7\u3092\u5b88\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u672a\u6765\u306e\u5c55\u671b<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/02\/30465638_m-1024x683.jpg\" alt=\"\u7d0d\u8c46\u3092\u304b\u304d\u6df7\u305c\u308b\u4eba\u306e\u624b\u5143\" class=\"wp-image-5910\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/30465638_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/30465638_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/30465638_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/30465638_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/30465638_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u4eca\u5f8c\u3001\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u3088\u308a\u6b63\u78ba\u306a\u9aa8\u5bc6\u5ea6\u30ea\u30b9\u30af\u306e\u8a55\u4fa1\u304c\u53ef\u80fd\u306b\u306a\u308a\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u767a\u5c55\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u3044\u305f\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30fb\u30d8\u30eb\u30b9\u30b1\u30a2\u304c\u666e\u53ca\u3059\u308c\u3070\u3001<strong>\u65e9\u671f\u306e\u30ea\u30b9\u30af\u8a55\u4fa1\u3001\u4e88\u9632\u7b56\u306e\u5f37\u5316\u3001\u52b9\u679c\u7684\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a<\/strong>\u304c\u53ef\u80fd\u3068\u306a\u308a\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u767a\u75c7\u3092\u5927\u5e45\u306b\u6291\u5236\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001AI\u3068\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u4e00\u4eba\u3072\u3068\u308a\u306b\u6700\u9069\u306a\u6804\u990a\u30fb\u904b\u52d5\u30fb\u6cbb\u7642\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u63d0\u6848\u3059\u308b\u30b7\u30b9\u30c6\u30e0\u306e\u958b\u767a<\/strong>\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u9aa8\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306e\u6226\u7565\u304c\u3001\u3088\u308a\u7cbe\u5bc6\u3067\u79d1\u5b66\u7684\u306a\u3082\u306e\u306b\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-0a99ff83-7fff-914c-7a6c-ee00615fbb98\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u9aa8\u5bc6\u5ea6\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u8fd1\u5e74\u3001**\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\uff08\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u5f8c\u5929\u7684\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\uff09**\u304c\u9aa8\u5bc6\u5ea6\u3084\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306e\u7814\u7a76\u306f\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3092\u4e88\u9632\u3057\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u767a\u75c7\u3092\u9045\u3089\u305b\u308b\u65b0\u3057\u3044\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>A. DNA\u30e1\u30c1\u30eb\u5316\u3068\u9aa8\u5bc6\u5ea6<\/strong><\/h3>\n\n\n\n<p>DNA\u30e1\u30c1\u30eb\u5316\u306f\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u4ee3\u8868\u7684\u306a\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u3064\u3067\u3059\u3002\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u60a3\u8005\u306e\u9aa8\u7d30\u80de\u3092\u5206\u6790\u3057\u305f\u7814\u7a76\u3067\u306f\u3001\u9aa8\u5f62\u6210\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\uff08<strong>RUNX2, OPG, SOST<\/strong> \u306a\u3069\uff09\u306eDNA\u30e1\u30c1\u30eb\u5316\u30d1\u30bf\u30fc\u30f3\u304c\u5909\u5316\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001<strong>SOST\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u9aa8\u5f62\u6210\u3092\u6291\u5236\u3059\u308b\u30b9\u30af\u30ec\u30ed\u30b9\u30c1\u30f3\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306eDNA\u30e1\u30c1\u30eb\u5316\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001SOST\u306e\u767a\u73fe\u304c\u5897\u52a0\u3057\u3001\u9aa8\u5f62\u6210\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u305f\u3081\u3001SOST\u306e\u30e1\u30c1\u30eb\u5316\u30ec\u30d9\u30eb\u3092\u8abf\u6574\u3059\u308b\u3053\u3068\u3067\u3001\u9aa8\u5bc6\u5ea6\u306e\u7dad\u6301\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>B. \u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u3068\u9aa8\u4ee3\u8b1d<\/strong><\/h3>\n\n\n\n<p>\u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u3082\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u91cd\u8981\u306a\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u3059\u3002\u30d2\u30b9\u30c8\u30f3\u30a2\u30bb\u30c1\u30eb\u5316\u3084\u30e1\u30c1\u30eb\u5316\u306e\u5909\u5316\u304c\u3001\u9aa8\u5f62\u6210\u3084\u9aa8\u5438\u53ce\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001**\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\uff08HDAC\uff09**\u306e\u6d3b\u6027\u304c\u9ad8\u307e\u308b\u3068\u3001\u9aa8\u5f62\u6210\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u6291\u5236\u3055\u308c\u3001\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u305f\u3081\u3001HDAC\u963b\u5bb3\u5264\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u9aa8\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>EZH2\u907a\u4f1d\u5b50<\/strong>\uff08\u30d2\u30b9\u30c8\u30f3\u30e1\u30c1\u30eb\u5316\u9175\u7d20\uff09\u306f\u3001\u9aa8\u82bd\u7d30\u80de\u306e\u5206\u5316\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002EZH2\u306e\u6d3b\u6027\u3092\u8abf\u6574\u3059\u308b\u3053\u3068\u3067\u3001\u9aa8\u5bc6\u5ea6\u3092\u7dad\u6301\u3059\u308b\u65b0\u3057\u3044\u6226\u7565\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>C. \u30de\u30a4\u30af\u30edRNA\u3068\u9aa8\u5bc6\u5ea6\u306e\u8abf\u7bc0<\/strong><\/h3>\n\n\n\n<p>\u30de\u30a4\u30af\u30edRNA\uff08miRNA\uff09\u306f\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u77ed\u3044RNA\u5206\u5b50\u3067\u3042\u308a\u3001\u9aa8\u5f62\u6210\u3084\u9aa8\u5438\u53ce\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u5b9a\u306emiRNA\u304c\u9aa8\u82bd\u7d30\u80de\u3084\u7834\u9aa8\u7d30\u80de\u306e\u5206\u5316\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001<strong>miR-21<\/strong>\u306f\u3001\u9aa8\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308bTGF-\u03b2\u30b7\u30b0\u30ca\u30eb\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u9aa8\u5bc6\u5ea6\u3092\u9ad8\u3081\u308b\u4f5c\u7528\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001<strong>miR-133a<\/strong>\u306f\u3001RUNX2\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u6291\u5236\u3057\u3001\u9aa8\u82bd\u7d30\u80de\u306e\u5206\u5316\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-0a99ff83-7fff-914c-7a6c-ee00615fbb98\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u6804\u990a\u3068\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/31179151_m-1-1024x683.jpg\" alt=\"\u3044\u308d\u3093\u306a\u8272\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\" class=\"wp-image-4707\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31179151_m-1-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31179151_m-1-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31179151_m-1-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31179151_m-1-1536x1025.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31179151_m-1.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u9aa8\u5bc6\u5ea6\u306e\u7dad\u6301\u306b\u306f\u3001\u98df\u4e8b\u3084\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u901a\u3058\u305f\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u8abf\u7bc0\u304c\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>A. \u30d3\u30bf\u30df\u30f3D\u3068\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9<\/strong><\/h3>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u306f\u3001VDR\u907a\u4f1d\u5b50\u3092\u4ecb\u3057\u3066\u9aa8\u4ee3\u8b1d\u3092\u8abf\u7bc0\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u4f5c\u7528\u3092\u6301\u3064\u3053\u3068\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u30d3\u30bf\u30df\u30f3D\u306f<strong>DNA\u30e1\u30c1\u30eb\u5316\u3084\u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u3092\u8abf\u6574<\/strong>\u3059\u308b\u3053\u3068\u3067\u3001\u9aa8\u5f62\u6210\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5897\u52a0\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001\u30d3\u30bf\u30df\u30f3D\u304c\u4e0d\u8db3\u3059\u308b\u3068\u3001<strong>RUNX2\u3084COL1A1\u907a\u4f1d\u5b50\u306eDNA\u30e1\u30c1\u30eb\u5316\u304c\u5897\u52a0<\/strong>\u3057\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u305f\u3081\u3001\u30d3\u30bf\u30df\u30f3D\u3092\u9069\u5207\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u8abf\u7bc0\u3092\u901a\u3058\u3066\u9aa8\u5bc6\u5ea6\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>B. \u30e1\u30c1\u30eb\u57fa\u4f9b\u4e0e\u4f53\uff08\u8449\u9178\u3001\u30d3\u30bf\u30df\u30f3B12\u3001\u30e1\u30c1\u30aa\u30cb\u30f3\uff09<\/strong><\/h3>\n\n\n\n<p>DNA\u30e1\u30c1\u30eb\u5316\u306b\u5fc5\u8981\u306a\u30e1\u30c1\u30eb\u57fa\u4f9b\u4e0e\u4f53\u3092\u8c4a\u5bcc\u306b\u542b\u3080\u98df\u54c1\uff08\u8449\u9178\u3001\u30d3\u30bf\u30df\u30f3B12\u3001\u30e1\u30c1\u30aa\u30cb\u30f3\u306a\u3069\uff09\u306f\u3001\u9aa8\u5bc6\u5ea6\u306e\u7dad\u6301\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u7279\u306b\u3001\u8449\u9178\u304c\u4e0d\u8db3\u3059\u308b\u3068\u3001DNA\u30e1\u30c1\u30eb\u5316\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u3001\u9aa8\u4ee3\u8b1d\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>C. \u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3068\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9<\/strong><\/h3>\n\n\n\n<p>\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306f\u3001\u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u3084\u30de\u30a4\u30af\u30edRNA\u306e\u8abf\u7bc0\u3092\u901a\u3058\u3066\u3001\u9aa8\u5bc6\u5ea6\u3092\u7dad\u6301\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001**\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\uff08\u30d6\u30c9\u30a6\u3084\u8d64\u30ef\u30a4\u30f3\u306b\u542b\u307e\u308c\u308b\u6210\u5206\uff09**\u306f\u3001SIRT1\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u3067\u3001\u9aa8\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\u4f5c\u7528\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u7dd1\u8336\u306b\u542b\u307e\u308c\u308b**\u30ab\u30c6\u30ad\u30f3\uff08EGCG\uff09**\u306f\u3001\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\uff08HDAC\uff09\u306e\u6d3b\u6027\u3092\u6291\u5236\u3057\u3001\u9aa8\u82bd\u7d30\u80de\u306e\u5206\u5316\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3092\u6d3b\u7528\u3057\u305f\u672a\u6765\u306e\u6cbb\u7642\u6cd5<\/strong><\/h2>\n\n\n\n<p>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3092\u6a19\u7684\u3068\u3057\u305f\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u6cbb\u7642\u6cd5\u306f\u3001\u73fe\u5728\u3082\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>DNA\u30e1\u30c1\u30eb\u5316\u3092\u8abf\u6574\u3059\u308b\u85ac\u5264<\/strong>\uff08\u4f8b\uff1a\u30c7\u30e1\u30c1\u30eb\u5316\u5264\u3092\u7528\u3044\u305f\u9aa8\u5f62\u6210\u306e\u4fc3\u9032\uff09<\/li>\n\n\n\n<li><strong>\u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u3057\u305f\u6cbb\u7642\u6cd5<\/strong>\uff08\u4f8b\uff1aHDAC\u963b\u5bb3\u5264\u3092\u6d3b\u7528\u3057\u305f\u9aa8\u82bd\u7d30\u80de\u306e\u6d3b\u6027\u5316\uff09<\/li>\n\n\n\n<li><strong>\u30de\u30a4\u30af\u30edRNA\u3092\u8abf\u6574\u3059\u308b\u65b0\u898f\u6cbb\u7642\u6cd5<\/strong>\uff08\u4f8b\uff1amiR-214\u963b\u5bb3\u5264\u3092\u7528\u3044\u305f\u9aa8\u5438\u53ce\u306e\u6291\u5236\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u65b0\u3057\u3044\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u3088\u308a\u3001\u907a\u4f1d\u7684\u306b\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u4eba\u3067\u3082\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u8abf\u6574\u3092\u901a\u3058\u3066\u3001\u9aa8\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30db\u30eb\u30e2\u30f3\u3068\u907a\u4f1d\u5b50\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u9aa8\u5bc6\u5ea6\u306b\u53ca\u307c\u3059\u5f71\u97ff<\/strong><\/h2>\n\n\n\n<p>\u9aa8\u5bc6\u5ea6\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3060\u3051\u3067\u306a\u304f\u3001\u30db\u30eb\u30e2\u30f3\u306e\u5f71\u97ff\u3092\u5927\u304d\u304f\u53d7\u3051\u307e\u3059\u3002\u7279\u306b\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3001\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u3001\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\uff08PTH\uff09\u3001\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306a\u3069\u304c\u9aa8\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u30db\u30eb\u30e2\u30f3\u3068\u907a\u4f1d\u5b50\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u5de6\u53f3\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>A. \u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\u907a\u4f1d\u5b50\uff08ESR1, ESR2\uff09\u3068\u9aa8\u5bc6\u5ea6<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/39742_m-1024x683.jpg\" alt=\"\n\uff24\uff2e\uff21\uff14\uff15\" class=\"wp-image-8664\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39742_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39742_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39742_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39742_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39742_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306f\u3001\u9aa8\u5438\u53ce\u3092\u6291\u3048\u3001\u9aa8\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308a\u3001\u9589\u7d4c\u5f8c\u306e\u5973\u6027\u306b\u304a\u3051\u308b\u9aa8\u5bc6\u5ea6\u4f4e\u4e0b\u306e\u4e3b\u306a\u539f\u56e0\u306f\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u6e1b\u5c11\u3067\u3059\u3002\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\uff08ER\uff09\u306f\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u7d30\u80de\u5185\u306b\u4f1d\u9054\u3059\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u3001ER\u306e\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u907a\u4f1d\u5b50\u5909\u7570\u304c\u9aa8\u5bc6\u5ea6\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ESR1\u907a\u4f1d\u5b50\u306e\u591a\u578b<\/strong>\uff08\u4f8b\uff1aPvuII\u3001XbaI\uff09\u306f\u3001\u9aa8\u5bc6\u5ea6\u3084\u9aa8\u6298\u30ea\u30b9\u30af\u3068\u95a2\u9023\u304c\u3042\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>ESR2\u907a\u4f1d\u5b50<\/strong>\u306e\u591a\u578b\u3082\u3001\u7279\u306b\u9589\u7d4c\u5f8c\u5973\u6027\u306e\u9aa8\u5bc6\u5ea6\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u30ea\u30b9\u30af\u306b\u95a2\u4e0e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\u306e\u907a\u4f1d\u7684\u5909\u7570\u306b\u3088\u308a\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u7642\u6cd5\u306e\u52b9\u679c\u304c\u500b\u4eba\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u5c06\u6765\u7684\u306b\u306f\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u7528\u3044\u3066\u6700\u9069\u306a\u30db\u30eb\u30e2\u30f3\u88dc\u5145\u7642\u6cd5\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>B. \u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3068\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\uff08AR\uff09\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u7537\u6027\u306b\u304a\u3044\u3066\u3082\u9aa8\u5bc6\u5ea6\u306f\u52a0\u9f62\u3068\u3068\u3082\u306b\u4f4e\u4e0b\u3057\u307e\u3059\u304c\u3001\u3053\u308c\u306f\u4e3b\u306b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u6e1b\u5c11\u306b\u3088\u308b\u3082\u306e\u3067\u3059\u3002\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306f\u3001\u76f4\u63a5\u7684\u306b\u9aa8\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306b\u5909\u63db\u3055\u308c\u308b\u3053\u3068\u3067\u9aa8\u5bc6\u5ea6\u3092\u7dad\u6301\u3059\u308b\u50cd\u304d\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\uff08AR\uff09\u907a\u4f1d\u5b50\u306eCAG\u30ea\u30d4\u30fc\u30c8\u591a\u578b<\/strong>\u304c\u3001\u9aa8\u5bc6\u5ea6\u3084\u9aa8\u6298\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002CAG\u30ea\u30d4\u30fc\u30c8\u304c\u9577\u3044\u307b\u3069\u3001\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\u306e\u611f\u53d7\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u304f\u306a\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-0a99ff83-7fff-914c-7a6c-ee00615fbb98\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>C. \u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u3068\u9aa8\u5bc6\u5ea6<\/strong><\/h3>\n\n\n\n<p>\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\uff08T3, T4\uff09\u306f\u3001\u9aa8\u4ee3\u8b1d\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u7279\u306b\u3001\u7532\u72b6\u817a\u6a5f\u80fd\u4ea2\u9032\u75c7\uff08\u30d0\u30bb\u30c9\u30a6\u75c5\uff09\u3067\u306f\u9aa8\u5438\u53ce\u304c\u904e\u5270\u306b\u9032\u884c\u3057\u3001\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u53d7\u5bb9\u4f53\uff08THRA, THRB\uff09\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong>\u304c\u3001\u9aa8\u5bc6\u5ea6\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u304f\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>D. \u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\uff08PTH\uff09\u3068\u30ab\u30eb\u30b7\u30a6\u30e0\u4ee3\u8b1d\u95a2\u9023\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\uff08PTH\uff09\u306f\u3001\u8840\u4e2d\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u3092\u8abf\u7bc0\u3057\u3001\u9aa8\u5438\u53ce\u3092\u4fc3\u9032\u3059\u308b\u30db\u30eb\u30e2\u30f3\u3067\u3059\u3002PTH\u306e\u50cd\u304d\u304c\u904e\u5270\u306b\u306a\u308b\u3068\u3001\u9aa8\u5438\u53ce\u304c\u9032\u307f\u3001\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u4e0b\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PTH\u53d7\u5bb9\u4f53\uff08PTH1R\uff09\u907a\u4f1d\u5b50\u306e\u591a\u578b<\/strong>\u306f\u3001\u9aa8\u5bc6\u5ea6\u3084\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>**\u30ab\u30eb\u30b7\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u95a2\u9023\u907a\u4f1d\u5b50\uff08CACNA1S\uff09**\u3082\u3001\u9aa8\u5bc6\u5ea6\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p>PTH\u306e\u907a\u4f1d\u7684\u5f71\u97ff\u3092\u8003\u616e\u3057\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306b\u5bfe\u3057\u3066\u9069\u5207\u306a\u30ab\u30eb\u30b7\u30a6\u30e0\u30fb\u30d3\u30bf\u30df\u30f3D\u88dc\u5145\u7642\u6cd5\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u304c\u3001\u5c06\u6765\u7684\u306a\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u4e88\u9632\u306b\u5f79\u7acb\u3064\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>E. \u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\uff08\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\uff09\u3068\u9aa8\u5bc6\u5ea6<\/strong><\/h3>\n\n\n\n<p>\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306f\u3001\u6162\u6027\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u5206\u6ccc\u3055\u308c\u308b\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308a\u3001\u9577\u671f\u9593\u306b\u308f\u305f\u308b\u9ad8\u30ec\u30d9\u30eb\u306e\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306f\u9aa8\u5bc6\u5ea6\u3092\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002\u30af\u30c3\u30b7\u30f3\u30b0\u75c7\u5019\u7fa4\u306a\u3069\u306e\u75be\u60a3\u3067\u306f\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u304c\u9ad8\u983b\u5ea6\u3067\u767a\u751f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u53d7\u5bb9\u4f53\uff08NR3C1\uff09\u907a\u4f1d\u5b50\u306e\u591a\u578b<\/strong>\u306f\u3001\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306e\u5f71\u97ff\u3092\u5f37\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u3053\u308c\u304c\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u8981\u56e0\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u6b21\u4e16\u4ee3\u306e\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u4e88\u9632\u3068\u6cbb\u7642\u6226\u7565<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/4838856_m-1024x683.jpg\" alt=\"\u62b1\u304d\u5408\u3046\u5973\u6027\" class=\"wp-image-8093\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4838856_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4838856_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4838856_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4838856_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4838856_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u65b0\u3057\u3044\u6cbb\u7642\u6226\u7565\u306f\u3001\u3088\u308a\u500b\u5225\u5316\u3055\u308c\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u53ef\u80fd\u306b\u3057\u307e\u3059\u3002\u3053\u3053\u3067\u306f\u3001\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u3068\u533b\u7642\u306e\u9032\u6b69\u304c\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u8aac\u660e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>A. \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306e\u5fdc\u7528<\/strong><\/h3>\n\n\n\n<p>CRISPR-Cas9\u306a\u3069\u306e\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u5909\u7570\u3092\u4fee\u6b63\u3059\u308b\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001<strong>COL1A1\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong>\u304c\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3092\u5f15\u304d\u8d77\u3053\u3059\u5834\u5408\u3001\u3053\u306e\u907a\u4f1d\u5b50\u3092\u4fee\u6b63\u3059\u308b\u3053\u3068\u3067\u9aa8\u306e\u5f37\u5ea6\u3092\u5411\u4e0a\u3055\u305b\u308b\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>B. \u907a\u4f1d\u5b50\u30ef\u30af\u30c1\u30f3\u306b\u3088\u308b\u9aa8\u5f62\u6210\u4fc3\u9032<\/strong><\/h3>\n\n\n\n<p>\u73fe\u5728\u306emRNA\u30ef\u30af\u30c1\u30f3\u6280\u8853\u3092\u5fdc\u7528\u3057\u3001\u9aa8\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\u907a\u4f1d\u5b50\u3092\u4e00\u6642\u7684\u306b\u767a\u73fe\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u9aa8\u5bc6\u5ea6\u3092\u5897\u52a0\u3055\u305b\u308b\u8a66\u307f\u304c\u691c\u8a0e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001<strong>RUNX2\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5897\u52a0\u3055\u305b\u308bmRNA\u30ef\u30af\u30c1\u30f3<\/strong>\u304c\u958b\u767a\u3055\u308c\u308c\u3070\u3001\u9aa8\u82bd\u7d30\u80de\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>C. AI\u3092\u6d3b\u7528\u3057\u305f\u907a\u4f1d\u5b50\u8a3a\u65ad\u3068\u6cbb\u7642\u8a08\u753b<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/4038498_m-1024x683.jpg\" alt=\"\u5973\u6027\u533b\u5e2b\" class=\"wp-image-4640\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4038498_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4038498_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4038498_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4038498_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4038498_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>AI\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u89e3\u6790\u306b\u3088\u308a\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3057\u3001\u6700\u9069\u306a\u6cbb\u7642\u6cd5\u3092\u500b\u3005\u306e\u60a3\u8005\u306b\u63d0\u4f9b\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>AI\u304c<strong>\u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u3068\u751f\u6d3b\u7fd2\u6163\u30c7\u30fc\u30bf\u3092\u7d71\u5408<\/strong>\u3057\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u4e88\u9632\u7b56\u3092\u63d0\u6848\u3002<\/li>\n\n\n\n<li>\u907a\u4f1d\u5b50\u5909\u7570\u306e\u7a2e\u985e\u306b\u5fdc\u3058\u305f<strong>\u30ab\u30b9\u30bf\u30de\u30a4\u30ba\u6cbb\u7642\u30d7\u30e9\u30f3<\/strong>\u306e\u63d0\u4f9b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001<strong>ACTN3\u907a\u4f1d\u5b50\u306e\u591a\u578b<\/strong>\u304c\u9aa8\u5bc6\u5ea6\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u5834\u5408\u3001\u305d\u306e\u60c5\u5831\u3092\u3082\u3068\u306b\u3001\u6700\u9069\u306a\u904b\u52d5\u30d7\u30ed\u30b0\u30e9\u30e0\u3084\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u6442\u53d6\u91cf\u3092\u81ea\u52d5\u3067\u63d0\u6848\u3059\u308bAI\u30b7\u30b9\u30c6\u30e0\u304c\u958b\u767a\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p><strong>\u307e\u3068\u3081<\/strong><\/p>\n\n\n\n<p>\u9aa8\u5bc6\u5ea6\u3084\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u30ea\u30b9\u30af\u306b\u306f\u907a\u4f1d\u7684\u8981\u56e0\u304c\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001<strong>VDR\u3001COL1A1\u3001ESR1\u3001LRP5<\/strong> \u306a\u3069\u306e\u907a\u4f1d\u5b50\u304c\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3084\u30db\u30eb\u30e2\u30f3\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3082\u9aa8\u4ee3\u8b1d\u3092\u5de6\u53f3\u3059\u308b\u91cd\u8981\u306a\u8981\u7d20\u3067\u3059\u3002\u8fd1\u5e74\u3067\u306f\u3001<strong>CRISPR-Cas9\u306b\u3088\u308b\u907a\u4f1d\u5b50\u7de8\u96c6\u3001AI\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u533b\u7642\u30013D\u30d0\u30a4\u30aa\u30d7\u30ea\u30f3\u30c6\u30a3\u30f3\u30b0<\/strong> \u306a\u3069\u306e\u6280\u8853\u304c\u767a\u5c55\u3057\u3001\u3088\u308a\u7cbe\u5bc6\u306a\u6cbb\u7642\u3084\u4e88\u9632\u304c\u53ef\u80fd\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u6291\u3048\u3001\u500b\u3005\u306b\u6700\u9069\u306a\u30b1\u30a2\u3092\u63d0\u4f9b\u3059\u308b\u672a\u6765\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n<p>\u8a73\u3057\u304f\u306f <a href=\"https:\/\/www.hiro-clinic.or.jp\/gene\/clinic\/\">\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u5168\u56fd\u306e\u30af\u30ea\u30cb\u30c3\u30af\u4e00\u89a7<\/a> \u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3084\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u767a\u75c7\u306b\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u591a\u578b\u304c\u9aa8\u5bc6\u5ea6\u3084\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u9aa8\u5bc6\u5ea6\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2\u3001\u4e3b\u8981\u306a\u95a2\u9023 [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":13894,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8646","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/8646","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=8646"}],"version-history":[{"count":3,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/8646\/revisions"}],"predecessor-version":[{"id":14068,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/8646\/revisions\/14068"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/13894"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=8646"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=8646"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=8646"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}