{"id":8870,"date":"2025-03-09T05:29:41","date_gmt":"2025-03-09T05:29:41","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=8870"},"modified":"2025-04-10T03:19:41","modified_gmt":"2025-04-10T03:19:41","slug":"column-sleep-gene-relationship","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/column-sleep-gene-relationship\/","title":{"rendered":"\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u7406\u60f3\u7684\u306a\u7761\u7720\u7fd2\u6163"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>1. \u907a\u4f1d\u5b50\u3068\u7761\u7720\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u7761\u7720\u306f\u3001\u4eba\u9593\u306e\u5065\u5eb7\u3068\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u4e0d\u53ef\u6b20\u306a\u751f\u7406\u7684\u30d7\u30ed\u30bb\u30b9\u3067\u3059\u304c\u3001\u305d\u306e\u8cea\u3084\u6301\u7d9a\u6642\u9593\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u9055\u3044\u306e\u591a\u304f\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u6c7a\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001<strong>CLOCK\u3001PER\u3001BMAL1\u3001ADRB1<\/strong>\u306a\u3069\u306e\u907a\u4f1d\u5b50\u304c\u3001\u7761\u7720\u30d1\u30bf\u30fc\u30f3\u3084\u6982\u65e5\u30ea\u30ba\u30e0\uff08\u4f53\u5185\u6642\u8a08\uff09\u306b\u5927\u304d\u304f\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18243156\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u500b\u4eba\u306b\u9069\u3057\u305f\u7761\u7720\u7fd2\u6163\u3092\u78ba\u7acb\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. \u4e3b\u8981\u306a\u7761\u7720\u95a2\u9023\u907a\u4f1d\u5b50\u3068\u305d\u306e\u5f71\u97ff<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) CLOCK\u907a\u4f1d\u5b50 \u2013 \u4f53\u5185\u6642\u8a08\u306e\u8abf\u6574<\/strong><\/h3>\n\n\n\n<p>CLOCK\uff08Circadian Locomotor Output Cycles Kaput\uff09\u907a\u4f1d\u5b50\u306f\u3001<strong>\u4f53\u5185\u6642\u8a08\u306e\u30ea\u30ba\u30e0\u3092\u8abf\u7bc0<\/strong>\u3057\u3001\u7761\u7720\u6642\u9593\u3084\u7761\u7720\u306e\u8cea\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs1801260\u306eC\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u591c\u578b\u50be\u5411\u304c\u5f37\u304f\u306a\u308b<\/li>\n\n\n\n<li>\u7761\u7720\u306e\u8cea\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u4e0d\u898f\u5247\u306a\u7761\u7720\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u306b\u3088\u308b\u5065\u5eb7\u30ea\u30b9\u30af\u304c\u5897\u52a0<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u4e00\u5b9a\u306e\u6642\u9593\u306b\u5c31\u5bdd\u30fb\u8d77\u5e8a\u3059\u308b\u3053\u3068\u3067\u3001\u4f53\u5185\u30ea\u30ba\u30e0\u3092\u6574\u3048\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20663212\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) PER\u907a\u4f1d\u5b50 \u2013 \u7761\u7720\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3092\u6c7a\u5b9a<\/strong><\/h3>\n\n\n\n<p>PER\uff08Period\uff09\u907a\u4f1d\u5b50\u306f\u3001<strong>\u7761\u7720\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3084\u6982\u65e5\u30ea\u30ba\u30e0\u306e\u7dad\u6301<\/strong>\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PER3\u907a\u4f1d\u5b50\u306e\u591a\u578b\uff08\u4f8b: rs57875989\uff09<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u9577\u578b\uff085\/5\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u65e9\u5bdd\u65e9\u8d77\u304d\u306e\u50be\u5411<\/li>\n\n\n\n<li>\u77ed\u578b\uff084\/4\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u591c\u578b\u306b\u306a\u308a\u3084\u3059\u304f\u3001\u7761\u7720\u4e0d\u8db3\u306b\u9665\u308a\u3084\u3059\u3044<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>PER3\u77ed\u578b\u306e\u4eba\u306f\u3001\u671d\u65e9\u304f\u8d77\u304d\u308b\u5fc5\u8981\u304c\u3042\u308b\u5834\u5408\u3001\u5c31\u5bdd\u6642\u9593\u3092\u610f\u8b58\u7684\u306b\u65e9\u3081\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12841365\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(3) BMAL1\u907a\u4f1d\u5b50 \u2013 \u30e1\u30e9\u30c8\u30cb\u30f3\u5206\u6ccc\u306e\u8abf\u6574<\/strong><\/h3>\n\n\n\n<p>BMAL1\uff08Brain and Muscle ARNT-Like 1\uff09\u907a\u4f1d\u5b50\u306f\u3001<strong>\u30e1\u30e9\u30c8\u30cb\u30f3\uff08\u7761\u7720\u30db\u30eb\u30e2\u30f3\uff09\u306e\u5206\u6ccc\u3092\u5236\u5fa1<\/strong>\u3057\u3001\u6982\u65e5\u30ea\u30ba\u30e0\u3092\u7dad\u6301\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>BMAL1\u907a\u4f1d\u5b50\u306e\u5909\u7570\uff08\u4f8b: rs2278749\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30e1\u30e9\u30c8\u30cb\u30f3\u306e\u5206\u6ccc\u304c\u9045\u308c\u3084\u3059\u304f\u3001\u591c\u66f4\u304b\u3057\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u7761\u7720\u306e\u8cea\u304c\u4f4e\u4e0b\u3057\u3001\u65e5\u4e2d\u306e\u7720\u6c17\u304c\u5897\u52a0<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>BMAL1\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u5915\u65b9\u4ee5\u964d\u306e\u5f37\u3044\u5149\uff08\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\uff09\u3092\u907f\u3051\u308b\u3053\u3068\u3067\u30e1\u30e9\u30c8\u30cb\u30f3\u5206\u6ccc\u3092\u6b63\u5e38\u5316<\/strong>\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22286106\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u907a\u4f1d\u5b50\u30bf\u30a4\u30d7\u5225\u306e\u6700\u9069\u306a\u7761\u7720\u7fd2\u6163<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"724\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/2469840_m-1024x724.jpg\" alt=\"\" class=\"wp-image-8498\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2469840_m-1024x724.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2469840_m-300x212.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2469840_m-768x543.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2469840_m-1536x1086.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2469840_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) \u591c\u578b\u50be\u5411\u306e\u5f37\u3044\u4eba\u5411\u3051\u306e\u5bfe\u7b56<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u95a2\u9023\u907a\u4f1d\u5b50:<\/strong> CLOCK, PER3\u77ed\u578b, BMAL1\u5909\u7570<\/li>\n\n\n\n<li><strong>\u63a8\u5968\u3055\u308c\u308b\u7fd2\u6163:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u671d\u8d77\u304d\u305f\u3089\u3059\u3050\u306b\u592a\u967d\u5149\u3092\u6d74\u3073\u3001\u4f53\u5185\u6642\u8a08\u3092\u30ea\u30bb\u30c3\u30c8<\/li>\n\n\n\n<li>\u5915\u65b9\u4ee5\u964d\u306f\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\uff08\u30b9\u30de\u30db\u30fbPC\uff09\u3092\u907f\u3051\u308b<\/li>\n\n\n\n<li>\u30e1\u30e9\u30c8\u30cb\u30f3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u9069\u5207\u306b\u4f7f\u7528\u3059\u308b<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) \u65e9\u5bdd\u65e9\u8d77\u304d\u304c\u5f97\u610f\u306a\u4eba\u5411\u3051\u306e\u6ce8\u610f\u70b9<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u95a2\u9023\u907a\u4f1d\u5b50:<\/strong> PER3\u9577\u578b, ADRB1<\/li>\n\n\n\n<li><strong>\u63a8\u5968\u3055\u308c\u308b\u7fd2\u6163:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u591c\u9045\u304f\u307e\u3067\u6d3b\u52d5\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u65e5\u306f\u3001\u77ed\u3044\u663c\u5bdd\u3092\u53d6\u308a\u5165\u308c\u308b<\/li>\n\n\n\n<li>\u30ab\u30d5\u30a7\u30a4\u30f3\u306e\u6442\u53d6\u3092\u5348\u5f8c\u4ee5\u964d\u63a7\u3048\u308b<\/li>\n\n\n\n<li>\u5c31\u5bdd1\u6642\u9593\u524d\u306b\u30ea\u30e9\u30c3\u30af\u30b9\u3067\u304d\u308b\u30eb\u30fc\u30c1\u30f3\u3092\u4f5c\u308b<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>4. \u7761\u7720\u306e\u8cea\u3092\u5411\u4e0a\u3055\u305b\u308b\u907a\u4f1d\u5b50\u306b\u57fa\u3065\u3044\u305f\u6804\u990a\u6226\u7565<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) \u30e1\u30e9\u30c8\u30cb\u30f3\u751f\u6210\u3092\u4fc3\u9032\u3059\u308b\u6804\u990a\u7d20<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3\uff08\u30e1\u30e9\u30c8\u30cb\u30f3\u306e\u524d\u99c6\u4f53\uff09\u3092\u542b\u3080\u98df\u54c1<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30d0\u30ca\u30ca\u3001\u4e73\u88fd\u54c1\u3001\u30ca\u30c3\u30c4\u985e<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\uff08\u7761\u7720\u3092\u6df1\u3081\u308b\uff09\u3092\u542b\u3080\u98df\u54c1<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u307b\u3046\u308c\u3093\u8349\u3001\u30a2\u30fc\u30e2\u30f3\u30c9\u3001\u30ab\u30dc\u30c1\u30e3\u306e\u7a2e<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) \u7761\u7720\u3092\u59a8\u3052\u308b\u98df\u54c1\u306e\u56de\u907f<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ab\u30d5\u30a7\u30a4\u30f3<\/strong> \u2192 \u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u4ee3\u8b1d\u901f\u5ea6\u304c\u7570\u306a\u308b\u305f\u3081\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u611f\u53d7\u6027\u304c\u9ad8\u3044\u4eba\u306f\u6442\u53d6\u3092\u5236\u9650<\/li>\n\n\n\n<li><strong>\u30a2\u30eb\u30b3\u30fc\u30eb<\/strong> \u2192 \u7761\u7720\u306e\u8cea\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u305f\u3081\u3001\u5bdd\u308b\u524d\u306e\u98f2\u9152\u3092\u63a7\u3048\u308b<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>5. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u6700\u65b0\u306e\u7761\u7720\u7814\u7a76<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"724\" src=\"\/gene\/wp-content\/uploads\/2025\/02\/3970581_m-1024x724.jpg\" alt=\"\" class=\"wp-image-6526\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/3970581_m-1024x724.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/3970581_m-300x212.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/3970581_m-768x543.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/3970581_m-1536x1086.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/3970581_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8fd1\u5e74\u3001\u907a\u4f1d\u5b50\u3068\u7761\u7720\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u304c\u9032\u307f\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u7761\u7720\u6539\u5584\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AI\u3092\u6d3b\u7528\u3057\u305f\u907a\u4f1d\u5b50\u30d9\u30fc\u30b9\u306e\u7761\u7720\u8a3a\u65ad<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u691c\u67fb\u3068\u7761\u7720\u30c8\u30e9\u30c3\u30ad\u30f3\u30b0\u30c7\u30fc\u30bf\u3092\u7d44\u307f\u5408\u308f\u305b\u3001\u500b\u5225\u6700\u9069\u5316\u3055\u308c\u305f\u7761\u7720\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u3092\u63d0\u6848<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\uff08CRISPR\uff09\u306b\u3088\u308b\u7761\u7720\u969c\u5bb3\u306e\u6cbb\u7642<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7761\u7720\u969c\u5bb3\u306e\u539f\u56e0\u3068\u306a\u308b\u907a\u4f1d\u5b50\u5909\u7570\u3092\u4fee\u6b63\u3057\u3001\u6982\u65e5\u30ea\u30ba\u30e0\u3092\u6b63\u5e38\u5316<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32193329\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6. \u4eca\u5f8c\u306e\u5c55\u671b<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u500b\u4eba\u306e\u907a\u4f1d\u7684\u7279\u6027\u306b\u57fa\u3065\u3044\u305f\u7761\u7720\u6700\u9069\u5316\u304c\u53ef\u80fd\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u4eca\u5f8c\u3001\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u305f\u7761\u7720\u6539\u5584\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u4e00\u822c\u5316\u3057\u3001\u4e00\u4eba\u3072\u3068\u308a\u306b\u6700\u9069\u306a\u7761\u7720\u6226\u7565\u3092\u63d0\u6848\u3059\u308b\u6642\u4ee3\u304c\u5230\u6765\u3059\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>7. \u7761\u7720\u969c\u5bb3\u3068\u907a\u4f1d\u7684\u8981\u56e0\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u7761\u7720\u306e\u8cea\u3084\u6301\u7d9a\u6642\u9593\u3060\u3051\u3067\u306a\u304f\u3001\u4e0d\u7720\u75c7\u3084\u904e\u7720\u75c7\u3068\u3044\u3063\u305f\u7761\u7720\u969c\u5bb3\u306b\u3082\u907a\u4f1d\u7684\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) \u4e0d\u7720\u75c7\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u4e0d\u7720\u75c7\u306f\u3001\u5165\u7720\u56f0\u96e3\u30fb\u9014\u4e2d\u899a\u9192\u30fb\u65e9\u671d\u899a\u9192\u306a\u3069\u306e\u75c7\u72b6\u3092\u7279\u5fb4\u3068\u3059\u308b\u7761\u7720\u969c\u5bb3\u3067\u3059\u3002\u74b0\u5883\u8981\u56e0\uff08\u30b9\u30c8\u30ec\u30b9\u3001\u751f\u6d3b\u7fd2\u6163\u306a\u3069\uff09\u304c\u5927\u304d\u304f\u5f71\u97ff\u3057\u307e\u3059\u304c\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3082\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>HCRTR1\u907a\u4f1d\u5b50\u3068\u4e0d\u7720\u75c7<\/strong><\/h4>\n\n\n\n<p>HCRTR1\uff08\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f531\uff09\u907a\u4f1d\u5b50\u306f\u3001\u899a\u9192\u3092\u7dad\u6301\u3059\u308b\u30aa\u30ec\u30ad\u30b7\u30f3\u3068\u3044\u3046\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3068\u95a2\u4fc2\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs2271933\u306eT\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u899a\u9192\u72b6\u614b\u304c\u6301\u7d9a\u3057\u3084\u3059\u304f\u3001\u5165\u7720\u56f0\u96e3\u306b\u306a\u308a\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u53cd\u5fdc\u304c\u5f37\u304f\u3001\u4e0d\u7720\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b<\/li>\n\n\n\n<li>\u9577\u671f\u7684\u306a\u4e0d\u7720\u306b\u3088\u308a\u3001\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306e\u554f\u984c\uff08\u4e0d\u5b89\u75c7\u3001\u3046\u3064\u75c5\uff09\u3092\u767a\u75c7\u3057\u3084\u3059\u3044<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u5c31\u5bdd\u524d\u306b\u30ea\u30e9\u30c3\u30af\u30b9\u3059\u308b\u7fd2\u6163\u3092\u6301\u3061\u3001\u30aa\u30ec\u30ad\u30b7\u30f3\u306e\u6d3b\u6027\u3092\u6291\u3048\u308b\u98df\u4e8b\uff08\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u3084GABA\u3092\u542b\u3080\u98df\u54c1\uff09\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u304c\u63a8\u5968<\/strong>\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19118042\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>GABRB3\u907a\u4f1d\u5b50\u3068\u7761\u7720\u306e\u5b89\u5b9a\u6027<\/strong><\/h4>\n\n\n\n<p>GABRB3\uff08\u03b3\u30a2\u30df\u30ce\u916a\u9178\u53d7\u5bb9\u4f53B3\uff09\u907a\u4f1d\u5b50\u306f\u3001GABA\u3068\u3044\u3046\u30ea\u30e9\u30c3\u30af\u30b9\u3092\u4fc3\u9032\u3059\u308b\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u53d7\u5bb9\u4f53\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs4906902\u306eC\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>GABA\u306e\u4f5c\u7528\u304c\u5f31\u307e\u308a\u3001\u795e\u7d4c\u306e\u8208\u596e\u304c\u7d9a\u304d\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u7761\u7720\u306e\u9014\u4e2d\u3067\u899a\u9192\u3057\u3084\u3059\u304f\u3001\u6df1\u3044\u7761\u7720\u3092\u7dad\u6301\u3057\u306b\u304f\u3044<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001<strong>GABA\u3092\u591a\u304f\u542b\u3080\u98df\u54c1\uff08\u767a\u9175\u98df\u54c1\u3001\u30c8\u30de\u30c8\u3001\u307b\u3046\u308c\u3093\u8349\uff09\u3092\u6442\u53d6\u3057\u3001\u526f\u4ea4\u611f\u795e\u7d4c\u3092\u512a\u4f4d\u306b\u3059\u308b\u7fd2\u6163\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u304c\u6709\u52b9<\/strong>\u3067\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15637625\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) \u904e\u7720\u75c7\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u904e\u7720\u75c7\u306f\u3001\u65e5\u4e2d\u306e\u5f37\u3044\u7720\u6c17\u3084\u9577\u6642\u9593\u306e\u7761\u7720\u304c\u7279\u5fb4\u7684\u306a\u7761\u7720\u969c\u5bb3\u3067\u3059\u3002\u7279\u306b\u3001\u30ca\u30eb\u30b3\u30ec\u30d7\u30b7\u30fc\u3068\u547c\u3070\u308c\u308b\u75be\u60a3\u306f\u907a\u4f1d\u7684\u8981\u56e0\u306e\u5f71\u97ff\u3092\u5f37\u304f\u53d7\u3051\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>HLA-DQB1\u907a\u4f1d\u5b50\u3068\u30ca\u30eb\u30b3\u30ec\u30d7\u30b7\u30fc<\/strong><\/h4>\n\n\n\n<p>HLA-DQB1\u907a\u4f1d\u5b50\u306f\u3001\u514d\u75ab\u7cfb\u3068\u7761\u7720\u5236\u5fa1\u306b\u95a2\u4e0e\u3057\u3001\u30ca\u30eb\u30b3\u30ec\u30d7\u30b7\u30fc\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: HLA-DQB1*06:02\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30aa\u30ec\u30ad\u30b7\u30f3\uff08\u899a\u9192\u3092\u7dad\u6301\u3059\u308b\u30db\u30eb\u30e2\u30f3\uff09\u306e\u5206\u6ccc\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u65e5\u4e2d\u306b\u6025\u6fc0\u306a\u7720\u6c17\u304c\u767a\u751f\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u7761\u7720\u306e\u8cea\u304c\u60aa\u5316\u3057\u3001\u75b2\u52b4\u611f\u304c\u629c\u3051\u306b\u304f\u3044<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u898f\u5247\u6b63\u3057\u3044\u7761\u7720\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u3092\u5b88\u308b\u3053\u3068\u304c\u7279\u306b\u91cd\u8981\u3067\u3042\u308a\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u5c02\u9580\u533b\u306e\u8a3a\u5bdf\u3092\u53d7\u3051\u308b\u3079\u304d<\/strong>\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10762543\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>PER2\u907a\u4f1d\u5b50\u3068\u904e\u7720\u75c7<\/strong><\/h4>\n\n\n\n<p>PER2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u6982\u65e5\u30ea\u30ba\u30e0\u306e\u8abf\u6574\u4e0d\u5168\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u904e\u7720\u75c7\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs2304672\u306eA\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4f53\u5185\u6642\u8a08\u306e\u4e71\u308c\u306b\u3088\u308a\u3001\u7761\u7720\u6642\u9593\u304c\u9577\u304f\u306a\u308b\u50be\u5411<\/li>\n\n\n\n<li>\u671d\u306e\u899a\u9192\u304c\u56f0\u96e3\u306b\u306a\u308a\u3001\u904e\u7720\u75c7\u306e\u30ea\u30b9\u30af\u304c\u4e0a\u6607<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u671d\u8d77\u304d\u305f\u3089\u3059\u3050\u306b\u65e5\u5149\u3092\u6d74\u3073\u3001\u4f53\u5185\u6642\u8a08\u3092\u30ea\u30bb\u30c3\u30c8\u3059\u308b\u7fd2\u6163\u3092\u6301\u3064\u3053\u3068\u304c\u63a8\u5968<\/strong>\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20663212\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>8. \u7761\u7720\u6539\u5584\u306b\u5f79\u7acb\u3064\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/31831804_m-1024x683.jpg\" alt=\"\u85ac\u3068\u6c34\" class=\"wp-image-8601\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31831804_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31831804_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31831804_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31831804_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31831804_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) \u30e1\u30e9\u30c8\u30cb\u30f3\u88dc\u5145\u306e\u5fc5\u8981\u6027<\/strong><\/h3>\n\n\n\n<p>\u30e1\u30e9\u30c8\u30cb\u30f3\u306f\u7761\u7720\u3092\u4fc3\u9032\u3059\u308b\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308a\u3001\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u5206\u6ccc\u91cf\u306b\u500b\u4eba\u5dee\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>BMAL1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30e1\u30e9\u30c8\u30cb\u30f3\u306e\u5206\u6ccc\u304c\u9045\u308c\u3084\u3059\u3044 \u2192 <strong>\u5bdd\u308b\u524d\u306b\u30e1\u30e9\u30c8\u30cb\u30f3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u7761\u7720\u30ea\u30ba\u30e0\u3092\u8abf\u6574<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22286106\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) \u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u3068GABA\u306e\u88dc\u5145<\/strong><\/h3>\n\n\n\n<p>\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u3068GABA\u306f\u30ea\u30e9\u30c3\u30af\u30b9\u52b9\u679c\u3092\u6301\u3061\u3001\u4e0d\u7720\u75c7\u306e\u6539\u5584\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>GABRB3\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u795e\u7d4c\u306e\u8208\u596e\u304c\u7d9a\u304d\u3084\u3059\u3044 \u2192 <strong>GABA\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u6442\u53d6\u3057\u3001\u526f\u4ea4\u611f\u795e\u7d4c\u3092\u512a\u4f4d\u306b\u3059\u308b<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15637625\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PER2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u898f\u5247\u6b63\u3057\u3044\u7761\u7720\u304c\u96e3\u3057\u3044 \u2192 <strong>\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u3092\u6442\u53d6\u3057\u3001\u7761\u7720\u306e\u5b89\u5b9a\u6027\u3092\u5411\u4e0a<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19118042\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>9. \u907a\u4f1d\u5b50\u3092\u6d3b\u7528\u3057\u305f\u672a\u6765\u306e\u7761\u7720\u7ba1\u7406\u6280\u8853<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) \u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3068\u30b9\u30de\u30fc\u30c8\u30c7\u30d0\u30a4\u30b9\u306e\u7d71\u5408<\/strong><\/h3>\n\n\n\n<p>\u73fe\u5728\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3068\u30a6\u30a7\u30a2\u30e9\u30d6\u30eb\u30c7\u30d0\u30a4\u30b9\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u7761\u7720\u7ba1\u7406\u30b7\u30b9\u30c6\u30e0\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u3082\u3068\u306b\u6700\u9069\u306a\u5c31\u5bdd\u30fb\u8d77\u5e8a\u6642\u9593\u3092\u63d0\u6848<\/li>\n\n\n\n<li>\u30b9\u30de\u30fc\u30c8\u30a6\u30a9\u30c3\u30c1\u3068\u9023\u643a\u3057\u3001\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u7761\u7720\u306e\u8cea\u3092\u89e3\u6790<\/li>\n<\/ul>\n\n\n\n<p>\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32193329\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306b\u3088\u308b\u7761\u7720\u969c\u5bb3\u306e\u6cbb\u7642<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CRISPR\u6280\u8853\u3092\u5229\u7528\u3057\u305f\u6982\u65e5\u30ea\u30ba\u30e0\u306e\u8abf\u6574<\/strong><\/li>\n\n\n\n<li><strong>\u7761\u7720\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u3092\u4fee\u6b63\u3057\u3001\u7761\u7720\u969c\u5bb3\u306e\u6839\u672c\u6cbb\u7642\u3092\u76ee\u6307\u3059<\/strong><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6280\u8853\u306f\u3001\u5c06\u6765\u7684\u306b\u7761\u7720\u306e\u8cea\u3092\u6839\u672c\u7684\u306b\u6539\u5584\u3059\u308b\u624b\u6bb5\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>10. \u907a\u4f1d\u5b50\u3068\u52a0\u9f62\u306b\u3088\u308b\u7761\u7720\u306e\u5909\u5316<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31250640_m-1024x683.jpg\" alt=\"\" class=\"wp-image-8899\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31250640_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31250640_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31250640_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31250640_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31250640_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u52a0\u9f62\u3068\u3068\u3082\u306b\u7761\u7720\u30d1\u30bf\u30fc\u30f3\u304c\u5909\u5316\u3059\u308b\u3053\u3068\u306f\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u8981\u56e0\u306e\u4e00\u90e8\u306f\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u6c7a\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) \u7761\u7720\u306e\u77ed\u7e2e\u3068\u907a\u4f1d\u5b50\u306e\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<p>\u5e74\u9f62\u3092\u91cd\u306d\u308b\u3068\u3001\u6df1\u3044\u7761\u7720\uff08\u5f90\u6ce2\u7761\u7720\uff09\u306e\u6642\u9593\u304c\u6e1b\u5c11\u3057\u3001\u591c\u4e2d\u306b\u76ee\u304c\u899a\u3081\u3084\u3059\u304f\u306a\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u306f\u4ee5\u4e0b\u306e\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>DEC2\u907a\u4f1d\u5b50\u3068\u77ed\u6642\u9593\u7761\u7720<\/strong><\/h4>\n\n\n\n<p>DEC2\uff08BHLHE41\uff09\u907a\u4f1d\u5b50\u306f\u3001\u7761\u7720\u6642\u9593\u306e\u9577\u3055\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>DEC2\u306e\u5909\u7570\uff08\u4f8b: rs121912617\uff09\u3092\u6301\u3064\u4eba<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7761\u7720\u6642\u9593\u304c\u81ea\u7136\u3068\u77ed\u304f\u306a\u308b<\/li>\n\n\n\n<li>\u6df1\u3044\u7761\u7720\u306e\u6642\u9593\u304c\u6e1b\u5c11\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li>4\uff5e6\u6642\u9593\u306e\u7761\u7720\u3067\u3082\u6bd4\u8f03\u7684\u5143\u6c17\u306b\u904e\u3054\u305b\u308b<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u5e74\u9f62\u3068\u3068\u3082\u306b\u3055\u3089\u306b\u7761\u7720\u6642\u9593\u304c\u77ed\u7e2e\u3055\u308c\u308b\u50be\u5411\u304c\u3042\u308b\u305f\u3081\u3001<strong>\u65e5\u4e2d\u306e\u4eee\u7720\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u7761\u7720\u4e0d\u8db3\u3092\u88dc\u3046\u3053\u3068\u304c\u63a8\u5968<\/strong>\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19710622\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>MTNR1B\u907a\u4f1d\u5b50\u3068\u30e1\u30e9\u30c8\u30cb\u30f3\u5206\u6ccc\u306e\u4f4e\u4e0b<\/strong><\/h4>\n\n\n\n<p>MTNR1B\uff08\u30e1\u30e9\u30c8\u30cb\u30f3\u53d7\u5bb9\u4f531B\uff09\u907a\u4f1d\u5b50\u306f\u3001\u30e1\u30e9\u30c8\u30cb\u30f3\u306e\u611f\u53d7\u6027\u306b\u95a2\u4e0e\u3057\u3001\u52a0\u9f62\u306b\u3088\u308b\u7761\u7720\u306e\u8cea\u306e\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs10830963\u306eG\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30e1\u30e9\u30c8\u30cb\u30f3\u306e\u5206\u6ccc\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u304f\u3001\u5165\u7720\u56f0\u96e3\u306b\u306a\u308a\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u52a0\u9f62\u306b\u3088\u3063\u3066\u7761\u7720\u306e\u8cea\u304c\u60aa\u5316\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u591c\u9593\u306e\u899a\u9192\u304c\u5897\u52a0\u3059\u308b<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u5915\u65b9\u4ee5\u964d\u306e\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\u3092\u5236\u9650\u3057\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u30e1\u30e9\u30c8\u30cb\u30f3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u5229\u7528\u3059\u308b\u3053\u3068\u3067\u7761\u7720\u306e\u8cea\u3092\u5411\u4e0a<\/strong>\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19144937\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) \u52a0\u9f62\u3068\u6982\u65e5\u30ea\u30ba\u30e0\u306e\u5909\u5316<\/strong><\/h3>\n\n\n\n<p>\u52a0\u9f62\u3068\u3068\u3082\u306b\u3001\u671d\u578b\u306e\u50be\u5411\u304c\u5f37\u307e\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u5909\u5316\u306b\u306f\u3001PER2\u907a\u4f1d\u5b50\u3084CLOCK\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>PER2\u907a\u4f1d\u5b50\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PER2\u306e\u7279\u5b9a\u306e\u591a\u578b\uff08\u4f8b: rs2304672\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u671d\u578b\u306e\u50be\u5411\u304c\u52a0\u9f62\u3068\u3068\u3082\u306b\u5f37\u307e\u308b<\/li>\n\n\n\n<li>\u591c\u9593\u306e\u7761\u7720\u6642\u9593\u304c\u77ed\u7e2e\u3055\u308c\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u65e9\u671d\u899a\u9192\u304c\u5897\u52a0<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u591c\u9593\u306e\u7167\u660e\u3092\u6696\u8272\u7cfb\u306e\u3082\u306e\u306b\u5909\u66f4\u3057\u3001\u7761\u7720\u6642\u9593\u3092\u78ba\u4fdd\u3059\u308b\u7fd2\u6163\u3092\u6301\u3064\u3053\u3068\u304c\u63a8\u5968<\/strong>\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20663212\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>CLOCK\u907a\u4f1d\u5b50\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CLOCK\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u52a0\u9f62\u306b\u3088\u3063\u3066\u4f53\u5185\u6642\u8a08\u306e\u8abf\u6574\u304c\u96e3\u3057\u304f\u306a\u308b<\/li>\n\n\n\n<li>\u663c\u9593\u306e\u7720\u6c17\u304c\u5897\u52a0\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u591c\u9593\u306e\u30e1\u30e9\u30c8\u30cb\u30f3\u5206\u6ccc\u304c\u4f4e\u4e0b<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u5b9a\u671f\u7684\u306a\u904b\u52d5\u3068\u65e5\u5149\u6d74\u3092\u7fd2\u6163\u306b\u3059\u308b\u3053\u3068\u3067\u3001\u6982\u65e5\u30ea\u30ba\u30e0\u306e\u5909\u5316\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b<\/strong>\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18243156\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>11. \u7761\u7720\u306e\u8cea\u3092\u5411\u4e0a\u3055\u305b\u308b\u305f\u3081\u306e\u884c\u52d5\u907a\u4f1d\u5b66\u7684\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31956246_m-1024x683.jpg\" alt=\"\" class=\"wp-image-8906\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31956246_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31956246_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31956246_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31956246_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31956246_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u3068\u74b0\u5883\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u8003\u616e\u3057\u305f\u300c\u884c\u52d5\u907a\u4f1d\u5b66\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u300d\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u7761\u7720\u306e\u8cea\u3092\u6700\u5927\u9650\u306b\u9ad8\u3081\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) \u907a\u4f1d\u5b50\u306b\u57fa\u3065\u3044\u305f\u7761\u7720\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u306e\u6700\u9069\u5316<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u591c\u578b\u907a\u4f1d\u5b50\u3092\u6301\u3064\u4eba\u5411\u3051<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50: CLOCK\uff08rs1801260\uff09\u3001PER3\u77ed\u578b\uff08rs57875989\uff09<\/li>\n\n\n\n<li>\u6700\u9069\u306a\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb:\n<ul class=\"wp-block-list\">\n<li>\u5c31\u5bdd\u6642\u9593\u3092\u56fa\u5b9a\u3057\u3001\u6bce\u65e5\u540c\u3058\u6642\u9593\u306b\u8d77\u5e8a\u3059\u308b<\/li>\n\n\n\n<li>\u5915\u65b9\u4ee5\u964d\u306e\u30ab\u30d5\u30a7\u30a4\u30f3\u6442\u53d6\u3092\u907f\u3051\u308b<\/li>\n\n\n\n<li>\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\u3092\u5236\u9650\u3057\u3001\u591c\u306f\u9593\u63a5\u7167\u660e\u3092\u4f7f\u7528\u3059\u308b<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u671d\u578b\u907a\u4f1d\u5b50\u3092\u6301\u3064\u4eba\u5411\u3051<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50: PER2\uff08rs2304672\uff09\u3001PER3\u9577\u578b\uff08rs57875989\uff09<\/li>\n\n\n\n<li>\u6700\u9069\u306a\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb:\n<ul class=\"wp-block-list\">\n<li>\u671d\u306e\u65e5\u5149\u6d74\u3092\u7a4d\u6975\u7684\u306b\u884c\u3046<\/li>\n\n\n\n<li>\u5c31\u5bdd\u6642\u9593\u3092\u9045\u3089\u305b\u308b\u305f\u3081\u306b\u3001\u591c\u306b\u8efd\u3044\u904b\u52d5\u3092\u53d6\u308a\u5165\u308c\u308b<\/li>\n\n\n\n<li>\u5915\u98df\u3092\u9045\u3081\u306b\u6442\u53d6\u3057\u3001\u591c\u306e\u6d3b\u52d5\u6642\u9593\u3092\u5ef6\u3070\u3059<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) \u907a\u4f1d\u5b50\u3068\u904b\u52d5\u306e\u95a2\u4fc2\u3092\u5229\u7528\u3057\u305f\u7761\u7720\u6539\u5584<\/strong><\/h3>\n\n\n\n<p>\u904b\u52d5\u306f\u7761\u7720\u306e\u8cea\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u6700\u9069\u306a\u904b\u52d5\u306e\u7a2e\u985e\u304c\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u6301\u4e45\u529b\u7cfb\u904b\u52d5\u304c\u6709\u52b9\u306a\u907a\u4f1d\u5b50\u578b<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PPARGC1A\uff08rs8192678\uff09\u306e\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u30b8\u30e7\u30ae\u30f3\u30b0\u3084\u30b5\u30a4\u30af\u30ea\u30f3\u30b0\u304c\u52b9\u679c\u7684<\/strong><\/li>\n\n\n\n<li><strong>ACE\uff08rs1799752\uff09\u306eI\u578b\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u8efd\u3081\u306e\u6709\u9178\u7d20\u904b\u52d5\u304c\u6700\u9069<\/strong><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u6709\u52b9\u306a\u907a\u4f1d\u5b50\u578b<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ACTN3\uff08rs1815739\uff09\u306eRR\u578b\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u77ed\u6642\u9593\u306e\u9ad8\u5f37\u5ea6\u7b4b\u30c8\u30ec\u304c\u52b9\u679c\u7684<\/strong><\/li>\n\n\n\n<li><strong>MSTN\uff08rs1805086\uff09\u306e\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>\u7b4b\u80a5\u5927\u3092\u4fc3\u9032\u3059\u308b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u6709\u52b9<\/strong><\/li>\n<\/ul>\n\n\n\n<p>\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17051298\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>12. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u7761\u7720\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u53ef\u80fd\u6027<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u7761\u7720\u6700\u9069\u5316\u30d7\u30ed\u30b0\u30e9\u30e0<\/strong><\/h3>\n\n\n\n<p>\u8fd1\u5e74\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u3066\u500b\u3005\u306e\u7761\u7720\u7279\u6027\u306b\u57fa\u3065\u3044\u305f\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u63d0\u4f9b\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>DNA\u5206\u6790\u306b\u3088\u308b\u500b\u5225\u306e\u7761\u7720\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306e\u63d0\u4f9b<\/strong><\/li>\n\n\n\n<li><strong>\u30b9\u30de\u30fc\u30c8\u30a6\u30a9\u30c3\u30c1\u3084\u7761\u7720\u30c8\u30e9\u30c3\u30ab\u30fc\u3068\u306e\u7d71\u5408<\/strong><\/li>\n\n\n\n<li><strong>AI\u3092\u6d3b\u7528\u3057\u305f\u30c7\u30fc\u30bf\u89e3\u6790\u306b\u3088\u308b\u6700\u9069\u306a\u7761\u7720\u7fd2\u6163\u306e\u63d0\u6848<\/strong><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) \u907a\u4f1d\u5b50\u6cbb\u7642\u3068\u672a\u6765\u306e\u7761\u7720\u7ba1\u7406<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CRISPR\u6280\u8853\u306b\u3088\u308b\u6982\u65e5\u30ea\u30ba\u30e0\u7570\u5e38\u306e\u4fee\u6b63<\/strong><\/li>\n\n\n\n<li><strong>\u30e1\u30e9\u30c8\u30cb\u30f3\u53d7\u5bb9\u4f53\u306e\u907a\u4f1d\u5b50\u7de8\u96c6\u306b\u3088\u308b\u7761\u7720\u969c\u5bb3\u6cbb\u7642<\/strong><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6280\u8853\u304c\u767a\u5c55\u3059\u308c\u3070\u3001\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u7761\u7720\u7ba1\u7406\u304c\u53ef\u80fd\u306b\u306a\u308a\u3001\u500b\u3005\u306b\u6700\u9069\u306a\u7761\u7720\u74b0\u5883\u3092\u6574\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>13. \u7761\u7720\u3068\u514d\u75ab\u6a5f\u80fd\u306e\u95a2\u4fc2\uff1a\u907a\u4f1d\u5b50\u306b\u3088\u308b\u5f71\u97ff<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/39742_m-1024x683.jpg\" alt=\"\uff24\uff2e\uff21\uff14\uff15\" class=\"wp-image-8664\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39742_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39742_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39742_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39742_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39742_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u7761\u7720\u306f\u514d\u75ab\u6a5f\u80fd\u3068\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u7761\u7720\u306e\u8cea\u3068\u514d\u75ab\u5fdc\u7b54\u306e\u5f37\u3055\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u7814\u7a76\u306b\u3088\u3063\u3066\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) IL6\u907a\u4f1d\u5b50\u3068\u708e\u75c7\u53cd\u5fdc<\/strong><\/h3>\n\n\n\n<p>IL6\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f36\uff09\u907a\u4f1d\u5b50\u306f\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u7523\u751f\u3092\u8abf\u7bc0\u3057\u3001\u7761\u7720\u4e2d\u306e\u514d\u75ab\u6a5f\u80fd\u306e\u7dad\u6301\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs1800795\u306eG\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u708e\u75c7\u53cd\u5fdc\u304c\u904e\u5270\u306b\u306a\u308a\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u7761\u7720\u306e\u8cea\u304c\u4f4e\u4e0b\u3057\u3001\u591c\u9593\u306e\u899a\u9192\u304c\u5897\u52a0<\/li>\n\n\n\n<li>\u6162\u6027\u7684\u306a\u7761\u7720\u4e0d\u8db3\u304c\u514d\u75ab\u4f4e\u4e0b\u306b\u3064\u306a\u304c\u308b<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u6297\u708e\u75c7\u4f5c\u7528\u306e\u3042\u308b\u98df\u54c1\uff08\u30bf\u30fc\u30e1\u30ea\u30c3\u30af\u3001\u7dd1\u8336\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff09\u3092\u6442\u53d6\u3057\u3001\u7761\u7720\u4e2d\u306e\u708e\u75c7\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u91cd\u8981<\/strong>\u3067\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15059915\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) TNF\u907a\u4f1d\u5b50\u3068\u7761\u7720\u306e\u8cea<\/strong><\/h3>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p>TNF\uff08\u816b\u760d\u58ca\u6b7b\u56e0\u5b50\uff09\u907a\u4f1d\u5b50\u306f\u3001\u708e\u75c7\u5fdc\u7b54\u3068\u7761\u7720\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs1800629\u306eA\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7761\u7720\u306e\u5206\u65ad\u304c\u591a\u304f\u3001\u6df1\u3044\u7720\u308a\u304c\u77ed\u7e2e\u3055\u308c\u308b<\/li>\n\n\n\n<li>\u75b2\u52b4\u611f\u304c\u629c\u3051\u306b\u304f\u304f\u3001\u65e5\u4e2d\u306e\u7720\u6c17\u304c\u5f37\u304f\u306a\u308b<\/li>\n\n\n\n<li>\u514d\u75ab\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u98a8\u90aa\u3084\u611f\u67d3\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u3084\u898f\u5247\u7684\u306a\u7761\u7720\u7fd2\u6163\u3092\u5fb9\u5e95\u3059\u308b\u3053\u3068\u3067\u3001\u514d\u75ab\u529b\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u304c\u63a8\u5968<\/strong>\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12604798\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>14. \u7761\u7720\u3068\u8a8d\u77e5\u6a5f\u80fd\uff1a\u907a\u4f1d\u5b50\u306e\u5f71\u97ff<\/strong><\/h2>\n\n\n\n<p>\u7761\u7720\u306e\u8cea\u306f\u8a8d\u77e5\u6a5f\u80fd\u306b\u3082\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u8a18\u61b6\u529b\u3084\u96c6\u4e2d\u529b\u306e\u7dad\u6301\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) APOE\u907a\u4f1d\u5b50\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u30ea\u30b9\u30af<\/strong><\/h3>\n\n\n\n<p>APOE\uff08\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30afE\uff09\u907a\u4f1d\u5b50\u306f\u3001\u8133\u306e\u8102\u8cea\u4ee3\u8b1d\u3084\u795e\u7d4c\u7d30\u80de\u306e\u5065\u5eb7\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: APOE4\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u6df1\u3044\u7761\u7720\u304c\u6e1b\u5c11\u3057\u3001\u7761\u7720\u4e2d\u306e\u8133\u306e\u8001\u5ec3\u7269\u9664\u53bb\u304c\u4f4e\u4e0b<\/li>\n\n\n\n<li>\u8a18\u61b6\u529b\u306e\u4f4e\u4e0b\u304c\u65e9\u307e\u308a\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u8a8d\u77e5\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u8cea\u306e\u9ad8\u3044\u7761\u7720\u3092\u78ba\u4fdd\u3059\u308b\u305f\u3081\u306b\u3001\u5c31\u5bdd\u524d\u306e\u30ea\u30e9\u30c3\u30af\u30b9\u7fd2\u6163\u3084\u6297\u9178\u5316\u4f5c\u7528\u306e\u3042\u308b\u98df\u54c1\uff08\u30d6\u30eb\u30fc\u30d9\u30ea\u30fc\u3001\u30d3\u30bf\u30df\u30f3E\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u304c\u91cd\u8981<\/strong>\u3067\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10788174\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) BDNF\u907a\u4f1d\u5b50\u3068\u7761\u7720\u4f9d\u5b58\u7684\u306a\u8a18\u61b6\u5f62\u6210<\/strong><\/h3>\n\n\n\n<p>BDNF\uff08\u8133\u7531\u6765\u795e\u7d4c\u6804\u990a\u56e0\u5b50\uff09\u907a\u4f1d\u5b50\u306f\u3001\u30b7\u30ca\u30d7\u30b9\u53ef\u5851\u6027\u3092\u8abf\u7bc0\u3057\u3001\u7761\u7720\u4e2d\u306e\u8a18\u61b6\u306e\u5b9a\u7740\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs6265\u306eMet\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u8a18\u61b6\u306e\u56fa\u5b9a\u304c\u5f31\u307e\u308a\u3001\u65b0\u3057\u3044\u60c5\u5831\u306e\u5b9a\u7740\u304c\u56f0\u96e3\u306b\u306a\u308b<\/li>\n\n\n\n<li>\u7761\u7720\u4e0d\u8db3\u306b\u3088\u308b\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u304c\u9855\u8457\u306b\u8868\u308c\u308b<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u9069\u5207\u306a\u7761\u7720\u6642\u9593\u3092\u78ba\u4fdd\u3057\u3001\u663c\u5bdd\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u8a18\u61b6\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b<\/strong>\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16106377\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>15. \u7761\u7720\u3068\u7cbe\u795e\u7684\u5065\u5eb7\uff1a\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/22782532_m-1024x683.jpg\" alt=\"\" class=\"wp-image-8878\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22782532_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22782532_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22782532_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22782532_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22782532_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u7761\u7720\u4e0d\u8db3\u306f\u30b9\u30c8\u30ec\u30b9\u3084\u4e0d\u5b89\u3092\u5897\u52a0\u3055\u305b\u308b\u8981\u56e0\u3068\u306a\u308a\u3001\u7cbe\u795e\u7684\u5065\u5eb7\u306b\u3082\u5927\u304d\u304f\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) 5-HTTLPR\u907a\u4f1d\u5b50\u3068\u30b9\u30c8\u30ec\u30b9\u8010\u6027<\/strong><\/h3>\n\n\n\n<p>5-HTTLPR\uff08\u30bb\u30ed\u30c8\u30cb\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u907a\u4f1d\u5b50\uff09\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u3078\u306e\u53cd\u5fdc\u3084\u6c17\u5206\u306e\u5b89\u5b9a\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: S\u578b\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30b9\u30c8\u30ec\u30b9\u306b\u654f\u611f\u3067\u3001\u7761\u7720\u4e0d\u8db3\u306b\u3088\u308b\u4e0d\u5b89\u611f\u304c\u5f37\u307e\u308b<\/li>\n\n\n\n<li>\u3046\u3064\u75c5\u3084\u4e0d\u5b89\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u304c\u5897\u52a0<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u5c31\u5bdd\u524d\u306b\u30ea\u30e9\u30c3\u30af\u30b9\u3059\u308b\u30eb\u30fc\u30c1\u30f3\u3092\u53d6\u308a\u5165\u308c\u3001\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u3092\u5b89\u5b9a\u3055\u305b\u308b\u3053\u3068\u304c\u91cd\u8981<\/strong>\u3067\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15241434\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) COMT\u907a\u4f1d\u5b50\u3068\u7761\u7720\u306b\u3088\u308b\u30b9\u30c8\u30ec\u30b9\u56de\u5fa9<\/strong><\/h3>\n\n\n\n<p>COMT\uff08\u30ab\u30c6\u30b3\u30fc\u30eb-O-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff09\u907a\u4f1d\u5b50\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308b\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u3084\u30c9\u30fc\u30d1\u30df\u30f3\u306e\u5206\u89e3\u3092\u8abf\u7bc0\u3057\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs4680\u306eMet\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u306e\u5206\u89e3\u304c\u9045\u304f\u3001\u8208\u596e\u72b6\u614b\u304c\u9577\u5f15\u304f<\/li>\n\n\n\n<li>\u7761\u7720\u306e\u8cea\u304c\u4f4e\u4e0b\u3057\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u4f4e\u4e0b<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u306e\u305f\u3081\u306b\u6df1\u547c\u5438\u6cd5\u3084\u7791\u60f3\u3092\u7fd2\u6163\u306b\u3059\u308b\u3053\u3068\u304c\u6709\u52b9<\/strong>\u3067\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12840240\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>16. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u672a\u6765\u306e\u7761\u7720\u30c6\u30af\u30ce\u30ed\u30b8\u30fc<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) \u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3068AI\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u7761\u7720\u30d7\u30e9\u30f3<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u57fa\u306b\u3057\u305f\u30aa\u30fc\u30c0\u30fc\u30e1\u30a4\u30c9\u306e\u7761\u7720\u6539\u5584\u30d7\u30ed\u30b0\u30e9\u30e0<\/strong><\/li>\n\n\n\n<li><strong>\u30a6\u30a7\u30a2\u30e9\u30d6\u30eb\u30c7\u30d0\u30a4\u30b9\u3068\u9023\u643a\u3057\u3001\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u7761\u7720\u72b6\u614b\u3092\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0<\/strong><\/li>\n\n\n\n<li><strong>AI\u306b\u3088\u308b\u30c7\u30fc\u30bf\u89e3\u6790\u3067\u3001\u500b\u4eba\u306e\u907a\u4f1d\u5b50\u578b\u306b\u6700\u9069\u306a\u7761\u7720\u6226\u7565\u3092\u63d0\u6848<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306b\u3088\u308b\u7761\u7720\u969c\u5bb3\u6cbb\u7642<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CRISPR\u6280\u8853\u3092\u5229\u7528\u3057\u305f\u6982\u65e5\u30ea\u30ba\u30e0\u7570\u5e38\u306e\u4fee\u6b63<\/strong><\/li>\n\n\n\n<li><strong>\u30ca\u30eb\u30b3\u30ec\u30d7\u30b7\u30fc\u3084\u4e0d\u7720\u75c7\u306e\u6839\u672c\u6cbb\u7642\u3092\u76ee\u6307\u3057\u305f\u907a\u4f1d\u5b50\u7642\u6cd5<\/strong><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6280\u8853\u304c\u9032\u5c55\u3059\u308b\u3053\u3068\u3067\u3001\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u7761\u7720\u7ba1\u7406\u304c\u53ef\u80fd\u306b\u306a\u308a\u3001\u3088\u308a\u500b\u5225\u5316\u3055\u308c\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u5b9f\u73fe\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>17. \u7761\u7720\u3068\u4ee3\u8b1d\u306e\u95a2\u4fc2\uff1a\u907a\u4f1d\u5b50\u306e\u5f71\u97ff<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/29959703_m-1024x585.jpg\" alt=\"\" class=\"wp-image-1291\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/29959703_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/29959703_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/29959703_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/29959703_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/29959703_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u7761\u7720\u306f\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306b\u3082\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u7761\u7720\u4e0d\u8db3\u306b\u3088\u308b\u80a5\u6e80\u3084\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) FTO\u907a\u4f1d\u5b50\u3068\u7761\u7720\u4e0d\u8db3\u306b\u3088\u308b\u98df\u6b32\u5897\u52a0<\/strong><\/h3>\n\n\n\n<p>FTO\uff08\u8102\u80aa\u8cea\u95a2\u9023\u907a\u4f1d\u5b50\uff09\u306f\u3001\u98df\u6b32\u3084\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u306b\u95a2\u4e0e\u3057\u3001\u7761\u7720\u4e0d\u8db3\u306b\u3088\u308b\u904e\u98df\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs9939609\u306eA\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7761\u7720\u4e0d\u8db3\u6642\u306b\u98df\u6b32\u3092\u5897\u9032\u3055\u305b\u308b\u30db\u30eb\u30e2\u30f3\uff08\u30b0\u30ec\u30ea\u30f3\uff09\u304c\u904e\u5270\u306b\u5206\u6ccc<\/li>\n\n\n\n<li>\u9ad8\u30ab\u30ed\u30ea\u30fc\u98df\u54c1\uff08\u7cd6\u8cea\u30fb\u8102\u8cea\uff09\u3092\u597d\u3080\u50be\u5411\u304c\u5f37\u307e\u308b<\/li>\n\n\n\n<li>\u80a5\u6e80\u30ea\u30b9\u30af\u304c1.2\uff5e1.6\u500d\u4e0a\u6607<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u898f\u5247\u7684\u306a\u7761\u7720\u3092\u78ba\u4fdd\u3059\u308b\u3053\u3068\u3067\u98df\u6b32\u30db\u30eb\u30e2\u30f3\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u6574\u3048\u3001\u904e\u98df\u3092\u9632\u3050\u3053\u3068\u304c\u91cd\u8981<\/strong>\u3067\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17658951\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) LEPR\u907a\u4f1d\u5b50\u3068\u30ec\u30d7\u30c1\u30f3\u611f\u53d7\u6027<\/strong><\/h3>\n\n\n\n<p>LEPR\uff08\u30ec\u30d7\u30c1\u30f3\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50\u306f\u3001\u6e80\u8179\u611f\u3092\u53f8\u308b\u30db\u30eb\u30e2\u30f3\u300c\u30ec\u30d7\u30c1\u30f3\u300d\u306e\u50cd\u304d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs1137101\u306eG\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30ec\u30d7\u30c1\u30f3\u306e\u611f\u53d7\u6027\u304c\u4f4e\u304f\u306a\u308a\u3001\u6e80\u8179\u611f\u3092\u611f\u3058\u306b\u304f\u3044<\/li>\n\n\n\n<li>\u7761\u7720\u4e0d\u8db3\u6642\u306b\u904e\u98df\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u5185\u81d3\u8102\u80aa\u306e\u84c4\u7a4d\u304c\u9032\u307f\u3084\u3059\u3044<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u98df\u4e8b\u306e\u969b\u306b\u98df\u7269\u7e4a\u7dad\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u591a\u304f\u6442\u53d6\u3057\u3001\u6e80\u8179\u611f\u3092\u9577\u304f\u7dad\u6301\u3059\u308b\u5de5\u592b\u304c\u63a8\u5968<\/strong>\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16467244\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>18. \u7761\u7720\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\uff1a\u907a\u4f1d\u7684\u30ea\u30b9\u30af<\/strong><\/h2>\n\n\n\n<p>\u7761\u7720\u306e\u8cea\u304c\u4f4e\u3044\u3068\u3001\u8840\u5727\u3084\u5fc3\u62cd\u6570\u306e\u8abf\u6574\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) NOS3\u907a\u4f1d\u5b50\u3068\u8840\u7ba1\u6a5f\u80fd<\/strong><\/h3>\n\n\n\n<p>NOS3\uff08\u5185\u76ae\u578b\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20\uff09\u907a\u4f1d\u5b50\u306f\u3001\u8840\u7ba1\u306e\u62e1\u5f35\u3092\u4fc3\u9032\u3057\u3001\u8840\u6d41\u3092\u6539\u5584\u3059\u308b\u50cd\u304d\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs1799983\u306eT\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u8840\u7ba1\u306e\u67d4\u8edf\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u52d5\u8108\u786c\u5316\u304c\u9032\u307f\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u7761\u7720\u4e0d\u8db3\u304c\u8840\u5727\u306e\u4e0a\u6607\u3092\u5f15\u304d\u8d77\u3053\u3057\u3084\u3059\u3044<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u9069\u5ea6\u306a\u6709\u9178\u7d20\u904b\u52d5\u3092\u884c\u3044\u3001\u8840\u7ba1\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u304c\u91cd\u8981<\/strong>\u3067\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15090699\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) ACE\u907a\u4f1d\u5b50\u3068\u9ad8\u8840\u5727\u30ea\u30b9\u30af<\/strong><\/h3>\n\n\n\n<p>ACE\uff08\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d20\uff09\u907a\u4f1d\u5b50\u306f\u3001\u8840\u5727\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3001\u7761\u7720\u4e0d\u8db3\u306b\u3088\u308b\u9ad8\u8840\u5727\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: ACE D\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4ea4\u611f\u795e\u7d4c\u304c\u6d3b\u6027\u5316\u3057\u3084\u3059\u304f\u3001\u8840\u5727\u304c\u4e0a\u6607\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u77ed\u6642\u9593\u7761\u7720\u304c\u7d9a\u304f\u3068\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u304c\u5897\u52a0<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u3092\u5fb9\u5e95\u3057\u3001\u5c31\u5bdd\u524d\u306b\u30ea\u30e9\u30c3\u30af\u30b9\u3059\u308b\u7fd2\u6163\u3092\u6301\u3064\u3053\u3068\u304c\u63a8\u5968<\/strong>\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15248123\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>19. \u7761\u7720\u3068\u8178\u5185\u74b0\u5883\uff1a\u907a\u4f1d\u5b50\u306e\u5f71\u97ff<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-1024x683.jpg\" alt=\"\" class=\"wp-image-8852\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8178\u5185\u74b0\u5883\u3068\u7761\u7720\u306f\u76f8\u4e92\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3001\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u7761\u7720\u306e\u8cea\u3092\u5de6\u53f3\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) FUT2\u907a\u4f1d\u5b50\u3068\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u591a\u69d8\u6027<\/strong><\/h3>\n\n\n\n<p>FUT2\uff08\u30d5\u30b3\u30b7\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc2\uff09\u907a\u4f1d\u5b50\u306f\u3001\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027\u306b\u95a2\u4e0e\u3057\u3001\u7761\u7720\u306e\u8cea\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs601338\u306eG\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u7761\u7720\u30db\u30eb\u30e2\u30f3\uff08\u30bb\u30ed\u30c8\u30cb\u30f3\u3001\u30e1\u30e9\u30c8\u30cb\u30f3\uff09\u306e\u5408\u6210\u304c\u4e0d\u5b89\u5b9a\u306b\u306a\u308b<\/li>\n\n\n\n<li>\u7761\u7720\u306e\u8cea\u304c\u60aa\u5316\u3057\u3084\u3059\u3044<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u767a\u9175\u98df\u54c1\u3084\u98df\u7269\u7e4a\u7dad\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3057\u3001\u8178\u5185\u74b0\u5883\u3092\u6574\u3048\u308b\u3053\u3068\u304c\u63a8\u5968<\/strong>\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21979192\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(2) TLR4\u907a\u4f1d\u5b50\u3068\u8178\u5185\u708e\u75c7<\/strong><\/h3>\n\n\n\n<p>TLR4\uff08\u30c8\u30fc\u30eb\u69d8\u53d7\u5bb9\u4f534\uff09\u907a\u4f1d\u5b50\u306f\u3001\u8178\u5185\u306e\u514d\u75ab\u5fdc\u7b54\u3092\u8abf\u6574\u3057\u3001\u7761\u7720\u3068\u8178\u5185\u74b0\u5883\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs4986790\u306eA\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u8178\u5185\u708e\u75c7\u304c\u4fc3\u9032\u3055\u308c\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u7761\u7720\u6642\u306e\u56de\u5fa9\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u75b2\u52b4\u611f\u304c\u629c\u3051\u306b\u304f\u3044<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u6297\u708e\u75c7\u4f5c\u7528\u306e\u3042\u308b\u98df\u54c1\uff08\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3001\u7dd1\u8336\u3001\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff09\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u8178\u5185\u74b0\u5883\u3092\u6574\u3048\u308b\u3053\u3068\u304c\u6709\u52b9<\/strong>\u3067\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18604270\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>20. \u907a\u4f1d\u5b50\u3068\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306e\u5f71\u97ff\uff1a\u7761\u7720\u306e\u6700\u9069\u5316<\/strong><\/h2>\n\n\n\n<p>\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306f\u7761\u7720\u306e\u8cea\u306b\u5927\u304d\u304f\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u304c\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u8abf\u7bc0\u6a5f\u80fd\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>(1) NR3C1\u907a\u4f1d\u5b50\u3068\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3<\/strong><\/h3>\n\n\n\n<p>NR3C1\uff08\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50\u306f\u3001\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\uff08\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\uff09\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08\u4f8b: rs6198\u306eG\u30a2\u30ec\u30eb\uff09\u3092\u6301\u3064\u5834\u5408<\/strong>\n<ul 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class=\"wp-block-heading\"><strong>\u307e\u3068\u3081<\/strong><\/h2>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306f\u7761\u7720\u306e\u8cea\u3084\u30d1\u30bf\u30fc\u30f3\u3001\u3055\u3089\u306b\u306f\u4ee3\u8b1d\u3084\u514d\u75ab\u6a5f\u80fd\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u91cd\u8981\u306a\u8981\u7d20\u3067\u3059\u3002<strong>CLOCK\u3001PER\u3001BMAL1<\/strong>\u306a\u3069\u306e\u6982\u65e5\u30ea\u30ba\u30e0\u95a2\u9023\u907a\u4f1d\u5b50\u304c\u7761\u7720\u6642\u9593\u3084\u30bf\u30a4\u30df\u30f3\u30b0\u3092\u6c7a\u5b9a\u3057\u3001<strong>FTO\u3084LEPR<\/strong>\u3068\u3044\u3063\u305f\u4ee3\u8b1d\u95a2\u9023\u907a\u4f1d\u5b50\u304c\u7761\u7720\u4e0d\u8db3\u6642\u306e\u98df\u6b32\u5897\u52a0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001<strong>IL6\u3084TNF<\/strong>\u306a\u3069\u306e\u708e\u75c7\u95a2\u9023\u907a\u4f1d\u5b50\u306f\u3001\u7761\u7720\u3068\u514d\u75ab\u6a5f\u80fd\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3001\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u7761\u7720\u7ba1\u7406\u304c\u4e00\u822c\u5316\u3057\u3001\u4e00\u4eba\u3072\u3068\u308a\u306b\u6700\u9069\u306a\u7761\u7720\u7fd2\u6163\u306e\u78ba\u7acb\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1. 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[&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":13838,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6],"tags":[52,41,59,36,49,34,45,55],"class_list":["post-8870","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-basicknowledge","tag-dna-test","tag-personalized-medicine","tag-59","tag-gene-testing","tag-gene-analysis","tag-genetic-identification","tag-genetics","tag-genetic-diseases"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/8870","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=8870"}],"version-history":[{"count":3,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/8870\/revisions"}],"predecessor-version":[{"id":14034,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/8870\/revisions\/14034"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/13838"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=8870"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=8870"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=8870"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}