{"id":9376,"date":"2025-03-10T08:09:39","date_gmt":"2025-03-10T08:09:39","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=9376"},"modified":"2025-03-10T08:09:40","modified_gmt":"2025-03-10T08:09:40","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e5%af%bf%e5%91%bd%ef%bc%9a%e9%81%ba%e4%bc%9d%e7%9a%84%e8%a6%81%e5%9b%a0%e3%81%8c%e7%a4%ba%e3%81%99%e9%95%b7%e5%af%bf%e3%81%ae%e7%a7%98%e8%a8%a3","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e5%af%bf%e5%91%bd%ef%bc%9a%e9%81%ba%e4%bc%9d%e7%9a%84%e8%a6%81%e5%9b%a0%e3%81%8c%e7%a4%ba%e3%81%99%e9%95%b7%e5%af%bf%e3%81%ae%e7%a7%98%e8%a8%a3\/","title":{"rendered":"\u907a\u4f1d\u5b50\u3068\u5bff\u547d\uff1a\u907a\u4f1d\u7684\u8981\u56e0\u304c\u793a\u3059\u9577\u5bff\u306e\u79d8\u8a23"},"content":{"rendered":"\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u5bff\u547d\u306e\u95a2\u4fc2\u3068\u306f\uff1f<\/strong><\/h2>\n\n\n\n<p>\u4eba\u9593\u306e\u5bff\u547d\u306f\u3001\u907a\u4f1d\u3068\u74b0\u5883\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u6c7a\u307e\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u9577\u5bff\u3092\u5b9f\u73fe\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u5065\u5eb7\u7684\u306a\u751f\u6d3b\u7fd2\u6163\u304c\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u306f\u5e83\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u8fd1\u5e74\u306e\u7814\u7a76\u306b\u3088\u3063\u3066\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u5bff\u547d\u306e\u9577\u3055\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002<br>\u3053\u306e\u5206\u91ce\u306e\u7814\u7a76\u306f\u3001\u5358\u306a\u308b\u7406\u8ad6\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u5c06\u6765\u7684\u306a\u8001\u5316\u9632\u6b62\u3084\u9577\u5bff\u793e\u4f1a\u306e\u5b9f\u73fe\u306b\u5411\u3051\u305f\u91cd\u8981\u306a\u77e5\u898b\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u5bff\u547d\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u3084\u305d\u306e\u50cd\u304d\u3001\u3055\u3089\u306b\u306f\u907a\u4f1d\u5b50\u7814\u7a76\u304c\u3082\u305f\u3089\u3059\u672a\u6765\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u9577\u5bff\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u3068\u306f\uff1f<\/strong><\/h2>\n\n\n\n<p>\u8fd1\u5e74\u3001\u591a\u304f\u306e\u7814\u7a76\u8005\u304c\u9577\u5bff\u306b\u5bc4\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u3092\u7279\u5b9a\u3057\u3088\u3046\u3068\u8a66\u307f\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4e2d\u3067\u3082\u7279\u306b\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u306e\u304c\u3001FOXO3\u3001SIRT1\u3001APOE\u3001KLOTHO\u306a\u3069\u306e\u907a\u4f1d\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. FOXO3\u907a\u4f1d\u5b50\uff1a\u9577\u5bff\u306e\u6c7a\u5b9a\u56e0\u5b50<\/strong><\/h3>\n\n\n\n<p>FOXO3\uff08Forkhead box O3\uff09\u907a\u4f1d\u5b50\u306f\u3001\u9577\u5bff\u3068\u5bc6\u63a5\u306b\u95a2\u9023\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306f\u3001\u7d30\u80de\u306e\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3084\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u9632\u5fa1\u3001DNA\u4fee\u5fa9\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u52a0\u9f62\u306b\u3088\u308b\u30c0\u30e1\u30fc\u30b8\u3092\u6291\u5236\u3059\u308b\u50cd\u304d\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<br>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u65e5\u672c\u306e\u6c96\u7e04\u306e100\u6b73\u4ee5\u4e0a\u306e\u9577\u5bff\u8005\uff08\u30bb\u30f3\u30c6\u30ca\u30ea\u30a2\u30f3\uff09\u306b\u306f\u3001FOXO3\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u304c\u591a\u3044\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/\">\u53c2\u8003: National Institutes of Health (NIH)<\/a>)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. SIRT1\u907a\u4f1d\u5b50\uff1a\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u9175\u7d20\u3092\u8abf\u7bc0<\/strong><\/h3>\n\n\n\n<p>SIRT1\uff08\u30b5\u30fc\u30c1\u30e5\u30a4\u30f31\uff09\u907a\u4f1d\u5b50\u306f\u3001\u9577\u5bff\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u3068\u3057\u3066\u5e83\u304f\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002SIRT1\u306f\u3001NAD+\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30a2\u30c7\u30cb\u30f3\u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff09\u4f9d\u5b58\u6027\u306e\u9175\u7d20\u3067\u3042\u308a\u3001\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3084\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3001\u708e\u75c7\u306e\u6291\u5236\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002<br>SIRT1\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u8001\u5316\u30d7\u30ed\u30bb\u30b9\u3092\u9045\u3089\u305b\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u304a\u308a\u3001\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\uff08\u8d64\u30ef\u30a4\u30f3\u306b\u542b\u307e\u308c\u308b\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff09\u306a\u3069\u306e\u5316\u5408\u7269\u304cSIRT1\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002(\u53c2\u8003: Cell Metabolism Journal)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. APOE\u907a\u4f1d\u5b50\uff1a\u8a8d\u77e5\u75c7\u3068\u9577\u5bff\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>APOE\uff08\u30a2\u30dd\u30ea\u30dd\u30d7\u30ed\u30c6\u30a4\u30f3E\uff09\u907a\u4f1d\u5b50\u306f\u3001\u4e3b\u306b\u8102\u8cea\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3057\u307e\u3059\u304c\u3001\u305d\u306e\u5909\u7570\u578b\uff08\u7279\u306bAPOE \u03b54\u30a2\u30ec\u30eb\uff09\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001APOE \u03b52\u30a2\u30ec\u30eb\u306f\u3001\u8a8d\u77e5\u75c7\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3057\u3001\u9577\u5bff\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br>\u3053\u306e\u3053\u3068\u304b\u3089\u3001APOE\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u3005\u306f\u3001\u8133\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3057\u3084\u3059\u304f\u3001\u7d50\u679c\u7684\u306b\u9577\u5bff\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4. KLOTHO\u907a\u4f1d\u5b50\uff1a\u6297\u8001\u5316\u306e\u9375\u3068\u306a\u308b\u30bf\u30f3\u30d1\u30af\u8cea<\/strong><\/h3>\n\n\n\n<p>KLOTHO\u907a\u4f1d\u5b50\u306f\u3001\u6297\u8001\u5316\u30bf\u30f3\u30d1\u30af\u8cea\u300c\u30af\u30ed\u30c8\u30fc\u300d\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u5bff\u547d\u306e\u5ef6\u9577\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u30af\u30ed\u30c8\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3084\u7d30\u80de\u8001\u5316\u3092\u6291\u5236\u3059\u308b\u50cd\u304d\u3092\u6301\u3061\u3001\u7279\u306b\u814e\u6a5f\u80fd\u3084\u8a8d\u77e5\u6a5f\u80fd\u306e\u7dad\u6301\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002<br>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001KLOTHO\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u3053\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u304c\u5897\u3048\u308b\u3068\u3001\u5065\u5eb7\u5bff\u547d\u304c\u5ef6\u3073\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.nature.com\/\">\u53c2\u8003: Nature Aging<\/a>)<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u3068\u74b0\u5883\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/4440226_m-1024x683.jpg\" alt=\"\u30de\u30c3\u30c8\u4e0a\u3067\u904a\u3076\u5e7c\u5150\u305f\u3061\" class=\"wp-image-9077\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4440226_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4440226_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4440226_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4440226_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4440226_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u9577\u5bff\u3092\u6c7a\u5b9a\u3059\u308b\u8981\u56e0\u306f\u3001\u907a\u4f1d\u3060\u3051\u3067\u306a\u304f\u74b0\u5883\u3068\u3082\u6df1\u304f\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u7684\u306b\u9577\u5bff\u306b\u306a\u308a\u3084\u3059\u3044\u4f53\u8cea\u3092\u6301\u3063\u3066\u3044\u3066\u3082\u3001\u4e0d\u5065\u5eb7\u306a\u751f\u6d3b\u7fd2\u6163\u3092\u7d9a\u3051\u3066\u3044\u308c\u3070\u3001\u5bff\u547d\u3092\u77ed\u304f\u3057\u3066\u3057\u307e\u3046\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u3068\u74b0\u5883\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u9577\u5bff\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306e\u4f8b\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u98df\u751f\u6d3b\u306e\u5f71\u97ff<\/strong>: \u6c96\u7e04\u306e\u4f1d\u7d71\u7684\u306a\u98df\u4e8b\uff08\u4f4e\u30ab\u30ed\u30ea\u30fc\u30fb\u9ad8\u6804\u990a\u306e\u98df\u4e8b\uff09\u306f\u3001\u9577\u5bff\u907a\u4f1d\u5b50FOXO3\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u904b\u52d5\u7fd2\u6163<\/strong>: \u9069\u5ea6\u306a\u904b\u52d5\u306fSIRT1\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u3001\u7d30\u80de\u306e\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406<\/strong>: \u9577\u5bff\u8005\u306b\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u9ad8\u3044\u50be\u5411\u304c\u3042\u308a\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u9069\u5207\u306b\u5bfe\u51e6\u3059\u308b\u3053\u3068\u304c\u5065\u5eb7\u5bff\u547d\u3092\u5ef6\u3070\u3059\u8981\u56e0\u306e\u4e00\u3064\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u7684\u8981\u56e0\u304c\u76f8\u4e92\u306b\u4f5c\u7528\u3057\u306a\u304c\u3089\u3001\u500b\u3005\u306e\u5bff\u547d\u3092\u6c7a\u5b9a\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u7814\u7a76\u304c\u3082\u305f\u3089\u3059\u672a\u6765\u306e\u5c55\u671b<\/strong><\/h2>\n\n\n\n<p>\u5bff\u547d\u306b\u95a2\u3059\u308b\u907a\u4f1d\u5b50\u7814\u7a76\u304c\u9032\u3080\u3053\u3068\u3067\u3001\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u3001\u907a\u4f1d\u5b50\u6cbb\u7642\u3084\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\uff08\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u8abf\u7bc0\uff09\u3092\u6d3b\u7528\u3057\u305f\u65b0\u3057\u3044\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u6280\u8853\u304c\u7814\u7a76\u3055\u308c\u3066\u304a\u308a\u3001\u4eca\u5f8c\u3055\u3089\u306b\u9032\u5c55\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u907a\u4f1d\u5b50\u7de8\u96c6\u306b\u3088\u308b\u8001\u5316\u9632\u6b62<\/strong><\/h3>\n\n\n\n<p>CRISPR-Cas9\u306a\u3069\u306e\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u9577\u5bff\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3057\u3001\u8001\u5316\u30d7\u30ed\u30bb\u30b9\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u7279\u306b\u3001FOXO3\u3084SIRT1\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u907a\u4f1d\u5b50\u6539\u5909\u304c\u691c\u8a0e\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u5e79\u7d30\u80de\u7642\u6cd5\u3068\u518d\u751f\u533b\u7642<\/strong><\/h3>\n\n\n\n<p>iPS\u7d30\u80de\uff08\u4eba\u5de5\u591a\u80fd\u6027\u5e79\u7d30\u80de\uff09\u6280\u8853\u3092\u6d3b\u7528\u3057\u3001\u8001\u5316\u3057\u305f\u7d30\u80de\u3092\u82e5\u8fd4\u3089\u305b\u308b\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u52a0\u9f62\u306b\u3088\u308b\u7d44\u7e54\u306e\u52a3\u5316\u3092\u6291\u3048\u3001\u5065\u5eb7\u5bff\u547d\u3092\u5ef6\u3070\u3059\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \u907a\u4f1d\u5b50\u89e3\u6790\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u533b\u7642<\/strong><\/h3>\n\n\n\n<p>\u5c06\u6765\u7684\u306b\u306f\u3001\u500b\u3005\u306e\u907a\u4f1d\u5b50\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306b\u57fa\u3065\u3044\u3066\u6700\u9069\u306a\u5065\u5eb7\u7ba1\u7406\u6cd5\u3092\u63d0\u6848\u3059\u308b\u300c\u500b\u5225\u5316\u533b\u7642\u300d\u304c\u4e00\u822c\u5316\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u907a\u4f1d\u5b50\u89e3\u6790\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u305d\u306e\u4eba\u306b\u5408\u3063\u305f\u98df\u4e8b\u3001\u904b\u52d5\u3001\u751f\u6d3b\u7fd2\u6163\u3092\u79d1\u5b66\u7684\u306b\u63d0\u6848\u3057\u3001\u5bff\u547d\u3092\u5ef6\u3070\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u5909\u7570\u3068\u5bff\u547d\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"675\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/23265903_m-1024x675.jpg\" alt=\"\" class=\"wp-image-9180\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/23265903_m-1024x675.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/23265903_m-300x198.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/23265903_m-768x506.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/23265903_m-1536x1012.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/23265903_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306f\u5bff\u547d\u3092\u6c7a\u5b9a\u3059\u308b\u91cd\u8981\u306a\u8981\u7d20\u3067\u3059\u304c\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u5bff\u547d\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3082\u5927\u304d\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3044\u304f\u3064\u304b\u306e\u7814\u7a76\u3067\u306f\u3001\u907a\u4f1d\u5b50\u306e\u7a81\u7136\u5909\u7570\u304c\u9577\u5bff\u3092\u4fc3\u9032\u3059\u308b\u5834\u5408\u3068\u3001\u9006\u306b\u5bff\u547d\u3092\u77ed\u7e2e\u3059\u308b\u5834\u5408\u306e\u4e21\u65b9\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. mTOR\u7d4c\u8def\u306e\u5909\u7570\u3068\u5bff\u547d\u306e\u5ef6\u9577<\/strong><\/h4>\n\n\n\n<p>mTOR\uff08\u30e1\u30ab\u30cb\u30b9\u30c6\u30a3\u30c3\u30af\u30bf\u30fc\u30b2\u30c3\u30c8\u30aa\u30d6\u30e9\u30d1\u30de\u30a4\u30b7\u30f3\uff09\u7d4c\u8def\u306f\u3001\u7d30\u80de\u6210\u9577\u3084\u4ee3\u8b1d\u3092\u8abf\u7bc0\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3067\u3059\u3002mTOR\u306e\u6d3b\u6027\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u7d30\u80de\u306e\u81ea\u5df1\u4fee\u5fa9\u6a5f\u80fd\uff08\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\uff09\u304c\u6d3b\u767a\u306b\u306a\u308a\u3001\u8001\u5316\u306e\u9032\u884c\u304c\u9045\u304f\u306a\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30e9\u30d1\u30de\u30a4\u30b7\u30f3\u3068\u3044\u3046\u85ac\u5264\u306fmTOR\u306e\u6d3b\u6027\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u30de\u30a6\u30b9\u3084\u7dda\u866b\u3092\u7528\u3044\u305f\u5b9f\u9a13\u3067\u306f\u5bff\u547d\u3092\u5ef6\u3070\u3059\u52b9\u679c\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u3001\u3053\u306emTOR\u7d4c\u8def\u3092\u6a19\u7684\u3068\u3057\u305f\u6297\u8001\u5316\u6cbb\u7642\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. DNA\u4fee\u5fa9\u907a\u4f1d\u5b50\u306e\u7a81\u7136\u5909\u7570<\/strong><\/h4>\n\n\n\n<p>DNA\u306f\u65e5\u3005\u640d\u50b7\u3092\u53d7\u3051\u3066\u304a\u308a\u3001\u305d\u308c\u3092\u4fee\u5fa9\u3059\u308b\u6a5f\u69cb\u304c\u5b58\u5728\u3057\u307e\u3059\u3002\u7279\u306b\u3001WRN\u907a\u4f1d\u5b50\u3084TP53\u907a\u4f1d\u5b50\u306f\u3001DNA\u306e\u640d\u50b7\u4fee\u5fa9\u3084\u7d30\u80de\u306e\u751f\u5b58\u306b\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>WRN\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong>: \u3053\u306e\u907a\u4f1d\u5b50\u306e\u7a81\u7136\u5909\u7570\u304c\u30a6\u30a7\u30eb\u30ca\u30fc\u75c7\u5019\u7fa4\uff08\u65e9\u8001\u75c7\uff09\u306e\u539f\u56e0\u3068\u306a\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30a6\u30a7\u30eb\u30ca\u30fc\u75c7\u5019\u7fa4\u306e\u60a3\u8005\u306f\u82e5\u5e74\u671f\u304b\u3089\u8001\u5316\u306e\u5146\u5019\u3092\u793a\u3057\u3001\u901a\u5e38\u306e\u4eba\u3088\u308a\u3082\u5bff\u547d\u304c\u77ed\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>TP53\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong>: TP53\u306f\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u6a5f\u80fd\u304c\u6b63\u5e38\u306b\u50cd\u304b\u306a\u3044\u3068\u7d30\u80de\u306e\u7570\u5e38\u5897\u6b96\u304c\u8d77\u3053\u308a\u3084\u3059\u304f\u306a\u308a\u3001\u304c\u3093\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001TP53\u306e\u6d3b\u6027\u304c\u904e\u5270\u306b\u306a\u308b\u3068\u7d30\u80de\u306e\u5bff\u547d\u304c\u77ed\u304f\u306a\u308b\u3053\u3068\u3082\u3042\u308b\u305f\u3081\u3001\u30d0\u30e9\u30f3\u30b9\u304c\u91cd\u8981\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3. \u30c6\u30ed\u30e1\u30a2\u306e\u9577\u3055\u3068\u5bff\u547d<\/strong><\/h4>\n\n\n\n<p>\u30c6\u30ed\u30e1\u30a2\u306f\u67d3\u8272\u4f53\u306e\u672b\u7aef\u90e8\u5206\u306b\u3042\u308bDNA\u914d\u5217\u3067\u3001\u7d30\u80de\u5206\u88c2\u306e\u305f\u3073\u306b\u77ed\u304f\u306a\u3063\u3066\u3044\u304d\u307e\u3059\u3002\u30c6\u30ed\u30e1\u30a2\u304c\u4e00\u5b9a\u306e\u9577\u3055\u4ee5\u4e0b\u306b\u306a\u308b\u3068\u3001\u7d30\u80de\u306f\u5206\u88c2\u3092\u505c\u6b62\u3057\u3001\u8001\u5316\u304c\u9032\u884c\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30c6\u30ed\u30e1\u30e9\u30fc\u30bc\u3068\u3044\u3046\u9175\u7d20\u306f\u3001\u30c6\u30ed\u30e1\u30a2\u306e\u77ed\u7e2e\u3092\u9632\u3050\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u306b\u3088\u308a\u30c6\u30ed\u30e1\u30e9\u30fc\u30bc\u6d3b\u6027\u304c\u9ad8\u307e\u308b\u3068\u3001\u30c6\u30ed\u30e1\u30a2\u306e\u77ed\u7e2e\u304c\u9045\u304f\u306a\u308a\u3001\u7d50\u679c\u3068\u3057\u3066\u5bff\u547d\u304c\u5ef6\u3073\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u9006\u306b\u3001\u30c6\u30ed\u30e1\u30e9\u30fc\u30bc\u306e\u50cd\u304d\u304c\u5f31\u307e\u308b\u3068\u3001\u7d30\u80de\u306e\u8001\u5316\u304c\u52a0\u901f\u3057\u3001\u5bff\u547d\u304c\u77ed\u304f\u306a\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5909\u5316\u3068\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/29217899_m-1024x683.jpg\" alt=\"\" class=\"wp-image-9254\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29217899_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29217899_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29217899_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29217899_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29217899_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u5bff\u547d\u306b\u95a2\u308f\u308b\u3082\u3046\u4e00\u3064\u306e\u91cd\u8981\u306a\u8981\u7d20\u304c\u300c\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u300d\u3067\u3059\u3002\u3053\u308c\u306f\u3001DNA\u306e\u5869\u57fa\u914d\u5217\u81ea\u4f53\u3092\u5909\u3048\u305a\u306b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u4ed5\u7d44\u307f\u3092\u6307\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. DNA\u30e1\u30c1\u30eb\u5316\u3068\u8001\u5316<\/strong><\/h4>\n\n\n\n<p>DNA\u30e1\u30c1\u30eb\u5316\u306f\u3001\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u90e8\u4f4d\u306b\u30e1\u30c1\u30eb\u57fa\u304c\u4ed8\u52a0\u3055\u308c\u308b\u3053\u3068\u3067\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u6a5f\u69cb\u3067\u3059\u3002\u52a0\u9f62\u3068\u3068\u3082\u306bDNA\u30e1\u30c1\u30eb\u5316\u306e\u30d1\u30bf\u30fc\u30f3\u304c\u5909\u5316\u3057\u3001\u8001\u5316\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8fd1\u5e74\u3001DNA\u30e1\u30c1\u30eb\u5316\u306e\u72b6\u614b\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u3067\u300c\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u6642\u8a08\u300d\u3092\u4f5c\u6210\u3057\u3001\u751f\u7269\u306e\u5b9f\u969b\u306e\u751f\u7269\u5b66\u7684\u5e74\u9f62\u3092\u63a8\u5b9a\u3059\u308b\u624b\u6cd5\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u3053\u306e\u6280\u8853\u3092\u6d3b\u7528\u3059\u308c\u3070\u3001\u52a0\u9f62\u3092\u9045\u3089\u305b\u308b\u4ecb\u5165\u6cd5\u306e\u52b9\u679c\u3092\u79d1\u5b66\u7684\u306b\u8a55\u4fa1\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u3068\u9577\u5bff<\/strong><\/h4>\n\n\n\n<p>\u30d2\u30b9\u30c8\u30f3\u306fDNA\u3092\u5dfb\u304d\u3064\u3051\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u3053\u308c\u306b\u30a2\u30bb\u30c1\u30eb\u5316\u3084\u30e1\u30c1\u30eb\u5316\u306a\u3069\u306e\u4fee\u98fe\u304c\u52a0\u308f\u308b\u3053\u3068\u3067\u907a\u4f1d\u5b50\u767a\u73fe\u304c\u8abf\u7bc0\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30d2\u30b9\u30c8\u30f3\u306e\u30a2\u30bb\u30c1\u30eb\u5316\u304c\u5897\u52a0\u3059\u308b\u3068\u3001\u907a\u4f1d\u5b50\u304c\u6d3b\u6027\u5316\u3055\u308c\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u7d30\u80de\u306e\u4fee\u5fa9\u80fd\u529b\u304c\u5411\u4e0a\u3057\u3001\u5bff\u547d\u304c\u5ef6\u3073\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u4e00\u65b9\u3001\u30d2\u30b9\u30c8\u30f3\u306e\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u304c\u9032\u3080\u3068\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u304c\u6291\u5236\u3055\u308c\u3001\u8001\u5316\u304c\u52a0\u901f\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u9577\u5bff\u907a\u4f1d\u5b50\u306e\u7814\u7a76\u3068\u30d2\u30c8\u3078\u306e\u5fdc\u7528<\/strong><\/h3>\n\n\n\n<p>\u9577\u5bff\u907a\u4f1d\u5b50\u306e\u7814\u7a76\u306f\u3001\u4e3b\u306b\u52d5\u7269\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u30d2\u30c8\u306b\u304a\u3044\u3066\u3082\u5bff\u547d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u30d2\u30c8\u306e\u9577\u5bff\u8005\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u89e3\u6790<\/strong><\/h4>\n\n\n\n<p>100\u6b73\u3092\u8d85\u3048\u308b\u9577\u5bff\u8005\uff08\u30b9\u30fc\u30d1\u30fc\u30bb\u30f3\u30c6\u30ca\u30ea\u30a2\u30f3\uff09\u3092\u5bfe\u8c61\u3068\u3057\u305f\u907a\u4f1d\u5b50\u89e3\u6790\u306b\u3088\u308b\u3068\u3001FOXO3\u3001SIRT1\u3001KLOTHO\u306a\u3069\u306e\u907a\u4f1d\u5b50\u306b\u7279\u5b9a\u306e\u5909\u7570\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306f\u3001\u7d30\u80de\u306e\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3084\u4ee3\u8b1d\u5236\u5fa1\u306b\u95a2\u308f\u308b\u305f\u3081\u3001\u8001\u5316\u306e\u9032\u884c\u3092\u6291\u5236\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u9577\u5bff\u8005\u306e\u907a\u4f1d\u5b50\u306b\u306f\u708e\u75c7\u3092\u6291\u3048\u308b\u50cd\u304d\u304c\u5f37\u3044\u3082\u306e\u304c\u591a\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u52a0\u9f62\u3068\u3068\u3082\u306b\u6162\u6027\u708e\u75c7\uff08\u30a4\u30f3\u30d5\u30e9\u30e1\u30a4\u30b8\u30f3\u30b0\uff09\u304c\u9032\u884c\u3059\u308b\u3068\u3001\u52d5\u8108\u786c\u5316\u3084\u8a8d\u77e5\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002\u9577\u5bff\u8005\u306f\u3053\u306e\u708e\u75c7\u3092\u6291\u5236\u3059\u308b\u907a\u4f1d\u7684\u8981\u56e0\u3092\u6301\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u9577\u5bff\u907a\u4f1d\u5b50\u3092\u6d3b\u7528\u3057\u305f\u533b\u7642\u6280\u8853\u306e\u767a\u5c55<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7814\u7a76\u304c\u9032\u3080\u3053\u3068\u3067\u3001\u5bff\u547d\u3092\u5ef6\u3070\u3059\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>**\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\uff08CRISPR-Cas9\uff09**\u3092\u7528\u3044\u3066\u3001\u9577\u5bff\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u3092\u6d3b\u6027\u5316\u307e\u305f\u306f\u4e0d\u6d3b\u6027\u5316\u3059\u308b\u8a66\u307f\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001FOXO3\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u9ad8\u3081\u308b\u3053\u3068\u3067\u3001\u52a0\u9f62\u306b\u3088\u308b\u75be\u60a3\u3092\u4e88\u9632\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u85ac\u5264<\/strong>\u306e\u958b\u767a\u3082\u9032\u3093\u3067\u304a\u308a\u3001\u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u3084DNA\u30e1\u30c1\u30eb\u5316\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3067\u3001\u8001\u5316\u95a2\u9023\u75be\u60a3\u306e\u767a\u75c7\u3092\u6291\u3048\u308b\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u304c\u6a21\u7d22\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>**\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30fb\u30e1\u30c7\u30a3\u30b7\u30f3\uff08\u500b\u5225\u5316\u533b\u7642\uff09**\u3067\u306f\u3001\u500b\u3005\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u89e3\u6790\u3057\u3001\u305d\u308c\u306b\u57fa\u3065\u3044\u3066\u6700\u9069\u306a\u5065\u5eb7\u7ba1\u7406\u30d7\u30e9\u30f3\u3092\u63d0\u4f9b\u3059\u308b\u6280\u8853\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u4eca\u5f8c\u306e\u7814\u7a76\u8ab2\u984c\u3068\u5c55\u671b<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/29757183_m-1024x683.jpg\" alt=\"\u30a6\u30a3\u30eb\u30b9\u3092\u78ba\u8a8d\u3059\u308b\u4eba\u306e\u624b\u5143\" class=\"wp-image-9144\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29757183_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29757183_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29757183_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29757183_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29757183_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u73fe\u5728\u306e\u3068\u3053\u308d\u3001\u907a\u4f1d\u5b50\u304c\u5bff\u547d\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306f\u660e\u3089\u304b\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u304c\u3001\u307e\u3060\u591a\u304f\u306e\u8b0e\u304c\u6b8b\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u9577\u5bff\u907a\u4f1d\u5b50\u304c\u3069\u306e\u7a0b\u5ea6\u74b0\u5883\u8981\u56e0\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u306e\u304b<\/li>\n\n\n\n<li>\u8001\u5316\u3092\u5b8c\u5168\u306b\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306a\u306e\u304b<\/li>\n\n\n\n<li>\u907a\u4f1d\u5b50\u64cd\u4f5c\u306b\u3088\u3063\u3066\u5bff\u547d\u3092\u5ef6\u3070\u3059\u3053\u3068\u306e\u502b\u7406\u7684\u8ab2\u984c<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u7591\u554f\u306b\u7b54\u3048\u308b\u305f\u3081\u306b\u3001\u4eca\u5f8c\u306e\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u5c55\u304c\u91cd\u8981\u3068\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u95a2\u4fc2\uff1a\u9577\u5bff\u3092\u652f\u3048\u308b\u9632\u5fa1\u6a5f\u69cb<\/strong><\/h3>\n\n\n\n<p>\u4eba\u9593\u306e\u5bff\u547d\u306f\u3001\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u50cd\u304d\u3068\u3082\u5bc6\u63a5\u306b\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u3002\u52a0\u9f62\u3068\u3068\u3082\u306b\u514d\u75ab\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u611f\u67d3\u75c7\u3084\u6162\u6027\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u304c\u3001\u907a\u4f1d\u5b50\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u514d\u75ab\u6a5f\u80fd\u306e\u7dad\u6301\u80fd\u529b\u306b\u500b\u4eba\u5dee\u304c\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. HLA\u907a\u4f1d\u5b50\u3068\u9577\u5bff<\/strong><\/h4>\n\n\n\n<p>HLA\uff08\u30d2\u30c8\u767d\u8840\u7403\u6297\u539f\uff09\u907a\u4f1d\u5b50\u306f\u3001\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u304c\u7570\u7269\u3092\u8a8d\u8b58\u3059\u308b\u305f\u3081\u306e\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u5b9a\u306eHLA\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\uff08\u907a\u4f1d\u7684\u306a\u30bb\u30c3\u30c8\uff09\u304c\u9577\u5bff\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001100\u6b73\u4ee5\u4e0a\u306e\u9577\u5bff\u8005\u306b\u7279\u5b9a\u306eHLA\u30d0\u30ea\u30a2\u30f3\u30c8\u304c\u591a\u304f\u898b\u3089\u308c\u308b\u3068\u3044\u3046\u7814\u7a76\u7d50\u679c\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>HLA\u907a\u4f1d\u5b50\u306e\u591a\u69d8\u6027\u304c\u9ad8\u3044\u500b\u4f53\u306f\u3001\u3088\u308a\u591a\u304f\u306e\u75c5\u539f\u4f53\u306b\u5bfe\u3057\u3066\u5f37\u3044\u514d\u75ab\u5fdc\u7b54\u3092\u793a\u3059\u305f\u3081\u3001\u611f\u67d3\u75c7\u3092\u56de\u907f\u3057\u3084\u3059\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u9006\u306b\u3001HLA\u306e\u591a\u69d8\u6027\u304c\u4f4e\u3044\u5834\u5408\u3001\u7279\u5b9a\u306e\u75c5\u539f\u4f53\u306b\u5bfe\u3057\u3066\u8106\u5f31\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\u95a2\u9023\u907a\u4f1d\u5b50\u3068\u6297\u708e\u75c7\u4f5c\u7528<\/strong><\/h4>\n\n\n\n<p>\u708e\u75c7\u306f\u8001\u5316\u306e\u5927\u304d\u306a\u8981\u56e0\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u300c\u6162\u6027\u708e\u75c7\uff08\u30a4\u30f3\u30d5\u30e9\u30e1\u30a4\u30b8\u30f3\u30b0\uff09\u300d\u306f\u52d5\u8108\u786c\u5316\u3084\u8a8d\u77e5\u75c7\u3001\u304c\u3093\u306a\u3069\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>IL-6\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-6\uff09\u3084TNF-\u03b1\uff08\u816b\u760d\u58ca\u6b7b\u56e0\u5b50\u03b1\uff09\u306a\u3069\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u5236\u5fa1\u3059\u308b\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u9577\u5bff\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u4f8b\u3048\u3070\u3001IL-10\u3068\u3044\u3046\u6297\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u767a\u73fe\u304c\u9ad8\u3044\u907a\u4f1d\u5b50\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u708e\u75c7\u306e\u5f71\u97ff\u3092\u53d7\u3051\u306b\u304f\u304f\u3001\u9577\u5bff\u306b\u306a\u308a\u3084\u3059\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3. NK\u7d30\u80de\u6d3b\u6027\u3068\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h4>\n\n\n\n<p>\u30ca\u30c1\u30e5\u30e9\u30eb\u30ad\u30e9\u30fc\uff08NK\uff09\u7d30\u80de\u306f\u3001\u4f53\u5185\u306e\u304c\u3093\u7d30\u80de\u3084\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u7d30\u80de\u3092\u7834\u58ca\u3059\u308b\u50cd\u304d\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002NK\u7d30\u80de\u306e\u6d3b\u6027\u306f\u907a\u4f1d\u7684\u306b\u6c7a\u307e\u308b\u90e8\u5206\u304c\u3042\u308a\u3001NK\u7d30\u80de\u306e\u6a5f\u80fd\u304c\u9ad8\u3044\u907a\u4f1d\u5b50\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u304c\u3093\u3084\u611f\u67d3\u75c7\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001NK\u7d30\u80de\u306e\u50cd\u304d\u3092\u5f37\u5316\u3059\u308b\u907a\u4f1d\u5b50\u6cbb\u7642\u304c\u6a21\u7d22\u3055\u308c\u3066\u304a\u308a\u3001\u7279\u306b\u52a0\u9f62\u306b\u4f34\u3046\u514d\u75ab\u4f4e\u4e0b\u3092\u9632\u3050\u65b0\u305f\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u3068\u5bff\u547d<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"391\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/29807247_m-1024x391.jpg\" alt=\"\" class=\"wp-image-9282\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29807247_m-1024x391.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29807247_m-300x115.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29807247_m-768x293.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29807247_m-1536x586.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29807247_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u751f\u307f\u51fa\u3059\u300c\u767a\u96fb\u6240\u300d\u306e\u3088\u3046\u306a\u5f79\u5272\u3092\u6301\u3063\u3066\u304a\u308a\u3001\u305d\u306eDNA\uff08\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA, mtDNA\uff09\u306f\u6bcd\u89aa\u304b\u3089\u306e\u307f\u907a\u4f1d\u3057\u307e\u3059\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u304c\u6e1b\u5c11\u3057\u3001\u8001\u5316\u304c\u52a0\u901f\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u306e\u5909\u7570\u3068\u8001\u5316<\/strong><\/h4>\n\n\n\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u306b\u306f\u6838DNA\u3068\u306f\u7570\u306a\u308b\u72ec\u81ea\u306e\u907a\u4f1d\u60c5\u5831\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u5909\u7570\u7387\u306f\u975e\u5e38\u306b\u9ad8\u304f\u3001\u3053\u308c\u304c\u8001\u5316\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u306e\u7279\u5b9a\u306e\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\uff08\u907a\u4f1d\u7684\u306a\u578b\uff09\u304c\u9577\u5bff\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u9006\u306b\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u4f4e\u4e0b\u304c\u9032\u3080\u3068\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u5897\u52a0\u3057\u3001\u7d30\u80de\u306e\u8001\u5316\u3084\u75c5\u6c17\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6d3b\u6027\u3092\u7dad\u6301\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<p>PGC-1\u03b1\uff08PPAR\u03b3\u88dc\u52a9\u6d3b\u6027\u5316\u56e0\u5b50-1\u03b1\uff09\u3068\u3044\u3046\u907a\u4f1d\u5b50\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u65b0\u751f\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u8abf\u7bc0\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u9ad8\u3044\u3068\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u304c\u7dad\u6301\u3055\u308c\u3001\u7d30\u80de\u306e\u8001\u5316\u304c\u6291\u3048\u3089\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8fd1\u5e74\u3001PGC-1\u03b1\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u3067\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3057\u3001\u5bff\u547d\u3092\u5ef6\u3070\u3059\u53ef\u80fd\u6027\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u3053\u308c\u306b\u306f\u3001\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u3084NMN\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30e2\u30ce\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff09\u3068\u3044\u3063\u305f\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6442\u53d6\u304c\u6709\u52b9\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u6280\u8853\u3068\u5bff\u547d\u5ef6\u9577\u306e\u53ef\u80fd\u6027<\/strong><\/h3>\n\n\n\n<p>\u8fd1\u5e74\u3001\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306e\u767a\u5c55\u306b\u3088\u308a\u3001\u8001\u5316\u3084\u5bff\u547d\u3092\u5236\u5fa1\u3059\u308b\u907a\u4f1d\u5b50\u306e\u6539\u5909\u304c\u73fe\u5b9f\u5473\u3092\u5e2f\u3073\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. CRISPR-Cas9\u3092\u7528\u3044\u305f\u8001\u5316\u907a\u4f1d\u5b50\u306e\u4fee\u6b63<\/strong><\/h4>\n\n\n\n<p>CRISPR-Cas9\u306f\u3001DNA\u306e\u7279\u5b9a\u306e\u90e8\u5206\u3092\u5207\u308a\u53d6\u3063\u305f\u308a\u3001\u4fee\u6b63\u3057\u305f\u308a\u3067\u304d\u308b\u6280\u8853\u3067\u3059\u3002\u3053\u308c\u3092\u5229\u7528\u3057\u3066\u3001\u8001\u5316\u3092\u52a0\u901f\u3055\u305b\u308b\u907a\u4f1d\u5b50\u3092\u4fee\u6b63\u3059\u308b\u3053\u3068\u3067\u5bff\u547d\u3092\u5ef6\u3070\u3059\u8a66\u307f\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4f8b\u3048\u3070\u3001\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u7814\u7a76\u3067\u306f\u3001\u8001\u5316\u306b\u95a2\u9023\u3059\u308bp16INK4a\u3068\u3044\u3046\u907a\u4f1d\u5b50\u3092\u4e0d\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u306e\u8001\u5316\u3092\u6291\u5236\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li>\u5c06\u6765\u7684\u306b\u306f\u3001CRISPR\u6280\u8853\u3092\u7528\u3044\u305f\u30d2\u30c8\u306e\u8001\u5316\u907a\u4f1d\u5b50\u306e\u4fee\u6b63\u304c\u5b9f\u73fe\u3059\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u907a\u4f1d\u5b50\u6cbb\u7642\u306b\u3088\u308b\u52a0\u9f62\u95a2\u9023\u75be\u60a3\u306e\u4e88\u9632<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u6cbb\u7642\u3092\u5229\u7528\u3057\u3066\u3001\u52a0\u9f62\u306b\u4f34\u3046\u75c5\u6c17\u306e\u767a\u75c7\u3092\u6291\u3048\u308b\u8a66\u307f\u3082\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306a\u3069\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306f\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u907a\u4f1d\u5b50\u6cbb\u7642\u306b\u3088\u3063\u3066\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u304c\u3093\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4e0b\u3052\u308b\u305f\u3081\u306b\u3001\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50\u3092\u6d3b\u6027\u5316\u3059\u308b\u907a\u4f1d\u5b50\u6cbb\u7642\u3082\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u8178\u5185\u7d30\u83cc\u306e\u95a2\u4fc2\uff1a\u5bff\u547d\u3078\u306e\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-1024x683.jpg\" alt=\"\" class=\"wp-image-8852\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u8178\u5185\u7d30\u83cc\u3068\u907a\u4f1d\u5b50\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u5bff\u547d\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u8178\u5185\u7d30\u83cc\u306e\u907a\u4f1d\u7684\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<p>\u8178\u5185\u7d30\u83cc\u306f\u3001\u514d\u75ab\u6a5f\u80fd\u3084\u4ee3\u8b1d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u9577\u5bff\u3068\u306e\u95a2\u9023\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u5b9a\u306e\u8178\u5185\u7d30\u83cc\u3092\u6301\u3064\u500b\u4f53\u306f\u3001\u708e\u75c7\u3092\u6291\u5236\u3057\u3001\u5065\u5eb7\u5bff\u547d\u3092\u5ef6\u3070\u3059\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4f8b\u3048\u3070\u3001100\u6b73\u4ee5\u4e0a\u306e\u9577\u5bff\u8005\u306e\u8178\u5185\u306b\u306f\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3092\u6301\u3064\u30d5\u30a1\u30fc\u30df\u30ad\u30e5\u30fc\u30c6\u30b9\u9580\u306e\u7d30\u83cc\u304c\u591a\u304f\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u98df\u751f\u6d3b\u306b\u3088\u3063\u3066\u6c7a\u307e\u308b\u305f\u3081\u3001\u9069\u5207\u306a\u98df\u4e8b\u7ba1\u7406\u304c\u9577\u5bff\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h4>\n\n\n\n<p>\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u5584\u7389\u83cc\uff09\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u6539\u5584\u3057\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u7279\u5b9a\u306e\u4e73\u9178\u83cc\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u708e\u75c7\u3092\u6291\u3048\u308b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u8178\u5185\u74b0\u5883\u3092\u6574\u3048\u308b\u3053\u3068\u3067\u3001\u8001\u5316\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u65b0\u305f\u306a\u6226\u7565\u304c\u751f\u307e\u308c\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u4ee3\u8b1d\u306e\u95a2\u4fc2\uff1a\u9577\u5bff\u306e\u30e1\u30ab\u30cb\u30ba\u30e0<\/strong><\/h3>\n\n\n\n<p>\u4eba\u9593\u306e\u5bff\u547d\u306b\u306f\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u304c\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u907a\u4f1d\u5b50\u304c\u3069\u306e\u3088\u3046\u306b\u4ee3\u8b1d\u3092\u5236\u5fa1\u3057\u3001\u8001\u5316\u3084\u75be\u60a3\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u306e\u304b\u306b\u3064\u3044\u3066\u3001\u591a\u304f\u306e\u7814\u7a76\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. AMPK\u907a\u4f1d\u5b50\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d<\/strong><\/h4>\n\n\n\n<p>AMPK\uff08AMP\u6d3b\u6027\u5316\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\uff09\u306f\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4e0d\u8db3\u3092\u611f\u77e5\u3057\u3001\u4ee3\u8b1d\u3092\u8abf\u6574\u3059\u308b\u91cd\u8981\u306a\u9175\u7d20\u3067\u3059\u3002AMPK\u3092\u6d3b\u6027\u5316\u3059\u308b\u3068\u3001\u8102\u80aa\u306e\u5206\u89e3\u304c\u4fc3\u9032\u3055\u308c\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u50cd\u304d\u304c\u5411\u4e0a\u3059\u308b\u305f\u3081\u3001\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>AMPK\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u3067\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u304c\u5411\u4e0a\u3057\u3001\u7cd6\u5c3f\u75c5\u306e\u4e88\u9632\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u3084\u65ad\u98df\u306b\u3088\u3063\u3066AMPK\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u5bff\u547d\u5ef6\u9577\u52b9\u679c\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. mTOR\u3068\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<p>mTOR\uff08\u30e1\u30ab\u30cb\u30b9\u30c6\u30a3\u30c3\u30af\u30bf\u30fc\u30b2\u30c3\u30c8\u30aa\u30d6\u30e9\u30d1\u30de\u30a4\u30b7\u30f3\uff09\u306f\u3001\u7d30\u80de\u6210\u9577\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u3092\u5236\u5fa1\u3059\u308b\u7d4c\u8def\u3067\u3042\u308a\u3001\u8001\u5316\u306b\u3082\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002mTOR\u306e\u6d3b\u6027\u304c\u904e\u5270\u306b\u306a\u308b\u3068\u3001\u304c\u3093\u3084\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u305f\u3081\u3001\u9069\u5ea6\u306b\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u5bff\u547d\u5ef6\u9577\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4f4e\u30bf\u30f3\u30d1\u30af\u8cea\u98df\u3084\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u306f\u3001mTOR\u306e\u6291\u5236\u3092\u4fc3\u3057\u3001\u7d30\u80de\u306e\u81ea\u5df1\u4fee\u5fa9\u6a5f\u80fd\u3067\u3042\u308b\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u6d3b\u6027\u5316\u3055\u305b\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u7814\u7a76\u3067\u306f\u3001mTOR\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u5bff\u547d\u304c\u5ef6\u3073\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u7279\u306b\u30e9\u30d1\u30de\u30a4\u30b7\u30f3\u306e\u3088\u3046\u306amTOR\u963b\u5bb3\u5264\u306e\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3. \u30a4\u30f3\u30b9\u30ea\u30f3\/IGF-1\u7d4c\u8def\u3068\u5bff\u547d<\/strong><\/h4>\n\n\n\n<p>\u30a4\u30f3\u30b9\u30ea\u30f3\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u6210\u9577\u56e0\u5b50-1\uff08IGF-1\uff09\u306f\u3001\u4ee3\u8b1d\u3068\u6210\u9577\u3092\u8abf\u7bc0\u3059\u308b\u30db\u30eb\u30e2\u30f3\u3067\u3059\u304c\u3001\u3053\u308c\u3089\u306e\u30b7\u30b0\u30ca\u30eb\u304c\u904e\u5270\u306b\u6d3b\u6027\u5316\u3059\u308b\u3068\u8001\u5316\u304c\u52a0\u901f\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>IGF-1\u306e\u30ec\u30d9\u30eb\u304c\u4f4e\u3044\u500b\u4f53\u3067\u306f\u3001\u7d30\u80de\u306e\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u9ad8\u307e\u308a\u3001\u5bff\u547d\u304c\u5ef6\u3073\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u30d2\u30c8\u306b\u304a\u3044\u3066\u3082\u3001IGF-1\u53d7\u5bb9\u4f53\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u3005\u306f\u9577\u5bff\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u30b9\u30c8\u30ec\u30b9\u8010\u6027\uff1a\u74b0\u5883\u9069\u5fdc\u306e\u9375<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/4376533_m-1024x683.jpg\" alt=\"\u6182\u9b31\u306a\u8868\u60c5\u306a\u5973\u6027\" class=\"wp-image-2810\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4376533_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4376533_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4376533_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4376533_m-1536x1025.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4376533_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u9069\u5fdc\u529b\u306f\u3001\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u5de6\u53f3\u3055\u308c\u307e\u3059\u3002\u74b0\u5883\u30b9\u30c8\u30ec\u30b9\u3078\u306e\u8010\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u306e\u640d\u50b7\u3092\u6291\u3048\u3001\u5bff\u547d\u3092\u5ef6\u3070\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u71b1\u30b7\u30e7\u30c3\u30af\u30bf\u30f3\u30d1\u30af\u8cea\uff08HSP\uff09\u907a\u4f1d\u5b50\u306e\u5f79\u5272<\/strong><\/h4>\n\n\n\n<p>HSP\uff08Heat Shock Protein\uff09\u306f\u3001\u7d30\u80de\u304c\u30b9\u30c8\u30ec\u30b9\u3092\u53d7\u3051\u305f\u969b\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u640d\u50b7\u3092\u9632\u3050\u305f\u3081\u306b\u50cd\u304f\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002HSP\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u3068\u3001\u52a0\u9f62\u306b\u3088\u308b\u7d30\u80de\u306e\u30c0\u30e1\u30fc\u30b8\u3092\u6291\u5236\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>HSP\u306e\u767a\u73fe\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>HSP\u306f\u904b\u52d5\u3084\u9069\u5ea6\u306a\u6e29\u71b1\u523a\u6fc0\uff08\u30b5\u30a6\u30ca\u7642\u6cd5\u306a\u3069\uff09\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. FOXO\u907a\u4f1d\u5b50\u7fa4\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u8010\u6027<\/strong><\/h4>\n\n\n\n<p>FOXO\uff08Forkhead box O\uff09\u907a\u4f1d\u5b50\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306b\u95a2\u4e0e\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u7fa4\u3067\u3042\u308a\u3001\u6297\u9178\u5316\u4f5c\u7528\u3084DNA\u4fee\u5fa9\u3092\u4fc3\u9032\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306bFOXO3\u907a\u4f1d\u5b50\u306f\u3001\u9577\u5bff\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u591a\u304f\u306e\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>FOXO3\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u3005\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3078\u306e\u8010\u6027\u304c\u9ad8\u304f\u3001\u52d5\u8108\u786c\u5316\u3084\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u904b\u52d5\u3084\u65ad\u98df\u306b\u3088\u3063\u3066FOXO3\u304c\u6d3b\u6027\u5316\u3055\u308c\u3001\u8001\u5316\u9632\u6b62\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3. \u30b1\u30c8\u30f3\u4f53\u3068\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5909\u5316<\/strong><\/h4>\n\n\n\n<p>\u65ad\u98df\u3084\u30b1\u30c8\u30b8\u30a7\u30cb\u30c3\u30af\u30c0\u30a4\u30a8\u30c3\u30c8\uff08\u4f4e\u70ad\u6c34\u5316\u7269\u30fb\u9ad8\u8102\u80aa\u98df\uff09\u306b\u3088\u308a\u3001\u4f53\u5185\u3067\u30b1\u30c8\u30f3\u4f53\u304c\u751f\u6210\u3055\u308c\u308b\u3068\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u304c\u5909\u5316\u3057\u3001\u5bff\u547d\u5ef6\u9577\u306b\u6709\u5229\u306a\u72b6\u614b\u304c\u751f\u307e\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30b1\u30c8\u30f3\u4f53\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u6291\u5236\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u3092\u5411\u4e0a\u3055\u305b\u308b\u52b9\u679c\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u7279\u306b\u3001\u03b2-\u30d2\u30c9\u30ed\u30ad\u30b7\u916a\u9178\uff08BHB\uff09\u3068\u3044\u3046\u30b1\u30c8\u30f3\u4f53\u306f\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8abf\u6574\u3057\u3001\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u795e\u7d4c\u7cfb\u306e\u95a2\u4fc2\uff1a\u8a8d\u77e5\u6a5f\u80fd\u3068\u5bff\u547d<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31250640_m-1024x683.jpg\" alt=\"\" class=\"wp-image-8899\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31250640_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31250640_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31250640_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31250640_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31250640_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u52a0\u9f62\u306b\u4f34\u3046\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u306f\u3001\u5bff\u547d\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u91cd\u8981\u306a\u8981\u7d20\u3067\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u306f\u3001\u8133\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306e\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. BDNF\uff08\u8133\u7531\u6765\u795e\u7d4c\u6804\u990a\u56e0\u5b50\uff09\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<p>BDNF\u306f\u3001\u8133\u306e\u795e\u7d4c\u7d30\u80de\u306e\u6210\u9577\u3084\u53ef\u5851\u6027\u3092\u4fc3\u9032\u3059\u308b\u91cd\u8981\u306a\u56e0\u5b50\u3067\u3059\u3002BDNF\u306e\u767a\u73fe\u304c\u9ad8\u3044\u3068\u3001\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3092\u9632\u304e\u3001\u9577\u5bff\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>BDNF\u306f\u3001\u904b\u52d5\u3084\u9069\u5ea6\u306a\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u5206\u6ccc\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u907a\u4f1d\u7684\u306bBDNF\u306e\u767a\u73fe\u304c\u9ad8\u3044\u4eba\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. KLOTHO\u907a\u4f1d\u5b50\u3068\u8a8d\u77e5\u6a5f\u80fd<\/strong><\/h4>\n\n\n\n<p>KLOTHO\u907a\u4f1d\u5b50\u306f\u3001\u9577\u5bff\u306b\u95a2\u4e0e\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u8a8d\u77e5\u6a5f\u80fd\u306e\u7dad\u6301\u306b\u3082\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002KLOTHO\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u3005\u306f\u3001\u8a8d\u77e5\u6a5f\u80fd\u304c\u9ad8\u304f\u3001\u52a0\u9f62\u306b\u3088\u308b\u8133\u306e\u8870\u3048\u3092\u9632\u304e\u3084\u3059\u3044\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>KLOTHO\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306e\u4fee\u5fa9\u3084\u6297\u9178\u5316\u4f5c\u7528\u3092\u6301\u3064\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>KLOTHO\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u3067\u3001\u8a8d\u77e5\u75c7\u306e\u4e88\u9632\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3. \u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u95a2\u9023\u907a\u4f1d\u5b50\uff08APOE\uff09<\/strong><\/h4>\n\n\n\n<p>APOE\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u306b\u5927\u304d\u304f\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>APOE \u03b54<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001\u8a8d\u77e5\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u3001\u8001\u5316\u304c\u9032\u884c\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>APOE \u03b52<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001\u8a8d\u77e5\u6a5f\u80fd\u304c\u7dad\u6301\u3055\u308c\u3084\u3059\u304f\u3001\u9577\u5bff\u306e\u50be\u5411\u304c\u5f37\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7814\u7a76\u304c\u9032\u3080\u3053\u3068\u3067\u3001APOE\u95a2\u9023\u306e\u6cbb\u7642\u6cd5\u3084\u4e88\u9632\u7b56\u304c\u958b\u767a\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u7814\u7a76\u304c\u3082\u305f\u3089\u3059\u672a\u6765<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/23759191_s.jpg\" alt=\"\" class=\"wp-image-1236\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/23759191_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/23759191_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure>\n\n\n\n<p>\u73fe\u5728\u3001\u907a\u4f1d\u5b50\u3068\u5bff\u547d\u306b\u95a2\u3059\u308b\u7814\u7a76\u306f\u6025\u901f\u306b\u9032\u5c55\u3057\u3066\u304a\u308a\u3001\u4eca\u5f8c\u306e\u6280\u8853\u9769\u65b0\u306b\u3088\u3063\u3066\u5bff\u547d\u3092\u5ef6\u3070\u3059\u65b0\u305f\u306a\u65b9\u6cd5\u304c\u751f\u307e\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002CRISPR\u907a\u4f1d\u5b50\u7de8\u96c6\u3084\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u767a\u5c55\u306b\u3088\u308a\u3001\u8001\u5316\u306e\u5236\u5fa1\u304c\u53ef\u80fd\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u907a\u4f1d\u5b50\u304c\u793a\u3059\u9577\u5bff\u306e\u79d8\u8a23\u3092\u7406\u89e3\u3057\u3001\u305d\u308c\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u5065\u5eb7\u3067\u5145\u5b9f\u3057\u305f\u4eba\u751f\u3092\u9001\u308b\u305f\u3081\u306e\u65b0\u305f\u306a\u53ef\u80fd\u6027\u304c\u5e83\u304c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u907a\u4f1d\u5b50\u3068\u5bff\u547d\u306e\u95a2\u4fc2\u3068\u306f\uff1f \u4eba\u9593\u306e\u5bff\u547d\u306f\u3001\u907a\u4f1d\u3068\u74b0\u5883\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u6c7a\u307e\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u9577\u5bff\u3092\u5b9f\u73fe\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u5065\u5eb7\u7684\u306a\u751f\u6d3b\u7fd2\u6163\u304c\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u306f\u5e83\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u8fd1\u5e74\u306e\u7814\u7a76\u306b\u3088\u3063\u3066\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u5bff\u547d\u306e\u9577\u3055\u306b [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":9377,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6],"tags":[52,40,41,59,36,49,34,45,55],"class_list":["post-9376","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-basicknowledge","tag-dna-test","tag-privacy","tag-personalized-medicine","tag-59","tag-gene-testing","tag-gene-analysis","tag-genetic-identification","tag-genetics","tag-genetic-diseases"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/9376","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=9376"}],"version-history":[{"count":1,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/9376\/revisions"}],"predecessor-version":[{"id":9384,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/9376\/revisions\/9384"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/9377"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=9376"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=9376"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=9376"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}