{"id":9438,"date":"2025-03-11T03:29:15","date_gmt":"2025-03-11T03:29:15","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=9438"},"modified":"2025-03-11T03:29:17","modified_gmt":"2025-03-11T03:29:17","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e7%be%8e%e5%ae%b9%ef%bc%9a%e5%80%8b%e5%88%a5%e5%af%be%e5%bf%9c%e3%81%ae%e3%82%b9%e3%82%ad%e3%83%b3%e3%82%b1%e3%82%a2%e6%b3%95","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e7%be%8e%e5%ae%b9%ef%bc%9a%e5%80%8b%e5%88%a5%e5%af%be%e5%bf%9c%e3%81%ae%e3%82%b9%e3%82%ad%e3%83%b3%e3%82%b1%e3%82%a2%e6%b3%95\/","title":{"rendered":"\u907a\u4f1d\u5b50\u3068\u7f8e\u5bb9\uff1a\u500b\u5225\u5bfe\u5fdc\u306e\u30b9\u30ad\u30f3\u30b1\u30a2\u6cd5"},"content":{"rendered":"\n<p>\u8fd1\u5e74\u3001\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u7f8e\u5bb9\u5206\u91ce\u306b\u304a\u3051\u308b\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30b9\u30ad\u30f3\u30b1\u30a2\u304c\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u307e\u3059\u3002\u500b\u3005\u306e\u907a\u4f1d\u7684\u7279\u6027\u306b\u57fa\u3065\u304f\u30b9\u30ad\u30f3\u30b1\u30a2\u306f\u3001\u3088\u308a\u52b9\u679c\u7684\u3067\u52b9\u7387\u7684\u306a\u7f8e\u5bb9\u6cd5\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p><strong>1. \u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u808c\u306e\u8001\u5316<\/strong><\/p>\n\n\n\n<p>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\uff08\u5f8c\u6210\u907a\u4f1d\u5b66\uff09\u306f\u3001\u907a\u4f1d\u5b50\u306e\u914d\u5217\u3092\u5909\u3048\u305a\u306b\u305d\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u4ed5\u7d44\u307f\u3092\u6307\u3057\u307e\u3059\u3002\u8cc7\u751f\u5802\u306e\u7814\u7a76\u306b\u3088\u308c\u3070\u3001\u7d2b\u5916\u7dda\u306a\u3069\u306e\u5916\u7684\u8981\u56e0\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u300cTIPARP\u300d\u304c\u30e1\u30c1\u30eb\u5316\u3055\u308c\u3001\u808c\u306e\u304f\u3059\u307f\u3092\u6291\u5236\u3059\u308b\u60c5\u5831\u304c\u6b63\u5e38\u306b\u4f1d\u9054\u3055\u308c\u306a\u304f\u306a\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>2. \u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30b9\u30ad\u30f3\u30b1\u30a2\u306e\u9032\u5316<\/strong><\/p>\n\n\n\n<p>\u7f8e\u5bb9\u696d\u754c\u3067\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5bfe\u5fdc\u306e\u30b9\u30ad\u30f3\u30b1\u30a2\u30b5\u30fc\u30d3\u30b9\u304c\u62e1\u5927\u3057\u3066\u3044\u307e\u3059\u3002\u6cd5\u79d1\u5b66\u9451\u5b9a\u7814\u7a76\u6240\u306f\u3001\u7f8e\u5bb9\u696d\u754c\u5411\u3051\u306e\u907a\u4f1d\u5b50\u691c\u67fbOEM\u30b5\u30fc\u30d3\u30b9\u3092\u63d0\u4f9b\u3057\u3001\u500b\u3005\u306e\u907a\u4f1d\u60c5\u5831\u306b\u57fa\u3065\u304f\u7f8e\u5bb9\u30a2\u30c9\u30d0\u30a4\u30b9\u3084\u88fd\u54c1\u958b\u767a\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>3. \u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306b\u57fa\u3065\u304f\u88fd\u54c1\u958b\u767a<\/strong><\/p>\n\n\n\n<p>\u30af\u30e9\u30e9\u30f3\u30b9\u306f\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306e\u7814\u7a76\u3092\u57fa\u306b\u3001\u751f\u6d3b\u7fd2\u6163\u306e\u4e71\u308c\u306b\u3088\u308b\u30a8\u30a4\u30b8\u30f3\u30b0\u30b5\u30a4\u30f3\u3092\u4e2d\u548c\u3059\u308b\u7f8e\u5bb9\u6db2\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u540c\u793e\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u4e00\u5375\u6027\u53cc\u751f\u5150\u306e\u8001\u5316\u306e\u5146\u5019\u3092\u6bd4\u8f03\u3057\u3001\u4e0d\u898f\u5247\u306a\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u304c\u808c\u8001\u5316\u3092\u52a0\u901f\u3055\u305b\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u3066\u3044\u307e\u3059\u3002&nbsp;<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-bcc89472-7fff-59ea-4281-da1d028154e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<p><strong>4. \u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u3068\u808c\u306e\u5065\u5eb7<\/strong><\/p>\n\n\n\n<p>Sequential Skin\u793e\u306f\u3001\u808c\u306e\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\uff08\u76ae\u819a\u306b\u5171\u751f\u3059\u308b\u5fae\u751f\u7269\u7fa4\uff09\u3068\u907a\u4f1d\u60c5\u5831\u3092\u89e3\u6790\u3057\u3001\u500b\u5225\u306e\u30b9\u30ad\u30f3\u30b1\u30a2\u30bd\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u808c\u306e\u5065\u5eb7\u72b6\u614b\u3092\u6df1\u304f\u7406\u89e3\u3057\u3001\u6700\u9069\u306a\u30b1\u30a2\u3092\u63d0\u6848\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002&nbsp;<\/p>\n\n\n\n<p><strong>5. \u76ae\u8102RNA\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u306b\u3088\u308b\u808c\u72b6\u614b\u306e\u628a\u63e1<\/strong><\/p>\n\n\n\n<p>\u82b1\u738b\u3068Preferred Networks\u306f\u3001\u76ae\u8102\u304b\u3089\u63a1\u53d6\u3057\u305fRNA\u306e\u89e3\u6790\u6280\u8853\u3092\u5fdc\u7528\u3057\u305f\u7f8e\u5bb9\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u30b5\u30fc\u30d3\u30b9\u306e\u5b9f\u7528\u5316\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3092\u958b\u59cb\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u808c\u5185\u90e8\u306e\u72b6\u614b\u3084\u5c06\u6765\u306e\u808c\u30c0\u30e1\u30fc\u30b8\u306e\u30ea\u30b9\u30af\u8a55\u4fa1\u304c\u53ef\u80fd\u3068\u306a\u308a\u3001\u907a\u4f1d\u60c5\u5831\u3092\u3082\u3068\u306b\u3057\u305f\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u306a\u7f8e\u5bb9\u30a2\u30c9\u30d0\u30a4\u30b9\u3084\u30b9\u30ad\u30f3\u30b1\u30a2\u306e\u63d0\u4f9b\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002&nbsp;<\/p>\n\n\n\n<p><strong>6. \u907a\u4f1d\u5b50\u7814\u7a76\u306b\u57fa\u3065\u304f\u7f8e\u767d\u30b1\u30a2<\/strong><\/p>\n\n\n\n<p>\u30c7\u30a3\u30aa\u30fc\u30eb \u30b9\u30ce\u30fc\u306f\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306b\u7740\u76ee\u3057\u3001\u7d2b\u5916\u7dda\u306a\u3069\u306e\u5916\u7684\u8981\u56e0\u304c\u907a\u4f1d\u5b50\u306e\u30e1\u30c1\u30eb\u5316\u3092\u8a98\u767a\u3057\u3001\u30e1\u30e9\u30cb\u30f3\u306e\u904e\u5270\u751f\u6210\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30b7\u30df\u3084\u304f\u3059\u307f\u306e\u306a\u3044\u660e\u308b\u3044\u808c\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u88fd\u54c1\u958b\u767a\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002&nbsp;<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-bcc89472-7fff-59ea-4281-da1d028154e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<p><strong>7. \u5316\u7ca7\u54c1\u7523\u696d\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u89e3\u6790\u306e\u6d3b\u7528<\/strong><\/p>\n\n\n\n<p>\u7d4c\u6e08\u7523\u696d\u7701\u306e\u300c\u5316\u7ca7\u54c1\u7523\u696d\u30d3\u30b8\u30e7\u30f3\u300d\u3067\u306f\u3001\u907a\u4f1d\u60c5\u5831\u3092\u3082\u3068\u306b\u3057\u305f\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u306a\u7f8e\u5bb9\u30a2\u30c9\u30d0\u30a4\u30b9\u3084\u30b9\u30ad\u30f3\u30b1\u30a2\u306e\u63d0\u4f9b\u304c\u3001\u808c\u72b6\u614b\u306e\u6539\u5584\u3084\u4e88\u9632\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u500b\u3005\u306e\u30cb\u30fc\u30ba\u306b\u5408\u308f\u305b\u305f\u88fd\u54c1\u3084\u30b5\u30fc\u30d3\u30b9\u306e\u63d0\u4f9b\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002&nbsp;<\/p>\n\n\n\n<p><strong>8. \u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u7f8e\u5bb9\u30b5\u30fc\u30d3\u30b9\u306e\u62e1\u5927<\/strong><\/p>\n\n\n\n<p>\u7f8e\u5bb9\u696d\u754c\u3067\u306f\u3001\u500b\u5225\u30cb\u30fc\u30ba\u306b\u5fdc\u3048\u308b\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u88fd\u54c1\u306e\u9700\u8981\u304c\u6025\u901f\u306b\u9ad8\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u6cd5\u79d1\u5b66\u9451\u5b9a\u7814\u7a76\u6240\u306f\u3001\u7f8e\u5bb9\u696d\u754c\u5411\u3051\u306e\u907a\u4f1d\u5b50\u691c\u67fbOEM\u30b5\u30fc\u30d3\u30b9\u3092\u63d0\u4f9b\u3057\u3001\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u7f8e\u5bb9\u30b5\u30fc\u30d3\u30b9\u306e\u62e1\u5927\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u3066\u3044\u307e\u3059\u3002&nbsp;<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-bcc89472-7fff-59ea-4281-da1d028154e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9. DNA\u4fee\u5fa9\u907a\u4f1d\u5b50\u3068\u808c\u306e\u8001\u5316\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/24217586_m-1024x683.jpg\" alt=\"\u65e5\u5098\u3092\u3055\u3057\u3066\u7d2b\u5916\u7dda\u5bfe\u7b56\u3059\u308b\u30a2\u30b8\u30a2\u4eba\u5973\u6027\" class=\"wp-image-9446\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/24217586_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/24217586_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/24217586_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/24217586_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/24217586_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u808c\u306e\u8001\u5316\u306b\u306f\u7d2b\u5916\u7dda\u3084\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u5927\u304d\u304f\u5f71\u97ff\u3057\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306e\u30c0\u30e1\u30fc\u30b8\u3092\u4fee\u5fa9\u3059\u308b\u80fd\u529b\u306b\u306f\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b<strong>DNA\u4fee\u5fa9\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u808c\u306e\u5065\u5eb7\u7dad\u6301\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>9.1 \u4e3b\u8981\u306aDNA\u4fee\u5fa9\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>XPC\uff08\u8272\u7d20\u6027\u4e7e\u76ae\u75c7C\u88dc\u56e0\u5b50\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7d2b\u5916\u7dda\u306b\u3088\u308bDNA\u640d\u50b7\u3092\u4fee\u5fa9\u3059\u308b\u5f79\u5272\u3092\u6301\u3064\u3002<\/li>\n\n\n\n<li>\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u7d2b\u5916\u7dda\u306b\u3088\u308b\u808c\u8001\u5316\u3084\u30b7\u30df\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>SIRT1\uff08\u30b5\u30fc\u30c1\u30e5\u30a4\u30f31\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7d30\u80de\u306e\u8001\u5316\u3092\u6291\u5236\u3057\u3001\u808c\u306e\u5f3e\u529b\u3092\u7dad\u6301\u3059\u308b\u3002<\/li>\n\n\n\n<li>\u8d64\u30ef\u30a4\u30f3\u306a\u3069\u306b\u542b\u307e\u308c\u308b\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u304cSIRT1\u3092\u6d3b\u6027\u5316\u3057\u3001\u808c\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u306b\u5bc4\u4e0e\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>PARP1\uff08\u30dd\u30eaADP\u30ea\u30dc\u30fc\u30b9\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc1\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u6d3b\u6027\u9178\u7d20\u306b\u3088\u308bDNA\u640d\u50b7\u306e\u4fee\u5fa9\u306b\u95a2\u4e0e\u3002<\/li>\n\n\n\n<li>\u9175\u7d20\u6d3b\u6027\u304c\u4f4e\u3044\u3068\u3001\u808c\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u8001\u5316\u304c\u9032\u307f\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>9.2 DNA\u4fee\u5fa9\u3092\u4fc3\u9032\u3059\u308b\u30b9\u30ad\u30f3\u30b1\u30a2\u6210\u5206<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9<\/strong>\uff1aDNA\u4fee\u5fa9\u3092\u52a9\u3051\u3001\u30b7\u30ef\u3084\u30b7\u30df\u306e\u6539\u5584\u306b\u5f79\u7acb\u3064\u3002<\/li>\n\n\n\n<li><strong>\u30d5\u30a7\u30eb\u30e9\u9178<\/strong>\uff1a\u7d2b\u5916\u7dda\u30c0\u30e1\u30fc\u30b8\u3092\u9632\u304e\u3001\u6297\u9178\u5316\u4f5c\u7528\u3092\u767a\u63ee\u3002<\/li>\n\n\n\n<li><strong>\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb<\/strong>\uff1aSIRT1\u3092\u6d3b\u6027\u5316\u3057\u3001\u7d30\u80de\u306e\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-bcc89472-7fff-59ea-4281-da1d028154e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10. \u907a\u4f1d\u5b50\u3068\u808c\u306e\u6c34\u5206\u4fdd\u6301\u6a5f\u80fd<\/strong><\/h3>\n\n\n\n<p>\u808c\u306e\u6c34\u5206\u3092\u4fdd\u6301\u3059\u308b\u80fd\u529b\u306b\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u95a2\u4fc2\u3057\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u3053\u306e\u6a5f\u80fd\u3092\u5de6\u53f3\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>10.1 \u808c\u306e\u4fdd\u6e7f\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FLG\uff08\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u89d2\u8cea\u5c64\u306e\u5f62\u6210\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u3001\u6c34\u5206\u4fdd\u6301\u3092\u52a9\u3051\u308b\u3002<\/li>\n\n\n\n<li>\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u808c\u304c\u4e7e\u71e5\u3057\u3084\u3059\u304f\u306a\u308a\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>AQP3\uff08\u30a2\u30af\u30a2\u30dd\u30ea\u30f33\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7d30\u80de\u819c\u306b\u5b58\u5728\u3057\u3001\u6c34\u5206\u306e\u8f38\u9001\u3092\u8abf\u6574\u3059\u308b\u3002<\/li>\n\n\n\n<li>AQP3\u306e\u767a\u73fe\u91cf\u304c\u4f4e\u3044\u3068\u3001\u808c\u306e\u30cf\u30ea\u3084\u6f64\u3044\u304c\u5931\u308f\u308c\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>10.2 \u808c\u306e\u4fdd\u6e7f\u3092\u9ad8\u3081\u308b\u6210\u5206<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30bb\u30e9\u30df\u30c9<\/strong>\uff1a\u89d2\u8cea\u5c64\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u5f37\u5316\u3057\u3001\u6c34\u5206\u84b8\u767a\u3092\u9632\u3050\u3002<\/li>\n\n\n\n<li><strong>\u30d2\u30a2\u30eb\u30ed\u30f3\u9178<\/strong>\uff1a\u6c34\u5206\u4fdd\u6301\u80fd\u529b\u304c\u9ad8\u304f\u3001\u808c\u306e\u6f64\u3044\u3092\u7dad\u6301\u3002<\/li>\n\n\n\n<li><strong>\u30b0\u30ea\u30bb\u30ea\u30f3<\/strong>\uff1a\u808c\u306e\u6c34\u5206\u3092\u5f15\u304d\u5bc4\u305b\u3001\u4e7e\u71e5\u3092\u9632\u3050\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u7684\u50be\u5411\u3092\u628a\u63e1\u3057\u3001\u9069\u5207\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u88fd\u54c1\u3092\u9078\u629e\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-bcc89472-7fff-59ea-4281-da1d028154e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>11. \u9178\u5316\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-1024x585.jpg\" alt=\"\n\u3046\u3064\u3080\u3044\u3066\u843d\u3061\u8fbc\u3080\u5973\u6027\" class=\"wp-image-9460\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u808c\u306e\u8001\u5316\u3092\u52a0\u901f\u3055\u305b\u308b\u4e3b\u8981\u306a\u8981\u56e0\u3067\u3042\u308a\u3001\u3053\u308c\u306b\u5bfe\u3059\u308b\u8010\u6027\u306b\u306f\u907a\u4f1d\u7684\u306a\u500b\u4eba\u5dee\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>11.1 \u9178\u5316\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3092\u6c7a\u5b9a\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>SOD2\uff08\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u30c7\u30a3\u30b9\u30e0\u30bf\u30fc\u30bc2\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u6d3b\u6027\u9178\u7d20\u3092\u9664\u53bb\u3057\u3001\u7d30\u80de\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u8efd\u6e1b\u3059\u308b\u3002<\/li>\n\n\n\n<li>\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u7d2b\u5916\u7dda\u3084\u74b0\u5883\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u8010\u6027\u304c\u4f4e\u4e0b\u3059\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>GPX1\uff08\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u30da\u30eb\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc1\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u3092\u4ecb\u3057\u3066\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u6291\u5236\u3059\u308b\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3002<\/li>\n\n\n\n<li>\u9175\u7d20\u6d3b\u6027\u304c\u4f4e\u3044\u3068\u3001\u808c\u306e\u8001\u5316\u304c\u9032\u307f\u3084\u3059\u304f\u306a\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>11.2 \u6297\u9178\u5316\u529b\u3092\u9ad8\u3081\u308b\u30b9\u30ad\u30f3\u30b1\u30a2\u6210\u5206<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d3\u30bf\u30df\u30f3C<\/strong>\uff1a\u6d3b\u6027\u9178\u7d20\u3092\u9664\u53bb\u3057\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u751f\u6210\u3092\u30b5\u30dd\u30fc\u30c8\u3002<\/li>\n\n\n\n<li><strong>\u30a2\u30b9\u30bf\u30ad\u30b5\u30f3\u30c1\u30f3<\/strong>\uff1a\u5f37\u529b\u306a\u6297\u9178\u5316\u4f5c\u7528\u3092\u6301\u3061\u3001\u7d2b\u5916\u7dda\u30c0\u30e1\u30fc\u30b8\u3092\u8efd\u6e1b\u3002<\/li>\n\n\n\n<li><strong>\u30c8\u30b3\u30d5\u30a7\u30ed\u30fc\u30eb\uff08\u30d3\u30bf\u30df\u30f3E\uff09<\/strong>\uff1a\u8102\u8cea\u306e\u9178\u5316\u3092\u9632\u304e\u3001\u808c\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u5f37\u5316\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u4f4e\u3044\u3068\u5206\u304b\u3063\u305f\u5834\u5408\u3001\u3053\u308c\u3089\u306e\u6297\u9178\u5316\u6210\u5206\u3092\u7a4d\u6975\u7684\u306b\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12. \u808c\u306e\u5f3e\u529b\u3092\u6c7a\u3081\u308b\u30b3\u30e9\u30fc\u30b2\u30f3\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u808c\u306e\u5f3e\u529b\u3084\u30cf\u30ea\u306f\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u751f\u6210\u91cf\u3068\u5206\u89e3\u901f\u5ea6\u306b\u3088\u3063\u3066\u6c7a\u307e\u308a\u307e\u3059\u304c\u3001\u3053\u308c\u306b\u3082\u907a\u4f1d\u7684\u306a\u500b\u4eba\u5dee\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>12.1 \u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u751f\u6210\u3068\u5206\u89e3\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>COL1A1\uff08\u30b3\u30e9\u30fc\u30b2\u30f3\u30bf\u30a4\u30d71\u907a\u4f1d\u5b50\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u808c\u306e\u30cf\u30ea\u3092\u7dad\u6301\u3059\u308b\u4e3b\u8981\u306a\u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u751f\u6210\u3002<\/li>\n\n\n\n<li>\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u5408\u6210\u91cf\u304c\u6e1b\u5c11\u3057\u3001\u30b7\u30ef\u304c\u3067\u304d\u3084\u3059\u304f\u306a\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>MMP1\uff08\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a4\u30ca\u30fc\u30bc1\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3002<\/li>\n\n\n\n<li>\u6d3b\u6027\u304c\u9ad8\u3059\u304e\u308b\u3068\u3001\u808c\u306e\u5f3e\u529b\u304c\u5931\u308f\u308c\u3084\u3059\u304f\u306a\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>12.2 \u30b3\u30e9\u30fc\u30b2\u30f3\u751f\u6210\u3092\u4fc3\u9032\u3059\u308b\u7f8e\u5bb9\u6210\u5206<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ec\u30c1\u30ce\u30fc\u30eb\uff08\u30d3\u30bf\u30df\u30f3A\uff09<\/strong>\uff1a\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u751f\u6210\u3092\u4fc3\u3057\u3001\u30b7\u30ef\u3092\u9632\u3050\u3002<\/li>\n\n\n\n<li><strong>\u30da\u30d7\u30c1\u30c9<\/strong>\uff1a\u808c\u7d30\u80de\u3092\u523a\u6fc0\u3057\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u5408\u6210\u3092\u30b5\u30dd\u30fc\u30c8\u3002<\/li>\n\n\n\n<li><strong>\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0Q10<\/strong>\uff1a\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u9ad8\u3081\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u7dad\u6301\u3092\u52a9\u3051\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u81ea\u5206\u306b\u5408\u3063\u305f\u30b3\u30e9\u30fc\u30b2\u30f3\u30b1\u30a2\u306e\u65b9\u6cd5\u3092\u9078\u3076\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>13. \u672a\u6765\u306e\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30b9\u30ad\u30f3\u30b1\u30a2<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/02\/30532351_m-1024x683.jpg\" alt=\"\" class=\"wp-image-7378\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/30532351_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/30532351_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/30532351_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/30532351_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/30532351_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u6700\u65b0\u306e\u7814\u7a76\u3067\u306f\u3001<strong>AI\u3068\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u500b\u5225\u5bfe\u5fdc\u306e\u30b9\u30ad\u30f3\u30b1\u30a2<\/strong>\u304c\u5b9f\u7528\u5316\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>13.1 AI\u30b9\u30ad\u30f3\u30b1\u30a2\u8a3a\u65ad\u306e\u9032\u5316<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AI\u304c\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3057\u3001\u6700\u9069\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u3092\u63d0\u6848<\/strong>\u3002<\/li>\n\n\n\n<li><strong>\u30b9\u30de\u30fc\u30c8\u30df\u30e9\u30fc\u304c\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u808c\u306e\u72b6\u614b\u3092\u5206\u6790\u3057\u3001\u30b9\u30ad\u30f3\u30b1\u30a2\u88fd\u54c1\u3092\u63a8\u5968<\/strong>\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>13.2 \u30ca\u30ce\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u3092\u6d3b\u7528\u3057\u305f\u907a\u4f1d\u5b50\u30b9\u30ad\u30f3\u30b1\u30a2<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8abf\u6574\u3059\u308b\u30ca\u30ce\u30ab\u30d7\u30bb\u30eb\u6280\u8853<\/strong>\u304c\u958b\u767a\u3055\u308c\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u90e8\u4f4d\u306b\u7f8e\u5bb9\u6210\u5206\u3092\u5c4a\u3051\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3092\u5fdc\u7528\u3057\u305fDNA\u4fee\u5fa9\u30af\u30ea\u30fc\u30e0<\/strong>\u304c\u3001\u7d2b\u5916\u7dda\u30c0\u30e1\u30fc\u30b8\u3092\u8efd\u6e1b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u4eca\u5f8c\u306e\u6280\u8853\u9769\u65b0\u306b\u3088\u308a\u3001<strong>\u5b8c\u5168\u306b\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u3055\u308c\u305f\u30b9\u30ad\u30f3\u30b1\u30a2<\/strong>\u304c\u4e3b\u6d41\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-bcc89472-7fff-59ea-4281-da1d028154e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>14. \u907a\u4f1d\u5b50\u3068\u708e\u75c7\u53cd\u5fdc\uff1a\u654f\u611f\u808c\u306e\u539f\u56e0\u3092\u63a2\u308b<\/strong><\/h3>\n\n\n\n<p>\u808c\u306e\u708e\u75c7\u53cd\u5fdc\u306f\u3001\u8d64\u307f\u3084\u304b\u3086\u307f\u3001\u5439\u304d\u51fa\u7269\u306a\u3069\u306e\u75c7\u72b6\u3068\u3057\u3066\u73fe\u308c\u307e\u3059\u3002\u3053\u306e\u708e\u75c7\u306e\u5f37\u3055\u3084\u983b\u5ea6\u306b\u306f\u907a\u4f1d\u7684\u8981\u56e0\u304c\u95a2\u4fc2\u3057\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>14.1 \u708e\u75c7\u53cd\u5fdc\u306b\u95a2\u308f\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IL6\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f36\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-6\uff09\u3092\u30b3\u30fc\u30c9\u3057\u3001\u514d\u75ab\u5fdc\u7b54\u3092\u8abf\u7bc0\u3002<\/li>\n\n\n\n<li>\u907a\u4f1d\u7684\u306bIL-6\u306e\u5206\u6ccc\u304c\u591a\u3044\u4eba\u306f\u3001\u654f\u611f\u808c\u306b\u306a\u308a\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>TNF-\u03b1\uff08\u816b\u760d\u58ca\u6b7b\u56e0\u5b50\u03b1\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u5f37\u529b\u306a\u708e\u75c7\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3059\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u7523\u751f\u3002<\/li>\n\n\n\n<li>TNF-\u03b1\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u3068\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3084\u808c\u8352\u308c\u3092\u5f15\u304d\u8d77\u3053\u3057\u3084\u3059\u304f\u306a\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>NLRP3\uff08\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u95a2\u9023\u907a\u4f1d\u5b50\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u708e\u75c7\u6027\u75be\u60a3\u306b\u95a2\u4e0e\u3057\u3001\u6d3b\u6027\u5316\u3055\u308c\u308b\u3068\u904e\u5270\u306a\u514d\u75ab\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002<\/li>\n\n\n\n<li>\u808c\u306e\u8d64\u307f\u3084\u304b\u3086\u307f\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>14.2 \u708e\u75c7\u3092\u6291\u3048\u308b\u30b9\u30ad\u30f3\u30b1\u30a2\u6210\u5206<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9<\/strong>\uff1a\u708e\u75c7\u3092\u93ae\u3081\u3001\u808c\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u5f37\u5316\u3002<\/li>\n\n\n\n<li><strong>\u30c4\u30dc\u30af\u30b5\u30a8\u30ad\u30b9\uff08CICA\uff09<\/strong>\uff1a\u6297\u708e\u75c7\u4f5c\u7528\u304c\u3042\u308a\u3001\u8d64\u307f\u3084\u523a\u6fc0\u3092\u8efd\u6e1b\u3002<\/li>\n\n\n\n<li><strong>\u30ab\u30e2\u30df\u30fc\u30eb\u30a8\u30ad\u30b9<\/strong>\uff1aTNF-\u03b1\u306e\u6d3b\u6027\u3092\u6291\u3048\u3001\u808c\u306e\u93ae\u9759\u52b9\u679c\u3092\u6301\u3064\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u654f\u611f\u808c\u306e\u50be\u5411\u304c\u3042\u308b\u4eba\u306f\u3001\u3053\u308c\u3089\u306e\u6210\u5206\u3092\u542b\u3080\u30b9\u30ad\u30f3\u30b1\u30a2\u88fd\u54c1\u3092\u9078\u3076\u3053\u3068\u3067\u3001\u708e\u75c7\u3092\u9632\u3050\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-bcc89472-7fff-59ea-4281-da1d028154e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>15. \u907a\u4f1d\u5b50\u3068\u76ae\u8102\u5206\u6ccc\uff1a\u8102\u6027\u808c\u30fb\u4e7e\u71e5\u808c\u306e\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/1586412_m-1024x683.jpg\" alt=\"\n\u30cb\u30ad\u30d3\u3092\u6f70\u3059\u7537\u6027\" class=\"wp-image-9467\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/1586412_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/1586412_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/1586412_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/1586412_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/1586412_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u808c\u8cea\u306f\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u306e\u7d44\u307f\u5408\u308f\u305b\u3067\u6c7a\u307e\u308a\u307e\u3059\u304c\u3001\u7279\u306b\u76ae\u8102\u5206\u6ccc\u91cf\u3092\u8abf\u6574\u3059\u308b\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>15.1 \u76ae\u8102\u5206\u6ccc\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MC5R\uff08\u30e1\u30e9\u30ce\u30b3\u30eb\u30c1\u30f35\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u76ae\u8102\u817a\u306e\u6d3b\u6027\u3092\u8abf\u6574\u3057\u3001\u76ae\u8102\u306e\u5206\u6ccc\u91cf\u3092\u6c7a\u5b9a\u3059\u308b\u3002<\/li>\n\n\n\n<li>\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u904e\u5270\u306a\u76ae\u8102\u5206\u6ccc\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u8102\u6027\u808c\u306b\u306a\u308a\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>PPAR\u03b3\uff08\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b3\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u76ae\u8102\u306e\u5408\u6210\u3068\u5206\u89e3\u3092\u8abf\u7bc0\u3057\u3001\u4e7e\u71e5\u808c\u306e\u30ea\u30b9\u30af\u3092\u5de6\u53f3\u3059\u308b\u3002<\/li>\n\n\n\n<li>\u6d3b\u6027\u304c\u4f4e\u3044\u3068\u3001\u808c\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u5f31\u307e\u308a\u3001\u4e7e\u71e5\u808c\u306b\u306a\u308a\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>15.2 \u907a\u4f1d\u5b50\u578b\u5225\u306e\u30b9\u30ad\u30f3\u30b1\u30a2\u6226\u7565<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8102\u6027\u808c\u30bf\u30a4\u30d7\uff08MC5R\u306e\u6d3b\u6027\u304c\u9ad8\u3044\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u30b5\u30ea\u30c1\u30eb\u9178<\/strong>\u3084<strong>\u30b0\u30ea\u30b3\u30fc\u30eb\u9178<\/strong>\u3092\u542b\u3080\u88fd\u54c1\u3067\u76ae\u8102\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3002<\/li>\n\n\n\n<li>\u6cb9\u5206\u306e\u5c11\u306a\u3044\u6c34\u6eb6\u6027\u4fdd\u6e7f\u6210\u5206\uff08\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u3001\u30b0\u30ea\u30bb\u30ea\u30f3\uff09\u3092\u9078\u3076\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u4e7e\u71e5\u808c\u30bf\u30a4\u30d7\uff08PPAR\u03b3\u306e\u6d3b\u6027\u304c\u4f4e\u3044\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u30bb\u30e9\u30df\u30c9<\/strong>\u3084<strong>\u30b9\u30af\u30ef\u30e9\u30f3<\/strong>\u3092\u542b\u3080\u30af\u30ea\u30fc\u30e0\u3067\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u5f37\u5316\u3002<\/li>\n\n\n\n<li>\u6c34\u5206\u3092\u9589\u3058\u8fbc\u3081\u308b<strong>\u30aa\u30a4\u30eb\u30d9\u30fc\u30b9\u306e\u4fdd\u6e7f\u5264<\/strong>\u3092\u4f7f\u7528\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u81ea\u5206\u306e\u808c\u8cea\u306b\u6700\u9069\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u3092\u9078\u629e\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-bcc89472-7fff-59ea-4281-da1d028154e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>16. \u7d2b\u5916\u7dda\u8010\u6027\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u7d2b\u5916\u7dda\u306b\u5bfe\u3059\u308b\u8010\u6027\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u3001\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u30e1\u30e9\u30cb\u30f3\u306e\u751f\u6210\u91cf\u3084DNA\u640d\u50b7\u306e\u4fee\u5fa9\u80fd\u529b\u304c\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>16.1 \u7d2b\u5916\u7dda\u8010\u6027\u3092\u6c7a\u3081\u308b\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MC1R\uff08\u30e1\u30e9\u30ce\u30b3\u30eb\u30c1\u30f31\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30e1\u30e9\u30cb\u30f3\u306e\u751f\u6210\u3092\u8abf\u7bc0\u3057\u3001\u808c\u306e\u7d2b\u5916\u7dda\u8010\u6027\u3092\u6c7a\u5b9a\u3059\u308b\u3002<\/li>\n\n\n\n<li>\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u7d2b\u5916\u7dda\u306b\u3088\u308bDNA\u640d\u50b7\u3092\u53d7\u3051\u3084\u3059\u304f\u3001\u30b7\u30df\u3084\u305d\u3070\u304b\u3059\u304c\u3067\u304d\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>XPA\uff08\u8272\u7d20\u6027\u4e7e\u76ae\u75c7A\u88dc\u56e0\u5b50\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7d2b\u5916\u7dda\u306b\u3088\u308bDNA\u640d\u50b7\u3092\u4fee\u5fa9\u3059\u308b\u6a5f\u80fd\u3092\u6301\u3064\u3002<\/li>\n\n\n\n<li>\u6d3b\u6027\u304c\u4f4e\u3044\u3068\u3001\u7d2b\u5916\u7dda\u30c0\u30e1\u30fc\u30b8\u304c\u84c4\u7a4d\u3057\u3084\u3059\u304f\u306a\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>16.2 \u7d2b\u5916\u7dda\u5bfe\u7b56\u306b\u6700\u9069\u306a\u30b9\u30ad\u30f3\u30b1\u30a2<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>UV\u8010\u6027\u304c\u4f4e\u3044\u30bf\u30a4\u30d7\uff08MC1R\u5909\u7570\u3042\u308a\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>SPF50+\u306e<strong>\u5e83\u57df\u30b9\u30da\u30af\u30c8\u30eb\uff08UVA\/UVB\uff09\u5bfe\u5fdc\u306e\u65e5\u713c\u3051\u6b62\u3081<\/strong>\u3092\u4f7f\u7528\u3002<\/li>\n\n\n\n<li><strong>\u30d3\u30bf\u30df\u30f3C\u3084\u30d5\u30e9\u30fc\u30ec\u30f3<\/strong>\u3092\u542b\u3080\u7f8e\u5bb9\u6db2\u3067\u7d2b\u5916\u7dda\u30c0\u30e1\u30fc\u30b8\u3092\u4fee\u5fa9\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>UV\u8010\u6027\u304c\u9ad8\u3044\u30bf\u30a4\u30d7\uff08MC1R\u5909\u7570\u306a\u3057\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u65e5\u713c\u3051\u3057\u306b\u304f\u3044\u304c\u3001\u6cb9\u65ad\u305b\u305a\u5b9a\u671f\u7684\u306b\u65e5\u713c\u3051\u6b62\u3081\u3092\u4f7f\u7528\u3002<\/li>\n\n\n\n<li><strong>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9<\/strong>\u3067\u30e1\u30e9\u30cb\u30f3\u306e\u751f\u6210\u3092\u6291\u5236\u3057\u3001\u5747\u4e00\u306a\u808c\u8272\u3092\u7dad\u6301\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306b\u3088\u308b\u7d2b\u5916\u7dda\u8010\u6027\u306e\u9055\u3044\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306aUV\u30b1\u30a2\u3092\u5b9f\u8df5\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-bcc89472-7fff-59ea-4281-da1d028154e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>17. \u672a\u6765\u306e\u30b9\u30ad\u30f3\u30b1\u30a2\u6280\u8853\uff1a\u907a\u4f1d\u5b50\u7de8\u96c6\u3068\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31692126_m-1024x683.jpg\" alt=\"\u8a3a\u5bdf\" class=\"wp-image-9474\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31692126_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31692126_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31692126_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31692126_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31692126_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u5c06\u6765\u7684\u306b\u306f<strong>\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853<\/strong>\u3084<strong>\u5e79\u7d30\u80de\u6cbb\u7642<\/strong>\u3092\u5fdc\u7528\u3057\u305f\u30b9\u30ad\u30f3\u30b1\u30a2\u304c\u53ef\u80fd\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>17.1 CRISPR-Cas9\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u30b9\u30ad\u30f3\u30b1\u30a2<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30b3\u30e9\u30fc\u30b2\u30f3\u751f\u6210\u3092\u5f37\u5316\u3059\u308b\u907a\u4f1d\u5b50\u7de8\u96c6<\/strong>\n<ul class=\"wp-block-list\">\n<li>COL1A1\u907a\u4f1d\u5b50\u3092\u6539\u5909\u3057\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u5408\u6210\u3092\u4fc3\u9032\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3092\u6291\u5236\u3059\u308b\u907a\u4f1d\u5b50\u7de8\u96c6<\/strong>\n<ul class=\"wp-block-list\">\n<li>MC1R\u907a\u4f1d\u5b50\u3092\u8abf\u6574\u3057\u3001\u30b7\u30df\u3084\u8272\u7d20\u6c88\u7740\u3092\u9632\u3050\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>17.2 \u5e79\u7d30\u80de\u7531\u6765\u306e\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u6cbb\u7642<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5e79\u7d30\u80de\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u3092\u542b\u3080\u7f8e\u5bb9\u6db2<\/strong>\u304c\u3001\u808c\u7d30\u80de\u306e\u518d\u751f\u3092\u4fc3\u9032\u3002<\/li>\n\n\n\n<li><strong>DNA\u4fee\u5fa9\u6a5f\u80fd\u3092\u6301\u3064\u30a8\u30af\u30bd\u30bd\u30fc\u30e0<\/strong>\u304c\u7d2b\u5916\u7dda\u30c0\u30e1\u30fc\u30b8\u3092\u4fee\u5fa9\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>17.3 AI\u3068\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u306e\u7d71\u5408<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AI\u304c\u500b\u4eba\u306e\u907a\u4f1d\u60c5\u5831\u3092\u89e3\u6790\u3057\u3001\u6700\u9069\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u30d7\u30e9\u30f3\u3092\u63d0\u6848\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u30b9\u30de\u30fc\u30c8\u30c7\u30d0\u30a4\u30b9\u304c\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u808c\u72b6\u614b\u3092\u8a3a\u65ad\u3057\u3001\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u63a8\u5968\u3002<\/strong><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6280\u8853\u306e\u767a\u5c55\u306b\u3088\u308a\u3001<strong>\u5b8c\u5168\u306b\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u3055\u308c\u305f\u30b9\u30ad\u30f3\u30b1\u30a2\u304c\u73fe\u5b9f\u306e\u3082\u306e\u3068\u306a\u308b\u672a\u6765<\/strong>\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-bcc89472-7fff-59ea-4281-da1d028154e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>18. \u907a\u4f1d\u5b50\u3068\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\uff1a\u808c\u306e\u82e5\u3005\u3057\u3055\u3092\u7dad\u6301\u3059\u308b\u9375<\/strong><\/h3>\n\n\n\n<p>\u52a0\u9f62\u306b\u4f34\u3044\u808c\u306e\u30cf\u30ea\u3084\u5f3e\u529b\u304c\u4f4e\u4e0b\u3059\u308b\u4e3b\u306a\u539f\u56e0\u306f\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u6e1b\u5c11\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u84c4\u7a4d\u3001\u7d30\u80de\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u306e\u9045\u308c\u306a\u3069\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u306f\u3001<strong>\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u304c\u6df1\u304f\u95a2\u308f\u3063\u3066\u3044\u307e\u3059<\/strong>\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>18.1 \u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u306b\u95a2\u9023\u3059\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FOXO3\uff08\u9577\u5bff\u907a\u4f1d\u5b50\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7d30\u80de\u306e\u6297\u9178\u5316\u80fd\u529b\u3092\u9ad8\u3081\u3001\u8001\u5316\u3092\u6291\u5236\u3059\u308b\u3002<\/li>\n\n\n\n<li>\u6d3b\u6027\u304c\u4f4e\u3044\u3068\u3001\u808c\u306e\u30cf\u30ea\u3084\u5f3e\u529b\u304c\u5931\u308f\u308c\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>KLOTHO\uff08\u30af\u30ed\u30c8\u30fc\u907a\u4f1d\u5b50\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7d30\u80de\u306e\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u50cd\u304d\u3092\u6301\u3061\u3001\u300c\u82e5\u8fd4\u308a\u907a\u4f1d\u5b50\u300d\u3068\u3082\u547c\u3070\u308c\u308b\u3002<\/li>\n\n\n\n<li>\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u808c\u306e\u6c34\u5206\u4fdd\u6301\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u3001\u30b7\u30ef\u304c\u3067\u304d\u3084\u3059\u304f\u306a\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>SIRT1\uff08\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u907a\u4f1d\u5b50\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7d30\u80de\u306e\u4fee\u5fa9\u6a5f\u80fd\u3092\u9ad8\u3081\u3001\u808c\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u3092\u6b63\u5e38\u5316\u3059\u308b\u3002<\/li>\n\n\n\n<li>\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u306b\u306f\u3001\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u306a\u3069\u306e\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306e\u6442\u53d6\u304c\u6709\u52b9\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-bcc89472-7fff-59ea-4281-da1d028154e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>18.2 \u907a\u4f1d\u5b50\u578b\u5225\u306e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u6226\u7565<\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/32104127_m-1024x585.jpg\" alt=\"\n\u9854\u306b\u7f8e\u5bb9\u6db2\u306e\u30b9\u30d7\u30ec\u30fc\u3092\u304b\u3051\u308b\u5973\u6027\" class=\"wp-image-9481\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32104127_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32104127_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32104127_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32104127_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32104127_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6297\u9178\u5316\u30b1\u30a2\u304c\u5fc5\u8981\u306a\u30bf\u30a4\u30d7\uff08FOXO3\u6d3b\u6027\u304c\u4f4e\u3044\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u30d3\u30bf\u30df\u30f3C\u3084\u30a2\u30b9\u30bf\u30ad\u30b5\u30f3\u30c1\u30f3\u3092\u542b\u3080\u7f8e\u5bb9\u6db2<\/strong>\u3092\u4f7f\u7528\u3002<\/li>\n\n\n\n<li>**\u6297\u9178\u5316\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\uff08\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0Q10\u3001\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\uff09**\u3092\u6442\u53d6\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u7d30\u80de\u306e\u4fee\u5fa9\u3092\u4fc3\u9032\u3059\u308b\u30b1\u30a2\uff08SIRT1\u6d3b\u6027\u304c\u4f4e\u3044\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u3092\u914d\u5408\u3057\u305f\u30af\u30ea\u30fc\u30e0<\/strong>\u3067\u808c\u306e\u4ee3\u8b1d\u3092\u4fc3\u9032\u3002<\/li>\n\n\n\n<li>**\u9069\u5ea6\u306a\u30ab\u30ed\u30ea\u30fc\u5236\u9650\uff0816\u6642\u9593\u30d5\u30a1\u30b9\u30c6\u30a3\u30f3\u30b0\uff09**\u3067\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u907a\u4f1d\u5b50\u3092\u6d3b\u6027\u5316\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u4fdd\u6e7f\u3092\u5f37\u5316\u3059\u308b\u30b1\u30a2\uff08KLOTHO\u6d3b\u6027\u304c\u4f4e\u3044\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u30bb\u30e9\u30df\u30c9\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u3092\u8c4a\u5bcc\u306b\u542b\u3080\u30b9\u30ad\u30f3\u30b1\u30a2<\/strong>\u3067\u6c34\u5206\u4fdd\u6301\u529b\u3092\u5411\u4e0a\u3002<\/li>\n\n\n\n<li><strong>\u6e29\u6cc9\u6c34\u3084\u30df\u30cd\u30e9\u30eb\u8c4a\u5bcc\u306a\u5316\u7ca7\u6c34<\/strong>\u3092\u4f7f\u7528\u3057\u3001\u808c\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u9ad8\u3081\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-bcc89472-7fff-59ea-4281-da1d028154e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>19. \u907a\u4f1d\u5b50\u3068\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\uff1a\u808c\u306e\u65b0\u9673\u4ee3\u8b1d\u3092\u6700\u9069\u5316\u3059\u308b\u65b9\u6cd5<\/strong><\/h3>\n\n\n\n<p>\u808c\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u306f\u7d0428\u65e5\u5468\u671f\u3067\u884c\u308f\u308c\u307e\u3059\u304c\u3001\u3053\u306e\u5468\u671f\u306f\u907a\u4f1d\u7684\u8981\u56e0\u3084\u5e74\u9f62\u306b\u3088\u3063\u3066\u5909\u5316\u3057\u307e\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u306e\u901f\u3055\u3084\u6700\u9069\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u65b9\u6cd5\u3092\u7279\u5b9a\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>19.1 \u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>TGFB1\uff08\u30c8\u30e9\u30f3\u30b9\u30d5\u30a9\u30fc\u30df\u30f3\u30b0\u6210\u9577\u56e0\u5b50\u03b21\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u808c\u306e\u518d\u751f\u3092\u4fc3\u9032\u3057\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u751f\u6210\u3092\u8abf\u6574\u3059\u308b\u3002<\/li>\n\n\n\n<li>\u6d3b\u6027\u304c\u9ad8\u3044\u3068\u3001\u808c\u306e\u751f\u307e\u308c\u5909\u308f\u308a\u304c\u901f\u304f\u3001\u82e5\u3005\u3057\u3044\u808c\u3092\u7dad\u6301\u3057\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>EGFR\uff08\u4e0a\u76ae\u6210\u9577\u56e0\u5b50\u53d7\u5bb9\u4f53\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7d30\u80de\u306e\u5897\u6b96\u3068\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u3092\u5236\u5fa1\u3059\u308b\u3002<\/li>\n\n\n\n<li>\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u808c\u306e\u4ee3\u8b1d\u304c\u9045\u308c\u3001\u304f\u3059\u307f\u3084\u4e7e\u71e5\u304c\u76ee\u7acb\u3061\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>MTOR\uff08\u54fa\u4e73\u985e\u30e9\u30d1\u30de\u30a4\u30b7\u30f3\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u808c\u7d30\u80de\u306e\u6210\u9577\u3068\u5206\u88c2\u306b\u95a2\u4e0e\u3057\u3001\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u3092\u8abf\u6574\u3059\u308b\u3002<\/li>\n\n\n\n<li>\u6d3b\u6027\u304c\u9ad8\u3044\u3068\u3001\u76ae\u8102\u306e\u5206\u6ccc\u304c\u5897\u3048\u3001\u6bdb\u7a74\u306e\u8a70\u307e\u308a\u304c\u8d77\u3053\u308a\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>19.2 \u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u3092\u6574\u3048\u308b\u30b9\u30ad\u30f3\u30b1\u30a2<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u304c\u9045\u3044\u30bf\u30a4\u30d7\uff08EGFR\u6d3b\u6027\u304c\u4f4e\u3044\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u30d4\u30fc\u30ea\u30f3\u30b0\u6210\u5206\uff08AHA\u3001BHA\uff09\u3092\u542b\u3080\u5316\u7ca7\u54c1<\/strong>\u3092\u4f7f\u7528\u3057\u3001\u89d2\u8cea\u9664\u53bb\u3092\u4fc3\u9032\u3002<\/li>\n\n\n\n<li><strong>\u30ec\u30c1\u30ce\u30fc\u30eb\u914d\u5408\u306e\u7f8e\u5bb9\u6db2<\/strong>\u3067\u808c\u7d30\u80de\u306e\u518d\u751f\u3092\u30b5\u30dd\u30fc\u30c8\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u304c\u901f\u3059\u304e\u308b\u30bf\u30a4\u30d7\uff08TGFB1\u6d3b\u6027\u304c\u9ad8\u3044\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>**\u93ae\u9759\u6210\u5206\uff08\u30a2\u30ed\u30a8\u30d9\u30e9\u3001\u30ab\u30e2\u30df\u30fc\u30eb\u30a8\u30ad\u30b9\uff09**\u3092\u914d\u5408\u3057\u305f\u30b9\u30ad\u30f3\u30b1\u30a2\u3092\u4f7f\u7528\u3002<\/li>\n\n\n\n<li><strong>\u30d3\u30bf\u30df\u30f3E\u3001\u30bb\u30e9\u30df\u30c9\u914d\u5408\u306e\u4fdd\u6e7f\u30af\u30ea\u30fc\u30e0<\/strong>\u3067\u808c\u30d0\u30ea\u30a2\u3092\u5f37\u5316\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u76ae\u8102\u904e\u591a\u306e\u30bf\u30a4\u30d7\uff08MTOR\u6d3b\u6027\u304c\u9ad8\u3044\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u4e9c\u925b\u3084\u30b0\u30ea\u30b3\u30fc\u30eb\u9178\u3092\u542b\u3080\u30b9\u30ad\u30f3\u30b1\u30a2<\/strong>\u3067\u76ae\u8102\u5206\u6ccc\u3092\u8abf\u6574\u3002<\/li>\n\n\n\n<li><strong>\u30aa\u30a4\u30eb\u30d5\u30ea\u30fc\u306e\u5316\u7ca7\u54c1<\/strong>\u3092\u4f7f\u7528\u3057\u3001\u6bdb\u7a74\u306e\u8a70\u307e\u308a\u3092\u9632\u3050\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-bcc89472-7fff-59ea-4281-da1d028154e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>20. \u76ae\u819a\u5e38\u5728\u83cc\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2\uff1a\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u30b9\u30ad\u30f3\u30b1\u30a2\u306e\u6700\u524d\u7dda<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31075536_m-1024x585.jpg\" alt=\"\n\u5b9f\u9a13\u30b5\u30f3\u30d7\u30eb\" class=\"wp-image-9488\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31075536_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31075536_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31075536_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31075536_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31075536_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u76ae\u819a\u306b\u306f\u6570\u5341\u7a2e\u985e\u306e\u5fae\u751f\u7269\u304c\u5171\u751f\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e**\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\uff08\u76ae\u819a\u5e38\u5728\u83cc\uff09**\u304c\u808c\u306e\u5065\u5eb7\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u308a\u3001\u76ae\u819a\u5e38\u5728\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u6700\u8fd1\u306e\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>20.1 \u76ae\u819a\u5e38\u5728\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u6c7a\u3081\u308b\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FLG\uff08\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u89d2\u8cea\u7d30\u80de\u306e\u5f62\u6210\u306b\u95a2\u4e0e\u3057\u3001\u808c\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u7dad\u6301\u3059\u308b\u3002<\/li>\n\n\n\n<li>\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u808c\u304c\u4e7e\u71e5\u3057\u3084\u3059\u304f\u3001\u5e38\u5728\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>IL17A\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f317A\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u514d\u75ab\u5fdc\u7b54\u3092\u8abf\u6574\u3057\u3001\u808c\u306e\u708e\u75c7\u3092\u6291\u3048\u308b\u3002<\/li>\n\n\n\n<li>\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u30a2\u30af\u30cd\u83cc\u304c\u5897\u6b96\u3057\u3084\u3059\u304f\u3001\u30cb\u30ad\u30d3\u304c\u3067\u304d\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>20.2 \u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u3092\u6574\u3048\u308b\u30b9\u30ad\u30f3\u30b1\u30a2<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u4e73\u9178\u83cc\u3001\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u5584\u7389\u83cc\u3092\u5897\u3084\u3057\u3001\u76ae\u819a\u306e\u5065\u5eb7\u3092\u4fdd\u3064\u3002<\/li>\n\n\n\n<li><strong>\u767a\u9175\u30a8\u30ad\u30b9\u3092\u542b\u3080\u5316\u7ca7\u6c34\u3084\u7f8e\u5bb9\u6db2<\/strong>\u3092\u6d3b\u7528\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u30aa\u30ea\u30b4\u7cd6\u3001\u30d5\u30e9\u30af\u30c8\u30aa\u30ea\u30b4\u7cd6\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u76ae\u819a\u306e\u5584\u7389\u83cc\u306e\u30a8\u30b5\u3068\u306a\u308a\u3001\u808c\u74b0\u5883\u3092\u6539\u5584\u3002<\/li>\n\n\n\n<li><strong>\u30e8\u30fc\u30b0\u30eb\u30c8\u7531\u6765\u306e\u30b9\u30ad\u30f3\u30b1\u30a2\u88fd\u54c1<\/strong>\u3092\u4f7f\u7528\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30d0\u30af\u30c6\u30ea\u30aa\u30d5\u30a1\u30fc\u30b8\u7642\u6cd5\uff08\u76ae\u819a\u7d30\u83cc\u3092\u8abf\u6574\u3059\u308b\u6700\u65b0\u6280\u8853\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30a2\u30af\u30cd\u83cc\u306a\u3069\u306e\u7279\u5b9a\u306e\u7d30\u83cc\u306e\u307f\u3092\u9664\u53bb\u3057\u3001\u30d0\u30e9\u30f3\u30b9\u3092\u6574\u3048\u308b\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u3002<\/li>\n\n\n\n<li>2025\u5e74\u307e\u3067\u306b\u5e02\u8ca9\u5316\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-bcc89472-7fff-59ea-4281-da1d028154e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>\u307e\u3068\u3081<\/strong><\/p>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u5316\u306b\u3088\u308a\u3001\u30b9\u30ad\u30f3\u30b1\u30a2\u306f\u500b\u5225\u5bfe\u5fdc\u306e\u6642\u4ee3\u3078\u3068\u79fb\u884c\u3057\u3066\u3044\u307e\u3059\u3002DNA\u4fee\u5fa9\u3084\u76ae\u8102\u5206\u6ccc\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3001\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u901f\u5ea6\u306a\u3069\u3001\u808c\u8cea\u3092\u6c7a\u5b9a\u3059\u308b\u591a\u304f\u306e\u8981\u56e0\u304c\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u89e3\u660e\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30b9\u30ad\u30f3\u30b1\u30a2\u304c\u53ef\u80fd\u306b\u306a\u308a\u3001\u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u6700\u9069\u306a\u6210\u5206\u3084\u7f8e\u5bb9\u6cd5\u3092\u9078\u3076\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3055\u3089\u306b\u3001AI\u8a3a\u65ad\u3084\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u89e3\u6790\u3001\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306e\u767a\u5c55\u306b\u3088\u308a\u3001\u672a\u6765\u306e\u30b9\u30ad\u30f3\u30b1\u30a2\u306f\u3088\u308a\u7cbe\u5bc6\u304b\u3064\u52b9\u679c\u7684\u306b\u306a\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n<p>\u8a73\u3057\u304f\u306f <a href=\"https:\/\/www.hiro-clinic.or.jp\/gene\/clinic\/\">\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u5168\u56fd\u306e\u30af\u30ea\u30cb\u30c3\u30af\u4e00\u89a7<\/a> 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