{"id":957,"date":"2024-12-18T01:42:01","date_gmt":"2024-12-18T01:42:01","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=957"},"modified":"2025-01-31T01:29:29","modified_gmt":"2025-01-31T01:29:29","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e5%85%8d%e7%96%ab%e7%b3%bb%ef%bc%9a%e7%97%85%e6%b0%97%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e6%8a%b5%e6%8a%97%e5%8a%9b%e3%81%ae%e9%81%95%e3%81%84%e3%82%92%e6%8e%a2","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e5%85%8d%e7%96%ab%e7%b3%bb%ef%bc%9a%e7%97%85%e6%b0%97%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e6%8a%b5%e6%8a%97%e5%8a%9b%e3%81%ae%e9%81%95%e3%81%84%e3%82%92%e6%8e%a2\/","title":{"rendered":"\u907a\u4f1d\u5b50\u3068\u514d\u75ab\u7cfb\uff1a\u75c5\u6c17\u306b\u5bfe\u3059\u308b\u62b5\u6297\u529b\u306e\u9055\u3044\u3092\u63a2\u308b"},"content":{"rendered":"\n<p>\u514d\u75ab\u7cfb\u306f\u79c1\u305f\u3061\u306e\u4f53\u3092\u30a6\u30a4\u30eb\u30b9\u3084\u7d30\u83cc\u306a\u3069\u306e\u5916\u6575\u304b\u3089\u5b88\u308b\u91cd\u8981\u306a\u9632\u5fa1\u6a5f\u69cb\u3067\u3059\u304c\u3001\u305d\u306e\u50cd\u304d\u65b9\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u9055\u3044\u306e\u80cc\u666f\u306b\u306f<strong>\u907a\u4f1d\u5b50\u304c\u6df1\u304f\u95a2\u4e0e<\/strong>\u3057\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u7684\u8981\u56e0\u304c\u514d\u75ab\u53cd\u5fdc\u306e\u5f37\u3055\u3084\u75c5\u6c17\u3078\u306e\u62b5\u6297\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001<strong>\u514d\u75ab\u7cfb\u306b\u95a2\u4e0e\u3059\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50\u3001\u907a\u4f1d\u7684\u591a\u69d8\u6027\u304c\u611f\u67d3\u75c7\u3084\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3001\u6700\u65b0\u306e\u7814\u7a76\u6210\u679c<\/strong>\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-2887cae1-7fff-c98b-c0c9-daf40835560e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u514d\u75ab\u7cfb\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u514d\u75ab\u7cfb\u306e\u57fa\u672c\u30e1\u30ab\u30cb\u30ba\u30e0<\/strong><\/h4>\n\n\n\n<p>\u514d\u75ab\u7cfb\u306f\u3001**\u81ea\u7136\u514d\u75ab\uff08\u5148\u5929\u6027\u514d\u75ab\uff09\u3068\u7372\u5f97\u514d\u75ab\uff08\u9069\u5fdc\u514d\u75ab\uff09**\u306e2\u3064\u306e\u30b7\u30b9\u30c6\u30e0\u304b\u3089\u6210\u308a\u7acb\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u81ea\u7136\u514d\u75ab<\/strong>\uff1a\u75c5\u539f\u4f53\u304c\u4f53\u5185\u306b\u4fb5\u5165\u3057\u305f\u969b\u306b\u5373\u5ea7\u306b\u53cd\u5fdc\u3057\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3084\u597d\u4e2d\u7403\u306a\u3069\u304c\u50cd\u3044\u3066\u7570\u7269\u3092\u6392\u9664\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u7372\u5f97\u514d\u75ab<\/strong>\uff1a\u7279\u5b9a\u306e\u75c5\u539f\u4f53\u306b\u5bfe\u3057\u3066<strong>B\u7d30\u80de\u3084T\u7d30\u80de\u304c\u6297\u4f53\u3092\u751f\u6210<\/strong>\u3057\u3001\u9577\u671f\u7684\u306a\u514d\u75ab\u8a18\u61b6\u3092\u5f62\u6210\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u3092\u8abf\u6574\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u306e\u304c\u3001\u907a\u4f1d\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u514d\u75ab\u306b\u95a2\u4e0e\u3059\u308b\u4e3b\u306a\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<p>\u514d\u75ab\u7cfb\u3092\u69cb\u7bc9\u3059\u308b\u907a\u4f1d\u5b50\u306e\u4e2d\u3067\u3001\u7279\u306b\u91cd\u8981\u306a\u306e\u304c<strong>HLA\u907a\u4f1d\u5b50\u3001TLR\u907a\u4f1d\u5b50\u3001IFNG\u907a\u4f1d\u5b50<\/strong>\u306a\u3069\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>HLA\uff08\u30d2\u30c8\u767d\u8840\u7403\u6297\u539f\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>HLA\u907a\u4f1d\u5b50\u306f\u3001<strong>\u514d\u75ab\u5fdc\u7b54\u3092\u8abf\u7bc0\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u7fa4<\/strong>\u3067\u3001\u75c5\u539f\u4f53\u3092\u8a8d\u8b58\u3057\u3001T\u7d30\u80de\u306b\u7570\u7269\u306e\u5b58\u5728\u3092\u4f1d\u3048\u307e\u3059\u3002HLA\u907a\u4f1d\u5b50\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u3001<strong>\u611f\u67d3\u75c7\u306e\u30ea\u30b9\u30af\u3084\u30ef\u30af\u30c1\u30f3\u3078\u306e\u53cd\u5fdc\u304c\u7570\u306a\u308b<\/strong>\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/ni\">\u53c2\u8003\uff1aNature Immunology<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>TLR\uff08\u30c8\u30eb\u69d8\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>TLR\u907a\u4f1d\u5b50\u306f\u3001\u75c5\u539f\u4f53\u306e\u7279\u5fb4\u3092\u611f\u77e5\u3057\u3001<strong>\u81ea\u7136\u514d\u75ab\u306e\u6d3b\u6027\u5316<\/strong>\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002TLR4\u306e\u5909\u7570\u306f\u3001\u7d30\u83cc\u611f\u67d3\u306b\u5bfe\u3059\u308b\u53cd\u5fdc\u6027\u3092\u5909\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.jimmunol.org\/\">\u53c2\u8003\uff1aJournal of Immunology<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>IFNG\uff08\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u03b3\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>IFNG\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u6642\u306b\u5f37\u529b\u306a\u514d\u75ab\u5fdc\u7b54\u3092\u5f15\u304d\u8d77\u3053\u3059\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u767a\u73fe\u91cf\u306e\u9055\u3044\u304c\u611f\u67d3\u75c7\u3078\u306e\u62b5\u6297\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-2887cae1-7fff-c98b-c0c9-daf40835560e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u7684\u591a\u69d8\u6027\u3068\u75c5\u6c17\u3078\u306e\u62b5\u6297\u529b<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u611f\u67d3\u75c7\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h4>\n\n\n\n<p>\u4eba\u985e\u306e\u6b74\u53f2\u306e\u4e2d\u3067\u3001\u30da\u30b9\u30c8\u3084\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u3001COVID-19\u306a\u3069\u306e\u611f\u67d3\u75c7\u304c\u6d41\u884c\u3059\u308b\u305f\u3073\u306b\u3001<strong>\u7279\u5b9a\u306e\u907a\u4f1d\u7684\u8981\u56e0\u3092\u6301\u3064\u4eba\u304c\u751f\u5b58\u3057\u3084\u3059\u304f\u306a\u308b\u300c\u81ea\u7136\u9078\u629e\u300d\u304c\u50cd\u3044\u3066\u304d\u305f<\/strong>\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>HLA\u907a\u4f1d\u5b50\u3068\u30a6\u30a4\u30eb\u30b9\u611f\u67d3<\/strong><strong><br><\/strong>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001HLA-B*57\u3092\u6301\u3064\u4eba\u306f<strong>HIV\u611f\u67d3\u306b\u5bfe\u3057\u3066\u62b5\u6297\u529b\u304c\u9ad8\u3044<\/strong>\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001HLA-DRB1\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u306f<strong>COVID-19\u306e\u91cd\u75c7\u5316\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b<\/strong>\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\uff1aThe Lancet Infectious Diseases\uff09\u3002<\/li>\n\n\n\n<li><strong>TLR\u907a\u4f1d\u5b50\u3068\u7d30\u83cc\u611f\u67d3<\/strong><strong><br><\/strong>TLR4\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u5909\u7570\u306f\u3001\u7d30\u83cc\u6027\u6557\u8840\u75c7\u306e\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u5225\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u30de\u30e9\u30ea\u30a2\u306a\u3069\u306e\u611f\u67d3\u75c7\u306b\u5bfe\u3059\u308b\u8010\u6027\u304c\u9ad8\u307e\u308b\u3053\u3068\u3082\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3068\u306e\u95a2\u9023<\/strong><\/h4>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001<strong>\u514d\u75ab\u7cfb\u304c\u904e\u5270\u306b\u6d3b\u6027\u5316\u3059\u308b\u3068\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3092\u5f15\u304d\u8d77\u3053\u3059\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059<\/strong>\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>HLA\u907a\u4f1d\u5b50\u3068\u81ea\u5df1\u514d\u75ab\u75be\u60a3<\/strong><strong><br><\/strong>HLA-DR4\u3092\u6301\u3064\u4eba\u306f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001HLA-DQ2\u3084HLA-DQ8\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u306f\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\uff08\u5c0f\u9ea6\u30b0\u30eb\u30c6\u30f3\u306b\u5bfe\u3059\u308b\u81ea\u5df1\u514d\u75ab\u75be\u60a3\uff09\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/ng\">\u53c2\u8003\uff1aNature Genetics<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>PTPN22\u907a\u4f1d\u5b50\u3068\u81ea\u5df1\u514d\u75ab\u75be\u60a3<\/strong><strong><br><\/strong>PTPN22\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u30011\u578b\u7cd6\u5c3f\u75c5\u3084\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\uff08SLE\uff09\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4e0a\u6607\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-2887cae1-7fff-c98b-c0c9-daf40835560e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3092\u6d3b\u7528\u3057\u305f\u514d\u75ab\u533b\u7642\u306e\u672a\u6765<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"681\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/31061071_m-1024x681.jpg\" alt=\"\u6ce8\u5c04\u3000\u5973\u6027\" class=\"wp-image-2953\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31061071_m-1024x681.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31061071_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31061071_m-768x511.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31061071_m-1536x1022.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31061071_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u500b\u5225\u5316\u30ef\u30af\u30c1\u30f3\u3068\u514d\u75ab\u6cbb\u7642<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u500b\u3005\u306e\u514d\u75ab\u7cfb\u306b\u6700\u9069\u306a\u30ef\u30af\u30c1\u30f3\u3084\u6cbb\u7642\u6cd5\u3092\u958b\u767a\u3059\u308b\u53d6\u308a\u7d44\u307f\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059<\/strong>\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>mRNA\u30ef\u30af\u30c1\u30f3\u306e\u6700\u9069\u5316<\/strong><strong><br><\/strong>\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306emRNA\u30ef\u30af\u30c1\u30f3\u306e\u958b\u767a\u306b\u304a\u3044\u3066\u3001\u4e00\u90e8\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u304c\u3088\u308a\u5f37\u3044\u514d\u75ab\u5fdc\u7b54\u3092\u793a\u3059\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\u3002\u4eca\u5f8c\u3001<strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u3066\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u30ef\u30af\u30c1\u30f3\u3092\u63d0\u4f9b\u3059\u308b\u6280\u8853\u304c\u9032\u5316\u3059\u308b\u53ef\u80fd\u6027<\/strong>\u304c\u3042\u308a\u307e\u3059\uff08\u53c2\u8003\uff1aCell Reports Medicine\uff09\u3002<\/li>\n\n\n\n<li><strong>CAR-T\u7d30\u80de\u7642\u6cd5\u3068\u304c\u3093\u514d\u75ab\u6cbb\u7642<\/strong><strong><br><\/strong>\u514d\u75ab\u7cfb\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u89e3\u6790\u3057\u3001\u60a3\u8005\u81ea\u8eab\u306eT\u7d30\u80de\u3092\u6539\u5909\u3057\u3066\u304c\u3093\u3092\u653b\u6483\u3059\u308bCAR-T\u7d30\u80de\u7642\u6cd5\u304c\u6025\u901f\u306b\u767a\u5c55\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u767d\u8840\u75c5\u3084\u30ea\u30f3\u30d1\u816b\u306a\u3069\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u975e\u5e38\u306b\u6709\u671b\u306a\u6280\u8853\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\uff1aScience Translational Medicine\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u8ffd\u52a0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u30ea\u30f3\u30af<\/strong><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nature.com\/ni\">Nature Immunology \u2013 HLA\u907a\u4f1d\u5b50\u3068\u514d\u75ab\u5fdc\u7b54<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.jimmunol.org\/\">Journal of Immunology \u2013 TLR\u907a\u4f1d\u5b50\u3068\u81ea\u7136\u514d\u75ab<\/a><\/li>\n\n\n\n<li>The Lancet Infectious Diseases \u2013 HLA\u907a\u4f1d\u5b50\u3068COVID-19\u306e\u91cd\u75c7\u5316\u30ea\u30b9\u30af<\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/ng\">Nature Genetics \u2013 HLA\u907a\u4f1d\u5b50\u3068\u81ea\u5df1\u514d\u75ab\u75be\u60a3<\/a><\/li>\n\n\n\n<li>Cell Reports Medicine \u2013 \u907a\u4f1d\u5b50\u3068\u30ef\u30af\u30c1\u30f3\u5fdc\u7b54<\/li>\n<\/ol>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u514d\u75ab\u7cfb\uff1a\u65b0\u305f\u306a\u7814\u7a76\u3068\u81e8\u5e8a\u5fdc\u7528\u306e\u5c55\u671b<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u3068\u514d\u75ab\u7cfb\u306e\u95a2\u4fc2\u306f\u3001\u611f\u67d3\u75c7\u3084\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u6c7a\u5b9a\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u3082\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u307e\u3059\u3002\u3053\u3053\u3067\u306f\u3001\u6700\u65b0\u306e\u7814\u7a76\u6210\u679c\u3092\u3082\u3068\u306b\u3001<strong>\u907a\u4f1d\u5b50\u3068\u514d\u75ab\u306e\u76f8\u4e92\u4f5c\u7528\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u9032\u5c55\u3001\u514d\u75ab\u7cfb\u306e\u907a\u4f1d\u7684\u591a\u69d8\u6027\u3092\u6d3b\u7528\u3057\u305f\u65b0\u6280\u8853<\/strong>\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u907a\u4f1d\u5b50\u3068\u514d\u75ab\u53cd\u5fdc\u306e\u500b\u4eba\u5dee<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1-1. \u514d\u75ab\u5fdc\u7b54\u306e\u5f37\u3055\u3092\u6c7a\u3081\u308b\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h4>\n\n\n\n<p>\u514d\u75ab\u7cfb\u306e\u50cd\u304d\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u3001\u305d\u306e\u9055\u3044\u306f\u907a\u4f1d\u7684\u80cc\u666f\u306b\u3088\u308b\u3082\u306e\u304c\u5927\u304d\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001<strong>HLA\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u306f\u3001\u514d\u75ab\u5fdc\u7b54\u306e\u5f37\u3055\u3084\u75c5\u539f\u4f53\u3078\u306e\u611f\u53d7\u6027\u3092\u6c7a\u5b9a\u3059\u308b\u91cd\u8981\u306a\u8981\u7d20<\/strong>\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>HLA\u907a\u4f1d\u5b50\u3068\u30ef\u30af\u30c1\u30f3\u5fdc\u7b54<\/strong><strong><br><\/strong>\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306e\u514d\u75ab\u5fdc\u7b54\u306e\u5f37\u3055\u306f\u3001HLA\u306e\u591a\u578b\u306b\u3088\u3063\u3066\u5909\u308f\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001<strong>HLA-DQB1*06:02\u3092\u6301\u3064\u4eba\u306f\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30ef\u30af\u30c1\u30f3\u306b\u5bfe\u3059\u308b\u6297\u4f53\u5fdc\u7b54\u304c\u5f37\u3044<\/strong>\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\uff1aFrontiers in Immunology\uff09\u3002<\/li>\n\n\n\n<li><strong>IL6\u907a\u4f1d\u5b50\u3068\u708e\u75c7\u53cd\u5fdc<\/strong><strong><br><\/strong>IL6\u907a\u4f1d\u5b50\u306f\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-6\uff09\u306e\u7523\u751f\u306b\u95a2\u4e0e\u3057\u3001\u305d\u306e\u591a\u578b\u306b\u3088\u3063\u3066\u708e\u75c7\u53cd\u5fdc\u306e\u5f37\u3055\u304c\u7570\u306a\u308a\u307e\u3059\u3002IL6\u306e\u904e\u5270\u767a\u73fe\u306f<strong>\u6162\u6027\u708e\u75c7\u3084\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b<\/strong>\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1-2. \u8178\u5185\u30d5\u30ed\u30fc\u30e9\u3068\u514d\u75ab\u907a\u4f1d\u5b66<\/strong><\/h4>\n\n\n\n<p>\u8fd1\u5e74\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\uff08\u8178\u5185\u7d30\u83cc\u53e2\uff09\u3068\u514d\u75ab\u907a\u4f1d\u5b66\u306e\u95a2\u9023\u6027\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u8178\u5185\u7d30\u83cc\u306e\u69cb\u6210\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u305d\u308c\u304c\u514d\u75ab\u5fdc\u7b54\u306e\u9055\u3044\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FUT2\u907a\u4f1d\u5b50\u3068\u8178\u5185\u7d30\u83cc<\/strong><strong><br><\/strong>FUT2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u308a\u3001\u8178\u5185\u306e\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\u306e\u91cf\u304c\u7570\u306a\u308a\u3001\u305d\u308c\u304c\u514d\u75ab\u7cfb\u306e\u6d3b\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/nmicrobiol\">\u53c2\u8003\uff1aNature Microbiology<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>NOD2\u907a\u4f1d\u5b50\u3068\u708e\u75c7\u6027\u8178\u75be\u60a3\uff08IBD\uff09<\/strong><strong><br><\/strong>NOD2\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u30af\u30ed\u30fc\u30f3\u75c5\u306a\u3069\u306e\u708e\u75c7\u6027\u8178\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u7570\u306a\u308b\u305f\u3081\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u611f\u67d3\u75c7\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u8a55\u4fa1<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/28313527_m-1024x683.jpg\" alt=\"\u54b3\u3092\u3059\u308b\u5973\u6027\" class=\"wp-image-3312\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/28313527_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/28313527_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/28313527_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/28313527_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/28313527_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2-1. \u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08COVID-19\uff09\u3068\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<p>COVID-19\u306e\u91cd\u75c7\u5316\u30ea\u30b9\u30af\u306b\u306f\u907a\u4f1d\u7684\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001<strong>\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u591a\u578b\u304c\u75c7\u72b6\u306e\u91cd\u3055\u3092\u6c7a\u5b9a\u3059\u308b<\/strong>\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>HLA\u907a\u4f1d\u5b50\u3068COVID-19\u306e\u91cd\u75c7\u5ea6<\/strong><strong><br><\/strong>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001HLA-B*46:01\u3092\u6301\u3064\u4eba\u306fCOVID-19\u306b\u5bfe\u3059\u308b\u514d\u75ab\u5fdc\u7b54\u304c\u5f31\u304f\u3001\u91cd\u75c7\u5316\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nejm.org\/\">\u53c2\u8003\uff1aNew England Journal of Medicine<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>O\u578b\u8840\u6db2\u578b\u3068\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b<\/strong><strong><br><\/strong>ABO\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u304cCOVID-19\u306e\u611f\u67d3\u7387\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001<strong>O\u578b\u306e\u4eba\u306f\u611f\u67d3\u30ea\u30b9\u30af\u304c\u4f4e\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b<\/strong>\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2-2. \u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308b\u611f\u67d3\u75c7\u30ea\u30b9\u30af\u306e\u8a55\u4fa1<\/strong><\/h4>\n\n\n\n<p>\u73fe\u5728\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u611f\u67d3\u75c7\u30ea\u30b9\u30af\u8a55\u4fa1\u304c\u9032\u3081\u3089\u308c\u3066\u304a\u308a\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u75be\u60a3\u306e\u30ea\u30b9\u30af\u4e88\u6e2c\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7d50\u6838\uff08TB\uff09<\/strong>\uff1aIFNG\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u5909\u7570\u304c\u7d50\u6838\u611f\u67d3\u306e\u611f\u53d7\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30c7\u30f3\u30b0\u71b1<\/strong>\uff1a\u7279\u5b9a\u306eHLA\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u304c\u3001\u30c7\u30f3\u30b0\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u5f8c\u306e\u75c7\u72b6\u306e\u91cd\u3055\u306b\u95a2\u9023\u3002<\/li>\n<\/ul>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \u514d\u75ab\u7cfb\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u533b\u7642<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3-1. \u907a\u4f1d\u5b50\u306b\u57fa\u3065\u304f\u30ef\u30af\u30c1\u30f3\u306e\u958b\u767a<\/strong><\/h4>\n\n\n\n<p>\u500b\u3005\u306e\u907a\u4f1d\u5b50\u306b\u5fdc\u3058\u305f\u30ef\u30af\u30c1\u30f3\u306e\u6700\u9069\u5316\u304c\u9032\u3081\u3089\u308c\u3066\u304a\u308a\u3001<strong>\u907a\u4f1d\u7684\u8981\u56e0\u3092\u8003\u616e\u3057\u305f\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u30d7\u30ed\u30b0\u30e9\u30e0<\/strong>\u304c\u5c06\u6765\u7684\u306b\u5b9f\u73fe\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u304c\u3093\u30ef\u30af\u30c1\u30f3\u306e\u958b\u767a<\/strong><strong><br><\/strong>\u907a\u4f1d\u5b50\u89e3\u6790\u3092\u6d3b\u7528\u3057\u3001\u500b\u3005\u306e\u816b\u760d\u306e\u7279\u7570\u7684\u306a\u5909\u7570\u306b\u5fdc\u3058\u305f**\u300c\u30cd\u30aa\u30a2\u30f3\u30c1\u30b2\u30f3\u30ef\u30af\u30c1\u30f3\u300d**\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\uff1aCancer Immunology Research\uff09\u3002<\/li>\n\n\n\n<li><strong>\u500b\u5225\u5316\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30ef\u30af\u30c1\u30f3<\/strong><strong><br><\/strong>HLA\u30bf\u30a4\u30d7\u306b\u57fa\u3065\u304d\u3001\u6700\u9069\u306a\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30ef\u30af\u30c1\u30f3\u3092\u8a2d\u8a08\u3059\u308b\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3-2. \u514d\u75ab\u7642\u6cd5\u3068\u907a\u4f1d\u5b50\u8a3a\u65ad<\/strong><\/h4>\n\n\n\n<p>\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\uff08\u30aa\u30d7\u30b8\u30fc\u30dc\u306a\u3069\uff09\u306f\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u6cbb\u7642\u52b9\u679c\u3092\u4e88\u6e2c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PD-L1\u767a\u73fe\u3068\u304c\u3093\u6cbb\u7642<\/strong><strong><br><\/strong>PD-L1\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u91cf\u306b\u5fdc\u3058\u3066\u3001\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u304c\u6709\u52b9\u304b\u3069\u3046\u304b\u3092\u5224\u65ad\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\uff08\u53c2\u8003\uff1aJournal of Clinical Oncology\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4. \u907a\u4f1d\u5b50\u3092\u6d3b\u7528\u3057\u305f\u672a\u6765\u306e\u514d\u75ab\u533b\u7642<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/4629216_m-1024x683.jpg\" alt=\"\u713c\u304d\u9b5a\u306e\u98df\u5353\" class=\"wp-image-3319\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4629216_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4629216_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4629216_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4629216_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4629216_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>4-1. CRISPR\u6280\u8853\u306b\u3088\u308b\u514d\u75ab\u7cfb\u306e\u6539\u5909<\/strong><\/h4>\n\n\n\n<p>CRISPR-Cas9\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306b\u3088\u308a\u3001<strong>\u514d\u75ab\u7cfb\u3092\u5f37\u5316\u3057\u3001\u611f\u67d3\u75c7\u3084\u304c\u3093\u306b\u5bfe\u3059\u308b\u62b5\u6297\u529b\u3092\u9ad8\u3081\u308b\u8a66\u307f<\/strong>\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u7de8\u96c6\u306b\u3088\u308bHIV\u8010\u6027<\/strong><strong><br><\/strong>CCR5\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u4eba\u5de5\u7684\u306b\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u3001HIV\u611f\u67d3\u3092\u9632\u3050\u8a66\u307f\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u304c\u3093\u514d\u75ab\u7642\u6cd5\u306e\u5f37\u5316<\/strong><strong><br><\/strong>\u514d\u75ab\u7d30\u80de\u306e\u907a\u4f1d\u5b50\u3092\u6539\u5909\u3057\u3001\u304c\u3093\u7d30\u80de\u3092\u52b9\u679c\u7684\u306b\u653b\u6483\u3059\u308bCAR-T\u7642\u6cd5\u304c\u3055\u3089\u306b\u9032\u5316\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u8ffd\u52a0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u30ea\u30f3\u30af<\/strong><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Frontiers in Immunology \u2013 HLA\u907a\u4f1d\u5b50\u3068\u30ef\u30af\u30c1\u30f3\u5fdc\u7b54<\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/nmicrobiol\">Nature Microbiology \u2013 FUT2\u907a\u4f1d\u5b50\u3068\u8178\u5185\u7d30\u83cc<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nejm.org\/\">New England Journal of Medicine \u2013 HLA\u907a\u4f1d\u5b50\u3068COVID-19<\/a><\/li>\n\n\n\n<li>Cancer Immunology Research \u2013 \u30cd\u30aa\u30a2\u30f3\u30c1\u30b2\u30f3\u30ef\u30af\u30c1\u30f3<\/li>\n\n\n\n<li>Journal of Clinical Oncology \u2013 PD-L1\u3068\u514d\u75ab\u7642\u6cd5<\/li>\n<\/ol>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u514d\u75ab\u907a\u4f1d\u5b66\u306e\u6700\u524d\u7dda\uff1a\u65b0\u305f\u306a\u767a\u898b\u3068\u5fdc\u7528\u306e\u53ef\u80fd\u6027<\/strong><\/h3>\n\n\n\n<p>\u514d\u75ab\u907a\u4f1d\u5b66\u306e\u7814\u7a76\u304c\u9032\u3080\u306b\u3064\u308c\u3001\u514d\u75ab\u7cfb\u306e\u500b\u4eba\u5dee\u304c\u3069\u306e\u3088\u3046\u306b\u75c5\u6c17\u306e\u767a\u75c7\u3084\u6cbb\u7642\u53cd\u5fdc\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u306e\u304b\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002<strong>\u6700\u65b0\u306e\u7814\u7a76\u6210\u679c\u306f\u3001\u611f\u67d3\u75c7\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u3001\u304c\u3093\u514d\u75ab\u6cbb\u7642\u306a\u3069\u306e\u5206\u91ce\u3067\u6d3b\u7528\u3055\u308c\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u3063\u3066\u3044\u307e\u3059<\/strong>\u3002\u3053\u3053\u3067\u306f\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u6700\u65b0\u306e\u514d\u75ab\u7814\u7a76\u3068\u3001\u305d\u306e\u5fdc\u7528\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1-1. \u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h4>\n\n\n\n<p>\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306f\u3001\u514d\u75ab\u7cfb\u304c\u81ea\u5df1\u306e\u7d30\u80de\u3084\u7d44\u7e54\u3092\u8aa4\u3063\u3066\u653b\u6483\u3059\u308b\u3053\u3068\u3067\u767a\u75c7\u3057\u307e\u3059\u3002\u3053\u306e\u7570\u5e38\u306a\u514d\u75ab\u5fdc\u7b54\u306b\u306f\u3001<strong>HLA\u907a\u4f1d\u5b50\u3084\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u591a\u578b\u304c\u95a2\u4e0e<\/strong>\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>HLA-DR4\u3068\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1<\/strong><strong><br><\/strong>HLA-DR4\u907a\u4f1d\u5b50\u3092\u6301\u3064\u4eba\u306f\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u30ea\u30b9\u30af\u304c\u7d043\uff5e4\u500d\u9ad8\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u308a\u3001\u81ea\u5df1\u514d\u75ab\u53cd\u5fdc\u304c\u904e\u5270\u306b\u306a\u308a\u3001\u95a2\u7bc0\u7d44\u7e54\u3078\u306e\u708e\u75c7\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/onlinelibrary.wiley.com\/journal\/23265205\">\u53c2\u8003\uff1aArthritis &amp; Rheumatology<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>IL23R\u907a\u4f1d\u5b50\u3068\u708e\u75c7\u6027\u8178\u75be\u60a3<\/strong><strong><br><\/strong>IL23R\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u30af\u30ed\u30fc\u30f3\u75c5\u3084\u6f70\u760d\u6027\u5927\u8178\u708e\u3068\u3044\u3063\u305f\u708e\u75c7\u6027\u8178\u75be\u60a3\uff08IBD\uff09\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306f\u3001<strong>\u8178\u5185\u306e\u514d\u75ab\u5fdc\u7b54\u3092\u8abf\u6574\u3059\u308b\u5f79\u5272\u3092\u6301\u3061\u3001\u904e\u5270\u306a\u514d\u75ab\u53cd\u5fdc\u304c\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059<\/strong>\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.gastrojournal.org\/\">\u53c2\u8003\uff1aGastroenterology<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>PTPN22\u907a\u4f1d\u5b50\u30681\u578b\u7cd6\u5c3f\u75c5<\/strong><strong><br><\/strong>PTPN22\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u30011\u578b\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306f\u514d\u75ab\u7d30\u80de\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u95a2\u4e0e\u3057\u3001\u5909\u7570\u306b\u3088\u3063\u3066\u514d\u75ab\u7cfb\u306e\u81ea\u5df1\u653b\u6483\u304c\u4fc3\u9032\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1-2. \u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308b\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u4e88\u6e2c\u3068\u6cbb\u7642<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3057\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u6cbb\u7642\u30d7\u30e9\u30f3\u3092\u63d0\u6848\u3059\u308b<\/strong>\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>HLA\u907a\u4f1d\u5b50\u691c\u67fb\u3068\u30ea\u30b9\u30af\u8a55\u4fa1<\/strong><strong><br><\/strong>\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\uff08\u5c0f\u9ea6\u30b0\u30eb\u30c6\u30f3\u306b\u5bfe\u3059\u308b\u81ea\u5df1\u514d\u75ab\u75be\u60a3\uff09\u3067\u306f\u3001HLA-DQ2\u307e\u305f\u306fHLA-DQ8\u3092\u6301\u3064\u4eba\u304c\u767a\u75c7\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u60c5\u5831\u3092\u57fa\u306b\u3001<strong>\u65e9\u671f\u306e\u98df\u4e8b\u7ba1\u7406\u3084\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u304c\u53ef\u80fd<\/strong>\u306b\u306a\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u6d3b\u7528\u3057\u305f\u6cbb\u7642\u6cd5\u306e\u6700\u9069\u5316<\/strong><strong><br><\/strong>\u907a\u4f1d\u5b50\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u3092\u5229\u7528\u3057\u3066\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u6cbb\u7642\u306b\u304a\u3051\u308b<strong>TNF\u963b\u5bb3\u5264\uff08\u30a4\u30f3\u30d5\u30ea\u30ad\u30b7\u30de\u30d6\u306a\u3069\uff09\u306e\u52b9\u679c\u3092\u4e88\u6e2c<\/strong>\u3059\u308b\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u60a3\u8005\u306f\u3001\u5225\u306e\u6cbb\u7642\u6cd5\u306e\u307b\u3046\u304c\u52b9\u679c\u7684\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u30a2\u30ec\u30eb\u30ae\u30fc\u3068\u514d\u75ab\u907a\u4f1d\u5b66<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"768\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/24145813_m-1024x768.jpg\" alt=\"\u304f\u3057\u3083\u307f\u3000\u7537\u6027\" class=\"wp-image-2872\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/24145813_m-1024x768.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/24145813_m-300x225.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/24145813_m-768x576.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/24145813_m-1536x1152.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/24145813_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2-1. \u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3068\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<p>\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\uff08\u82b1\u7c89\u75c7\u3001\u5598\u606f\u3001\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306a\u3069\uff09\u306f\u3001\u74b0\u5883\u8981\u56e0\u3068\u907a\u4f1d\u7684\u8981\u56e0\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u767a\u75c7\u3057\u307e\u3059\u3002\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001<strong>\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u30a2\u30ec\u30eb\u30ae\u30fc\u4f53\u8cea\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b<\/strong>\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IL4R\u907a\u4f1d\u5b50\u3068\u5598\u606f<\/strong><strong><br><\/strong>IL4R\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u5598\u606f\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u8981\u56e0\u3068\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306f\u3001IgE\u6297\u4f53\uff08\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3059\u6297\u4f53\uff09\u306e\u7523\u751f\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.jacionline.org\/\">\u53c2\u8003\uff1aJournal of Allergy and Clinical Immunology<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>FLG\u907a\u4f1d\u5b50\u3068\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e<\/strong><strong><br><\/strong>FLG\uff08\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\uff09\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u76ae\u819a\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u304c\u5909\u7570\u3059\u308b\u3068\u3001<strong>\u76ae\u819a\u306e\u4fdd\u6e7f\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u30a2\u30ec\u30eb\u30b2\u30f3\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u304c\u5897\u52a0<\/strong>\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>HLA\u907a\u4f1d\u5b50\u3068\u82b1\u7c89\u75c7<\/strong><strong><br><\/strong>\u7279\u5b9a\u306eHLA\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u30b9\u30ae\u82b1\u7c89\u3084\u30c0\u30cb\u30a2\u30ec\u30eb\u30ae\u30fc\u306b\u5bfe\u3059\u308b\u904e\u5270\u306a\u514d\u75ab\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3057\u3084\u3059\u304f\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2-2. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001<strong>\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3057\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u6cbb\u7642\u6cd5\u3092\u9078\u629e\u3059\u308b<\/strong>\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u514d\u75ab\u7642\u6cd5\u306e\u6700\u9069\u5316<\/strong><strong><br><\/strong>\u30a2\u30ec\u30eb\u30b2\u30f3\u514d\u75ab\u7642\u6cd5\uff08\u6e1b\u611f\u4f5c\u7642\u6cd5\uff09\u306e\u52b9\u679c\u306f\u3001HLA\u907a\u4f1d\u5b50\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u884c\u3046\u3053\u3068\u3067\u3001<strong>\u6cbb\u7642\u306e\u6210\u529f\u7387\u3092\u4e8b\u524d\u306b\u8a55\u4fa1\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd<\/strong>\u306b\u306a\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u500b\u5225\u5316\u6804\u990a\u7642\u6cd5<\/strong><strong><br><\/strong>\u907a\u4f1d\u60c5\u5831\u3092\u57fa\u306b\u3001\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u6301\u3064\u4eba\u306b\u6700\u9069\u306a\u98df\u4e8b\u30d7\u30e9\u30f3\u3092\u63d0\u6848\u3059\u308b\u300c\u30cb\u30e5\u30fc\u30c8\u30ea\u30b2\u30ce\u30df\u30af\u30b9\u300d\u304c\u767a\u5c55\u3057\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u30ca\u30c3\u30c4\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba\u306b\u306f\u3001\u7279\u5b9a\u306e\u98df\u54c1\u3092\u907f\u3051\u308b\u98df\u4e8b\u6307\u5c0e\u304c\u884c\u308f\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-2887cae1-7fff-c98b-c0c9-daf40835560e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \u514d\u75ab\u907a\u4f1d\u5b66\u306e\u672a\u6765<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3-1. \u907a\u4f1d\u5b50\u7de8\u96c6\u306b\u3088\u308b\u514d\u75ab\u5f37\u5316<\/strong><\/h4>\n\n\n\n<p>CRISPR\u6280\u8853\u3092\u6d3b\u7528\u3057\u305f\u514d\u75ab\u7cfb\u306e\u5f37\u5316\u304c\u7814\u7a76\u3055\u308c\u3066\u304a\u308a\u3001\u5c06\u6765\u7684\u306b\u306f<strong>\u907a\u4f1d\u5b50\u3092\u6539\u5909\u3059\u308b\u3053\u3068\u3067\u3001\u7279\u5b9a\u306e\u75c5\u6c17\u306b\u5bfe\u3059\u308b\u514d\u75ab\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u53ef\u80fd<\/strong>\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>HIV\u8010\u6027\u306e\u4ed8\u4e0e<\/strong><strong><br><\/strong>CCR5\u907a\u4f1d\u5b50\u3092\u7de8\u96c6\u3057\u3001HIV\u304c\u7d30\u80de\u306b\u4fb5\u5165\u3067\u304d\u306a\u3044\u3088\u3046\u306b\u3059\u308b\u8a66\u307f\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u304c\u3093\u514d\u75ab\u7d30\u80de\u306e\u6539\u5909<\/strong><strong><br><\/strong>\u514d\u75ab\u7d30\u80de\u3092\u907a\u4f1d\u5b50\u7de8\u96c6\u3059\u308b\u3053\u3068\u3067\u3001\u304c\u3093\u7d30\u80de\u3092\u3088\u308a\u52b9\u679c\u7684\u306b\u653b\u6483\u3059\u308b\u300c\u30b9\u30fc\u30d1\u30fcT\u7d30\u80de\u300d\u306e\u958b\u767a\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3-2. AI\u3068\u907a\u4f1d\u5b50\u60c5\u5831\u306e\u7d71\u5408<\/strong><\/h4>\n\n\n\n<p>AI\u6280\u8853\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u89e3\u6790\u304c\u9032\u307f\u3001<strong>\u500b\u3005\u306e\u514d\u75ab\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306b\u57fa\u3065\u3044\u305f\u6cbb\u7642\u6cd5\u304c\u81ea\u52d5\u3067\u63d0\u6848\u3055\u308c\u308b\u672a\u6765<\/strong>\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AI\u306b\u3088\u308b\u75be\u60a3\u30ea\u30b9\u30af\u4e88\u6e2c<\/strong><strong><br><\/strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3068\u533b\u7642\u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u3092\u7d44\u307f\u5408\u308f\u305b\u3001\u75be\u60a3\u30ea\u30b9\u30af\u3092\u9ad8\u7cbe\u5ea6\u3067\u4e88\u6e2c\u3059\u308b\u30e2\u30c7\u30eb\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30ef\u30af\u30c1\u30f3\u306e\u958b\u767a<\/strong><strong><br><\/strong>\u907a\u4f1d\u60c5\u5831\u3092\u57fa\u306b\u3001\u6700\u9069\u306a\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u500b\u5225\u306b\u8a2d\u8a08\u3059\u308b\u53d6\u308a\u7d44\u307f\u304c\u9032\u884c\u4e2d\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u514d\u75ab\u907a\u4f1d\u5b66\u306e\u6700\u65b0\u6280\u8853\u3068\u305d\u306e\u5fdc\u7528<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/29916613_m-1024x683.jpg\" alt=\"AI\" class=\"wp-image-1752\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/29916613_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/29916613_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/29916613_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/29916613_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/29916613_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u514d\u75ab\u907a\u4f1d\u5b66\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u75c5\u6c17\u306e\u767a\u75c7\u30ea\u30b9\u30af\u8a55\u4fa1\u3084\u6cbb\u7642\u65b9\u6cd5\u306e\u6700\u9069\u5316\u304c\u52a0\u901f\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001<strong>\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u306e\u5411\u4e0a\u3001AI\u306b\u3088\u308b\u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u89e3\u6790\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u9032\u5c55<\/strong>\u306b\u3088\u3063\u3066\u3001\u514d\u75ab\u7cfb\u306e\u500b\u4eba\u5dee\u306b\u57fa\u3065\u304f\u9769\u65b0\u7684\u306a\u6cbb\u7642\u304c\u5b9f\u73fe\u3057\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u3053\u3053\u3067\u306f\u3001\u6700\u65b0\u306e\u6280\u8853\u3068\u305d\u306e\u5fdc\u7528\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u514d\u75ab\u907a\u4f1d\u5b66\u3068\u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u89e3\u6790<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1-1. AI\u306b\u3088\u308b\u514d\u75ab\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0<\/strong><\/h4>\n\n\n\n<p>\u8fd1\u5e74\u3001\u4eba\u5de5\u77e5\u80fd\uff08AI\uff09\u3092\u6d3b\u7528\u3057\u305f\u514d\u75ab\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u6280\u8853\u304c\u9032\u5316\u3057\u3001\u500b\u3005\u306e\u514d\u75ab\u5fdc\u7b54\u3092\u9ad8\u7cbe\u5ea6\u3067\u5206\u6790\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6a5f\u68b0\u5b66\u7fd2\u306b\u3088\u308b\u75be\u60a3\u30ea\u30b9\u30af\u4e88\u6e2c<\/strong><strong><br><\/strong>\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3001\u8840\u6db2\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3001\u533b\u7642\u5c65\u6b74\u3092AI\u3067\u7d71\u5408\u89e3\u6790\u3057\u3001<strong>\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3084\u611f\u67d3\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3059\u308b\u6280\u8853<\/strong>\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u4e8b\u524d\u306b\u4e88\u9632\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/natmachintell\/\">\u53c2\u8003\uff1aNature Machine Intelligence<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>\u500b\u5225\u5316\u30ef\u30af\u30c1\u30f3\u306e\u958b\u767a<\/strong><strong><br><\/strong>AI\u3092\u6d3b\u7528\u3057\u305f\u514d\u75ab\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u306b\u3088\u308a\u3001<strong>\u7279\u5b9a\u306eHLA\u30bf\u30a4\u30d7\u306b\u6700\u9069\u306a\u30ef\u30af\u30c1\u30f3\u8a2d\u8a08<\/strong>\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30ef\u30af\u30c1\u30f3\u306e\u52b9\u679c\u3092\u6700\u5927\u5316\u3057\u3001\u526f\u4f5c\u7528\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1-2. \u30de\u30eb\u30c1\u30aa\u30df\u30af\u30b9\u89e3\u6790\u306b\u3088\u308b\u500b\u5225\u5316\u6cbb\u7642<\/strong><\/h4>\n\n\n\n<p>\u300c\u30de\u30eb\u30c1\u30aa\u30df\u30af\u30b9\u89e3\u6790\u300d\u3068\u306f\u3001<strong>\u30b2\u30ce\u30e0\uff08DNA\uff09\u3001\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\uff08RNA\uff09\u3001\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\uff08\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u3001\u30e1\u30bf\u30dc\u30ed\u30fc\u30e0\uff08\u4ee3\u8b1d\u7523\u7269\uff09\u306a\u3069\u3092\u7d71\u5408\u89e3\u6790\u3059\u308b\u624b\u6cd5<\/strong>\u3067\u3059\u3002\u3053\u308c\u3092\u514d\u75ab\u7814\u7a76\u306b\u5fdc\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u7cbe\u5bc6\u306a\u500b\u5225\u5316\u533b\u7642\u304c\u5b9f\u73fe\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u304c\u3093\u514d\u75ab\u7642\u6cd5\u306e\u500b\u5225\u5316<\/strong><strong><br><\/strong>\u304c\u3093\u60a3\u8005\u306e\u816b\u760d\u7d30\u80de\u3068\u514d\u75ab\u7d30\u80de\u306e\u907a\u4f1d\u5b50\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u89e3\u6790\u3057\u3001<strong>\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\uff08\u30aa\u30d7\u30b8\u30fc\u30dc\u306a\u3069\uff09\u304c\u6709\u52b9\u304b\u3069\u3046\u304b\u3092\u4e8b\u524d\u306b\u4e88\u6e2c<\/strong>\u3059\u308b\u6280\u8853\u304c\u9032\u5316\u3057\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\uff1aCell Reports Medicine\uff09\u3002<\/li>\n\n\n\n<li><strong>\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u6cbb\u7642\u9078\u629e<\/strong><strong><br><\/strong>\u30de\u30eb\u30c1\u30aa\u30df\u30af\u30b9\u89e3\u6790\u306b\u3088\u308a\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u60a3\u8005\u3054\u3068\u306b\u6700\u9069\u306a\u6cbb\u7642\u85ac\u3092\u9078\u629e\u3059\u308b\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001<strong>\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u60a3\u8005\u306b\u5bfe\u3057\u3001TNF\u963b\u5bb3\u5264\u3084IL-6\u963b\u5bb3\u5264\u306e\u3069\u3061\u3089\u304c\u9069\u3057\u3066\u3044\u308b\u304b\u3092\u907a\u4f1d\u5b50\u60c5\u5831\u304b\u3089\u5224\u65ad\u3059\u308b<\/strong>\u624b\u6cd5\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3092\u6d3b\u7528\u3057\u305f\u514d\u75ab\u6cbb\u7642<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2-1. CRISPR-Cas9\u306b\u3088\u308b\u514d\u75ab\u7d30\u80de\u306e\u5f37\u5316<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u300cCRISPR-Cas9\u300d\u3092\u7528\u3044\u305f\u514d\u75ab\u7cfb\u306e\u6539\u5909\u304c\u3001\u304c\u3093\u6cbb\u7642\u3084\u611f\u67d3\u75c7\u5bfe\u7b56\u306b\u5fdc\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>HIV\u8010\u6027\u306e\u7372\u5f97<\/strong><strong><br><\/strong>CRISPR\u6280\u8853\u3092\u7528\u3044\u3066CCR5\u907a\u4f1d\u5b50\u3092\u6539\u5909\u3057\u3001<strong>HIV\u304c\u7d30\u80de\u306b\u4fb5\u5165\u3067\u304d\u306a\u3044\u8010\u6027\u3092\u6301\u305f\u305b\u308b<\/strong>\u6cbb\u7642\u304c\u81e8\u5e8a\u8a66\u9a13\u3067\u691c\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nejm.org\/\">\u53c2\u8003\uff1aNew England Journal of Medicine<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>\u304c\u3093\u514d\u75ab\u7d30\u80de\u306e\u6539\u5909\uff08\u30b9\u30fc\u30d1\u30fcT\u7d30\u80de\uff09<\/strong><strong><br><\/strong>\u514d\u75ab\u7d30\u80de\uff08T\u7d30\u80de\uff09\u306e\u907a\u4f1d\u5b50\u3092\u7de8\u96c6\u3057\u3001<strong>\u304c\u3093\u7d30\u80de\u3092\u3088\u308a\u52b9\u679c\u7684\u306b\u653b\u6483\u3059\u308b\u300c\u30b9\u30fc\u30d1\u30fcT\u7d30\u80de\u300d\u3092\u4f5c\u88fd\u3059\u308b\u6280\u8853<\/strong>\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u304c\u3093\u514d\u75ab\u7642\u6cd5\u306e\u6210\u529f\u7387\u304c\u5411\u4e0a\u3059\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2-2. \u907a\u4f1d\u5b50\u7de8\u96c6\u30ef\u30af\u30c1\u30f3\u306e\u958b\u767a<\/strong><\/h4>\n\n\n\n<p>mRNA\u30ef\u30af\u30c1\u30f3\u306e\u6280\u8853\u9769\u65b0\u306b\u3088\u308a\u3001<strong>\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u3092\u7de8\u96c6\u3057\u305f\u30ef\u30af\u30c1\u30f3<\/strong>\u304c\u958b\u767a\u3055\u308c\u3001\u611f\u67d3\u75c7\u306e\u4e88\u9632\u3084\u304c\u3093\u6cbb\u7642\u306b\u5fdc\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u500b\u5225\u5316\u304c\u3093\u30ef\u30af\u30c1\u30f3<\/strong><strong><br><\/strong>\u60a3\u8005\u306e\u816b\u760d\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u89e3\u6790\u3057\u3001\u305d\u308c\u306b\u57fa\u3065\u3044\u3066mRNA\u30ef\u30af\u30c1\u30f3\u3092\u8a2d\u8a08\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u500b\u5225\u5316\u304c\u3093\u514d\u75ab\u7642\u6cd5\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059<\/strong>\uff08\u53c2\u8003\uff1aCancer Immunology Research\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-2887cae1-7fff-c98b-c0c9-daf40835560e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \u514d\u75ab\u907a\u4f1d\u5b66\u306e\u793e\u4f1a\u7684\u5fdc\u7528<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/31376008_m-1024x683.jpg\" alt=\"\u591c\u306e\u6b4c\u821e\u4f0e\u753a\" class=\"wp-image-3326\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31376008_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31376008_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31376008_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31376008_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31376008_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3-1. \u516c\u8846\u885b\u751f\u3078\u306e\u5fdc\u7528<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u3001<strong>\u611f\u67d3\u75c7\u306e\u6d41\u884c\u4e88\u6e2c\u3084\u4e88\u9632\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u8a2d\u8a08<\/strong>\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u5bfe\u7b56\u306e\u6700\u9069\u5316<\/strong><strong><br><\/strong>COVID-19\u306e\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u3067\u306f\u3001HLA\u907a\u4f1d\u5b50\u3084\u8840\u6db2\u578b\u306b\u3088\u308b\u611f\u67d3\u30ea\u30b9\u30af\u306e\u9055\u3044\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\u4eca\u5f8c\u3001<strong>\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u57fa\u306b\u611f\u67d3\u75c7\u5bfe\u7b56\u3092\u500b\u5225\u5316\u3057\u3001\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u4eba\u3005\u306b\u512a\u5148\u7684\u306a\u533b\u7642\u5bfe\u5fdc\u3092\u63d0\u4f9b\u3059\u308b<\/strong>\u53d6\u308a\u7d44\u307f\u304c\u9032\u3080\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u6700\u9069\u5316<\/strong><strong><br><\/strong>\u907a\u4f1d\u5b50\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u57fa\u306b\u3001<strong>\u52b9\u679c\u306e\u9ad8\u3044\u30ef\u30af\u30c1\u30f3\u306e\u7a2e\u985e\u3084\u63a5\u7a2e\u56de\u6570\u3092\u500b\u5225\u306b\u8abf\u6574\u3059\u308b<\/strong>\u6280\u8853\u304c\u767a\u5c55\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3-2. \u4fdd\u967a\u30fb\u533b\u7642\u5236\u5ea6\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<p>\u514d\u75ab\u907a\u4f1d\u5b66\u306e\u9032\u5c55\u306f\u3001\u4fdd\u967a\u3084\u533b\u7642\u5236\u5ea6\u306b\u3082\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u304f\u533b\u7642\u8cbb\u306e\u524a\u6e1b<\/strong><strong><br><\/strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u7121\u99c4\u306a\u85ac\u5264\u6295\u4e0e\u3092\u6e1b\u3089\u3057\u3001\u6700\u9069\u306a\u6cbb\u7642\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u3067\u533b\u7642\u8cbb\u306e\u524a\u6e1b\u304c\u671f\u5f85<\/strong>\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u533b\u7642\u306e\u683c\u5dee\u662f\u6b63<\/strong><strong><br><\/strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u533b\u7642\u304c\u9032\u3080\u4e00\u65b9\u3067\u3001<strong>\u9ad8\u984d\u306a\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u53d7\u3051\u3089\u308c\u308b\u4eba\u3068\u53d7\u3051\u3089\u308c\u306a\u3044\u4eba\u306e\u9593\u3067\u533b\u7642\u683c\u5dee\u304c\u751f\u3058\u308b\u30ea\u30b9\u30af<\/strong>\u3082\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u502b\u7406\u7684\u306a\u8b70\u8ad6\u3068\u3068\u3082\u306b\u3001\u30a2\u30af\u30bb\u30b9\u306e\u516c\u5e73\u6027\u3092\u78ba\u4fdd\u3059\u308b\u4ed5\u7d44\u307f\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u8ffd\u52a0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u30ea\u30f3\u30af<\/strong><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nature.com\/natmachintell\/\">Nature Machine Intelligence \u2013 AI\u3068\u514d\u75ab\u907a\u4f1d\u5b66<\/a><\/li>\n\n\n\n<li>Cell Reports Medicine \u2013 \u30de\u30eb\u30c1\u30aa\u30df\u30af\u30b9\u89e3\u6790\u3068\u500b\u5225\u5316\u533b\u7642<\/li>\n\n\n\n<li><a href=\"https:\/\/www.nejm.org\/\">New England Journal of Medicine \u2013 CRISPR\u3068HIV\u8010\u6027<\/a><\/li>\n\n\n\n<li>Cancer Immunology Research \u2013 \u907a\u4f1d\u5b50\u7de8\u96c6\u30ef\u30af\u30c1\u30f3<\/li>\n<\/ol>\n\n\n\n<p><span id=\"docs-internal-guid-2887cae1-7fff-c98b-c0c9-daf40835560e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u307e\u3068\u3081<\/strong><\/h3>\n\n\n\n<p>\u514d\u75ab\u7cfb\u306e\u50cd\u304d\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u3001\u305d\u306e\u9055\u3044\u306fHLA\u907a\u4f1d\u5b50\u3084\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u95a2\u9023\u907a\u4f1d\u5b50\u306a\u3069\u3001<strong>\u907a\u4f1d\u7684\u8981\u56e0\u304c\u5927\u304d\u304f\u95a2\u4e0e<\/strong>\u3057\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u306b\u3088\u308a\u3001<strong>\u611f\u67d3\u75c7\u306e\u30ea\u30b9\u30af\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u3001\u30ef\u30af\u30c1\u30f3\u5fdc\u7b54\u306e\u9055\u3044<\/strong>\u306a\u3069\u304c\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u89e3\u660e\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u3001CRISPR\u3084AI\u3092\u6d3b\u7528\u3057\u305f\u514d\u75ab\u6cbb\u7642\u306e\u9032\u5316\u306b\u3088\u308a\u3001<strong>\u500b\u5225\u5316\u533b\u7642\u304c\u73fe\u5b9f\u306e\u3082\u306e\u3068\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059<\/strong>\u3002\u4eca\u5f8c\u3082\u907a\u4f1d\u5b50\u3068\u514d\u75ab\u306e\u7814\u7a76\u304c\u9032\u3080\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u3067\u5b89\u5168\u306a\u533b\u7642\u306e\u63d0\u4f9b\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u514d\u75ab\u7cfb\u306f\u79c1\u305f\u3061\u306e\u4f53\u3092\u30a6\u30a4\u30eb\u30b9\u3084\u7d30\u83cc\u306a\u3069\u306e\u5916\u6575\u304b\u3089\u5b88\u308b\u91cd\u8981\u306a\u9632\u5fa1\u6a5f\u69cb\u3067\u3059\u304c\u3001\u305d\u306e\u50cd\u304d\u65b9\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u9055\u3044\u306e\u80cc\u666f\u306b\u306f\u907a\u4f1d\u5b50\u304c\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u7684\u8981\u56e0\u304c\u514d\u75ab\u53cd\u5fdc\u306e\u5f37\u3055\u3084\u75c5\u6c17\u3078\u306e\u62b5\u6297\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u660e [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":1399,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-957","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/957","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=957"}],"version-history":[{"count":3,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/957\/revisions"}],"predecessor-version":[{"id":3333,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/957\/revisions\/3333"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/1399"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=957"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=957"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}