{"id":9672,"date":"2025-03-12T04:01:09","date_gmt":"2025-03-12T04:01:09","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=9672"},"modified":"2025-03-12T04:01:11","modified_gmt":"2025-03-12T04:01:11","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e8%85%b8%e3%81%ae%e5%81%a5%e5%ba%b7%ef%bc%9a%e5%85%8d%e7%96%ab%e5%8a%9b%e3%82%92%e9%ab%98%e3%82%81%e3%82%8b%e6%96%b9%e6%b3%95","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e8%85%b8%e3%81%ae%e5%81%a5%e5%ba%b7%ef%bc%9a%e5%85%8d%e7%96%ab%e5%8a%9b%e3%82%92%e9%ab%98%e3%82%81%e3%82%8b%e6%96%b9%e6%b3%95\/","title":{"rendered":"\u907a\u4f1d\u5b50\u3068\u8178\u306e\u5065\u5eb7\uff1a\u514d\u75ab\u529b\u3092\u9ad8\u3081\u308b\u65b9\u6cd5"},"content":{"rendered":"\n<p>\u8178\u306f\u300c\u7b2c\u4e8c\u306e\u8133\u300d\u3068\u3082\u547c\u3070\u308c\u3001\u6d88\u5316\u3060\u3051\u3067\u306a\u304f\u3001\u514d\u75ab\u6a5f\u80fd\u3084\u7cbe\u795e\u72b6\u614b\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u91cd\u8981\u306a\u81d3\u5668\u3067\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u3084\u8178\u306e\u5065\u5eb7\u304c\u907a\u4f1d\u7684\u8981\u56e0\u3068\u6df1\u304f\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u306f\u8178\u5185\u74b0\u5883\u306e\u5f62\u6210\u306b\u95a2\u4e0e\u3057\u3001\u305d\u308c\u304c\u514d\u75ab\u529b\u306e\u5f37\u5316\u3084\u708e\u75c7\u306e\u6291\u5236\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u907a\u4f1d\u5b50\u3068\u8178\u306e\u5065\u5eb7\u306e\u95a2\u4fc2\u3092\u6398\u308a\u4e0b\u3052\u3001\u514d\u75ab\u529b\u3092\u9ad8\u3081\u308b\u305f\u3081\u306e\u5177\u4f53\u7684\u306a\u65b9\u6cd5\u3092\u79d1\u5b66\u7684\u8996\u70b9\u304b\u3089\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-178f20d7-7fff-68e0-2e27-e3de8c688797\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>1. \u8178\u5185\u7d30\u83cc\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1.1 \u907a\u4f1d\u5b50\u304c\u8178\u5185\u7d30\u83cc\u306e\u69cb\u6210\u3092\u6c7a\u5b9a\u3059\u308b<\/strong><\/h3>\n\n\n\n<p>\u8178\u5185\u306b\u306f\u6570\u767e\u5146\u500b\u306e\u7d30\u83cc\u304c\u751f\u606f\u3057\u3066\u304a\u308a\u3001\u305d\u308c\u3089\u306e\u30d0\u30e9\u30f3\u30b9\u306f**\u300c\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u300d**\u3068\u547c\u3070\u308c\u307e\u3059\u3002\u3053\u306e\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u69cb\u6210\u306b\u306f\u3001\u74b0\u5883\u8981\u56e0\u3060\u3051\u3067\u306a\u304f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3082\u5927\u304d\u304f\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u4e00\u5375\u6027\u53cc\u751f\u5150\u306f\u4e8c\u5375\u6027\u53cc\u751f\u5150\u3088\u308a\u3082\u8178\u5185\u7d30\u83cc\u306e\u7d44\u6210\u304c\u985e\u4f3c\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001<strong>\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u7d0430\u301c40\uff05\u306f\u907a\u4f1d\u7684\u306b\u6c7a\u5b9a\u3055\u308c\u308b<\/strong>\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/nature11209\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3059\u308b\u4ee3\u8868\u7684\u306a\u8178\u5185\u7d30\u83cc\u306e\u4f8b\u3068\u3057\u3066\u3001<strong>Bifidobacterium\uff08\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\uff09<\/strong> \u3084 <strong>Lactobacillus\uff08\u30e9\u30af\u30c8\u30d0\u30c1\u30eb\u30b9\uff09<\/strong> \u306a\u3069\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7d30\u83cc\u306f\u3001\u8178\u5185\u306e\u708e\u75c7\u3092\u6291\u3048\u3001\u514d\u75ab\u7cfb\u3092\u5f37\u5316\u3059\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u4e00\u90e8\u306e\u4eba\u306f\u3001\u3053\u308c\u3089\u306e\u5584\u7389\u83cc\u3092\u751f\u307e\u308c\u3064\u304d\u591a\u304f\u6301\u3061\u3001\u514d\u75ab\u529b\u304c\u9ad8\u3044\u50be\u5411\u306b\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-178f20d7-7fff-68e0-2e27-e3de8c688797\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1.2 FUT2\u907a\u4f1d\u5b50\u3068\u8178\u5185\u7d30\u83cc\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p><strong>FUT2\uff08\u30d5\u30b3\u30b7\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc2\uff09<\/strong> \u907a\u4f1d\u5b50\u306f\u3001\u8178\u5185\u7d30\u83cc\u306e\u5b9a\u7740\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u7279\u306b\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\u306e\u5897\u6b96\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002FUT2\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\u306e\u6570\u304c\u6e1b\u5c11\u3057\u3001\u8178\u306e\u708e\u75c7\u304c\u8d77\u3053\u308a\u3084\u3059\u304f\u306a\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3830831\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001FUT2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba\u306f\u3001\u7279\u5b9a\u306e\u98df\u7269\u7e4a\u7dad\u3092\u3046\u307e\u304f\u6d88\u5316\u3067\u304d\u306a\u3044\u3053\u3068\u304c\u3042\u308a\u3001\u8178\u5185\u74b0\u5883\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u500b\u5225\u306e\u98df\u4e8b\u6226\u7565\u304c\u5fc5\u8981\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-178f20d7-7fff-68e0-2e27-e3de8c688797\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. \u514d\u75ab\u529b\u3092\u9ad8\u3081\u308b\u8178\u3068\u907a\u4f1d\u5b50\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2.1 \u514d\u75ab\u7cfb\u3092\u5236\u5fa1\u3059\u308b\u8178\u5185\u7d30\u83cc\u3068\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u8178\u306f\u3001\u4f53\u5168\u4f53\u306e<strong>\u7d0470\uff05\u306e\u514d\u75ab\u7d30\u80de\u304c\u5b58\u5728\u3059\u308b<\/strong>\u91cd\u8981\u306a\u514d\u75ab\u5668\u5b98\u3067\u3059\u3002\u8178\u5185\u7d30\u83cc\u306f\u3001\u514d\u75ab\u7cfb\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u306a\u304c\u3089\u3001\u75c5\u539f\u4f53\u3092\u9632\u5fa1\u3059\u308b\u50cd\u304d\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001<strong>TLR\uff08\u30c8\u30eb\u69d8\u53d7\u5bb9\u4f53\uff09<\/strong> \u3068\u547c\u3070\u308c\u308b\u907a\u4f1d\u5b50\u7fa4\u306f\u3001\u8178\u5185\u7d30\u83cc\u3068\u514d\u75ab\u7d30\u80de\u306e\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u3092\u5236\u5fa1\u3057\u3001\u9069\u5207\u306a\u514d\u75ab\u5fdc\u7b54\u3092\u8abf\u6574\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7139436\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>NOD2\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u8178\u5185\u7d30\u83cc\u306e\u7570\u5e38\u3092\u611f\u77e5\u3057\u3001\u708e\u75c7\u3092\u6291\u3048\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u30af\u30ed\u30fc\u30f3\u75c5\u306a\u3069\u306e\u8178\u306e\u708e\u75c7\u6027\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/nature03313\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-178f20d7-7fff-68e0-2e27-e3de8c688797\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2.2 \u8178\u5185\u74b0\u5883\u3092\u6539\u5584\u3059\u308b\u6804\u990a\u7d20\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"681\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/22271584_m-1024x681.jpg\" alt=\"\n\u304d\u306e\u3053\u3000\u304d\u306e\u3053\u76db\u308a\u5408\u308f\u305b\" class=\"wp-image-9680\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22271584_m-1024x681.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22271584_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22271584_m-768x511.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22271584_m-1536x1022.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22271584_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u6574\u3048\u3001\u514d\u75ab\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u305f\u3081\u306b\u3001\u7279\u5b9a\u306e\u6804\u990a\u7d20\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u5584\u7389\u83cc\uff09<\/strong>\uff1a\u4e73\u9178\u83cc\u3001\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc<\/li>\n\n\n\n<li><strong>\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u5584\u7389\u83cc\u306e\u30a8\u30b5\uff09<\/strong>\uff1a\u30aa\u30ea\u30b4\u7cd6\u3001\u98df\u7269\u7e4a\u7dad<\/li>\n\n\n\n<li><strong>\u77ed\u9396\u8102\u80aa\u9178\uff08SCFA\uff09<\/strong>\uff1a\u8178\u5185\u7d30\u83cc\u304c\u767a\u9175\u306b\u3088\u308a\u751f\u6210\u3057\u3001\u708e\u75c7\u3092\u6291\u5236<\/li>\n<\/ul>\n\n\n\n<p>\u7279\u306b\u3001SCFA\u306e\u751f\u6210\u306b\u306f <strong>SCFA\u5408\u6210\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\uff08FFAR2, FFAR3\uff09<\/strong> \u304c\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u708e\u75c7\u3092\u6291\u3048\u305f\u308a\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u8abf\u6574\u3059\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/nature07519\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-178f20d7-7fff-68e0-2e27-e3de8c688797\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u907a\u4f1d\u5b50\u3092\u6d3b\u304b\u3057\u305f\u8178\u306e\u5065\u5eb7\u6539\u5584\u65b9\u6cd5<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3.1 \u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u98df\u4e8b\u6226\u7565<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u81ea\u5206\u306e\u8178\u5185\u7d30\u83cc\u306e\u7279\u6027\u3084\u514d\u75ab\u529b\u306e\u5f31\u70b9\u3092\u77e5\u308a\u3001\u6700\u9069\u306a\u98df\u751f\u6d3b\u3092\u5b9f\u8df5\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001<strong>FUT2\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u306f\u3001\u767a\u9175\u98df\u54c1\uff08\u30e8\u30fc\u30b0\u30eb\u30c8\u3001\u30ad\u30e0\u30c1\u3001\u7d0d\u8c46\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\u306e\u5897\u6b96\u3092\u4fc3\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>NOD2\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u306f\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff08\u9b5a\u3001\u30a2\u30de\u30cb\u6cb9\uff09\u3092\u591a\u304f\u542b\u3080\u98df\u4e8b\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u3001\u8178\u306e\u708e\u75c7\u30ea\u30b9\u30af\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-178f20d7-7fff-68e0-2e27-e3de8c688797\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3.2 \u751f\u6d3b\u7fd2\u6163\u306e\u6700\u9069\u5316<\/strong><\/h3>\n\n\n\n<p>\u8178\u5185\u74b0\u5883\u3092\u6574\u3048\u308b\u305f\u3081\u306b\u306f\u3001\u98df\u4e8b\u3060\u3051\u3067\u306a\u304f\u3001\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u6539\u5584\u3082\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406<\/strong>\uff1a\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u304c\u8178\u5185\u7d30\u83cc\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b<\/li>\n\n\n\n<li><strong>\u9069\u5ea6\u306a\u904b\u52d5<\/strong>\uff1a\u904b\u52d5\u306f\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027\u3092\u5411\u4e0a\u3055\u305b\u308b<\/li>\n\n\n\n<li><strong>\u7761\u7720\u306e\u8cea\u306e\u5411\u4e0a<\/strong>\uff1a\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u5b89\u5b9a\u3055\u305b\u308b<\/li>\n<\/ul>\n\n\n\n<p>\u7279\u306b\u3001\u7761\u7720\u3068\u8178\u5185\u74b0\u5883\u306e\u95a2\u9023\u6027\u306b\u3064\u3044\u3066\u306f\u3001<strong>CLOCK\u907a\u4f1d\u5b50<\/strong> \u304c\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u907a\u4f1d\u7684\u306b\u4f53\u5185\u6642\u8a08\u304c\u4e71\u308c\u3084\u3059\u3044\u4eba\u306f\u3001\u8178\u5185\u74b0\u5883\u3082\u4e0d\u5b89\u5b9a\u306b\u306a\u308a\u3084\u3059\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(14)00884-5\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u907a\u4f1d\u5b50\u304c\u8178\u5185\u7d30\u83cc\u3068\u514d\u75ab\u529b\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306f\u975e\u5e38\u306b\u5927\u304d\u304f\u3001\u500b\u3005\u306e\u907a\u4f1d\u7684\u7279\u6027\u3092\u7406\u89e3\u3057\u3001\u305d\u308c\u306b\u57fa\u3065\u3044\u305f\u98df\u751f\u6d3b\u3084\u751f\u6d3b\u7fd2\u6163\u3092\u5b9f\u8df5\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u5065\u5eb7\u7684\u306a\u8178\u3068\u5f37\u3044\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u3001\u81ea\u5206\u306b\u5408\u3063\u305f\u65b9\u6cd5\u3067\u8178\u306e\u5065\u5eb7\u3092\u6700\u9069\u5316\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-178f20d7-7fff-68e0-2e27-e3de8c688797\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>4. \u8178\u5185\u74b0\u5883\u3068\u514d\u75ab\u529b\u3092\u9ad8\u3081\u308b\u5177\u4f53\u7684\u306a\u65b9\u6cd5<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31854106_m-1024x683.jpg\" alt=\"1\u672c\u6307\u3092\u7acb\u3066\u308b\u7537\u6027\u306e\u533b\u8005\" class=\"wp-image-8385\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31854106_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31854106_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31854106_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31854106_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31854106_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4.1 \u8178\u5185\u7d30\u83cc\u3068\u907a\u4f1d\u5b50\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u308b\u514d\u75ab\u8abf\u7bc0<\/strong><\/h3>\n\n\n\n<p>\u8178\u5185\u7d30\u83cc\u3068\u514d\u75ab\u7cfb\u306f\u5bc6\u63a5\u306b\u9023\u643a\u3057\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u7d30\u83cc\u304c\u514d\u75ab\u7d30\u80de\u306e\u6d3b\u52d5\u3092\u8abf\u6574\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001<strong>Faecalibacterium prausnitzii\uff08\u30d5\u30a7\u30fc\u30ab\u30ea\u30d0\u30af\u30c6\u30ea\u30a6\u30e0\u30fb\u30d7\u30e9\u30a6\u30b9\u30cb\u30c3\u30c4\u30a3\uff09<\/strong> \u3068\u3044\u3046\u7d30\u83cc\u306f\u3001\u77ed\u9396\u8102\u80aa\u9178\uff08SCFA\uff09\u3092\u751f\u6210\u3057\u3001\u708e\u75c7\u3092\u6291\u5236\u3059\u308b\u50cd\u304d\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7d30\u83cc\u306e\u5b58\u5728\u306f\u3001\u907a\u4f1d\u7684\u306a\u8981\u56e0\u306b\u3088\u3063\u3066\u5de6\u53f3\u3055\u308c\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41575-019-0191-6\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>Akkermansia muciniphila\uff08\u30a2\u30c3\u30ab\u30fc\u30de\u30f3\u30b7\u30a2\u30fb\u30e0\u30b7\u30cb\u30d5\u30a3\u30e9\uff09<\/strong> \u306f\u3001\u8178\u306e\u7c98\u819c\u3092\u4fdd\u8b77\u3057\u3001\u514d\u75ab\u30d0\u30e9\u30f3\u30b9\u3092\u7dad\u6301\u3059\u308b\u50cd\u304d\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u7d30\u83cc\u306f\u3001<strong>PPAR-\u03b3\u907a\u4f1d\u5b50<\/strong> \u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3057\u3001\u708e\u75c7\u3092\u6291\u3048\u308b\u3053\u3068\u3067\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/gut.bmj.com\/content\/67\/4\/698\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002PPAR-\u03b3\u907a\u4f1d\u5b50\u306f\u8102\u8cea\u4ee3\u8b1d\u3084\u514d\u75ab\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u8178\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u304f\u306a\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u8178\u5185\u7d30\u83cc\u306e\u7a2e\u985e\u3068\u305d\u308c\u3092\u652f\u3048\u308b\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u514d\u75ab\u529b\u5411\u4e0a\u7b56\u3092\u7acb\u3066\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-178f20d7-7fff-68e0-2e27-e3de8c688797\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4.2 \u8178\u5185\u74b0\u5883\u3092\u6574\u3048\u308b\u98df\u54c1\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u9069\u5207\u306a\u98df\u54c1\u306e\u6442\u53d6\u304c\u6b20\u304b\u305b\u307e\u305b\u3093\u3002\u4ee5\u4e0b\u306e\u98df\u54c1\u306f\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u3092\u6d3b\u6027\u5316\u3057\u3001\u8178\u5185\u74b0\u5883\u3092\u6574\u3048\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u767a\u9175\u98df\u54c1\uff08\u30e8\u30fc\u30b0\u30eb\u30c8\u3001\u7d0d\u8c46\u3001\u30ad\u30e0\u30c1\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>FUT2\u907a\u4f1d\u5b50<\/strong> \u306e\u5909\u7570\u304c\u3042\u308b\u4eba\u306f\u3001\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\u304c\u6e1b\u5c11\u3057\u3084\u3059\u3044\u305f\u3081\u3001\u767a\u9175\u98df\u54c1\u3092\u7a4d\u6975\u7684\u306b\u6442\u308b\u3053\u3068\u3067\u8178\u5185\u74b0\u5883\u306e\u6539\u5584\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u6c34\u6eb6\u6027\u98df\u7269\u7e4a\u7dad\uff08\u30b4\u30dc\u30a6\u3001\u30d0\u30ca\u30ca\u3001\u30aa\u30fc\u30c4\u9ea6\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>SCFA\u751f\u6210\u95a2\u9023\u907a\u4f1d\u5b50\uff08FFAR2, FFAR3\uff09<\/strong> \u3092\u6d3b\u6027\u5316\u3057\u3001\u77ed\u9396\u8102\u80aa\u9178\u306e\u751f\u6210\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3067\u514d\u75ab\u8abf\u7bc0\u6a5f\u80fd\u3092\u5411\u4e0a\u3055\u305b\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff08\u30b5\u30fc\u30e2\u30f3\u3001\u30a2\u30de\u30cb\u6cb9\u3001\u30c1\u30a2\u30b7\u30fc\u30c9\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>NOD2\u907a\u4f1d\u5b50<\/strong> \u306b\u5909\u7570\u304c\u3042\u308b\u4eba\u306f\u3001\u8178\u306e\u708e\u75c7\u304c\u8d77\u3053\u308a\u3084\u3059\u3044\u305f\u3081\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u306e\u6442\u53d6\u304c\u6709\u52b9\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff08\u7dd1\u8336\u3001\u30ab\u30ab\u30aa\u3001\u30d6\u30eb\u30fc\u30d9\u30ea\u30fc\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>AHR\uff08\u30a2\u30ea\u30fc\u30eb\u70ad\u5316\u6c34\u7d20\u53d7\u5bb9\u4f53\uff09<\/strong> \u306e\u767a\u73fe\u3092\u4fc3\u9032\u3057\u3001\u8178\u5185\u306e\u514d\u75ab\u8abf\u6574\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41586-018-0602-y\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u7279\u306b\u3001\u98df\u7269\u7e4a\u7dad\u3084\u767a\u9175\u98df\u54c1\u306f\u8178\u5185\u306e\u77ed\u9396\u8102\u80aa\u9178\u306e\u7523\u751f\u3092\u5897\u3084\u3057\u3001\u708e\u75c7\u3092\u6291\u3048\u308b\u3053\u3068\u3067\u514d\u75ab\u529b\u3092\u9ad8\u3081\u308b\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-178f20d7-7fff-68e0-2e27-e3de8c688797\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4.3 \u8178\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/3676468_m-1024x683.jpg\" alt=\"\n\u7814\u7a76\u30fb\u79d1\u5b66\u8005\u30a4\u30e1\u30fc\u30b8\" class=\"wp-image-9687\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3676468_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3676468_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3676468_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3676468_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3676468_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8178\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u306f\u3001\u5916\u90e8\u304b\u3089\u306e\u75c5\u539f\u83cc\u3084\u6bd2\u7d20\u306e\u4fb5\u5165\u3092\u9632\u3050\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u3053\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u8178\u7ba1\u5185\u3067\u708e\u75c7\u304c\u767a\u751f\u3057\u3001\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u304c\u904e\u5270\u306b\u53cd\u5fdc\u3057\u3066\u3057\u307e\u3046\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u30d0\u30ea\u30a2\u6a5f\u80fd\u306b\u95a2\u308f\u308b\u4e3b\u306a\u907a\u4f1d\u5b50\u3068\u3057\u3066\u3001\u4ee5\u4e0b\u306e\u3082\u306e\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>OCLN\uff08\u30aa\u30af\u30eb\u30c7\u30a3\u30f3\uff09<\/strong>\uff1a\u8178\u306e\u7d30\u80de\u9593\u7d50\u5408\u3092\u5f37\u5316\u3059\u308b\u5f79\u5272\u3092\u6301\u3064\u3002\u5909\u7570\u304c\u3042\u308b\u3068\u8178\u306e\u900f\u904e\u6027\u304c\u9ad8\u307e\u308a\u3001\u7570\u7269\u304c\u4f53\u5185\u306b\u4fb5\u5165\u3057\u3084\u3059\u304f\u306a\u308b\u3002<\/li>\n\n\n\n<li><strong>CLDN1\uff08\u30af\u30ed\u30fc\u30c7\u30a3\u30f31\uff09<\/strong>\uff1a\u8178\u306e\u7c98\u819c\u306e\u5bc6\u7740\u5ea6\u3092\u8abf\u6574\u3059\u308b\u3002\u5909\u7570\u304c\u3042\u308b\u3068\u30ea\u30fc\u30ad\u30fc\u30ac\u30c3\u30c8\uff08\u8178\u6f0f\u308c\u75c7\u5019\u7fa4\uff09\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u306f\u3001<strong>L-\u30b0\u30eb\u30bf\u30df\u30f3<\/strong> \u3084 <strong>\u30d3\u30bf\u30df\u30f3D<\/strong> \u306e\u6442\u53d6\u304c\u52b9\u679c\u7684\u3067\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2018.02243\/full\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002\u7279\u306b\u3001L-\u30b0\u30eb\u30bf\u30df\u30f3\u306f\u8178\u306e\u7d30\u80de\u3092\u4fee\u5fa9\u3057\u3001\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u5f37\u5316\u3059\u308b\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4.4 \u8178\u5185\u74b0\u5883\u3068\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306e\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u8178\u3068\u8133\u306f<strong>\u8178\u8133\u76f8\u95a2<\/strong>\u3068\u547c\u3070\u308c\u308b\u5f37\u3044\u95a2\u4fc2\u3092\u6301\u3063\u3066\u304a\u308a\u3001\u30b9\u30c8\u30ec\u30b9\u306f\u8178\u5185\u74b0\u5883\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>5-HTTLPR\uff08\u30bb\u30ed\u30c8\u30cb\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u907a\u4f1d\u5b50\uff09<\/strong> \u306f\u3001\u8178\u5185\u3067\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u5206\u6ccc\u3092\u8abf\u6574\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3001\u3053\u308c\u304c\u5909\u7570\u3057\u3066\u3044\u308b\u3068\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5f31\u304f\u3001\u8178\u5185\u74b0\u5883\u304c\u60aa\u5316\u3057\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.pnas.org\/content\/117\/30\/18093\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>NR3C1\uff08\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u53d7\u5bb9\u4f53\u907a\u4f1d\u5b50\uff09<\/strong> \u306f\u3001\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u306e\u611f\u53d7\u6027\u3092\u8abf\u7bc0\u3057\u3001\u8178\u306e\u708e\u75c7\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u9069\u5207\u306b\u4fdd\u3064\u305f\u3081\u306b\u306f\u3001\u5341\u5206\u306a\u7761\u7720\u3068\u9069\u5ea6\u306a\u904b\u52d5\u304c\u91cd\u8981\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30b9\u3092\u8efd\u6e1b\u3057\u3001\u8178\u5185\u74b0\u5883\u3092\u6574\u3048\u308b\u305f\u3081\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u65b9\u6cd5\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30de\u30a4\u30f3\u30c9\u30d5\u30eb\u30cd\u30b9\u3084\u7791\u60f3<\/strong>\uff1a\u81ea\u5f8b\u795e\u7d4c\u3092\u6574\u3048\u3001\u8178\u306e\u50cd\u304d\u3092\u30b5\u30dd\u30fc\u30c8<\/li>\n\n\n\n<li><strong>\u9069\u5ea6\u306a\u904b\u52d5<\/strong>\uff1a\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027\u3092\u5411\u4e0a\u3055\u305b\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3092\u9ad8\u3081\u308b<\/li>\n\n\n\n<li><strong>\u767a\u9175\u98df\u54c1\u306e\u6442\u53d6<\/strong>\uff1a\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u5408\u6210\u3092\u4fc3\u9032\u3057\u3001\u7cbe\u795e\u7684\u5b89\u5b9a\u3092\u52a9\u3051\u308b<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u3068\u8178\u5185\u74b0\u5883\u306f\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u305d\u308c\u305e\u308c\u306e\u907a\u4f1d\u7684\u7279\u5fb4\u3092\u7406\u89e3\u3057\u3001\u9069\u5207\u306a\u98df\u4e8b\u30fb\u751f\u6d3b\u7fd2\u6163\u3092\u5b9f\u8df5\u3059\u308b\u3053\u3068\u3067\u3001\u514d\u75ab\u529b\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002\u500b\u5225\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u3082\u3068\u306b\u3001\u8178\u5185\u74b0\u5883\u3092\u6700\u9069\u5316\u3059\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u3001\u4eca\u5f8c\u3055\u3089\u306b\u6ce8\u76ee\u3055\u308c\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-178f20d7-7fff-68e0-2e27-e3de8c688797\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>5. \u907a\u4f1d\u5b50\u3068\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u591a\u69d8\u6027<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5.1 \u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u591a\u69d8\u6027\u3092\u6c7a\u5b9a\u3059\u308b\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h3>\n\n\n\n<p>\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u591a\u69d8\u6027\u306f\u3001\u514d\u75ab\u529b\u3084\u5065\u5eb7\u72b6\u614b\u306b\u5927\u304d\u304f\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u304c\u591a\u69d8\u3067\u3042\u308b\u307b\u3069\u3001\u514d\u75ab\u7cfb\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u53d6\u308c\u3001\u75c5\u539f\u4f53\u3078\u306e\u62b5\u6297\u529b\u304c\u5411\u4e0a\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/nature18846\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027\u3092\u6c7a\u5b9a\u3059\u308b\u8981\u56e0\u306b\u306f\u3001<strong>HLA\u907a\u4f1d\u5b50\uff08\u30d2\u30c8\u767d\u8840\u7403\u6297\u539f\u907a\u4f1d\u5b50\uff09<\/strong> \u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002HLA\u907a\u4f1d\u5b50\u306f\u514d\u75ab\u5fdc\u7b54\u3092\u8abf\u6574\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u7fa4\u3067\u3042\u308a\u3001\u7279\u5b9a\u306eHLA\u306e\u30d0\u30ea\u30a8\u30fc\u30b7\u30e7\u30f3\u3092\u6301\u3064\u4eba\u306f\u3001\u7279\u5b9a\u306e\u8178\u5185\u7d30\u83cc\u306e\u7a2e\u985e\u3092\u591a\u304f\u6301\u3064\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001HLA-DQ2\u3084HLA-DQ8\u3092\u6301\u3064\u4eba\u306f\u3001\u5c0f\u9ea6\u30b0\u30eb\u30c6\u30f3\u306b\u5bfe\u3059\u308b\u904e\u654f\u53cd\u5fdc\u3092\u793a\u3059\u3053\u3068\u304c\u3042\u308a\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u69cb\u6210\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/cell-host-microbe\/fulltext\/S1931-3128(15)00128-7\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>LCT\uff08\u30e9\u30af\u30bf\u30fc\u30bc\uff09\u907a\u4f1d\u5b50<\/strong> \u306e\u5909\u7570\u306f\u3001\u4e73\u7cd6\u4e0d\u8010\u75c7\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u3001\u4e73\u88fd\u54c1\u306e\u6d88\u5316\u80fd\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u9055\u3044\u306b\u3088\u308a\u3001\u4e73\u88fd\u54c1\u306e\u6442\u53d6\u304c\u8178\u5185\u7d30\u83cc\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u304c\u500b\u4eba\u3054\u3068\u306b\u7570\u306a\u308b\u3053\u3068\u3082\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-178f20d7-7fff-68e0-2e27-e3de8c688797\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5.2 \u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u591a\u69d8\u6027\u3092\u9ad8\u3081\u308b\u305f\u3081\u306e\u6226\u7565<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/24249680_m-1024x683.jpg\" alt=\"\u305f\u304f\u3055\u3093\u306e\u65b0\u9bae\u306a\u91ce\u83dc\" class=\"wp-image-7534\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/24249680_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/24249680_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/24249680_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/24249680_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/24249680_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u591a\u69d8\u6027\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u514d\u75ab\u529b\u3092\u5f37\u5316\u3057\u3001\u6162\u6027\u7684\u306a\u708e\u75c7\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u4ee5\u4e0b\u306e\u65b9\u6cd5\u304c\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u591a\u69d8\u6027\u3092\u9ad8\u3081\u308b\u305f\u3081\u306b\u6709\u52b9\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u69d8\u3005\u306a\u7a2e\u985e\u306e\u690d\u7269\u7531\u6765\u98df\u54c1\u3092\u6442\u53d6\u3059\u308b<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u6bce\u903130\u7a2e\u985e\u4ee5\u4e0a\u306e\u7570\u306a\u308b\u690d\u7269\u7531\u6765\u98df\u54c1\u3092\u6442\u53d6\u3059\u308b\u4eba\u306f\u3001\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027\u304c\u9ad8\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(18)31044-4\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n\n\n\n<li>\u91ce\u83dc\u3001\u679c\u7269\u3001\u8c46\u985e\u3001\u30ca\u30c3\u30c4\u3001\u7a2e\u5b50\u985e\u3092\u30d0\u30e9\u30f3\u30b9\u3088\u304f\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u767a\u9175\u98df\u54c1\u306e\u6442\u53d6\u3092\u5897\u3084\u3059<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30e8\u30fc\u30b0\u30eb\u30c8\u3001\u7d0d\u8c46\u3001\u5473\u564c\u3001\u30ad\u30e0\u30c1\u3001\u30b6\u30ef\u30fc\u30af\u30e9\u30a6\u30c8\u306a\u3069\u306e\u767a\u9175\u98df\u54c1\u306f\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u591a\u69d8\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u7279\u306b\u3001\u4f1d\u7d71\u7684\u306a\u767a\u9175\u98df\u54c1\u306b\u306f\u591a\u7a2e\u591a\u69d8\u306a\u5fae\u751f\u7269\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u8178\u5185\u306e\u5fae\u751f\u7269\u74b0\u5883\u3092\u8c4a\u304b\u306b\u3059\u308b\u52b9\u679c\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u3092\u610f\u8b58\u3057\u305f\u98df\u751f\u6d3b<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u8178\u5185\u7d30\u83cc\u306e\u30a8\u30b5\u3068\u306a\u308b\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u30aa\u30ea\u30b4\u7cd6\u3001\u30a4\u30cc\u30ea\u30f3\u3001\u30ec\u30b8\u30b9\u30bf\u30f3\u30c8\u30b9\u30bf\u30fc\u30c1\u306a\u3069\uff09\u3092\u591a\u304f\u542b\u3080\u98df\u54c1\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027\u3092\u4fc3\u9032\u3067\u304d\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u9069\u5ea6\u306a\u904b\u52d5<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u5b9a\u671f\u7684\u306a\u904b\u52d5\u3092\u884c\u3063\u3066\u3044\u308b\u4eba\u306f\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u591a\u69d8\u6027\u304c\u9ad8\u3044\u50be\u5411\u306b\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41591-019-0633-7\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n\n\n\n<li>\u6709\u9178\u7d20\u904b\u52d5\u3084\u8efd\u3044\u7b4b\u30c8\u30ec\u3092\u7fd2\u6163\u306b\u3059\u308b\u3053\u3068\u3067\u3001\u8178\u5185\u74b0\u5883\u3092\u6539\u5584\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-178f20d7-7fff-68e0-2e27-e3de8c688797\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5.3 \u907a\u4f1d\u5b50\u3068\u8178\u5185\u74b0\u5883\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u308b\u75be\u60a3\u30ea\u30b9\u30af<\/strong><\/h3>\n\n\n\n<p>\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u308b\u3068\u3001\u3055\u307e\u3056\u307e\u306a\u5065\u5eb7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u907a\u4f1d\u5b50\u3068\u8178\u5185\u7d30\u83cc\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u3001\u4ee5\u4e0b\u306e\u75be\u60a3\u30ea\u30b9\u30af\u304c\u5909\u5316\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u708e\u75c7\u6027\u8178\u75be\u60a3\uff08IBD\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>NOD2\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong> \u304c\u3042\u308b\u3068\u3001\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u3084\u3059\u304f\u3001\u30af\u30ed\u30fc\u30f3\u75c5\u3084\u6f70\u760d\u6027\u5927\u8178\u708e\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/nature11582\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n\n\n\n<li>\u77ed\u9396\u8102\u80aa\u9178\u306e\u751f\u6210\u3092\u4fc3\u3059\u98df\u54c1\uff08\u98df\u7269\u7e4a\u7dad\u3084\u767a\u9175\u98df\u54c1\uff09\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u4fdd\u3064\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u7cd6\u5c3f\u75c5\u3068\u8178\u5185\u7d30\u83cc<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>TCF7L2\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u8840\u7cd6\u5024\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308b\u4eba\u306f\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/nature18307\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n\n\n\n<li>\u8178\u5185\u7d30\u83cc\u306e\u7a2e\u985e\u306b\u3088\u3063\u3066\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304a\u308a\u3001\u8178\u5185\u74b0\u5883\u3092\u6574\u3048\u308b\u3053\u3068\u304c\u8840\u7cd6\u7ba1\u7406\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u80a5\u6e80\u3068\u8178\u5185\u30d5\u30ed\u30fc\u30e9<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>FTO\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u80a5\u6e80\u306e\u30ea\u30b9\u30af\u3092\u6c7a\u5b9a\u3059\u308b\u907a\u4f1d\u5b50\u306e\u4e00\u3064\u3067\u3059\u304c\u3001\u8178\u5185\u7d30\u83cc\u306e\u7d44\u6210\u306b\u3088\u3063\u3066\u305d\u306e\u5f71\u97ff\u304c\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41586-019-1282-9\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n\n\n\n<li>\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u3067\u3001FTO\u907a\u4f1d\u5b50\u306e\u5f71\u97ff\u3092\u6291\u3048\u3001\u5065\u5eb7\u7684\u306a\u4f53\u91cd\u7ba1\u7406\u304c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-178f20d7-7fff-68e0-2e27-e3de8c688797\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5.4 \u907a\u4f1d\u5b50\u89e3\u6790\u3092\u6d3b\u7528\u3057\u305f\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u8178\u5185\u30b1\u30a2<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31213107_m-1024x683.jpg\" alt=\"\n\u85ac\" class=\"wp-image-9694\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31213107_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31213107_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31213107_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31213107_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31213107_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u6700\u65b0\u306e\u7814\u7a76\u3067\u306f\u3001\u500b\u3005\u306e\u907a\u4f1d\u7684\u7279\u5fb4\u3092\u5206\u6790\u3057\u3001\u305d\u308c\u306b\u57fa\u3065\u3044\u305f\u6700\u9069\u306a\u8178\u5185\u30b1\u30a2\u3092\u63d0\u6848\u3059\u308b\u300c\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u6804\u990a\u5b66\u300d\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u53d7\u3051\u308b\u3053\u3068\u3067\u3001\u8178\u5185\u7d30\u83cc\u306e\u7d44\u6210\u3084\u514d\u75ab\u529b\u306e\u5f37\u5f31\u3092\u77e5\u308a\u3001\u3069\u306e\u3088\u3046\u306a\u98df\u751f\u6d3b\u304c\u9069\u3057\u3066\u3044\u308b\u304b\u3092\u5224\u65ad\u3067\u304d\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u907a\u4f1d\u5b50\u578b\u306b\u57fa\u3065\u3044\u305f\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u3084\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u306e\u63a8\u5968\u304c\u53ef\u80fd\u306b\u306a\u308a\u3001\u52b9\u679c\u7684\u306a\u8178\u5185\u74b0\u5883\u306e\u6539\u5584\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u7279\u306b\u3001AI\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u306e\u98df\u4e8b\u30a2\u30c9\u30d0\u30a4\u30b9\u3084\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u63d0\u4f9b\u304c\u9032\u3093\u3067\u304a\u308a\u3001\u4eca\u5f8c\u3055\u3089\u306b\u767a\u5c55\u3057\u3066\u3044\u304f\u5206\u91ce\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u591a\u69d8\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u306f\u3001\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u6c7a\u307e\u308b\u75be\u60a3\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3057\u3001\u5065\u5eb7\u7684\u306a\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u9069\u5207\u306a\u98df\u4e8b\u3001\u751f\u6d3b\u7fd2\u6163\u3001\u305d\u3057\u3066\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u8178\u306e\u5065\u5eb7\u3092\u6700\u9069\u5316\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-178f20d7-7fff-68e0-2e27-e3de8c688797\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>6. \u8178\u5185\u7d30\u83cc\u3068\u907a\u4f1d\u5b50\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u308b\u30db\u30eb\u30e2\u30f3\u8abf\u6574<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6.1 \u8178\u5185\u7d30\u83cc\u304c\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<p>\u8178\u5185\u7d30\u83cc\u306f\u3001\u514d\u75ab\u6a5f\u80fd\u3060\u3051\u3067\u306a\u304f\u3001\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306e\u8abf\u6574\u306b\u3082\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u8178\u5185\u7d30\u83cc\u304c\u751f\u6210\u3059\u308b\u4ee3\u8b1d\u7269\u8cea\u304c\u3001\u30db\u30eb\u30e2\u30f3\u306e\u751f\u6210\u3084\u5206\u6ccc\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30bb\u30ed\u30c8\u30cb\u30f3\uff08\u5e78\u798f\u30db\u30eb\u30e2\u30f3\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u7d0490%\u306f\u8178\u5185\u3067\u751f\u6210\u3055\u308c\u3066\u304a\u308a\u3001\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u4e71\u308c\u308b\u3068\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u751f\u6210\u91cf\u304c\u6e1b\u5c11\u3057\u3001\u7cbe\u795e\u7684\u306a\u4e0d\u5b89\u5b9a\u3055\u3084\u3046\u3064\u75c7\u72b6\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u4f8b\u3048\u3070\u3001<strong>Tph1\u907a\u4f1d\u5b50<\/strong> \u306f\u30bb\u30ed\u30c8\u30cb\u30f3\u5408\u6210\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u8178\u5185\u74b0\u5883\u304c\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u4e71\u308c\u3084\u3059\u304f\u306a\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41593-019-0481-6\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\uff08\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u904e\u5270\u306a\u30b9\u30c8\u30ec\u30b9\u306f\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u5d29\u3057\u3001\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u8178\u5185\u7d30\u83cc\u304c\u77ed\u9396\u8102\u80aa\u9178\u3092\u751f\u6210\u3059\u308b\u3053\u3068\u3067\u3001\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3092\u8abf\u6574\u3059\u308b\u4f5c\u7528\u304c\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>NR3C1\u907a\u4f1d\u5b50<\/strong> \u306f\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u53d7\u5bb9\u4f53\u306e\u611f\u53d7\u6027\u3092\u8abf\u6574\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u304a\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u62b5\u6297\u529b\u304c\u5f31\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.pnas.org\/content\/117\/30\/18093\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30a4\u30f3\u30b9\u30ea\u30f3\uff08\u8840\u7cd6\u8abf\u6574\u30db\u30eb\u30e2\u30f3\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u306f\u3001\u8840\u7cd6\u5024\u306e\u8abf\u6574\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001<strong>Bacteroides\uff08\u30d0\u30af\u30c6\u30ed\u30a4\u30c7\u30b9\uff09<\/strong> \u3068\u3044\u3046\u8178\u5185\u7d30\u83cc\u304c\u591a\u3044\u4eba\u306f\u3001\u8840\u7cd6\u5024\u304c\u5b89\u5b9a\u3057\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>TCF7L2\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u6c7a\u5b9a\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u8178\u5185\u7d30\u83cc\u306e\u5f71\u97ff\u3092\u5f37\u304f\u53d7\u3051\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/nature18307\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6.2 \u8178\u5185\u7d30\u83cc\u3068\u30db\u30eb\u30e2\u30f3\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u6574\u3048\u308b\u305f\u3081\u306e\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"576\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31230900_m-1024x576.jpg\" alt=\"\n\u30a2\u30dc\u30ab\u30c9\u30c8\u30fc\u30b9\u30c8\u306e\u3086\u3067\u5375\u30c8\u30c3\u30d4\u30f3\u30b0\" class=\"wp-image-9703\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31230900_m-1024x576.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31230900_m-300x169.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31230900_m-768x432.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31230900_m-1536x864.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31230900_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u3092\u9069\u5207\u306b\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u8178\u5185\u74b0\u5883\u306e\u8abf\u6574\u304c\u91cd\u8981\u3067\u3059\u3002\u4ee5\u4e0b\u306e\u65b9\u6cd5\u304c\u3001\u8178\u5185\u7d30\u83cc\u3092\u901a\u3058\u3066\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u3092\u6539\u5584\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u767a\u9175\u98df\u54c1\u3092\u6442\u53d6\u3059\u308b<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30e8\u30fc\u30b0\u30eb\u30c8\u3001\u30ad\u30e0\u30c1\u3001\u7d0d\u8c46\u306a\u3069\u306e\u767a\u9175\u98df\u54c1\u306f\u3001\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u6574\u3048\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u751f\u6210\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u77ed\u9396\u8102\u80aa\u9178\u306e\u751f\u6210\u3092\u4fc3\u3059\u98df\u4e8b<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u6c34\u6eb6\u6027\u98df\u7269\u7e4a\u7dad\uff08\u30aa\u30fc\u30c4\u9ea6\u3001\u30a2\u30dc\u30ab\u30c9\u3001\u6d77\u85fb\uff09\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u8178\u5185\u7d30\u83cc\u304c\u77ed\u9396\u8102\u80aa\u9178\u3092\u751f\u6210\u3057\u3001\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306e\u5206\u6ccc\u3092\u8abf\u6574\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u8178\u5185\u74b0\u5883\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7791\u60f3\u3084\u30e8\u30ac\u3001\u8efd\u3044\u904b\u52d5\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u3001\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u306e\u5206\u6ccc\u3092\u6291\u3048\u3001\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u5b89\u5b9a\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-178f20d7-7fff-68e0-2e27-e3de8c688797\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6.3 \u8178\u5185\u7d30\u83cc\u3068\u907a\u4f1d\u5b50\u306b\u3088\u308b\u81ea\u5f8b\u795e\u7d4c\u8abf\u6574<\/strong><\/h3>\n\n\n\n<p>\u8178\u306f\u300c\u7b2c\u4e8c\u306e\u8133\u300d\u3068\u3082\u547c\u3070\u308c\u3001\u81ea\u5f8b\u795e\u7d4c\u3068\u5bc6\u63a5\u306b\u9023\u643a\u3057\u3066\u3044\u307e\u3059\u3002\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u308b\u3068\u3001\u81ea\u5f8b\u795e\u7d4c\u306e\u4e71\u308c\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u514d\u75ab\u529b\u306e\u4f4e\u4e0b\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>GABA\uff08\u30ea\u30e9\u30c3\u30af\u30b9\u30db\u30eb\u30e2\u30f3\uff09\u3068\u8178\u5185\u7d30\u83cc<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>GABA\uff08\u03b3-\u30a2\u30df\u30ce\u916a\u9178\uff09\u306f\u30ea\u30e9\u30c3\u30af\u30b9\u52b9\u679c\u3092\u3082\u305f\u3089\u3059\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3067\u3042\u308a\u3001\u8178\u5185\u7d30\u83cc\u304c\u305d\u306e\u751f\u6210\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>GAD1\u907a\u4f1d\u5b50<\/strong> \u306fGABA\u306e\u751f\u6210\u306b\u95a2\u4e0e\u3057\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba\u306f\u3001\u8178\u5185\u74b0\u5883\u304c\u30b9\u30c8\u30ec\u30b9\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u304f\u306a\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41467-020-17861-4\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u81ea\u5f8b\u795e\u7d4c\u3092\u6574\u3048\u308b\u98df\u4e8b<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3<\/strong>\uff08\u30d0\u30ca\u30ca\u3001\u30ca\u30c3\u30c4\u3001\u5927\u8c46\uff09\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u751f\u6210\u3092\u4fc3\u3057\u3001\u81ea\u5f8b\u795e\u7d4c\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30aa\u30e1\u30ac3\u8102\u80aa\u9178<\/strong>\uff08\u30b5\u30fc\u30e2\u30f3\u3001\u30c1\u30a2\u30b7\u30fc\u30c9\uff09\u3092\u6442\u308b\u3053\u3068\u3067\u3001\u4ea4\u611f\u795e\u7d4c\u306e\u904e\u5270\u306a\u6d3b\u6027\u5316\u3092\u9632\u3050\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6.4 \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u8178\u306e\u5065\u5eb7\u7dad\u6301<\/strong><\/h3>\n\n\n\n<p>\u8fd1\u5e74\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u3066\u500b\u3005\u306e\u8178\u5185\u74b0\u5883\u306b\u5408\u308f\u305b\u305f\u5065\u5eb7\u7ba1\u7406\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8178\u5185\u7d30\u83cc\u306e\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u53d7\u3051\u308b\u3053\u3068\u3067\u3001\u81ea\u5206\u306e\u8178\u5185\u7d30\u83cc\u306e\u7a2e\u985e\u3084\u30d0\u30e9\u30f3\u30b9\u3092\u628a\u63e1\u3057\u3001\u6700\u9069\u306a\u98df\u4e8b\u3084\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u9078\u629e\u3067\u304d\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u81ea\u5206\u306e\u907a\u4f1d\u5b50\u3068\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306b\u6700\u9069\u306a\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u514d\u75ab\u529b\u306e\u5f37\u5316\u3084\u708e\u75c7\u306e\u6291\u5236\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3092\u6d3b\u7528\u3057\u305f\u8178\u306e\u5065\u5eb7\u6539\u5584<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u751f\u6d3b\u7fd2\u6163\u3084\u98df\u4e8b\u306e\u6539\u5584\u306b\u3088\u3063\u3066\u3001\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u3092\u5909\u5316\u3055\u305b\u308b\u300c\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u300d\u306e\u7814\u7a76\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u8178\u5185\u7d30\u83cc\u3092\u9069\u5207\u306b\u7ba1\u7406\u3059\u308b\u3053\u3068\u3067\u3001\u907a\u4f1d\u7684\u306a\u708e\u75c7\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41591-019-0633-7\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-178f20d7-7fff-68e0-2e27-e3de8c688797\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>6.5 \u8178\u5185\u74b0\u5883\u3068\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-1024x585.jpg\" alt=\"\" class=\"wp-image-9460\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8178\u5185\u74b0\u5883\u306f\u3001\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306b\u3082\u5bc6\u63a5\u306b\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002\u8178\u5185\u7d30\u83cc\u304c\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3092\u5408\u6210\u30fb\u8abf\u6574\u3059\u308b\u3053\u3068\u3067\u3001\u4e0d\u5b89\u3084\u30b9\u30c8\u30ec\u30b9\u3078\u306e\u8010\u6027\u304c\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u3068\u3046\u3064\u75c5\u306e\u95a2\u9023\u6027<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>Lactobacillus\uff08\u30e9\u30af\u30c8\u30d0\u30c1\u30eb\u30b9\uff09<\/strong> \u3084 <strong>Bifidobacterium\uff08\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\uff09<\/strong> \u306f\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u3084\u30c9\u30fc\u30d1\u30df\u30f3\u306e\u5408\u6210\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u6c17\u5206\u3092\u5b89\u5b9a\u3055\u305b\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u83cc\u304c\u5c11\u306a\u3044\u3068\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u3046\u3064\u75c7\u72b6\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41564-018-0337-x\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>BDNF\u907a\u4f1d\u5b50\u3068\u8178\u5185\u7d30\u83cc<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>BDNF\uff08\u8133\u7531\u6765\u795e\u7d4c\u6804\u990a\u56e0\u5b50\uff09<\/strong> \u907a\u4f1d\u5b50\u306f\u3001\u8133\u306e\u795e\u7d4c\u53ef\u5851\u6027\u3092\u4fc3\u9032\u3057\u3001\u8a18\u61b6\u3084\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002BDNF\u306e\u767a\u73fe\u306f\u8178\u5185\u74b0\u5883\u3068\u5bc6\u63a5\u306b\u95a2\u4fc2\u3057\u3066\u304a\u308a\u3001\u77ed\u9396\u8102\u80aa\u9178\u306e\u751f\u6210\u3092\u4fc3\u3059\u98df\u7269\u7e4a\u7dad\u304c\u591a\u3044\u98df\u4e8b\u3092\u3068\u308b\u3053\u3068\u3067\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u3092\u6d3b\u6027\u5316\u3067\u304d\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41593-019-0481-6\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u306b\u3088\u308b\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u6539\u5584<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\uff08\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\uff09\u306e\u5206\u6ccc\u304c\u4f4e\u4e0b\u3057\u3001\u30ea\u30e9\u30c3\u30af\u30b9\u52b9\u679c\u304c\u5f97\u3089\u308c\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001<strong>Lactobacillus rhamnosus<\/strong> \u306e\u6442\u53d6\u306f\u3001\u4e0d\u5b89\u611f\u306e\u8efd\u6e1b\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.pnas.org\/content\/108\/38\/16050\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u8178\u3068\u8133\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u7406\u89e3\u3057\u3001\u8178\u5185\u74b0\u5883\u3092\u6574\u3048\u308b\u3053\u3068\u304c\u3001\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u3092\u5411\u4e0a\u3055\u305b\u308b\u65b0\u305f\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-178f20d7-7fff-68e0-2e27-e3de8c688797\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<p><strong>\u307e\u3068\u3081<\/strong><\/p>\n\n\n\n<p>\u8178\u5185\u74b0\u5883\u306f\u514d\u75ab\u529b\u3084\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u3001\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306b\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u907a\u4f1d\u5b50\u306f\u8178\u5185\u7d30\u83cc\u306e\u7d44\u6210\u3084\u50cd\u304d\u3092\u5de6\u53f3\u3057\u307e\u3059\u3002<strong>FUT2<\/strong> \u3084 <strong>NOD2<\/strong> \u306a\u3069\u306e\u907a\u4f1d\u5b50\u304c\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u3084\u708e\u75c7\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001<strong>TCF7L2<\/strong> \u306f\u8840\u7cd6\u8abf\u6574\u3001<strong>BDNF<\/strong> \u306f\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8178\u5185\u7d30\u83cc\u3092\u6574\u3048\u308b\u305f\u3081\u306b\u3001<strong>\u767a\u9175\u98df\u54c1\u3001\u98df\u7269\u7e4a\u7dad\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178<\/strong> \u3092\u6442\u53d6\u3057\u3001\u9069\u5ea6\u306a\u904b\u52d5\u3084\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u3092\u884c\u3046\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u3001\u500b\u5225\u306b\u6700\u9069\u306a\u8178\u306e\u30b1\u30a2\u3092\u5b9f\u8df5\u3059\u308b\u3053\u3068\u3067\u3001\u514d\u75ab\u529b\u5411\u4e0a\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u8178\u306f\u300c\u7b2c\u4e8c\u306e\u8133\u300d\u3068\u3082\u547c\u3070\u308c\u3001\u6d88\u5316\u3060\u3051\u3067\u306a\u304f\u3001\u514d\u75ab\u6a5f\u80fd\u3084\u7cbe\u795e\u72b6\u614b\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u91cd\u8981\u306a\u81d3\u5668\u3067\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u3084\u8178\u306e\u5065\u5eb7\u304c\u907a\u4f1d\u7684\u8981\u56e0\u3068\u6df1\u304f\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u306f\u8178\u5185\u74b0 [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":9673,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9672","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/9672","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=9672"}],"version-history":[{"count":1,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/9672\/revisions"}],"predecessor-version":[{"id":9710,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/9672\/revisions\/9710"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/9673"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=9672"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=9672"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=9672"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}