{"id":9711,"date":"2025-03-12T04:20:46","date_gmt":"2025-03-12T04:20:46","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=9711"},"modified":"2025-03-12T04:20:47","modified_gmt":"2025-03-12T04:20:47","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e9%85%b8%e7%b4%a0%e5%88%a9%e7%94%a8%e5%8a%b9%e7%8e%87%ef%bc%9a%e3%83%88%e3%83%ac%e3%83%bc%e3%83%8b%e3%83%b3%e3%82%b0%e6%88%90%e6%9e%9c%e3%82%92%e4%b8%8a%e3%81%92","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e9%85%b8%e7%b4%a0%e5%88%a9%e7%94%a8%e5%8a%b9%e7%8e%87%ef%bc%9a%e3%83%88%e3%83%ac%e3%83%bc%e3%83%8b%e3%83%b3%e3%82%b0%e6%88%90%e6%9e%9c%e3%82%92%e4%b8%8a%e3%81%92\/","title":{"rendered":"\u907a\u4f1d\u5b50\u3068\u9178\u7d20\u5229\u7528\u52b9\u7387\uff1a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6210\u679c\u3092\u4e0a\u3052\u308b\u9375"},"content":{"rendered":"\n<p>\u9178\u7d20\u5229\u7528\u52b9\u7387\u306f\u30b9\u30dd\u30fc\u30c4\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3084\u6301\u4e45\u529b\u3092\u6c7a\u5b9a\u3059\u308b\u91cd\u8981\u306a\u8981\u56e0\u3067\u3059\u3002\u9178\u7d20\u3092\u52b9\u7387\u3088\u304f\u7b4b\u8089\u306b\u4f9b\u7d66\u3057\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u3057\u3066\u5229\u7528\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u5bc6\u63a5\u306b\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u9178\u7d20\u306e\u8f38\u9001\u3084\u4ee3\u8b1d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u52b9\u679c\u3084\u9069\u5fdc\u306b\u9055\u3044\u3092\u751f\u3058\u3055\u305b\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u9178\u7d20\u5229\u7528\u52b9\u7387\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u3068\u305d\u306e\u5f71\u97ff\u3001\u305d\u3057\u3066\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6210\u679c\u3092\u6700\u5927\u5316\u3059\u308b\u65b9\u6cd5\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>1. \u9178\u7d20\u5229\u7528\u52b9\u7387\u3068\u306f\uff1f<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1.1 VO\u2082max\u3068\u6301\u4e45\u529b\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p><strong>\u6700\u5927\u9178\u7d20\u6442\u53d6\u91cf\uff08VO\u2082max\uff09<\/strong> \u306f\u3001\u904b\u52d5\u6642\u306b\u4f53\u304c\u3069\u308c\u3060\u3051\u306e\u9178\u7d20\u3092\u6d88\u8cbb\u3067\u304d\u308b\u304b\u3092\u793a\u3059\u6307\u6a19\u3067\u3059\u3002VO\u2082max\u304c\u9ad8\u3044\u307b\u3069\u3001\u7b4b\u8089\u306b\u9178\u7d20\u3092\u52b9\u7387\u3088\u304f\u4f9b\u7d66\u3057\u3001\u6301\u4e45\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>VO\u2082max\u306f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306b\u3088\u3063\u3066\u5411\u4e0a\u3057\u307e\u3059\u304c\u3001<strong>\u907a\u4f1d\u7684\u8981\u56e0\u304c40\u301c50\uff05\u5f71\u97ff\u3059\u308b<\/strong>\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41562-020-00991-8\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002\u3064\u307e\u308a\u3001\u9069\u5207\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3063\u3066\u3082\u3001\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066VO\u2082max\u306e\u4f38\u3073\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1.2 \u9178\u7d20\u4f9b\u7d66\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d<\/strong><\/h3>\n\n\n\n<p>\u9178\u7d20\u5229\u7528\u52b9\u7387\u306b\u306f\u3001\u4ee5\u4e0b\u306e3\u3064\u306e\u8981\u7d20\u304c\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u9178\u7d20\u306e\u904b\u642c<\/strong>\uff08\u80ba \u2192 \u8840\u6db2 \u2192 \u7b4b\u8089\uff09<\/li>\n\n\n\n<li><strong>\u9178\u7d20\u306e\u5229\u7528<\/strong>\uff08\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3067\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u5909\u63db\uff09<\/li>\n\n\n\n<li><strong>\u9178\u7d20\u3092\u4f7f\u3063\u305fATP\uff08\u30a8\u30cd\u30eb\u30ae\u30fc\uff09\u306e\u7523\u751f\u52b9\u7387<\/strong><\/li>\n<\/ol>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u30d7\u30ed\u30bb\u30b9\u306f\u3001\u305d\u308c\u305e\u308c\u7570\u306a\u308b\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u8abf\u6574\u3055\u308c\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a8\u30fc\u30b7\u30e7\u30f3\u304c\u30b9\u30dd\u30fc\u30c4\u306e\u9069\u6027\u3084\u6301\u4e45\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c61653b3-7fff-7188-3271-76ca6d741236\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. \u9178\u7d20\u5229\u7528\u306b\u95a2\u308f\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2.1 ACE\u907a\u4f1d\u5b50\uff08\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d20\uff09<\/strong><\/h3>\n\n\n\n<p><strong>ACE\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u8840\u5727\u3084\u8840\u6d41\u3092\u8abf\u6574\u3057\u3001\u9178\u7d20\u306e\u904b\u642c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306b\u306f <strong>I\u578b\uff08\u633f\u5165\u578b\uff09<\/strong> \u3068 <strong>D\u578b\uff08\u6b20\u5931\u578b\uff09<\/strong> \u306e2\u3064\u306e\u30d0\u30ea\u30a8\u30fc\u30b7\u30e7\u30f3\u304c\u3042\u308a\u3001\u305d\u308c\u305e\u308c\u7570\u306a\u308b\u30b9\u30dd\u30fc\u30c4\u9069\u6027\u3092\u6301\u3064\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>I\u578b\uff08II\u578b\uff09<\/strong>\uff1a\u6301\u4e45\u529b\u306b\u512a\u308c\u305f\u30bf\u30a4\u30d7\u3002VO\u2082max\u306e\u5411\u4e0a\u304c\u671f\u5f85\u3067\u304d\u3001\u30de\u30e9\u30bd\u30f3\u3084\u9577\u8ddd\u96e2\u30e9\u30f3\u30ca\u30fc\u306b\u9069\u3057\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>D\u578b\uff08DD\u578b\uff09<\/strong>\uff1a\u7b4b\u529b\u3084\u30b9\u30d7\u30ea\u30f3\u30c8\u80fd\u529b\u306b\u512a\u308c\u305f\u30bf\u30a4\u30d7\u3002\u77ed\u8ddd\u96e2\u8d70\u3084\u30d1\u30ef\u30fc\u30b9\u30dd\u30fc\u30c4\u5411\u304d\u3002<\/li>\n\n\n\n<li><strong>ID\u578b<\/strong>\uff1a\u4e21\u65b9\u306e\u7279\u6027\u3092\u6301\u3064\u4e2d\u9593\u578b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u7814\u7a76\u3067\u306f\u3001\u6301\u4e45\u7cfb\u30a2\u30b9\u30ea\u30fc\u30c8\u306e\u591a\u304f\u304c <strong>II\u578b\u306eACE\u907a\u4f1d\u5b50<\/strong> \u3092\u6301\u3064\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/ejhg2015248\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c61653b3-7fff-7188-3271-76ca6d741236\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2.2 ACTN3\u907a\u4f1d\u5b50\uff08\u03b1-\u30a2\u30af\u30c1\u30cb\u30f3-3\uff09<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/23797470_m-1024x683.jpg\" alt=\"\n\u91cd\u91cf\u6319\u3052\u3092\u3059\u308b\u5973\u6027\u306e\u5f8c\u308d\u3067\u898b\u5b88\u308b\u7537\u6027\" class=\"wp-image-9719\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23797470_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23797470_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23797470_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23797470_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23797470_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><strong>ACTN3\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u901f\u7b4b\u7e4a\u7dad\u306e\u767a\u9054\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3001\u6301\u4e45\u529b\u3068\u30b9\u30d7\u30ea\u30f3\u30c8\u80fd\u529b\u306e\u9055\u3044\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306b\u306f <strong>RR\u578b\u3001RX\u578b\u3001XX\u578b<\/strong> \u306e3\u7a2e\u985e\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>RR\u578b\uff08\u901f\u7b4b\u512a\u4f4d\uff09<\/strong>\uff1a\u30d1\u30ef\u30fc\u7cfb\u30b9\u30dd\u30fc\u30c4\uff08\u77ed\u8ddd\u96e2\u8d70\u3001\u30a6\u30a7\u30a4\u30c8\u30ea\u30d5\u30c6\u30a3\u30f3\u30b0\uff09\u5411\u304d\u3002<\/li>\n\n\n\n<li><strong>XX\u578b\uff08\u9045\u7b4b\u512a\u4f4d\uff09<\/strong>\uff1a\u6301\u4e45\u529b\u7cfb\u30b9\u30dd\u30fc\u30c4\uff08\u30de\u30e9\u30bd\u30f3\u3001\u30c8\u30e9\u30a4\u30a2\u30b9\u30ed\u30f3\uff09\u5411\u304d\u3002<\/li>\n\n\n\n<li><strong>RX\u578b<\/strong>\uff1a\u4e2d\u9593\u578b\u3067\u3001\u9069\u5fdc\u529b\u304c\u9ad8\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u6301\u4e45\u529b\u30a2\u30b9\u30ea\u30fc\u30c8\u306e\u591a\u304f\u306f <strong>XX\u578b<\/strong> \u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC421889\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2.3 EPAS1\u907a\u4f1d\u5b50\uff08\u4f4e\u9178\u7d20\u5fdc\u7b54\u56e0\u5b50\uff09<\/strong><\/h3>\n\n\n\n<p><strong>EPAS1\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u4f4e\u9178\u7d20\u74b0\u5883\uff08\u9ad8\u5730\u306a\u3069\uff09\u3067\u306e\u9178\u7d20\u5229\u7528\u3092\u8abf\u6574\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3001\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u9069\u5fdc\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u30c1\u30d9\u30c3\u30c8\u6c11\u65cf\u3084\u30a8\u30c1\u30aa\u30d4\u30a2\u306e\u30de\u30e9\u30bd\u30f3\u30e9\u30f3\u30ca\u30fc\u306f\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u7279\u7570\u306a\u5909\u7570\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/nature14679\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u3092\u6301\u3064\u4eba\u306f\u3001\u4f4e\u9178\u7d20\u74b0\u5883\u3067\u3082\u9ad8\u3044\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3092\u767a\u63ee\u3057\u3084\u3059\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c61653b3-7fff-7188-3271-76ca6d741236\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3.1 \u907a\u4f1d\u5b50\u5225\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u3001\u6700\u9069\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u65b9\u6cd5\u306f\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ACE II\u578b &amp; ACTN3 XX\u578b<\/strong> \u2192 \u6709\u9178\u7d20\u904b\u52d5\u3092\u4e2d\u5fc3\u306b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3057\u3001\u6301\u4e45\u529b\u5411\u4e0a\u3092\u72d9\u3046\u3002<\/li>\n\n\n\n<li><strong>ACE DD\u578b &amp; ACTN3 RR\u578b<\/strong> \u2192 \u9ad8\u5f37\u5ea6\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08HIIT\uff09\u3067\u30d1\u30ef\u30fc\u3068\u30b9\u30d4\u30fc\u30c9\u3092\u5f37\u5316\u3002<\/li>\n\n\n\n<li><strong>EPAS1\u9ad8\u767a\u73fe\u578b<\/strong> \u2192 \u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3067\u52b9\u679c\u7684\u306a\u9178\u7d20\u9069\u5fdc\u3092\u4fc3\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3.2 \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u306e\u5411\u4e0a<\/strong><\/h3>\n\n\n\n<p>\u9178\u7d20\u5229\u7528\u306e\u6700\u7d42\u6bb5\u968e\u3067\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u751f\u7523\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u3068\u3057\u3066 <strong>PGC-1\u03b1<\/strong> \u304c\u3042\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u9ad8\u3081\u308b\u3053\u3068\u3067\u3001\u6301\u4e45\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/cell-metabolism\/fulltext\/S1550-4131(04)00253-2\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>PGC-1\u03b1\u3092\u6d3b\u6027\u5316\u3059\u308b\u65b9\u6cd5\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u5f37\u5ea6\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08HIIT\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u4f4e\u9178\u7d20\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3084\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u306e\u6442\u53d6<\/strong>\uff08\u30d6\u30c9\u30a6\u3001\u8d64\u30ef\u30a4\u30f3\u3001\u30ca\u30c3\u30c4\uff09<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-c61653b3-7fff-7188-3271-76ca6d741236\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>4. \u9178\u7d20\u5229\u7528\u52b9\u7387\u3092\u9ad8\u3081\u308b\u6804\u990a\u6226\u7565<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31595733_m-1024x585.jpg\" alt=\"\n\u725b\u8089\u3000\u80a9\u30ed\u30fc\u30b9\u5207\u843d\u3057\" class=\"wp-image-9726\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31595733_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31595733_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31595733_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31595733_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31595733_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4.1 \u9244\u5206\u3068\u9178\u7d20\u904b\u642c<\/strong><\/h3>\n\n\n\n<p>\u9178\u7d20\u3092\u904b\u3076\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u306e\u5408\u6210\u306b\u306f <strong>HFE\u907a\u4f1d\u5b50<\/strong> \u304c\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u907a\u4f1d\u7684\u306b\u9244\u306e\u5438\u53ce\u304c\u60aa\u3044\u4eba\u306f\u3001\u9244\u5206\u88dc\u7d66\u304c\u91cd\u8981\u306b\u306a\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC479958\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u9244\u3092\u591a\u304f\u542b\u3080\u98df\u54c1\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8d64\u8eab\u8089<\/strong>\uff08\u725b\u8089\u3001\u30ec\u30d0\u30fc\uff09<\/li>\n\n\n\n<li><strong>\u307b\u3046\u308c\u3093\u8349\u3001\u30b1\u30fc\u30eb<\/strong>\uff08\u690d\u7269\u7531\u6765\u306e\u9244\uff09<\/li>\n\n\n\n<li><strong>\u30d3\u30bf\u30df\u30f3C\u3092\u4e00\u7dd2\u306b\u6442\u53d6\u3059\u308b\u3068\u5438\u53ce\u7387\u30a2\u30c3\u30d7<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4.2 \u6297\u9178\u5316\u7269\u8cea\u3068\u75b2\u52b4\u56de\u5fa9<\/strong><\/h3>\n\n\n\n<p>\u904b\u52d5\u4e2d\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u8efd\u6e1b\u3059\u308b\u305f\u3081\u3001\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3084\u6297\u9178\u5316\u30d3\u30bf\u30df\u30f3\uff08C\u30fbE\uff09\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6297\u9178\u5316\u98df\u54c1\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d6\u30eb\u30fc\u30d9\u30ea\u30fc\u3001\u30c0\u30fc\u30af\u30c1\u30e7\u30b3\u30ec\u30fc\u30c8\u3001\u7dd1\u8336<\/strong><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u3068\u9178\u7d20\u5229\u7528\u52b9\u7387\u306e\u95a2\u4fc2\u3092\u7406\u89e3\u3057\u3001\u500b\u3005\u306e\u907a\u4f1d\u7684\u7279\u6027\u306b\u57fa\u3065\u3044\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3084\u6804\u990a\u6226\u7565\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u3001\u6700\u5927\u9650\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u5411\u4e0a\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>5. \u907a\u4f1d\u5b50\u3068\u56de\u5fa9\u529b\uff1a\u9178\u7d20\u5229\u7528\u52b9\u7387\u3068\u75b2\u52b4\u56de\u5fa9\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5.1 HIF-1\u03b1\u907a\u4f1d\u5b50\u3068\u4f4e\u9178\u7d20\u74b0\u5883\u3078\u306e\u9069\u5fdc<\/strong><\/h3>\n\n\n\n<p><strong>HIF-1\u03b1\uff08\u4f4e\u9178\u7d20\u8a98\u5c0e\u56e0\u5b501\u03b1\uff09<\/strong> \u306f\u3001\u4f4e\u9178\u7d20\u72b6\u614b\u306b\u304a\u3051\u308b\u7d30\u80de\u306e\u9069\u5fdc\u3092\u8abf\u7bc0\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u3067\u3059\u3002HIF-1\u03b1\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u3068\u3001\u9178\u7d20\u4e0d\u8db3\u306e\u74b0\u5883\u4e0b\u3067\u3082ATP\u306e\u751f\u6210\u304c\u7dad\u6301\u3055\u308c\u3001\u6301\u4e45\u529b\u3084\u56de\u5fa9\u529b\u304c\u5411\u4e0a\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/nm.3217\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u4fc3\u3059\u65b9\u6cd5\u3068\u3057\u3066\u3001\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3084\u4f4e\u9178\u7d20\u74b0\u5883\u3067\u306e\u904b\u52d5\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u9178\u7d20\u904b\u642c\u80fd\u529b\u304c\u5411\u4e0a\u3057\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u5f8c\u306e\u56de\u5fa9\u304c\u65e9\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>HIF-1\u03b1\u306e\u767a\u73fe\u3092\u9ad8\u3081\u308b\u98df\u4e8b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d3\u30fc\u30c8\u30eb\u30fc\u30c8\uff08\u8d64\u30d3\u30fc\u30c4\uff09<\/strong>\uff1a\u785d\u9178\u5869\u304c\u8c4a\u5bcc\u3067\u3001\u4e00\u9178\u5316\u7a92\u7d20\uff08NO\uff09\u751f\u6210\u3092\u4fc3\u3057\u3001\u9178\u7d20\u4f9b\u7d66\u3092\u6539\u5584\u3002<\/li>\n\n\n\n<li><strong>\u30b1\u30eb\u30bb\u30c1\u30f3\uff08\u30bf\u30de\u30cd\u30ae\u3001\u30d6\u30ed\u30c3\u30b3\u30ea\u30fc\uff09<\/strong>\uff1aHIF-1\u03b1\u306e\u5b89\u5b9a\u6027\u3092\u5411\u4e0a\u3055\u305b\u308b\u53ef\u80fd\u6027\u3042\u308a\u3002<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-c61653b3-7fff-7188-3271-76ca6d741236\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5.2 NRF2\u907a\u4f1d\u5b50\u3068\u6297\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u8010\u6027<\/strong><\/h3>\n\n\n\n<p>\u6301\u4e45\u904b\u52d5\u4e2d\u3001\u9178\u7d20\u6d88\u8cbb\u91cf\u304c\u5897\u52a0\u3059\u308b\u3068\u3001\u6d3b\u6027\u9178\u7d20\uff08ROS\uff09\u304c\u767a\u751f\u3057\u3001\u7b4b\u8089\u306b\u30c0\u30e1\u30fc\u30b8\u3092\u4e0e\u3048\u307e\u3059\u3002\u3053\u308c\u3092\u6291\u5236\u3059\u308b\u305f\u3081\u306b\u91cd\u8981\u306a\u306e\u304c <strong>NRF2\uff08Nuclear Factor Erythroid 2-Related Factor 2\uff09<\/strong> \u3068\u3044\u3046\u907a\u4f1d\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<p>NRF2\u306f\u6297\u9178\u5316\u9175\u7d20\uff08SOD\u3001GPX\uff09\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3057\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u7d30\u80de\u3092\u5b88\u308a\u307e\u3059\u3002NRF2\u306e\u767a\u73fe\u304c\u9ad8\u3044\u4eba\u306f\u3001\u904b\u52d5\u5f8c\u306e\u7b4b\u8089\u30c0\u30e1\u30fc\u30b8\u304c\u5c11\u306a\u304f\u3001\u56de\u5fa9\u304c\u65e9\u3044\u50be\u5411\u306b\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-018-25219-x\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>NRF2\u3092\u6d3b\u6027\u5316\u3059\u308b\u6804\u990a\u7d20\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30b9\u30eb\u30d5\u30a9\u30e9\u30d5\u30a1\u30f3\uff08\u30d6\u30ed\u30c3\u30b3\u30ea\u30fc\u3001\u30ab\u30ea\u30d5\u30e9\u30ef\u30fc\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\uff08\u8d64\u30ef\u30a4\u30f3\u3001\u30d6\u30c9\u30a6\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u7dd1\u8336\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff08EGCG\uff09<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5.3 \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5065\u5eb7\u7dad\u6301\u3068\u907a\u4f1d\u5b50\u306e\u5f79\u5272<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31075536_m-1024x585.jpg\" alt=\"\" class=\"wp-image-9488\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31075536_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31075536_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31075536_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31075536_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31075536_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u9178\u7d20\u5229\u7528\u52b9\u7387\u3092\u9ad8\u3081\u308b\u305f\u3081\u306b\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u3092\u6700\u9069\u5316\u3059\u308b\u3053\u3068\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002<strong>PGC-1\u03b1\uff08PPARGC1A\uff09<\/strong> \u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u65b0\u751f\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u8abf\u6574\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3001\u6301\u4e45\u529b\u306b\u76f4\u7d50\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/cell-metabolism\/fulltext\/S1550-4131(04)00253-2\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>PGC-1\u03b1\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u65b9\u6cd5\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u5f37\u5ea6\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08HIIT\uff09<\/strong>\uff1a\u77ed\u6642\u9593\u306e\u9ad8\u5f37\u5ea6\u904b\u52d5\u304cPGC-1\u03b1\u306e\u767a\u73fe\u3092\u5897\u52a0\u3055\u305b\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30ab\u30ed\u30ea\u30fc\u5236\u9650<\/strong>\uff1a\u9069\u5ea6\u306a\u65ad\u98df\u3084\u4f4e\u70ad\u6c34\u5316\u7269\u98df\u304c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5065\u5eb7\u3092\u4fc3\u9032\u3002<\/li>\n\n\n\n<li><strong>\u30a6\u30b3\u30f3\uff08\u30af\u30eb\u30af\u30df\u30f3\uff09<\/strong>\uff1a\u6297\u708e\u75c7\u4f5c\u7528\u3092\u6301\u3061\u3001PGC-1\u03b1\u306e\u767a\u73fe\u3092\u5897\u3084\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-c61653b3-7fff-7188-3271-76ca6d741236\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>6. \u907a\u4f1d\u5b50\u5225\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u6700\u9069\u5316<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6.1 \u907a\u4f1d\u5b50\u578b\u306b\u3088\u308b\u6301\u4e45\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u9069\u5fdc<\/strong><\/h3>\n\n\n\n<p>\u500b\u3005\u306e\u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6226\u7565\u3092\u63a1\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u7387\u7684\u306b\u9178\u7d20\u5229\u7528\u80fd\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ACE II\u578b &amp; ACTN3 XX\u578b<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u9577\u6642\u9593\u306e\u4f4e\u5f37\u5ea6\u6301\u4e45\u904b\u52d5<\/strong>\uff08\u30e9\u30f3\u30cb\u30f3\u30b0\u3001\u30b5\u30a4\u30af\u30ea\u30f3\u30b0\uff09\u3092\u91cd\u8996\u3002<\/li>\n\n\n\n<li><strong>\u6709\u9178\u7d20\u904b\u52d5\uff0b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6d3b\u6027\u5316<\/strong>\uff08HIIT\u3092\u9069\u5ea6\u306b\u53d6\u308a\u5165\u308c\u308b\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>ACE DD\u578b &amp; ACTN3 RR\u578b<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u77ed\u6642\u9593\u306e\u9ad8\u5f37\u5ea6\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\uff08\u30b9\u30d7\u30ea\u30f3\u30c8\u3001\u30a6\u30a7\u30a4\u30c8\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff09\u3002<\/li>\n\n\n\n<li><strong>\u7121\u9178\u7d20\u904b\u52d5\uff0b\u7b4b\u529b\u5f37\u5316<\/strong>\uff08\u7206\u767a\u7684\u306a\u52d5\u4f5c\u3092\u5897\u3084\u3059\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>EPAS1\u9ad8\u767a\u73fe\u578b<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\uff08\u4f4e\u9178\u7d20\u74b0\u5883\u3067\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3067\u6700\u5927\u9178\u7d20\u6442\u53d6\u91cf\u3092\u5411\u4e0a\uff09\u3002<\/li>\n\n\n\n<li><strong>\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\uff08\u9178\u7d20\u4f9b\u7d66\u80fd\u529b\u3092\u935b\u3048\u308b\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6.2 \u6301\u4e45\u529b\u5411\u4e0a\u306e\u305f\u3081\u306e\u88dc\u52a9\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u547c\u5438\u7b4b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\uff1a\u6a2a\u9694\u819c\u3092\u5f37\u5316\u3057\u3001\u80ba\u6d3b\u91cf\u3092\u5411\u4e0a\u3002<\/li>\n\n\n\n<li><strong>\u4f4e\u9178\u7d20\u30de\u30b9\u30af\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\uff1a\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u4ee3\u66ff\u624b\u6bb5\u3068\u3057\u3066\u6d3b\u7528\u53ef\u80fd\u3002<\/li>\n\n\n\n<li><strong>\u4ea4\u4e92\u6e29\u51b7\u6d74\uff08\u30b5\u30a6\u30ca\uff0b\u51b7\u6c34\u6d74\uff09<\/strong>\uff1a\u8840\u6d41\u3092\u4fc3\u9032\u3057\u3001\u56de\u5fa9\u529b\u3092\u5411\u4e0a\u3002<\/li>\n<\/ul>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>7. \u6804\u990a\u3068\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306b\u3088\u308b\u9178\u7d20\u5229\u7528\u306e\u6700\u9069\u5316<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7.1 \u785d\u9178\u5869\u3068\u4e00\u9178\u5316\u7a92\u7d20\uff08NO\uff09<\/strong><\/h3>\n\n\n\n<p>\u9178\u7d20\u5229\u7528\u52b9\u7387\u3092\u9ad8\u3081\u308b\u306b\u306f\u3001\u8840\u6d41\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002\u4e00\u9178\u5316\u7a92\u7d20\uff08NO\uff09\u306f\u8840\u7ba1\u62e1\u5f35\u3092\u4fc3\u3057\u3001\u9178\u7d20\u4f9b\u7d66\u3092\u6539\u5584\u3057\u307e\u3059\u3002<strong>NOS3\u907a\u4f1d\u5b50<\/strong> \u306fNO\u306e\u751f\u6210\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001NOS3\u306e\u767a\u73fe\u304c\u9ad8\u3044\u4eba\u306f\u3001\u904b\u52d5\u6642\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u5411\u4e0a\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-019-45397-5\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>NO\u3092\u5897\u3084\u3059\u98df\u54c1\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d3\u30fc\u30c8\u30eb\u30fc\u30c8\u30b8\u30e5\u30fc\u30b9<\/strong><\/li>\n\n\n\n<li><strong>\u30c0\u30fc\u30af\u30c1\u30e7\u30b3\u30ec\u30fc\u30c8\uff08\u30ab\u30ab\u30aa\u542b\u6709\u738770%\u4ee5\u4e0a\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u30b7\u30c8\u30eb\u30ea\u30f3\uff08\u30b9\u30a4\u30ab\u3001\u30ad\u30e5\u30a6\u30ea\uff09<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7.2 \u30af\u30ec\u30a2\u30c1\u30f3\u3068ATP\u7523\u751f<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/5080812_m-1024x683.jpg\" alt=\"\n\u5869\u30b5\u30d0\u5b9a\u98df\" class=\"wp-image-9733\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/5080812_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/5080812_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/5080812_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/5080812_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/5080812_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30af\u30ec\u30a2\u30c1\u30f3\u306fATP\u518d\u751f\u3092\u52a9\u3051\u3001\u77ac\u767a\u7684\u306a\u30d1\u30ef\u30fc\u3084\u6301\u4e45\u529b\u3092\u5411\u4e0a\u3055\u305b\u307e\u3059\u3002<strong>CKM\u907a\u4f1d\u5b50\uff08\u30af\u30ec\u30a2\u30c1\u30f3\u30ad\u30ca\u30fc\u30bc\uff09<\/strong> \u306e\u30d0\u30ea\u30a8\u30fc\u30b7\u30e7\u30f3\u306b\u3088\u3063\u3066\u3001\u30af\u30ec\u30a2\u30c1\u30f3\u306e\u52b9\u679c\u304c\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6275467\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u30af\u30ec\u30a2\u30c1\u30f3\u3092\u6d3b\u304b\u3059\u65b9\u6cd5\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u524d\u5f8c\u306b\u30af\u30ec\u30a2\u30c1\u30f3\u3092\u6442\u53d6<\/strong>\uff08\u7b4b\u8089\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u518d\u751f\u3092\u30b5\u30dd\u30fc\u30c8\uff09\u3002<\/li>\n\n\n\n<li><strong>\u30af\u30ec\u30a2\u30c1\u30f3\u3068\u70ad\u6c34\u5316\u7269\u3092\u7d44\u307f\u5408\u308f\u305b\u308b<\/strong>\uff08\u5438\u53ce\u7387\u3092\u5411\u4e0a\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7.3 \u9244\u5206\u3068\u9178\u7d20\u8f38\u9001<\/strong><\/h3>\n\n\n\n<p>\u9244\u306f\u9178\u7d20\u3092\u904b\u3076\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u306e\u751f\u6210\u306b\u5fc5\u8981\u4e0d\u53ef\u6b20\u3067\u3001\u9244\u4e0d\u8db3\u306f\u6301\u4e45\u529b\u4f4e\u4e0b\u306e\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002<strong>HFE\u907a\u4f1d\u5b50<\/strong> \u306e\u5909\u7570\u306b\u3088\u3063\u3066\u9244\u306e\u5438\u53ce\u80fd\u529b\u304c\u7570\u306a\u308b\u305f\u3081\u3001\u500b\u5225\u306e\u6442\u53d6\u6226\u7565\u304c\u91cd\u8981\u3067\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-018-25219-x\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u9244\u5206\u3092\u52b9\u679c\u7684\u306b\u6442\u53d6\u3059\u308b\u65b9\u6cd5\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u52d5\u7269\u6027\u30d8\u30e0\u9244\uff08\u8d64\u8eab\u8089\u3001\u30ec\u30d0\u30fc\uff09<\/strong> \u306f\u5438\u53ce\u7387\u304c\u9ad8\u3044\u3002<\/li>\n\n\n\n<li><strong>\u30d3\u30bf\u30df\u30f3C\u3068\u4e00\u7dd2\u306b\u6442\u53d6<\/strong>\uff08\u975e\u30d8\u30e0\u9244\u306e\u5438\u53ce\u3092\u4fc3\u9032\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-c61653b3-7fff-7188-3271-76ca6d741236\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>8. \u907a\u4f1d\u5b50\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6700\u9069\u5316<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8.1 \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u3092\u9ad8\u3081\u308b\u907a\u4f1d\u5b50\u306e\u5f79\u5272<\/strong><\/h3>\n\n\n\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u5de5\u5834\u3068\u3057\u3066\u50cd\u304d\u3001\u9178\u7d20\u3092\u5229\u7528\u3057\u3066ATP\uff08\u30a2\u30c7\u30ce\u30b7\u30f3\u4e09\u30ea\u30f3\u9178\uff09\u3092\u751f\u6210\u3057\u307e\u3059\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306b\u306f <strong>PGC-1\u03b1\uff08PPARGC1A\uff09<\/strong>\u3001<strong>TFAM\uff08\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u8907\u88fd\u56e0\u5b50\uff09<\/strong> \u306a\u3069\u304c\u3042\u308a\u3001\u305d\u308c\u305e\u308c\u304c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5f62\u6210\u3084\u6a5f\u80fd\u7dad\u6301\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PGC-1\u03b1\uff08PPARGC1A\uff09<\/strong>\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u751f\u5408\u6210\u3092\u4fc3\u9032\u3057\u3001\u6301\u4e45\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u3002<\/li>\n\n\n\n<li><strong>TFAM<\/strong>\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u306e\u8907\u88fd\u3092\u8abf\u6574\u3057\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u80fd\u529b\u3092\u9ad8\u3081\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u3068\u3001\u9178\u7d20\u5229\u7528\u52b9\u7387\u304c\u5411\u4e0a\u3057\u3001\u75b2\u52b4\u56de\u5fa9\u304c\u65e9\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/cell-metabolism\/fulltext\/S1550-4131(04)00253-2\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8.2 \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5065\u5eb7\u3092\u4fdd\u3064\u6804\u990a\u7d20<\/strong><\/h3>\n\n\n\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u3092\u6700\u5927\u5316\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u7279\u5b9a\u306e\u6804\u990a\u7d20\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u304c\u52b9\u679c\u7684\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0Q10\uff08CoQ10\uff09<\/strong>\uff1aATP\u7523\u751f\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u3001\u6301\u4e45\u529b\u5411\u4e0a\u306b\u5bc4\u4e0e\u3002<\/li>\n\n\n\n<li><strong>ALA\uff08\u03b1\u30ea\u30dd\u9178\uff09<\/strong>\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u8efd\u6e1b\u3002<\/li>\n\n\n\n<li><strong>\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb<\/strong>\uff08\u30d6\u30c9\u30a6\u3001\u8d64\u30ef\u30a4\u30f3\uff09\uff1aPGC-1\u03b1\u3092\u6d3b\u6027\u5316\u3057\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u4fc3\u9032\u3002<\/li>\n\n\n\n<li><strong>\u30aa\u30e1\u30ac3\u8102\u80aa\u9178<\/strong>\uff08\u30b5\u30fc\u30e2\u30f3\u3001\u30a2\u30de\u30cb\u6cb9\uff09\uff1a\u7d30\u80de\u819c\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3057\u3001\u9178\u7d20\u5229\u7528\u52b9\u7387\u3092\u6539\u5584\u3002<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-c61653b3-7fff-7188-3271-76ca6d741236\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>9. \u9178\u7d20\u5229\u7528\u52b9\u7387\u3068\u907a\u4f1d\u7684\u9069\u5fdc<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9.1 \u907a\u4f1d\u5b50\u3068\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u52b9\u679c<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31839276_m-1024x585.jpg\" alt=\"\n\u8d70\u308b\" class=\"wp-image-9740\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31839276_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31839276_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31839276_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31839276_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31839276_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u6a19\u9ad8\u306e\u9ad8\u3044\u5834\u6240\u3067\u306f\u9178\u7d20\u304c\u8584\u304f\u306a\u308a\u3001\u4f53\u306f\u4f4e\u9178\u7d20\u74b0\u5883\u306b\u9069\u5fdc\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u9069\u5fdc\u306b\u306f <strong>EPAS1\uff08\u4f4e\u9178\u7d20\u8a98\u5c0e\u56e0\u5b502\u03b1\uff09<\/strong> \u306a\u3069\u306e\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>EPAS1\u306e\u5f79\u5272<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4f4e\u9178\u7d20\u74b0\u5883\u306b\u304a\u3044\u3066\u3001\u8d64\u8840\u7403\u306e\u5897\u52a0\u3092\u4fc3\u9032\u3057\u3001\u9178\u7d20\u4f9b\u7d66\u3092\u6539\u5584\u3002<\/li>\n\n\n\n<li>\u30c1\u30d9\u30c3\u30c8\u4eba\u3084\u30a8\u30c1\u30aa\u30d4\u30a2\u306e\u9577\u8ddd\u96e2\u30e9\u30f3\u30ca\u30fc\u306b\u591a\u304f\u898b\u3089\u308c\u308b\u907a\u4f1d\u5b50\u5909\u7570\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306f\u3001EPAS1\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3057\u3001\u4f4e\u9178\u7d20\u4e0b\u3067\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/nature14679\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u6700\u5927\u9650\u6d3b\u7528\u3059\u308b\u65b9\u6cd5\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>2\u9031\u9593\u4ee5\u4e0a\u306e\u6ede\u5728<\/strong>\uff08\u4f53\u304c\u9069\u5fdc\u3059\u308b\u306e\u306b\u6642\u9593\u304c\u304b\u304b\u308b\u305f\u3081\uff09\u3002<\/li>\n\n\n\n<li><strong>\u9244\u5206\u88dc\u7d66<\/strong>\uff08\u8d64\u8840\u7403\u306e\u751f\u6210\u3092\u30b5\u30dd\u30fc\u30c8\uff09\u3002<\/li>\n\n\n\n<li><strong>\u4f4e\u9178\u7d20\u74b0\u5883\u3067\u306e\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\uff08\u9178\u7d20\u4f9b\u7d66\u80fd\u529b\u306e\u5411\u4e0a\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9.2 \u9178\u7d20\u904b\u642c\u80fd\u529b\u3092\u5f37\u5316\u3059\u308b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong><\/h3>\n\n\n\n<p>\u9178\u7d20\u3092\u52b9\u679c\u7684\u306b\u904b\u642c\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u5fc3\u80ba\u6a5f\u80fd\u306e\u5f37\u5316\u304c\u5fc5\u8981\u3067\u3059\u3002<strong>VEGF\uff08\u8840\u7ba1\u5185\u76ae\u6210\u9577\u56e0\u5b50\uff09<\/strong> \u3068\u3044\u3046\u907a\u4f1d\u5b50\u306f\u3001\u65b0\u3057\u3044\u6bdb\u7d30\u8840\u7ba1\u306e\u5f62\u6210\u3092\u4fc3\u9032\u3057\u3001\u9178\u7d20\u4f9b\u7d66\u80fd\u529b\u3092\u9ad8\u3081\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>VEGF\u3092\u6d3b\u6027\u5316\u3059\u308b\u65b9\u6cd5<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6709\u9178\u7d20\u904b\u52d5<\/strong>\uff08\u30e9\u30f3\u30cb\u30f3\u30b0\u3001\u30b5\u30a4\u30af\u30ea\u30f3\u30b0\uff09\u3092\u5b9a\u671f\u7684\u306b\u884c\u3046\u3002<\/li>\n\n\n\n<li><strong>\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff08\u7dd1\u8336\u3001\u30d6\u30eb\u30fc\u30d9\u30ea\u30fc\uff09<\/strong> \u3092\u6442\u53d6\u3057\u3001\u8840\u6d41\u3092\u6539\u5584\u3002<\/li>\n\n\n\n<li><strong>\u9ad8\u5f37\u5ea6\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08HIIT\uff09<\/strong> \u3092\u53d6\u308a\u5165\u308c\u3001\u5fc3\u80ba\u6a5f\u80fd\u3092\u5411\u4e0a\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u306b\u3088\u308a\u3001\u9178\u7d20\u4f9b\u7d66\u80fd\u529b\u3092\u5411\u4e0a\u3055\u305b\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u6210\u679c\u3092\u6700\u5927\u5316\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c61653b3-7fff-7188-3271-76ca6d741236\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>10. \u907a\u4f1d\u5b50\u3068\u7b4b\u8089\u30bf\u30a4\u30d7\u306e\u6700\u9069\u5316<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10.1 \u7b4b\u7e4a\u7dad\u30bf\u30a4\u30d7\u3068\u9178\u7d20\u5229\u7528\u52b9\u7387<\/strong><\/h3>\n\n\n\n<p>\u7b4b\u8089\u306b\u306f\u5927\u304d\u304f\u5206\u3051\u3066 <strong>\u901f\u7b4b\uff08\u767d\u7b4b\uff09<\/strong> \u3068 <strong>\u9045\u7b4b\uff08\u8d64\u7b4b\uff09<\/strong> \u306e2\u7a2e\u985e\u304c\u3042\u308a\u3001\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u512a\u4f4d\u306a\u7b4b\u7e4a\u7dad\u306e\u30bf\u30a4\u30d7\u304c\u6c7a\u307e\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9045\u7b4b\uff08\u6301\u4e45\u529b\u30bf\u30a4\u30d7\uff09<\/strong>\uff1a\u9178\u7d20\u3092\u5229\u7528\u3057\u3001\u9577\u6642\u9593\u306e\u904b\u52d5\u306b\u9069\u5fdc\uff08<strong>ACTN3 XX\u578b<\/strong>\uff09\u3002<\/li>\n\n\n\n<li><strong>\u901f\u7b4b\uff08\u7206\u767a\u7684\u30d1\u30ef\u30fc\u30bf\u30a4\u30d7\uff09<\/strong>\uff1a\u77ac\u767a\u7684\u306a\u52d5\u304d\u306b\u5f37\u3044\uff08<strong>ACTN3 RR\u578b<\/strong>\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<p>ACTN3\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a8\u30fc\u30b7\u30e7\u30f3\u306b\u57fa\u3065\u3044\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6226\u7565\u3092\u63a1\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u52b9\u679c\u7684\u306a\u6301\u4e45\u529b\u5411\u4e0a\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC421889\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10.2 \u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u7b4b\u8089\u5f37\u5316\u6cd5<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6301\u4e45\u7cfb\uff08ACTN3 XX\u578b\uff09<\/strong> \u2192 <strong>\u9577\u6642\u9593\u306e\u4f4e\u5f37\u5ea6\u6301\u4e45\u904b\u52d5<\/strong>\uff08\u30de\u30e9\u30bd\u30f3\u3001\u30c8\u30e9\u30a4\u30a2\u30b9\u30ed\u30f3\uff09\u3002<\/li>\n\n\n\n<li><strong>\u30d1\u30ef\u30fc\u7cfb\uff08ACTN3 RR\u578b\uff09<\/strong> \u2192 <strong>\u77ed\u6642\u9593\u306e\u9ad8\u5f37\u5ea6\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\uff08\u30b9\u30d7\u30ea\u30f3\u30c8\u3001\u30a6\u30a7\u30a4\u30c8\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff09\u3002<\/li>\n\n\n\n<li><strong>\u30d0\u30e9\u30f3\u30b9\u578b\uff08ACTN3 RX\u578b\uff09<\/strong> \u2192 <strong>\u6301\u4e45\u529b\uff0b\u7b4b\u529b\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u578b\u3092\u8003\u616e\u3057\u305f\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u7d44\u3080\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c61653b3-7fff-7188-3271-76ca6d741236\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>11. \u907a\u4f1d\u5b50\u3068\u4ee3\u8b1d\u52b9\u7387<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>11.1 \u907a\u4f1d\u5b50\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u4f9b\u7d66\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/31601077_m-1024x683.jpg\" alt=\"\u4f53\u91cd\u8a08\u306b\u4e57\u308b\u8db3\u5143\u3000\u30c0\u30a4\u30a8\u30c3\u30c8\u30a4\u30e1\u30fc\u30b8\" class=\"wp-image-8355\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31601077_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31601077_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31601077_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31601077_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31601077_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30a8\u30cd\u30eb\u30ae\u30fc\u4f9b\u7d66\u306b\u306f\u3001\u7cd6\u8cea\u30fb\u8102\u8cea\u30fb\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4ee3\u8b1d\u304c\u95a2\u308f\u308a\u307e\u3059\u304c\u3001\u4ee3\u8b1d\u306e\u52b9\u7387\u306f <strong>PPARG<\/strong> \u3084 <strong>FTO<\/strong> \u306a\u3069\u306e\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u6c7a\u307e\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PPARG\u907a\u4f1d\u5b50<\/strong>\uff1a\u8102\u80aa\u71c3\u713c\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u8abf\u7bc0\u3057\u3001\u6301\u4e45\u529b\u5411\u4e0a\u306b\u95a2\u4e0e\u3002<\/li>\n\n\n\n<li><strong>FTO\u907a\u4f1d\u5b50<\/strong>\uff1a\u98df\u6b32\u3084\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u7684\u306b\u8102\u80aa\u71c3\u713c\u304c\u5f97\u610f\u306a\u4eba\u306f\u3001\u4f4e\u70ad\u6c34\u5316\u7269\u30fb\u9ad8\u8102\u80aa\u306e\u98df\u4e8b\uff08\u30b1\u30c8\u30b8\u30a7\u30cb\u30c3\u30af\u30c0\u30a4\u30a8\u30c3\u30c8\uff09\u3092\u8a66\u3059\u3053\u3068\u3067\u3001\u9178\u7d20\u5229\u7528\u52b9\u7387\u3092\u5411\u4e0a\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>11.2 \u4ee3\u8b1d\u3092\u6700\u9069\u5316\u3059\u308b\u6804\u990a\u6226\u7565<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8102\u80aa\u71c3\u713c\u578b\uff08PPARG\u6d3b\u6027\u304c\u9ad8\u3044\uff09<\/strong> \u2192 \u30b1\u30c8\u30b8\u30a7\u30cb\u30c3\u30af\u30c0\u30a4\u30a8\u30c3\u30c8\uff0b\u6709\u9178\u7d20\u904b\u52d5\u3002<\/li>\n\n\n\n<li><strong>\u7cd6\u8cea\u71c3\u713c\u578b\uff08FTO\u30ea\u30b9\u30af\u578b\uff09<\/strong> \u2192 \u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u7cd6\u8cea\u30fb\u30bf\u30f3\u30d1\u30af\u8cea\u6442\u53d6\uff0b\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3002<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-c61653b3-7fff-7188-3271-76ca6d741236\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>12. \u9178\u7d20\u5229\u7528\u3068\u8840\u6db2\u306e\u95a2\u4fc2\uff1a\u907a\u4f1d\u5b50\u306b\u3088\u308b\u5f71\u97ff<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12.1 \u8d64\u8840\u7403\u306e\u5f79\u5272\u3068\u907a\u4f1d\u5b50\u306e\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<p>\u8d64\u8840\u7403\u306f\u3001\u9178\u7d20\u3092\u80ba\u304b\u3089\u5168\u8eab\u306e\u7b4b\u8089\u3078\u3068\u904b\u642c\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u3053\u306e\u8d64\u8840\u7403\u306e\u751f\u6210\u3084\u6a5f\u80fd\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001<strong>EPO\uff08\u30a8\u30ea\u30b9\u30ed\u30dd\u30a8\u30c1\u30f3\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u8d64\u8840\u7403\u306e\u7523\u751f\u3092\u4fc3\u3059\u4e3b\u8981\u306a\u56e0\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>EPO\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u9ad8\u3044\u4eba<\/strong> \u306f\u3001\u901a\u5e38\u3088\u308a\u591a\u304f\u306e\u8d64\u8840\u7403\u3092\u4f5c\u308a\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u3001\u9178\u7d20\u4f9b\u7d66\u80fd\u529b\u304c\u5411\u4e0a\u3059\u308b\u305f\u3081\u3001\u6301\u4e45\u529b\u30b9\u30dd\u30fc\u30c4\u306b\u9069\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>EPO\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u4f4e\u3044\u4eba<\/strong> \u306f\u3001\u8d64\u8840\u7403\u306e\u5897\u52a0\u304c\u8d77\u3053\u308a\u306b\u304f\u304f\u3001\u4f4e\u9178\u7d20\u74b0\u5883\u3067\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u304c\u4f4e\u4e0b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-020-67298-2\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<p>EPO\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3059\u308b\u65b9\u6cd5\u3068\u3057\u3066\u306f\u3001\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3084\u8d64\u8eab\u8089\u30fb\u9244\u5206\u306e\u591a\u3044\u98df\u54c1\u306e\u6442\u53d6\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12.2 \u9244\u4ee3\u8b1d\u3092\u8abf\u6574\u3059\u308bHFE\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p><strong>HFE\u907a\u4f1d\u5b50<\/strong> \u306f\u4f53\u5185\u306e\u9244\u306e\u5438\u53ce\u3092\u8abf\u7bc0\u3057\u3001\u8d64\u8840\u7403\u306e\u751f\u6210\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002HFE\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba\u306f\u3001\u9244\u306e\u5438\u53ce\u7387\u304c\u7570\u306a\u308b\u305f\u3081\u3001\u9069\u5207\u306a\u9244\u5206\u88dc\u7d66\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9244\u306e\u5438\u53ce\u304c\u4f4e\u3044\u30bf\u30a4\u30d7\uff08HFE\u5909\u7570\u578b\uff09<\/strong> \u2192 \u9244\u4e0d\u8db3\u306b\u3088\u308a\u8ca7\u8840\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3002<\/li>\n\n\n\n<li><strong>\u9244\u306e\u5438\u53ce\u304c\u9ad8\u3044\u30bf\u30a4\u30d7\uff08HFE\u6d3b\u6027\u578b\uff09<\/strong> \u2192 \u9244\u306e\u904e\u5270\u84c4\u7a4d\u306b\u6ce8\u610f\u304c\u5fc5\u8981\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u9244\u5206\u3092\u9069\u5207\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u9178\u7d20\u4f9b\u7d66\u80fd\u529b\u3092\u6700\u9069\u5316\u3057\u3001\u6301\u4e45\u529b\u5411\u4e0a\u306b\u3064\u306a\u3052\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC479958\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u9244\u5206\u304c\u8c4a\u5bcc\u306a\u98df\u54c1\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u52d5\u7269\u6027\u30d8\u30e0\u9244\uff1a\u8d64\u8eab\u8089\u3001\u30ec\u30d0\u30fc\u3001\u30ab\u30c4\u30aa<\/li>\n\n\n\n<li>\u690d\u7269\u6027\u975e\u30d8\u30e0\u9244\uff1a\u307b\u3046\u308c\u3093\u8349\u3001\u5927\u8c46\u88fd\u54c1<\/li>\n\n\n\n<li>\u30d3\u30bf\u30df\u30f3C\u3068\u4e00\u7dd2\u306b\u6442\u308b\u3068\u9244\u306e\u5438\u53ce\u7387\u304c\u5411\u4e0a<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-c61653b3-7fff-7188-3271-76ca6d741236\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>13. \u907a\u4f1d\u5b50\u3068\u80ba\u6a5f\u80fd\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/3881826_m-1024x683.jpg\" alt=\"\n\u6df1\u547c\u5438\u3059\u308b\u7537\u6027\" class=\"wp-image-9747\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3881826_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3881826_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3881826_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3881826_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3881826_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>13.1 \u80ba\u6d3b\u91cf\u3092\u6c7a\u3081\u308b\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h3>\n\n\n\n<p>\u9178\u7d20\u5229\u7528\u52b9\u7387\u3092\u9ad8\u3081\u308b\u305f\u3081\u306b\u306f\u3001\u80ba\u304c\u5341\u5206\u306a\u9178\u7d20\u3092\u53d6\u308a\u8fbc\u3081\u308b\u3053\u3068\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u80ba\u6a5f\u80fd\u3092\u8abf\u7bc0\u3059\u308b\u907a\u4f1d\u5b50\u306e\u4e00\u3064\u306b <strong>VEGF\uff08\u8840\u7ba1\u5185\u76ae\u6210\u9577\u56e0\u5b50\uff09<\/strong> \u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>VEGF\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u9ad8\u3044\u4eba<\/strong> \u2192 \u80ba\u306e\u6bdb\u7d30\u8840\u7ba1\u304c\u767a\u9054\u3057\u3001\u9178\u7d20\u4f9b\u7d66\u80fd\u529b\u304c\u5411\u4e0a\u3002<\/li>\n\n\n\n<li><strong>VEGF\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u4f4e\u3044\u4eba<\/strong> \u2192 \u80ba\u306e\u9178\u7d20\u62e1\u6563\u80fd\u529b\u304c\u5236\u9650\u3055\u308c\u3001\u6301\u4e45\u529b\u5411\u4e0a\u304c\u96e3\u3057\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u305f\u3081\u3001VEGF\u306e\u767a\u73fe\u3092\u9ad8\u3081\u308b\u6804\u990a\u7d20\uff08\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3001\u30d3\u30bf\u30df\u30f3C\u3001\u785d\u9178\u5869\u306a\u3069\uff09\u3092\u6442\u53d6\u3057\u3001\u547c\u5438\u7b4b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3046\u3053\u3068\u304c\u52b9\u679c\u7684\u3067\u3059\uff08<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0306987705004741\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>13.2 \u80ba\u6d3b\u91cf\u3092\u5897\u3084\u3059\u305f\u3081\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6a2a\u9694\u819c\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\uff1a\u6df1\u547c\u5438\u3084\u547c\u5438\u7b4b\u30b9\u30c8\u30ec\u30c3\u30c1\u3092\u884c\u3044\u3001\u80ba\u6d3b\u91cf\u3092\u5897\u52a0\u3002<\/li>\n\n\n\n<li><strong>\u4f4e\u9178\u7d20\u30de\u30b9\u30af\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\uff1a\u80ba\u306e\u9178\u7d20\u53d6\u308a\u8fbc\u307f\u80fd\u529b\u3092\u935b\u3048\u3001\u6301\u4e45\u529b\u5411\u4e0a\u306b\u5f79\u7acb\u3064\u3002<\/li>\n\n\n\n<li><strong>\u6709\u9178\u7d20\u904b\u52d5<\/strong>\uff1a\u30e9\u30f3\u30cb\u30f3\u30b0\u3001\u30b9\u30a4\u30df\u30f3\u30b0\u3001\u30b5\u30a4\u30af\u30ea\u30f3\u30b0\u306a\u3069\u306e\u6301\u4e45\u904b\u52d5\u3092\u7d99\u7d9a\u7684\u306b\u884c\u3046\u3002<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-c61653b3-7fff-7188-3271-76ca6d741236\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>14. \u9178\u7d20\u5229\u7528\u52b9\u7387\u3092\u9ad8\u3081\u308b\u6700\u65b0\u306e\u907a\u4f1d\u5b50\u7814\u7a76<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>14.1 \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3068\u30b9\u30dd\u30fc\u30c4\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9<\/strong><\/h3>\n\n\n\n<p>\u8fd1\u5e74\u3001\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\uff08CRISPR\uff09\u3092\u7528\u3044\u305f\u30b9\u30dd\u30fc\u30c4\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u5411\u4e0a\u306e\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001<strong>EPO\u907a\u4f1d\u5b50\u3092\u5f37\u5316<\/strong> \u3059\u308b\u3053\u3068\u3067\u3001\u8d64\u8840\u7403\u306e\u7523\u751f\u3092\u5897\u3084\u3057\u3001\u6301\u4e45\u529b\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>PGC-1\u03b1\u306e\u6d3b\u6027\u5316<\/strong> \u306b\u3088\u308a\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u751f\u6210\u3092\u4fc3\u9032\u3057\u3001\u9178\u7d20\u5229\u7528\u52b9\u7387\u3092\u5411\u4e0a\u3055\u305b\u308b\u8a66\u307f\u3082\u884c\u308f\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/cell-metabolism\/fulltext\/S1550-4131(04)00253-2\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>14.2 \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u6700\u9069\u5316\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong><\/h3>\n\n\n\n<p>\u73fe\u5728\u3001\u907a\u4f1d\u5b50\u89e3\u6790\u30b5\u30fc\u30d3\u30b9\u304c\u9032\u5316\u3057\u3001\u500b\u4eba\u306e\u907a\u4f1d\u7684\u7279\u5fb4\u306b\u57fa\u3065\u3044\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u63d0\u4f9b\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u5206\u304b\u308b\u60c5\u5831\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6700\u5927\u9178\u7d20\u6442\u53d6\u91cf\uff08VO\u2082max\uff09\u306e\u4f38\u3073\u3084\u3059\u3055<\/li>\n\n\n\n<li>\u6301\u4e45\u529b\u5411\u4e0a\u306e\u305f\u3081\u306b\u5fc5\u8981\u306a\u6804\u990a\u7d20<\/li>\n\n\n\n<li>\u9178\u7d20\u4f9b\u7d66\u3092\u9ad8\u3081\u308b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u7a2e\u985e<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u3046\u3057\u305f\u6280\u8853\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u5b9f\u73fe\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c61653b3-7fff-7188-3271-76ca6d741236\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>15. \u907a\u4f1d\u5b50\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>15.1 \u8102\u8cea\u30fb\u7cd6\u8cea\u4ee3\u8b1d\u3068\u6301\u4e45\u529b<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"768\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/2237993_m-1024x768.jpg\" alt=\"\n\u30a2\u30fc\u30e2\u30f3\u30c9\u3068\u30b9\u30d7\u30fc\u30f3\" class=\"wp-image-9754\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/2237993_m-1024x768.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/2237993_m-300x225.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/2237993_m-768x576.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/2237993_m-1536x1152.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/2237993_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30a8\u30cd\u30eb\u30ae\u30fc\u4f9b\u7d66\u306e\u4ed5\u7d44\u307f\u306f <strong>PPARG\uff08\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u30ac\u30f3\u30de\uff09<\/strong> \u3084 <strong>FTO\uff08\u8102\u80aa\u91cf\u3068\u80a5\u6e80\u95a2\u9023\u907a\u4f1d\u5b50\uff09<\/strong> \u306a\u3069\u306e\u907a\u4f1d\u5b50\u306b\u5f71\u97ff\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PPARG\u907a\u4f1d\u5b50\u304c\u6d3b\u6027\u5316\u3057\u3066\u3044\u308b\u4eba<\/strong> \u306f\u3001\u8102\u8cea\u4ee3\u8b1d\u304c\u512a\u308c\u3001\u9577\u6642\u9593\u306e\u6301\u4e45\u904b\u52d5\u306b\u9069\u3057\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>FTO\u907a\u4f1d\u5b50\u304c\u5909\u7570\u3057\u3066\u3044\u308b\u4eba<\/strong> \u306f\u3001\u8102\u80aa\u84c4\u7a4d\u306e\u30ea\u30b9\u30af\u304c\u3042\u308a\u3001\u9069\u5207\u306a\u98df\u4e8b\u7ba1\u7406\u304c\u5fc5\u8981\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u8102\u80aa\u71c3\u713c\u3092\u4fc3\u9032\u3059\u308b\u65b9\u6cd5\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30b1\u30c8\u30b8\u30a7\u30cb\u30c3\u30af\u30c0\u30a4\u30a8\u30c3\u30c8<\/strong>\uff08\u4f4e\u70ad\u6c34\u5316\u7269\uff0b\u9ad8\u8102\u80aa\u98df\uff09<\/li>\n\n\n\n<li><strong>\u30a4\u30f3\u30bf\u30fc\u30df\u30c3\u30c6\u30f3\u30c8\u30d5\u30a1\u30b9\u30c6\u30a3\u30f3\u30b0\uff08\u65ad\u98df\uff09<\/strong> \u306b\u3088\u308b\u4ee3\u8b1d\u4fc3\u9032<\/li>\n\n\n\n<li><strong>MCT\u30aa\u30a4\u30eb\uff08\u4e2d\u9396\u8102\u80aa\u9178\uff09\u306e\u6442\u53d6<\/strong> \u306b\u3088\u308b\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u306e\u5411\u4e0a<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>15.2 \u7b4b\u8089\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4f9b\u7d66\u3068\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u6301\u4e45\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u306b\u306f\u3001\u7b4b\u8089\u304c\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u52b9\u7387\u3088\u304f\u5229\u7528\u3067\u304d\u308b\u3053\u3068\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002<strong>CKM\u907a\u4f1d\u5b50\uff08\u30af\u30ec\u30a2\u30c1\u30f3\u30ad\u30ca\u30fc\u30bc\uff09<\/strong> \u306f\u3001\u7b4b\u8089\u306eATP\u518d\u751f\u80fd\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CKM\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u4eba<\/strong> \u306f\u3001\u30af\u30ec\u30a2\u30c1\u30f3\u88dc\u7d66\u306b\u3088\u308a\u7b4b\u529b\u3068\u6301\u4e45\u529b\u306e\u4e21\u65b9\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u53ef\u80fd\u3002<\/li>\n\n\n\n<li><strong>CKM\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u4f4e\u3044\u4eba<\/strong> \u306f\u3001\u7b4b\u8089\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u88dc\u7d66\u304c\u9045\u308c\u3084\u3059\u304f\u3001\u9069\u5207\u306a\u6804\u990a\u6442\u53d6\u304c\u91cd\u8981\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u30af\u30ec\u30a2\u30c1\u30f3\u3092\u6d3b\u7528\u3057\u305f\u6301\u4e45\u529b\u5411\u4e0a\u6cd5\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u524d\u5f8c\u306b\u30af\u30ec\u30a2\u30c1\u30f3\u6442\u53d6<\/strong>\uff08\u7b4b\u8089\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u518d\u751f\u3092\u30b5\u30dd\u30fc\u30c8\uff09\u3002<\/li>\n\n\n\n<li><strong>\u30af\u30ec\u30a2\u30c1\u30f3\uff0b\u70ad\u6c34\u5316\u7269\u306e\u4f75\u7528<\/strong> \u306b\u3088\u308a\u5438\u53ce\u7387\u3092\u6700\u5927\u5316\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u3068\u9178\u7d20\u5229\u7528\u52b9\u7387\u306e\u95a2\u4fc2\u3092\u7406\u89e3\u3057\u3001\u500b\u3005\u306e\u907a\u4f1d\u7684\u7279\u6027\u306b\u57fa\u3065\u3044\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3068\u6804\u990a\u6226\u7565\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u3001\u6301\u4e45\u529b\u3068\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3092\u6700\u5927\u9650\u306b\u5f15\u304d\u51fa\u3059\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c61653b3-7fff-7188-3271-76ca6d741236\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<p><strong>\u307e\u3068\u3081<\/strong><\/p>\n\n\n\n<p>\u9178\u7d20\u5229\u7528\u52b9\u7387\u306f\u6301\u4e45\u529b\u3084\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306b\u76f4\u7d50\u3057\u3001<strong>ACE<\/strong>\u3001<strong>ACTN3<\/strong>\u3001<strong>EPAS1<\/strong> \u306a\u3069\u306e\u907a\u4f1d\u5b50\u304c\u9178\u7d20\u4f9b\u7d66\u3084\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<strong>EPO<\/strong> \u3084 <strong>HFE<\/strong> \u306f\u8d64\u8840\u7403\u306e\u7523\u751f\u3084\u9244\u4ee3\u8b1d\u3092\u8abf\u7bc0\u3057\u3001\u6301\u4e45\u529b\u5411\u4e0a\u306b\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u500b\u3005\u306e\u907a\u4f1d\u7684\u7279\u6027\u306b\u57fa\u3065\u304d\u3001<strong>\u6709\u9178\u7d20\u904b\u52d5\u30fb\u9ad8\u5730\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30fb\u9244\u5206\u88dc\u7d66\u30fb\u30af\u30ec\u30a2\u30c1\u30f3\u6442\u53d6<\/strong> \u306a\u3069\u3092\u6700\u9069\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u9178\u7d20\u5229\u7528\u52b9\u7387\u3092\u9ad8\u3081\u3001\u6700\u5927\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u52b9\u679c\u3092\u5f15\u304d\u51fa\u3059\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u9178\u7d20\u5229\u7528\u52b9\u7387\u306f\u30b9\u30dd\u30fc\u30c4\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3084\u6301\u4e45\u529b\u3092\u6c7a\u5b9a\u3059\u308b\u91cd\u8981\u306a\u8981\u56e0\u3067\u3059\u3002\u9178\u7d20\u3092\u52b9\u7387\u3088\u304f\u7b4b\u8089\u306b\u4f9b\u7d66\u3057\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u3057\u3066\u5229\u7528\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u5bc6\u63a5\u306b\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u9178\u7d20\u306e\u8f38\u9001\u3084\u4ee3\u8b1d\u306b [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":9712,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9711","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/9711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=9711"}],"version-history":[{"count":1,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/9711\/revisions"}],"predecessor-version":[{"id":9761,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/9711\/revisions\/9761"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/9712"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=9711"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=9711"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=9711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}