{"id":9762,"date":"2025-03-12T04:34:06","date_gmt":"2025-03-12T04:34:06","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=9762"},"modified":"2025-03-12T04:34:07","modified_gmt":"2025-03-12T04:34:07","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e7%97%85%e6%b0%97%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e4%ba%88%e6%b8%ac%ef%bc%9a%e5%8c%bb%e7%99%82%e3%81%ae%e6%96%b0%e3%81%9f%e3%81%aa%e6%8c%91%e6%88%a6","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e7%97%85%e6%b0%97%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e4%ba%88%e6%b8%ac%ef%bc%9a%e5%8c%bb%e7%99%82%e3%81%ae%e6%96%b0%e3%81%9f%e3%81%aa%e6%8c%91%e6%88%a6\/","title":{"rendered":"\u907a\u4f1d\u5b50\u3068\u75c5\u6c17\u30ea\u30b9\u30af\u306e\u4e88\u6e2c\uff1a\u533b\u7642\u306e\u65b0\u305f\u306a\u6311\u6226"},"content":{"rendered":"\n<p>\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u75c5\u6c17\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4e8b\u524d\u306b\u4e88\u6e2c\u3057\u3001\u500b\u5225\u5316\u533b\u7642\u3092\u5b9f\u73fe\u3059\u308b\u53d6\u308a\u7d44\u307f\u304c\u52a0\u901f\u3057\u3066\u3044\u307e\u3059\u3002<strong>\u30b2\u30ce\u30e0\u89e3\u6790<\/strong> \u3084 <strong>\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30b9\u30b3\u30a2\uff08Polygenic Risk Score\uff1aPRS\uff09<\/strong> \u3092\u6d3b\u7528\u3057\u305f\u4e88\u6e2c\u6280\u8853\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u304c\u3093\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306a\u3069\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3059\u308b\u4e0a\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u8a18\u4e8b\u3067\u306f\u3001\u907a\u4f1d\u5b50\u3068\u75c5\u6c17\u30ea\u30b9\u30af\u306e\u95a2\u9023\u6027\u3092\u89e3\u660e\u3057\u3001\u6700\u65b0\u306e\u7814\u7a76\u6210\u679c\u3092\u57fa\u306b\u3057\u305f\u4e88\u6e2c\u6280\u8853\u3001\u7cbe\u5ea6\u306e\u8ab2\u984c\u3001\u5b9f\u969b\u306e\u533b\u7642\u3078\u306e\u5fdc\u7528\u65b9\u6cd5\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-e91b8edc-7fff-2de1-15b9-4c12a5bd3e7e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>1. \u907a\u4f1d\u5b50\u3068\u75c5\u6c17\u30ea\u30b9\u30af\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1.1 \u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u306e\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<p>\u75c5\u6c17\u306e\u767a\u75c7\u306b\u306f\u3001<strong>\u907a\u4f1d\u7684\u8981\u56e0<\/strong> \u3068 <strong>\u74b0\u5883\u8981\u56e0<\/strong> \u306e\u76f8\u4e92\u4f5c\u7528\u304c\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30e2\u30ce\u30b8\u30a7\u30cb\u30c3\u30af\u75be\u60a3\uff08\u5358\u4e00\u907a\u4f1d\u5b50\u75be\u60a3\uff09<\/strong>\uff1a\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u76f4\u63a5\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u308b\uff08\u4f8b\uff1a\u56a2\u80de\u6027\u7dda\u7dad\u75c7\u3001\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\uff09\u3002<\/li>\n\n\n\n<li><strong>\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u75be\u60a3\uff08\u591a\u56e0\u5b50\u6027\u75be\u60a3\uff09<\/strong>\uff1a\u8907\u6570\u306e\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3001\u74b0\u5883\u8981\u56e0\u3082\u5f71\u97ff\u3092\u53ca\u307c\u3059\uff08\u4f8b\uff1a\u7cd6\u5c3f\u75c5\u3001\u5fc3\u75be\u60a3\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u8fd1\u5e74\u306e\u30b2\u30ce\u30e0\u7814\u7a76\u3067\u306f\u3001<strong>GWAS\uff08Genome-Wide Association Study\uff09<\/strong> \u306b\u3088\u3063\u3066\u3001\u7279\u5b9a\u306e\u75c5\u6c17\u3068\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u5909\u7570\u304c\u591a\u6570\u767a\u898b\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41586-019-1411-9\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1.2 \u907a\u4f1d\u5b50\u5909\u7570\u3068\u75be\u60a3\u306e\u95a2\u9023\u6027<\/strong><\/h3>\n\n\n\n<p>\u75be\u60a3\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u4ee3\u8868\u7684\u306a\u907a\u4f1d\u5b50\u5909\u7570\u306e\u4f8b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>BRCA1\/BRCA2<\/strong>\uff1a\u4e73\u304c\u3093\u30fb\u5375\u5de3\u304c\u3093\u306e\u30ea\u30b9\u30af\u3092\u5927\u5e45\u306b\u4e0a\u6607\uff08<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJM199410203311601\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>APOE \u03b54<\/strong>\uff1a\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u5897\u52a0\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5763479\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>TP53<\/strong>\uff1a\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u30ea\u30fb\u30d5\u30e9\u30a6\u30e1\u30cb\u75c7\u5019\u7fa4\u3092\u5f15\u304d\u8d77\u3053\u3059\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5726115\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>HLA\u907a\u4f1d\u5b50<\/strong>\uff1a\u81ea\u5df1\u514d\u75ab\u75be\u60a3\uff08\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3001\u591a\u767a\u6027\u786c\u5316\u75c7\u306a\u3069\uff09\u306e\u30ea\u30b9\u30af\u3092\u6c7a\u5b9a\uff08<a href=\"https:\/\/www.nature.com\/articles\/nature12940\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u75be\u60a3\u306e\u4e88\u9632\u3084\u65e9\u671f\u4ecb\u5165\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-e91b8edc-7fff-2de1-15b9-4c12a5bd3e7e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. \u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30b9\u30b3\u30a2\uff08PRS\uff09\u306b\u3088\u308b\u75c5\u6c17\u30ea\u30b9\u30af\u306e\u8a55\u4fa1<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2.1 PRS\u3068\u306f\u4f55\u304b\uff1f<\/strong><\/h3>\n\n\n\n<p><strong>\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30b9\u30b3\u30a2\uff08PRS\uff09<\/strong> \u306f\u3001\u8907\u6570\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u7d71\u5408\u3057\u3001\u75be\u60a3\u30ea\u30b9\u30af\u3092\u6570\u5024\u5316\u3059\u308b\u624b\u6cd5\u3067\u3059\u3002\u500b\u4eba\u306e\u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3057\u3001\u75be\u60a3\u767a\u75c7\u306e\u53ef\u80fd\u6027\u3092\u4e88\u6e2c\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8PRS\u30b9\u30b3\u30a2<\/strong> \u2192 \u75c5\u6c17\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044<\/li>\n\n\n\n<li><strong>\u4f4ePRS\u30b9\u30b3\u30a2<\/strong> \u2192 \u75c5\u6c17\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u3044<\/li>\n<\/ul>\n\n\n\n<p>GWAS\u30c7\u30fc\u30bf\u3092\u57fa\u306b\u69cb\u7bc9\u3055\u308c\u3001\u591a\u304f\u306e\u75c5\u6c17\u306b\u5bfe\u3059\u308b\u30ea\u30b9\u30af\u8a55\u4fa1\u304c\u53ef\u80fd\u3068\u306a\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41588-018-0183-z\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2.2 PRS\u306e\u9069\u7528\u4f8b<\/strong><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u5fc3\u8840\u7ba1\u75be\u60a3<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u95a2\u9023\u907a\u4f1d\u5b50\uff08PCSK9\u3001LDLR\uff09\u3092\u542b\u3080PRS\u3067\u5fc3\u75be\u60a3\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3002<\/li>\n\n\n\n<li>\u9ad8\u30ea\u30b9\u30af\u306e\u4eba\u306f\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3084\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u3092\u63a8\u5968\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41591-018-0105-2\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>2\u578b\u7cd6\u5c3f\u75c5<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>TCF7L2\u3001SLC30A8 \u306a\u3069\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u7d44\u307f\u5408\u308f\u305b\u3001\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3002<\/li>\n\n\n\n<li>\u4e88\u6e2c\u7cbe\u5ea6\u5411\u4e0a\u306b\u3088\u308a\u3001\u98df\u4e8b\u7642\u6cd5\u3084\u904b\u52d5\u6307\u5c0e\u3092\u65e9\u671f\u306b\u9069\u7528\uff08<a href=\"https:\/\/www.nature.com\/articles\/ng.2918\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>APOE \u03b54\u907a\u4f1d\u5b50\u3092\u542b\u3080PRS\u304c\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u7cbe\u5ea6\u3067\u4e88\u6e2c\u3002<\/li>\n\n\n\n<li>\u65e9\u671f\u8a3a\u65ad\u3068\u4e88\u9632\u7b56\uff08\u904b\u52d5\u30fb\u98df\u4e8b\u30fb\u8a8d\u77e5\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff09\u3092\u63a8\u5968\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41588-019-0406-6\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n\n<p><span id=\"docs-internal-guid-e91b8edc-7fff-2de1-15b9-4c12a5bd3e7e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u907a\u4f1d\u5b50\u4e88\u6e2c\u306e\u8ab2\u984c\u3068\u533b\u7642\u5fdc\u7528<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-1024x683.jpg\" alt=\"\n\u30bf\u30d6\u30ec\u30c3\u30c8\u3092\u64cd\u4f5c\u3059\u308b\u7537\u6027\u533b\u5e2b\" class=\"wp-image-9770\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3.1 \u7cbe\u5ea6\u306e\u9650\u754c\u3068\u74b0\u5883\u8981\u56e0<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u306e\u307f\u3067\u75c5\u6c17\u306e\u30ea\u30b9\u30af\u3092\u5b8c\u5168\u306b\u4e88\u6e2c\u3059\u308b\u3053\u3068\u306f\u56f0\u96e3\u3067\u3059\u3002\u74b0\u5883\u8981\u56e0\uff08\u98df\u4e8b\u3001\u904b\u52d5\u3001\u30b9\u30c8\u30ec\u30b9\u3001\u793e\u4f1a\u7d4c\u6e08\u72b6\u6cc1\uff09\u3082\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u305f\u3081\u3001\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3068\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u60c5\u5831\u3092\u7d71\u5408\u3057\u305f\u4e88\u6e2c\u30e2\u30c7\u30eb\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3.2 \u502b\u7406\u7684\u8ab2\u984c\u3068\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u4fdd\u8b77<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u60c5\u5831\u306e\u8aa4\u7528\u30ea\u30b9\u30af<\/strong>\uff1a\u751f\u547d\u4fdd\u967a\u3084\u96c7\u7528\u3078\u306e\u5f71\u97ff\u3092\u61f8\u5ff5\u3002<\/li>\n\n\n\n<li><strong>\u30c7\u30fc\u30bf\u306e\u5b89\u5168\u7ba1\u7406<\/strong>\uff1aGDPR\uff08EU\u4e00\u822c\u30c7\u30fc\u30bf\u4fdd\u8b77\u898f\u5247\uff09\u3084HIPAA\uff08\u7c73\u56fd\u533b\u7642\u60c5\u5831\u4fdd\u8b77\u6cd5\uff09\u306b\u3088\u308b\u898f\u5236\u304c\u5f37\u5316\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41467-020-17474-3\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>\u5fc3\u7406\u7684\u5f71\u97ff<\/strong>\uff1a\u75c5\u6c17\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u7d50\u679c\u3092\u53d7\u3051\u305f\u60a3\u8005\u3078\u306e\u9069\u5207\u306a\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u304c\u5fc5\u8981\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3.3 \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u666e\u53ca\u3068\u500b\u5225\u5316\u533b\u7642\u306e\u9032\u5c55<\/strong><\/h3>\n\n\n\n<p>\u8fd1\u5e74\u3001<strong>DTC\uff08Direct-to-Consumer\uff09\u907a\u4f1d\u5b50\u691c\u67fb<\/strong> \u306e\u666e\u53ca\u306b\u3088\u308a\u3001\u500b\u4eba\u304c\u81ea\u5206\u306e\u75c5\u6c17\u30ea\u30b9\u30af\u3092\u628a\u63e1\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u500b\u5225\u5316\u533b\u7642\uff08Precision Medicine\uff09\u304c\u52a0\u901f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u751f\u6d3b\u7fd2\u6163\u306e\u500b\u5225\u6700\u9069\u5316<\/strong>\uff08\u98df\u4e8b\u30fb\u904b\u52d5\u30fb\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u9078\u629e\uff09\u3002<\/li>\n\n\n\n<li><strong>\u500b\u5225\u5316\u85ac\u5264\u6cbb\u7642<\/strong>\uff08\u85ac\u306e\u4ee3\u8b1d\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u3001\u526f\u4f5c\u7528\u3092\u56de\u907f\uff09\u3002<\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306e\u5145\u5b9f<\/strong>\uff08\u907a\u4f1d\u30ea\u30b9\u30af\u306b\u57fa\u3065\u3044\u305f\u533b\u7642\u652f\u63f4\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u3068\u75c5\u6c17\u30ea\u30b9\u30af\u306e\u4e88\u6e2c\u6280\u8853\u306f\u3001\u4e88\u9632\u533b\u5b66\u3084\u500b\u5225\u5316\u533b\u7642\u306e\u5206\u91ce\u3067\u5927\u304d\u306a\u9032\u5c55\u3092\u9042\u3052\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3001\u3055\u3089\u306a\u308b\u7cbe\u5ea6\u5411\u4e0a\u3068\u502b\u7406\u7684\u8ab2\u984c\u306e\u89e3\u6c7a\u304c\u6c42\u3081\u3089\u308c\u308b\u4e2d\u3001\u533b\u7642\u73fe\u5834\u3067\u306e\u6d3b\u7528\u304c\u4e00\u5c64\u671f\u5f85\u3055\u308c\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-e91b8edc-7fff-2de1-15b9-4c12a5bd3e7e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>4. \u907a\u4f1d\u5b50\u3068\u304c\u3093\u30ea\u30b9\u30af\u306e\u4e88\u6e2c<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4.1 \u907a\u4f1d\u5b50\u5909\u7570\u3068\u304c\u3093\u306e\u95a2\u9023\u6027<\/strong><\/h3>\n\n\n\n<p>\u304c\u3093\u306f\u3001\u7d30\u80de\u306e\u907a\u4f1d\u5b50\u5909\u7570\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u75c5\u6c17\u3067\u3059\u3002<strong>BRCA1\/BRCA2<\/strong> \u3084 <strong>TP53<\/strong> \u306a\u3069\u306e\u816b\u760d\u6291\u5236\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u304c\u3093\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u5927\u5e45\u306b\u9ad8\u3081\u307e\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u3067\u3001\u6a19\u6e96\u7684\u306a\u5065\u5eb7\u8a3a\u65ad\u3088\u308a\u3082\u65e9\u3044\u6bb5\u968e\u3067\u30ea\u30b9\u30af\u8a55\u4fa1\u3092\u884c\u3044\u3001\u4e88\u9632\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/ng.2982\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u4ee3\u8868\u7684\u306a\u304c\u3093\u95a2\u9023\u907a\u4f1d\u5b50\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>BRCA1\/BRCA2<\/strong>\uff08\u4e73\u304c\u3093\u30fb\u5375\u5de3\u304c\u3093\uff09<\/li>\n\n\n\n<li><strong>TP53<\/strong>\uff08\u591a\u6570\u306e\u304c\u3093\u7a2e\uff09<\/li>\n\n\n\n<li><strong>MLH1\/MSH2<\/strong>\uff08\u5927\u8178\u304c\u3093\uff09<\/li>\n\n\n\n<li><strong>EGFR<\/strong>\uff08\u80ba\u304c\u3093\uff09<\/li>\n\n\n\n<li><strong>KRAS<\/strong>\uff08\u81b5\u304c\u3093\u3001\u5927\u8178\u304c\u3093\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u691c\u67fb\u3059\u308b\u3053\u3068\u3067\u3001\u9ad8\u30ea\u30b9\u30af\u7fa4\u3092\u7279\u5b9a\u3057\u3001\u500b\u5225\u5316\u533b\u7642\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4.2 \u4e88\u9632\u7684\u6cbb\u7642\u3068\u500b\u5225\u5316\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/31380532_m-1024x585.jpg\" alt=\"\u4ecb\u8b77\u65bd\u8a2d\u3067\u66ae\u3089\u3059\u9ad8\u9f62\u8005\u5973\u6027\u3068\u533b\u5e2b\" class=\"wp-image-8673\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31380532_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31380532_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31380532_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31380532_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31380532_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u57fa\u306b\u3001\u7279\u5b9a\u306e\u304c\u3093\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3068\u5224\u65ad\u3055\u308c\u305f\u5834\u5408\u3001\u4e88\u9632\u7684\u306a\u533b\u7642\u63aa\u7f6e\u304c\u691c\u8a0e\u3055\u308c\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001BRCA1\/BRCA2\u5909\u7570\u3092\u6301\u3064\u5973\u6027\u306f\u3001\u4e88\u9632\u7684\u4e73\u623f\u5207\u9664\uff08\u30ea\u30b9\u30af\u4f4e\u6e1b\u624b\u8853\uff09\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\uff08<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJM199410203311601\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u7d50\u679c\u306b\u57fa\u3065\u304d\u3001<strong>\u5f93\u6765\u306e\u304c\u3093\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3088\u308a\u3082\u65e9\u671f\u306e\u6bb5\u968e\u3067\u691c\u67fb\u3092\u958b\u59cb<\/strong> \u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5927\u8178\u304c\u3093\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u5834\u5408<\/strong> \u2192 40\u6b73\u672a\u6e80\u3067\u306e\u5927\u8178\u5185\u8996\u93e1\u691c\u67fb\u306e\u63a8\u5968<\/li>\n\n\n\n<li><strong>\u4e73\u304c\u3093\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u5834\u5408<\/strong> \u2192 30\u4ee3\u304b\u3089\u306e\u5e741\u56de\u306e\u30de\u30f3\u30e2\u30b0\u30e9\u30d5\u30a3\u30fc\u30fbMRI\u691c\u67fb<\/li>\n\n\n\n<li><strong>\u524d\u7acb\u817a\u304c\u3093\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u5834\u5408<\/strong> \u2192 PSA\u691c\u67fb\u306e\u983b\u5ea6\u3092\u5897\u52a0<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u6226\u7565\u306f\u3001\u65e9\u671f\u767a\u898b\u3068\u4e88\u9632\u306b\u5927\u304d\u304f\u8ca2\u732e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-e91b8edc-7fff-2de1-15b9-4c12a5bd3e7e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>5. \u907a\u4f1d\u5b50\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u4e88\u6e2c<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5.1 \u907a\u4f1d\u5b50\u3068\u52d5\u8108\u786c\u5316\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u5fc3\u8840\u7ba1\u75be\u60a3\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u751f\u6d3b\u7fd2\u6163\u306e\u5f71\u97ff\u3092\u53d7\u3051\u308b\u75be\u60a3\u306e\u4e00\u3064\u3067\u3059\u3002LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308b <strong>PCSK9<\/strong> \u3084 <strong>LDLR<\/strong> \u306e\u5909\u7570\u306f\u3001\u52d5\u8108\u786c\u5316\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41591-018-0105-2\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PCSK9\u907a\u4f1d\u5b50\u5909\u7570<\/strong> \u2192 LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u8abf\u6574\u4e0d\u5168\u306b\u3088\u308b\u9ad8\u8102\u8840\u75c7<\/li>\n\n\n\n<li><strong>LDLR\u907a\u4f1d\u5b50\u5909\u7570<\/strong> \u2192 \u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306e\u539f\u56e0<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5.2 \u907a\u4f1d\u5b50\u3092\u57fa\u306b\u3057\u305f\u500b\u5225\u5316\u6cbb\u7642<\/strong><\/h3>\n\n\n\n<p>\u9ad8\u30ea\u30b9\u30af\u306e\u4eba\u306b\u306f\u3001<strong>\u30b9\u30bf\u30c1\u30f3\u3084PCSK9\u963b\u5bb3\u85ac<\/strong> \u3092\u65e9\u671f\u304b\u3089\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u5fc3\u75be\u60a3\u306e\u767a\u75c7\u3092\u4e88\u9632\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>\u8840\u6813\u30ea\u30b9\u30af\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\uff08F5\u3001F2\uff09<\/strong> \u3092\u6301\u3064\u4eba\u306f\u3001\u8840\u6813\u75c7\u306e\u4e88\u9632\u306e\u305f\u3081\u306b <strong>\u6297\u51dd\u56fa\u85ac\uff08\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u3001DOAC\uff09<\/strong> \u306e\u4f7f\u7528\u304c\u63a8\u5968\u3055\u308c\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1802905\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u500b\u5225\u5316\u6cbb\u7642\u306e\u4f8b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PCSK9\u963b\u5bb3\u85ac<\/strong>\uff08LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5927\u5e45\u306a\u4f4e\u4e0b\uff09<\/li>\n\n\n\n<li><strong>\u6297\u51dd\u56fa\u85ac<\/strong>\uff08\u8840\u6813\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba\u5411\u3051\uff09<\/li>\n\n\n\n<li><strong>\u03b2\u906e\u65ad\u85ac<\/strong>\uff08\u9ad8\u8840\u5727\u30ea\u30b9\u30af\u306e\u3042\u308b\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u3063\u3066\u3001\u3053\u3046\u3057\u305f\u6cbb\u7642\u65b9\u91dd\u3092\u500b\u3005\u306e\u30ea\u30b9\u30af\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306b\u5408\u308f\u305b\u3066\u8abf\u6574\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>6. \u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u907a\u4f1d\u5b50\u4e88\u6e2c<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/26751058_m-1024x683.jpg\" alt=\"\u8eca\u6905\u5b50\u306b\u5ea7\u308b\u7537\u6027\u3068\u4ecb\u52a9\u8005\" class=\"wp-image-8329\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/26751058_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/26751058_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/26751058_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/26751058_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/26751058_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6.1 \u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u306b\u306f\u3001<strong>APOE \u03b54<\/strong> \u3068\u3044\u3046\u907a\u4f1d\u5b50\u5909\u7570\u304c\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<strong>APOE \u03b54\u30921\u30b3\u30d4\u30fc\u6301\u3064\u4eba<\/strong> \u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u7d043\u500d\u306b\u306a\u308a\u3001<strong>2\u30b3\u30d4\u30fc\u6301\u3064\u4eba<\/strong> \u306f\u767a\u75c7\u30ea\u30b9\u30af\u304c\u7d0412\u500d\u306b\u4e0a\u6607\u3059\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41588-019-0406-6\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>APOE\u907a\u4f1d\u5b50\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u03b52\/\u03b52\u578b<\/strong> \u2192 \u4f4e\u30ea\u30b9\u30af<\/li>\n\n\n\n<li><strong>\u03b53\/\u03b53\u578b<\/strong> \u2192 \u6a19\u6e96\u30ea\u30b9\u30af<\/li>\n\n\n\n<li><strong>\u03b53\/\u03b54\u578b<\/strong> \u2192 \u30ea\u30b9\u30af\u4e0a\u6607<\/li>\n\n\n\n<li><strong>\u03b54\/\u03b54\u578b<\/strong> \u2192 \u9ad8\u30ea\u30b9\u30af<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u60c5\u5831\u3092\u57fa\u306b\u3001\u98df\u4e8b\u3084\u904b\u52d5\u3001\u8a8d\u77e5\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u5f37\u5316\u3092\u65e9\u671f\u304b\u3089\u884c\u3046\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6.2 \u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af<\/strong><\/h3>\n\n\n\n<p>\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u767a\u75c7\u306b\u306f <strong>LRRK2\u3001SNCA\u3001GBA<\/strong> \u306a\u3069\u306e\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b <strong>GBA\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong> \u3092\u6301\u3064\u4eba\u306f\u3001\u901a\u5e38\u306e2\u500d\u4ee5\u4e0a\u306e\u30ea\u30b9\u30af\u3092\u6301\u3064\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/ng.3525\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u4e88\u9632\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6297\u708e\u75c7\u98df\u54c1\uff08\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3001\u30aa\u30e1\u30ac3\uff09\u306e\u6442\u53d6<\/li>\n\n\n\n<li>\u6709\u9178\u7d20\u904b\u52d5\uff08\u8133\u306e\u795e\u7d4c\u53ef\u5851\u6027\u3092\u9ad8\u3081\u308b\uff09<\/li>\n\n\n\n<li>\u7761\u7720\u306e\u8cea\u5411\u4e0a\uff08\u795e\u7d4c\u5909\u6027\u75be\u60a3\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u306b\u3088\u308a\u3001\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u4eba\u3067\u3082\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u3092\u901a\u3058\u3066\u3001\u75c5\u6c17\u306e\u767a\u75c7\u3092\u9045\u3089\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>7. \u907a\u4f1d\u5b50\u7814\u7a76\u306e\u672a\u6765\uff1aAI\u3068\u500b\u5225\u5316\u533b\u7642<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7.1 AI\u306b\u3088\u308b\u907a\u4f1d\u5b50\u89e3\u6790\u306e\u9032\u5316<\/strong><\/h3>\n\n\n\n<p>AI\u3092\u6d3b\u7528\u3057\u305f\u30b2\u30ce\u30e0\u89e3\u6790\u306f\u3001\u75c5\u6c17\u306e\u30ea\u30b9\u30af\u4e88\u6e2c\u7cbe\u5ea6\u3092\u5411\u4e0a\u3055\u305b\u3066\u3044\u307e\u3059\u3002\u6a5f\u68b0\u5b66\u7fd2\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001<strong>\u6570\u767e\u4e07\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u540c\u6642\u306b\u89e3\u6790\u3057\u3001\u3088\u308a\u6b63\u78ba\u306a\u30ea\u30b9\u30af\u8a55\u4fa1\u304c\u53ef\u80fd<\/strong> \u3068\u306a\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2703-8\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7.2 CRISPR\u6280\u8853\u3068\u907a\u4f1d\u5b50\u6cbb\u7642<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\uff08CRISPR-Cas9\uff09\u3092\u6d3b\u7528\u3057\u3001\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u6301\u3064\u75be\u60a3\u306e\u6cbb\u7642\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001<strong>\u03b2\u30b5\u30e9\u30bb\u30df\u30a2<\/strong> \u3084 <strong>\u938c\u72b6\u8d64\u8840\u7403\u75c7<\/strong> \u306a\u3069\u306e\u907a\u4f1d\u6027\u75be\u60a3\u306f\u3001CRISPR\u306b\u3088\u3063\u3066\u6cbb\u7642\u53ef\u80fd\u306a\u6bb5\u968e\u306b\u5165\u308a\u3064\u3064\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/d41586-021-01462-0\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u89e3\u6790\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u75c5\u6c17\u30ea\u30b9\u30af\u306e\u4e88\u6e2c\u7cbe\u5ea6\u304c\u5411\u4e0a\u3057\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u5b9f\u73fe\u304c\u52a0\u901f\u3057\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u533b\u7642\u6226\u7565\u304c\u666e\u53ca\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u7cbe\u5bc6\u306a\u4e88\u9632\u533b\u5b66\u304c\u53ef\u80fd\u3068\u306a\u308a\u3001\u75c5\u6c17\u306e\u767a\u75c7\u3092\u672a\u7136\u306b\u9632\u3050\u65b0\u305f\u306a\u533b\u7642\u306e\u6642\u4ee3\u304c\u5230\u6765\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-e91b8edc-7fff-2de1-15b9-4c12a5bd3e7e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>8. \u907a\u4f1d\u5b50\u3068\u611f\u67d3\u75c7\u30ea\u30b9\u30af\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/31968313_m-1024x683.jpg\" alt=\"\u7814\u7a76\u6240\u3067\u5b9f\u9a13\u3092\u3059\u308b\u7814\u7a76\u8005\" class=\"wp-image-8153\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31968313_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31968313_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31968313_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31968313_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31968313_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8.1 \u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u3068\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h3>\n\n\n\n<p>\u611f\u67d3\u75c7\u306b\u5bfe\u3059\u308b\u62b5\u6297\u529b\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u7570\u306a\u308a\u307e\u3059\u3002\u514d\u75ab\u7cfb\u306e\u50cd\u304d\u3092\u5236\u5fa1\u3059\u308b\u907a\u4f1d\u5b50\u7fa4\u306b\u306f\u3001<strong>HLA\uff08\u30d2\u30c8\u767d\u8840\u7403\u6297\u539f\uff09\u907a\u4f1d\u5b50<\/strong> \u3084 <strong>TLR\uff08\u30c8\u30eb\u69d8\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50<\/strong> \u306a\u3069\u304c\u3042\u308a\u3001\u30a6\u30a4\u30eb\u30b9\u3084\u7d30\u83cc\u3078\u306e\u611f\u53d7\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2619-8\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u4ee3\u8868\u7684\u306a\u514d\u75ab\u95a2\u9023\u907a\u4f1d\u5b50\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>HLA\u907a\u4f1d\u5b50<\/strong>\uff1a\u6297\u539f\u63d0\u793a\u306e\u52b9\u7387\u3092\u6c7a\u5b9a\u3057\u3001\u30a6\u30a4\u30eb\u30b9\u3078\u306e\u514d\u75ab\u5fdc\u7b54\u3092\u5de6\u53f3\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>IFITM3\u907a\u4f1d\u5b50<\/strong>\uff1a\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u3084\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u3078\u306e\u611f\u53d7\u6027\u3092\u8abf\u7bc0\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>CCR5\u907a\u4f1d\u5b50<\/strong>\uff1aHIV\u611f\u67d3\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u5909\u7570\uff08CCR5-\u039432\u5909\u7570\uff09\u304c\u5b58\u5728\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>OAS1\u907a\u4f1d\u5b50<\/strong>\uff1a\u30a6\u30a4\u30eb\u30b9\u306e\u5897\u6b96\u3092\u9632\u3050\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u5fdc\u7b54\u306b\u95a2\u4e0e\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001<strong>HLA-B*57:01<\/strong> \u3092\u6301\u3064\u4eba\u306fHIV\u611f\u67d3\u5f8c\u306e\u9032\u884c\u304c\u9045\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u4e00\u65b9\u3067 <strong>HLA-B*15:01<\/strong> \u306f\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306e\u91cd\u75c7\u5316\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41591-020-1123-9\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8.2 \u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08COVID-19\uff09\u3068\u907a\u4f1d\u7684\u611f\u53d7\u6027<\/strong><\/h3>\n\n\n\n<p>COVID-19\u306e\u91cd\u75c7\u5316\u30ea\u30b9\u30af\u306b\u306f\u3001<strong>ACE2<\/strong> \u3084 <strong>TMPRSS2<\/strong> \u3068\u3044\u3063\u305f\u907a\u4f1d\u5b50\u304c\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002ACE2\u306f\u30a6\u30a4\u30eb\u30b9\u304c\u7d30\u80de\u306b\u4fb5\u5165\u3059\u308b\u969b\u306e\u53d7\u5bb9\u4f53\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3001\u305d\u306e\u767a\u73fe\u91cf\u304c\u9ad8\u3044\u3068\u611f\u67d3\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2285-5\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u907a\u4f1d\u5b50\u591a\u578b\u306b\u3088\u308a\u3001COVID-19\u611f\u67d3\u5f8c\u306e\u91cd\u75c7\u5316\u30ea\u30b9\u30af\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001<strong>OAS1\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8<\/strong> \u3092\u6301\u3064\u4eba\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u5f8c\u306e\u708e\u75c7\u5fdc\u7b54\u304c\u904e\u5270\u306b\u306a\u308a\u3084\u3059\u304f\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\uff08\u514d\u75ab\u904e\u5270\u53cd\u5fdc\uff09\u3092\u5f15\u304d\u8d77\u3053\u3059\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u611f\u67d3\u75c7\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3057\u3001\u500b\u5225\u306e\u6cbb\u7642\u3084\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u6226\u7565\u3092\u6700\u9069\u5316\u3059\u308b\u3053\u3068\u304c\u3001\u4eca\u5f8c\u306e\u516c\u8846\u885b\u751f\u6226\u7565\u306e\u9375\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>9. \u907a\u4f1d\u5b50\u3068\u7cbe\u795e\u75be\u60a3\u306e\u30ea\u30b9\u30af\u4e88\u6e2c<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9.1 \u907a\u4f1d\u7684\u8981\u56e0\u3068\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9<\/strong><\/h3>\n\n\n\n<p>\u7cbe\u795e\u75be\u60a3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306f\u3001\u907a\u4f1d\u3068\u74b0\u5883\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u6c7a\u307e\u308a\u307e\u3059\u3002\u3046\u3064\u75c5\u3001\u7d71\u5408\u5931\u8abf\u75c7\u3001\u53cc\u6975\u6027\u969c\u5bb3\u306a\u3069\u306f\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41398-020-01053-7\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u4ee3\u8868\u7684\u306a\u7cbe\u795e\u75be\u60a3\u95a2\u9023\u907a\u4f1d\u5b50\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>5-HTTLPR\uff08\u30bb\u30ed\u30c8\u30cb\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u907a\u4f1d\u5b50\uff09<\/strong>\uff1a\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u518d\u53d6\u308a\u8fbc\u307f\u3092\u8abf\u7bc0\u3057\u3001\u3046\u3064\u75c5\u306e\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3002<\/li>\n\n\n\n<li><strong>COMT\uff08\u30ab\u30c6\u30b3\u30fc\u30eb-O-\u30e1\u30c1\u30eb\u8ee2\u79fb\u9175\u7d20\u907a\u4f1d\u5b50\uff09<\/strong>\uff1a\u30c9\u30fc\u30d1\u30df\u30f3\u306e\u4ee3\u8b1d\u3092\u5236\u5fa1\u3057\u3001\u7d71\u5408\u5931\u8abf\u75c7\u306e\u30ea\u30b9\u30af\u306b\u95a2\u4e0e\u3002<\/li>\n\n\n\n<li><strong>BDNF\uff08\u8133\u7531\u6765\u795e\u7d4c\u6804\u990a\u56e0\u5b50\u907a\u4f1d\u5b50\uff09<\/strong>\uff1a\u795e\u7d4c\u53ef\u5851\u6027\u3092\u8abf\u6574\u3057\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3084\u8a8d\u77e5\u6a5f\u80fd\u306b\u5f71\u97ff\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u7279\u306b <strong>5-HTTLPR\u306e\u77ed\u3044\u30d0\u30ea\u30a2\u30f3\u30c8\uff08S\u578b\uff09<\/strong> \u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u3046\u3064\u75c5\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001<strong>BDNF Val66Met\u5909\u7570<\/strong> \u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u304f\u3001\u4e0d\u5b89\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41398-019-0386-9\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9.2 \u7cbe\u795e\u75be\u60a3\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u3068\u500b\u5225\u5316\u6cbb\u7642<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/29757183_m-1024x683.jpg\" alt=\"\u30a6\u30a3\u30eb\u30b9\u3092\u78ba\u8a8d\u3059\u308b\u4eba\u306e\u624b\u5143\" class=\"wp-image-9144\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29757183_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29757183_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29757183_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29757183_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29757183_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u7cbe\u795e\u75be\u60a3\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u4eba\u306b\u5bfe\u3057\u3066\u3001\u65e9\u671f\u4ecb\u5165\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001<strong>SSRI\uff08\u9078\u629e\u7684\u30bb\u30ed\u30c8\u30cb\u30f3\u518d\u53d6\u308a\u8fbc\u307f\u963b\u5bb3\u85ac\uff09\u306e\u52b9\u679c\u304c\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u7570\u306a\u308b<\/strong> \u3053\u3068\u304c\u5224\u660e\u3057\u3066\u304a\u308a\u3001CYP2C19\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u6700\u9069\u306a\u85ac\u5264\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41591-019-0654-x\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>DHA\uff08\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff09\u3084\u30d3\u30bf\u30df\u30f3D\u306e\u6442\u53d6<\/strong> \u304c\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306b\u304a\u3044\u3066\u6c17\u5206\u5b89\u5b9a\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u3082\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u500b\u5225\u5316\u533b\u7642\u304c\u9032\u3080\u3053\u3068\u3067\u3001\u7cbe\u795e\u75be\u60a3\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u3082\u3088\u308a\u7cbe\u5bc6\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-e91b8edc-7fff-2de1-15b9-4c12a5bd3e7e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>10. \u907a\u4f1d\u5b50\u3068\u9577\u5bff\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10.1 \u907a\u4f1d\u5b50\u304c\u5bff\u547d\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<p>\u4eba\u306e\u5bff\u547d\u306f\u3001\u74b0\u5883\u8981\u56e0\u3060\u3051\u3067\u306a\u304f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3082\u5de6\u53f3\u3055\u308c\u307e\u3059\u3002\u9577\u5bff\u306e\u5bb6\u7cfb\u3067\u306f\u3001<strong>FOXO3<\/strong> \u3084 <strong>SIRT1<\/strong> \u306a\u3069\u306e\u907a\u4f1d\u5b50\u304c\u9577\u5bff\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41586-019-1423-7\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u4ee3\u8868\u7684\u306a\u9577\u5bff\u95a2\u9023\u907a\u4f1d\u5b50\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FOXO3\u907a\u4f1d\u5b50<\/strong>\uff1a\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3092\u5411\u4e0a\u3057\u3001\u7d30\u80de\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u3002<\/li>\n\n\n\n<li><strong>SIRT1\u907a\u4f1d\u5b50<\/strong>\uff1aDNA\u4fee\u5fa9\u3092\u4fc3\u9032\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u3092\u7dad\u6301\u3002<\/li>\n\n\n\n<li><strong>APOE \u03b52\u907a\u4f1d\u5b50<\/strong>\uff1a\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3057\u3001\u9577\u5bff\u306b\u5bc4\u4e0e\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10.2 \u907a\u4f1d\u5b50\u306b\u57fa\u3065\u3044\u305f\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u6226\u7565<\/strong><\/h3>\n\n\n\n<p>\u9577\u5bff\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u3092\u6d3b\u6027\u5316\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u751f\u6d3b\u7fd2\u6163\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u306e\u6442\u53d6\uff08\u8d64\u30ef\u30a4\u30f3\u3001\u30d6\u30c9\u30a6\uff09<\/strong>\uff1aSIRT1\u3092\u6d3b\u6027\u5316\u3057\u3001\u7d30\u80de\u306e\u8001\u5316\u3092\u9632\u3050\u3002<\/li>\n\n\n\n<li><strong>\u9069\u5ea6\u306a\u30ab\u30ed\u30ea\u30fc\u5236\u9650\uff08\u30a4\u30f3\u30bf\u30fc\u30df\u30c3\u30c6\u30f3\u30c8\u30d5\u30a1\u30b9\u30c6\u30a3\u30f3\u30b0\uff09<\/strong>\uff1aFOXO3\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u3001\u5065\u5eb7\u5bff\u547d\u3092\u5ef6\u3070\u3059\u3002<\/li>\n\n\n\n<li><strong>\u904b\u52d5\uff08\u7279\u306b\u6709\u9178\u7d20\u904b\u52d5\uff09<\/strong>\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u3092\u6700\u9069\u5316\u3057\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u4f4e\u6e1b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u3001\u907a\u4f1d\u7684\u306b\u9577\u5bff\u30ea\u30b9\u30af\u304c\u4f4e\u3044\u4eba\u3067\u3082\u5065\u5eb7\u5bff\u547d\u3092\u5ef6\u3070\u3059\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u3068\u75c5\u6c17\u30ea\u30b9\u30af\u306e\u4e88\u6e2c\u306f\u3001\u611f\u67d3\u75c7\u3001\u7cbe\u795e\u75be\u60a3\u3001\u8001\u5316\u306a\u3069\u5e45\u5e83\u3044\u5206\u91ce\u306b\u5fdc\u7528\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u6280\u8853\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u3088\u308a\u7cbe\u5bc6\u306a\u500b\u5225\u5316\u533b\u7642\u304c\u5b9f\u73fe\u3057\u3001\u4e88\u9632\u533b\u5b66\u306e\u65b0\u305f\u306a\u6642\u4ee3\u304c\u5230\u6765\u3057\u3088\u3046\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-e91b8edc-7fff-2de1-15b9-4c12a5bd3e7e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>11. \u907a\u4f1d\u5b50\u3068\u4ee3\u8b1d\u7570\u5e38\uff1a\u7cd6\u5c3f\u75c5\u30fb\u80a5\u6e80\u30ea\u30b9\u30af\u306e\u4e88\u6e2c<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/25114368_m-1024x683.jpg\" alt=\"\u4f53\u91cd\u8a08\u306b\u4e57\u3063\u305f\u8db3\u5143\u3000\u30c0\u30a4\u30a8\u30c3\u30c8\u30a4\u30e1\u30fc\u30b8\" class=\"wp-image-7720\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/25114368_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/25114368_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/25114368_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/25114368_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/25114368_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>11.1 \u907a\u4f1d\u7684\u8981\u56e0\u3068\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af<\/strong><\/h3>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u751f\u6d3b\u7fd2\u6163\u304c\u8907\u96d1\u306b\u95a2\u4e0e\u3059\u308b\u75be\u60a3\u306e\u4e00\u3064\u3067\u3059\u3002\u7279\u306b <strong>2\u578b\u7cd6\u5c3f\u75c5<\/strong> \u3067\u306f\u3001\u8907\u6570\u306e\u907a\u4f1d\u5b50\u304c\u767a\u75c7\u30ea\u30b9\u30af\u3092\u6c7a\u5b9a\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/nature18642\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u4ee3\u8868\u7684\u306a\u7cd6\u5c3f\u75c5\u95a2\u9023\u907a\u4f1d\u5b50\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>TCF7L2\u907a\u4f1d\u5b50<\/strong>\uff1a\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u8abf\u6574\u3057\u3001\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u3002<\/li>\n\n\n\n<li><strong>SLC30A8\u907a\u4f1d\u5b50<\/strong>\uff1a\u81b5\u81d3\u03b2\u7d30\u80de\u306e\u6a5f\u80fd\u306b\u95a2\u4e0e\u3057\u3001\u8840\u7cd6\u5024\u306e\u5236\u5fa1\u306b\u5f71\u97ff\u3002<\/li>\n\n\n\n<li><strong>PPARG\u907a\u4f1d\u5b50<\/strong>\uff1a\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u6c7a\u5b9a\u3057\u3001\u7cd6\u306e\u4ee3\u8b1d\u3092\u8abf\u6574\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>TCF7L2\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba<\/strong> \u306f\u3001\u901a\u5e38\u306e3\u500d\u4ee5\u4e0a\u306e\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u6301\u3064\u3068\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u65e9\u671f\u306e\u8840\u7cd6\u7ba1\u7406\u304c\u5fc5\u8981\u3068\u306a\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3346827\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>11.2 \u7cd6\u5c3f\u75c5\u4e88\u9632\u306e\u305f\u3081\u306e\u907a\u4f1d\u5b50\u30d9\u30fc\u30b9\u306e\u4ecb\u5165<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u4eba\u306b\u9069\u3057\u305f\u98df\u4e8b\u3084\u904b\u52d5\u30d7\u30e9\u30f3\u3092\u7b56\u5b9a\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4f4e\u70ad\u6c34\u5316\u7269\u30fb\u9ad8\u30bf\u30f3\u30d1\u30af\u8cea\u98df<\/strong>\uff08TCF7L2\u5909\u7570\u3092\u6301\u3064\u4eba\u306b\u63a8\u5968\uff09<\/li>\n\n\n\n<li><strong>\u6709\u9178\u7d20\u904b\u52d5\uff0b\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u904b\u52d5<\/strong>\uff08SLC30A8\u5909\u7570\u306b\u3088\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u4f4e\u4e0b\u3092\u88dc\u3046\uff09<\/li>\n\n\n\n<li><strong>\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u306e\u6442\u53d6<\/strong>\uff08PPARG\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306b\u52b9\u679c\u7684\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u7279\u306b\u3001\u65e9\u671f\u306e\u98df\u4e8b\u4ecb\u5165\u304c\u7cd6\u5c3f\u75c5\u767a\u75c7\u3092\u9632\u3050\u9375\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-e91b8edc-7fff-2de1-15b9-4c12a5bd3e7e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>11.3 \u907a\u4f1d\u5b50\u3068\u80a5\u6e80\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u80a5\u6e80\u306f <strong>FTO\u907a\u4f1d\u5b50<\/strong> \u3084 <strong>MC4R\u907a\u4f1d\u5b50<\/strong> \u306a\u3069\u306e\u591a\u304f\u306e\u907a\u4f1d\u5b50\u3068\u95a2\u9023\u304c\u3042\u308a\u3001\u500b\u3005\u306e\u907a\u4f1d\u7684\u80cc\u666f\u306b\u3088\u308a\u3001\u8102\u80aa\u306e\u84c4\u7a4d\u30d1\u30bf\u30fc\u30f3\u304c\u7570\u306a\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/ng.408\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u4ee3\u8868\u7684\u306a\u80a5\u6e80\u95a2\u9023\u907a\u4f1d\u5b50\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FTO\u907a\u4f1d\u5b50<\/strong>\uff1a\u98df\u6b32\u3084\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u3092\u8abf\u6574\u3057\u3001\u80a5\u6e80\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3002<\/li>\n\n\n\n<li><strong>MC4R\u907a\u4f1d\u5b50<\/strong>\uff1a\u8133\u306e\u98df\u6b32\u6291\u5236\u6a5f\u80fd\u306b\u95a2\u4e0e\u3057\u3001\u904e\u98df\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u3002<\/li>\n\n\n\n<li><strong>LEPR\u907a\u4f1d\u5b50<\/strong>\uff1a\u30ec\u30d7\u30c1\u30f3\uff08\u98df\u6b32\u6291\u5236\u30db\u30eb\u30e2\u30f3\uff09\u306e\u53d7\u5bb9\u4f53\u6a5f\u80fd\u3092\u5236\u5fa1\u3002<\/li>\n<\/ul>\n\n\n\n<p>FTO\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u901a\u5e38\u306e\u4eba\u3088\u308a\u3082\u30ab\u30ed\u30ea\u30fc\u6d88\u8cbb\u304c\u4f4e\u304f\u3001\u98df\u4e8b\u5236\u9650\u3060\u3051\u3067\u306f\u52b9\u679c\u304c\u51fa\u306b\u304f\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41591-019-0508-7\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>11.4 \u80a5\u6e80\u4e88\u9632\u3068\u907a\u4f1d\u5b50\u306e\u6d3b\u7528<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u3082\u3068\u306b\u3001\u80a5\u6e80\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u305f\u3081\u306e\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u5909\u66f4\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4f4e\u8102\u80aa\u30fb\u9ad8\u30bf\u30f3\u30d1\u30af\u8cea\u98df<\/strong>\uff08FTO\u30ea\u30b9\u30af\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306b\u6709\u52b9\uff09<\/li>\n\n\n\n<li><strong>\u30a4\u30f3\u30bf\u30fc\u30df\u30c3\u30c6\u30f3\u30c8\u30d5\u30a1\u30b9\u30c6\u30a3\u30f3\u30b0<\/strong>\uff08LEPR\u5909\u7570\u306b\u3088\u308b\u30ec\u30d7\u30c1\u30f3\u62b5\u6297\u6027\u3092\u6539\u5584\uff09<\/li>\n\n\n\n<li><strong>\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\uff08MC4R\u5909\u7570\u3092\u6301\u3064\u4eba\u306e\u57fa\u790e\u4ee3\u8b1d\u3092\u5411\u4e0a\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u4ecb\u5165\u306b\u3088\u308a\u3001\u907a\u4f1d\u7684\u306b\u80a5\u6e80\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba\u3067\u3082\u5065\u5eb7\u306a\u4f53\u91cd\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>12. \u907a\u4f1d\u5b50\u3068\u9aa8\u5bc6\u5ea6\uff1a\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u30ea\u30b9\u30af\u306e\u4e88\u6e2c<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/30532404_m-1024x683.jpg\" alt=\"\n\u30ec\u30f3\u30c8\u30b2\u30f3\u5199\u771f\u3092\u30ec\u30f3\u30c8\u30b2\u30f3\u5199\u771f\u3092\u898b\u305b\u308b\u5973\u6027\" class=\"wp-image-9777\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30532404_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30532404_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30532404_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30532404_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30532404_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12.1 \u9aa8\u5bc6\u5ea6\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u9aa8\u306e\u5f37\u5ea6\u306f\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u5f71\u97ff\u3055\u308c\u3001\u7279\u306b <strong>VDR\uff08\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50<\/strong> \u3084 <strong>COL1A1\uff08\u30b3\u30e9\u30fc\u30b2\u30f3\u907a\u4f1d\u5b50\uff09<\/strong> \u304c\u9aa8\u5bc6\u5ea6\u306e\u6c7a\u5b9a\u306b\u95a2\u4e0e\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/ng.283\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u4ee3\u8868\u7684\u306a\u9aa8\u5bc6\u5ea6\u95a2\u9023\u907a\u4f1d\u5b50\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>VDR\u907a\u4f1d\u5b50<\/strong>\uff1a\u30d3\u30bf\u30df\u30f3D\u306e\u5438\u53ce\u52b9\u7387\u3092\u6c7a\u5b9a\u3057\u3001\u9aa8\u5bc6\u5ea6\u306b\u5f71\u97ff\u3002<\/li>\n\n\n\n<li><strong>COL1A1\u907a\u4f1d\u5b50<\/strong>\uff1a\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u5f62\u6210\u3092\u8abf\u6574\u3057\u3001\u9aa8\u306e\u5f37\u5ea6\u3092\u6c7a\u5b9a\u3002<\/li>\n\n\n\n<li><strong>LRP5\u907a\u4f1d\u5b50<\/strong>\uff1a\u9aa8\u5f62\u6210\u306b\u95a2\u4e0e\u3057\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u30ea\u30b9\u30af\u3092\u5de6\u53f3\u3002<\/li>\n<\/ul>\n\n\n\n<p>VDR\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u5438\u53ce\u304c\u4f4e\u4e0b\u3057\u3001\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u304f\u306a\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3898922\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12.2 \u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u4e88\u9632<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d3\u30bf\u30df\u30f3D\u5f37\u5316\u98df\u54c1\u3092\u6442\u53d6<\/strong>\uff08VDR\u5909\u7570\u3092\u6301\u3064\u4eba\u5411\u3051\uff09<\/li>\n\n\n\n<li><strong>\u30ab\u30eb\u30b7\u30a6\u30e0\u6442\u53d6\u91cf\u3092\u5897\u52a0<\/strong>\uff08COL1A1\u5909\u7570\u306b\u3088\u308b\u9aa8\u5bc6\u5ea6\u4f4e\u4e0b\u3092\u9632\u3050\uff09<\/li>\n\n\n\n<li><strong>\u8ca0\u8377\u306e\u304b\u304b\u308b\u904b\u52d5\uff08\u30b8\u30e3\u30f3\u30d7\u904b\u52d5\uff09<\/strong>\uff08LRP5\u5909\u7570\u3092\u6301\u3064\u4eba\u306e\u9aa8\u5f62\u6210\u3092\u4fc3\u9032\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u3063\u3066\u3001\u9aa8\u306e\u5065\u5eb7\u3092\u4fdd\u3064\u305f\u3081\u306e\u500b\u5225\u5316\u6226\u7565\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-e91b8edc-7fff-2de1-15b9-4c12a5bd3e7e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>13. \u907a\u4f1d\u5b50\u3068\u85ac\u306e\u4ee3\u8b1d\uff1a\u500b\u5225\u5316\u85ac\u7269\u7642\u6cd5<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>13.1 \u907a\u4f1d\u5b50\u3068\u85ac\u5264\u5fdc\u7b54<\/strong><\/h3>\n\n\n\n<p>\u85ac\u306e\u52b9\u679c\u3084\u526f\u4f5c\u7528\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u7570\u306a\u308a\u307e\u3059\u3002<strong>CYP450\u907a\u4f1d\u5b50\u7fa4<\/strong> \u306f\u85ac\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3057\u3001\u500b\u4eba\u306e\u85ac\u7269\u5fdc\u7b54\u3092\u6c7a\u5b9a\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41576-019-0101-3\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u4ee3\u8868\u7684\u306a\u85ac\u7269\u4ee3\u8b1d\u95a2\u9023\u907a\u4f1d\u5b50\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CYP2D6<\/strong>\uff1a\u6297\u3046\u3064\u85ac\u3084\u93ae\u75db\u5264\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3002<\/li>\n\n\n\n<li><strong>CYP2C19<\/strong>\uff1a\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff08PPI\uff09\u3084\u6297\u8840\u5c0f\u677f\u85ac\uff08\u30af\u30ed\u30d4\u30c9\u30b0\u30ec\u30eb\uff09\u306e\u4ee3\u8b1d\u306b\u5f71\u97ff\u3002<\/li>\n\n\n\n<li><strong>CYP3A4<\/strong>\uff1a\u30b9\u30bf\u30c1\u30f3\uff08\u8102\u8cea\u7570\u5e38\u75c7\u6cbb\u7642\u85ac\uff09\u3084\u514d\u75ab\u6291\u5236\u5264\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001CYP2C19\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u30af\u30ed\u30d4\u30c9\u30b0\u30ec\u30eb\uff08\u8840\u6db2\u3092\u30b5\u30e9\u30b5\u30e9\u306b\u3059\u308b\u85ac\uff09\u306e\u52b9\u679c\u304c\u4f4e\u4e0b\u3059\u308b\u305f\u3081\u3001\u7570\u306a\u308b\u6297\u8840\u5c0f\u677f\u85ac\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\uff08<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa0808210\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>13.2 \u907a\u4f1d\u5b50\u306b\u57fa\u3065\u3044\u305f\u85ac\u306e\u500b\u5225\u5316<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6297\u3046\u3064\u85ac\u306e\u6295\u4e0e\u91cf\u3092\u8abf\u6574<\/strong>\uff08CYP2D6\u306e\u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u3066\u5909\u66f4\uff09<\/li>\n\n\n\n<li><strong>PPI\uff08\u80c3\u85ac\uff09\u306e\u9078\u629e\u3092\u6700\u9069\u5316<\/strong>\uff08CYP2C19\u5909\u7570\u306b\u3088\u308a\u52b9\u679c\u304c\u7570\u306a\u308b\uff09<\/li>\n\n\n\n<li><strong>\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u306e\u30ea\u30b9\u30af\u7ba1\u7406<\/strong>\uff08CYP3A4\u306e\u4ee3\u8b1d\u80fd\u529b\u306b\u5fdc\u3058\u3066\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\uff09<\/li>\n<\/ul>\n\n\n\n<p><strong>\u6297\u304c\u3093\u5264\u306e\u52b9\u679c\u4e88\u6e2c<\/strong>\uff08TPMT\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u308a\u9069\u5207\u306a\u85ac\u5264\u9078\u629e\uff09<\/p>\n\n\n\n<p>&nbsp;<strong>\u8840\u5727\u964d\u4e0b\u85ac\u306e\u8abf\u6574<\/strong>\uff08ACE\u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u3066\u6700\u9069\u306a\u6cbb\u7642\u8a08\u753b\u3092\u7b56\u5b9a\uff09<\/p>\n\n\n\n<p><strong>\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u306e\u9078\u629e<\/strong>\uff08KCNJ11\u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u3066\u85ac\u52b9\u3092\u6700\u9069\u5316\uff09<\/p>\n\n\n\n<p>\u3053\u308c\u306b\u3088\u308a\u3001\u500b\u3005\u306e\u60a3\u8005\u306b\u6700\u9069\u306a\u85ac\u5264\u9078\u629e\u304c\u53ef\u80fd\u3068\u306a\u308a\u3001\u52b9\u679c\u7684\u306a\u6cbb\u7642\u3092\u5b9f\u73fe\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u7cd6\u5c3f\u75c5\u3001\u80a5\u6e80\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u3001\u85ac\u7269\u7642\u6cd5\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u75be\u60a3\u306e\u30ea\u30b9\u30af\u4e88\u6e2c\u3068\u500b\u5225\u5316\u533b\u7642\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u3088\u308a\u7cbe\u5bc6\u306a\u533b\u7642\u6226\u7565\u306e\u5b9f\u73fe\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-e91b8edc-7fff-2de1-15b9-4c12a5bd3e7e\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<p><strong>\u307e\u3068\u3081<\/strong><\/p>\n\n\n\n<p>\u907a\u4f1d\u5b50\u89e3\u6790\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u75c5\u6c17\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3057\u3001\u500b\u5225\u5316\u533b\u7642\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<strong>BRCA1\/BRCA2<\/strong> \u306f\u4e73\u304c\u3093\u30ea\u30b9\u30af\u3001<strong>APOE \u03b54<\/strong> \u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u30ea\u30b9\u30af\u3001<strong>TCF7L2<\/strong> \u306f\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u5de6\u53f3\u3057\u3001<strong>FTO<\/strong> \u306f\u80a5\u6e80\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u4f53\u8cea\u3092\u6c7a\u5b9a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>HLA\u907a\u4f1d\u5b50<\/strong> \u306f\u611f\u67d3\u75c7\u306e\u611f\u53d7\u6027\u3092\u3001<strong>CYP450<\/strong> \u306f\u85ac\u7269\u306e\u4ee3\u8b1d\u80fd\u529b\u3092\u8abf\u7bc0\u3057\u307e\u3059\u3002\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u9069\u5207\u306a\u4e88\u9632\u7b56\u3001\u98df\u4e8b\u3001\u904b\u52d5\u3001\u85ac\u7269\u7642\u6cd5<\/strong> \u3092\u500b\u3005\u306b\u6700\u9069\u5316\u3067\u304d\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u5065\u5eb7\u7ba1\u7406\u3068\u75c5\u6c17\u4e88\u9632\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u75c5\u6c17\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4e8b\u524d\u306b\u4e88\u6e2c\u3057\u3001\u500b\u5225\u5316\u533b\u7642\u3092\u5b9f\u73fe\u3059\u308b\u53d6\u308a\u7d44\u307f\u304c\u52a0\u901f\u3057\u3066\u3044\u307e\u3059\u3002\u30b2\u30ce\u30e0\u89e3\u6790 \u3084 \u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30b9\u30b3\u30a2\uff08Polygenic Risk Score\uff1aPRS\uff09 \u3092\u6d3b\u7528\u3057\u305f\u4e88\u6e2c\u6280\u8853\u306f\u3001\u5fc3\u8840\u7ba1 [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":9763,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9762","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/9762","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=9762"}],"version-history":[{"count":1,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/9762\/revisions"}],"predecessor-version":[{"id":9784,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/9762\/revisions\/9784"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/9763"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=9762"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=9762"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=9762"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}