{"id":9931,"date":"2025-03-12T07:59:22","date_gmt":"2025-03-12T07:59:22","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=9931"},"modified":"2025-03-12T07:59:24","modified_gmt":"2025-03-12T07:59:24","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e9%aa%a8%e7%b2%97%e3%81%97%e3%82%87%e3%81%86%e7%97%87%e3%81%ae%e4%ba%88%e9%98%b2%ef%bc%9a%e9%81%ba%e4%bc%9d%e7%9a%84%e8%a6%81%e7%b4%a0%e3%81%ab%e5%9f%ba%e3%81%a5","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e9%aa%a8%e7%b2%97%e3%81%97%e3%82%87%e3%81%86%e7%97%87%e3%81%ae%e4%ba%88%e9%98%b2%ef%bc%9a%e9%81%ba%e4%bc%9d%e7%9a%84%e8%a6%81%e7%b4%a0%e3%81%ab%e5%9f%ba%e3%81%a5\/","title":{"rendered":"\u907a\u4f1d\u5b50\u3068\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u4e88\u9632\uff1a\u907a\u4f1d\u7684\u8981\u7d20\u306b\u57fa\u3065\u304f\u5bfe\u7b56"},"content":{"rendered":"\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u306f\u3058\u3081\u306b<\/strong><\/h2>\n\n\n\n<p>\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306f\u3001\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u4e0b\u3057\u3001\u9aa8\u6298\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u75be\u60a3\u3067\u3059\u3002\u52a0\u9f62\u3084\u751f\u6d3b\u7fd2\u6163\u3001\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306e\u5909\u5316\u304c\u4e3b\u306a\u8981\u56e0\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u907a\u4f1d\u7684\u306a\u8981\u7d20\u3082\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u591a\u578b\u304c\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3084\u9aa8\u6298\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u672c\u8a18\u4e8b\u3067\u306f\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u3084\u3001\u907a\u4f1d\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u4e88\u9632\u7b56\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>1. \u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h2>\n\n\n\n<p>\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306b\u306f\u3001\u8907\u6570\u306e\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u9aa8\u306e\u5f62\u6210\u3084\u5438\u53ce\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1-1. VDR\u907a\u4f1d\u5b50\u3068\u30d3\u30bf\u30df\u30f3D\u4ee3\u8b1d<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>VDR\uff08\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong> VDR\u907a\u4f1d\u5b50\u306f\u3001\u4f53\u5185\u306e\u30d3\u30bf\u30df\u30f3D\u306e\u50cd\u304d\u3092\u8abf\u7bc0\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u30d3\u30bf\u30df\u30f3D\u306f\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u5438\u53ce\u3092\u52a9\u3051\u308b\u305f\u3081\u3001VDR\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\n<ul class=\"wp-block-list\">\n<li><strong>\u7279\u5b9a\u306eVDR\u907a\u4f1d\u5b50\u591a\u578b\uff08BsmI, ApaI, TaqI\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u3044\u50be\u5411\u304c\u3042\u308b\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u30d3\u30bf\u30df\u30f3D\u306e\u88dc\u7d66\u304c\u7279\u306b\u91cd\u8981\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/onlinelibrary.wiley.com\/journal\/15234681\">VDR\u907a\u4f1d\u5b50\u3068\u9aa8\u5bc6\u5ea6\uff08Journal of Bone and Mineral Research\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1-2. COL1A1\u907a\u4f1d\u5b50\u3068\u9aa8\u306e\u5f37\u5ea6<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>COL1A1\uff08\u30b3\u30e9\u30fc\u30b2\u30f3I\u578b\u03b11\u9396\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong> \u30b3\u30e9\u30fc\u30b2\u30f3\u306f\u9aa8\u306e\u4e3b\u8981\u69cb\u6210\u6210\u5206\u3067\u3042\u308a\u3001COL1A1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u9aa8\u306e\u5f37\u5ea6\u304c\u4f4e\u4e0b\u3057\u3001\u9aa8\u6298\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3002\n<ul class=\"wp-block-list\">\n<li><strong>\u300cTT\u578b\u300d\u3092\u6301\u3064\u4eba\u306f\u3001\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u304f\u9aa8\u6298\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u30d3\u30bf\u30df\u30f3C\u306e\u6442\u53d6\u304c\u91cd\u8981\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.springer.com\/journal\/198\">COL1A1\u3068\u9aa8\u6298\u30ea\u30b9\u30af\uff08Osteoporosis International\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1-3. LRP5\u907a\u4f1d\u5b50\u3068\u9aa8\u5f62\u6210<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>LRP5\uff08\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u53d7\u5bb9\u4f53\u95a2\u9023\u30bf\u30f3\u30d1\u30af5\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong> LRP5\u306f\u9aa8\u306e\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\u5f79\u5272\u3092\u6301\u3064\u3002\u7279\u5b9a\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u9aa8\u5f62\u6210\u304c\u4f4e\u4e0b\u3057\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3002\n<ul class=\"wp-block-list\">\n<li><strong>\u300cG171V\u5909\u7570\u300d\u3092\u6301\u3064\u4eba\u306f\u3001\u9aa8\u91cf\u304c\u4f4e\u304f\u3001\u9aa8\u6298\u3057\u3084\u3059\u3044\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u904b\u52d5\u3068\u30ab\u30eb\u30b7\u30a6\u30e0\u6442\u53d6\u3092\u610f\u8b58\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/articles\/ng\">LRP5\u3068\u9aa8\u7c97\u3057\u3087\u3046\u75c7\uff08Nature Genetics\uff09<\/a><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. \u907a\u4f1d\u5b50\u306b\u57fa\u3065\u304f\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u4e88\u9632\u7b56<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/30960299_m-1024x683.jpg\" alt=\"\" class=\"wp-image-9939\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30960299_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30960299_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30960299_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30960299_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30960299_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u4e88\u9632\u7b56\u3092\u7acb\u3066\u308b\u3053\u3068\u3067\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3092\u6291\u3048\u3001\u9aa8\u6298\u30ea\u30b9\u30af\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2-1. \u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u6804\u990a\u6226\u7565<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>VDR\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306e\u5bfe\u7b56<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30d3\u30bf\u30df\u30f3D\u3092\u591a\u304f\u542b\u3080\u98df\u54c1\uff08\u9b5a\u3001\u5375\u3001\u304d\u306e\u3053\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3002<\/li>\n\n\n\n<li>\u65e5\u5149\u6d74\u3092\u7fd2\u6163\u5316\u3057\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u751f\u6210\u3092\u4fc3\u9032\u3002<\/li>\n\n\n\n<li>\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u5229\u7528\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>COL1A1\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306e\u5bfe\u7b56<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u5408\u6210\u3092\u52a9\u3051\u308b\u30d3\u30bf\u30df\u30f3C\uff08\u67d1\u6a58\u985e\u3001\u30d4\u30fc\u30de\u30f3\uff09\u3092\u6442\u53d6\u3002<\/li>\n\n\n\n<li>\u9ad8\u54c1\u8cea\u306a\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u5927\u8c46\u3001\u9b5a\u3001\u9d8f\u8089\uff09\u3092\u610f\u8b58\u7684\u306b\u6442\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>LRP5\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306e\u5bfe\u7b56<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30ab\u30eb\u30b7\u30a6\u30e0\u3092\u591a\u304f\u542b\u3080\u98df\u54c1\uff08\u4e73\u88fd\u54c1\u3001\u5c0f\u9b5a\u3001\u8449\u7269\u91ce\u83dc\uff09\u3092\u6442\u53d6\u3002<\/li>\n\n\n\n<li>\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u3068\u4e9c\u925b\u3092\u542b\u3080\u98df\u54c1\uff08\u30ca\u30c3\u30c4\u3001\u8c46\u985e\uff09\u3092\u53d6\u308a\u5165\u308c\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a\u6804\u990a\u3068\u9aa8\u5bc6\u5ea6\uff08The American Journal of Clinical Nutrition\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2-2. \u9aa8\u5bc6\u5ea6\u3092\u9ad8\u3081\u308b\u305f\u3081\u306e\u904b\u52d5\u30d7\u30ed\u30b0\u30e9\u30e0<\/strong><\/h3>\n\n\n\n<p>\u9aa8\u306f\u8ca0\u8377\u3092\u53d7\u3051\u308b\u3053\u3068\u3067\u5f37\u304f\u306a\u308b\u305f\u3081\u3001\u9069\u5207\u306a\u904b\u52d5\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u578b\u306b\u57fa\u3065\u3044\u305f\u904b\u52d5\u30d7\u30ed\u30b0\u30e9\u30e0<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u3044\u907a\u4f1d\u578b\u306e\u4eba\uff08VDR, LRP5\u5909\u7570\uff09<\/strong> \u2192 <strong>\u30a6\u30a7\u30a4\u30c8\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3084\u30b8\u30e3\u30f3\u30d7\u904b\u52d5\u3092\u63a8\u5968\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u95a2\u7bc0\u306e\u67d4\u8edf\u6027\u304c\u4f4e\u3044\u907a\u4f1d\u578b\u306e\u4eba\uff08COL1A1\u5909\u7570\uff09<\/strong> \u2192 <strong>\u30e8\u30ac\u3084\u30d4\u30e9\u30c6\u30a3\u30b9\u3067\u9aa8\u3068\u95a2\u7bc0\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u6574\u3048\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.springer.com\/journal\/40279\">\u904b\u52d5\u3068\u9aa8\u5bc6\u5ea6\uff08Sports Medicine Journal\uff09<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5bfe\u5fdc\u30d7\u30e9\u30f3<\/strong><\/h2>\n\n\n\n<p>\u8fd1\u5e74\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u533b\u7642\u304c\u9032\u3093\u3067\u304a\u308a\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u4e88\u9632\u306b\u3082\u5fdc\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3-1. \u907a\u4f1d\u5b50\u691c\u67fb\u3067\u9aa8\u5bc6\u5ea6\u30ea\u30b9\u30af\u3092\u8a55\u4fa1<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>HLA\u907a\u4f1d\u5b50\u3068\u81ea\u5df1\u514d\u75ab\u6027\u9aa8\u75be\u60a3\u306e\u95a2\u4fc2<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>HLA-B27\u3092\u6301\u3064\u4eba\u306f\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3084\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li>\u708e\u75c7\u3092\u6291\u3048\u308b\u98df\u4e8b\uff08\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3001\u6297\u9178\u5316\u98df\u54c1\uff09\u3092\u610f\u8b58\u3059\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\u907a\u4f1d\u5b50\uff08ESR1\uff09\u3068\u5973\u6027\u306e\u9aa8\u5bc6\u5ea6<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>ESR1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u9589\u7d4c\u5f8c\u306e\u9aa8\u5bc6\u5ea6\u4f4e\u4e0b\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u305f\u3081\u3001\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u3092\u8003\u616e\u3057\u305f\u5bfe\u7b56\u304c\u5fc5\u8981\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u3068\u907a\u4f1d\u5b50\u691c\u67fb\uff08Journal of Clinical Endocrinology &amp; Metabolism\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3-2. \u907a\u4f1d\u5b50\u306b\u57fa\u3065\u3044\u305f\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u6226\u7565<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d3\u30bf\u30df\u30f3D\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u3001\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u306e\u6700\u9069\u306a\u30d0\u30e9\u30f3\u30b9\u3092\u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u3066\u8abf\u6574\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u30b3\u30e9\u30fc\u30b2\u30f3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u6d3b\u7528\u3057\u3001\u9aa8\u306e\u5f37\u5ea6\u3092\u5411\u4e0a\u3002<\/strong><\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a\u9aa8\u5bc6\u5ea6\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3068\u907a\u4f1d\u5b50\uff08Nutrition Reviews\uff09<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>4. \u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u9aa8\u7c97\u3057\u3087\u3046\u75c7\uff1a\u74b0\u5883\u8981\u56e0\u3068\u907a\u4f1d\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/5080812_m-1024x683.jpg\" alt=\"\u5869\u30b5\u30d0\u5b9a\u98df\" class=\"wp-image-9733\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/5080812_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/5080812_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/5080812_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/5080812_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/5080812_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u30ea\u30b9\u30af\u306f\u3001\u5358\u306b\u907a\u4f1d\u5b50\u3060\u3051\u3067\u6c7a\u307e\u308b\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u74b0\u5883\u8981\u56e0\u304c\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u300c\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u300d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3082\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u98df\u4e8b\u3084\u904b\u52d5\u3001\u751f\u6d3b\u7fd2\u6163\u304c\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5909\u5316\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u9aa8\u5bc6\u5ea6\u306e\u7dad\u6301\u3084\u4f4e\u4e0b\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4-1. DNA\u30e1\u30c1\u30eb\u5316\u3068\u9aa8\u5bc6\u5ea6<\/strong><\/h3>\n\n\n\n<p>DNA\u30e1\u30c1\u30eb\u5316\u306f\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u6a5f\u69cb\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u9aa8\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>RUNX2\uff08\u8ee2\u5199\u56e0\u5b50\uff09\u907a\u4f1d\u5b50\u306e\u30e1\u30c1\u30eb\u5316<\/strong>\n<ul class=\"wp-block-list\">\n<li>RUNX2\u306f\u9aa8\u306e\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\u8ee2\u5199\u56e0\u5b50\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u30e1\u30c1\u30eb\u5316\u304c\u9032\u3080\u3068\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u4e0b\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30ab\u30eb\u30b7\u30a6\u30e0\u3084\u30d3\u30bf\u30df\u30f3K\u3092\u591a\u304f\u542b\u3080\u98df\u4e8b\u3092\u6442\u53d6\u3057\u3001RUNX2\u306e\u767a\u73fe\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1aDNA\u30e1\u30c1\u30eb\u5316\u3068\u9aa8\u5bc6\u5ea6\uff08Bone Journal\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4-2. \u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u3068\u9aa8\u5f62\u6210<\/strong><\/h3>\n\n\n\n<p>\u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\uff08\u30a2\u30bb\u30c1\u30eb\u5316\u3001\u30e1\u30c1\u30eb\u5316\u306a\u3069\uff09\u306f\u3001DNA\u306e\u5dfb\u304d\u4ed8\u304d\u5177\u5408\u3092\u5909\u5316\u3055\u305b\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>SIRT1\uff08\u30b5\u30fc\u30c1\u30e5\u30a4\u30f31\uff09\u907a\u4f1d\u5b50\u306e\u30a2\u30bb\u30c1\u30eb\u5316<\/strong>\n<ul class=\"wp-block-list\">\n<li>SIRT1\u306f\u9aa8\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\u907a\u4f1d\u5b50\u3092\u6d3b\u6027\u5316\u3057\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u3084\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff08\u8d64\u30ef\u30a4\u30f3\u3001\u7dd1\u8336\uff09\u3092\u542b\u3080\u98df\u4e8b\u304cSIRT1\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/onlinelibrary.wiley.com\/journal\/14749726\">SIRT1\u3068\u9aa8\u4ee3\u8b1d\uff08Aging Cell\uff09<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>5. \u8178\u5185\u7d30\u83cc\u3068\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u8178\u5185\u7d30\u83cc\uff08\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\uff09\u304c\u9aa8\u5bc6\u5ea6\u306e\u7dad\u6301\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u8178\u5185\u7d30\u83cc\u304c\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u5438\u53ce\u3092\u4fc3\u9032\u3057\u3001\u708e\u75c7\u3092\u6291\u3048\u308b\u3053\u3068\u3067\u9aa8\u306e\u5065\u5eb7\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5-1. \u8178\u5185\u7d30\u83cc\u3068\u30ab\u30eb\u30b7\u30a6\u30e0\u5438\u53ce<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FUT2\u907a\u4f1d\u5b50\u3068\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027<\/strong>\n<ul class=\"wp-block-list\">\n<li>FUT2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u3001\u8178\u5185\u306e\u5584\u7389\u83cc\uff08\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\u3001\u4e73\u9178\u83cc\uff09\u306e\u5272\u5408\u304c\u5909\u5316\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>FUT2\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u767a\u9175\u98df\u54c1\u3001\u30e8\u30fc\u30b0\u30eb\u30c8\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u9aa8\u5bc6\u5ea6\u3092\u7dad\u6301\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41564-019-0603-6\">\u8178\u5185\u7d30\u83cc\u3068\u30ab\u30eb\u30b7\u30a6\u30e0\u4ee3\u8b1d\uff08Nature Microbiology\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5-2. \u8178\u5185\u30d5\u30ed\u30fc\u30e9\u3068\u708e\u75c7\u5236\u5fa1<\/strong><\/h3>\n\n\n\n<p>\u6162\u6027\u7684\u306a\u708e\u75c7\u306f\u9aa8\u306e\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3092\u59a8\u3052\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u77ed\u9396\u8102\u80aa\u9178\uff08SCFA\uff09\u306e\u7523\u751f\u3068\u9aa8\u306e\u5065\u5eb7<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u8178\u5185\u7d30\u83cc\u304c\u767a\u9175\u3092\u884c\u3046\u3053\u3068\u3067\u77ed\u9396\u8102\u80aa\u9178\uff08\u9162\u9178\u3001\u916a\u9178\uff09\u304c\u751f\u6210\u3055\u308c\u3001\u708e\u75c7\u3092\u6291\u5236\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u98df\u7269\u7e4a\u7dad\uff08\u30aa\u30fc\u30c8\u30df\u30fc\u30eb\u3001\u91ce\u83dc\uff09\u3092\u6442\u53d6\u3057\u3001\u77ed\u9396\u8102\u80aa\u9178\u306e\u7523\u751f\u3092\u4fc3\u3059\u3053\u3068\u304c\u6709\u52b9\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a\u77ed\u9396\u8102\u80aa\u9178\u3068\u9aa8\u4ee3\u8b1d\uff08Journal of Endocrinology\uff09<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>6. \u30db\u30eb\u30e2\u30f3\u3068\u907a\u4f1d\u5b50\u306e\u76f8\u4e92\u4f5c\u7528\uff1a\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u8981\u56e0<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-1024x683.jpg\" alt=\"\u30bf\u30d6\u30ec\u30c3\u30c8\u3092\u64cd\u4f5c\u3059\u308b\u7537\u6027\u533b\u5e2b\" class=\"wp-image-9770\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30db\u30eb\u30e2\u30f3\u306f\u9aa8\u306e\u5065\u5eb7\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u7279\u306b\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3084\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\uff08PTH\uff09\u306f\u9aa8\u306e\u4ee3\u8b1d\u3092\u8abf\u7bc0\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6-1. ESR1\u907a\u4f1d\u5b50\u3068\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ESR1\uff08\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>ESR1\u907a\u4f1d\u5b50\u306e\u591a\u578b\u306f\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u4f5c\u7528\u3092\u5f37\u3081\u305f\u308a\u5f31\u3081\u305f\u308a\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u7279\u5b9a\u306e\u5909\u7570\uff08PvuII, XbaI\uff09\u3092\u6301\u3064\u5973\u6027\u306f\u3001\u9589\u7d4c\u5f8c\u306e\u9aa8\u5bc6\u5ea6\u4f4e\u4e0b\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u305f\u3081\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u88dc\u5145\u7642\u6cd5\uff08HRT\uff09\u306e\u9069\u5fdc\u3092\u8003\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1aESR1\u907a\u4f1d\u5b50\u3068\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\uff08Menopause Journal\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6-2. PTH\u907a\u4f1d\u5b50\u3068\u30ab\u30eb\u30b7\u30a6\u30e0\u8abf\u7bc0<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PTH\uff08\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>PTH\u306f\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u8840\u4e2d\u6fc3\u5ea6\u3092\u8abf\u6574\u3057\u3001\u9aa8\u5f62\u6210\u306b\u95a2\u4e0e\u3059\u308b\u3002\u907a\u4f1d\u7684\u5909\u7570\u306b\u3088\u3063\u3066\u3001PTH\u306e\u5206\u6ccc\u91cf\u304c\u7570\u306a\u308a\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>PTH\u306e\u904e\u5270\u5206\u6ccc\u578b\u306e\u4eba\u306f\u3001\u30ca\u30c8\u30ea\u30a6\u30e0\u306e\u6442\u53d6\u3092\u5236\u9650\u3057\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u6392\u51fa\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u91cd\u8981\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1aPTH\u3068\u9aa8\u4ee3\u8b1d\uff08Journal of Clinical Endocrinology &amp; Metabolism\uff09<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>7. \u672a\u6765\u306e\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u5bfe\u7b56\uff1a\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3068AI\u306e\u6d3b\u7528<\/strong><\/h2>\n\n\n\n<p>\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u3068\u4eba\u5de5\u77e5\u80fd\uff08AI\uff09\u306e\u767a\u5c55\u306b\u3088\u308a\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u7cbe\u5ea6\u304c\u5411\u4e0a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7-1. \u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u305f\u9aa8\u5bc6\u5ea6\u4e88\u6e2c<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AI\u3092\u6d3b\u7528\u3057\u305f\u30ea\u30b9\u30af\u8a55\u4fa1<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3068\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u60c5\u5831\u3092\u7d44\u307f\u5408\u308f\u305b\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3002<\/li>\n\n\n\n<li><strong>AI\u304c\u6700\u9069\u306a\u6804\u990a\u6226\u7565\u3084\u904b\u52d5\u30d7\u30e9\u30f3\u3092\u63d0\u6848\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/npjdigitalmed\">AI\u3068\u9aa8\u5bc6\u5ea6\u4e88\u6e2c\uff08npj Digital Medicine\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7-2. \u907a\u4f1d\u5b50\u6cbb\u7642\u3068\u9aa8\u518d\u751f<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CRISPR\u3092\u6d3b\u7528\u3057\u305f\u9aa8\u5f62\u6210\u4fc3\u9032\u907a\u4f1d\u5b50\u306e\u8abf\u6574<\/strong>\n<ul class=\"wp-block-list\">\n<li>LRP5\u3084RUNX2\u306e\u907a\u4f1d\u5b50\u7de8\u96c6\u306b\u3088\u308a\u3001\u9aa8\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\u6280\u8853\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1aCRISPR\u3068\u9aa8\u518d\u751f\uff08Trends in Biotechnology\uff09<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>8. \u9aa8\u7c97\u3057\u3087\u3046\u75c7\u3068\u907a\u4f1d\u5b50\u591a\u578b\uff1a\u30ea\u30b9\u30af\u8a55\u4fa1\u3068\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u533b\u7642<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/31198916_m-1024x585.jpg\" alt=\"\u907a\u4f1d\u5b50\u7814\u7a76\" class=\"wp-image-1167\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31198916_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31198916_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31198916_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31198916_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31198916_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u30ea\u30b9\u30af\u8a55\u4fa1\u306b\u306f\u3001\u5358\u4e00\u306e\u907a\u4f1d\u5b50\u3067\u306f\u306a\u304f\u3001\u8907\u6570\u306e\u907a\u4f1d\u5b50\u591a\u578b\u306e\u7d44\u307f\u5408\u308f\u305b\u304c\u5f71\u97ff\u3057\u307e\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff08PRS\uff09\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u3005\u4eba\u306e\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u30ea\u30b9\u30af\u3092\u3088\u308a\u6b63\u78ba\u306b\u4e88\u6e2c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8-1. \u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff08PRS\uff09\u3068\u306f\uff1f<\/strong><\/h3>\n\n\n\n<p>PRS\u306f\u3001\u6570\u5341\u304b\u3089\u6570\u767e\u306e\u907a\u4f1d\u5b50\u591a\u578b\u3092\u7d71\u5408\u3057\u3066\u3001\u7279\u5b9a\u306e\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3059\u308b\u624b\u6cd5\u3067\u3059\u3002\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u5834\u5408\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u907a\u4f1d\u5b50\u304cPRS\u306e\u8a08\u7b97\u306b\u7d44\u307f\u8fbc\u307e\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>VDR\uff08\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\uff09<\/strong>\uff1a\u30ab\u30eb\u30b7\u30a6\u30e0\u5438\u53ce\u306e\u8abf\u7bc0<\/li>\n\n\n\n<li><strong>COL1A1\uff08\u30b3\u30e9\u30fc\u30b2\u30f3I\u578b\u03b11\u9396\uff09<\/strong>\uff1a\u9aa8\u306e\u5f37\u5ea6\u3092\u6c7a\u5b9a<\/li>\n\n\n\n<li><strong>LRP5\uff08\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u53d7\u5bb9\u4f53\u95a2\u9023\u30bf\u30f3\u30d1\u30af5\uff09<\/strong>\uff1a\u9aa8\u5f62\u6210\u306e\u8abf\u7bc0<\/li>\n\n\n\n<li><strong>ESR1\uff08\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\uff09<\/strong>\uff1a\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306b\u3088\u308b\u9aa8\u4ee3\u8b1d\u306e\u5f71\u97ff<\/li>\n<\/ul>\n\n\n\n<p>PRS\u304c\u9ad8\u3044\u307b\u3069\u3001\u907a\u4f1d\u7684\u306b\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002\u3053\u306e\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u82e5\u5e74\u671f\u304b\u3089\u306e\u9aa8\u5bc6\u5ea6\u7ba1\u7406\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41467-020-19578-2\">\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\u3068\u9aa8\u7c97\u3057\u3087\u3046\u75c7\uff08Nature Communications\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8-2. PRS\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u533b\u7642<\/strong><\/h3>\n\n\n\n<p>PRS\u306e\u30c7\u30fc\u30bf\u3092\u57fa\u306b\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u500b\u5225\u5316\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u30ea\u30b9\u30af\u7fa4\uff08PRS\u304c\u9ad8\u3044\uff09<\/strong>\uff1a<br>\n<ul class=\"wp-block-list\">\n<li>\u82e5\u5e74\u671f\u304b\u3089\u306e\u30d3\u30bf\u30df\u30f3D\u30fb\u30ab\u30eb\u30b7\u30a6\u30e0\u88dc\u7d66\u3092\u5f37\u5316<\/li>\n\n\n\n<li>\u9ad8\u5f37\u5ea6\u306e\u8ca0\u8377\u3092\u304b\u3051\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08\u30a6\u30a7\u30a4\u30c8\u30ea\u30d5\u30c6\u30a3\u30f3\u30b0\uff09\u3092\u63a8\u5968<\/li>\n\n\n\n<li>\u5b9a\u671f\u7684\u306a\u9aa8\u5bc6\u5ea6\u691c\u67fb\uff08DXA\u30b9\u30ad\u30e3\u30f3\uff09\u3092\u5b9f\u65bd<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u4f4e\u30ea\u30b9\u30af\u7fa4\uff08PRS\u304c\u4f4e\u3044\uff09<\/strong>\uff1a<br>\n<ul class=\"wp-block-list\">\n<li>\u904e\u5270\u306a\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u6442\u53d6\u306e\u5fc5\u8981\u306f\u306a\u304f\u3001\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u98df\u4e8b\u3068\u904b\u52d5\u3067\u7ba1\u7406<\/li>\n\n\n\n<li>\u904b\u52d5\u306f\u30b9\u30c8\u30ec\u30c3\u30c1\u3084\u8efd\u3044\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u4e2d\u5fc3\u306b\u5b9f\u65bd<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.thelancet.com\/\">\u500b\u5225\u5316\u533b\u7642\u3068\u907a\u4f1d\u5b50\u691c\u67fb\uff08The Lancet\uff09<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>9. \u9aa8\u7c97\u3057\u3087\u3046\u75c7\u3068\u6804\u990a\uff1a\u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u6804\u990a\u6226\u7565<\/strong><\/h2>\n\n\n\n<p>\u9aa8\u306e\u5065\u5eb7\u306b\u306f\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u3084\u30d3\u30bf\u30df\u30f3D\u3060\u3051\u3067\u306a\u304f\u3001\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u3001\u4e9c\u925b\u3001\u30d3\u30bf\u30df\u30f3K2\u306a\u3069\u306e\u6804\u990a\u7d20\u3082\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u907a\u4f1d\u5b50\u578b\u306b\u3088\u3063\u3066\u3001\u305d\u308c\u3089\u306e\u6804\u990a\u7d20\u306e\u5438\u53ce\u7387\u3084\u4ee3\u8b1d\u80fd\u529b\u304c\u7570\u306a\u308b\u305f\u3081\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u6804\u990a\u6226\u7565\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9-1. \u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u4ee3\u8b1d\u3068TRPM6\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>TRPM6\uff08\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u8f38\u9001\u4f53\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong> \u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u306f\u9aa8\u306e\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u306b\u4e0d\u53ef\u6b20\u306a\u30df\u30cd\u30e9\u30eb\u3067\u3042\u308a\u3001TRPM6\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u5438\u53ce\u7387\u304c\u4f4e\u4e0b\u3059\u308b\u3002\n<ul class=\"wp-block-list\">\n<li><strong>TRPM6\u306e\u6d3b\u6027\u304c\u4f4e\u3044\u4eba\u306f\u3001\u30ca\u30c3\u30c4\u985e\u3001\u7dd1\u8449\u91ce\u83dc\u3001\u30d0\u30ca\u30ca\u306a\u3069\u306e\u98df\u54c1\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1aTRPM6\u3068\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\uff08Journal of Nutrition\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9-2. \u4e9c\u925b\u3068SLC39A5\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>SLC39A5\uff08\u4e9c\u925b\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong> \u4e9c\u925b\u306f\u9aa8\u306e\u6210\u9577\u3068\u4fee\u5fa9\u306b\u5fc5\u8981\u306a\u30df\u30cd\u30e9\u30eb\u3067\u3042\u308a\u3001SLC39A5\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u5438\u53ce\u52b9\u7387\u304c\u4f4e\u4e0b\u3059\u308b\u3002\n<ul class=\"wp-block-list\">\n<li><strong>SLC39A5\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u30ab\u30ad\u3084\u8d64\u8eab\u8089\u306a\u3069\u4e9c\u925b\u304c\u8c4a\u5bcc\u306a\u98df\u54c1\u3092\u6442\u53d6\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/onlinelibrary.wiley.com\/journal\/16134133\">SLC39A5\u3068\u9aa8\u5f62\u6210\uff08Molecular Nutrition &amp; Food Research\uff09<\/a><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>10. \u6700\u65b0\u306e\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u6cbb\u7642\u3068\u907a\u4f1d\u5b50\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"640\" height=\"447\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/2572508_s.jpg\" alt=\"DNA\" class=\"wp-image-1260\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2572508_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2572508_s-300x210.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure>\n\n\n\n<p>\u8fd1\u5e74\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u3082\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u8a66\u307f\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10-1. \u907a\u4f1d\u5b50\u6cbb\u7642\u3068\u9aa8\u5f62\u6210\u4fc3\u9032<\/strong><\/h3>\n\n\n\n<p>CRISPR-Cas9\u6280\u8853\u3092\u6d3b\u7528\u3057\u3001\u9aa8\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\u907a\u4f1d\u5b50\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30bf\u30fc\u30b2\u30c3\u30c8\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>LRP5<\/strong>\uff08\u9aa8\u5f62\u6210\u4fc3\u9032\uff09<\/li>\n\n\n\n<li><strong>SOST<\/strong>\uff08\u30b9\u30af\u30ec\u30ed\u30b9\u30c1\u30f3\u3001\u9aa8\u5438\u53ce\u6291\u5236\uff09<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/nbt\">CRISPR\u3068\u9aa8\u75be\u60a3\u6cbb\u7642\uff08Nature Biotechnology\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10-2. \u5e79\u7d30\u80de\u6cbb\u7642\u3068\u9aa8\u518d\u751f<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9593\u8449\u7cfb\u5e79\u7d30\u80de\uff08MSC\uff09\u3092\u7528\u3044\u305f\u9aa8\u518d\u751f\u6cbb\u7642<\/strong>\n<ul class=\"wp-block-list\">\n<li>MSC\u3092\u5229\u7528\u3057\u3066\u9aa8\u5f62\u6210\u3092\u4fc3\u9032\u3057\u3001\u9aa8\u5bc6\u5ea6\u3092\u56de\u5fa9\u3059\u308b\u8a66\u307f\u304c\u9032\u884c\u4e2d\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a\u5e79\u7d30\u80de\u6cbb\u7642\u3068\u9aa8\u518d\u751f\uff08Stem Cell Reports\uff09<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>11. \u9aa8\u7c97\u3057\u3087\u3046\u75c7\u4e88\u9632\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u666e\u53ca\u3068\u8ab2\u984c<\/strong><\/h2>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u30ea\u30b9\u30af\u8a55\u4fa1\u304c\u666e\u53ca\u3059\u308b\u4e00\u65b9\u3067\u3001\u502b\u7406\u7684\u30fb\u793e\u4f1a\u7684\u306a\u8ab2\u984c\u3082\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>11-1. \u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u306e\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u4fdd\u8b77<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u60c5\u5831\u306e\u7ba1\u7406\u3068\u7b2c\u4e09\u8005\u63d0\u4f9b\u30ea\u30b9\u30af<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u500b\u4eba\u306e\u907a\u4f1d\u60c5\u5831\u304c\u4fdd\u967a\u4f1a\u793e\u3084\u4f01\u696d\u306b\u4e0d\u9069\u5207\u306b\u5229\u7528\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u53b3\u683c\u306a\u7ba1\u7406\u304c\u5fc5\u8981\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a\u907a\u4f1d\u60c5\u5831\u306e\u502b\u7406\u3068\u6cd5\u898f\u5236\uff08Journal of Medical Ethics\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>11-2. \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u8cbb\u7528\u5bfe\u52b9\u679c<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u30b3\u30b9\u30c8\u3068\u5065\u5eb7\u4fdd\u967a\u9069\u7528\u306e\u8ab2\u984c<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u73fe\u5728\u306e\u3068\u3053\u308d\u3001\u9ad8\u7cbe\u5ea6\u306a\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u9ad8\u984d\u3067\u3042\u308a\u3001\u666e\u53ca\u306b\u306f\u3055\u3089\u306a\u308b\u30b3\u30b9\u30c8\u524a\u6e1b\u304c\u5fc5\u8981\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/onlinelibrary.wiley.com\/journal\/10991050\">\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u8cbb\u7528\u5bfe\u52b9\u679c\uff08Health Economics Journal\uff09<\/a><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>12. \u9aa8\u7c97\u3057\u3087\u3046\u75c7\u3068\u751f\u6d3b\u7fd2\u6163\uff1a\u907a\u4f1d\u5b50\u306b\u57fa\u3065\u3044\u305f\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"768\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/4615307_m-1024x768.jpg\" alt=\"\" class=\"wp-image-9946\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4615307_m-1024x768.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4615307_m-300x225.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4615307_m-768x576.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4615307_m-1536x1152.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4615307_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u4e88\u9632\u306b\u306f\u3001\u907a\u4f1d\u5b50\u306e\u5f71\u97ff\u3060\u3051\u3067\u306a\u304f\u3001\u751f\u6d3b\u7fd2\u6163\u304c\u5927\u304d\u304f\u95a2\u4e0e\u3057\u307e\u3059\u3002\u7279\u306b\u3001\u98df\u4e8b\u30fb\u904b\u52d5\u30fb\u7761\u7720\u30fb\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u306e4\u3064\u306e\u8981\u7d20\u304c\u3001\u9aa8\u5bc6\u5ea6\u306e\u7dad\u6301\u306b\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12-1. \u907a\u4f1d\u5b50\u578b\u306b\u57fa\u3065\u304f\u98df\u4e8b\u7fd2\u6163\u306e\u6700\u9069\u5316<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u3084\u30d3\u30bf\u30df\u30f3D\u306e\u5438\u53ce\u80fd\u529b\u304c\u7570\u306a\u308b\u305f\u3081\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u6804\u990a\u6226\u7565\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ab\u30eb\u30b7\u30a6\u30e0\u4ee3\u8b1d\u304c\u4f4e\u3044\u907a\u4f1d\u5b50\u578b\uff08VDR\u907a\u4f1d\u5b50\u5909\u7570\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4e73\u88fd\u54c1\u3001\u5c0f\u9b5a\u3001\u30ca\u30c3\u30c4\u985e\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3002<\/li>\n\n\n\n<li>\u30d3\u30bf\u30df\u30f3D\u3068\u4f75\u7528\u3057\u3066\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u5438\u53ce\u7387\u3092\u5411\u4e0a\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u6297\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5f31\u3044\u907a\u4f1d\u5b50\u578b\uff08SOD2\u907a\u4f1d\u5b50\u5909\u7570\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30d3\u30bf\u30df\u30f3C\u3084E\u3092\u591a\u304f\u542b\u3080\u98df\u54c1\uff08\u67d1\u6a58\u985e\u3001\u30ca\u30c3\u30c4\uff09\u3092\u6442\u53d6\u3002<\/li>\n\n\n\n<li>\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3092\u542b\u3080\u98df\u54c1\uff08\u7dd1\u8336\u3001\u30d6\u30eb\u30fc\u30d9\u30ea\u30fc\uff09\u3092\u53d6\u308a\u5165\u308c\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a\u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u6804\u990a\u6226\u7565\uff08Journal of Nutrition and Metabolism\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12-2. \u9aa8\u5bc6\u5ea6\u3092\u9ad8\u3081\u308b\u904b\u52d5\u30d7\u30ed\u30b0\u30e9\u30e0<\/strong><\/h3>\n\n\n\n<p>\u904b\u52d5\u306f\u9aa8\u3092\u5f37\u5316\u3059\u308b\u91cd\u8981\u306a\u8981\u7d20\u3067\u3059\u304c\u3001\u907a\u4f1d\u5b50\u578b\u306b\u3088\u3063\u3066\u52b9\u679c\u7684\u306a\u904b\u52d5\u304c\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>LRP5\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\uff08\u9aa8\u5f62\u6210\u304c\u5f31\u3044\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30a6\u30a7\u30a4\u30c8\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3084\u30b8\u30e3\u30f3\u30d7\u904b\u52d5\u3067\u9aa8\u306b\u523a\u6fc0\u3092\u4e0e\u3048\u308b\u3002<\/li>\n\n\n\n<li>\u9ad8\u8ca0\u8377\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08\u30b9\u30af\u30ef\u30c3\u30c8\u3001\u30c7\u30c3\u30c9\u30ea\u30d5\u30c8\uff09\u304c\u6709\u52b9\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>COL1A1\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\uff08\u976d\u5e2f\u304c\u5f31\u3044\uff09<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u904e\u5ea6\u306a\u885d\u6483\u3092\u907f\u3051\u3001\u30e8\u30ac\u3084\u6c34\u6cf3\u306a\u3069\u306e\u4f4e\u885d\u6483\u904b\u52d5\u3092\u53d6\u308a\u5165\u308c\u308b\u3002<\/li>\n\n\n\n<li>\u67d4\u8edf\u6027\u3092\u5411\u4e0a\u3055\u305b\u308b\u30b9\u30c8\u30ec\u30c3\u30c1\u3092\u7d99\u7d9a\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/onlinelibrary.wiley.com\/journal\/15234681\">\u904b\u52d5\u3068\u9aa8\u5bc6\u5ea6\uff08Journal of Bone and Mineral Research\uff09<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>13. \u9aa8\u7c97\u3057\u3087\u3046\u75c7\u3068\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u30db\u30eb\u30e2\u30f3\u306f\u9aa8\u5bc6\u5ea6\u306e\u8abf\u7bc0\u306b\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u7279\u306b\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3068\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u5f71\u97ff\u304c\u5927\u304d\u3044\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>13-1. \u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3068\u9aa8\u4ee3\u8b1d<\/strong><\/h3>\n\n\n\n<p>\u9589\u7d4c\u5f8c\u306e\u5973\u6027\u306f\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u5206\u6ccc\u304c\u4f4e\u4e0b\u3057\u3001\u9aa8\u5bc6\u5ea6\u304c\u6025\u6fc0\u306b\u6e1b\u5c11\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ESR1\u907a\u4f1d\u5b50\u3068\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u611f\u53d7\u6027<\/strong>\n<ul class=\"wp-block-list\">\n<li>ESR1\u306e\u7279\u5b9a\u306e\u591a\u578b\uff08PvuII, XbaI\uff09\u3092\u6301\u3064\u5973\u6027\u306f\u3001\u9589\u7d4c\u5f8c\u306e\u9aa8\u5bc6\u5ea6\u4f4e\u4e0b\u304c\u9855\u8457\u3002<\/li>\n\n\n\n<li>\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u88dc\u5145\u7642\u6cd5\uff08HRT\uff09\u306e\u9069\u5fdc\u3092\u691c\u8a0e\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3068\u9aa8\u5bc6\u5ea6\uff08Menopause Journal\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>13-2. \u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u3068\u9aa8\u5438\u53ce<\/strong><\/h3>\n\n\n\n<p>\u904e\u5270\u306a\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\uff08T3, T4\uff09\u306f\u9aa8\u5438\u53ce\u3092\u4fc3\u9032\u3057\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>DIO2\u907a\u4f1d\u5b50\u3068\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u4ee3\u8b1d<\/strong>\n<ul class=\"wp-block-list\">\n<li>DIO2\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u6d3b\u6027\u304c\u9ad8\u304f\u3001\u9aa8\u5438\u53ce\u304c\u52a0\u901f\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li>\u30e8\u30a6\u7d20\u6442\u53d6\u3092\u9069\u5207\u306b\u7ba1\u7406\u3057\u3001\u904e\u5270\u306a\u7532\u72b6\u817a\u523a\u6fc0\u3092\u9632\u3050\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u3068\u9aa8\u5bc6\u5ea6\uff08Thyroid Journal\uff09<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>14. \u9aa8\u7c97\u3057\u3087\u3046\u75c7\u3068\u6162\u6027\u708e\u75c7\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/02\/24702416_m-1024x683.jpg\" alt=\"\u819d\u75db\u307f\" class=\"wp-image-6933\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/24702416_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/24702416_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/24702416_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/24702416_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/02\/24702416_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u6162\u6027\u708e\u75c7\u306f\u9aa8\u306e\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3092\u59a8\u3052\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u907a\u4f1d\u7684\u306b\u708e\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba\u306f\u3001\u6297\u708e\u75c7\u5bfe\u7b56\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>14-1. \u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u9aa8\u4ee3\u8b1d<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IL6\u907a\u4f1d\u5b50\u3068\u708e\u75c7<\/strong>\n<ul class=\"wp-block-list\">\n<li>IL6\u306e\u591a\u578b\uff08rs1800795\uff09\u304c\u3042\u308b\u3068\u3001\u708e\u75c7\u30ec\u30d9\u30eb\u304c\u9ad8\u304f\u306a\u308a\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li>\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff08\u9752\u9b5a\u3001\u304f\u308b\u307f\uff09\u3092\u6442\u53d6\u3057\u3001\u708e\u75c7\u3092\u6291\u3048\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/articles\/ni\">IL6\u3068\u9aa8\u7c97\u3057\u3087\u3046\u75c7\uff08Nature Immunology\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>14-2. \u8178\u5185\u30d5\u30ed\u30fc\u30e9\u3068\u708e\u75c7\u5236\u5fa1<\/strong><\/h3>\n\n\n\n<p>\u8178\u5185\u74b0\u5883\u304c\u60aa\u5316\u3059\u308b\u3068\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u5897\u52a0\u3057\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3092\u4fc3\u9032\u3059\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u306e\u6d3b\u7528<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4e73\u9178\u83cc\u3001\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\u3092\u542b\u3080\u767a\u9175\u98df\u54c1\u3092\u6442\u53d6\u3057\u3001\u8178\u5185\u74b0\u5883\u3092\u6574\u3048\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u3068\u9aa8\u5bc6\u5ea6\uff08Gut Microbes Journal\uff09<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>15. \u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u305f\u672a\u6765\u306e\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u5bfe\u7b56<\/strong><\/h2>\n\n\n\n<p>AI\u3084\u30b2\u30ce\u30e0\u533b\u7642\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u5bfe\u7b56\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>15-1. AI\u306b\u3088\u308b\u9aa8\u5bc6\u5ea6\u30ea\u30b9\u30af\u8a55\u4fa1<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u00d7\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u00d7\u74b0\u5883\u30c7\u30fc\u30bf\u3092\u7d71\u5408<\/strong>\n<ul class=\"wp-block-list\">\n<li>AI\u304c\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u89e3\u6790\u3057\u3001\u6700\u9069\u306a\u6804\u990a\u30fb\u904b\u52d5\u30fb\u6cbb\u7642\u30d7\u30e9\u30f3\u3092\u63d0\u6848\u3002<\/li>\n\n\n\n<li>\u9aa8\u5bc6\u5ea6\u306e\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u76e3\u8996\u3068\u30ea\u30b9\u30af\u4e88\u6e2c\u304c\u53ef\u80fd\u306b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/npjdigitalmed\">AI\u3068\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u4e88\u6e2c\uff08npj Digital Medicine\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>15-2. \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3068\u9aa8\u5f62\u6210<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CRISPR\u6280\u8853\u3092\u7528\u3044\u305f\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u907a\u4f1d\u5b50\u6cbb\u7642<\/strong>\n<ul class=\"wp-block-list\">\n<li>LRP5\u3084RUNX2\u306e\u907a\u4f1d\u5b50\u7de8\u96c6\u306b\u3088\u308a\u3001\u9aa8\u5bc6\u5ea6\u3092\u6539\u5584\u3059\u308b\u6cbb\u7642\u6cd5\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1aCRISPR\u3068\u9aa8\u518d\u751f\uff08Trends in Biotechnology\uff09<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>16. \u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u65b0\u3057\u3044\u8a3a\u65ad\u6cd5\u3068\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u767a\u5c55<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/30532404_m-1024x683.jpg\" alt=\"\" class=\"wp-image-9777\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30532404_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30532404_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30532404_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30532404_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30532404_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7814\u7a76\u3068\u533b\u7642\u6280\u8853\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u8a3a\u65ad\u65b9\u6cd5\u3082\u9032\u5316\u3057\u3066\u3044\u307e\u3059\u3002\u5f93\u6765\u306eDXA\uff08\u30c7\u30e5\u30a2\u30ebX\u7dda\u5438\u53ce\u6e2c\u5b9a\u6cd5\uff09\u306b\u52a0\u3048\u3001AI\u3092\u6d3b\u7528\u3057\u305f\u907a\u4f1d\u5b50\u8a3a\u65ad\u3084\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u6e2c\u5b9a\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>16-1. AI\u3092\u6d3b\u7528\u3057\u305f\u753b\u50cf\u8a3a\u65ad<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AI\u306b\u3088\u308b\u9aa8\u5bc6\u5ea6\u8a55\u4fa1<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u9aa8\u5bc6\u5ea6\u6e2c\u5b9a\u88c5\u7f6e\uff08DXA\uff09\u3068AI\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u9aa8\u6298\u30ea\u30b9\u30af\u306e\u3088\u308a\u7cbe\u5bc6\u306a\u4e88\u6e2c\u304c\u53ef\u80fd\u306b\u3002<\/li>\n\n\n\n<li>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u7d71\u5408\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u4eba\u3054\u3068\u306e\u6700\u9069\u306a\u6cbb\u7642\u6cd5\u3092\u63d0\u6848\u3067\u304d\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/npjdigitalmed\">AI\u3068\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u8a3a\u65ad\uff08npj Digital Medicine\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>16-2. \u9aa8\u4ee3\u8b1d\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u6e2c\u5b9a<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8840\u6db2\u30fb\u5c3f\u691c\u67fb\u306b\u3088\u308b\u9aa8\u4ee3\u8b1d\u306e\u8a55\u4fa1<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>CTX\uff08C-\u30c6\u30ed\u30da\u30d7\u30c1\u30c9\uff09<\/strong>\uff1a\u9aa8\u5438\u53ce\u306e\u6307\u6a19<\/li>\n\n\n\n<li><strong>P1NP\uff08\u30a2\u30df\u30ce\u672b\u7aef\u30d7\u30ed\u30da\u30d7\u30c1\u30c9\uff09<\/strong>\uff1a\u9aa8\u5f62\u6210\u306e\u6307\u6a19<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3068\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u6e2c\u5b9a\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u6b63\u78ba\u306a\u30ea\u30b9\u30af\u8a55\u4fa1\u304c\u53ef\u80fd\u306b\u306a\u308a\u3001\u65e9\u671f\u4ecb\u5165\u304c\u5b9f\u73fe\u3059\u308b\u3002<\/p>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/onlinelibrary.wiley.com\/journal\/15234681\">\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u9aa8\u7c97\u3057\u3087\u3046\u75c7\uff08Journal of Bone and Mineral Research\uff09<\/a><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>17. \u907a\u4f1d\u5b50\u3068\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u5730\u57df\u5dee\uff1a\u4eba\u7a2e\u3084\u6c11\u65cf\u306b\u3088\u308b\u9055\u3044<\/strong><\/h2>\n\n\n\n<p>\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u52a0\u3048\u3066\u3001\u4eba\u7a2e\u3084\u6c11\u65cf\u306b\u3088\u308b\u9055\u3044\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u591a\u578b\u306e\u5206\u5e03\u306b\u306f\u5730\u57df\u5dee\u304c\u3042\u308a\u3001\u305d\u308c\u304c\u9aa8\u5bc6\u5ea6\u306e\u9055\u3044\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>17-1. \u4eba\u7a2e\u3054\u3068\u306e\u9aa8\u5bc6\u5ea6\u306e\u9055\u3044\u3068\u907a\u4f1d\u7684\u80cc\u666f<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30a2\u30b8\u30a2\u7cfb<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>VDR\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u5909\u7570\uff08TaqI\u591a\u578b\uff09\u304c\u9ad8\u983b\u5ea6\u3067\u898b\u3089\u308c\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u5438\u53ce\u304c\u4f4e\u3044\u50be\u5411\u306b\u3042\u308b\u3002<\/li>\n\n\n\n<li>\u4e73\u88fd\u54c1\u3092\u3042\u307e\u308a\u6442\u53d6\u3057\u306a\u3044\u6587\u5316\u7684\u80cc\u666f\u3082\u5f71\u97ff\u3057\u3001\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u3081\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30e8\u30fc\u30ed\u30c3\u30d1\u7cfb<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>COL1A1\u907a\u4f1d\u5b50\u306e\u5909\u7570\uff08Sp1\u591a\u578b\uff09\u306e\u5272\u5408\u304c\u9ad8\u304f\u3001\u9aa8\u306e\u5f37\u5ea6\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li>\u4e73\u88fd\u54c1\u306e\u6442\u53d6\u304c\u591a\u3044\u305f\u3081\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u4f9b\u7d66\u306f\u5341\u5206\u3060\u304c\u3001\u65e5\u7167\u91cf\u304c\u5c11\u306a\u3044\u5730\u57df\u3067\u306f\u30d3\u30bf\u30df\u30f3D\u4e0d\u8db3\u306b\u306a\u308a\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30a2\u30d5\u30ea\u30ab\u7cfb<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u9aa8\u5bc6\u5ea6\u304c\u9ad8\u304f\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u767a\u75c7\u7387\u306f\u6bd4\u8f03\u7684\u4f4e\u3044\u3002<\/li>\n\n\n\n<li>LRP5\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u591a\u578b\u304c\u9aa8\u91cf\u7dad\u6301\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.springer.com\/journal\/198\">\u9aa8\u5bc6\u5ea6\u3068\u4eba\u7a2e\u5dee\uff08Osteoporosis International\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>17-2. \u5730\u57df\u5dee\u3092\u8003\u616e\u3057\u305f\u4e88\u9632\u6226\u7565<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30a2\u30b8\u30a2\u7cfb\u306e\u5bfe\u7b56<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30d3\u30bf\u30df\u30f3D\u306e\u6442\u53d6\u91cf\u3092\u5897\u3084\u3057\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u5438\u53ce\u3092\u4fc3\u9032\u3002<\/li>\n\n\n\n<li>\u65e5\u5149\u6d74\u306e\u6642\u9593\u3092\u5897\u3084\u3057\u3001\u4f53\u5185\u306e\u30d3\u30bf\u30df\u30f3D\u5408\u6210\u3092\u4fc3\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30e8\u30fc\u30ed\u30c3\u30d1\u7cfb\u306e\u5bfe\u7b56<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u51ac\u5b63\u306b\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u6d3b\u7528\u3057\u3001\u65e5\u7167\u4e0d\u8db3\u306b\u3088\u308b\u9aa8\u5bc6\u5ea6\u4f4e\u4e0b\u3092\u9632\u3050\u3002<\/li>\n\n\n\n<li>\u9aa8\u5bc6\u5ea6\u691c\u67fb\u306e\u983b\u5ea6\u3092\u5897\u3084\u3057\u3001\u65e9\u671f\u767a\u898b\u3092\u91cd\u8996\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30a2\u30d5\u30ea\u30ab\u7cfb\u306e\u5bfe\u7b56<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u904b\u52d5\u7fd2\u6163\u3092\u7dad\u6301\u3057\u3001\u52a0\u9f62\u306b\u3088\u308b\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3092\u6291\u3048\u308b\u3002<\/li>\n\n\n\n<li>\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u6442\u53d6\u91cf\u304c\u4f4e\u3044\u5834\u5408\u306f\u3001\u4e73\u88fd\u54c1\u3084\u5c0f\u9b5a\u306e\u6442\u53d6\u3092\u5897\u3084\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a\u907a\u4f1d\u3068\u6804\u990a\u306e\u5730\u57df\u5dee\uff08American Journal of Clinical Nutrition\uff09<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 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