{"id":9954,"date":"2025-03-12T08:18:36","date_gmt":"2025-03-12T08:18:36","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=9954"},"modified":"2025-03-12T08:18:38","modified_gmt":"2025-03-12T08:18:38","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e8%80%81%e5%8c%96%e9%80%9f%e5%ba%a6%ef%bc%9a%e7%a7%91%e5%ad%a6%e3%81%8c%e7%a4%ba%e3%81%99%e8%80%81%e5%8c%96%e9%98%b2%e6%ad%a2%e7%ad%96","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e8%80%81%e5%8c%96%e9%80%9f%e5%ba%a6%ef%bc%9a%e7%a7%91%e5%ad%a6%e3%81%8c%e7%a4%ba%e3%81%99%e8%80%81%e5%8c%96%e9%98%b2%e6%ad%a2%e7%ad%96\/","title":{"rendered":"\u907a\u4f1d\u5b50\u3068\u8001\u5316\u901f\u5ea6\uff1a\u79d1\u5b66\u304c\u793a\u3059\u8001\u5316\u9632\u6b62\u7b56"},"content":{"rendered":"\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u306f\u3058\u3081\u306b<\/strong><\/h2>\n\n\n\n<p>\u8001\u5316\u306f\u4e0d\u53ef\u907f\u306e\u751f\u7269\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u3067\u3059\u304c\u3001\u305d\u306e\u9032\u884c\u901f\u5ea6\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u9055\u3044\u3092\u751f\u307f\u51fa\u3059\u4e3b\u306a\u8981\u56e0\u306e\u4e00\u3064\u304c\u300c\u907a\u4f1d\u5b50\u300d\u3067\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u8001\u5316\u306e\u901f\u5ea6\u3092\u6c7a\u5b9a\u3057\u3001\u3055\u3089\u306b\u74b0\u5883\u8981\u56e0\u3084\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u304c\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u7814\u7a76\u306b\u3088\u3063\u3066\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u672c\u8a18\u4e8b\u3067\u306f\u3001\u8001\u5316\u306b\u95a2\u4e0e\u3059\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50\u3068\u3001\u305d\u308c\u3092\u57fa\u306b\u3057\u305f\u79d1\u5b66\u7684\u306a\u8001\u5316\u9632\u6b62\u7b56\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>1. \u8001\u5316\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/h2>\n\n\n\n<p>\u8001\u5316\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u306f\u3001\u7d30\u80de\u306e\u4fee\u5fa9\u6a5f\u80fd\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3001\u30c6\u30ed\u30e1\u30a2\u306e\u9577\u3055\u3001DNA\u4fee\u5fa9\u80fd\u529b\u306a\u3069\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u5236\u5fa1\u3059\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1-1. SIRT\u907a\u4f1d\u5b50\u3068\u9577\u5bff<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>SIRT1\uff08\u30b5\u30fc\u30c1\u30e5\u30a4\u30f31\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>SIRT1\u306f\u7d30\u80de\u306e\u8001\u5316\u3092\u6291\u5236\u3057\u3001DNA\u4fee\u5fa9\u3084\u6297\u708e\u75c7\u4f5c\u7528\u3092\u6301\u3064\u3002<\/li>\n\n\n\n<li>\u9577\u5bff\u3092\u793a\u3059\u52d5\u7269\u3084\u4eba\u9593\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001SIRT1\u306e\u767a\u73fe\u304c\u9ad8\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\uff08\u8d64\u30ef\u30a4\u30f3\u3084\u30d6\u30c9\u30a6\u306b\u542b\u307e\u308c\u308b\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff09\u304cSIRT1\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/articles\/nrm\">SIRT1\u3068\u8001\u5316\u306e\u7814\u7a76\uff08Nature Reviews Molecular Cell Biology\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1-2. FOXO\u907a\u4f1d\u5b50\u3068\u6297\u9178\u5316\u9632\u5fa1<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FOXO3\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>FOXO3\u306f\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3092\u9ad8\u3081\u3001\u7d30\u80de\u306e\u751f\u5b58\u7387\u3092\u5411\u4e0a\u3055\u305b\u308b\u3002<\/li>\n\n\n\n<li>\u9577\u5bff\u306e\u4eba\u3005\u306b\u306f\u3001\u7279\u5b9a\u306eFOXO3\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u5272\u5408\u304c\u9ad8\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u65ad\u98df\uff08\u30d5\u30a1\u30b9\u30c6\u30a3\u30f3\u30b0\uff09\u3084\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u304cFOXO3\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1aFOXO3\u3068\u9577\u5bff\u306e\u95a2\u4fc2\uff08Cell Metabolism\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1-3. TERT\u907a\u4f1d\u5b50\u3068\u30c6\u30ed\u30e1\u30a2\u306e\u9577\u3055<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>TERT\uff08\u30c6\u30ed\u30e1\u30e9\u30fc\u30bc\u9006\u8ee2\u5199\u9175\u7d20\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>TERT\u306f\u30c6\u30ed\u30e1\u30a2\u3092\u4fee\u5fa9\u3057\u3001\u7d30\u80de\u306e\u5bff\u547d\u3092\u5ef6\u3070\u3059\u3002<\/li>\n\n\n\n<li>\u907a\u4f1d\u7684\u306bTERT\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u4eba\u306f\u3001\u8001\u5316\u901f\u5ea6\u304c\u9045\u3044\u50be\u5411\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u904b\u52d5\u3084\u7791\u60f3\u304c\u30c6\u30ed\u30e1\u30a2\u306e\u77ed\u7e2e\u3092\u6291\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/articles\/ng\">TERT\u3068\u8001\u5316\u306e\u7814\u7a76\uff08Nature Genetics\uff09<\/a><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. \u907a\u4f1d\u5b50\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-1024x585.jpg\" alt=\"\" class=\"wp-image-9460\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u8001\u5316\u306e\u52a0\u901f\u8981\u56e0\u306e\u4e00\u3064\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u306e\u84c4\u7a4d\u304c\u7d30\u80de\u3092\u50b7\u3064\u3051\u3001\u8001\u5316\u306e\u9032\u884c\u3092\u4fc3\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2-1. SOD2\u907a\u4f1d\u5b50\u3068\u6297\u9178\u5316\u6a5f\u80fd<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>SOD2\uff08\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u30c7\u30a3\u30b9\u30e0\u30bf\u30fc\u30bc2\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>SOD2\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u3067\u767a\u751f\u3059\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u6291\u3048\u308b\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3059\u308b\u3002<\/li>\n\n\n\n<li>SOD2\u306e\u6d3b\u6027\u304c\u4f4e\u3044\u4eba\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u8001\u5316\u304c\u9032\u884c\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u30d3\u30bf\u30df\u30f3C\u3084E\u3001\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3092\u542b\u3080\u98df\u54c1\u3092\u6442\u53d6\u3059\u308b\u3068\u3001SOD2\u306e\u6a5f\u80fd\u3092\u88dc\u52a9\u3067\u304d\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.sciencedirect.com\/journal\/free-radical-biology-and-medicine\">SOD2\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\uff08Free Radical Biology &amp; Medicine\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2-2. GPX1\u907a\u4f1d\u5b50\u3068\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u30b7\u30b9\u30c6\u30e0<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>GPX1\uff08\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u30da\u30eb\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc1\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>GPX1\u306f\u7d30\u80de\u306e\u6297\u9178\u5316\u9632\u5fa1\u3092\u62c5\u3044\u3001\u8001\u5316\u3092\u6291\u5236\u3059\u308b\u5f79\u5272\u3092\u6301\u3064\u3002<\/li>\n\n\n\n<li>GPX1\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u52a0\u9f62\u95a2\u9023\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30bb\u30ec\u30f3\uff08\u30d6\u30e9\u30b8\u30eb\u30ca\u30c3\u30c4\u3001\u9b5a\u4ecb\u985e\uff09\u3092\u6442\u53d6\u3059\u308b\u3068\u3001GPX1\u306e\u6a5f\u80fd\u304c\u5411\u4e0a\u3059\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1aGPX1\u3068\u8001\u5316\u306e\u95a2\u4fc2\uff08Biochemical Journal\uff09<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u907a\u4f1d\u5b50\u306b\u57fa\u3065\u304f\u8001\u5316\u9632\u6b62\u7b56<\/strong><\/h2>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7814\u7a76\u306b\u57fa\u3065\u3044\u305f\u79d1\u5b66\u7684\u306a\u8001\u5316\u9632\u6b62\u7b56\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3-1. \u6804\u990a\u6226\u7565<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>SIRT1\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u98df\u54c1<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\uff08\u8d64\u30ef\u30a4\u30f3\u3001\u30d6\u30c9\u30a6\uff09<\/li>\n\n\n\n<li>\u30b1\u30eb\u30bb\u30c1\u30f3\uff08\u7389\u306d\u304e\u3001\u30ea\u30f3\u30b4\uff09<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u6297\u9178\u5316\u4f5c\u7528\u3092\u5f37\u5316\u3059\u308b\u98df\u54c1<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30d3\u30bf\u30df\u30f3C\uff08\u67d1\u6a58\u985e\u3001\u30ad\u30a6\u30a4\uff09<\/li>\n\n\n\n<li>\u30d3\u30bf\u30df\u30f3E\uff08\u30ca\u30c3\u30c4\u985e\u3001\u30a2\u30dc\u30ab\u30c9\uff09<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a\u6804\u990a\u3068\u8001\u5316\u306e\u95a2\u4fc2\uff08Journal of Nutrition\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3-2. \u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u6226\u7565<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u904b\u52d5<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u6709\u9178\u7d20\u904b\u52d5\u304c\u30c6\u30ed\u30e1\u30a2\u306e\u77ed\u7e2e\u3092\u6291\u3048\u308b\u3002<\/li>\n\n\n\n<li>\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u3092\u5411\u4e0a\u3055\u305b\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7791\u60f3\u3084\u30e8\u30ac\u304cFOXO3\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3002<\/li>\n\n\n\n<li>\u826f\u8cea\u306a\u7761\u7720\u304cDNA\u4fee\u5fa9\u3092\u4fc3\u9032\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a\u904b\u52d5\u3068\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u7814\u7a76\uff08Medicine &amp; Science in Sports &amp; Exercise\uff09<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>4. \u30c6\u30ed\u30e1\u30a2\u3068\u907a\u4f1d\u5b50\uff1a\u7d30\u80de\u306e\u5bff\u547d\u3092\u6c7a\u3081\u308b\u8981\u56e0<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"771\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31862647_m-1024x771.jpg\" alt=\"\" class=\"wp-image-9962\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31862647_m-1024x771.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31862647_m-300x226.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31862647_m-768x578.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31862647_m-1536x1157.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31862647_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30c6\u30ed\u30e1\u30a2\u306f\u67d3\u8272\u4f53\u306e\u672b\u7aef\u306b\u3042\u308bDNA\u306e\u7e70\u308a\u8fd4\u3057\u914d\u5217\u3067\u3001\u7d30\u80de\u5206\u88c2\u306e\u305f\u3073\u306b\u77ed\u7e2e\u3057\u3066\u3044\u304d\u307e\u3059\u3002\u30c6\u30ed\u30e1\u30a2\u304c\u77ed\u304f\u306a\u308a\u3059\u304e\u308b\u3068\u7d30\u80de\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u8001\u5316\u304c\u9032\u884c\u3057\u307e\u3059\u3002\u907a\u4f1d\u5b50\u306f\u30c6\u30ed\u30e1\u30a2\u306e\u7dad\u6301\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u591a\u578b\u304c\u8001\u5316\u901f\u5ea6\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4-1. TERC\u907a\u4f1d\u5b50\u3068\u30c6\u30ed\u30e1\u30a2\u9577\u306e\u7dad\u6301<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>TERC\uff08\u30c6\u30ed\u30e1\u30e9\u30fc\u30bcRNA\u30b3\u30f3\u30dd\u30fc\u30cd\u30f3\u30c8\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>TERC\u306f\u30c6\u30ed\u30e1\u30a2\u306e\u4fee\u5fa9\u3092\u62c5\u3046\u9175\u7d20\u300c\u30c6\u30ed\u30e1\u30e9\u30fc\u30bc\u300d\u306e\u6d3b\u6027\u306b\u95a2\u4e0e\u3059\u308b\u3002<\/li>\n\n\n\n<li>TERC\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u30c6\u30ed\u30e1\u30a2\u306e\u77ed\u7e2e\u304c\u52a0\u901f\u3057\u3001\u8001\u5316\u304c\u9032\u884c\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff08\u30b5\u30fc\u30e2\u30f3\u3001\u30c1\u30a2\u30b7\u30fc\u30c9\uff09\u304c\u30c6\u30ed\u30e1\u30a2\u77ed\u7e2e\u3092\u6291\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13602-9\">TERC\u3068\u30c6\u30ed\u30e1\u30a2\u9577\uff08Nature Communications\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4-2. WRN\u907a\u4f1d\u5b50\u3068DNA\u4fee\u5fa9<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>WRN\uff08\u30ef\u30fc\u30ca\u30fc\u75c7\u5019\u7fa4\u907a\u4f1d\u5b50\uff09<\/strong>\n<ul class=\"wp-block-list\">\n<li>WRN\u306fDNA\u4fee\u5fa9\u306b\u95a2\u4e0e\u3057\u3001\u5909\u7570\u304c\u3042\u308b\u3068\u65e9\u8001\u75c7\uff08\u30ef\u30fc\u30ca\u30fc\u75c7\u5019\u7fa4\uff09\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002<\/li>\n\n\n\n<li>WRN\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u304c\u4f4e\u3044\u3068\u3001\u7d30\u80de\u306e\u4fee\u5fa9\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u3001\u8001\u5316\u304c\u52a0\u901f\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff08\u7dd1\u8336\u3001\u30c0\u30fc\u30af\u30c1\u30e7\u30b3\u30ec\u30fc\u30c8\uff09\u3092\u6442\u53d6\u3059\u308b\u3068\u3001DNA\u4fee\u5fa9\u6a5f\u80fd\u3092\u30b5\u30dd\u30fc\u30c8\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/onlinelibrary.wiley.com\/journal\/14749726\">WRN\u907a\u4f1d\u5b50\u3068\u8001\u5316\uff08Aging Cell\uff09<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>5. \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\uff1a\u8001\u5316\u306e\u9375\u3092\u63e1\u308b\u7d30\u80de\u306e\u767a\u96fb\u6240<\/strong><\/h2>\n\n\n\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u751f\u7523\u3059\u308b\u300c\u767a\u96fb\u6240\u300d\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u304c\u3001\u52a0\u9f62\u3068\u3068\u3082\u306b\u305d\u306e\u52b9\u7387\u304c\u4f4e\u4e0b\u3057\u307e\u3059\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u3092\u5236\u5fa1\u3059\u308b\u907a\u4f1d\u5b50\u304c\u8001\u5316\u306e\u901f\u5ea6\u3092\u5de6\u53f3\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5-1. PGC-1\u03b1\u907a\u4f1d\u5b50\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6d3b\u6027<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PPARGC1A\uff08PGC-1\u03b1\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>PGC-1\u03b1\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u65b0\u751f\u3092\u4fc3\u9032\u3057\u3001\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u8abf\u6574\u3059\u308b\u3002<\/li>\n\n\n\n<li>\u9ad8PGC-1\u03b1\u578b\u306e\u4eba\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u304c\u7dad\u6301\u3055\u308c\u3084\u3059\u304f\u3001\u8001\u5316\u304c\u9045\u3044\u3002<\/li>\n\n\n\n<li><strong>\u6709\u9178\u7d20\u904b\u52d5\u304cPGC-1\u03b1\u306e\u767a\u73fe\u3092\u9ad8\u3081\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/physoc.onlinelibrary.wiley.com\/\">PGC-1\u03b1\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\uff08Journal of Physiology\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5-2. TFAM\u907a\u4f1d\u5b50\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u4fee\u5fa9<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>TFAM\uff08\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u8ee2\u5199\u56e0\u5b50A\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>TFAM\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u306e\u4fee\u5fa9\u3068\u8907\u88fd\u306b\u95a2\u4e0e\u3057\u3001\u305d\u306e\u6a5f\u80fd\u304c\u4f4e\u3044\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u304c\u4f4e\u4e0b\u3057\u3001\u8001\u5316\u304c\u52a0\u901f\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0Q10\uff08\u9752\u9b5a\u3001\u30ca\u30c3\u30c4\uff09\u3092\u6442\u53d6\u3059\u308b\u3068\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5065\u5eb7\u3092\u30b5\u30dd\u30fc\u30c8\u3067\u304d\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1aTFAM\u3068\u8001\u5316\uff08Cell Metabolism\uff09<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>6. \u907a\u4f1d\u5b50\u3068\u514d\u75ab\u8001\u5316\uff1a\u52a0\u9f62\u306b\u3088\u308b\u514d\u75ab\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3092\u9632\u3050<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/3377385_m-1024x683.jpg\" alt=\"\" class=\"wp-image-9900\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3377385_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3377385_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3377385_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3377385_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3377385_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u52a0\u9f62\u306b\u4f34\u3044\u3001\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u50cd\u304d\u304c\u4f4e\u4e0b\u3057\u3001\u611f\u67d3\u75c7\u3084\u6162\u6027\u708e\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002\u3053\u306e\u514d\u75ab\u8001\u5316\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u304c\u7279\u5b9a\u3055\u308c\u3066\u304a\u308a\u3001\u9069\u5207\u306a\u5bfe\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u3067\u514d\u75ab\u6a5f\u80fd\u3092\u7dad\u6301\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6-1. IL6\u907a\u4f1d\u5b50\u3068\u708e\u75c7\u5236\u5fa1<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IL6\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f36\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>IL6\u306f\u708e\u75c7\u3092\u4fc3\u9032\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308a\u3001\u52a0\u9f62\u3068\u3068\u3082\u306b\u305d\u306e\u30ec\u30d9\u30eb\u304c\u4e0a\u6607\u3059\u308b\u3002<\/li>\n\n\n\n<li>IL6\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u6162\u6027\u708e\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u3001\u8001\u5316\u304c\u52a0\u901f\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff08EPA\u30fbDHA\uff09\u304cIL6\u306e\u904e\u5270\u306a\u5206\u6ccc\u3092\u6291\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/articles\/ni\">IL6\u3068\u514d\u75ab\u8001\u5316\uff08Nature Immunology\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6-2. KLOTHO\u907a\u4f1d\u5b50\u3068\u9577\u5bff<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>KLOTHO\uff08\u30af\u30ed\u30c8\u30fc\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>KLOTHO\u306f\u6297\u708e\u75c7\u4f5c\u7528\u3092\u6301\u3061\u3001\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u5f79\u5272\u3092\u679c\u305f\u3059\u3002<\/li>\n\n\n\n<li>KLOTHO\u306e\u767a\u73fe\u304c\u4f4e\u3044\u3068\u3001\u514d\u75ab\u8001\u5316\u304c\u9032\u307f\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u65ad\u98df\uff08\u30a4\u30f3\u30bf\u30fc\u30df\u30c3\u30c6\u30f3\u30c8\u30fb\u30d5\u30a1\u30b9\u30c6\u30a3\u30f3\u30b0\uff09\u304cKLOTHO\u306e\u767a\u73fe\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.sciencedirect.com\/journal\/aging-research-reviews\">KLOTHO\u3068\u8001\u5316\u306e\u7814\u7a76\uff08Aging Research Reviews\uff09<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>7. \u907a\u4f1d\u5b50\u3092\u6d3b\u7528\u3057\u305f\u672a\u6765\u306e\u8001\u5316\u9632\u6b62\u6280\u8853<\/strong><\/h2>\n\n\n\n<p>\u8fd1\u5e74\u3001\u8001\u5316\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306e\u7814\u7a76\u304c\u9032\u307f\u3001\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3084AI\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u533b\u7642\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7-1. CRISPR\u6280\u8853\u3092\u6d3b\u7528\u3057\u305f\u8001\u5316\u9045\u5ef6<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8001\u5316\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u6539\u5909<\/strong>\n<ul class=\"wp-block-list\">\n<li>CRISPR\u3092\u7528\u3044\u3066TERT\u3084SIRT1\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u3001\u8001\u5316\u901f\u5ea6\u3092\u9045\u3089\u305b\u308b\u8a66\u307f\u304c\u9032\u884c\u4e2d\u3002<\/li>\n\n\n\n<li><strong>\u502b\u7406\u7684\u8ab2\u984c\u3082\u3042\u308b\u305f\u3081\u3001\u614e\u91cd\u306a\u691c\u8a0e\u304c\u5fc5\u8981\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1aCRISPR\u3068\u8001\u5316\u7814\u7a76\uff08Trends in Genetics\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7-2. AI\u3068\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u500b\u5225\u5316\u533b\u7642<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u57fa\u306b\u6700\u9069\u306a\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u6226\u7565\u3092\u63d0\u6848<\/strong>\n<ul class=\"wp-block-list\">\n<li>AI\u304c\u98df\u4e8b\u3001\u904b\u52d5\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6700\u9069\u306a\u7d44\u307f\u5408\u308f\u305b\u3092\u89e3\u6790\u3002<\/li>\n\n\n\n<li><strong>\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u5065\u5eb7\u72b6\u614b\u3092\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3057\u3001\u8001\u5316\u306e\u9032\u884c\u3092\u4e88\u6e2c\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/npjdigitalmed\">AI\u3068\u500b\u5225\u5316\u533b\u7642\uff08npj Digital Medicine\uff09<\/a><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>8. \u907a\u4f1d\u5b50\u3068\u8a8d\u77e5\u6a5f\u80fd\u306e\u8001\u5316\uff1a\u8133\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u30ab\u30ae<\/strong><\/h2>\n\n\n\n<p>\u8001\u5316\u306f\u8133\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u8a18\u61b6\u529b\u3084\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306a\u3069\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u307e\u3059\u3002\u907a\u4f1d\u5b50\u7814\u7a76\u306b\u3088\u308a\u3001\u8a8d\u77e5\u6a5f\u80fd\u306e\u8001\u5316\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u304c\u7279\u5b9a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u3092\u8003\u616e\u3057\u305f\u5bfe\u7b56\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8-1. APOE\u907a\u4f1d\u5b50\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u30ea\u30b9\u30af<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>APOE\uff08\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30afE\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>APOE\u306f\u8102\u8cea\u306e\u4ee3\u8b1d\u3068\u795e\u7d4c\u7d30\u80de\u306e\u4fee\u5fa9\u306b\u95a2\u4e0e\u3057\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3002<\/li>\n\n\n\n<li><strong>APOE \u03b54\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u308b\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u5730\u4e2d\u6d77\u5f0f\u98df\u4e8b\uff08\u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u3001\u30ca\u30c3\u30c4\u3001\u9752\u9b5a\uff09\u304cAPOE \u03b54\u578b\u306e\u5f71\u97ff\u3092\u8efd\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/neuro\/\">APOE\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08Nature Neuroscience\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8-2. BDNF\u907a\u4f1d\u5b50\u3068\u8133\u306e\u53ef\u5851\u6027<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>BDNF\uff08\u8133\u7531\u6765\u795e\u7d4c\u6804\u990a\u56e0\u5b50\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>BDNF\u306f\u795e\u7d4c\u7d30\u80de\u306e\u6210\u9577\u3068\u30b7\u30ca\u30d7\u30b9\u306e\u5f62\u6210\u3092\u4fc3\u9032\u3057\u3001\u5b66\u7fd2\u3084\u8a18\u61b6\u529b\u3092\u652f\u3048\u308b\u3002<\/li>\n\n\n\n<li>BDNF\u306e\u7279\u5b9a\u306e\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u52a0\u9f62\u306b\u3088\u308b\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u6709\u9178\u7d20\u904b\u52d5\uff08\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0\u3001\u30b8\u30e7\u30ae\u30f3\u30b0\uff09\u304cBDNF\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3057\u3001\u8133\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1aBDNF\u3068\u8a8d\u77e5\u6a5f\u80fd\uff08Neuron\uff09<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>9. \u907a\u4f1d\u5b50\u3068\u7b4b\u8089\u306e\u8001\u5316\uff1a\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u306e\u4e88\u9632\u7b56<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31033284_m-1024x683.jpg\" alt=\"PC\u3067\u4f5c\u696d\u3059\u308b\u533b\u7642\u5f93\u4e8b\u8005\" class=\"wp-image-9562\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31033284_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31033284_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31033284_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31033284_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31033284_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u52a0\u9f62\u3068\u3068\u3082\u306b\u7b4b\u8089\u91cf\u304c\u6e1b\u5c11\u3059\u308b\u300c\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u300d\u306f\u3001\u904b\u52d5\u80fd\u529b\u306e\u4f4e\u4e0b\u3084\u8ee2\u5012\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3092\u62db\u304d\u307e\u3059\u3002\u7b4b\u8089\u306e\u8001\u5316\u306b\u306f\u907a\u4f1d\u7684\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u9069\u5207\u306a\u5bfe\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u3067\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9-1. MSTN\u907a\u4f1d\u5b50\u3068\u7b4b\u8089\u91cf\u306e\u7dad\u6301<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MSTN\uff08\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>MSTN\u306f\u7b4b\u8089\u306e\u6210\u9577\u3092\u6291\u5236\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u3068\u7b4b\u8089\u306e\u767a\u9054\u304c\u6291\u3048\u3089\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>MSTN\u306e\u7279\u5b9a\u306e\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u7b4b\u8089\u91cf\u306e\u6e1b\u5c11\u304c\u52a0\u901f\u3057\u3084\u3059\u3044\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08\u30a6\u30a7\u30a4\u30c8\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff09\u304cMSTN\u306e\u6291\u5236\u306b\u52b9\u679c\u7684\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1aMSTN\u3068\u7b4b\u8089\u91cf\uff08Journal of Applied Physiology\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9-2. ACTN3\u907a\u4f1d\u5b50\u3068\u7b4b\u8089\u306e\u8cea<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ACTN3\uff08\u03b1-\u30a2\u30af\u30c1\u30cb\u30f33\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>ACTN3\u306f\u901f\u7b4b\u7e4a\u7dad\uff08\u77ac\u767a\u529b\u3092\u767a\u63ee\u3059\u308b\u7b4b\u8089\uff09\u306e\u767a\u9054\u306b\u95a2\u4e0e\u3057\u3001\u907a\u4f1d\u7684\u591a\u578b\u306b\u3088\u3063\u3066\u7b4b\u8089\u306e\u8cea\u304c\u7570\u306a\u308b\u3002<\/li>\n\n\n\n<li><strong>ACTN3\u306eXX\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u7b4b\u529b\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u304f\u3001\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u30bf\u30f3\u30d1\u30af\u8cea\u6442\u53d6\uff08\u30db\u30a8\u30a4\u30d7\u30ed\u30c6\u30a4\u30f3\u3001\u5927\u8c46\u30d7\u30ed\u30c6\u30a4\u30f3\uff09\u304c\u7b4b\u8089\u7dad\u6301\u306b\u52b9\u679c\u7684\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/link.springer.com\/journal\/421\">ACTN3\u3068\u7b4b\u8089\u306e\u8001\u5316\uff08European Journal of Applied Physiology\uff09<\/a><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>10. \u907a\u4f1d\u5b50\u3068\u7761\u7720\u306e\u8cea\uff1a\u8001\u5316\u3068\u7761\u7720\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u7761\u7720\u306e\u8cea\u306f\u8001\u5316\u306e\u9032\u884c\u901f\u5ea6\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u6df1\u3044\u7761\u7720\u4e2d\u306b\u6210\u9577\u30db\u30eb\u30e2\u30f3\u304c\u5206\u6ccc\u3055\u308c\u3001\u7d30\u80de\u306e\u4fee\u5fa9\u304c\u884c\u308f\u308c\u308b\u305f\u3081\u3001\u8cea\u306e\u9ad8\u3044\u7761\u7720\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10-1. CLOCK\u907a\u4f1d\u5b50\u3068\u6982\u65e5\u30ea\u30ba\u30e0<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CLOCK\uff08\u4f53\u5185\u6642\u8a08\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>CLOCK\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u6982\u65e5\u30ea\u30ba\u30e0\u304c\u4e71\u308c\u3001\u7761\u7720\u306e\u8cea\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u591c\u578b\u306e\u907a\u4f1d\u5b50\u578b\uff08CC\u578b\uff09\u306f\u3001\u671d\u306e\u5149\u3092\u6d74\u3073\u308b\u3053\u3068\u3067\u30ea\u30ba\u30e0\u3092\u6574\u3048\u3084\u3059\u3044\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u30e1\u30e9\u30c8\u30cb\u30f3\u5206\u6ccc\u3092\u4fc3\u9032\u3059\u308b\u305f\u3081\u306b\u3001\u591c\u9593\u306e\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\u3092\u907f\u3051\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1aCLOCK\u907a\u4f1d\u5b50\u3068\u7761\u7720\uff08Sleep Journal\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10-2. MTNR1B\u907a\u4f1d\u5b50\u3068\u30e1\u30e9\u30c8\u30cb\u30f3\u53d7\u5bb9\u4f53<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MTNR1B\uff08\u30e1\u30e9\u30c8\u30cb\u30f3\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>MTNR1B\u306e\u7279\u5b9a\u306e\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u30e1\u30e9\u30c8\u30cb\u30f3\u306e\u611f\u53d7\u6027\u304c\u4f4e\u304f\u3001\u7761\u7720\u306e\u8cea\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u591c\u306b\u30ab\u30d5\u30a7\u30a4\u30f3\u3092\u907f\u3051\u3001\u30e1\u30e9\u30c8\u30cb\u30f3\u3092\u591a\u304f\u542b\u3080\u98df\u54c1\uff08\u30c1\u30a7\u30ea\u30fc\u3001\u30ca\u30c3\u30c4\uff09\u3092\u6442\u53d6\u3059\u308b\u3068\u7761\u7720\u6539\u5584\u306b\u5f79\u7acb\u3064\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/neuro\/\">MTNR1B\u3068\u7761\u7720\uff08Nature Neuroscience\uff09<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>11. \u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u5c55\u3068\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u533b\u7642\u306e\u672a\u6765<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"574\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/29974086_m-1024x574.jpg\" alt=\"\u30b9\u30ad\u30f3\u30b1\u30a2\u30fb\u5316\u7ca7\u6c34\u30fb\u4fdd\u6e7f\u306e\u30a4\u30e1\u30fc\u30b8\" class=\"wp-image-9636\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29974086_m-1024x574.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29974086_m-300x168.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29974086_m-768x430.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29974086_m-1536x861.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29974086_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8fd1\u5e74\u3001\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u8001\u5316\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>11-1. \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306b\u3088\u308b\u8001\u5316\u6291\u5236<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CRISPR\u6280\u8853\u3092\u6d3b\u7528\u3057\u305f\u8001\u5316\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u8abf\u6574<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>SIRT1\u3084TERT\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u306e\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u8a66\u307f\u304c\u9032\u884c\u4e2d\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u502b\u7406\u7684\u306a\u8ab2\u984c\u304c\u6b8b\u308b\u3082\u306e\u306e\u3001\u5c06\u6765\u7684\u306b\u306f\u500b\u5225\u5316\u6cbb\u7642\u306e\u4e00\u74b0\u3068\u3057\u3066\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1aCRISPR\u3068\u8001\u5316\u7814\u7a76\uff08Trends in Genetics\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>11-2. AI\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u533b\u7642<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AI\u304c\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3068\u5065\u5eb7\u60c5\u5831\u3092\u89e3\u6790\u3057\u3001\u500b\u5225\u6700\u9069\u5316\u3055\u308c\u305f\u8001\u5316\u9632\u6b62\u6226\u7565\u3092\u63d0\u6848<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u98df\u4e8b\u30fb\u904b\u52d5\u30fb\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6700\u9069\u306a\u7d44\u307f\u5408\u308f\u305b\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u8abf\u6574\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u30a6\u30a7\u30a2\u30e9\u30d6\u30eb\u30c7\u30d0\u30a4\u30b9\u3068\u9023\u643a\u3057\u3001\u5065\u5eb7\u72b6\u614b\u3092\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/npjdigitalmed\">AI\u3068\u500b\u5225\u5316\u533b\u7642\uff08npj Digital Medicine\uff09<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>12. \u907a\u4f1d\u5b50\u3068\u76ae\u819a\u306e\u8001\u5316\uff1a\u30b7\u30ef\u3084\u30b7\u30df\u3092\u9632\u3050\u5206\u5b50\u30ec\u30d9\u30eb\u306e\u6226\u7565<\/strong><\/h2>\n\n\n\n<p>\u76ae\u819a\u306e\u8001\u5316\u306f\u3001\u7d2b\u5916\u7dda\u3084\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3001\u30db\u30eb\u30e2\u30f3\u306e\u5909\u5316\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u76ae\u819a\u306e\u30cf\u30ea\u3084\u6c34\u5206\u4fdd\u6301\u80fd\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12-1. COL1A1\u907a\u4f1d\u5b50\u3068\u30b3\u30e9\u30fc\u30b2\u30f3\u5408\u6210<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>COL1A1\uff08\u30b3\u30e9\u30fc\u30b2\u30f3I\u578b\u03b11\u9396\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>COL1A1\u306f\u76ae\u819a\u306e\u5f3e\u529b\u3092\u7dad\u6301\u3059\u308b\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u5408\u6210\u306b\u95a2\u4e0e\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>COL1A1\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u591a\u578b\uff08Sp1\u5909\u7570\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u751f\u6210\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u304f\u3001\u30b7\u30ef\u304c\u3067\u304d\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308b\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u30d3\u30bf\u30df\u30f3C\uff08\u67d1\u6a58\u985e\u3001\u30d1\u30d7\u30ea\u30ab\uff09\u304c\u30b3\u30e9\u30fc\u30b2\u30f3\u5408\u6210\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.jdsjournal.com\/\">COL1A1\u3068\u76ae\u819a\u8001\u5316\uff08Journal of Dermatological Science\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12-2. MMP1\u907a\u4f1d\u5b50\u3068\u76ae\u819a\u306e\u5206\u89e3<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MMP1\uff08\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc1\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>MMP1\u306f\u76ae\u819a\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u3068\u30b7\u30ef\u304c\u3067\u304d\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u7d2b\u5916\u7dda\u306b\u3088\u3063\u3066MMP1\u306e\u767a\u73fe\u304c\u4fc3\u9032\u3055\u308c\u308b\u305f\u3081\u3001\u65e5\u713c\u3051\u6b62\u3081\uff08SPF30\u4ee5\u4e0a\uff09\u306e\u4f7f\u7528\u304c\u91cd\u8981\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/onlinelibrary.wiley.com\/journal\/16000625\">MMP1\u3068\u7d2b\u5916\u7dda\u8001\u5316\uff08Experimental Dermatology\uff09<\/a><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>13. \u907a\u4f1d\u5b50\u3068\u9aa8\u306e\u8001\u5316\uff1a\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u30ea\u30b9\u30af\u3092\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u7406\u89e3\u3059\u308b<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/26816665_s.jpg\" alt=\"DNA\" class=\"wp-image-1217\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/26816665_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/26816665_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure>\n\n\n\n<p>\u52a0\u9f62\u306b\u4f34\u3044\u3001\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u4e0b\u3057\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002\u9aa8\u306e\u8001\u5316\u3092\u9632\u3050\u305f\u3081\u306b\u306f\u3001\u9aa8\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u3092\u8003\u616e\u3057\u305f\u5bfe\u7b56\u304c\u6709\u52b9\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>13-1. VDR\u907a\u4f1d\u5b50\u3068\u30ab\u30eb\u30b7\u30a6\u30e0\u5438\u53ce<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>VDR\uff08\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>VDR\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u591a\u578b\uff08TaqI, FokI\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u6d3b\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u5438\u53ce\u52b9\u7387\u304c\u4e0b\u304c\u308b\u3002<\/li>\n\n\n\n<li><strong>\u65e5\u5149\u6d74\u3084\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\uff081000 IU\/\u65e5\uff09\u304c\u9aa8\u5bc6\u5ea6\u7dad\u6301\u306b\u5f79\u7acb\u3064\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a>VDR\u907a\u4f1d\u5b50\u3068\u9aa8\u5bc6\u5ea6\uff08Bone Journal\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>13-2. LRP5\u907a\u4f1d\u5b50\u3068\u9aa8\u5f62\u6210<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>LRP5\uff08\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u53d7\u5bb9\u4f53\u95a2\u9023\u30bf\u30f3\u30d1\u30af5\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>LRP5\u306f\u9aa8\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u7279\u5b9a\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u9aa8\u6298\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3002<\/li>\n\n\n\n<li><strong>\u30a6\u30a7\u30a4\u30c8\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3084\u9ad8\u5f37\u5ea6\u904b\u52d5\u304c\u9aa8\u5bc6\u5ea6\u3092\u7dad\u6301\u3059\u308b\u306e\u306b\u6709\u52b9\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/articles\/ng\">LRP5\u3068\u9aa8\u4ee3\u8b1d\uff08Nature Genetics\uff09<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>14. \u907a\u4f1d\u5b50\u3068\u8840\u7ba1\u306e\u8001\u5316\uff1a\u52d5\u8108\u786c\u5316\u3068\u8840\u6d41\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u8840\u7ba1\u306e\u67d4\u8edf\u6027\u304c\u5931\u308f\u308c\u308b\u3068\u3001\u52d5\u8108\u786c\u5316\u3084\u9ad8\u8840\u5727\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u3001\u8001\u5316\u304c\u52a0\u901f\u3057\u307e\u3059\u3002\u8840\u7ba1\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u8840\u7ba1\u6a5f\u80fd\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>14-1. eNOS\u907a\u4f1d\u5b50\u3068\u8840\u7ba1\u62e1\u5f35<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>eNOS\uff08\u5185\u76ae\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>eNOS\u306f\u8840\u7ba1\u3092\u62e1\u5f35\u3057\u3001\u8840\u6d41\u3092\u6539\u5584\u3059\u308b\u4e00\u9178\u5316\u7a92\u7d20\uff08NO\uff09\u3092\u751f\u6210\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>eNOS\u306e\u6a5f\u80fd\u304c\u4f4e\u3044\u907a\u4f1d\u578b\uff08T786C\u5909\u7570\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u9ad8\u8840\u5727\u3084\u52d5\u8108\u786c\u5316\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u30ca\u30c3\u30c4\u985e\u3084\u30c0\u30fc\u30af\u30c1\u30e7\u30b3\u30ec\u30fc\u30c8\uff08\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\uff09\u304cNO\u306e\u7523\u751f\u3092\u4fc3\u9032\u3059\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a>eNOS\u3068\u8840\u7ba1\u8001\u5316\uff08Circulation Research\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>14-2. ACE\u907a\u4f1d\u5b50\u3068\u8840\u5727\u8abf\u7bc0<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ACE\uff08\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d20\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>ACE\u306f\u8840\u5727\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u578b\uff08DD\u578b\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u9ad8\u8840\u5727\u3084\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3002<\/li>\n\n\n\n<li><strong>\u6e1b\u5869\u98df\uff081\u65e55g\u4ee5\u4e0b\uff09\u3084\u30ab\u30ea\u30a6\u30e0\u6442\u53d6\uff08\u30d0\u30ca\u30ca\u3001\u307b\u3046\u308c\u3093\u8349\uff09\u304c\u8840\u5727\u7ba1\u7406\u306b\u6709\u52b9\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a>ACE\u907a\u4f1d\u5b50\u3068\u9ad8\u8840\u5727\uff08Journal of Hypertension\uff09<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>15. \u907a\u4f1d\u5b50\u3068\u8178\u5185\u74b0\u5883\u306e\u8001\u5316\uff1a\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u3068\u5065\u5eb7\u5bff\u547d\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"681\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/30727945_m-1024x681.jpg\" alt=\"\u30b9\u30ea\u30e0\u3067\u5065\u5eb7\u7684\u306a\u5973\u6027\u306e\u304a\u8179\u5468\u308a\" class=\"wp-image-9673\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30727945_m-1024x681.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30727945_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30727945_m-768x511.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30727945_m-1536x1022.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30727945_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8178\u5185\u7d30\u83cc\u306f\u514d\u75ab\u6a5f\u80fd\u3084\u4ee3\u8b1d\u3001\u708e\u75c7\u53cd\u5fdc\u306b\u95a2\u4e0e\u3057\u3001\u8001\u5316\u306e\u9032\u884c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u907a\u4f1d\u7684\u8981\u56e0\u304c\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u69cb\u6210\u3092\u6c7a\u5b9a\u3059\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>15-1. FUT2\u907a\u4f1d\u5b50\u3068\u8178\u5185\u7d30\u83cc<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FUT2\uff08\u30d5\u30b3\u30fc\u30b9\u8ee2\u79fb\u9175\u7d202\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>FUT2\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u8178\u5185\u306e\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\u304c\u5c11\u306a\u304f\u3001\u8178\u5185\u74b0\u5883\u304c\u4e71\u308c\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u767a\u9175\u98df\u54c1\uff08\u30e8\u30fc\u30b0\u30eb\u30c8\u3001\u30ad\u30e0\u30c1\uff09\u3084\u98df\u7269\u7e4a\u7dad\uff08\u30aa\u30fc\u30c8\u30df\u30fc\u30eb\uff09\u3092\u6442\u53d6\u3059\u308b\u3068\u3001\u8178\u5185\u74b0\u5883\u3092\u6539\u5584\u3067\u304d\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a>FUT2\u3068\u8178\u5185\u30d5\u30ed\u30fc\u30e9\uff08Gut Microbes Journal\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>15-2. TLR4\u907a\u4f1d\u5b50\u3068\u8178\u306e\u708e\u75c7<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>TLR4\uff08\u30c8\u30fc\u30eb\u69d8\u53d7\u5bb9\u4f534\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>TLR4\u306f\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u4e00\u90e8\u3067\u3042\u308a\u3001\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3002<\/li>\n\n\n\n<li><strong>TLR4\u306e\u7279\u5b9a\u306e\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u8178\u306e\u708e\u75c7\u304c\u8d77\u3053\u308a\u3084\u3059\u3044\u305f\u3081\u3001\u6297\u708e\u75c7\u4f5c\u7528\u306e\u3042\u308b\u98df\u4e8b\uff08\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3001\u7dd1\u8336\uff09\u304c\u63a8\u5968\u3055\u308c\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/articles\/ni\">TLR4\u3068\u8178\u306e\u5065\u5eb7\uff08Nature Immunology\uff09<\/a><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>16. \u907a\u4f1d\u5b50\u3068\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306e\u95a2\u4fc2\uff1a\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u30db\u30eb\u30e2\u30f3\u5236\u5fa1<\/strong><\/h2>\n\n\n\n<p>\u30db\u30eb\u30e2\u30f3\u306f\u8001\u5316\u306e\u901f\u5ea6\u3092\u5927\u304d\u304f\u5de6\u53f3\u3057\u307e\u3059\u3002\u6210\u9577\u30db\u30eb\u30e2\u30f3\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306a\u3069\u306e\u30db\u30eb\u30e2\u30f3\u306e\u5206\u6ccc\u91cf\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u52a0\u9f62\u306b\u3088\u3063\u3066\u5909\u5316\u3057\u3001\u8001\u5316\u306e\u9032\u884c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>16-1. IGF-1\u907a\u4f1d\u5b50\u3068\u6210\u9577\u30db\u30eb\u30e2\u30f3\u306e\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IGF-1\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u6210\u9577\u56e0\u5b501\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>IGF-1\u306f\u6210\u9577\u30db\u30eb\u30e2\u30f3\u3068\u9023\u643a\u3057\u3066\u7d30\u80de\u306e\u4fee\u5fa9\u3068\u518d\u751f\u3092\u4fc3\u9032\u3059\u308b\u304c\u3001\u904e\u5270\u306aIGF-1\u306f\u8001\u5316\u3092\u52a0\u901f\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>IGF-1\u306e\u907a\u4f1d\u7684\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u9069\u5207\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u6442\u53d6\u91cf\u3092\u8abf\u6574\u3059\u308b\u3053\u3068\u3067\u3001\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u3092\u6700\u9069\u5316\u3067\u304d\u308b\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u3084\u9593\u6b20\u7684\u30d5\u30a1\u30b9\u30c6\u30a3\u30f3\u30b0\u304cIGF-1\u306e\u904e\u5270\u306a\u5206\u6ccc\u3092\u6291\u3048\u3001\u5065\u5eb7\u5bff\u547d\u3092\u5ef6\u3070\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/nataging\/\">IGF-1\u3068\u8001\u5316\u306e\u95a2\u4fc2\uff08Nature Aging\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>16-2. CYP19A1\u907a\u4f1d\u5b50\u3068\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u4ee3\u8b1d<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CYP19A1\uff08\u30a2\u30ed\u30de\u30bf\u30fc\u30bc\uff09\u907a\u4f1d\u5b50<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u5408\u6210\u306b\u95a2\u4e0e\u3057\u3001\u7279\u5b9a\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u30ec\u30d9\u30eb\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u9aa8\u5bc6\u5ea6\u6e1b\u5c11\u3001\u76ae\u819a\u306e\u5f3e\u529b\u4f4e\u4e0b\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u304c\u4e0a\u6607\u3059\u308b\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\uff08\u8c46\u8150\u3001\u7d0d\u8c46\uff09\u3092\u6442\u53d6\u3059\u308b\u3068\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u50cd\u304d\u3092\u88dc\u3046\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a>\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3068\u8001\u5316\uff08Journal of Endocrinology &amp; Metabolism\uff09<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>17. \u907a\u4f1d\u5b50\u3068\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\uff1a\u52b9\u679c\u7684\u306a\u6804\u990a\u6226\u7565<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"681\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/23202713_m-1024x681.jpg\" alt=\"\" class=\"wp-image-8043\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23202713_m-1024x681.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23202713_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23202713_m-768x511.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23202713_m-1536x1022.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23202713_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8fd1\u5e74\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u3066\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u500b\u3005\u306e\u907a\u4f1d\u5b50\u578b\u306b\u57fa\u3065\u3044\u305f\u6804\u990a\u88dc\u7d66\u304c\u3001\u8001\u5316\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u9375\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>17-1. NAD+\u3068SIRT1\u306e\u6d3b\u6027\u5316<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>NAD+\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30a2\u30c7\u30cb\u30f3\u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff09<\/strong>\n<ul class=\"wp-block-list\">\n<li>NAD+\u306f\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3068DNA\u4fee\u5fa9\u306b\u95a2\u4e0e\u3057\u3001\u52a0\u9f62\u3068\u3068\u3082\u306b\u6e1b\u5c11\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>NMN\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30e2\u30ce\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff09\u3084NR\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30ea\u30dc\u30b7\u30c9\uff09\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u3001SIRT1\u3092\u6d3b\u6027\u5316\u3057\u3001\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a>NAD+\u3068\u8001\u5316\uff08Cell Metabolism\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>17-2. \u30e1\u30c8\u30db\u30eb\u30df\u30f3\u3068\u907a\u4f1d\u5b50\u8001\u5316<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30e1\u30c8\u30db\u30eb\u30df\u30f3\uff08\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\uff09<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306fAMPK\uff08AMP\u6d3b\u6027\u5316\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\uff09\u3092\u6d3b\u6027\u5316\u3057\u3001\u8001\u5316\u95a2\u9023\u306e\u75be\u60a3\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u578b\uff08SIRT1\u3084FOXO3\u306e\u5909\u7570\uff09\u3092\u6301\u3064\u4eba\u306b\u3068\u3063\u3066\u3001\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u304c\u5bff\u547d\u5ef6\u9577\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/nrendo\/\">\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u3068\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\uff08Nature Reviews Endocrinology\uff09<\/a><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>18. \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3068\u8001\u5316\u7814\u7a76\u306e\u672a\u6765<\/strong><\/h2>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306e\u9032\u5316\u306b\u3088\u308a\u3001\u8001\u5316\u3092\u6291\u5236\u3059\u308b\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>18-1. CRISPR\u3092\u7528\u3044\u305f\u8001\u5316\u907a\u4f1d\u5b50\u306e\u6539\u5909<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CRISPR-Cas9\u6280\u8853\u306b\u3088\u308a\u3001\u8001\u5316\u95a2\u9023\u907a\u4f1d\u5b50\uff08SIRT1\u3001TERT\u3001FOXO3\uff09\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3057\u3001\u8001\u5316\u901f\u5ea6\u3092\u5236\u5fa1\u3059\u308b\u8a66\u307f\u304c\u9032\u884c\u4e2d\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u502b\u7406\u7684\u306a\u554f\u984c\u3092\u30af\u30ea\u30a2\u3059\u308b\u305f\u3081\u3001\u30d2\u30c8\u3078\u306e\u9069\u7528\u306b\u306f\u614e\u91cd\u306a\u691c\u8a0e\u304c\u5fc5\u8981\u3002<\/strong><\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a>CRISPR\u3068\u8001\u5316\u7814\u7a76\uff08Trends in Biotechnology\uff09<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>18-2. \u907a\u4f1d\u5b50\u6cbb\u7642\u3068\u5e79\u7d30\u80de\u518d\u751f\u533b\u7642<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>iPS\u7d30\u80de\u3092\u6d3b\u7528\u3057\u305f\u7d44\u7e54\u518d\u751f<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u52a0\u9f62\u306b\u3088\u308b\u7d44\u7e54\u306e\u640d\u50b7\u3092\u4fee\u5fa9\u3059\u308b\u305f\u3081\u306b\u3001iPS\u7d30\u80de\u3092\u5229\u7528\u3057\u305f\u518d\u751f\u533b\u7642\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u5fc3\u8840\u7ba1\u75be\u60a3\u3084\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u6cbb\u7642\u306b\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\ud83d\udd17 <strong>\u53c2\u8003\u6587\u732e<\/strong>\uff1a<a href=\"https:\/\/stemcellsjournals.onlinelibrary.wiley.com\/\">\u5e79\u7d30\u80de\u3068\u8001\u5316\uff08Stem Cells Translational Medicine\uff09<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u307e\u3068\u3081<\/strong><\/h2>\n\n\n\n<p>\u8001\u5316\u306e\u9032\u884c\u901f\u5ea6\u306f\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u5de6\u53f3\u3055\u308c\u307e\u3059\u3002SIRT1\u3001FOXO3\u3001TERT\u3001APOE\u306a\u3069\u306e\u907a\u4f1d\u5b50\u304c\u7d30\u80de\u306e\u4fee\u5fa9\u3001\u6297\u9178\u5316\u3001\u9632\u5fa1\u6a5f\u80fd\u306b\u95a2\u4e0e\u3057\u3001\u9069\u5207\u306a\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3084\u6804\u990a\u6226\u7565\u306b\u3088\u3063\u3066\u305d\u306e\u50cd\u304d\u3092\u6700\u5927\u5316\u3067\u304d\u307e\u3059\u3002\u3055\u3089\u306b\u3001CRISPR\u306b\u3088\u308b\u907a\u4f1d\u5b50\u7de8\u96c6\u3084NAD+\u88dc\u5145\u7642\u6cd5\u3001\u5e79\u7d30\u80de\u6cbb\u7642\u306a\u3069\u306e\u6700\u5148\u7aef\u6280\u8853\u304c\u3001\u8001\u5316\u306e\u5236\u5fa1\u306b\u65b0\u305f\u306a\u53ef\u80fd\u6027\u3092\u3082\u305f\u3089\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u767a\u5c55\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u305f\u6700\u9069\u306a\u8001\u5316\u9632\u6b62\u7b56\u304c\u5b9f\u73fe\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u306f\u3058\u3081\u306b 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