{"id":9986,"date":"2025-03-14T08:06:32","date_gmt":"2025-03-14T08:06:32","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=9986"},"modified":"2025-03-14T08:06:34","modified_gmt":"2025-03-14T08:06:34","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e7%b3%96%e8%b3%aa%e3%81%ae%e5%90%b8%e5%8f%8e%ef%bc%9a%e3%83%80%e3%82%a4%e3%82%a8%e3%83%83%e3%83%88%e3%81%ab%e5%bd%b9%e7%ab%8b%e3%81%a4%e6%96%b0%e6%83%85%e5%a0%b1","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e7%b3%96%e8%b3%aa%e3%81%ae%e5%90%b8%e5%8f%8e%ef%bc%9a%e3%83%80%e3%82%a4%e3%82%a8%e3%83%83%e3%83%88%e3%81%ab%e5%bd%b9%e7%ab%8b%e3%81%a4%e6%96%b0%e6%83%85%e5%a0%b1\/","title":{"rendered":"\u907a\u4f1d\u5b50\u3068\u7cd6\u8cea\u306e\u5438\u53ce\uff1a\u30c0\u30a4\u30a8\u30c3\u30c8\u306b\u5f79\u7acb\u3064\u65b0\u60c5\u5831"},"content":{"rendered":"\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u306f\u3058\u3081\u306b<\/strong><\/h2>\n\n\n\n<p>\u7cd6\u8cea\u306e\u5438\u53ce\u3084\u4ee3\u8b1d\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u3001\u540c\u3058\u98df\u4e8b\u3092\u3057\u3066\u3082\u8840\u7cd6\u5024\u306e\u4e0a\u304c\u308a\u65b9\u3084\u592a\u308a\u3084\u3059\u3055\u304c\u7570\u306a\u308b\u306e\u306f\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u3053\u306e\u9055\u3044\u306e\u4e00\u56e0\u3068\u3057\u3066\u300c\u907a\u4f1d\u5b50\u306e\u500b\u4eba\u5dee\u300d\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u7cd6\u8cea\u306e\u5438\u53ce\u80fd\u529b\u304c\u7570\u306a\u308a\u3001\u30c0\u30a4\u30a8\u30c3\u30c8\u3084\u5065\u5eb7\u7ba1\u7406\u306e\u52b9\u679c\u3082\u4eba\u305d\u308c\u305e\u308c\u9055\u3046\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u672c\u8a18\u4e8b\u3067\u306f\u3001\u7cd6\u8cea\u306e\u5438\u53ce\u3068\u4ee3\u8b1d\u306b\u95a2\u308f\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50\u3084\u3001\u305d\u308c\u3089\u306e\u591a\u578b\uff08\u500b\u4eba\u3054\u3068\u306e\u9055\u3044\uff09\u304c\u30c0\u30a4\u30a8\u30c3\u30c8\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7cd6\u8cea\u306e\u5438\u53ce\u3068\u4ee3\u8b1d\u3092\u6c7a\u5b9a\u3059\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"576\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/25991800_m-1024x576.jpg\" alt=\"\" class=\"wp-image-9296\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/25991800_m-1024x576.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/25991800_m-300x169.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/25991800_m-768x432.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/25991800_m-1536x864.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/25991800_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. AMY1\u907a\u4f1d\u5b50\uff08\u30a2\u30df\u30e9\u30fc\u30bc\u907a\u4f1d\u5b50\uff09<\/strong><\/h3>\n\n\n\n<p>AMY1\u907a\u4f1d\u5b50\u306f\u3001\u553e\u6db2\u4e2d\u306b\u542b\u307e\u308c\u308b\u30a2\u30df\u30e9\u30fc\u30bc\uff08\u30c7\u30f3\u30d7\u30f3\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\uff09\u306e\u7523\u751f\u3092\u8abf\u6574\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u30b3\u30d4\u30fc\u6570\u304c\u591a\u3044\u307b\u3069\u30a2\u30df\u30e9\u30fc\u30bc\u306e\u5206\u6ccc\u91cf\u304c\u5897\u3048\u3001\u7cd6\u8cea\u306e\u6d88\u5316\u304c\u901f\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>AMY1\u907a\u4f1d\u5b50\u306e\u30b3\u30d4\u30fc\u6570\u304c\u591a\u3044\u4eba\u306f\u3001\u30c7\u30f3\u30d7\u30f3\u306e\u5206\u89e3\u304c\u901f\u304f\u3001\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u304c\u7de9\u3084\u304b\u306b\u306a\u308b\u50be\u5411\u304c\u3042\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Cell Metabolism\uff09\u3002<\/li>\n\n\n\n<li>\u9006\u306b\u3001\u30b3\u30d4\u30fc\u6570\u304c\u5c11\u306a\u3044\u4eba\u306f\u7cd6\u8cea\u306e\u6d88\u5316\u304c\u9045\u308c\u3001\u80a5\u6e80\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30b3\u30d4\u30fc\u6570\u304c\u591a\u3044\u4eba<\/strong>\uff1a\u4f4e\u7cd6\u8cea\u30c0\u30a4\u30a8\u30c3\u30c8\u306f\u52b9\u679c\u304c\u8584\u304f\u3001\u3080\u3057\u308d\u7cd6\u8cea\u3092\u9069\u5ea6\u306b\u6442\u53d6\u3057\u305f\u65b9\u304c\u5065\u5eb7\u7684\u3002<\/li>\n\n\n\n<li><strong>\u30b3\u30d4\u30fc\u6570\u304c\u5c11\u306a\u3044\u4eba<\/strong>\uff1a\u7cd6\u8cea\u5236\u9650\u3092\u3059\u308b\u3068\u30c0\u30a4\u30a8\u30c3\u30c8\u52b9\u679c\u304c\u9ad8\u307e\u308a\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. SLC2A2\u907a\u4f1d\u5b50\uff08GLUT2\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u907a\u4f1d\u5b50\uff09<\/strong><\/h3>\n\n\n\n<p>SLC2A2\u907a\u4f1d\u5b50\u306f\u3001\u5c0f\u8178\u3067\u30b0\u30eb\u30b3\u30fc\u30b9\u3092\u5438\u53ce\u3059\u308b\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\uff08GLUT2\uff09\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u7cd6\u8cea\u306e\u5438\u53ce\u901f\u5ea6\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>SLC2A2\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u591a\u578b\uff08rs5400\u5909\u7570\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u7cd6\u8cea\u3092\u7d20\u65e9\u304f\u5438\u53ce\u3057\u3084\u3059\u304f\u3001\u8840\u7cd6\u5024\u304c\u6025\u4e0a\u6607\u3057\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/ng.2939?utm_source=chatgpt.com\">Nature Genetics<\/a>\uff09\u3002<\/li>\n\n\n\n<li>\u3053\u306e\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\uff08\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\uff09\u304c\u9ad8\u307e\u308a\u3084\u3059\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7cd6\u8cea\u3092\u5438\u53ce\u3057\u3084\u3059\u3044\u4eba<\/strong>\uff1a\u8840\u7cd6\u5024\u306e\u6025\u4e0a\u6607\u3092\u6291\u3048\u308b\u305f\u3081\u3001\u4f4eGI\u98df\u54c1\uff08\u7384\u7c73\u3001\u5168\u7c92\u7c89\u30d1\u30f3\u306a\u3069\uff09\u3092\u9078\u3076\u306e\u304c\u6709\u52b9\u3002<\/li>\n\n\n\n<li><strong>\u7cd6\u8cea\u3092\u5438\u53ce\u3057\u306b\u304f\u3044\u4eba<\/strong>\uff1a\u30a8\u30cd\u30eb\u30ae\u30fc\u4e0d\u8db3\u306b\u306a\u308a\u3084\u3059\u3044\u305f\u3081\u3001\u9069\u5ea6\u306a\u7cd6\u8cea\u6442\u53d6\u304c\u63a8\u5968\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. TCF7L2\u907a\u4f1d\u5b50\uff08\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u907a\u4f1d\u5b50\uff09<\/strong><\/h3>\n\n\n\n<p>TCF7L2\u907a\u4f1d\u5b50\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306b\u95a2\u4e0e\u3057\u3001\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3084\u7cd6\u8cea\u4ee3\u8b1d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306b\u7279\u5b9a\u306e\u591a\u578b\uff08rs7903146\u5909\u7570\uff09\u304c\u3042\u308b\u3068\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u5206\u6ccc\u304c\u4f4e\u4e0b\u3057\u3001\u7cd6\u8cea\u306e\u51e6\u7406\u304c\u9045\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>rs7903146\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u901a\u5e38\u3088\u308a\u3082\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Diabetes Journal\uff09\u3002<\/li>\n\n\n\n<li>\u3053\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u7cd6\u8cea\u5236\u9650\u3088\u308a\u3082\u300c\u9069\u5207\u306a\u98df\u4e8b\u30d0\u30e9\u30f3\u30b9\u300d\u3068\u300c\u904b\u52d5\u300d\u306e\u65b9\u304c\u52b9\u679c\u7684\u306a\u4f53\u91cd\u7ba1\u7406\u6cd5\u3067\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u8840\u7cd6\u5024\u306e\u7ba1\u7406\u3092\u610f\u8b58\u3057\u306a\u304c\u3089\u3001\u98df\u7269\u7e4a\u7dad\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u591a\u304f\u542b\u3080\u98df\u4e8b\u3092\u5fc3\u304c\u3051\u308b\u3002<\/li>\n\n\n\n<li><strong>\u5909\u7570\u304c\u306a\u3044\u4eba<\/strong>\uff1a\u901a\u5e38\u306e\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u3067\u5341\u5206\u306a\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7cd6\u8cea\u306e\u4ee3\u8b1d\u3068\u4f53\u5185\u30ea\u30ba\u30e0\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/3881826_m-1024x683.jpg\" alt=\"\u6df1\u547c\u5438\u3059\u308b\u7537\u6027\" class=\"wp-image-9747\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3881826_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3881826_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3881826_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3881826_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3881826_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. CLOCK\u907a\u4f1d\u5b50\u3068\u98df\u4e8b\u306e\u30bf\u30a4\u30df\u30f3\u30b0<\/strong><\/h3>\n\n\n\n<p>CLOCK\u907a\u4f1d\u5b50\u306f\u4f53\u5185\u306e\u6982\u65e5\u30ea\u30ba\u30e0\uff08\u30b5\u30fc\u30ab\u30c7\u30a3\u30a2\u30f3\u30ea\u30ba\u30e0\uff09\u3092\u8abf\u6574\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u7cd6\u8cea\u306e\u4ee3\u8b1d\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>CLOCK\u907a\u4f1d\u5b50\u306e\u5909\u7570\uff08rs1801260\uff09\u304c\u3042\u308b\u3068\u3001\u591c\u9593\u306b\u7cd6\u8cea\u3092\u6442\u53d6\u3059\u308b\u3068\u8102\u80aa\u3068\u3057\u3066\u84c4\u7a4d\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08The American Journal of Clinical Nutrition\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u5915\u98df\u3084\u591c\u98df\u3067\u7cd6\u8cea\u3092\u63a7\u3048\u308b\u3068\u52b9\u679c\u7684\u306a\u4f53\u91cd\u7ba1\u7406\u304c\u53ef\u80fd\u3002<\/li>\n\n\n\n<li><strong>\u5909\u7570\u304c\u306a\u3044\u4eba<\/strong>\uff1a\u7cd6\u8cea\u306e\u6442\u53d6\u30bf\u30a4\u30df\u30f3\u30b0\u306e\u5f71\u97ff\u306f\u6bd4\u8f03\u7684\u5c11\u306a\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u30c0\u30a4\u30a8\u30c3\u30c8\u6226\u7565<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u6d3b\u7528\u65b9\u6cd5<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u53d7\u3051\u308b<\/strong>\uff1aAMY1\u3001SLC2A2\u3001TCF7L2\u3001CLOCK\u907a\u4f1d\u5b50\u306a\u3069\u3092\u691c\u67fb\u3059\u308b\u3053\u3068\u3067\u3001\u81ea\u5206\u306b\u5408\u3063\u305f\u98df\u4e8b\u6cd5\u304c\u5206\u304b\u308b\u3002<\/li>\n\n\n\n<li><strong>\u500b\u5225\u6700\u9069\u5316\u3055\u308c\u305f\u98df\u4e8b\u8a08\u753b\u3092\u7acb\u3066\u308b<\/strong>\uff1a\u907a\u4f1d\u5b50\u306e\u7279\u5fb4\u306b\u5fdc\u3058\u3066\u3001\u7cd6\u8cea\u6442\u53d6\u91cf\u3084\u98df\u4e8b\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3092\u8abf\u6574\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30c0\u30a4\u30a8\u30c3\u30c8\u306e\u672a\u6765<\/strong><\/h3>\n\n\n\n<p>\u8fd1\u5e74\u3001\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u6804\u990a\u5b66\u304c\u767a\u5c55\u3057\u3066\u304a\u308a\u3001\u4e00\u4eba\u3072\u3068\u308a\u306b\u6700\u9069\u306a\u98df\u4e8b\u6cd5\u304c\u63d0\u6848\u3067\u304d\u308b\u6642\u4ee3\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u7cd6\u8cea\u306e\u5438\u53ce\u3084\u4ee3\u8b1d\u306b\u95a2\u3059\u308b\u907a\u4f1d\u7684\u306a\u9055\u3044\u3092\u7406\u89e3\u3057\u3001\u305d\u308c\u306b\u57fa\u3065\u3044\u305f\u98df\u4e8b\u6226\u7565\u3092\u63a1\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u30c0\u30a4\u30a8\u30c3\u30c8\u304c\u5b9f\u73fe\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-1024x683.jpg\" alt=\"\u30bf\u30d6\u30ec\u30c3\u30c8\u3092\u64cd\u4f5c\u3059\u308b\u7537\u6027\u533b\u5e2b\" class=\"wp-image-9770\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. PPARG\u907a\u4f1d\u5b50\u3068\u7cd6\u8cea\u4ee3\u8b1d<\/strong><\/h3>\n\n\n\n<p>PPARG\uff08\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u30ac\u30f3\u30de\uff09\u907a\u4f1d\u5b50\u306f\u3001\u8102\u8cea\u3084\u7cd6\u8cea\u306e\u4ee3\u8b1d\u3092\u8abf\u6574\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u591a\u578b\uff08rs1801282\u5909\u7570\uff09\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3084\u8102\u80aa\u7d30\u80de\u306e\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>rs1801282\u5909\u7570\uff08Pro12Ala\u5909\u7570\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u304c\u9ad8\u307e\u308a\u3001\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u4e0b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08Diabetes Journal\uff09\u3002<\/li>\n\n\n\n<li>\u9006\u306b\u3001Pro12\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u9ad8\u307e\u308a\u3084\u3059\u304f\u3001\u7cd6\u8cea\u4ee3\u8b1d\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Pro12Ala\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u9069\u5ea6\u306a\u7cd6\u8cea\u6442\u53d6\u304c\u4ee3\u8b1d\u3092\u52a9\u3051\u3001\u904b\u52d5\u3068\u306e\u4f75\u7528\u3067\u30c0\u30a4\u30a8\u30c3\u30c8\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u308b\u3002<\/li>\n\n\n\n<li><strong>Pro12\u578b\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u4f4e\u7cd6\u8cea\u30c0\u30a4\u30a8\u30c3\u30c8\u304c\u6709\u52b9\u3067\u3042\u308a\u3001\u8102\u8cea\u4ee3\u8b1d\u3092\u91cd\u8996\u3057\u305f\u98df\u4e8b\u304c\u63a8\u5968\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. IRS1\u907a\u4f1d\u5b50\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u30b7\u30b0\u30ca\u30eb<\/strong><\/h3>\n\n\n\n<p>IRS1\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u53d7\u5bb9\u4f53\u57fa\u8cea1\uff09\u907a\u4f1d\u5b50\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u30b7\u30b0\u30ca\u30eb\u306e\u4f1d\u9054\u306b\u95a2\u4e0e\u3057\u3001\u8840\u7cd6\u5024\u306e\u8abf\u6574\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u7279\u5b9a\u306e\u591a\u578b\uff08rs2943641\u5909\u7570\uff09\u3092\u6301\u3064\u3068\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u9ad8\u307e\u308a\u3084\u3059\u304f\u306a\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>rs2943641\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u901a\u5e38\u3088\u308a\u3082\u7cd6\u8cea\u6442\u53d6\u5f8c\u306e\u8840\u7cd6\u5024\u4e0a\u6607\u304c\u9855\u8457\u3067\u3042\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08The American Journal of Clinical Nutrition\uff09\u3002<\/li>\n\n\n\n<li>\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u9ad8\u3044\u3068\u3001\u8102\u80aa\u306e\u84c4\u7a4d\u304c\u9032\u307f\u3084\u3059\u304f\u306a\u308b\u305f\u3081\u3001\u7cd6\u8cea\u7ba1\u7406\u304c\u91cd\u8981\u3068\u306a\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u7cd6\u8cea\u306e\u6442\u53d6\u91cf\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3057\u3001\u9069\u5207\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u8102\u8cea\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u53d6\u308b\u3053\u3068\u3067\u8840\u7cd6\u7ba1\u7406\u3092\u6700\u9069\u5316\u3002<\/li>\n\n\n\n<li><strong>\u5909\u7570\u304c\u306a\u3044\u4eba<\/strong>\uff1a\u7cd6\u8cea\u3092\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u3057\u3066\u5229\u7528\u3057\u3084\u3059\u304f\u3001\u30d0\u30e9\u30f3\u30b9\u306e\u826f\u3044\u98df\u4e8b\u3092\u5fc3\u304c\u3051\u308b\u3053\u3068\u3067\u4f53\u91cd\u7ba1\u7406\u304c\u3057\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u8178\u5185\u74b0\u5883\u3068\u907a\u4f1d\u5b50\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"681\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/30727945_m-1024x681.jpg\" alt=\"\u30b9\u30ea\u30e0\u3067\u5065\u5eb7\u7684\u306a\u5973\u6027\u306e\u304a\u8179\u5468\u308a\" class=\"wp-image-9673\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30727945_m-1024x681.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30727945_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30727945_m-768x511.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30727945_m-1536x1022.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30727945_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u8178\u5185\u7d30\u83cc\u3068\u7cd6\u8cea\u5438\u53ce\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u8178\u5185\u7d30\u83cc\u306f\u3001\u7cd6\u8cea\u306e\u5438\u53ce\u3084\u4ee3\u8b1d\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u907a\u4f1d\u7684\u8981\u56e0\u306b\u52a0\u3048\u3066\u3001\u8178\u5185\u74b0\u5883\u306e\u9055\u3044\u304c\u7cd6\u8cea\u306e\u5229\u7528\u52b9\u7387\u3092\u5909\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7279\u5b9a\u306e\u8178\u5185\u7d30\u83cc\uff08Firmicutes\u3068Bacteroidetes\u306e\u6bd4\u7387\uff09\u304c\u7cd6\u8cea\u306e\u5438\u53ce\u52b9\u7387\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Cell\uff09\u3002<\/li>\n\n\n\n<li>Firmicutes\u306e\u5272\u5408\u304c\u9ad8\u3044\u4eba\u306f\u3001\u7cd6\u8cea\u3084\u8102\u8cea\u3092\u3088\u308a\u52b9\u7387\u7684\u306b\u5438\u53ce\u3057\u3084\u3059\u304f\u3001\u4f53\u8102\u80aa\u306e\u84c4\u7a4d\u304c\u9032\u307f\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Firmicutes\u304c\u591a\u3044\u4eba<\/strong>\uff1a\u98df\u7269\u7e4a\u7dad\u3092\u5897\u3084\u3057\u3001\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u7cd6\u8cea\u5438\u53ce\u3092\u8abf\u6574\u3002<\/li>\n\n\n\n<li><strong>Bacteroidetes\u304c\u591a\u3044\u4eba<\/strong>\uff1a\u7cd6\u8cea\u3092\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u3057\u3066\u9069\u5207\u306b\u4ee3\u8b1d\u3067\u304d\u308b\u305f\u3081\u3001\u7279\u5225\u306a\u5236\u9650\u306f\u4e0d\u8981\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. FGF21\u907a\u4f1d\u5b50\u3068\u7cd6\u8cea\u55dc\u597d<\/strong><\/h3>\n\n\n\n<p>FGF21\uff08\u7dda\u7dad\u82bd\u7d30\u80de\u6210\u9577\u56e0\u5b5021\uff09\u907a\u4f1d\u5b50\u306f\u3001\u7cd6\u8cea\u3078\u306e\u55dc\u597d\u3084\u4ee3\u8b1d\u3092\u8abf\u6574\u3059\u308b\u5f79\u5272\u3092\u6301\u3061\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u591a\u578b\uff08rs838133\u5909\u7570\uff09\u304c\u3042\u308b\u3068\u3001\u7cd6\u8cea\u3078\u306e\u6b32\u6c42\u304c\u5f37\u304f\u306a\u308b\u50be\u5411\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>rs838133\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u7518\u3044\u3082\u306e\u3092\u597d\u3080\u50be\u5411\u304c\u5f37\u304f\u3001\u7cd6\u8cea\u6442\u53d6\u91cf\u304c\u591a\u304f\u306a\u308a\u3084\u3059\u3044\uff08Cell Metabolism\uff09\u3002<\/li>\n\n\n\n<li>\u3053\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u9069\u5ea6\u306a\u7cd6\u8cea\u5236\u9650\u304c\u4f53\u91cd\u7ba1\u7406\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u7cd6\u8cea\u6442\u53d6\u3092\u610f\u8b58\u3057\u3066\u5236\u9650\u3057\u3001\u4ee3\u66ff\u7518\u5473\u6599\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6d3b\u7528\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u5909\u7570\u304c\u306a\u3044\u4eba<\/strong>\uff1a\u7cd6\u8cea\u3078\u306e\u6b32\u6c42\u304c\u5c11\u306a\u3044\u305f\u3081\u3001\u81ea\u7136\u306b\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u98df\u4e8b\u304c\u3067\u304d\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u98df\u4e8b\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. BMAL1\u907a\u4f1d\u5b50\u3068\u591c\u9593\u306e\u7cd6\u8cea\u4ee3\u8b1d<\/strong><\/h3>\n\n\n\n<p>BMAL1\u907a\u4f1d\u5b50\u306f\u6982\u65e5\u30ea\u30ba\u30e0\u3092\u5236\u5fa1\u3057\u3001\u4ee3\u8b1d\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3092\u8abf\u6574\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\uff08rs2290036\u5909\u7570\uff09\u304c\u3042\u308b\u3068\u3001\u591c\u9593\u306b\u7cd6\u8cea\u3092\u6442\u53d6\u3059\u308b\u3068\u8102\u80aa\u3068\u3057\u3066\u84c4\u7a4d\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>BMAL1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u591c\u9593\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/ncomms14202?utm_source=chatgpt.com\">Nature Communications<\/a>\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u591c\u9593\u306e\u7cd6\u8cea\u6442\u53d6\u3092\u63a7\u3048\u3001\u671d\u98df\u3084\u663c\u98df\u306b\u7cd6\u8cea\u3092\u6442\u308b\u3068\u4ee3\u8b1d\u304c\u30b9\u30e0\u30fc\u30ba\u306b\u3002<\/li>\n\n\n\n<li><strong>\u5909\u7570\u304c\u306a\u3044\u4eba<\/strong>\uff1a\u98df\u4e8b\u306e\u6642\u9593\u306e\u5f71\u97ff\u306f\u6bd4\u8f03\u7684\u5c11\u306a\u3044\u304c\u3001\u9069\u5207\u306a\u30ea\u30ba\u30e0\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u7cd6\u8cea\u7ba1\u7406\u306e\u5b9f\u8df5<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"768\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/24447461_m-1024x768.jpg\" alt=\"\" class=\"wp-image-9923\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/24447461_m-1024x768.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/24447461_m-300x225.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/24447461_m-768x576.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/24447461_m-1536x1152.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/24447461_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u5206\u304b\u308b\u3053\u3068<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7cd6\u8cea\u306e\u5438\u53ce\u80fd\u529b\uff08AMY1, SLC2A2\uff09<\/li>\n\n\n\n<li>\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\uff08PPARG, IRS1, TCF7L2\uff09<\/li>\n\n\n\n<li>\u98df\u4e8b\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u306e\u5f71\u97ff\uff08CLOCK, BMAL1\uff09<\/li>\n\n\n\n<li>\u7cd6\u8cea\u55dc\u597d\u306e\u907a\u4f1d\u7684\u50be\u5411\uff08FGF21\uff09<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30c0\u30a4\u30a8\u30c3\u30c8\u306e\u30e1\u30ea\u30c3\u30c8<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u81ea\u5206\u306b\u5408\u3063\u305f\u7cd6\u8cea\u6442\u53d6\u91cf\u3092\u628a\u63e1\u3067\u304d\u308b<\/li>\n\n\n\n<li>\u98df\u4e8b\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3092\u6700\u9069\u5316\u3067\u304d\u308b<\/li>\n\n\n\n<li>\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u7406\u89e3\u3057\u3001\u75c5\u6c17\u306e\u4e88\u9632\u306b\u5f79\u7acb\u3066\u308b<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7cd6\u8cea\u4ee3\u8b1d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u305d\u306e\u4ed6\u306e\u91cd\u8981\u306a\u907a\u4f1d\u5b50<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. GCK\u907a\u4f1d\u5b50\uff08\u30b0\u30eb\u30b3\u30ad\u30ca\u30fc\u30bc\u907a\u4f1d\u5b50\uff09<\/strong><\/h3>\n\n\n\n<p>GCK\u907a\u4f1d\u5b50\u306f\u3001\u809d\u81d3\u3084\u81b5\u81d3\u306e\u03b2\u7d30\u80de\u306b\u304a\u3044\u3066\u8840\u7cd6\u30bb\u30f3\u30b5\u30fc\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u30b0\u30eb\u30b3\u30ad\u30ca\u30fc\u30bc\uff08GCK\uff09\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u9175\u7d20\u306f\u3001\u8840\u7cd6\u5024\u306b\u5fdc\u3058\u3066\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u5206\u6ccc\u3092\u8abf\u6574\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>GCK\u907a\u4f1d\u5b50\u306e\u5909\u7570\uff08rs1799884\u5909\u7570\uff09\u304c\u3042\u308b\u3068\u3001\u809d\u81d3\u3067\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u304c\u4f4e\u4e0b\u3057\u3001\u7a7a\u8179\u6642\u8840\u7cd6\u5024\u304c\u9ad8\u304f\u306a\u308a\u3084\u3059\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Diabetologia\uff09\u3002<\/li>\n\n\n\n<li>GCK\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u4f4e\u4e0b\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u671d\u98df\u6642\u306b\u7cd6\u8cea\u3092\u63a7\u3048\u3001\u8840\u7cd6\u5024\u306e\u6025\u4e0a\u6607\u3092\u907f\u3051\u308b\u98df\u4e8b\u6cd5\u304c\u6709\u52b9\u3002<\/li>\n\n\n\n<li><strong>\u5909\u7570\u304c\u306a\u3044\u4eba<\/strong>\uff1a\u7cd6\u8cea\u6442\u53d6\u306b\u5bfe\u3059\u308b\u8010\u6027\u304c\u6bd4\u8f03\u7684\u9ad8\u304f\u3001\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u98df\u4e8b\u304c\u63a8\u5968\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. FABP2\u907a\u4f1d\u5b50\uff08\u8102\u80aa\u9178\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea2\uff09<\/strong><\/h3>\n\n\n\n<p>FABP2\u907a\u4f1d\u5b50\u306f\u3001\u8178\u5185\u3067\u306e\u8102\u80aa\u9178\u3068\u7cd6\u8cea\u306e\u5438\u53ce\u3092\u8abf\u7bc0\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\uff08Ala54Thr\u5909\u7570\uff09\u306f\u3001\u8102\u8cea\u3084\u7cd6\u8cea\u306e\u4ee3\u8b1d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>FABP2 Ala54Thr\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u7cd6\u8cea\u3092\u8102\u80aa\u3068\u3057\u3066\u84c4\u7a4d\u3057\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308b\uff08The Journal of Clinical Endocrinology &amp; Metabolism\uff09\u3002<\/li>\n\n\n\n<li>\u3053\u306e\u5909\u7570\u3092\u6301\u3064\u3068\u3001\u98df\u5f8c\u306e\u8840\u7cd6\u5024\u304c\u9ad8\u304f\u306a\u308a\u3084\u3059\u304f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u8102\u8cea\u4ee3\u8b1d\u3092\u4fc3\u9032\u3059\u308b\u305f\u3081\u306b\u3001\u7cd6\u8cea\u3092\u63a7\u3048\u3064\u3064\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u306e\u6442\u53d6\u3092\u5897\u3084\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5909\u7570\u304c\u306a\u3044\u4eba<\/strong>\uff1a\u901a\u5e38\u306e\u7cd6\u8cea\u6442\u53d6\u3067\u7279\u306b\u554f\u984c\u306f\u306a\u304f\u3001\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u98df\u4e8b\u304c\u6709\u52b9\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. ADRB2\u907a\u4f1d\u5b50\uff08\u03b22\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u53d7\u5bb9\u4f53\uff09<\/strong><\/h3>\n\n\n\n<p>ADRB2\u907a\u4f1d\u5b50\u306f\u3001\u4ea4\u611f\u795e\u7d4c\u306e\u6d3b\u6027\u5316\u3092\u8abf\u7bc0\u3059\u308b\u03b22\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u53d7\u5bb9\u4f53\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u8102\u80aa\u306e\u5206\u89e3\u3084\u7cd6\u8cea\u4ee3\u8b1d\u306b\u3082\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u591a\u578b\uff08Arg16Gly\u5909\u7570\u3001Gln27Glu\u5909\u7570\uff09\u306f\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u3084\u8102\u80aa\u71c3\u713c\u52b9\u7387\u3092\u5909\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ADRB2\u306eArg16Gly\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u304f\u3001\u7cd6\u8cea\u3092\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u3057\u3066\u5229\u7528\u3057\u306b\u304f\u3044\u50be\u5411\u304c\u3042\u308b\uff08Diabetes Journal\uff09\u3002<\/li>\n\n\n\n<li>Gln27Glu\u5909\u7570\u306f\u3001\u57fa\u790e\u4ee3\u8b1d\u7387\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u30c0\u30a4\u30a8\u30c3\u30c8\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Arg16Gly\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u6709\u9178\u7d20\u904b\u52d5\u3092\u5897\u3084\u3057\u3001\u7cd6\u8cea\u4ee3\u8b1d\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u30c0\u30a4\u30a8\u30c3\u30c8\u52b9\u679c\u3092\u5411\u4e0a\u3055\u305b\u308b\u3002<\/li>\n\n\n\n<li><strong>Gln27Glu\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u98df\u4e8b\u306e\u7cd6\u8cea\u91cf\u3092\u6e1b\u3089\u3057\u3001\u8102\u8cea\u4ee3\u8b1d\u3092\u91cd\u8996\u3057\u305f\u98df\u4e8b\u30d7\u30e9\u30f3\u3092\u63a1\u7528\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7cd6\u8cea\u4ee3\u8b1d\u3068\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"724\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/22044179_m-1024x724.jpg\" alt=\"\u30ed\u30dc\u30c3\u30c8\u3068\u9752\u30c6\u30af\u30b9\u30c1\u30e3\" class=\"wp-image-8983\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/22044179_m-1024x724.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/22044179_m-300x212.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/22044179_m-768x543.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/22044179_m-1536x1086.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/22044179_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u7cd6\u8cea\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u3001\u751f\u6d3b\u7fd2\u6163\u3084\u98df\u4e8b\u306b\u3088\u3063\u3066\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u73fe\u8c61\u306f\u300c\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u300d\u3068\u547c\u3070\u308c\u3001\u907a\u4f1d\u5b50\u306e\u30b9\u30a4\u30c3\u30c1\u304c\u5916\u90e8\u8981\u56e0\u306b\u3088\u3063\u3066\u30aa\u30f3\u30fb\u30aa\u30d5\u3055\u308c\u308b\u4ed5\u7d44\u307f\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u30e1\u30c1\u30eb\u5316\u3068\u7cd6\u8cea\u4ee3\u8b1d<\/strong><\/h3>\n\n\n\n<p>DNA\u306e\u30e1\u30c1\u30eb\u5316\u306f\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u91cd\u8981\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u3059\u3002\u7cd6\u8cea\u3092\u904e\u5270\u6442\u53d6\u3059\u308b\u3068\u3001\u7cd6\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306e\u30e1\u30c1\u30eb\u5316\u30d1\u30bf\u30fc\u30f3\u304c\u5909\u5316\u3057\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u306b\u3088\u3063\u3066PPARG\u907a\u4f1d\u5b50\u3084IRS1\u907a\u4f1d\u5b50\u306e\u30e1\u30c1\u30eb\u5316\u304c\u9032\u307f\u3001\u7cd6\u4ee3\u8b1d\u304c\u60aa\u5316\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41467-017-02421-3?utm_source=chatgpt.com\">Nature Communications<\/a>\uff09\u3002<\/li>\n\n\n\n<li>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5909\u5316\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u306f\u628a\u63e1\u3067\u304d\u306a\u3044\u305f\u3081\u3001\u98df\u4e8b\u3084\u904b\u52d5\u3092\u901a\u3058\u3066\u9069\u5207\u306b\u7ba1\u7406\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u7cd6\u8cea\u98df\u304c\u7d9a\u304f\u3068\u4ee3\u8b1d\u304c\u4f4e\u4e0b<\/strong>\uff1a\u7cd6\u8cea\u5236\u9650\u3068\u904b\u52d5\u306e\u7d44\u307f\u5408\u308f\u305b\u3067\u30e1\u30c1\u30eb\u5316\u306e\u5f71\u97ff\u3092\u30ea\u30bb\u30c3\u30c8\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3002<\/li>\n\n\n\n<li><strong>\u98df\u7269\u7e4a\u7dad\u3068\u6297\u9178\u5316\u7269\u8cea\u304c\u30e1\u30c1\u30eb\u5316\u3092\u6291\u5236<\/strong>\uff1a\u91ce\u83dc\u3084\u679c\u7269\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u7cd6\u8cea\u4ee3\u8b1d\u306e\u6539\u5584\u304c\u671f\u5f85\u3067\u304d\u308b\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7cd6\u8cea\u6442\u53d6\u3068\u904b\u52d5\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h2>\n\n\n\n<p>\u7cd6\u8cea\u306e\u5438\u53ce\u3084\u4ee3\u8b1d\u306f\u3001\u904b\u52d5\u306e\u7a2e\u985e\u3084\u5f37\u5ea6\u306b\u3088\u3063\u3066\u3082\u5909\u5316\u3057\u307e\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u904b\u52d5\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u304f\u3001\u7cd6\u8cea\u306e\u5229\u7528\u52b9\u7387\u304c\u5927\u304d\u304f\u5909\u308f\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. ACTN3\u907a\u4f1d\u5b50\u3068\u7cd6\u8cea\u4ee3\u8b1d<\/strong><\/h3>\n\n\n\n<p>ACTN3\u907a\u4f1d\u5b50\u306f\u3001\u901f\u7b4b\u7e4a\u7dad\uff08\u30bf\u30a4\u30d7II\uff09\u306e\u6a5f\u80fd\u306b\u95a2\u4e0e\u3057\u3001\u904b\u52d5\u80fd\u529b\u3084\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u8abf\u7bc0\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u591a\u578b\uff08R577X\u5909\u7570\uff09\u304c\u3042\u308b\u3068\u3001\u7b4b\u8089\u306e\u7cd6\u5229\u7528\u52b9\u7387\u304c\u5909\u5316\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>R577X\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u7cd6\u8cea\u3092\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u3057\u3066\u5229\u7528\u3059\u308b\u80fd\u529b\u304c\u4f4e\u304f\u3001\u6709\u9178\u7d20\u904b\u52d5\u3088\u308a\u3082\u7121\u9178\u7d20\u904b\u52d5\u306e\u65b9\u304c\u9069\u3057\u3066\u3044\u308b\uff08<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00421-017-3575-7?utm_source=chatgpt.com\">European Journal of Applied Physiology<\/a>\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u7b4b\u30c8\u30ec\u3084\u77ed\u6642\u9593\u306e\u9ad8\u5f37\u5ea6\u904b\u52d5\u304c\u7cd6\u8cea\u4ee3\u8b1d\u3092\u6539\u5584\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u5909\u7570\u304c\u306a\u3044\u4eba<\/strong>\uff1a\u6709\u9178\u7d20\u904b\u52d5\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u3001\u7cd6\u8cea\u306e\u52b9\u7387\u7684\u306a\u5229\u7528\u304c\u53ef\u80fd\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7cd6\u8cea\u4ee3\u8b1d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u30db\u30eb\u30e2\u30f3\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"576\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/22814763_m-1024x576.jpg\" alt=\"\" class=\"wp-image-9289\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22814763_m-1024x576.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22814763_m-300x169.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22814763_m-768x432.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22814763_m-1536x864.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22814763_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u7cd6\u8cea\u306e\u5438\u53ce\u3084\u4ee3\u8b1d\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3084\u30b0\u30eb\u30ab\u30b4\u30f3\u306a\u3069\u306e\u30db\u30eb\u30e2\u30f3\u306b\u3088\u3063\u3066\u3082\u8abf\u6574\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30db\u30eb\u30e2\u30f3\u306e\u5206\u6ccc\u3084\u611f\u53d7\u6027\u306b\u306f\u3001\u907a\u4f1d\u5b50\u591a\u578b\u304c\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u30c0\u30a4\u30a8\u30c3\u30c8\u306e\u6210\u529f\u7387\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. INS\u907a\u4f1d\u5b50\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\uff09<\/strong><\/h3>\n\n\n\n<p>INS\u907a\u4f1d\u5b50\u306f\u3001\u81b5\u81d3\u306e\u03b2\u7d30\u80de\u3067\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u5408\u6210\u3092\u8abf\u7bc0\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u591a\u578b\uff08rs689\u5909\u7570\uff09\u304c\u3042\u308b\u3068\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u5206\u6ccc\u304c\u4f4e\u4e0b\u3057\u3001\u8840\u7cd6\u5024\u304c\u9ad8\u304f\u306a\u308a\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>rs689\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u98df\u5f8c\u306e\u8840\u7cd6\u5024\u304c\u9ad8\u304f\u306a\u308a\u3084\u3059\u304f\u3001\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/ng.112?utm_source=chatgpt.com\">Nature Genetics<\/a>\uff09\u3002<\/li>\n\n\n\n<li>\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u304c\u4f4e\u3044\u3068\u3001\u7cd6\u8cea\u306e\u51e6\u7406\u80fd\u529b\u304c\u843d\u3061\u3001\u8102\u80aa\u3068\u3057\u3066\u84c4\u7a4d\u3057\u3084\u3059\u304f\u306a\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u7cd6\u8cea\u306e\u6442\u53d6\u3092\u5206\u6563\u3057\u3001\u4e00\u5ea6\u306b\u5927\u91cf\u306b\u6442\u3089\u306a\u3044\u3088\u3046\u306b\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u5909\u7570\u304c\u306a\u3044\u4eba<\/strong>\uff1a\u901a\u5e38\u306e\u98df\u4e8b\u7ba1\u7406\u3067\u554f\u984c\u306a\u3044\u304c\u3001\u904b\u52d5\u306b\u3088\u3063\u3066\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u6709\u52b9\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. GIPR\u907a\u4f1d\u5b50\uff08\u30a4\u30f3\u30af\u30ec\u30c1\u30f3\u30db\u30eb\u30e2\u30f3\u53d7\u5bb9\u4f53\uff09<\/strong><\/h3>\n\n\n\n<p>GIPR\u907a\u4f1d\u5b50\u306f\u3001\u8178\u7ba1\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308bGIP\uff08\u30b0\u30eb\u30b3\u30fc\u30b9\u4f9d\u5b58\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u523a\u6fc0\u30dd\u30ea\u30da\u30d7\u30c1\u30c9\uff09\u306e\u53d7\u5bb9\u4f53\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002GIP\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u4fc3\u9032\u3057\u3001\u98df\u5f8c\u306e\u8840\u7cd6\u5024\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>rs10423928\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u98df\u5f8c\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u304c\u4f4e\u304f\u3001\u7cd6\u8cea\u4ee3\u8b1d\u304c\u4f4e\u4e0b\u3059\u308b\u50be\u5411\u304c\u3042\u308b\uff08Diabetes\uff09\u3002<\/li>\n\n\n\n<li>\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u8102\u80aa\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u84c4\u7a4d\u80fd\u529b\u304c\u9ad8\u307e\u308a\u3084\u3059\u304f\u3001\u4f53\u8102\u80aa\u306e\u5897\u52a0\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u8840\u7cd6\u5024\u3092\u6025\u6fc0\u306b\u4e0a\u3052\u306a\u3044\u305f\u3081\u306b\u3001\u4f4eGI\u98df\u54c1\u3092\u4e2d\u5fc3\u306b\u6442\u53d6\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u5909\u7570\u304c\u306a\u3044\u4eba<\/strong>\uff1a\u7cd6\u8cea\u306e\u4ee3\u8b1d\u80fd\u529b\u304c\u9ad8\u3044\u305f\u3081\u3001\u7279\u306b\u5236\u9650\u3057\u306a\u304f\u3066\u3082\u554f\u984c\u306a\u3044\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7cd6\u8cea\u306e\u5229\u7528\u52b9\u7387\u3092\u6c7a\u5b9a\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/h2>\n\n\n\n<p>\u7cd6\u8cea\u304c\u5438\u53ce\u3055\u308c\u305f\u5f8c\u3001\u3069\u306e\u3088\u3046\u306b\u5229\u7528\u3055\u308c\u308b\u304b\u306f\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002\u4e00\u90e8\u306e\u4eba\u306f\u7cd6\u8cea\u3092\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u3057\u3066\u3059\u3050\u306b\u4f7f\u3046\u306e\u306b\u5bfe\u3057\u3001\u4ed6\u306e\u4eba\u306f\u8102\u80aa\u3068\u3057\u3066\u84c4\u7a4d\u3057\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. PPARA\u907a\u4f1d\u5b50\uff08\u8102\u8cea\u30fb\u7cd6\u8cea\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u5909\u63db\uff09<\/strong><\/h3>\n\n\n\n<p>PPARA\u907a\u4f1d\u5b50\u306f\u3001\u8102\u80aa\u9178\u306e\u9178\u5316\u3084\u7cd6\u8cea\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u5229\u7528\u306b\u95a2\u4e0e\u3059\u308b\u8ee2\u5199\u56e0\u5b50\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\uff08rs1800206\u5909\u7570\uff09\u304c\u3042\u308b\u3068\u3001\u7cd6\u8cea\u306e\u5229\u7528\u52b9\u7387\u304c\u5909\u5316\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>rs1800206\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u7cd6\u8cea\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u5229\u7528\u52b9\u7387\u304c\u4f4e\u4e0b\u3057\u3001\u8102\u80aa\u3068\u3057\u3066\u84c4\u7a4d\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\uff08The Journal of Lipid Research\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u7cd6\u8cea\u306e\u6442\u53d6\u91cf\u3092\u6291\u3048\u3001\u8102\u8cea\u4ee3\u8b1d\u3092\u6d3b\u6027\u5316\u3059\u308b\u305f\u3081\u306b\u6709\u9178\u7d20\u904b\u52d5\u3092\u5897\u3084\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5909\u7570\u304c\u306a\u3044\u4eba<\/strong>\uff1a\u7cd6\u8cea\u3092\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u3057\u3066\u5229\u7528\u3057\u3084\u3059\u3044\u305f\u3081\u3001\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u98df\u4e8b\u304c\u63a8\u5968\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. UCP2\u907a\u4f1d\u5b50\uff08\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\uff09<\/strong><\/h3>\n\n\n\n<p>UCP2\uff08\u8131\u5171\u5f79\u30bf\u30f3\u30d1\u30af\u8cea2\uff09\u907a\u4f1d\u5b50\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u304a\u3051\u308b\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u3092\u8abf\u6574\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u304c\u4f4e\u4e0b\u3057\u3001\u7cd6\u8cea\u306e\u4ee3\u8b1d\u52b9\u7387\u304c\u5909\u308f\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>rs659366\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u7cd6\u8cea\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u8ee2\u63db\u52b9\u7387\u304c\u4f4e\u304f\u3001\u4f53\u8102\u80aa\u306e\u5897\u52a0\u306b\u3064\u306a\u304c\u308a\u3084\u3059\u3044\uff08<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1871403X17300844?utm_source=chatgpt.com\">Obesity Research &amp; Clinical Practice<\/a>\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u57fa\u790e\u4ee3\u8b1d\u3092\u9ad8\u3081\u308b\u305f\u3081\u306b\u904b\u52d5\u3092\u5897\u3084\u3057\u3001\u98df\u4e8b\u306e\u30ab\u30ed\u30ea\u30fc\u5bc6\u5ea6\u3092\u6291\u3048\u308b\u3002<\/li>\n\n\n\n<li><strong>\u5909\u7570\u304c\u306a\u3044\u4eba<\/strong>\uff1a\u901a\u5e38\u306e\u7cd6\u8cea\u6442\u53d6\u3067\u7279\u306b\u554f\u984c\u306f\u306a\u3044\u304c\u3001\u904e\u98df\u306b\u6ce8\u610f\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u904b\u52d5\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u308b\u7cd6\u8cea\u4ee3\u8b1d\u306e\u6700\u9069\u5316<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"574\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/27441369_m-1024x574.jpg\" alt=\"\u30e9\u30f3\u30cb\u30f3\u30b0\u30de\u30b7\u30f3\u3068\u5973\u6027\" class=\"wp-image-9712\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27441369_m-1024x574.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27441369_m-300x168.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27441369_m-768x430.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27441369_m-1536x861.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27441369_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u907a\u4f1d\u5b50\u306b\u5fdc\u3058\u305f\u904b\u52d5\u306e\u9078\u629e<\/strong><\/h3>\n\n\n\n<p>\u7cd6\u8cea\u306e\u4ee3\u8b1d\u80fd\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u907a\u4f1d\u5b50\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u3001\u6700\u9069\u306a\u904b\u52d5\u65b9\u6cd5\u3082\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u6301\u4e45\u529b\u306b\u5411\u3044\u305f\u907a\u4f1d\u5b50\u30bf\u30a4\u30d7<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ACTN3 R577X\u5909\u7570\uff08\u901f\u7b4b\u7e4a\u7dad\u306e\u767a\u9054\u306b\u5f71\u97ff\uff09<\/strong><\/li>\n\n\n\n<li><strong>UCP2\u5909\u7570\uff08\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u306e\u4f4e\u4e0b\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u63a8\u5968\u3055\u308c\u308b\u904b\u52d5<\/strong>\uff1a\u6709\u9178\u7d20\u904b\u52d5\uff08\u30e9\u30f3\u30cb\u30f3\u30b0\u3001\u30b5\u30a4\u30af\u30ea\u30f3\u30b0\u306a\u3069\uff09<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306b\u5411\u3044\u305f\u907a\u4f1d\u5b50\u30bf\u30a4\u30d7<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PPARA\u5909\u7570\uff08\u8102\u80aa\u9178\u9178\u5316\u306e\u4f4e\u4e0b\uff09<\/strong><\/li>\n\n\n\n<li><strong>ADRB2\u5909\u7570\uff08\u03b22\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u53d7\u5bb9\u4f53\u306e\u5f71\u97ff\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u63a8\u5968\u3055\u308c\u308b\u904b\u52d5<\/strong>\uff1a\u9ad8\u5f37\u5ea6\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08HIIT\uff09\u3001\u30a6\u30a7\u30a4\u30c8\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7cd6\u8cea\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308b\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3068\u907a\u4f1d\u5b50\u306e\u5f71\u97ff<\/strong><\/h2>\n\n\n\n<p>\u7cd6\u8cea\u306e\u6442\u53d6\u3084\u4ee3\u8b1d\u306f\u3001\u5358\u306b\u6d88\u5316\u5668\u7cfb\u3084\u30db\u30eb\u30e2\u30f3\u306e\u50cd\u304d\u3060\u3051\u3067\u306a\u304f\u3001\u8133\u5185\u306e\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306b\u3088\u3063\u3066\u3082\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002\u7279\u306b\u30c9\u30fc\u30d1\u30df\u30f3\u3084\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u5206\u6ccc\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u306e\u9055\u3044\u304c\u3001\u7cd6\u8cea\u306e\u55dc\u597d\u3084\u98df\u6b32\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. DRD2\u907a\u4f1d\u5b50\uff08\u30c9\u30fc\u30d1\u30df\u30f3\u53d7\u5bb9\u4f53\u907a\u4f1d\u5b50\uff09<\/strong><\/h3>\n\n\n\n<p>\u30c9\u30fc\u30d1\u30df\u30f3\u306f\u5feb\u697d\u3084\u5831\u916c\u7cfb\u306b\u95a2\u4e0e\u3059\u308b\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3067\u3042\u308a\u3001\u7cd6\u8cea\u6442\u53d6\u306b\u3088\u308b\u6e80\u8db3\u611f\u3084\u4f9d\u5b58\u306b\u95a2\u308f\u308a\u307e\u3059\u3002DRD2\u907a\u4f1d\u5b50\u306e\u591a\u578b\u304c\u3042\u308b\u3068\u3001\u7cd6\u8cea\u3078\u306e\u4f9d\u5b58\u5ea6\u304c\u9ad8\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>DRD2 TaqIA\uff08rs1800497\uff09\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u7cd6\u8cea\u3084\u9ad8\u30ab\u30ed\u30ea\u30fc\u98df\u54c1\u306b\u5bfe\u3059\u308b\u5831\u916c\u7cfb\u306e\u611f\u53d7\u6027\u304c\u9ad8\u307e\u308a\u3001\u904e\u5270\u6442\u53d6\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308b\uff08<a href=\"https:\/\/www.nature.com\/articles\/nn1235?utm_source=chatgpt.com\">Nature Neuroscience<\/a>\uff09\u3002<\/li>\n\n\n\n<li>\u3053\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u98df\u4e8b\u306e\u6e80\u8db3\u611f\u3092\u5f97\u308b\u305f\u3081\u306b\u3001\u7cd6\u8cea\u3084\u8102\u80aa\u306e\u6442\u53d6\u91cf\u304c\u5897\u3048\u308b\u50be\u5411\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u7cd6\u8cea\u306e\u904e\u5270\u6442\u53d6\u3092\u9632\u3050\u305f\u3081\u306b\u3001\u9ad8\u30bf\u30f3\u30d1\u30af\u98df\u3084\u4f4eGI\u98df\u54c1\u3092\u53d6\u308a\u5165\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>\u5909\u7570\u304c\u306a\u3044\u4eba<\/strong>\uff1a\u7cd6\u8cea\u306e\u5831\u916c\u7cfb\u3078\u306e\u5f71\u97ff\u304c\u5c11\u306a\u3044\u305f\u3081\u3001\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u98df\u4e8b\u304c\u53ef\u80fd\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. SLC6A4\u907a\u4f1d\u5b50\uff08\u30bb\u30ed\u30c8\u30cb\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u907a\u4f1d\u5b50\uff09<\/strong><\/h3>\n\n\n\n<p>\u30bb\u30ed\u30c8\u30cb\u30f3\u306f\u300c\u5e78\u798f\u30db\u30eb\u30e2\u30f3\u300d\u3068\u3082\u547c\u3070\u308c\u3001\u98df\u6b32\u3084\u6c17\u5206\u306e\u8abf\u6574\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002SLC6A4\u907a\u4f1d\u5b50\u306e\u591a\u578b\uff085-HTTLPR\u5909\u7570\uff09\u306f\u3001\u7cd6\u8cea\u3078\u306e\u55dc\u597d\u3084\u30b9\u30c8\u30ec\u30b9\u6642\u306e\u98df\u884c\u52d5\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>SLC6A4\u306e\u77ed\u7e2e\u578b\uff08S\u578b\uff09\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u6642\u306b\u7cd6\u8cea\u3092\u904e\u5270\u306b\u6442\u53d6\u3057\u3084\u3059\u3044\uff08<a href=\"https:\/\/www.nature.com\/articles\/mp201166?utm_source=chatgpt.com\">Molecular Psychiatry<\/a>\uff09\u3002<\/li>\n\n\n\n<li>\u7cd6\u8cea\u3092\u6442\u308b\u3053\u3068\u3067\u30bb\u30ed\u30c8\u30cb\u30f3\u304c\u5897\u3048\u3001\u4e00\u6642\u7684\u306b\u6c17\u5206\u304c\u826f\u304f\u306a\u308b\u304c\u3001\u904e\u5270\u6442\u53d6\u306b\u3088\u3063\u3066\u8840\u7cd6\u5024\u306e\u4e71\u9ad8\u4e0b\u304c\u751f\u3058\u3084\u3059\u304f\u306a\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30c0\u30a4\u30a8\u30c3\u30c8\u3078\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u77ed\u7e2e\u578b\uff08S\u578b\uff09\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u3092\u610f\u8b58\u3057\u3001\u7cd6\u8cea\u4ee5\u5916\u306e\u30ea\u30e9\u30c3\u30af\u30b9\u624b\u6bb5\uff08\u7791\u60f3\u3001\u904b\u52d5\uff09\u3092\u53d6\u308a\u5165\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>\u9577\u9396\u578b\uff08L\u578b\uff09\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u7cd6\u8cea\u6442\u53d6\u306b\u3088\u308b\u30b9\u30c8\u30ec\u30b9\u904e\u98df\u306e\u5f71\u97ff\u306f\u5c11\u306a\u3044\u305f\u3081\u3001\u9069\u91cf\u3092\u7dad\u6301\u3067\u304d\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>\u307e\u3068\u3081<\/strong><\/p>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306f\u7cd6\u8cea\u306e\u5438\u53ce\u3084\u4ee3\u8b1d\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u500b\u4eba\u3054\u3068\u306b\u6700\u9069\u306a\u98df\u4e8b\u3084\u30c0\u30a4\u30a8\u30c3\u30c8\u65b9\u6cd5\u304c\u7570\u306a\u308a\u307e\u3059\u3002AMY1\u907a\u4f1d\u5b50\u306e\u30b3\u30d4\u30fc\u6570\u306b\u3088\u308b\u6d88\u5316\u80fd\u529b\u306e\u9055\u3044\u3084\u3001GCK\u3084PPARG\u907a\u4f1d\u5b50\u306b\u3088\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306e\u5909\u5316\u3001DRD2\u3084SLC6A4\u304c\u95a2\u4e0e\u3059\u308b\u7cd6\u8cea\u55dc\u597d\u306e\u500b\u4eba\u5dee\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u907a\u4f1d\u7684\u8981\u56e0\u304c\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u81ea\u5206\u306b\u5408\u3063\u305f\u7cd6\u8cea\u7ba1\u7406\u304c\u53ef\u80fd\u3068\u306a\u308a\u3001\u52b9\u679c\u7684\u306a\u30c0\u30a4\u30a8\u30c3\u30c8\u3084\u5065\u5eb7\u7dad\u6301\u306b\u3064\u306a\u304c\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u306f\u3058\u3081\u306b 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