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class=\"wp-block-heading\"><strong>\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u3068\u907a\u4f1d\u5b50\u767a\u73fe\uff1a\u6297\u9178\u5316\u6210\u5206\u304c\u7d30\u80de\u30ec\u30d9\u30eb\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/31388126_m-1-1024x683.jpg\" alt=\"\n\u304a\u3059\u3059\u3081\u3059\u308b\u767d\u8863\u306e\u5973\u6027\" class=\"wp-image-188\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/31388126_m-1-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/31388126_m-1-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/31388126_m-1-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/31388126_m-1-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/31388126_m-1.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u6804\u990a\u7d20\u3084\u690d\u7269\u7531\u6765\u6210\u5206\u304c\u30d2\u30c8\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u306b\u542b\u307e\u308c\u308b\u6297\u9178\u5316\u6210\u5206\u3082\u3001\u5358\u306a\u308b\u7d2b\u5916\u7dda\u30c0\u30e1\u30fc\u30b8\u306e\u9632\u6b62\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u5909\u5316\u3092\u8a98\u5c0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001\u30cb\u30e5\u30fc\u30c8\u30ed\u30c3\u30af\u30b9\u30b5\u30f3\u00ae\u306b\u542b\u307e\u308c\u308b<strong>\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb<\/strong>\u3084<strong>\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u985e<\/strong>\u306b\u306f\u3001<strong>NRF2\uff08Nuclear factor erythroid 2\u2013related factor 2\uff09\u7d4c\u8def<\/strong>\u306e\u6d3b\u6027\u5316\u3092\u901a\u3058\u3066\u3001\u6297\u9178\u5316\u9175\u7d20\uff08\u4f8b\uff1aSOD\u3001\u30ab\u30bf\u30e9\u30fc\u30bc\u3001\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u30da\u30eb\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u306a\u3069\uff09\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3059\u308b\u50cd\u304d\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u7d4c\u8def\u306f\u3001\u7d2b\u5916\u7dda\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u7d30\u80de\u3092\u4fdd\u8b77\u3059\u308b\u4e0a\u3067\u6975\u3081\u3066\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u2705 \u53c2\u8003\u6587\u732e\uff1aHern\u00e1ndez-Ledesma B. et al., 2018<\/p>\n\n\n\n<p>NRF2\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u306f\u3001\u808c\u306e\u8001\u5316\u6291\u5236\u3060\u3051\u3067\u306a\u304f\u3001\u76ae\u819a\u306e\u4fee\u5fa9\u6a5f\u80fd\u3084\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u306e\u6291\u5236\u306b\u3082\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u7d50\u679c\u7684\u306b<strong>\u8272\u7d20\u6c88\u7740\u306e\u4e88\u9632\u3084\u808c\u306e\u5f3e\u529b\u7dad\u6301<\/strong>\u306b\u3082\u8ca2\u732e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>[post_category_custom_html]<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u5c0f\u5150\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u3068\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u306e\u5f71\u97ff<\/strong><\/h2>\n\n\n\n<p>\u5b50\u3069\u3082\u306f\u5927\u4eba\u3068\u6bd4\u8f03\u3057\u3066\u3001<strong>\u7d30\u80de\u5206\u88c2\u306e\u901f\u5ea6\u3084\u4ee3\u8b1d\u56de\u8ee2\u304c\u6d3b\u767a<\/strong>\u3067\u3042\u308a\u3001\u5916\u7684\u74b0\u5883\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u7279\u5fb4\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u6297\u9178\u5316\u6210\u5206\u304c\u3069\u306e\u3088\u3046\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u5909\u5316\u3055\u305b\u308b\u304b\u306f\u3001\u3088\u308a\u7e4a\u7d30\u306b\u6349\u3048\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u73fe\u6642\u70b9\u3067\u306f\u3001\u5b50\u3069\u3082\u3092\u5bfe\u8c61\u306b\u3057\u305f<strong>\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u6442\u53d6\u3068\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u76f8\u95a2<\/strong>\u3092\u8a55\u4fa1\u3057\u305f\u7814\u7a76\u306f\u975e\u5e38\u306b\u5c11\u306a\u3044\u3082\u306e\u306e\u3001\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u306f\u3001\u6297\u9178\u5316\u7269\u8cea\u306e\u65e9\u671f\u6442\u53d6\u304c\u767a\u80b2\u671f\u306e\u7d30\u80de\u4fdd\u8b77\u6a5f\u69cb\u3092\u5f37\u5316\u3059\u308b\u3068\u3044\u3046\u5831\u544a\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u2705 \u53c2\u8003\u6587\u732e\uff1aYang Y. et al., 2019<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306a\u77e5\u898b\u3092\u8e0f\u307e\u3048\u308b\u3068\u3001\u300c\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u300d\u3092\u5358\u306a\u308b\u7f8e\u5bb9\u30a2\u30a4\u30c6\u30e0\u3068\u3057\u3066\u3067\u306f\u306a\u304f\u3001\u300c\u4e88\u9632\u533b\u5b66\u7684\u89b3\u70b9\u300d\u304b\u3089\u8a55\u4fa1\u3059\u308b\u7814\u7a76\u306e\u91cd\u8981\u6027\u304c\u5897\u3057\u3066\u3044\u308b\u3068\u8a00\u3048\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p>[post_category_custom_html]<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u7684\u591a\u578b\u3068\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u306e\u76f8\u6027\uff1a\u500b\u5225\u5316\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u53ef\u80fd\u6027<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/31213105_m-1024x683.jpg\" alt=\"\n\u304a\u3059\u3059\u3081\u3059\u308b\u767d\u8863\u306e\u5973\u6027\" class=\"wp-image-189\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/31213105_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/31213105_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/31213105_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/31213105_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/31213105_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u3055\u3089\u306b\u6ce8\u76ee\u3057\u305f\u3044\u306e\u304c\u3001\u907a\u4f1d\u7684\u591a\u578b\uff08genetic polymorphism\uff09\u3068\u306e\u95a2\u4fc2\u3067\u3059\u3002\u4eba\u306b\u3088\u3063\u3066\u306f\u3001\u6297\u9178\u5316\u6210\u5206\u306e\u4ee3\u8b1d\u52b9\u7387\u3084\u5438\u53ce\u7387\u304c\u7570\u306a\u308b\u305f\u3081\u3001<strong>\u540c\u3058\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3067\u3082\u52b9\u679c\u304c\u5927\u304d\u304f\u7570\u306a\u308b<\/strong>\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305f\u3068\u3048\u3070\u3001<strong>GSTT1\u3084GSTM1\u907a\u4f1d\u5b50\u306e\u6b20\u5931\u578b<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u95a2\u9023\u9175\u7d20\u304c\u4e0d\u8db3\u3059\u308b\u305f\u3081\u3001\u7d2b\u5916\u7dda\u306b\u5bfe\u3057\u3066\u3088\u308a\u8106\u5f31\u3067\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u4eba\u3005\u306b\u3068\u3063\u3066\u306f\u3001\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u306e\u88dc\u52a9\u7684\u306a\u6297\u9178\u5316\u30b5\u30dd\u30fc\u30c8\u304c\u6709\u76ca\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5c06\u6765\u7684\u306b\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3068\u9023\u52d5\u3057\u305f<strong>\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9UV\u30b1\u30a2<\/strong>\u304c\u4e00\u822c\u5316\u3059\u308b\u53ef\u80fd\u6027\u3082\u3042\u308a\u3001\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u5e02\u5834\u306b\u65b0\u305f\u306a\u9032\u5316\u3092\u3082\u305f\u3089\u3059\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>[post_category_custom_html]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u6d77\u5916\u306b\u304a\u3051\u308b\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u306e\u898f\u5236\u3068\u8a8d\u53ef\uff1a\u65e5\u672c\u3068\u306e\u9055\u3044\u3068\u306f\uff1f<\/strong><\/h2>\n\n\n\n<p>\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u306f\u65e5\u672c\u56fd\u5185\u3067\u306f\u300c\u6a5f\u80fd\u6027\u8868\u793a\u98df\u54c1\u300d\u3084\u300c\u5065\u5eb7\u88dc\u52a9\u98df\u54c1\u300d\u3068\u3057\u3066\u8ca9\u58f2\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u304c\u3001\u56fd\u306b\u3088\u3063\u3066\u306f\u305d\u306e\u5206\u985e\u3084\u898f\u5236\u304c\u7570\u306a\u308a\u307e\u3059\u3002\u3068\u304f\u306b\u3001**\u30a2\u30e1\u30ea\u30ab\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff08FDA\uff09\u3084\u6b27\u5dde\u98df\u54c1\u5b89\u5168\u6a5f\u95a2\uff08EFSA\uff09**\u306f\u3001\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u306b\u5bfe\u3057\u3066\u660e\u78ba\u306a\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3092\u8a2d\u3051\u3066\u3044\u308b\u3053\u3068\u3067\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305f\u3068\u3048\u3070\u3001\u30a2\u30e1\u30ea\u30abFDA\u306f2018\u5e74\u306b\u3001\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u3092\u540d\u4e57\u308b\u3044\u304f\u3064\u304b\u306e\u88fd\u54c1\u306b\u5bfe\u3057\u3066\u300c\u6d88\u8cbb\u8005\u3092\u8aa4\u89e3\u3055\u305b\u308b\u300d\u3068\u3057\u3066\u8b66\u544a\u66f8\u3092\u767a\u884c\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u5916\u7528\u306e\u65e5\u713c\u3051\u6b62\u3081\u3068\u540c\u7b49\u306e\u52b9\u679c\u3092\u3046\u305f\u3063\u3066\u3044\u305f\u3053\u3068\u304c\u300c\u85ac\u52b9\u8868\u793a\u300d\u306b\u3042\u305f\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3055\u308c\u305f\u305f\u3081\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u2705 \u53c2\u8003\u30ea\u30f3\u30af\uff1aFDA Issues Warning Letters to Companies Marketing Unapproved Sunscreen Products<\/p>\n\n\n\n<p>\u4e00\u65b9\u3001EU\u3067\u306f\u30cb\u30e5\u30fc\u30c8\u30ed\u30c3\u30af\u30b9\u30b5\u30f3\u00ae\u306a\u3069\u306e\u5929\u7136\u7531\u6765\u306e\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u88fd\u54c1\u306b\u5bfe\u3057\u3066\u306f\u3001\u4e00\u5b9a\u306e\u5b89\u5168\u6027\u304c\u8a8d\u3081\u3089\u308c\u3066\u304a\u308a\u3001\u300c\u7f8e\u5bb9\u76ee\u7684\u306e\u6297\u9178\u5316\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u300d\u3068\u3057\u3066\u5e83\u304f\u6d41\u901a\u3057\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u3001<strong>\u300cUV\u9632\u5fa1\u300d\u3068\u3057\u3066\u306e\u52b9\u679c\u8868\u793a\u306f\u5236\u9650\u3055\u308c\u3066\u3044\u308b<\/strong>\u305f\u3081\u3001\u3042\u304f\u307e\u3067\u88dc\u52a9\u7684\u30fb\u7f8e\u5bb9\u7684\u52b9\u679c\u306b\u3068\u3069\u3081\u308b\u8868\u73fe\u304c\u539f\u5247\u3067\u3059\u3002<\/p>\n\n\n\n<p>[post_category_custom_html]<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u5b50\u3069\u3082\u5411\u3051\u306e\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u306f\u5b58\u5728\u3059\u308b\u304b\uff1f\u4e16\u754c\u306e\u4e8b\u4f8b<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/5173842_m-1024x683.jpg\" alt=\"\n\u5bdd\u8ee2\u3076\u8d64\u3061\u3083\u3093\u3092\u898b\u3064\u3081\u308b\u8d64\u3061\u3083\u3093\" class=\"wp-image-194\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/5173842_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/5173842_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/5173842_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/5173842_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/5173842_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" 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Health Products\uff09\u5236\u5ea6<\/strong>\u306b\u57fa\u3065\u304d\u3001\u4e73\u5e7c\u5150\u5411\u3051\u88fd\u54c1\u306b\u306f\u7279\u5225\u306a\u7533\u8acb\u30d7\u30ed\u30bb\u30b9\u304c\u5fc5\u8981\u3067\u3059\u3002\u6297\u9178\u5316\u6210\u5206\u304c\u542b\u307e\u308c\u3066\u3044\u3066\u3082\u3001\u6295\u4e0e\u91cf\u3084\u4ee3\u8b1d\u7d4c\u8def\u306b\u95a2\u3057\u3066\u5341\u5206\u306a\u30c7\u30fc\u30bf\u304c\u5fc5\u8981\u3068\u306a\u308b\u305f\u3081\u3001\u958b\u767a\u304c\u9032\u307f\u306b\u304f\u3044\u306e\u304c\u73fe\u72b6\u3067\u3059\u3002<\/p>\n\n\n\n<p>[post_category_custom_html]<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 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https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/31901249_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/31901249_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u601d\u6625\u671f\u306e\u5b50\u3069\u3082\u304c\u62b1\u3048\u308b\u300c\u7d2b\u5916\u7dda\u5bfe\u7b56\u306e\u8ab2\u984c\u300d\u306f\u4ee5\u4e0b\u306e\u70b9\u306b\u96c6\u7d04\u3055\u308c\u307e\u3059\uff1a<\/p>\n\n\n\n<ol 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class=\"wp-block-heading\"><strong>\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u3068\u98df\u80b2\u306e\u63a5\u70b9\uff1a\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u6559\u80b2\u306e\u91cd\u8981\u6027<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/4446199_m-1024x683.jpg\" alt=\"\n\u30ac\u30e9\u30b9\u5bb9\u5668\u306b\u5165\u3063\u305f\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\" class=\"wp-image-196\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/4446199_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/4446199_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/4446199_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/4446199_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/4446199_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" 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sizes=\"(max-width: 1024px) 100vw, 1024px\" 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class=\"wp-block-heading\"><strong>\u5b50\u3069\u3082\u7279\u6709\u306e\u4ee3\u8b1d\u6a5f\u80fd\u3068\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u6210\u5206\u306e\u95a2\u4fc2\u6027<\/strong><\/h3>\n\n\n\n<p>\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u306e\u6210\u5206\u306f\u3001\u30d3\u30bf\u30df\u30f3\u985e\u3084\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306a\u3069\u306e\u690d\u7269\u7531\u6765\u6210\u5206\u304c\u4e2d\u5fc3\u3067\u3042\u308a\u3001\u4e00\u822c\u7684\u306b\u306f\u300c\u5b89\u5168\u6027\u304c\u9ad8\u3044\u300d\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u5b50\u3069\u3082\u306b\u3053\u308c\u3089\u306e\u6210\u5206\u3092\u6295\u4e0e\u3059\u308b\u5834\u5408\u3001\u300c\u5927\u4eba\u3068\u540c\u3058\u3088\u3046\u306b\u4ee3\u8b1d\u3055\u308c\u308b\u304b\u3069\u3046\u304b\u300d\u3068\u3044\u3046\u8996\u70b9\u304c\u975e\u5e38\u306b\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305a\u524d\u63d0\u3068\u3057\u3066\u3001<strong>\u5b50\u3069\u3082\u306f\u5927\u4eba\u306e\u30df\u30cb\u30c1\u30e5\u30a2\u3067\u306f\u306a\u3044<\/strong>\u3068\u3044\u3046\u8003\u3048\u65b9\u304c\u3042\u308a\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u5358\u7d14\u306b\u4f53\u91cd\u6bd4\u3067\u63db\u7b97\u3057\u305f\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u6442\u53d6\u91cf\u3067\u306f\u3001\u5b89\u5168\u3068\u306f\u8a00\u3044\u5207\u308c\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u5c0f\u5150\u306e\u4f53\u5185\u74b0\u5883\u3001\u7279\u306b\u6d88\u5316\u30fb\u5438\u53ce\u30fb\u4ee3\u8b1d\u30fb\u6392\u6cc4\uff08\u3044\u308f\u3086\u308bADME\uff09\u306e\u5404\u904e\u7a0b\u306b\u306f\u3001\u767a\u9054\u6bb5\u968e\u306b\u5fdc\u3058\u305f\u7279\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>[post_category_custom_html]<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u6d88\u5316\u30fb\u5438\u53ce\uff1a\u8178\u7ba1\u6a5f\u80fd\u3068\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u672a\u6210\u719f<\/strong><\/h4>\n\n\n\n<p>\u5e7c\u5150\u3084\u5c0f\u5b66\u751f\u306e\u8178\u5185\u74b0\u5883\u306f\u3001\u5927\u4eba\u3068\u6bd4\u8f03\u3057\u3066\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u9055\u3044\u3092\u6301\u3063\u3066\u3044\u307e\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6d88\u5316\u9175\u7d20\u306e\u5206\u6ccc\u91cf\u304c\u5c11\u306a\u3044<\/strong><strong><br><\/strong><\/li>\n\n\n\n<li><strong>\u8178\u7c98\u819c\u306e\u900f\u904e\u6027\u304c\u9ad8\u304f\u3001\u9078\u629e\u7684\u5438\u53ce\u6a5f\u69cb\u304c\u672a\u767a\u9054<\/strong><strong><br><\/strong><\/li>\n\n\n\n<li><strong>\u8178\u5185\u7d30\u83cc\u53e2\u304c\u5b89\u5b9a\u3057\u3066\u3044\u306a\u3044\uff08\u7279\u306b2\u301c6\u6b73\uff09<\/strong><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u809d\u81d3\u3067\u306e\u4ee3\u8b1d\u9175\u7d20\u6d3b\u6027\uff1aCYP450\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u767a\u9054<\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/156157_m-1024x683.jpg\" alt=\"\u304a\u8179\u3092\u62bc\u3055\u3048\u308b\u5973\u60273\" class=\"wp-image-198\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/156157_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/156157_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/156157_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/156157_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/generio\/wp-content\/uploads\/2025\/05\/156157_m.jpg 1920w\" sizes=\"(max-width: 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\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u6804\u990a\u7d20\u3084\u690d\u7269\u7531\u6765\u6210\u5206\u304c\u30d2\u30c8\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u306b\u542b\u307e\u308c\u308b\u6297\u9178\u5316\u6210\u5206\u3082\u3001\u5358\u306a\u308b\u7d2b\u5916\u7dda\u30c0\u30e1\u30fc\u30b8\u306e\u9632\u6b62\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u5909\u5316\u3092\u8a98\u5c0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u7279\u306b\u3001\u30cb\u30e5\u30fc\u30c8\u30ed\u30c3\u30af\u30b9\u30b5\u30f3\u00ae\u306b\u542b\u307e\u308c\u308b\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3084\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u985e\u306b\u306f\u3001NRF2\uff08Nuclear factor erythroid 2\u2013related factor 2\uff09\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u3092\u901a\u3058\u3066\u3001\u6297\u9178\u5316\u9175\u7d20\uff08\u4f8b\uff1aSOD\u3001\u30ab\u30bf\u30e9\u30fc\u30bc\u3001\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u30da\u30eb\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u306a\u3069\uff09\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3059\u308b\u50cd\u304d\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u7d4c\u8def\u306f\u3001\u7d2b\u5916\u7dda\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u7d30\u80de\u3092\u4fdd\u8b77\u3059\u308b\u4e0a\u3067\u6975\u3081\u3066\u91cd\u8981\u3067\u3059\u3002 \u2705 \u53c2\u8003\u6587\u732e\uff1aHern\u00e1ndez-Ledesma B. et al., 2018 NRF2\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u306f\u3001\u808c\u306e\u8001\u5316\u6291\u5236\u3060\u3051\u3067\u306a\u304f\u3001\u76ae\u819a\u306e\u4fee\u5fa9\u6a5f\u80fd\u3084\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u306e\u6291\u5236\u306b\u3082\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u7d50\u679c\u7684\u306b\u8272\u7d20\u6c88\u7740\u306e\u4e88\u9632\u3084\u808c\u306e\u5f3e\u529b\u7dad\u6301\u306b\u3082\u8ca2\u732e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 [post_category_custom_html] \u5c0f\u5150\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u3068\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u306e\u5f71\u97ff 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\u73fe\u6642\u70b9\u3067\u306f\u3001\u5b50\u3069\u3082\u3092\u5bfe\u8c61\u306b\u3057\u305f\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u6442\u53d6\u3068\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u76f8\u95a2\u3092\u8a55\u4fa1\u3057\u305f\u7814\u7a76\u306f\u975e\u5e38\u306b\u5c11\u306a\u3044\u3082\u306e\u306e\u3001\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u306f\u3001\u6297\u9178\u5316\u7269\u8cea\u306e\u65e9\u671f\u6442\u53d6\u304c\u767a\u80b2\u671f\u306e\u7d30\u80de\u4fdd\u8b77\u6a5f\u69cb\u3092\u5f37\u5316\u3059\u308b\u3068\u3044\u3046\u5831\u544a\u3082\u3042\u308a\u307e\u3059\u3002 \u2705 \u53c2\u8003\u6587\u732e\uff1aYang Y. et al., 2019 \u3053\u306e\u3088\u3046\u306a\u77e5\u898b\u3092\u8e0f\u307e\u3048\u308b\u3068\u3001\u300c\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u300d\u3092\u5358\u306a\u308b\u7f8e\u5bb9\u30a2\u30a4\u30c6\u30e0\u3068\u3057\u3066\u3067\u306f\u306a\u304f\u3001\u300c\u4e88\u9632\u533b\u5b66\u7684\u89b3\u70b9\u300d\u304b\u3089\u8a55\u4fa1\u3059\u308b\u7814\u7a76\u306e\u91cd\u8981\u6027\u304c\u5897\u3057\u3066\u3044\u308b\u3068\u8a00\u3048\u308b\u3067\u3057\u3087\u3046\u3002 [post_category_custom_html] \u907a\u4f1d\u7684\u591a\u578b\u3068\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u306e\u76f8\u6027\uff1a\u500b\u5225\u5316\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u53ef\u80fd\u6027 \u3055\u3089\u306b\u6ce8\u76ee\u3057\u305f\u3044\u306e\u304c\u3001\u907a\u4f1d\u7684\u591a\u578b\uff08genetic polymorphism\uff09\u3068\u306e\u95a2\u4fc2\u3067\u3059\u3002\u4eba\u306b\u3088\u3063\u3066\u306f\u3001\u6297\u9178\u5316\u6210\u5206\u306e\u4ee3\u8b1d\u52b9\u7387\u3084\u5438\u53ce\u7387\u304c\u7570\u306a\u308b\u305f\u3081\u3001\u540c\u3058\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3067\u3082\u52b9\u679c\u304c\u5927\u304d\u304f\u7570\u306a\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002 \u305f\u3068\u3048\u3070\u3001GSTT1\u3084GSTM1\u907a\u4f1d\u5b50\u306e\u6b20\u5931\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u95a2\u9023\u9175\u7d20\u304c\u4e0d\u8db3\u3059\u308b\u305f\u3081\u3001\u7d2b\u5916\u7dda\u306b\u5bfe\u3057\u3066\u3088\u308a\u8106\u5f31\u3067\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u4eba\u3005\u306b\u3068\u3063\u3066\u306f\u3001\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u306e\u88dc\u52a9\u7684\u306a\u6297\u9178\u5316\u30b5\u30dd\u30fc\u30c8\u304c\u6709\u76ca\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u5c06\u6765\u7684\u306b\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3068\u9023\u52d5\u3057\u305f\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9UV\u30b1\u30a2\u304c\u4e00\u822c\u5316\u3059\u308b\u53ef\u80fd\u6027\u3082\u3042\u308a\u3001\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u5e02\u5834\u306b\u65b0\u305f\u306a\u9032\u5316\u3092\u3082\u305f\u3089\u3059\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002 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