{"id":11403,"date":"2025-05-26T01:15:11","date_gmt":"2025-05-26T01:15:11","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/?p=11403"},"modified":"2025-05-29T03:28:19","modified_gmt":"2025-05-29T03:28:19","slug":"coffee-skin-hair-antiaging","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/coffee-skin-hair-antiaging\/","title":{"rendered":"\u30b3\u30fc\u30d2\u30fc\u306e\u529b\u3067\u808c\u3068\u9aea\u3092\u82e5\u3005\u3057\u304f\u4fdd\u3064\u2500\u2500\u79d1\u5b66\u304c\u8a3c\u660e\u3057\u305f\u5929\u7136\u6210\u5206\u306e\u53ef\u80fd\u6027"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u7b2c1\u7ae0\u3000\u30b3\u30fc\u30d2\u30fc\u306e\u679c\u5b9f\u304c\u8a9e\u308b\u7269\u8a9e\u2500\u2500\u300c\u8001\u3044\u300d\u3068\u300c\u7f8e\u300d\u306e\u4ea4\u5dee\u70b9<\/h2>\n\n\n\n<div style=\"height:24px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-content-justification-center is-layout-flex wp-container-core-group-is-layout-1 wp-block-group-is-layout-flex\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/05\/32393157_s.jpg\" alt=\"\u7a93\u969b\u306e\u660e\u308b\u3044\u6728\u88fd\u30c6\u30fc\u30d6\u30eb\u3067\u30b3\u30fc\u30d2\u30fc\u3092\u7247\u624b\u306b\u8aad\u66f8\u3092\u697d\u3057\u3080\u7b11\u9854\u306e\u5973\u6027\uff5c\u30b3\u30fc\u30d2\u30fc\u7531\u6765\u6210\u5206\u306e\u7f8e\u5bb9\u30fb\u5065\u5eb7\u52b9\u679c\u3092\u7d39\u4ecb\u3059\u308b\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u306e\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u30b3\u30e9\u30e0\u7528\u30a4\u30e1\u30fc\u30b8\" class=\"wp-image-11418\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/05\/32393157_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/05\/32393157_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/05\/32393157_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div><\/div>\n\n\n\n<div style=\"height:24px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u8ab0\u3057\u3082\u304c\u77e5\u308b\u98f2\u307f\u7269\u3001\u30b3\u30fc\u30d2\u30fc\u3002\u305d\u306e\u4e00\u676f\u306e\u80cc\u5f8c\u306b\u3001\u60f3\u50cf\u3092\u8d85\u3048\u308b\u751f\u547d\u306e\u7269\u8a9e\u304c\u6f5c\u3093\u3067\u3044\u307e\u3059\u3002\u65e5\u3005\u3001\u79c1\u305f\u3061\u306e\u76ee\u899a\u3081\u3092\u52a9\u3051\u308b\u3053\u306e\u9ed2\u3044\u6db2\u4f53\u306b\u306f\u3001\u5b9f\u306f\u808c\u3084\u9aea\u306e\u8001\u5316\u3092\u9632\u3050\u529b\u304c\u79d8\u3081\u3089\u308c\u3066\u3044\u308b\u306e\u3067\u3059\u3002\u8fd1\u5e74\u3001\u79d1\u5b66\u8005\u305f\u3061\u306f\u30b3\u30fc\u30d2\u30fc\u8c46\u3060\u3051\u3067\u306a\u304f\u3001\u305d\u306e\u300c\u679c\u5b9f\u300d\u3084\u300c\u679c\u76ae\u300d\u306b\u3082\u6ce8\u76ee\u3057\u59cb\u3081\u307e\u3057\u305f\u3002\u305d\u308c\u3089\u306b\u306f\u3001\u6297\u9178\u5316\u7269\u8cea\u3068\u3057\u3066\u77e5\u3089\u308c\u308b\u30ab\u30d5\u30a7\u30a4\u30f3\uff08Caffeine\uff09\u3084\u30af\u30ed\u30ed\u30b2\u30f3\u9178\uff08Chlorogenic acid\uff09\u3068\u3044\u3063\u305f\u6210\u5206\u304c\u8c4a\u5bcc\u306b\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u808c\u306e\u3057\u308f\u3084\u305f\u308b\u307f\u3001\u9aea\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/about_natural-pro\/\">\u8584\u6bdb<\/a>\u3084\u8131\u6bdb\u3068\u3044\u3063\u305f\u52a0\u9f62\u306b\u4f34\u3046\u73fe\u8c61\u306b\u50cd\u304d\u304b\u3051\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u7ae0\u3067\u306f\u3001\u8001\u5316\u3068\u3044\u3046\u751f\u7269\u5b66\u7684\u73fe\u8c61\u304c\u808c\u3068\u9aea\u306b\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u306e\u304b\u3001\u305d\u3057\u3066\u30b3\u30fc\u30d2\u30fc\u306e\u679c\u5b9f\u304c\u3069\u306e\u3088\u3046\u306b\u305d\u308c\u306b\u7acb\u3061\u5411\u304b\u304a\u3046\u3068\u3057\u3066\u3044\u308b\u306e\u304b\u3092\u3001\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u304d\u306a\u304c\u3089\u7d10\u89e3\u3044\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-1-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7b2c2\u7ae0\u3000\u8001\u5316\u3068\u306f\u4f55\u304b\u2500\u2500\u808c\u3068\u9aea\u304c\u4f1d\u3048\u308b\u6642\u9593\u306e\u75d5\u8de1<\/h2>\n\n\n\n<div style=\"height:24px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-content-justification-center is-layout-flex wp-container-core-group-is-layout-2 wp-block-group-is-layout-flex\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/05\/26494165_s.jpg\" alt=\"\u767d\u3044\u30ab\u30c3\u30d7\u3068\u30bd\u30fc\u30b5\u30fc\u306b\u6ce8\u304c\u308c\u305f\u30d6\u30e9\u30c3\u30af\u30b3\u30fc\u30d2\u30fc\u3068\u30b3\u30fc\u30d2\u30fc\u8c46\u3001\u30d5\u30a7\u30a4\u30af\u30b0\u30ea\u30fc\u30f3\u3084\u6728\u88fd\u7d20\u6750\u3067\u6f14\u51fa\u3055\u308c\u305f\u30a6\u30c3\u30c7\u30a3\u306a\u30c6\u30fc\u30d6\u30eb\u4e0a\u306e\u7f8e\u7684\u914d\u7f6e\uff5c\u81ea\u7136\u7d20\u6750\u3068\u30b3\u30fc\u30d2\u30fc\u306e\u7f8e\u5bb9\u30fb\u80b2\u6bdb\u52b9\u679c\u3092\u7279\u96c6\u3059\u308b\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u76e3\u4fee\u30b3\u30e9\u30e0\u7528\u30a4\u30e1\u30fc\u30b8\" class=\"wp-image-11424\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/05\/26494165_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/05\/26494165_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/05\/26494165_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div><\/div>\n\n\n\n<div style=\"height:24px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u52a0\u9f62\u3068\u306f\u3001\u5358\u306a\u308b\u6642\u9593\u306e\u7d4c\u904e\u3067\u306f\u306a\u304f\u3001\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u306e\u5909\u5316\u304c\u7a4d\u307f\u91cd\u306a\u308b\u3053\u3068\u3067\u8d77\u3053\u308b\u73fe\u8c61\u3067\u3059\u3002\u76ae\u819a\u3067\u306f\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u6e1b\u5c11\u3084\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u84c4\u7a4d\u306b\u3088\u3063\u3066\u3001\u3057\u308f\u3084\u304f\u3059\u307f\u3001\u5f3e\u529b\u4f4e\u4e0b\u3068\u3044\u3063\u305f\u75c7\u72b6\u304c\u73fe\u308c\u307e\u3059\u3002\u4e00\u65b9\u3001\u6bdb\u9aea\u3067\u306f\u6bdb\u5305\uff08hair follicle\uff09\u306e\u840e\u7e2e\u3084\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306e\u5909\u5316\u304c\u3001\u6bdb\u306e\u7d30\u3055\u3001\u8131\u6bdb\u3001\u30dc\u30ea\u30e5\u30fc\u30e0\u306e\u4f4e\u4e0b\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u5909\u5316\u306b\u306f\u3001\u5185\u56e0\u6027\uff08intrinsic\uff09\u3068\u5916\u56e0\u6027\uff08extrinsic\uff09\u306e\u8981\u56e0\u304c\u7d61\u3093\u3067\u3044\u307e\u3059\u3002\u524d\u8005\u306f\u907a\u4f1d\u3084\u4ee3\u8b1d\u306e\u5f71\u97ff\u3001\u5f8c\u8005\u306f\u7d2b\u5916\u7dda\uff08UV\uff09\u3084\u5927\u6c17\u6c5a\u67d3\u306a\u3069\u306e\u74b0\u5883\u56e0\u5b50\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u8001\u5316\u3078\u306e\u5bfe\u51e6\u306f\u3053\u308c\u3089\u4e21\u65b9\u306b\u76ee\u3092\u5411\u3051\u308b\u5fc5\u8981\u304c\u3042\u308a\u3001\u5916\u7684\u306a\u30b1\u30a2\u3068\u5185\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u7d71\u5408\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-1-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7b2c3\u7ae0\u3000\u30b3\u30fc\u30d2\u30fc\u30d9\u30ea\u30fc\u30a8\u30ad\u30b9\uff08CBE\uff09\u2500\u2500\u808c\u3068\u9aea\u3092\u5b88\u308b\u81ea\u7136\u306e\u6075\u307f<\/h2>\n\n\n\n<p>\u30bf\u30a4\u30fb\u30c1\u30a7\u30f3\u30e9\u30a4\u770c\u3067\u53ce\u7a6b\u3055\u308c\u305f\u65b0\u9bae\u306a\u30b3\u30fc\u30d2\u30fc\u30d9\u30ea\u30fc\uff08coffee berry\uff09\u306f\u300150%\u30a8\u30bf\u30ce\u30fc\u30eb\u3092\u7528\u3044\u3066\u62bd\u51fa\u3055\u308c\u305f\u5f8c\u3001HPLC\uff08\u9ad8\u901f\u6db2\u4f53\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\uff09\u3068\u3044\u3046\u5206\u6790\u6cd5\u3067\u305d\u306e\u6210\u5206\u304c\u8abf\u3079\u3089\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u4e3b\u6210\u5206\u3068\u3057\u3066\u30af\u30ed\u30ed\u30b2\u30f3\u9178\uff0834.82 \u00b1 0.79 \u03bcg\/mL\uff09\u3068\u30ab\u30d5\u30a7\u30a4\u30f3\uff0822.29 \u00b1 2.73 \u03bcg\/mL\uff09\u304c\u7279\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u30b3\u30fc\u30d2\u30fc\u30d9\u30ea\u30fc\u30a8\u30ad\u30b9\uff08Coffee Berry Extract\uff1aCBE\uff09\u306f\u3001\u4ee5\u4e0b\u306e2\u3064\u306e\u7d30\u80de\u3092\u7528\u3044\u305fin vitro\uff08\u8a66\u9a13\u7ba1\u5185\uff09\u5b9f\u9a13\u306b\u3088\u3063\u3066\u3001\u305d\u306e\u52b9\u679c\u304c\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u30d2\u30c8\u76ae\u819a\u7dda\u7dad\u82bd\u7d30\u80de\uff08Human Dermal Fibroblasts\uff1aHDF\uff09<br><\/li>\n\n\n\n<li>\u30d2\u30c8\u6bdb\u5305\u4e73\u982d\u7d30\u80de\uff08Hair Follicle Dermal Papilla cells\uff1aHFDP\uff09<br><\/li>\n<\/ol>\n\n\n\n<p>\u307e\u305a\u306f\u5b89\u5168\u6027\u3092\u78ba\u304b\u3081\u308b\u305f\u3081\u306bMTT\u30a2\u30c3\u30bb\u30a4\u3068\u547c\u3070\u308c\u308b\u7d30\u80de\u6bd2\u6027\u8a66\u9a13\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001CBE\u306f\u5358\u72ec\u306e\u30ab\u30d5\u30a7\u30a4\u30f3\u3084\u30af\u30ed\u30ed\u30b2\u30f3\u9178\u3088\u308a\u3082\u6bd2\u6027\u304c\u4f4e\u304f\u3001HDF\u304a\u3088\u3073HFDP\u7d30\u80de\u306b\u5bfe\u3057\u3066IC\u2085\u2080\uff08\u534a\u6570\u963b\u5bb3\u6fc3\u5ea6\uff09\u5024\u304c3.08\u304a\u3088\u30733.07 mg\/mL\u3068\u9ad8\u304f\u3001\u7d30\u80de\u3078\u306e\u30c0\u30e1\u30fc\u30b8\u304c\u5c11\u306a\u3044\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001CBE\u3092\u6700\u59271.2 mg\/mL\u307e\u3067\u4f7f\u7528\u3057\u305f\u3068\u304d\u306b\u3001\u4e21\u7d30\u80de\u306e\u5897\u6b96\u4fc3\u9032\u52b9\u679c\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u50b7\u306e\u6cbb\u7652\u3084\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u518d\u69cb\u7bc9\u306b\u95a2\u308f\u308b\u76ae\u819a\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u6d3b\u6027\u304c\u9ad8\u307e\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002\u9aea\u306e\u6210\u9577\u306b\u3068\u3063\u3066\u91cd\u8981\u306a\u4e73\u982d\u7d30\u80de\u3067\u3082\u540c\u69d8\u306b\u5897\u6b96\u304c\u4fc3\u9032\u3055\u308c\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/about_natural-pro\/\">\u8584\u6bdb<\/a>\u4e88\u9632\u3078\u306e\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u6297\u3059\u308b\u529b\u3082\u898b\u9003\u305b\u307e\u305b\u3093\u3002CBE\u306f\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u30b8\u30b9\u30e0\u30bf\u30fc\u30bc\uff08Superoxide Dismutase\uff1aSOD\uff09\u6d3b\u6027\u309274.5%\u307e\u3067\u9ad8\u3081\u3001\u307e\u305f\u4e00\u9178\u5316\u7a92\u7d20\uff08NO\uff09\u751f\u6210\u309263.9%\u6291\u5236\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u7d2b\u5916\u7dda\u3084\u6c5a\u67d3\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u708e\u75c7\u3084\u7d30\u80de\u52a3\u5316\u304b\u3089\u808c\u3068\u6bdb\u6839\u3092\u5b88\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u7b46\u3059\u3079\u304d\u306fMMP-1\uff08\u30b3\u30e9\u30b2\u30ca\u30fc\u30bc\uff09\u306e\u6291\u5236\u7387\u3067\u3001CBE\u306f65.9%\u306e\u9175\u7d20\u6d3b\u6027\u6291\u5236\u3092\u793a\u3057\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u5206\u89e3\u3092\u9632\u3050\u529b\u304c\u4ed6\u306e\u6210\u5206\u3088\u308a\u3082\u9ad8\u3044\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u30015\u03b1-\u9084\u5143\u9175\u7d20\uff085\u03b1-reductase\uff09\u306e\u963b\u5bb3\u7387\u308267.6%\u3068\u3001\u8131\u6bdb\u306e\u539f\u56e0\u3068\u306a\u308b\u30b8\u30d2\u30c9\u30ed\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\uff08DHT\uff09\u306e\u751f\u6210\u3092\u52b9\u679c\u7684\u306b\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u4f5c\u7528\u3082\u89e3\u6790\u3055\u308c\u307e\u3057\u305f\u3002CBE\u306f\u3001\u9aea\u306e\u6210\u9577\u306b\u95a2\u4e0e\u3059\u308b\u4ee5\u4e0b\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>IGF-1\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u6210\u9577\u56e0\u5b501\uff09\uff1a1.69\u500d<br><\/li>\n\n\n\n<li>KGF\uff08\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u6210\u9577\u56e0\u5b50\uff09\uff1a1.58\u500d<br><\/li>\n\n\n\n<li>VEGF\uff08\u8840\u7ba1\u5185\u76ae\u5897\u6b96\u56e0\u5b50\uff09\uff1a1.74\u500d<br><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u56e0\u5b50\u306f\u6bdb\u5305\u306e\u6804\u990a\u4f9b\u7d66\u3084\u7d30\u80de\u5206\u88c2\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u9aea\u306e\u518d\u751f\u3068\u6210\u9577\u306e\u57fa\u76e4\u3068\u306a\u308b\u50cd\u304d\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-1-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7b2c4\u7ae0\u3000\u30b3\u30fc\u30d2\u30fc\u30d1\u30eb\u30d7\u3068\u8d85\u81e8\u754c\u6d41\u4f53\u62bd\u51fa\u306e\u9769\u65b0\u2500\u2500\u5ec3\u68c4\u7269\u304b\u3089\u751f\u307e\u308c\u308b\u672a\u6765\u306e\u30d8\u30a2\u30b1\u30a2<\/h2>\n\n\n\n<p>\u30b3\u30fc\u30d2\u30fc\u306e\u679c\u76ae\u3001\u3059\u306a\u308f\u3061\u300c\u30d1\u30eb\u30d7\u300d\u306f\u3001\u3053\u308c\u307e\u3067\u5ec3\u68c4\u3055\u308c\u3066\u304d\u305f\u526f\u7523\u7269\u3067\u3057\u305f\u304c\u3001\u305d\u3053\u306b\u3082\u9ad8\u6fc3\u5ea6\u306e\u30ab\u30d5\u30a7\u30a4\u30f3\u3001\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3001\u30af\u30ed\u30ed\u30b2\u30f3\u9178\u3001\u30ab\u30c6\u30ad\u30f3\u30ac\u30ec\u30fc\u30c8\u3068\u3044\u3063\u305f\u6a5f\u80fd\u6027\u6210\u5206\u304c\u8c4a\u5bcc\u306b\u542b\u307e\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u30bf\u30a4\u30fb\u30c1\u30a7\u30f3\u30de\u30a4\u7523\u306e\u30a2\u30e9\u30d3\u30ab\u7a2e\u30b3\u30fc\u30d2\u30fc\u30d1\u30eb\u30d7\u3092\u7528\u3044\u3066\u3001\u8d85\u81e8\u754c\u6d41\u4f53\u62bd\u51fa\uff08Supercritical Fluid Extraction\uff1aSFE\uff09\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u65b9\u6cd5\u306f\u3001\u8d85\u81e8\u754c\u72b6\u614b\u306eCO\u2082\u306b\u30a8\u30bf\u30ce\u30fc\u30eb\u3092\u5171\u6eb6\u5a92\u3068\u3057\u3066\u52a0\u3048\u308b\u3053\u3068\u3067\u3001\u71b1\u306b\u5f31\u3044\u6210\u5206\u3092\u52b9\u7387\u3088\u304f\u62bd\u51fa\u3067\u304d\u308b\u3001\u74b0\u5883\u306b\u512a\u3057\u3044\u624b\u6cd5\u3067\u3059\u3002<\/p>\n\n\n\n<p>6\u3064\u306e\u7570\u306a\u308b\u6761\u4ef6\u4e0b\u3067\u62bd\u51fa\u3055\u308c\u305f\u4e2d\u3067\u3082\u3001\u7279\u306b\u512a\u308c\u305f\u7d50\u679c\u3092\u793a\u3057\u305f\u306e\u304c\u300cSFE-4\u300d\u3068\u540d\u4ed8\u3051\u3089\u308c\u305f\u62bd\u51fa\u7269\u3067\u300150%\u30a8\u30bf\u30ce\u30fc\u30eb\u3001500\u30d0\u30fc\u30eb\u3001100\u2103\u300130\u5206\u3068\u3044\u3046\u6761\u4ef6\u3067\u5f97\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u306eSFE-4\u306f\u3001\u30d2\u30c8\u6bdb\u5305\u4e73\u982d\u7d30\u80de\uff08HFDPC\uff09\u306b\u5bfe\u3057\u3066\u6bd2\u6027\u3092\u793a\u3055\u305a\u3001\u7d30\u80de\u306e\u5897\u6b96\u30fb\u79fb\u52d5\u80fd\u529b\u3092\u6709\u610f\u306b\u9ad8\u3081\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001MMP-2\uff08\u57fa\u8cea\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc2\uff09\u309228.5%\u6d3b\u6027\u5316\u3057\u3001\u8840\u7ba1\u65b0\u751f\u3092\u4fc3\u9032\u3059\u308bVEGF\u306e\u767a\u73fe\u91cf\u308219.5\u500d\u306b\u5897\u52a0\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/about_natural-pro\/\">AGA<\/a>\uff08\u7537\u6027\u578b\u8131\u6bdb\u75c7\uff09\u306b\u95a2\u4e0e\u3059\u308bSRD5A1, SRD5A2, SRD5A3\u3068\u3044\u30463\u3064\u306e5\u03b1\u9084\u5143\u9175\u7d20\u907a\u4f1d\u5b50\u3082\u3001\u305d\u308c\u305e\u308c0.25\u500d\u30010.23\u500d\u30010.29\u500d\u306b\u307e\u3067\u767a\u73fe\u304c\u6291\u3048\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u6291\u5236\u529b\u306f\u3001\u65e2\u5b58\u85ac\u3067\u3042\u308b\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u3084\u30c7\u30e5\u30bf\u30b9\u30c6\u30ea\u30c9\u3088\u308a\u3082\u9ad8\u3044\u7d50\u679c\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u9aea\u306e\u518d\u751f\u306b\u95a2\u308f\u308b\u91cd\u8981\u306a\u5206\u5b50\u7d4c\u8def\u3067\u3042\u308bWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u3068\u30bd\u30cb\u30c3\u30af\u30d8\u30c3\u30b8\u30db\u30c3\u30b0\uff08SHH\uff09\u7d4c\u8def\u306b\u304a\u3044\u3066\u3082\u3001SFE-4\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u5f37\u529b\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u4fc3\u9032\u52b9\u679c\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>CTNNB1\uff08\u03b2-\u30ab\u30c6\u30cb\u30f3\uff09\uff1a29.9\u500d<br><\/li>\n\n\n\n<li>SHH\uff1a26.7\u500d<br><\/li>\n\n\n\n<li>SMO\uff1a25.4\u500d<br><\/li>\n\n\n\n<li>GLI1\uff1a14.0\u500d<br><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u5206\u5b50\u306f\u6bdb\u5305\u5e79\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3001\u6bdb\u5e79\u5f62\u6210\u3001\u305d\u3057\u3066\u6bdb\u5468\u671f\uff08anagen\u671f\uff1d\u6210\u9577\u671f\uff09\u306e\u7dad\u6301\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u3067\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-1-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7b2c5\u7ae0\u3000\u30ab\u30d5\u30a7\u30a4\u30f3\u3068\u3044\u3046\u6210\u5206\u2500\u2500\u79d1\u5b66\u306e\u6df1\u90e8\u306b\u3072\u305d\u3080\u529b<\/h2>\n\n\n\n<p>\u30b3\u30fc\u30d2\u30fc\u306e\u9999\u308a\u306b\u5305\u307e\u308c\u308b\u671d\u3001\u79c1\u305f\u3061\u306f\u7121\u610f\u8b58\u306e\u3046\u3061\u306b\u3001\u305d\u306e\u4e00\u676f\u306b\u542b\u307e\u308c\u308b\u7121\u6570\u306e\u5206\u5b50\u305f\u3061\u3068\u5411\u304d\u5408\u3063\u3066\u3044\u307e\u3059\u3002\u306a\u304b\u3067\u3082\u3001\u6700\u3082\u3088\u304f\u77e5\u3089\u308c\u305f\u6210\u5206\u304c\u30ab\u30d5\u30a7\u30a4\u30f3\uff081,3,7-\u30c8\u30ea\u30e1\u30c1\u30eb\u30ad\u30b5\u30f3\u30c1\u30f3\uff09\u3067\u3059\u3002\u3053\u306e\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u306f\u3001\u5358\u306a\u308b\u899a\u9192\u4f5c\u7528\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u76ae\u819a\u3084\u6bdb\u9aea\u306b\u5bfe\u3057\u3066\u3082\u6ce8\u76ee\u3059\u3079\u304d\u751f\u7406\u4f5c\u7528\u3092\u79d8\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8fd1\u5e74\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u306f\u6297\u9178\u5316\u4f5c\u7528\u3084\u6297\u708e\u75c7\u4f5c\u7528\u306b\u52a0\u3048\u3001\u5fae\u5c0f\u5faa\u74b0\u306e\u6539\u5584\u3001\u305d\u3057\u3066\u6bdb\u9aea\u306e\u6210\u9577\u306b\u95a2\u308f\u308b\u7d30\u80de\u4ee3\u8b1d\u306e\u6d3b\u6027\u5316\u3068\u3044\u3063\u305f\u3001\u591a\u9762\u7684\u306a\u52b9\u679c\u3092\u6301\u3064\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u4f5c\u7528\u306e\u6839\u5e95\u306b\u306f\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u304c\u6301\u3064\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u660e\u78ba\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3068\u308a\u308f\u3051\u91cd\u8981\u306a\u306e\u304c\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u306b\u3088\u308b\u30db\u30b9\u30db\u30b8\u30a8\u30b9\u30c6\u30e9\u30fc\u30bc\uff08Phosphodiesterase\uff1aPDE\uff09\u963b\u5bb3\u4f5c\u7528\u3067\u3059\u3002PDE\u306f\u7d30\u80de\u5185\u306e\u74b0\u72b6\u30a2\u30c7\u30ce\u30b7\u30f3\u4e00\u30ea\u30f3\u9178\uff08cyclic AMP\uff1acAMP\uff09\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\u3067\u3042\u308a\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u306f\u3053\u308c\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067cAMP\u306e\u6fc3\u5ea6\u3092\u4e0a\u6607\u3055\u305b\u307e\u3059\u3002cAMP\u306f\u7d30\u80de\u5185\u306e\u91cd\u8981\u306a\u30bb\u30ab\u30f3\u30c9\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fc\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3001\u4ee3\u8b1d\u6d3b\u6027\u306e\u5411\u4e0a\u3001\u6bdb\u5305\u5e79\u7d30\u80de\u306e\u523a\u6fc0\u3001\u305d\u3057\u3066\u6210\u9577\u671f\uff08anagen\u671f\uff09\u306e\u7dad\u6301\u3068\u3044\u3063\u305f\u30d7\u30ed\u30bb\u30b9\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306ecAMP\u306e\u5897\u52a0\u306f\u3001\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bcA\uff08PKA\uff09\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u3001\u6bdb\u5305\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u8abf\u7bc0\u3084\u8840\u6d41\u4fc3\u9032\u306b\u3082\u3064\u306a\u304c\u308a\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u306f\u5358\u306a\u308b\u8868\u5c64\u7684\u306a\u523a\u6fc0\u7269\u3067\u306f\u306a\u304f\u3001\u6bdb\u9aea\u306e\u6210\u9577\u74b0\u5883\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u6574\u3048\u308b\u50cd\u304d\u3092\u6301\u3064\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u3046\u3057\u305f\u7406\u8ad6\u3092\u88cf\u4ed8\u3051\u308b\u304b\u306e\u3088\u3046\u306b\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u306e\u512a\u308c\u305f\u6d78\u900f\u6027\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5916\u7528\u5f8c\u308f\u305a\u304b20\u5206\u4ee5\u5185\u306b\u6bdb\u6839\u306b\u5230\u9054\u3057\u3001\u305d\u306e\u5f8c\u6700\u592748\u6642\u9593\u306b\u308f\u305f\u308a\u6bdb\u5305\u5185\u90e8\u306b\u3068\u3069\u307e\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u90e8\u4f4d\u3067\u306e\u6301\u7d9a\u7684\u306a\u4f5c\u7528\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u306e\u4f5c\u7528\u306f\u6fc3\u5ea6\u4f9d\u5b58\u7684\u3067\u3042\u308b\u3053\u3068\u3082\u7279\u5fb4\u306e\u4e00\u3064\u3067\u3059\u3002\u8a66\u9a13\u7ba1\u5185\u3067\u306e\u7814\u7a76\u3067\u306f\u30010.0001\u301c0.005%\u306e\u6fc3\u5ea6\u3067\u6bdb\u9aea\u306e\u4f38\u9577\u304c\u4fc3\u9032\u3055\u308c\u308b\u4e00\u65b9\u30010.01%\u4ee5\u4e0a\u3067\u306f\u904e\u5270\u306a\u4ee3\u8b1d\u523a\u6fc0\u306b\u3088\u308a\u6210\u9577\u304c\u6291\u5236\u3055\u308c\u308b\u50be\u5411\u304c\u89b3\u5bdf\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u9069\u5ea6\u306a\u523a\u6fc0\u304c\u7d30\u80de\u306e\u6a5f\u80fd\u3092\u9ad8\u3081\u3001\u904e\u5270\u306a\u523a\u6fc0\u304c\u9006\u52b9\u679c\u3092\u3082\u305f\u3089\u3059\u3068\u3044\u3046\u3001\u751f\u7406\u5b66\u306b\u304a\u3051\u308b\u30db\u30eb\u30df\u30b7\u30b9\uff08hormesis\uff09\u3068\u3044\u3046\u6982\u5ff5\u3068\u3082\u4e00\u81f4\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3044\u3066\u3082\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u306e\u52b9\u679c\u304c\u88cf\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u30010.2%\u30ab\u30d5\u30a7\u30a4\u30f3\u6eb6\u6db2\u3092\u4f7f\u7528\u3057\u305f\u88ab\u9a13\u8005\u7fa4\u3068\u30015%\u30df\u30ce\u30ad\u30b7\u30b8\u30eb\u7fa4\u3068\u306e\u6bd4\u8f03\u304c\u884c\u308f\u308c\u3001\u305d\u306e\u7d50\u679c\u3001\u6bdb\u9aea\u306e\u6210\u9577\u91cf\u306f\u307b\u307c\u540c\u7b49\uff0810.6%\u5bfe11.7%\u3001P = 0.574\uff09\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u7fa4\u3067\u306f\u982d\u76ae\u306e\u304b\u3086\u307f\u304c\u6709\u610f\u306b\u8efd\u6e1b\uff08P = 0.003\uff09\u3055\u308c\u305f\u4e00\u65b9\u3001\u30df\u30ce\u30ad\u30b7\u30b8\u30eb\u7fa4\u3067\u306f\u305d\u306e\u52b9\u679c\u304c\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u3046\u3057\u305f\u7d50\u679c\u306f\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u304c\u4f4e\u523a\u6fc0\u304b\u3064\u591a\u6a5f\u80fd\u3067\u3042\u308a\u306a\u304c\u3089\u3001\u5f93\u6765\u306e\u5916\u7528\u85ac\u306b\u5339\u6575\u3059\u308b\u52b9\u679c\u3092\u767a\u63ee\u3057\u5f97\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u6bdb\u5305\u306b\u5c4a\u304d\u3001\u7d30\u80de\u306e\u5185\u5074\u304b\u3089\u6210\u9577\u30b7\u30b0\u30ca\u30eb\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u305d\u306e\u529b\u306f\u3001\u4eca\u5f8c\u306e\u30b9\u30ab\u30eb\u30d7\u30b1\u30a2\u88fd\u54c1\u306b\u304a\u3051\u308b\u4e2d\u6838\u6210\u5206\u3068\u3057\u3066\u306e\u5730\u4f4d\u3092\u78ba\u7acb\u3057\u3066\u3044\u304f\u53ef\u80fd\u6027\u3092\u5341\u5206\u306b\u79d8\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-1-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7b2c6\u7ae0\u3000\u672a\u6765\u3078\u306e\u5c55\u671b\u2500\u2500\u5ec3\u68c4\u7269\u304b\u3089\u751f\u307e\u308c\u308b\u300c\u65b0\u305f\u306a\u7f8e\u300d\u306e\u53ef\u80fd\u6027<\/h2>\n\n\n\n<p>\u672c\u7a3f\u3067\u7d39\u4ecb\u3057\u305f\u4e00\u9023\u306e\u7814\u7a76\u6210\u679c\u306f\u3001\u30b3\u30fc\u30d2\u30fc\u7531\u6765\u6210\u5206\u304c\u3044\u304b\u306b\u3057\u3066\u76ae\u819a\u8001\u5316\u3068\u6bdb\u9aea\u518d\u751f\u306e\u53cc\u65b9\u306b\u591a\u9762\u7684\u306b\u4f5c\u7528\u3057\u3046\u308b\u304b\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u307e\u3059\u3002CBE\u3068SFE-4\u306e\u3044\u305a\u308c\u3082\u304c\u3001\u5358\u306a\u308b\u6297\u9178\u5316\u7269\u8cea\u3067\u306f\u306a\u304f\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u30ec\u30d9\u30eb\u306b\u307e\u3067\u5f71\u97ff\u3092\u53ca\u307c\u3059\u300c\u751f\u7406\u6d3b\u6027\u7269\u8cea\u300d\u3068\u3057\u3066\u3001\u533b\u7642\u30fb\u7f8e\u5bb9\u5206\u91ce\u3067\u306e\u5b9f\u7528\u5316\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u91cd\u8981\u306a\u306e\u306f\u3001\u3053\u308c\u3089\u306e\u6210\u5206\u304c\u300c\u30b3\u30fc\u30d2\u30fc\u7523\u696d\u306e\u526f\u7523\u7269\u300d\u304b\u3089\u5f97\u3089\u308c\u308b\u3068\u3044\u3046\u70b9\u3067\u3059\u3002\u3059\u306a\u308f\u3061\u3001\u74b0\u5883\u306b\u512a\u3057\u304f\u3001\u6301\u7d9a\u53ef\u80fd\u3067\u3001\u7d4c\u6e08\u7684\u306b\u3082\u610f\u7fa9\u6df1\u3044\u7d20\u6750\u306a\u306e\u3067\u3059\u3002\u30b3\u30fc\u30d2\u30fc\u306e\u4e00\u676f\u304c\u3001\u660e\u65e5\u306e\u7f8e\u3057\u3055\u3068\u5065\u5eb7\u3092\u652f\u3048\u308b\u2500\u2500\u305d\u3093\u306a\u672a\u6765\u304c\u3001\u3082\u3046\u3059\u3050\u305d\u3053\u306b\u3042\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-1-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7b2c7\u7ae0\u3000\u88fd\u54c1\u5fdc\u7528\u306e\u53ef\u80fd\u6027\u2500\u2500\u81e8\u5e8a\u304b\u3089\u5316\u7ca7\u54c1\u5e02\u5834\u3078\u3068\u5e83\u304c\u308b\u9053<\/h2>\n\n\n\n<p>\u3053\u3046\u3057\u305f\u79d1\u5b66\u7684\u6210\u679c\u306f\u3059\u3067\u306b\u3001\u5316\u7ca7\u54c1\u304a\u3088\u3073\u30b9\u30ab\u30eb\u30d7\u30b1\u30a2\u696d\u754c\u306b\u304a\u3044\u3066\u9ad8\u3044\u95a2\u5fc3\u3092\u96c6\u3081\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u81ea\u7136\u7531\u6765\u6210\u5206\uff08\u30ca\u30c1\u30e5\u30e9\u30eb\u30a4\u30f3\u30c7\u30a3\u30b0\u30ea\u30a8\u30f3\u30c8\uff09\u3092\u91cd\u8996\u3059\u308b\u6d88\u8cbb\u8005\u5c64\u306e\u5897\u52a0\u306b\u3088\u308a\u3001\u300c\u30b3\u30fc\u30d2\u30fc\u7531\u6765\u30a8\u30ad\u30b9\u3092\u914d\u5408\u3057\u305f\u30b9\u30ad\u30f3\u30b1\u30a2\u3084\u30d8\u30a2\u30b1\u30a2\u88fd\u54c1\u300d\u306f\u65b0\u305f\u306a\u30c8\u30ec\u30f3\u30c9\u306e\u4e2d\u5fc3\u3068\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>CBE\u3084SFE-4\u306e\u7814\u7a76\u304c\u793a\u3059\u30de\u30eb\u30c1\u30bf\u30fc\u30b2\u30c3\u30c8\u52b9\u679c\u2500\u2500\u305f\u3068\u3048\u3070\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u6291\u5236\u3001\u6bdb\u5305\u306e\u518d\u6d3b\u6027\u5316\u3001DHT\u751f\u6210\u306e\u963b\u5bb3\u3001\u76ae\u819a\u69cb\u9020\u306e\u4fdd\u5168\u3001\u8840\u6d41\u4fc3\u9032\u306a\u3069\u2500\u2500\u306f\u3001\u5358\u4e00\u6210\u5206\u3067\u591a\u89d2\u7684\u306a\u8001\u5316\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u304d\u308b\u3068\u3044\u3046\u70b9\u3067\u6975\u3081\u3066\u9b45\u529b\u7684\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u5b9f\u969b\u3001\u3059\u3067\u306b\u5e02\u5834\u306b\u306f\u300c\u30ab\u30d5\u30a7\u30a4\u30f3\u914d\u5408\u30b7\u30e3\u30f3\u30d7\u30fc\u300d\u3084\u300c\u30af\u30ed\u30ed\u30b2\u30f3\u9178\u5165\u308a\u30b9\u30ad\u30f3\u30bb\u30e9\u30e0\u300d\u304c\u767b\u5834\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u591a\u304f\u306e\u88fd\u54c1\u306f\u307e\u3060\u521d\u671f\u6bb5\u968e\u3067\u3042\u308a\u3001\u660e\u78ba\u306a\u81e8\u5e8a\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u51e6\u65b9\u8a2d\u8a08\u304c\u306a\u3055\u308c\u3066\u3044\u306a\u3044\u5834\u5408\u3082\u5c11\u306a\u304f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u3053\u3053\u3067\u91cd\u8981\u3068\u306a\u308b\u306e\u304c\u3001\u88fd\u5264\u79d1\u5b66\uff08formulation science\uff09\u3067\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u306f\u6c34\u6eb6\u6027\u3067\u5206\u5b50\u91cf\u304c194.2 Da\u3068\u6bd4\u8f03\u7684\u5c0f\u3055\u3044\u305f\u3081\u3001\u76ae\u819a\u3078\u306e\u6d78\u900f\u306f\u7406\u8ad6\u7684\u306b\u53ef\u80fd\u3067\u3059\u304c\u3001\u89d2\u8cea\u5c64\uff08stratum corneum\uff09\u3068\u3044\u3046\u76ae\u819a\u306e\u6700\u8868\u5c64\u30d0\u30ea\u30a2\u3092\u901a\u904e\u3059\u308b\u306b\u306f\u3001\u88fd\u5264\u8a2d\u8a08\u4e0a\u306e\u5de5\u592b\u304c\u5fc5\u8981\u3068\u306a\u308a\u307e\u3059\u3002\u305d\u3053\u3067\u6d3b\u8e8d\u3059\u308b\u306e\u304c\u3001\u30ca\u30ce\u30a8\u30de\u30eb\u30b8\u30e7\u30f3\u3001\u30ea\u30dd\u30bd\u30fc\u30e0\u3001\u30de\u30a4\u30af\u30ed\u30a8\u30f3\u30ad\u30e3\u30d7\u30b9\u30ec\u30fc\u30b7\u30e7\u30f3\u3068\u3044\u3063\u305f\u6280\u8853\u3067\u3059\u3002\u3053\u308c\u3089\u306f\u6210\u5206\u306e\u5b89\u5b9a\u6027\u3092\u9ad8\u3081\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u90e8\u4f4d\u3067\u306e\u653e\u51fa\u5236\u5fa1\u3084\u5438\u53ce\u4fc3\u9032\u3092\u5b9f\u73fe\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001AI\u3092\u6d3b\u7528\u3057\u305f\u88fd\u5264\u8a2d\u8a08\u2500\u2500\u305f\u3068\u3048\u3070\u6210\u5206\u76f8\u4e92\u4f5c\u7528\u306e\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3084\u3001\u76ae\u819a\u5185\u62e1\u6563\u6319\u52d5\u306e\u30e2\u30c7\u30eb\u5316\u306a\u3069\u2500\u2500\u306f\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u3084\u30af\u30ed\u30ed\u30b2\u30f3\u9178\u306e\u3088\u3046\u306b\u591a\u6a5f\u80fd\u3067\u8907\u96d1\u306a\u4f5c\u7528\u3092\u3082\u3064\u5929\u7136\u6210\u5206\u306b\u3068\u3063\u3066\u7279\u306b\u6709\u7528\u3067\u3059\u3002\u6700\u9069\u306a\u88fd\u5264\u8a2d\u8a08\u306f\u3001\u5358\u306b\u52b9\u679c\u3092\u9ad8\u3081\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u523a\u6fc0\u6027\u3084\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u306a\u3069\u306e\u526f\u4f5c\u7528\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u308b\u3053\u3068\u306b\u3082\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-1-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7b2c8\u7ae0\u3000\u81e8\u5e8a\u5fdc\u7528\u3068\u5b89\u5168\u6027\u2500\u2500\u300c\u4f7f\u3048\u308b\u79d1\u5b66\u300d\u3078\u306e\u67b6\u3051\u6a4b<\/h2>\n\n\n\n<p>\u30ab\u30d5\u30a7\u30a4\u30f3\u304a\u3088\u3073\u30b3\u30fc\u30d2\u30fc\u7531\u6765\u30a8\u30ad\u30b9\u306f\u3001\u3053\u308c\u307e\u3067\u306b\u5831\u544a\u3055\u308c\u305f\u9650\u308a\u3067\u306f\u3001\u5916\u7528\u306b\u304a\u3051\u308b\u5b89\u5168\u6027\u304c\u9ad8\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u3092\u914d\u5408\u3057\u305f\u982d\u76ae\u7528\u30ed\u30fc\u30b7\u30e7\u30f3\u306b\u304a\u3044\u3066\u306f\u3001\u304b\u3086\u307f\u3001\u8d64\u307f\u3001\u708e\u75c7\u306a\u3069\u306e\u526f\u4f5c\u7528\u306f\u6975\u3081\u3066\u8efd\u5fae\u3067\u3042\u308a\u3001\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3001\u5185\u670d\u3042\u308b\u3044\u306f\u7d4c\u53e3\u6442\u53d6\u306b\u304a\u3051\u308b\u30ab\u30d5\u30a7\u30a4\u30f3\u306e\u904e\u5270\u6442\u53d6\u306f\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3078\u306e\u904e\u5270\u523a\u6fc0\u3001\u4e0d\u7720\u3001\u52d5\u60b8\u3001\u6d88\u5316\u5668\u4e0d\u8abf\u306a\u3069\u306e\u30ea\u30b9\u30af\u3092\u4f34\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u901a\u5e38\u306e\u30b3\u30fc\u30d2\u30fc\u6442\u53d6\uff081\u676f\u3042\u305f\u308a\u7d04130mg\uff09\u3067\u8840\u4e2d\u6fc3\u5ea6\u306f4 mg\/L\u7a0b\u5ea6\u306b\u7559\u307e\u308a\u3001\u6bd2\u6027\u3068\u3055\u308c\u308b33 mg\/L\u306b\u306f\u5230\u5e95\u9054\u3057\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u8fd1\u5e74\u306e\u75ab\u5b66\u8abf\u67fb\u306b\u3088\u308c\u3070\u3001\u9ad8\u30ab\u30d5\u30a7\u30a4\u30f3\u6442\u53d6\u7fa4\u3067\u306f\u975e\u9ed2\u8272\u816b\u76ae\u819a\u304c\u3093\uff08Non-Melanoma Skin Cancer\uff1aNMSC\uff09\u3084\u57fa\u5e95\u7d30\u80de\u764c\uff08Basal Cell Carcinoma\uff1aBCC\uff09\u306e\u767a\u75c7\u7387\u304c20\u301c40%\u4f4e\u4e0b\u3059\u308b\u3068\u3044\u3046\u5831\u544a\u3082\u3042\u308a\u3001\u7d2b\u5916\u7dda\u306b\u3088\u308bDNA\u640d\u50b7\u306b\u5bfe\u3059\u308b\u9632\u5fa1\u6a5f\u69cb\u3068\u3057\u3066\u306e\u30ab\u30d5\u30a7\u30a4\u30f3\u306e\u53ef\u80fd\u6027\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001\u3053\u308c\u3089\u306e\u7814\u7a76\u306e\u591a\u304f\u306f\u89b3\u5bdf\u7814\u7a76\u3067\u3042\u308a\u3001\u56e0\u679c\u95a2\u4fc2\u3092\u8a3c\u660e\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u4eca\u5f8c\u306f\u7121\u4f5c\u70ba\u5316\u4e8c\u91cd\u76f2\u691c\u81e8\u5e8a\u8a66\u9a13\uff08RCT\uff09\u306b\u3088\u3063\u3066\u3001\u660e\u78ba\u306a\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u3044\u305f\u4f7f\u7528\u6307\u91dd\u304c\u78ba\u7acb\u3055\u308c\u308b\u3053\u3068\u304c\u671b\u307e\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-1-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<h2 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class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-1-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7b2c10\u7ae0\u3000\u7d50\u3073\u306b\u4ee3\u3048\u3066\u2500\u2500\u79d1\u5b66\u3068\u81ea\u7136\u306e\u4ea4\u5dee\u70b9\u3067\u51fa\u4f1a\u3046\u7f8e\u3057\u3055<\/h2>\n\n\n\n<p>\u79d1\u5b66\u3068\u306f\u3001\u8907\u96d1\u3067\u591a\u69d8\u306a\u81ea\u7136\u306e\u4e2d\u306b\u300c\u79e9\u5e8f\u300d\u3068\u300c\u53ef\u80fd\u6027\u300d\u3092\u898b\u51fa\u3059\u55b6\u307f\u3067\u3059\u3002\u30b3\u30fc\u30d2\u30fc\u306e\u679c\u5b9f\u3084\u305d\u306e\u76ae\u306b\u79d8\u3081\u3089\u308c\u305f\u5fae\u7d30\u306a\u5206\u5b50\u304c\u3001\u79c1\u305f\u3061\u306e\u808c\u3068\u9aea\u3001\u3072\u3044\u3066\u306f\u5fc3\u306b\u307e\u3067\u30dd\u30b8\u30c6\u30a3\u30d6\u306a\u5f71\u97ff\u3092\u3082\u305f\u3089\u3059\u2500\u2500\u305d\u306e\u767a\u898b\u306f\u3001\u5358\u306b\u7814\u7a76\u5ba4\u306e\u6210\u679c\u3067\u306f\u306a\u304f\u3001\u300c\u79c1\u305f\u3061\u306e\u65e5\u5e38\u300d\u3092\u8c4a\u304b\u306b\u5909\u3048\u308b\u529b\u3092\u79d8\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8001\u5316\u3092\u300c\u6b62\u3081\u308b\u300d\u3053\u3068\u306f\u3067\u304d\u306a\u304f\u3068\u3082\u3001\u305d\u306e\u9032\u884c\u3092\u300c\u7de9\u3084\u304b\u306b\u3057\u3001\u7f8e\u3057\u304f\u5411\u304d\u5408\u3046\u300d\u3053\u3068\u306f\u53ef\u80fd\u3067\u3059\u3002\u305d\u3057\u3066\u3001\u3082\u3057\u305d\u306e\u624b\u52a9\u3051\u3092\u3057\u3066\u304f\u308c\u308b\u306e\u304c\u3001\u6bce\u671d\u306e\u30b3\u30fc\u30d2\u30fc\u306b\u542b\u307e\u308c\u308b\u5929\u7136\u306e\u6075\u307f\u3060\u3068\u3057\u305f\u3089\u2500\u2500\u305d\u308c\u306f\u3001\u307e\u3055\u306b\u4eba\u3068\u81ea\u7136\u304c\u7e54\u308a\u306a\u3059\u7269\u8a9e\u306e\u65b0\u305f\u306a\u7ae0\u306a\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\u3002<\/p>\n\n\n\n<p>\u4eca\u5f8c\u3055\u3089\u306b\u3001CBE\u3084SFE-4\u306b\u95a2\u3059\u308b\u30d2\u30c8\u81e8\u5e8a\u8a66\u9a13\u306e\u9032\u5c55\u3068\u3001\u56fd\u969b\u7684\u306a\u88fd\u54c1\u958b\u767a\u306e\u52d5\u5411\u3092\u898b\u5b88\u308a\u306a\u304c\u3089\u3001\u79c1\u305f\u3061\u6d88\u8cbb\u8005\u3068\u3057\u3066\u3082\u3088\u308a\u8ce2\u304f\u3001\u3088\u308a\u6301\u7d9a\u53ef\u80fd\u306a\u9078\u629e\u3092\u3057\u3066\u3044\u304f\u3053\u3068\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30b3\u30fc\u30d2\u30fc\u306e\u679c\u5b9f\u306f\u3001\u3082\u306f\u3084\u305f\u3060\u306e\u8fb2\u7523\u7269\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u308c\u306f\u3001\u79d1\u5b66\u3068\u81ea\u7136\u3001\u305d\u3057\u3066\u7f8e\u3057\u3055\u306e\u672a\u6765\u3092\u3064\u306a\u3050\u300c\u9375\u300d\u305d\u306e\u3082\u306e\u306a\u306e\u3067\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-1-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.3390\/cosmetics9030066\">Saewan, Nisakorn. \u300cEffect of Coffee Berry Extract on Anti-Aging for Skin and Hair\u2014In Vitro Approach\u300d. <em>Cosmetics<\/em>, vol. 9, no. 3, 2022\u5e746\u6708, p. 66. <em>DOI.org (Crossref)<\/em>, https:\/\/doi.org\/10.3390\/cosmetics9030066.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/foods12224116\">Muangsanguan, Anurak, \u307b\u304b. \u300cHair Growth Promotion and Anti-Hair Loss Effects of By-Products Arabica Coffee Pulp Extracts Using Supercritical Fluid Extraction\u300d. <em>Foods<\/em>, vol. 12, no. 22, 2023\u5e7411\u6708, p. 4116. <em>DOI.org (Crossref)<\/em>, https:\/\/doi.org\/10.3390\/foods12224116.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.4103\/jdds.jdds_52_19\">Visconti, MichaelJ, \u307b\u304b. \u300cTherapeutic Use of Caffeine in Dermatology: A Literature Review\u300d. <em>Journal of Dermatology and Dermatologic Surgery<\/em>, vol. 24, no. 1, 2020\u5e74, p. 18. <em>DOI.org (Crossref)<\/em>, https:\/\/doi.org\/10.4103\/jdds.jdds_52_19.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/molecules30010167\">Szendzielorz, Ewelina, \u3068Radoslaw Spiewak. \u300cCaffeine as an Active Molecule in Cosmetic Products for Hair Loss: Its Mechanisms of Action in the Context of Hair Physiology and Pathology\u300d. <em>Molecules<\/em>, vol. 30, no. 1, 2025\u5e741\u6708, p. 167. <em>DOI.org (Crossref)<\/em>, https:\/\/doi.org\/10.3390\/molecules30010167.<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u7b2c1\u7ae0\u3000\u30b3\u30fc\u30d2\u30fc\u306e\u679c\u5b9f\u304c\u8a9e\u308b\u7269\u8a9e\u2500\u2500\u300c\u8001\u3044\u300d\u3068\u300c\u7f8e\u300d\u306e\u4ea4\u5dee\u70b9 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follicle\uff09\u306e\u840e\u7e2e\u3084\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306e\u5909\u5316\u304c\u3001\u6bdb\u306e\u7d30\u3055\u3001\u8131\u6bdb\u3001\u30dc\u30ea\u30e5\u30fc\u30e0\u306e\u4f4e\u4e0b\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002 \u3053\u308c\u3089\u306e\u5909\u5316\u306b\u306f\u3001\u5185\u56e0\u6027\uff08intrinsic\uff09\u3068\u5916\u56e0\u6027\uff08extrinsic\uff09\u306e\u8981\u56e0\u304c\u7d61\u3093\u3067\u3044\u307e\u3059\u3002\u524d\u8005\u306f\u907a\u4f1d\u3084\u4ee3\u8b1d\u306e\u5f71\u97ff\u3001\u5f8c\u8005\u306f\u7d2b\u5916\u7dda\uff08UV\uff09\u3084\u5927\u6c17\u6c5a\u67d3\u306a\u3069\u306e\u74b0\u5883\u56e0\u5b50\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u8001\u5316\u3078\u306e\u5bfe\u51e6\u306f\u3053\u308c\u3089\u4e21\u65b9\u306b\u76ee\u3092\u5411\u3051\u308b\u5fc5\u8981\u304c\u3042\u308a\u3001\u5916\u7684\u306a\u30b1\u30a2\u3068\u5185\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u7d71\u5408\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u308b\u306e\u3067\u3059\u3002 \u7b2c3\u7ae0\u3000\u30b3\u30fc\u30d2\u30fc\u30d9\u30ea\u30fc\u30a8\u30ad\u30b9\uff08CBE\uff09\u2500\u2500\u808c\u3068\u9aea\u3092\u5b88\u308b\u81ea\u7136\u306e\u6075\u307f \u30bf\u30a4\u30fb\u30c1\u30a7\u30f3\u30e9\u30a4\u770c\u3067\u53ce\u7a6b\u3055\u308c\u305f\u65b0\u9bae\u306a\u30b3\u30fc\u30d2\u30fc\u30d9\u30ea\u30fc\uff08coffee berry\uff09\u306f\u300150%\u30a8\u30bf\u30ce\u30fc\u30eb\u3092\u7528\u3044\u3066\u62bd\u51fa\u3055\u308c\u305f\u5f8c\u3001HPLC\uff08\u9ad8\u901f\u6db2\u4f53\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\uff09\u3068\u3044\u3046\u5206\u6790\u6cd5\u3067\u305d\u306e\u6210\u5206\u304c\u8abf\u3079\u3089\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u4e3b\u6210\u5206\u3068\u3057\u3066\u30af\u30ed\u30ed\u30b2\u30f3\u9178\uff0834.82 \u00b1 0.79 \u03bcg\/mL\uff09\u3068\u30ab\u30d5\u30a7\u30a4\u30f3\uff0822.29 \u00b1 2.73 \u03bcg\/mL\uff09\u304c\u7279\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002 \u3053\u306e\u30b3\u30fc\u30d2\u30fc\u30d9\u30ea\u30fc\u30a8\u30ad\u30b9\uff08Coffee Berry Extract\uff1aCBE\uff09\u306f\u3001\u4ee5\u4e0b\u306e2\u3064\u306e\u7d30\u80de\u3092\u7528\u3044\u305fin vitro\uff08\u8a66\u9a13\u7ba1\u5185\uff09\u5b9f\u9a13\u306b\u3088\u3063\u3066\u3001\u305d\u306e\u52b9\u679c\u304c\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002 \u307e\u305a\u306f\u5b89\u5168\u6027\u3092\u78ba\u304b\u3081\u308b\u305f\u3081\u306bMTT\u30a2\u30c3\u30bb\u30a4\u3068\u547c\u3070\u308c\u308b\u7d30\u80de\u6bd2\u6027\u8a66\u9a13\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001CBE\u306f\u5358\u72ec\u306e\u30ab\u30d5\u30a7\u30a4\u30f3\u3084\u30af\u30ed\u30ed\u30b2\u30f3\u9178\u3088\u308a\u3082\u6bd2\u6027\u304c\u4f4e\u304f\u3001HDF\u304a\u3088\u3073HFDP\u7d30\u80de\u306b\u5bfe\u3057\u3066IC\u2085\u2080\uff08\u534a\u6570\u963b\u5bb3\u6fc3\u5ea6\uff09\u5024\u304c3.08\u304a\u3088\u30733.07 mg\/mL\u3068\u9ad8\u304f\u3001\u7d30\u80de\u3078\u306e\u30c0\u30e1\u30fc\u30b8\u304c\u5c11\u306a\u3044\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002 \u3055\u3089\u306b\u3001CBE\u3092\u6700\u59271.2 mg\/mL\u307e\u3067\u4f7f\u7528\u3057\u305f\u3068\u304d\u306b\u3001\u4e21\u7d30\u80de\u306e\u5897\u6b96\u4fc3\u9032\u52b9\u679c\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u50b7\u306e\u6cbb\u7652\u3084\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u518d\u69cb\u7bc9\u306b\u95a2\u308f\u308b\u76ae\u819a\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u6d3b\u6027\u304c\u9ad8\u307e\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002\u9aea\u306e\u6210\u9577\u306b\u3068\u3063\u3066\u91cd\u8981\u306a\u4e73\u982d\u7d30\u80de\u3067\u3082\u540c\u69d8\u306b\u5897\u6b96\u304c\u4fc3\u9032\u3055\u308c\u3001\u8584\u6bdb\u4e88\u9632\u3078\u306e\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002 \u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u6297\u3059\u308b\u529b\u3082\u898b\u9003\u305b\u307e\u305b\u3093\u3002CBE\u306f\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u30b8\u30b9\u30e0\u30bf\u30fc\u30bc\uff08Superoxide Dismutase\uff1aSOD\uff09\u6d3b\u6027\u309274.5%\u307e\u3067\u9ad8\u3081\u3001\u307e\u305f\u4e00\u9178\u5316\u7a92\u7d20\uff08NO\uff09\u751f\u6210\u309263.9%\u6291\u5236\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u7d2b\u5916\u7dda\u3084\u6c5a\u67d3\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u708e\u75c7\u3084\u7d30\u80de\u52a3\u5316\u304b\u3089\u808c\u3068\u6bdb\u6839\u3092\u5b88\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002 \u7279\u7b46\u3059\u3079\u304d\u306fMMP-1\uff08\u30b3\u30e9\u30b2\u30ca\u30fc\u30bc\uff09\u306e\u6291\u5236\u7387\u3067\u3001CBE\u306f65.9%\u306e\u9175\u7d20\u6d3b\u6027\u6291\u5236\u3092\u793a\u3057\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u5206\u89e3\u3092\u9632\u3050\u529b\u304c\u4ed6\u306e\u6210\u5206\u3088\u308a\u3082\u9ad8\u3044\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u30015\u03b1-\u9084\u5143\u9175\u7d20\uff085\u03b1-reductase\uff09\u306e\u963b\u5bb3\u7387\u308267.6%\u3068\u3001\u8131\u6bdb\u306e\u539f\u56e0\u3068\u306a\u308b\u30b8\u30d2\u30c9\u30ed\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\uff08DHT\uff09\u306e\u751f\u6210\u3092\u52b9\u679c\u7684\u306b\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u306e\u3067\u3059\u3002 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\u30b3\u30fc\u30d2\u30fc\u306e\u679c\u76ae\u3001\u3059\u306a\u308f\u3061\u300c\u30d1\u30eb\u30d7\u300d\u306f\u3001\u3053\u308c\u307e\u3067\u5ec3\u68c4\u3055\u308c\u3066\u304d\u305f\u526f\u7523\u7269\u3067\u3057\u305f\u304c\u3001\u305d\u3053\u306b\u3082\u9ad8\u6fc3\u5ea6\u306e\u30ab\u30d5\u30a7\u30a4\u30f3\u3001\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3001\u30af\u30ed\u30ed\u30b2\u30f3\u9178\u3001\u30ab\u30c6\u30ad\u30f3\u30ac\u30ec\u30fc\u30c8\u3068\u3044\u3063\u305f\u6a5f\u80fd\u6027\u6210\u5206\u304c\u8c4a\u5bcc\u306b\u542b\u307e\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002 \u672c\u7814\u7a76\u3067\u306f\u3001\u30bf\u30a4\u30fb\u30c1\u30a7\u30f3\u30de\u30a4\u7523\u306e\u30a2\u30e9\u30d3\u30ab\u7a2e\u30b3\u30fc\u30d2\u30fc\u30d1\u30eb\u30d7\u3092\u7528\u3044\u3066\u3001\u8d85\u81e8\u754c\u6d41\u4f53\u62bd\u51fa\uff08Supercritical Fluid Extraction\uff1aSFE\uff09\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u65b9\u6cd5\u306f\u3001\u8d85\u81e8\u754c\u72b6\u614b\u306eCO\u2082\u306b\u30a8\u30bf\u30ce\u30fc\u30eb\u3092\u5171\u6eb6\u5a92\u3068\u3057\u3066\u52a0\u3048\u308b\u3053\u3068\u3067\u3001\u71b1\u306b\u5f31\u3044\u6210\u5206\u3092\u52b9\u7387\u3088\u304f\u62bd\u51fa\u3067\u304d\u308b\u3001\u74b0\u5883\u306b\u512a\u3057\u3044\u624b\u6cd5\u3067\u3059\u3002 6\u3064\u306e\u7570\u306a\u308b\u6761\u4ef6\u4e0b\u3067\u62bd\u51fa\u3055\u308c\u305f\u4e2d\u3067\u3082\u3001\u7279\u306b\u512a\u308c\u305f\u7d50\u679c\u3092\u793a\u3057\u305f\u306e\u304c\u300cSFE-4\u300d\u3068\u540d\u4ed8\u3051\u3089\u308c\u305f\u62bd\u51fa\u7269\u3067\u300150%\u30a8\u30bf\u30ce\u30fc\u30eb\u3001500\u30d0\u30fc\u30eb\u3001100\u2103\u300130\u5206\u3068\u3044\u3046\u6761\u4ef6\u3067\u5f97\u3089\u308c\u307e\u3057\u305f\u3002 \u3053\u306eSFE-4\u306f\u3001\u30d2\u30c8\u6bdb\u5305\u4e73\u982d\u7d30\u80de\uff08HFDPC\uff09\u306b\u5bfe\u3057\u3066\u6bd2\u6027\u3092\u793a\u3055\u305a\u3001\u7d30\u80de\u306e\u5897\u6b96\u30fb\u79fb\u52d5\u80fd\u529b\u3092\u6709\u610f\u306b\u9ad8\u3081\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001MMP-2\uff08\u57fa\u8cea\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc2\uff09\u309228.5%\u6d3b\u6027\u5316\u3057\u3001\u8840\u7ba1\u65b0\u751f\u3092\u4fc3\u9032\u3059\u308bVEGF\u306e\u767a\u73fe\u91cf\u308219.5\u500d\u306b\u5897\u52a0\u3057\u307e\u3057\u305f\u3002 \u307e\u305f\u3001AGA\uff08\u7537\u6027\u578b\u8131\u6bdb\u75c7\uff09\u306b\u95a2\u4e0e\u3059\u308bSRD5A1, SRD5A2, SRD5A3\u3068\u3044\u30463\u3064\u306e5\u03b1\u9084\u5143\u9175\u7d20\u907a\u4f1d\u5b50\u3082\u3001\u305d\u308c\u305e\u308c0.25\u500d\u30010.23\u500d\u30010.29\u500d\u306b\u307e\u3067\u767a\u73fe\u304c\u6291\u3048\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u6291\u5236\u529b\u306f\u3001\u65e2\u5b58\u85ac\u3067\u3042\u308b\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u3084\u30c7\u30e5\u30bf\u30b9\u30c6\u30ea\u30c9\u3088\u308a\u3082\u9ad8\u3044\u7d50\u679c\u3068\u306a\u308a\u307e\u3057\u305f\u3002 \u9aea\u306e\u518d\u751f\u306b\u95a2\u308f\u308b\u91cd\u8981\u306a\u5206\u5b50\u7d4c\u8def\u3067\u3042\u308bWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u3068\u30bd\u30cb\u30c3\u30af\u30d8\u30c3\u30b8\u30db\u30c3\u30b0\uff08SHH\uff09\u7d4c\u8def\u306b\u304a\u3044\u3066\u3082\u3001SFE-4\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u5f37\u529b\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u4fc3\u9032\u52b9\u679c\u3092\u793a\u3057\u307e\u3057\u305f\u3002 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