{"id":7317,"date":"2025-03-24T05:21:25","date_gmt":"2025-03-24T05:21:25","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/?p=7317"},"modified":"2025-04-04T01:01:22","modified_gmt":"2025-04-04T01:01:22","slug":"hfd","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/hfd\/","title":{"rendered":"\u305d\u306e\u98df\u751f\u6d3b\u3001\u9aea\u306b\u304d\u3044\u3066\u308b\u304b\u3082\uff1f"},"content":{"rendered":"\n<p class=\"has-text-align-center\"><sup>\u65e5\u3005\u306e\u98df\u4e8b\u3084\u751f\u6d3b\u7fd2\u6163\u304c\u3001\u9aea\u306e\u5143\u6c17\u3084\u808c\u306e\u82e5\u3005\u3057\u3055\u306b\u307e\u3067\u5f71\u97ff\u3059\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u805e\u3044\u305f\u3089\u9a5a\u304f\u3067\u3057\u3087\u3046\u304b\uff1f\u5b9f\u306f\u300c\u80a5\u6e80\u300d\u304c\u3001\u4f53\u306e\u4e2d\u3067\u518d\u751f\u3084\u4fee\u5fa9\u3092\u62c5\u3046\u300c\u5e79\u7d30\u80de\u300d\u306e\u50cd\u304d\u3092\u5f31\u3081\u308b\u3053\u3068\u3067\u3001\u9aea\u304c\u7d30\u304f\u306a\u3063\u305f\u308a\u3001\u898b\u305f\u76ee\u3060\u3051\u3067\u306a\u304f\u5b9f\u969b\u306b\u8001\u3051\u3084\u3059\u304f\u306a\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u7814\u7a76\u306e\u6839\u62e0\u3092\u3082\u3068\u306b\u3001\u80a5\u6e80\u3068\u9aea\u3084\u808c\u306e\u5909\u5316\u306e\u95a2\u4fc2\u3092\u308f\u304b\u308a\u3084\u3059\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/sup><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u80a5\u6e80\u306f\u5e79\u7d30\u80de\u3092\u901a\u3058\u3066\u7d44\u7e54\u306e\u518d\u751f\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b<\/h2>\n\n\n\n<p>\u4e16\u754c\u4e2d\u3067\u80a5\u6e80\u304c\u6df1\u523b\u306a\u5065\u5eb7\u554f\u984c\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u80a5\u6e80\u306f\u30012\u578b\u7cd6\u5c3f\u75c5\uff08type 2 diabetes mellitus\uff09\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\uff08cardiovascular disease\uff09\u3001\u9ad8\u8840\u5727\uff08hypertension\uff09\u306a\u3069\u306e\u4ee3\u8b1d\u6027\u75be\u60a3\u3068\u5f37\u304f\u95a2\u9023\u3057\u3066\u3044\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u8001\u5316\u306e\u52a0\u901f\u3084\u3001\u3055\u307e\u3056\u307e\u306a\u81d3\u5668\u306b\u304a\u3051\u308b\u7d44\u7e54\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3068\u3082\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u307e\u3067\u306e\u75ab\u5b66\u7684\uff08\u591a\u304f\u306e\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7d71\u8a08\u7684\u306a\u7814\u7a76\uff09\u3084\u81e8\u5e8a\u7684\u306a\u7814\u7a76\u306b\u3088\u308a\u3001\u80a5\u6e80\u3068\u5065\u5eb7\u554f\u984c\u306e\u95a2\u4fc2\u306f\u660e\u3089\u304b\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u304c\u3001\u306a\u305c\u904e\u5270\u306a\u8102\u80aa\u304c\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u7d44\u7e54\u306e\u5b89\u5b9a\u6027\uff08\u6052\u5e38\u6027\uff09\u3092\u58ca\u3059\u306e\u304b\u3001\u305d\u306e\u6b63\u78ba\u306a\u4ed5\u7d44\u307f\u306b\u3064\u3044\u3066\u306f\u3001\u307e\u3060\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u70b9\u304c\u591a\u304f\u6b8b\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-2-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<p>\u7279\u306b\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u306e\u306f\u3001\u80a5\u6e80\u304c\u8eab\u4f53\u306e\u4e2d\u306b\u3042\u308b\u300c\u6210\u4f53\u5e79\u7d30\u80de\uff08adult stem cells\uff09\u300d\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u5e79\u7d30\u80de\u306f\u3001\u50b7\u3064\u3044\u305f\u7d44\u7e54\u3092\u4fee\u5fa9\u3057\u305f\u308a\u3001\u53e4\u304f\u306a\u3063\u305f\u7d30\u80de\u3092\u65b0\u3057\u304f\u5165\u308c\u66ff\u3048\u305f\u308a\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u5e79\u7d30\u80de\u306e\u6a5f\u80fd\u304c\u843d\u3061\u308b\u3068\u3001\u81d3\u5668\u5168\u4f53\u306e\u518d\u751f\u529b\u304c\u4e0b\u304c\u3063\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"360\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/26497529_s.jpg\" alt=\"\u30d4\u30c3\u30b6\u30fc\" class=\"wp-image-7356\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/26497529_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/26497529_s-300x169.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/26497529_s-485x273.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u9aea\u306e\u6839\u5143\u306b\u3042\u308b\u300c\u6bdb\u5305\u300d\u3068\u306f\uff1f \u305d\u3053\u306b\u3042\u308b\u5e79\u7d30\u80de\u306f\u3069\u3093\u306a\u50cd\u304d\u3092\u3057\u3066\u3044\u308b\u306e\uff1f<\/h2>\n\n\n\n<p>\u8001\u5316\u3084\u80a5\u6e80\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u300c\u30df\u30cb\u81d3\u5668\u300d\u306e\u4ee3\u8868\u304c\u3001\u6bdb\u306e\u6839\u5143\u306b\u3042\u308b\u300c\u6bdb\u5305\uff08\u3082\u3046\u307b\u3046\uff0fhair follicle\uff09\u300d\u3067\u3059\u3002\u6bdb\u5305\u306f\u3001\u9aea\u306e\u6bdb\u306e\u751f\u3048\u5909\u308f\u308a\u3092\u652f\u3048\u308b\u975e\u5e38\u306b\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u306a\u69cb\u9020\u3092\u6301\u3063\u3066\u304a\u308a\u3001\u4e00\u751f\u306e\u9593\u306b\u300c\u9000\u884c\u671f\uff08catagen\uff09\u300d\u300c\u4f11\u6b62\u671f\uff08telogen\uff09\u300d\u300c\u6210\u9577\u671f\uff08anagen\uff09\u300d\u3068\u3044\u30463\u3064\u306e\u5468\u671f\u3092\u7e70\u308a\u8fd4\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3046\u3061\u3001\u5b9f\u969b\u306b\u9aea\u304c\u4f38\u3073\u308b\u306e\u306f\u300c\u6210\u9577\u671f\uff08anagen\uff09\u300d\u3067\u3042\u308a\u3001\u3053\u306e\u6642\u671f\u306b\u7279\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u306e\u304c\u300c\u6bdb\u5305\u5e79\u7d30\u80de\uff08hair follicle stem cells\uff1aHFSCs\uff09\u300d\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"360\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/32117209_s-1.jpg\" alt=\"\u307d\u3053\u3093\" class=\"wp-image-6994\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/32117209_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/32117209_s-1-300x169.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/32117209_s-1-485x273.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>HFSCs\u306f\u3001\u6bdb\u5305\u306e\u4e2d\u306b\u3042\u308b\u300c\u30d0\u30eb\u30b8\u9818\u57df\uff08bulge region\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u7279\u5b9a\u306e\u5834\u6240\u306b\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\u3002\u901a\u5e38\u306f\u7720\u3063\u3066\u3044\u308b\u3088\u3046\u306a\u300c\u9759\u6b62\u72b6\u614b\uff08quiescent state\uff09\u300d\u306b\u3042\u308a\u307e\u3059\u304c\u3001\u6210\u9577\u671f\u304c\u59cb\u307e\u308b\u3068\u6d3b\u6027\u5316\u3057\u3001\u3055\u307e\u3056\u307e\u306a\u7d30\u80de\u306b\u5909\u5316\uff08\u5206\u5316\uff09\u3057\u3066\u65b0\u3057\u3044\u9aea\u3092\u3064\u304f\u308a\u51fa\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>HFSCs\u306b\u306f\u3001\u5927\u304d\u304f3\u3064\u306e\u7279\u5fb4\u304c\u3042\u308a\u307e\u3059\u3002<br>1\u3064\u76ee\u306f\u3001\u9577\u671f\u9593\u306b\u308f\u305f\u3063\u3066\u9759\u6b62\u72b6\u614b\u3092\u4fdd\u3066\u308b\u3053\u3068\u3001<br>2\u3064\u76ee\u306f\u3001\u6d3b\u6027\u5316\u3059\u308b\u3068\u6025\u901f\u306b\u7d30\u80de\u3092\u5897\u3084\u305b\u308b\u3053\u3068\uff08\u5897\u6b96\u6027\u304c\u9ad8\u3044\u3053\u3068\uff09\u3001<br>\u305d\u3057\u30663\u3064\u76ee\u306f\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u8907\u6570\u306e\u7a2e\u985e\u306e\u7d30\u80de\u306b\u5206\u5316\u3067\u304d\u308b\u67d4\u8edf\u6027\uff08\u591a\u5206\u5316\u80fd\uff09\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6027\u8cea\u306e\u304a\u304b\u3052\u3067\u3001HFSCs\u306f\u6bdb\u306e\u518d\u751f\u3092\u9577\u304f\u652f\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/3318163_s.jpg\" alt=\"\" class=\"wp-image-7004\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/3318163_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/3318163_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/3318163_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-2-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5e74\u9f62\u3068\u3068\u3082\u306b\u5f31\u307e\u308b\u5e79\u7d30\u80de\u306e\u529b\u3068\u9aea\u306e\u5909\u5316<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"20\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/COL17A1_hgtIdeo_genome_407af_ec0c0-1024x20.png\" alt=\"COL17A1\" class=\"wp-image-7327\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/COL17A1_hgtIdeo_genome_407af_ec0c0-1024x20.png 1024w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/COL17A1_hgtIdeo_genome_407af_ec0c0-300x6.png 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/COL17A1_hgtIdeo_genome_407af_ec0c0-768x15.png 768w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/COL17A1_hgtIdeo_genome_407af_ec0c0-485x9.png 485w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/COL17A1_hgtIdeo_genome_407af_ec0c0.png 1382w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u5e74\u3092\u91cd\u306d\u308b\u3068\u3001\u6bdb\u5305\u5e79\u7d30\u80de\uff08hair follicle stem cells\uff1aHFSCs\uff09\u306e\u6570\u304c\u5c11\u306a\u304f\u306a\u3063\u305f\u308a\u3001\u50cd\u304d\u304c\u5f31\u307e\u3063\u305f\u308a\u3059\u308b\u3053\u3068\u3067\u3001\u9aea\u306b\u3055\u307e\u3056\u307e\u306a\u5909\u5316\u304c\u73fe\u308c\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u9aea\u304c\u7d30\u304f\u306a\u308b\u3001\u4f38\u3073\u308b\u30b9\u30d4\u30fc\u30c9\u304c\u9045\u304f\u306a\u308b\u3001\u6bdb\u5305\uff08hair follicle\uff09\u305d\u306e\u3082\u306e\u304c\u5c0f\u3055\u304f\u7e2e\u3093\u3067\u3057\u307e\u3046\u300c\u30df\u30cb\u30c1\u30e5\u30a2\u5316\uff08miniaturization\uff09\u300d\u3068\u3044\u3063\u305f\u73fe\u8c61\u304c\u898b\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u3046\u3057\u305f\u52a0\u9f62\u306b\u3068\u3082\u306a\u3046\u5909\u5316\u306b\u306f\u3001HFSCs\u3092\u6b63\u3057\u3044\u5834\u6240\u306b\u3068\u3069\u3081\u3066\u6a5f\u80fd\u3092\u4fdd\u3064\u5f79\u5272\u3092\u3082\u3064\u3042\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u304c\u300c\u30b3\u30e9\u30fc\u30b2\u30f317\u578b\u03b11\u9396\uff08collagen type XVII alpha 1 chain\uff1aCOL17A1\u3001\u5225\u540d\u30b3\u30e9\u30fc\u30b2\u30f3XVII\uff09\u300d\u3067\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-2-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<p>COL17A1\u306f\u3001HFSCs\u3092\u6bdb\u5305\u306e\u57fa\u5e95\u819c\uff08basement membrane\uff09\u306b\u3057\u3063\u304b\u308a\u3068\u56fa\u5b9a\u3059\u308b\u50cd\u304d\u3092\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3053\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5931\u308f\u308c\u308b\u3068\u3001HFSCs\u306f\u6bdb\u5305\u5185\u3067\u4f4d\u7f6e\u3092\u7dad\u6301\u3067\u304d\u306a\u304f\u306a\u308a\u3001\u65e9\u3044\u6bb5\u968e\u3067\u6a5f\u80fd\u3092\u5931\u3063\u3066\u3057\u307e\u3046\uff08\u67af\u6e07\u3059\u308b\uff09\u3053\u3068\u304c\u3001\u52d5\u7269\u5b9f\u9a13\u306b\u3088\u3063\u3066\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"884\" height=\"732\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/AF-Q9UMD9-F1.png\" alt=\"COL17A1_Collagen alpha-1(XVII) chain_secondarystructcolour\" class=\"wp-image-7322\" style=\"width:526px;height:auto\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/AF-Q9UMD9-F1.png 884w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/AF-Q9UMD9-F1-300x248.png 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/AF-Q9UMD9-F1-768x636.png 768w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/AF-Q9UMD9-F1-485x402.png 485w\" sizes=\"(max-width: 884px) 100vw, 884px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u80a5\u6e80\u304c\u539f\u56e0\u3067\u9aea\u304c\u629c\u3051\u308b\uff1f\u305d\u306e\u4ed5\u7d44\u307f\u306b\u8feb\u308b<\/h2>\n\n\n\n<p>\u80a5\u6e80\u306f\u3001\u7537\u6027\u578b\u3084\u5973\u6027\u578b\u306e\u8131\u6bdb\u75c7\uff08androgenic alopecia\uff1a<a href=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/about_natural-pro\/\">AGA<\/a>\uff09\u3068\u3044\u3063\u305f\u30db\u30eb\u30e2\u30f3\u306b\u95a2\u4fc2\u3059\u308b\u8131\u6bdb\u3068\u95a2\u9023\u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u306f\u3001\u30db\u30eb\u30e2\u30f3\u4ee5\u5916\u306b\u80a5\u6e80\u304c\u6bdb\u5305\uff08hair follicle\uff09\u5168\u4f53\u306b\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3059\u306e\u304b\u306f\u3001\u3042\u307e\u308a\u8a73\u3057\u304f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-2-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<p>\u305d\u3053\u3067\u7814\u7a76\u8005\u305f\u3061\u306f\u3001\u80a5\u6e80\u3068\u6bdb\u306e\u95a2\u4fc2\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u3001\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u5b9f\u9a13\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u9ad8\u9f62\u306e\u30aa\u30b9\u306e\u30de\u30a6\u30b9\uff08\u4eba\u9593\u3067\u8a00\u3048\u307060\u301c70\u6b73\u306b\u76f8\u5f53\uff09\u306b\u5bfe\u3057\u30011\u304b\u6708\u9593\u306b\u308f\u305f\u308a\u300c\u9ad8\u8102\u80aa\u98df\uff08high-fat diet\uff1aHFD\uff09\u300d\u307e\u305f\u306f\u300c\u6a19\u6e96\u98df\uff08normal diet\uff1aND\uff09\u300d\u3092\u4e0e\u3048\u3066\u3001\u305d\u306e\u5909\u5316\u3092\u89b3\u5bdf\u3057\u307e\u3057\u305f\u3002\u5b9f\u9a13\u3092\u59cb\u3081\u305f\u6642\u70b9\u3067\u306f\u3001\u3069\u3061\u3089\u306e\u30de\u30a6\u30b9\u306b\u3082\u76ee\u7acb\u3063\u305f\u8131\u6bdb\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"480\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/25347622_s-1.jpg\" alt=\"\u30ab\u30ed\u30ea\u30fc\u7206\u5f3e\" class=\"wp-image-7366\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/25347622_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/25347622_s-1-300x225.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/25347622_s-1-485x364.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3068\u3053\u308d\u304c\u3001\u308f\u305a\u304b1\u304b\u6708\u5f8c\u3001HFD\u3092\u4e0e\u3048\u3089\u308c\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u76ee\u306b\u898b\u3048\u308b\u307b\u3069\u5e83\u7bc4\u56f2\u306b\u6bdb\u304c\u629c\u3051\u3066\u3044\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001ND\u3092\u98df\u3079\u3066\u3044\u305f\u30de\u30a6\u30b9\u3067\u306f\u6bdb\u306e\u72b6\u614b\u306b\u5909\u5316\u306f\u306a\u304f\u3001\u6b63\u5e38\u306b\u4fdd\u305f\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u8840\u7cd6\u5024\u304c\u9ad8\u3044\u3053\u3068\u3067\u77e5\u3089\u308c\u308b\u7cd6\u5c3f\u75c5\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\uff08\u30ec\u30d7\u30c1\u30f3\u53d7\u5bb9\u4f53\u304c\u6a5f\u80fd\u3057\u306a\u3044db\/db\u30de\u30a6\u30b9\uff09\u3084\u3001\u9ad8\u7cd6\u5206\u306e\u98df\u4e8b\u3092\u4e0e\u3048\u3089\u308c\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u3053\u306e\u3088\u3046\u306a\u8131\u6bdb\u306f\u8d77\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u4eca\u56de\u898b\u3089\u308c\u305f\u8131\u6bdb\u306f\u3001\u8840\u7cd6\u5024\u306e\u9ad8\u3055\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u50cd\u304d\u306b\u554f\u984c\u304c\u3042\u308b\u304b\u3089\u3067\u306f\u306a\u304f\u3001\u80a5\u6e80\u306b\u3068\u3082\u306a\u3046\u300c\u8102\u8cea\u306e\u904e\u5270\uff08lipid overload\uff09\u300d\u304c\u4e3b\u306a\u539f\u56e0\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u5148\u5929\u7684\u306b\u300c\u30ec\u30d7\u30c1\u30f3\uff08leptin\uff09\u300d\u3068\u3044\u3046\u30db\u30eb\u30e2\u30f3\u304c\u4f5c\u3089\u308c\u305a\u3001\u751f\u307e\u308c\u3064\u304d\u592a\u308a\u3084\u3059\u3044ob\/ob\u30de\u30a6\u30b9\u3067\u3082\u3001\u540c\u69d8\u306b\u6bdb\u5305\u306e\u69cb\u9020\u304c\u52a3\u5316\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"435\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/Fatmouse-1.jpg\" alt=\"ob\/ob mouse\" class=\"wp-image-7363\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/Fatmouse-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/Fatmouse-1-300x204.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/Fatmouse-1-485x330.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-2-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u6bdb\u5305\u306e\u69cb\u9020\u5909\u5316\u3068\u5e79\u7d30\u80de\u306e\u7570\u5e38\u306a\u3075\u308b\u307e\u3044<\/h2>\n\n\n\n<p>\u9855\u5fae\u93e1\u3092\u4f7f\u3063\u3066\u9ad8\u8102\u80aa\u98df\uff08high-fat diet\uff1aHFD\uff09\u3092\u4e0e\u3048\u305f\u30de\u30a6\u30b9\u306e\u76ae\u819a\u7d44\u7e54\u3092\u8a73\u3057\u304f\u89b3\u5bdf\u3057\u305f\u3068\u3053\u308d\u3001\u6bdb\u5305\uff08hair follicle\uff09\u306b\u5927\u304d\u306a\u69cb\u9020\u7684\u306a\u7570\u5e38\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u7279\u306b\u3001\u6bdb\u5305\u5e79\u7d30\u80de\uff08hair follicle stem cells\uff1aHFSCs\uff09\u304c\u5b58\u5728\u3059\u308b\u300c\u30d0\u30eb\u30b8\u9818\u57df\uff08bulge region\uff09\u300d\u304c\u5931\u308f\u308c\u3066\u3044\u308b\u6bdb\u5305\u304c\u591a\u304f\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u901a\u5e38\u306f\u9aea\u3084\u76ae\u819a\u3092\u6cb9\u5206\u3067\u4fdd\u8b77\u3059\u308b\u305f\u3081\u306e\u300c\u76ae\u8102\u817a\uff08sebaceous gland\uff09\u300d\u304c\u3001\u7570\u5e38\u306b\u5927\u304d\u304f\u6b8b\u3063\u3066\u3044\u308b\u30b1\u30fc\u30b9\u304c\u591a\u304f\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u672c\u6765\u306a\u3089\u9aea\u306e\u518d\u751f\u306b\u4f7f\u308f\u308c\u308b\u3079\u304dHFSCs\u304c\u3001\u8aa4\u3063\u3066\u76ae\u8102\u817a\u306e\u7d30\u80de\u306b\u5909\u308f\u3063\u3066\u3057\u307e\u3063\u305f\u53ef\u80fd\u6027\u3001\u3064\u307e\u308a\u300c\u7570\u5e38\u5206\u5316\uff08aberrant differentiation\uff09\u300d\u304c\u8d77\u304d\u3066\u3044\u305f\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/24913103_s.jpg\" alt=\"\uff47\uff47\" class=\"wp-image-7369\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/24913103_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/24913103_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/24913103_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306a\u5909\u5316\u306f\u3001\u30aa\u30b9\u30fb\u30e1\u30b9\u4e21\u65b9\u306e\u30de\u30a6\u30b9\u306b\u5171\u901a\u3057\u3066\u898b\u3089\u308c\u3001\u4f53\u91cd\u304c\u91cd\u3044\u30de\u30a6\u30b9\u307b\u3069\u75c7\u72b6\u304c\u5f37\u304f\u306a\u308b\u3068\u3044\u3046\u95a2\u9023\u3082\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u30de\u30a6\u30b9\u306e\u6bdb\u306b\u306f3\u7a2e\u985e\u3042\u308a\u3001\u592a\u304f\u3066\u786c\u3044\u300c\u30ac\u30fc\u30c9\u30d8\u30a2\uff08guard hair\uff09\u300d\u3001\u4e2d\u304f\u3089\u3044\u306e\u592a\u3055\u306e\u300c\u30a2\u30a6\u30eb\u30fb\u30aa\u30a6\u30b7\u30fc\u30f3\u30d8\u30a2\uff08awl\/auchene hair\uff09\u300d\u3001\u305d\u3057\u3066\u6700\u3082\u7d30\u3044\u300c\u30b8\u30b0\u30b6\u30b0\u30d8\u30a2\uff08zigzag hair\uff09\u300d\u304c\u3042\u308a\u307e\u3059\u3002HFD\u3092\u4e0e\u3048\u3089\u308c\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u7279\u306b\u3053\u306e\u7d30\u3044\u30b8\u30b0\u30b6\u30b0\u30d8\u30a2\u304c\u629c\u3051\u3084\u3059\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u3053\u3046\u3057\u305f\u5c0f\u3055\u306a\u6bdb\u3092\u3064\u304f\u308bHFSCs\u306b\u3001\u3088\u308a\u5f37\u3044\u518d\u751f\u8ca0\u62c5\u304c\u304b\u304b\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-2-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<p>\u3055\u3089\u306b\u3001HFD\u30de\u30a6\u30b9\u3067\u306f\u3001\u76ae\u819a\u306e\u300c\u771f\u76ae\uff08dermis\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u4e2d\u9593\u5c64\u304c\u8584\u304f\u306a\u3063\u3066\u3044\u305f\u4e00\u65b9\u3067\u3001\u305d\u306e\u4e0b\u306b\u3042\u308b\u300c\u76ae\u4e0b\u7d44\u7e54\uff08subcutaneous tissue\uff09\u300d\u3001\u3064\u307e\u308a\u8102\u80aa\u5c64\u304c\u539a\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u52a0\u9f62\u306b\u3088\u3063\u3066\u8d77\u304d\u308b\u76ae\u819a\u306e\u5909\u5316\u3068\u4f3c\u305f\u50be\u5411\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001\u76ae\u819a\u306e\u4e00\u756a\u5916\u5074\u306b\u3042\u305f\u308b\u300c\u8868\u76ae\uff08epidermis\uff09\u300d\u306e\u539a\u3055\u306b\u306f\u5927\u304d\u306a\u5909\u5316\u304c\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u8868\u76ae\u5e79\u7d30\u80de\uff08epidermal stem cells\uff09\u306f\u3001HFSCs\u306b\u6bd4\u3079\u3066\u4ee3\u8b1d\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3057\u3066\u3088\u308a\u5f37\u3044\u6027\u8cea\u3092\u6301\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/2327343_s.jpg\" alt=\"\u30dd\u30c6\u30c1\u30bf\u30a4\u30e0\" class=\"wp-image-7372\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/2327343_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/2327343_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/2327343_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<h2 class=\"\" data-start=\"0\" data-end=\"27\">\u80a5\u6e80\u304c\u9aea\u306e\u751f\u3048\u5909\u308f\u308a\u306e\u30ea\u30ba\u30e0\u3068\u5e79\u7d30\u80de\u306e\u76ee\u899a\u3081\u308b\u30bf\u30a4\u30df\u30f3\u30b0\u3092\u4e71\u3059<\/h2>\n\n\n<p>\u80a5\u6e80\u304c\u6bdb\u5305\u5e79\u7d30\u80de\uff08hair follicle stem cells\uff1aHFSCs\uff09\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3068\u3057\u3066\u3001\u7279\u306b\u91cd\u8981\u306a\u767a\u898b\u306e\u4e00\u3064\u304c\u3001\u6bdb\u306e\u751f\u3048\u5909\u308f\u308a\u306e\u5468\u671f\u3001\u3044\u308f\u3086\u308b\u300c\u6bdb\u5468\u671f\uff08hair cycle\uff09\u300d\u306e\u4e71\u308c\u3067\u3059\u3002\u9ad8\u8102\u80aa\u98df\uff08high-fat diet\uff1aHFD\uff09\u3092\u4e0e\u3048\u3089\u308c\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u6bdb\u5468\u671f\u306b\u7570\u5e38\u304c\u8d77\u304d\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u5177\u4f53\u7684\u306b\u306f\u3001\u9aea\u306e\u6bdb\u304c\u6210\u9577\u3059\u308b\u300c\u6210\u9577\u671f\uff08anagen\uff09\u300d\u306e\u671f\u9593\u304c\u77ed\u304f\u306a\u308a\u3001\u901a\u5e38\u3088\u308a\u3082\u65e9\u304f\u300c\u4f11\u6b62\u671f\uff08telogen\uff09\u300d\u306b\u79fb\u884c\u3057\u3066\u3057\u307e\u3063\u3066\u3044\u305f\u306e\u3067\u3059\u3002\u3064\u307e\u308a\u3001\u9aea\u304c\u5341\u5206\u306b\u4f38\u3073\u308b\u524d\u306b\u3001\u6210\u9577\u304c\u6b62\u307e\u3063\u3066\u3057\u307e\u3046\u3068\u3044\u3046\u7570\u5e38\u306a\u30ea\u30ba\u30e0\u304c\u8d77\u3053\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/2327390_s.jpg\" alt=\"\u30dd\u30c6\u30c1\u30bf\u30a4\u30e0\uff12\" class=\"wp-image-7375\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/2327390_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/2327390_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/2327390_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u306e\u5909\u5316\u306f\u3001HFSCs\u304c\u6d3b\u6027\u5316\u3059\u308b\u30bf\u30a4\u30df\u30f3\u30b0\u3084\u3001\u6bdb\u5305\u5185\u306e\u300c\u5fae\u5c0f\u74b0\u5883\uff08microenvironment\uff09\u300d\u304c\u80a5\u6e80\u306b\u3088\u3063\u3066\u5909\u5316\u3057\u3066\u3057\u307e\u3063\u305f\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3068\u304f\u306b\u6ce8\u76ee\u3055\u308c\u305f\u306e\u306f\u3001\u300c\u771f\u76ae\uff08dermis\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u76ae\u819a\u306e\u4e2d\u9593\u5c64\u306b\u8102\u80aa\u304c\u5897\u3048\u308b\u300c\u76ae\u819a\u5185\u306e\u8102\u80aa\u84c4\u7a4d\uff08dermal adiposity\uff09\u300d\u304c\u95a2\u4fc2\u3057\u3066\u3044\u305f\u70b9\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u9a5a\u304f\u3079\u304d\u3053\u3068\u306b\u3001\u3053\u3046\u3057\u305f\u5927\u304d\u306a\u5909\u5316\u304c\u8d77\u304d\u3066\u3044\u305f\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u708e\u75c7\u7d30\u80de\u306e\u4fb5\u5165\uff08\u514d\u75ab\u7d30\u80de\u306e\u6d78\u6f64\uff09\u3001\u6bdb\u7d30\u8840\u7ba1\u306e\u6e1b\u5c11\u3001\u795e\u7d4c\u306e\u640d\u50b7\u3068\u3044\u3063\u305f\u901a\u5e38\u307f\u3089\u308c\u308b\u7d44\u7e54\u306e\u50b7\u307f\u306f\u78ba\u8a8d\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3064\u307e\u308a\u3001\u80a5\u6e80\u306e\u5f71\u97ff\u306f\u3001\u708e\u75c7\u3084\u8840\u6d41\u306e\u60aa\u5316\u3068\u3044\u3063\u305f\u5468\u8fba\u74b0\u5883\u306e\u5909\u5316\u306b\u3088\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001HFSCs\u305d\u306e\u3082\u306e\u304c\u4e3b\u306a\u6a19\u7684\u3068\u306a\u3063\u3066\u3044\u305f\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/30330989_s-1.jpg\" alt=\"\u304a\u306a\u304b\" class=\"wp-image-7378\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/30330989_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/30330989_s-1-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/30330989_s-1-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<h2 class=\"\" data-start=\"423\" data-end=\"443\">\u5e79\u7d30\u80de\u306f\u306a\u305c\u6bdb\u3092\u3064\u304f\u3089\u305a\u3001\u76ae\u819a\u306b\u5909\u308f\u3063\u3066\u3057\u307e\u3046\u306e\u304b\uff1f<\/h2>\n\n\n<p>\u5e79\u7d30\u80de\uff08stem cells\uff09\u304c\u80a5\u6e80\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3066\u3069\u306e\u3088\u3046\u306b\u632f\u308b\u821e\u3046\u306e\u304b\u3092\u8a73\u3057\u304f\u8abf\u3079\u308b\u305f\u3081\u306b\u3001\u7814\u7a76\u8005\u305f\u3061\u306f\u7279\u6b8a\u306a\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3092\u4f7f\u3063\u3066\u5b9f\u9a13\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u30de\u30a6\u30b9\u3067\u306f\u3001\u6bdb\u5305\u5e79\u7d30\u80de\uff08hair follicle stem cells\uff1aHFSCs\uff09\u3068\u305d\u306e\u5b50\u5b6b\u306e\u7d30\u80de\u306b\u86cd\u5149\u30e9\u30d9\u30eb\u3092\u3064\u3051\u3066\u3001\u4f53\u5185\u3067\u306e\u52d5\u304d\u3092\u8ffd\u8de1\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u901a\u5e38\u306e\u98df\u4e8b\u3092\u4e0e\u3048\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001HFSCs\u306f\u6bdb\u5305\u306e\u300c\u30d0\u30eb\u30b8\u9818\u57df\uff08bulge region\uff09\u300d\u306b\u3068\u3069\u307e\u308a\u3001\u9aea\u304c\u4f38\u3073\u308b\u300c\u6210\u9577\u671f\uff08anagen\uff09\u300d\u306b\u306a\u308b\u3068\u3001\u6bdb\u306e\u6839\u5143\u65b9\u5411\uff08\u4e0b\u5411\u304d\uff09\u306b\u5206\u5316\u3057\u3001\u65b0\u3057\u3044\u9aea\u3092\u3064\u304f\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3068\u3053\u308d\u304c\u3001\u9ad8\u8102\u80aa\u98df\uff08high-fat diet\uff1aHFD\uff09\u30923\u304b\u6708\u9593\u4e0e\u3048\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u30d0\u30eb\u30b8\u9818\u57df\u304b\u3089HFSCs\u304c\u5931\u308f\u308c\u3001\u4ee3\u308f\u308a\u306b\u305d\u306e\u5b50\u5b6b\u7d30\u80de\u304c\u6bdb\u5305\u306e\u4e0a\u90e8\u3001\u305f\u3068\u3048\u3070\u76ae\u8102\u817a\uff08sebaceous gland\uff09\u3084\u63a5\u5408\u90e8\u9818\u57df\uff08junctional zone\uff09\u3001\u6bdb\u5305\u306e\u5916\u5074\u306b\u3042\u308b\u8868\u76ae\uff08epidermis\uff09\u3078\u3068\u79fb\u52d5\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u8001\u5316\u3084\u76ae\u819a\u306e\u30c0\u30e1\u30fc\u30b8\u304c\u3042\u308b\u5834\u5408\u306b\u3088\u304f\u898b\u3089\u308c\u308b\u73fe\u8c61\u3068\u4f3c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/3861612_s.jpg\" alt=\"\u304e\u3085\u3046\u3046\" class=\"wp-image-7402\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/3861612_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/3861612_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/3861612_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u672c\u6765\u306f\u9aea\u306e\u518d\u751f\u3092\u62c5\u3046\u306f\u305a\u306e\u5e79\u7d30\u80de\u304c\u3001\u5168\u304f\u5225\u306e\u7a2e\u985e\u306e\u7d30\u80de\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u73fe\u8c61\u306f\u3001\u300c\u5e79\u7d30\u80de\u306e\u904b\u547d\u8ee2\u63db\uff08fate-switching\uff09\u300d\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u3001HFSCs\u304c\u9aea\u3092\u3064\u304f\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u76ae\u819a\u306e\u8868\u9762\u3092\u69cb\u6210\u3059\u308b\u300c\u8868\u76ae\u7d30\u80de\uff08epidermal cells\uff09\u300d\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u5b9f\u969b\u306b\u3001\u3053\u306e\u904b\u547d\u8ee2\u63db\u304c\u8d77\u304d\u305f\u7d30\u80de\u3067\u306f\u3001\u76ae\u819a\u306b\u7279\u6709\u306e\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u300c\u30b1\u30e9\u30c1\u30f31\uff08keratin 1\uff1aK1\uff09\u300d\u306a\u3069\u304c\u767a\u73fe\u3057\u3066\u304a\u308a\u3001\u672c\u6765\u306e\u6bdb\u3092\u69cb\u6210\u3059\u308b\u6027\u8cea\u3092\u5931\u3044\u3001\u76ae\u819a\u3068\u3057\u3066\u306e\u7279\u5fb4\u3092\u6301\u3064\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-2-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<p>\u3055\u3089\u306b\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u6bdb\u3092\u5f15\u304d\u629c\u304f\u3068\u3044\u3063\u305f\u7269\u7406\u7684\u307e\u305f\u306f\u5316\u5b66\u7684\u306a\u523a\u6fc0\uff08\u8131\u6bdb\u51e6\u7406\u3001depilation\uff09\u3092\u52a0\u3048\u308b\u3060\u3051\u3067\u3082\u3001HFD\u30de\u30a6\u30b9\u3067\u306f\u540c\u3058\u3088\u3046\u306b\u904b\u547d\u8ee2\u63db\u304c\u8d77\u304d\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u3002\u672c\u6765\u3067\u3042\u308c\u3070\u3001\u3053\u3046\u3057\u305f\u523a\u6fc0\u306f\u5e79\u7d30\u80de\u3092\u76ee\u899a\u3081\u3055\u305b\u3001\u9aea\u306e\u518d\u751f\u3092\u4fc3\u3059\u306f\u305a\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u80a5\u6e80\u306b\u3088\u308b\u4ee3\u8b1d\u30b9\u30c8\u30ec\u30b9\u304c\u52a0\u308f\u308b\u3053\u3068\u3067\u3001\u9006\u306b\u5e79\u7d30\u80de\u306e\u306f\u305f\u3089\u304d\u3092\u4e71\u3057\u3001\u672c\u6765\u3068\u306f\u7570\u306a\u308b\u7d30\u80de\u3078\u3068\u5909\u308f\u3063\u3066\u3057\u307e\u3046\u3002\u671b\u307e\u3057\u304f\u306a\u3044\u9006\u52b9\u679c\u304c\u8d77\u3053\u3063\u3066\u3044\u305f\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/30453822_s.jpg\" alt=\"\u91ce\u83dc\u306f\u3044\u3044\u3067\u3059\" class=\"wp-image-7381\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/30453822_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/30453822_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/30453822_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<h2 class=\"\" data-start=\"1067\" data-end=\"1089\">\u306a\u305c\u5e79\u7d30\u80de\u306f\u8aa4\u3063\u3066\u76ae\u819a\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u306e\u304b\uff1f \u305d\u306e\u5206\u5b50\u30ec\u30d9\u30eb\u306e\u4ed5\u7d44\u307f\u3068\u306f<\/h2>\n\n\n<p>\u5e79\u7d30\u80de\uff08stem cells\uff09\u304c\u672c\u6765\u306e\u5f79\u5272\u3092\u96e2\u308c\u3001\u9aea\u3092\u3064\u304f\u3089\u305a\u306b\u76ae\u819a\u306e\u7d30\u80de\u3078\u3068\u5909\u5316\u3057\u3066\u3057\u307e\u3046\u300c\u904b\u547d\u8ee2\u63db\uff08fate-switching\uff09\u300d\u306f\u3001\u306a\u305c\u8d77\u304d\u305f\u306e\u3067\u3057\u3087\u3046\u304b\uff1f \u3053\u306e\u7591\u554f\u306b\u7b54\u3048\u308b\u305f\u3081\u306b\u3001\u7814\u7a76\u8005\u305f\u3061\u306f2\u3064\u306e\u5206\u5b50\u89e3\u6790\u6280\u8853\u3092\u7528\u3044\u3066\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u8a73\u3057\u304f\u8abf\u3079\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>1\u3064\u76ee\u306f\u300cRNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\uff08RNA sequencing\uff09\u300d\u3068\u3044\u3046\u624b\u6cd5\u3067\u3001\u7d30\u80de\u306e\u4e2d\u3067\u5b9f\u969b\u306b\u3069\u306e\u907a\u4f1d\u5b50\u304c\u50cd\u3044\u3066\u3044\u308b\u306e\u304b\u3092\u8aad\u307f\u53d6\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u30022\u3064\u76ee\u306f\u300cATAC-seq\uff08Assay for Transposase-Accessible Chromatin using sequencing\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u65b9\u6cd5\u3067\u3001DNA\u304c\u3069\u306e\u7a0b\u5ea6\u958b\u304b\u308c\u3066\u3044\u308b\u304b\u3001\u3064\u307e\u308a\u3001\u3069\u306e\u907a\u4f1d\u5b50\u304c\u4f7f\u3044\u3084\u3059\u3044\u72b6\u614b\u306b\u306a\u3063\u3066\u3044\u308b\u304b\u3092\u89e3\u6790\u3059\u308b\u6280\u8853\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/31969926_s.jpg\" alt=\"\u7814\u7a76\u8005\" class=\"wp-image-7384\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/31969926_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/31969926_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/31969926_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6280\u8853\u3092\u7528\u3044\u3066\u3001\u52a0\u9f62\u306b\u3088\u3063\u3066\u81ea\u7136\u306b\u8001\u5316\u3057\u305f\u30de\u30a6\u30b9\u3068\u3001\u9ad8\u8102\u80aa\u98df\uff08high-fat diet\uff1aHFD\uff09\u3092\u4e0e\u3048\u305f\u30de\u30a6\u30b9\u3092\u6bd4\u8f03\u3057\u305f\u3068\u3053\u308d\u3001\u8208\u5473\u6df1\u3044\u9055\u3044\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u52a0\u9f62\u306b\u3088\u308b\u8001\u5316\u3067\u306f\u3001\u52a0\u9f62\u306e\u30de\u30fc\u30ab\u30fc\u3068\u3055\u308c\u308b\u300cCol17a1\uff08collagen type XVII alpha 1 chain\uff09\u300d\u306e\u767a\u73fe\u304c\u5927\u304d\u304f\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001HFD\u30de\u30a6\u30b9\u306e\u6bdb\u5305\u5e79\u7d30\u80de\uff08hair follicle stem cells\uff1aHFSCs\uff09\u3067\u306f\u3001\u52a0\u9f62\u3067\u306f\u898b\u3089\u308c\u306a\u3044\u30bf\u30a4\u30d7\u306e\u5909\u5316\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u308c\u306f\u300c\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5909\u5316\uff08epigenetic changes\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u3082\u306e\u3067\u3001DNA\u306e\u914d\u5217\u305d\u306e\u3082\u306e\u306b\u306f\u5909\u5316\u304c\u306a\u3044\u3082\u306e\u306e\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306e\u3055\u308c\u65b9\u304c\u5909\u308f\u3063\u3066\u3057\u307e\u3063\u3066\u3044\u305f\u306e\u3067\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-2-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<p>\u3068\u304f\u306b\u6ce8\u76ee\u3055\u308c\u305f\u306e\u306f\u3001HFSCs\u304c\u9759\u6b62\u72b6\u614b\uff08quiescence\uff09\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u306a\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308b\u300cNFATC1\uff08nuclear factor of activated T-cells, cytoplasmic 1\uff09\u300d\u3068\u300cMED1\uff08mediator complex subunit 1\uff09\u300d\u304c\u4f5c\u7528\u3059\u308bDNA\u9818\u57df\u306e\u69cb\u9020\u304c\u9589\u3058\u6c17\u5473\u306b\u306a\u3063\u3066\u3044\u305f\u3053\u3068\u3067\u3059\u3002\u3053\u308c\u306f\u3001\u5e79\u7d30\u80de\u304c\u672c\u6765\u306e\u3088\u3046\u306b\u201c\u7720\u3063\u3066\u3044\u308b\u201d\u3053\u3068\u304c\u3067\u304d\u305a\u3001\u65e9\u304f\u76ee\u899a\u3081\u3059\u304e\u3066\u3057\u307e\u3046\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5e79\u7d30\u80de\u304c\u5fc5\u8981\u4ee5\u4e0a\u306b\u65e9\u304f\u6d3b\u6027\u5316\u3055\u308c\u308b\u3068\u3001\u305d\u306e\u5206\u3060\u3051\u50cd\u304d\u3059\u304e\u3066\u65e9\u304f\u6d88\u8017\u3057\u3001\u9aea\u306e\u518d\u751f\u80fd\u529b\u304c\u9577\u304f\u6301\u305f\u306a\u304f\u306a\u308b\u3002\u3053\u306e\u30ea\u30b9\u30af\u304c\u80a5\u6e80\u306b\u3088\u3063\u3066\u9ad8\u307e\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/22830698_s.jpg\" alt=\"\u904b\u52d5\" class=\"wp-image-7387\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/22830698_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/22830698_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/22830698_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<h2 class=\"\" data-start=\"1708\" data-end=\"1732\">\u5e79\u7d30\u80de\u306e\u50cd\u304d\u3092\u6b62\u3081\u308b\u539f\u56e0\u306f\uff1f\u91cd\u8981\u306a\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u6291\u5236\u3068\u306f<\/h2>\n\n\n<p>\u80a5\u6e80\u304c\u6bdb\u5305\u5e79\u7d30\u80de\uff08hair follicle stem cells\uff1aHFSCs\uff09\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3068\u3057\u3066\u3001\u3082\u3046\u4e00\u3064\u6ce8\u76ee\u3059\u3079\u304d\u70b9\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u308c\u306f\u3001\u5e79\u7d30\u80de\u306e\u6a5f\u80fd\u3092\u652f\u3048\u308b\u300c\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\uff08signaling pathways\uff09\u300d\u304c\u3001\u9ad8\u8102\u80aa\u98df\uff08high-fat diet\uff1aHFD\uff09\u3092\u4e0e\u3048\u3089\u308c\u305f\u30de\u30a6\u30b9\u3067\u306f\u5927\u304d\u304f\u6291\u5236\u3055\u308c\u3066\u3044\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u5f71\u97ff\u3092\u53d7\u3051\u3066\u3044\u305f\u306e\u306f\u3001\u300cMAPK\u7d4c\u8def\uff08mitogen-activated protein kinase pathway\uff09\u300d\u3068\u300cSHH\u7d4c\u8def\uff08Sonic Hedgehog pathway\uff09\u300d\u3068\u3044\u30462\u3064\u306e\u91cd\u8981\u306a\u7d4c\u8def\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3046\u3061\u3001SHH\u7d4c\u8def\uff08Sonic Hedgehog pathway\uff09\u306f\u3001\u80ce\u5150\u306e\u767a\u751f\u3084\u6210\u4f53\u306e\u7d44\u7e54\u518d\u751f\u306b\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u6bdb\u5305\uff08hair follicle\uff09\u306b\u304a\u3044\u3066\u306f\u300c\u6210\u9577\u671f\uff08anagen\uff09\u300d\u3078\u306e\u79fb\u884c\u3092\u8a98\u5c0e\u3059\u308b\u9375\u3068\u306a\u308b\u7d4c\u8def\u3067\u3059\u3002\u3053\u306e\u7d4c\u8def\u304c\u6b63\u5e38\u306b\u50cd\u304b\u306a\u3044\u3068\u3001HFSCs\u306f\u6d3b\u6027\u5316\u3055\u308c\u305a\u3001\u9aea\u304c\u4f38\u3073\u308b\u305f\u3081\u306e\u6e96\u5099\u304c\u6574\u308f\u306a\u304f\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"640\" height=\"470\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/29041537_s.jpg\" alt=\"SHH\" class=\"wp-image-7390\" style=\"width:460px;height:auto\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/29041537_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/29041537_s-300x220.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/29041537_s-485x356.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u5b9f\u969b\u3001SHH\u7d4c\u8def\u306e\u50cd\u304d\u3092\u9078\u629e\u7684\u306b\u906e\u65ad\u3067\u304d\u308b\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3092\u4f7f\u3063\u305f\u5b9f\u9a13\u3067\u3082\u3001\u305d\u306e\u91cd\u8981\u6027\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u7814\u7a76\u3067\u306f\u3001\u305f\u3063\u305f1\u9031\u9593SHH\u306e\u6a5f\u80fd\u3092\u6b62\u3081\u305f\u3060\u3051\u3067\u3001HFSCs\u304c\u6bdb\u5305\u304b\u3089\u5931\u308f\u308c\u3001\u6bdb\u5305\u81ea\u4f53\u304c\u5c0f\u3055\u304f\u306a\u3063\u3066\uff08\u30df\u30cb\u30c1\u30e5\u30a2\u5316\u3057\uff09\u3001\u76ee\u306b\u898b\u3048\u308b\u8131\u6bdb\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u7d50\u679c\u306f\u3001HFD\u3092\u4e0e\u3048\u3089\u308c\u305f\u30de\u30a6\u30b9\u3067\u89b3\u5bdf\u3055\u308c\u305f\u5909\u5316\u3068\u307b\u307c\u540c\u3058\u3067\u3042\u308a\u3001\u80a5\u6e80\u306b\u3088\u3063\u3066SHH\u7d4c\u8def\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u304c\u3001\u5e79\u7d30\u80de\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3068\u8131\u6bdb\u306e\u76f4\u63a5\u7684\u306a\u539f\u56e0\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"481\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/4208797_s.jpg\" alt=\"\u304e\u3085\u30fc\" class=\"wp-image-7393\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/4208797_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/4208797_s-300x225.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/4208797_s-485x365.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-2-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u306a\u305cSHH\u7d4c\u8def\u306f\u80a5\u6e80\u3067\u6b62\u307e\u3063\u3066\u3057\u307e\u3046\u306e\u304b\uff1f \u708e\u75c7\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u95a2\u4fc2<\/h2>\n\n\n\n<p>\u305d\u308c\u3067\u306f\u3001\u306a\u305c\u9ad8\u8102\u80aa\u98df\uff08high-fat diet\uff1aHFD\uff09\u3092\u6442\u308b\u3053\u3068\u3067\u3001Sonic Hedgehog\uff08SHH\uff09\u7d4c\u8def\u306e\u50cd\u304d\u304c\u6291\u3048\u3089\u308c\u3066\u3057\u307e\u3046\u306e\u3067\u3057\u3087\u3046\u304b\uff1f \u305d\u306e\u7406\u7531\u3092\u63a2\u308b\u305f\u3081\u306b\u3001\u7814\u7a76\u8005\u305f\u3061\u306fSHH\u7d4c\u8def\u306e\u300c\u4e0a\u6d41\u300d\u306b\u3042\u305f\u308b\u708e\u75c7\u30b7\u30b0\u30ca\u30eb\u306b\u6ce8\u76ee\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u6ce8\u76ee\u3055\u308c\u305f\u306e\u304c\u3001\u300c\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f31\u53d7\u5bb9\u4f53\uff08interleukin-1 receptor\uff1aIL-1R\uff09\u300d\u3092\u4ecb\u3059\u308b\u7d4c\u8def\u3067\u3059\u3002\u3053\u306e\u7d4c\u8def\u306f\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u4e00\u7a2e\u3067\u3042\u308b\u300c\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f31\u30d9\u30fc\u30bf\uff08interleukin-1 beta\uff1aIL-1\u03b2\uff09\u300d\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u307e\u3059\u3002IL-1\u03b2\u306f\u3001\u7d30\u80de\u306e\u4e2d\u306b\u3042\u308b\u8ee2\u5199\u56e0\u5b50\u300cNF-\u03baB\uff08nuclear factor kappa-light-chain-enhancer of activated B cells\uff09\u300d\u3092\u523a\u6fc0\u3057\u3001\u708e\u75c7\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3059\u50cd\u304d\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/31899951_s.jpg\" alt=\"\u4e21\u624b\u3067\u98df\u3079\u307e\u3059\" class=\"wp-image-7396\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/31899951_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/31899951_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/31899951_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>HFD\u3092\u4e0e\u3048\u3089\u308c\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u76ae\u819a\u306e\u8868\u76ae\u3084\u6bdb\u5305\u5e79\u7d30\u80de\uff08hair follicle stem cells\uff1aHFSCs\uff09\u3067IL-1\u03b2\u306e\u767a\u73fe\u304c\u9ad8\u307e\u3063\u3066\u304a\u308a\u3001\u540c\u6642\u306b\u300c8-\u30aa\u30ad\u30bd\u30b0\u30a2\u30cb\u30f3\uff088-oxoguanine\uff09\u300d\u3068\u3044\u3046\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u6307\u6a19\u3082\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u6d3b\u6027\u9178\u7d20\u7a2e\uff08reactive oxygen species\uff1aROS\uff09\u306b\u3088\u3063\u3066DNA\u304c\u50b7\u3064\u3044\u305f\u75d5\u8de1\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001HFSCs\u306e\u5185\u90e8\u306b\u306f\u300c\u8102\u80aa\u6ef4\uff08lipid droplets\uff09\u300d\u304c\u84c4\u7a4d\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u306f\u8102\u80aa\u306e\u904e\u5270\u306b\u3088\u308b\u7d30\u80de\u969c\u5bb3\u3001\u3044\u308f\u3086\u308b\u300c\u30ea\u30dd\u30c8\u30ad\u30b7\u30b7\u30c6\u30a3\uff08lipotoxicity\uff09\u300d\u304c\u8d77\u304d\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u708e\u75c7\u3084\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304cSHH\u7d4c\u8def\u306b\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<br>\u7814\u7a76\u8005\u305f\u3061\u306f\u3001\u76ae\u819a\u306e\u89d2\u5316\u7d30\u80de\uff08keratinocyte\uff09\u3092\u7528\u3044\u305f\u57f9\u990a\u5b9f\u9a13\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d30\u80de\u306bIL-1\u03b2\u3001\u3082\u3046\u4e00\u3064\u306e\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308bIL-6\u3001\u305d\u3057\u3066\u6d3b\u6027\u9178\u7d20\uff08ROS\uff09\u3092\u52a0\u3048\u308b\u3068\u3001SHH\u7d4c\u8def\u306e\u6a19\u7684\u907a\u4f1d\u5b50\u3067\u3042\u308bGli1\u3001Gli2\u3001Ptch1\u306e\u767a\u73fe\u304c\u5927\u304d\u304f\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-2-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u4e00\u7a2e\u3067\u3042\u308bTNF\uff08\u816b\u760d\u58ca\u6b7b\u56e0\u5b50\u3001tumor necrosis factor\uff09\u3092\u52a0\u3048\u3066\u3082\u3001\u3053\u306e\u3088\u3046\u306a\u6291\u5236\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3064\u307e\u308a\u3001\u708e\u75c7\u304c\u8d77\u304d\u308c\u3070\u4f55\u3067\u3082SHH\u7d4c\u8def\u3092\u6b62\u3081\u308b\u3068\u3044\u3046\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u7279\u5b9a\u306e\u56e0\u5b50\uff08IL-1\u03b2\u3084IL-6\u3001ROS\u306a\u3069\uff09\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u30de\u30a6\u30b9\u306e\u76ae\u819a\u306bIL-1\u03b2\u3092\u76f4\u63a5\u6ce8\u5c04\u3059\u308b\u3068\u3044\u3046\u5b9f\u9a13\u3082\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001SHH\u7d4c\u8def\u306e\u6d3b\u52d5\u304c\u5b9f\u969b\u306b\u6291\u3048\u3089\u308c\u307e\u3057\u305f\u3002\u305f\u3060\u3057\u3001\u82e5\u3044\u30de\u30a6\u30b9\u306e\u76ae\u819a\u3067\u306f\u708e\u75c7\u53cd\u5fdc\u306e\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u300cCOX2\uff08cyclooxygenase-2\uff09\u300d\u306b\u306f\u5927\u304d\u306a\u5909\u5316\u304c\u898b\u3089\u308c\u305a\u3001\u82e5\u3044\u76ae\u819a\u306b\u306f\u4e00\u6642\u7684\u306a\u708e\u75c7\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u3042\u308b\u7a0b\u5ea6\u306e\u8010\u6027\u304c\u3042\u308b\u3053\u3068\u3082\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/31235008_s.jpg\" alt=\"\u98df\u3079\u307e\u3059\" class=\"wp-image-7399\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/31235008_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/31235008_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/31235008_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-2-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u708e\u75c7\u304c\u305a\u3063\u3068\u7d9a\u304f\u3068\u3001\u9aea\u306f\u3069\u3046\u306a\u308b\uff1f IL-1\u30b7\u30b0\u30ca\u30eb\u306e\u6162\u6027\u6d3b\u6027\u5316\u3068\u8131\u6bdb\u306e\u95a2\u4fc2<\/h2>\n\n\n\n<p>\u708e\u75c7\u304c\u305a\u3063\u3068\u7d9a\u304f\u3068\u3001\u6bdb\u5305\u5e79\u7d30\u80de\uff08hair follicle stem cells\uff1aHFSCs\uff09\u306f\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u53d7\u3051\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f \u3053\u306e\u7591\u554f\u306b\u7b54\u3048\u308b\u305f\u3081\u306b\u3001\u7814\u7a76\u8005\u305f\u3061\u306f\u300cIL-1\u53d7\u5bb9\u4f53\u62ee\u6297\u56e0\u5b50\uff08interleukin-1 receptor antagonist\uff1aIL-1Ra\uff09\u300d\u3068\u3044\u3046\u3001\u708e\u75c7\u3092\u6291\u3048\u308b\u5206\u5b50\u304c\u50cd\u304b\u306a\u3044\u3088\u3046\u306b\u907a\u4f1d\u5b50\u64cd\u4f5c\u3055\u308c\u305f\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u5b9f\u9a13\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u30de\u30a6\u30b9\u306f\u300cIL-1Ra\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\uff08IL-1Ra knockout mice\uff09\u300d\u3068\u547c\u3070\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-2-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<p>\u3053\u306e\u30de\u30a6\u30b9\u3067\u306f\u3001\u4f53\u5185\u306eIL-1\u7d4c\u8def\uff08interleukin-1 signaling pathway\uff09\u304c\u5e38\u306b\u6d3b\u6027\u5316\u3055\u308c\u305f\u72b6\u614b\u306b\u3042\u308a\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u7279\u5225\u306a\u5916\u7684\u708e\u75c7\u3084\u611f\u67d3\u75c7\u304c\u306a\u304f\u3066\u3082\u3001\u4f53\u306e\u4e2d\u3067\u306f\u6162\u6027\u7684\u306a\u708e\u75c7\u306e\u30b7\u30b0\u30ca\u30eb\u304c\u51fa\u7d9a\u3051\u3066\u3044\u308b\u72b6\u614b\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u306e\u7d50\u679c\u3001IL-1Ra\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3067\u306f\u3001\u90e8\u5206\u7684\u306a\u8131\u6bdb\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u5168\u8eab\u306b\u5f37\u3044\u708e\u75c7\u304c\u8d77\u304d\u3066\u3044\u306a\u304f\u3066\u3082\u3001IL-1\u306e\u30b7\u30b0\u30ca\u30eb\u304c\u9577\u671f\u9593\u306b\u308f\u305f\u3063\u3066\u7d99\u7d9a\u7684\u306b\u6d3b\u6027\u5316\u3055\u308c\u308b\u3053\u3068\u3067\u3001HFSCs\u306e\u50cd\u304d\u304c\u59a8\u3052\u3089\u308c\u3001\u9aea\u306e\u518d\u751f\u304c\u3046\u307e\u304f\u3044\u304b\u306a\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/24811538_s.jpg\" alt=\"\u68ee\u3067\u3088\u304f\u306a\u3044\uff1f\" class=\"wp-image-7248\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/24811538_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/24811538_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/24811538_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">IL-1\u03b2\u306f\u3069\u3053\u304b\u3089\u6765\u308b\u306e\u304b\uff1f \u5b9f\u306f\u514d\u75ab\u7d30\u80de\u3067\u306f\u306a\u304b\u3063\u305f<\/h2>\n\n\n\n<p>\u4e00\u822c\u7684\u306b\u3001IL-1\u03b2\uff08interleukin-1 beta\uff09\u306e\u3088\u3046\u306a\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08inflammatory cytokine\uff09\u306f\u3001T\u30ea\u30f3\u30d1\u7403\u306a\u3069\u306e\u514d\u75ab\u7d30\u80de\uff08immune cells\uff09\u306b\u3088\u3063\u3066\u5206\u6ccc\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u9ad8\u8102\u80aa\u98df\uff08high-fat diet\uff1aHFD\uff09\u3092\u4e0e\u3048\u3089\u308c\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u4e8b\u60c5\u304c\u5c11\u3057\u7570\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u4eca\u56de\u306e\u7814\u7a76\u306b\u3088\u308a\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u306e\u306f\u3001IL-1\u03b2\u306e\u4e3b\u306a\u767a\u751f\u6e90\u304c\u3001\u6bdb\u5305\u5e79\u7d30\u80de\uff08hair follicle stem cells\uff1aHFSCs\uff09\u81ea\u8eab\u3001\u3042\u308b\u3044\u306f\u305d\u306e\u5468\u56f2\u306b\u3042\u308b\u76ae\u819a\u306e\u7d30\u80de\uff08skin cells\uff09\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-2-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<p>\u3064\u307e\u308a\u3001\u514d\u75ab\u7d30\u80de\u304c\u5916\u304b\u3089\u708e\u75c7\u3092\u8d77\u3053\u3057\u3066\u3044\u305f\u306e\u3067\u306f\u306a\u304f\u3001\u76ae\u819a\u306e\u4e2d\u306e\u7d30\u80de\u304c\u81ea\u3089\u306e\u300c\u4ee3\u8b1d\u30b9\u30c8\u30ec\u30b9\uff08metabolic stress\uff09\u300d\u306b\u3088\u3063\u3066IL-1\u03b2\u3092\u751f\u307f\u51fa\u3057\u3001\u76ae\u819a\u306e\u5185\u90e8\u3067\u708e\u75c7\u3092\u81ea\u5df1\u5897\u5e45\u3055\u305b\u308b\u300c\u30eb\u30fc\u30d7\u300d\u304c\u3067\u304d\u3066\u3044\u305f\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u767a\u898b\u306f\u3001\u708e\u75c7\u304c\u5fc5\u305a\u3057\u3082\u5916\u7684\u306a\u514d\u75ab\u53cd\u5fdc\u304b\u3089\u59cb\u307e\u308b\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u80a5\u6e80\u306b\u3088\u308a\u7d30\u80de\u81ea\u8eab\u304c\u30b9\u30c8\u30ec\u30b9\u3092\u611f\u3058\u305f\u7d50\u679c\u3068\u3057\u3066\u3001\u76ae\u819a\u5185\u3067\u6162\u6027\u7684\u306a\u708e\u75c7\u72b6\u614b\u304c\u4f5c\u308a\u51fa\u3055\u308c\u3066\u3057\u307e\u3046\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"480\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/3471269_s.jpg\" alt=\"\u3042\u30fc\" class=\"wp-image-7360\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/3471269_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/3471269_s-300x225.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/3471269_s-485x364.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u708e\u75c7\u3088\u308a\u5148\u306b\u8d77\u3053\u308b\u306e\u306f\uff1f \u5e79\u7d30\u80de\u3092\u63fa\u308b\u304c\u3059\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5f71\u97ff\u3068\u306f<\/h2>\n\n\n\n<p>\u9ad8\u8102\u80aa\u98df\uff08high-fat diet\uff1aHFD\uff09\u3092\u59cb\u3081\u3066\u304b\u3089\u308f\u305a\u304b4\u65e5\u9593\u3067\u3001\u6bdb\u5305\u5e79\u7d30\u80de\uff08hair follicle stem cells\uff1aHFSCs\uff09\u306b\u3069\u306e\u3088\u3046\u306a\u5909\u5316\u304c\u8d77\u304d\u308b\u306e\u304b\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\u3001\u975e\u5e38\u306b\u65e9\u3044\u6bb5\u968e\u3067\u300c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u7531\u6765\u306e\u6d3b\u6027\u9178\u7d20\uff08mitochondrial reactive oxygen species\uff1amitochondrial ROS\uff09\u300d\u306e\u5897\u52a0\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001\u3053\u306e\u6642\u70b9\u3067\u306f\u307e\u3060\u3001\u300cSonic Hedgehog\uff08SHH\uff09\u7d4c\u8def\u300d\u3084\u300cNF-\u03baB\uff08nuclear factor kappa-light-chain-enhancer of activated B cells\uff09\u7d4c\u8def\u300d\u3001\u300c\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f31\u53d7\u5bb9\u4f53\u7d4c\u8def\uff08interleukin-1 receptor\uff1aIL-1R pathway\uff09\u300d\u306a\u3069\u3001\u708e\u75c7\u306b\u95a2\u308f\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306b\u306f\u5927\u304d\u306a\u5909\u5316\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-2-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<p>\u3053\u306e\u7d50\u679c\u304b\u3089\u3001HFD\u306b\u3088\u308b\u5f71\u97ff\u306f\u307e\u305a\u9178\u5316\u30b9\u30c8\u30ec\u30b9\uff08oxidative stress\uff09\u3068\u3057\u3066\u73fe\u308c\u3001\u305d\u308c\u304c\u5e79\u7d30\u80de\u306e\u50cd\u304d\u3092\u4e71\u3059\u6700\u521d\u306e\u5f15\u304d\u91d1\u306b\u306a\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u5b9f\u9a13\u3067\u306f\u3001\u4ee3\u8868\u7684\u306a\u6d3b\u6027\u9178\u7d20\u306e\u4e00\u7a2e\u3067\u3042\u308b\u300c\u904e\u9178\u5316\u6c34\u7d20\uff08hydrogen peroxide\uff09\u300d\u3092\u76ae\u819a\u306b\u5857\u5e03\u3059\u308b\u3060\u3051\u3067\u3082\u3001HFSCs\u304c\u672c\u6765\u306e\u6bdb\u5305\u5e79\u7d30\u80de\u3068\u3057\u3066\u306e\u3075\u308b\u307e\u3044\u3092\u3084\u3081\u3066\u3057\u307e\u3044\u3001\u300c\u8868\u76ae\u7d30\u80de\uff08epidermal cells\uff09\u300d\u3078\u3068\u5206\u5316\u3057\u3066\u3057\u307e\u3046\u73fe\u8c61\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3064\u307e\u308a\u3001\u708e\u75c7\u304c\u59cb\u307e\u308b\u3088\u308a\u3082\u524d\u306b\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3060\u3051\u3067\u5e79\u7d30\u80de\u306e\u300c\u30a2\u30a4\u30c7\u30f3\u30c6\u30a3\u30c6\u30a3\u300d\u3084\u904b\u547d\u3092\u5927\u304d\u304f\u5909\u3048\u3066\u3057\u307e\u3046\u529b\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u3001\u660e\u78ba\u306b\u793a\u3055\u308c\u305f\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/31178833_s.jpg\" alt=\"\u826f\u3044\u8272\" class=\"wp-image-7405\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/31178833_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/31178833_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/31178833_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u8131\u6bdb\u3092\u9632\u3050\u306b\u306f\u3069\u3046\u3059\u308c\u3070\u3044\u3044\uff1f \u52b9\u679c\u7684\u306a\u4ecb\u5165\u6cd5\u3068\u306f<\/h2>\n\n\n\n<p>\u9ad8\u8102\u80aa\u98df\uff08high-fat diet\uff1aHFD\uff09\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u8131\u6bdb\u3092\u9632\u3044\u3060\u308a\u3001\u5143\u306e\u72b6\u614b\u306b\u623b\u3057\u305f\u308a\u3059\u308b\u65b9\u6cd5\u306b\u3064\u3044\u3066\u3082\u3001\u3055\u307e\u3056\u307e\u306a\u5b9f\u9a13\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u307e\u305a\u8a66\u3055\u308c\u305f\u306e\u306f\u3001\u6297\u9178\u5316\u5264\uff08antioxidants\uff09\u306e\u6295\u4e0e\u3001IL-1\u30b7\u30b0\u30ca\u30eb\uff08interleukin-1 signaling\uff09\u3092\u6291\u3048\u308b\u305f\u3081\u306e\u907a\u4f1d\u5b50\u64cd\u4f5c\u3001\u305d\u3057\u3066\u5e79\u7d30\u80de\u306e\u5b89\u5b9a\u306b\u95a2\u308f\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u300cCOL17A1\uff08collagen type XVII alpha 1 chain\uff09\u300d\u3092\u5f37\u5236\u7684\u306b\u767a\u73fe\u3055\u305b\u308b\u65b9\u6cd5\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u3089\u306e\u624b\u6cd5\u3067\u306f\u3001\u6bdb\u306e\u6b63\u5e38\u306a\u518d\u751f\u3092\u53d6\u308a\u623b\u3059\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-2-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001\u6bdb\u5305\u5e79\u7d30\u80de\uff08hair follicle stem cells\uff1aHFSCs\uff09\u306e\u6d3b\u6027\u306b\u6df1\u304f\u95a2\u308f\u308b\u300cSonic Hedgehog\u7d4c\u8def\uff08Sonic Hedgehog pathway\uff1aSHH\u7d4c\u8def\uff09\u300d\u306b\u6ce8\u76ee\u3057\u305f\u4ecb\u5165\u3067\u306f\u3001\u6539\u5584\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u5177\u4f53\u7684\u306b\u306f\u3001SHH\u7d4c\u8def\u3092\u907a\u4f1d\u7684\u306b\u6d3b\u6027\u5316\u3057\u305f\u308a\u3001\u300cSAG\uff08Smoothened agonist\uff09\u300d\u3068\u3044\u3046SHH\u7d4c\u8def\u3092\u523a\u6fc0\u3059\u308b\u7269\u8cea\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001HFD\u30de\u30a6\u30b9\u306b\u304a\u3044\u3066HFSCs\u306e\u6a5f\u80fd\u304c\u90e8\u5206\u7684\u306b\u56de\u5fa9\u3057\u3001\u6bdb\u306e\u518d\u751f\u304c\u4fc3\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001\u3053\u308c\u3089\u306e\u52b9\u679c\u306fHFD\u306b\u3088\u308b\u8131\u6bdb\u306b\u9650\u3089\u308c\u305f\u3082\u306e\u3067\u3042\u308a\u3001\u52a0\u9f62\u306b\u3088\u3063\u3066\u81ea\u7136\u306b\u8d77\u3053\u308bHFSCs\u306e\u6a5f\u80fd\u4f4e\u4e0b\u306b\u306f\u52b9\u679c\u304c\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3064\u307e\u308a\u3001SHH\u7d4c\u8def\u306e\u50cd\u304d\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3044\u3046\u5f31\u70b9\u306f\u3001\u80a5\u6e80\u306b\u7279\u6709\u306e\u73fe\u8c61\u3067\u3042\u308a\u3001\u52a0\u9f62\u3068\u306f\u7570\u306a\u308b\u4ed5\u7d44\u307f\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"480\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/24431452_s.jpg\" alt=\"\u3067\u3076\u732b\" class=\"wp-image-7408\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/24431452_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/24431452_s-300x225.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/24431452_s-485x364.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u80a5\u6e80\u306f\u672c\u5f53\u306b\u8001\u5316\u3092\u65e9\u3081\u308b\u306e\u304b\uff1f \u5e79\u7d30\u80de\u304b\u3089\u898b\u3048\u3066\u304d\u305f\u65b0\u305f\u306a\u53ef\u80fd\u6027<\/h2>\n\n\n\n<p>\u9ad8\u8102\u80aa\u98df\uff08high-fat diet\uff1aHFD\uff09\u306e\u5f71\u97ff\u304c\u6642\u9593\u3068\u3068\u3082\u306b\u3069\u306e\u3088\u3046\u306b\u84c4\u7a4d\u3055\u308c\u308b\u306e\u304b\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u3001\u7814\u7a76\u8005\u305f\u3061\u306f\u8907\u6570\u306e\u6bdb\u5468\u671f\uff08hair cycle\uff09\u306b\u308f\u305f\u3063\u3066\u30de\u30a6\u30b9\u306e\u6bdb\u5305\u5e79\u7d30\u80de\uff08hair follicle stem cells\uff1aHFSCs\uff09\u306e\u72b6\u614b\u3092\u89b3\u5bdf\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-2-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<p>\u305d\u306e\u7d50\u679c\u3001HFD\u3092\u4e0e\u3048\u3089\u308c\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u6bdb\u5468\u671f\u304c\u7e70\u308a\u8fd4\u3055\u308c\u308b\u3054\u3068\u306bHFSCs\u3078\u306e\u30c0\u30e1\u30fc\u30b8\u304c\u5f90\u3005\u306b\u84c4\u7a4d\u3057\u3066\u3044\u304f\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u300c\u7d2f\u7a4d\u7684\u306a\u640d\u50b7\uff08cumulative damage\uff09\u300d\u306f\u3001\u80a5\u6e80\u304c\u5358\u306a\u308b\u8131\u6bdb\u306e\u539f\u56e0\u306b\u306a\u308b\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u518d\u751f\u80fd\u529b\u306e\u4f4e\u4e0b\u3084\u8001\u5316\u306e\u9032\u884c\u3092\u65e9\u3081\u308b\u300c\u5897\u5e45\u56e0\u5b50\uff08amplifier\uff09\u300d\u3068\u3057\u3066\u50cd\u304f\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"428\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/23847484_s.jpg\" alt=\"\u4eba\u306f\u8001\u3051\u308b\" class=\"wp-image-7411\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/23847484_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/23847484_s-300x201.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/23847484_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306a\u7d50\u679c\u306f\u3001\u300c\u5e79\u7d30\u80de\u306e\u75b2\u5f0a\uff08exhaustion\uff09\u300d\u300c\u8aa4\u3063\u305f\u5206\u5316\uff08misdifferentiation\uff09\u300d\u300c\u6d88\u5931\uff08depletion\uff09\u300d\u3068\u3044\u3063\u305f\u7d30\u80de\u30ec\u30d9\u30eb\u306e\u5909\u5316\u304c\u3001\u7d44\u7e54\u306e\u8001\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059\u3068\u3044\u3046\u3001\u65b0\u3057\u3044\u300c\u5e79\u7d30\u80de\u4e2d\u5fc3\u306e\u8001\u5316\u7406\u8ad6\uff08stem cell\u2013centric theory of aging\uff09\u300d\u3092\u5f37\u304f\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4eca\u56de\u306e\u7814\u7a76\u306f\u30de\u30a6\u30b9\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3082\u306e\u3067\u3059\u304c\u3001\u3082\u3057\u540c\u69d8\u306e\u4ed5\u7d44\u307f\u304c\u4eba\u9593\u306e\u76ae\u819a\u3084\u9aea\u306b\u3082\u5f53\u3066\u306f\u307e\u308b\u306e\u3067\u3042\u308c\u3070\u3001\u80a5\u6e80\u306f\u898b\u305f\u76ee\u306e\u8001\u5316\u3084\u8131\u6bdb\u306e\u9032\u884c\u3092\u52a0\u901f\u3055\u305b\u308b\u91cd\u8981\u306a\u8981\u56e0\u306b\u306a\u308a\u5f97\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3064\u307e\u308a\u3001\u79c1\u305f\u3061\u304c\u65e5\u3005\u306e\u98df\u751f\u6d3b\u3084\u751f\u6d3b\u7fd2\u6163\u3092\u898b\u76f4\u3059\u3053\u3068\u306f\u3001\u7cd6\u5c3f\u75c5\u3084\u5fc3\u8840\u7ba1\u75be\u60a3\u3068\u3044\u3063\u305f\u4ee3\u8b1d\u6027\u75be\u60a3\u3092\u4e88\u9632\u3059\u308b\u305f\u3081\u3060\u3051\u3067\u306a\u304f\u3001\u5e79\u7d30\u80de\u306e\u529b\u3092\u5b88\u308a\u3001\u9aea\u3084\u808c\u306e\u82e5\u3005\u3057\u3055\u3092\u4fdd\u3064\u305f\u3081\u306b\u3082\u5927\u5207\u3060\u3068\u8003\u3048\u3089\u308c\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/24512914_s-1.jpg\" alt=\"\u3055\u3089\u3055\u3089\" class=\"wp-image-7227\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/24512914_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/24512914_s-1-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/24512914_s-1-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-2-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>\u80a5\u6e80, \u5e79\u7d30\u80de, \u6bdb\u5305, \u6bdb\u5305\u5e79\u7d30\u80de, \u518d\u751f\u529b, \u9ad8\u8102\u80aa\u98df, \u8131\u6bdb, \u6bdb\u5468\u671f, \u30b3\u30e9\u30fc\u30b2\u30f317\u578b, IL-1\u03b2, \u9178\u5316\u30b9\u30c8\u30ec\u30b9, NF-\u03baB, Sonic Hedgehog\u7d4c\u8def, SHH\u7d4c\u8def, \u904b\u547d\u8ee2\u63db, \u7570\u5e38\u5206\u5316, \u8868\u76ae\u5e79\u7d30\u80de, \u30ea\u30dd\u30c8\u30ad\u30b7\u30b7\u30c6\u30a3, \u8102\u80aa\u6ef4, \u52a0\u9f62<\/sup><\/p>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-2-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/32029542_s-1.jpg\" alt=\"\u307d\u3061\" class=\"wp-image-7414\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/32029542_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/32029542_s-1-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/03\/32029542_s-1-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03624-x\">Morinaga, H., Mohri, Y., Grachtchouk, M. et al. Obesity accelerates hair thinning by stem cell-centric converging mechanisms. Nature 595, 266\u2013271 (2021). https:\/\/doi.org\/10.1038\/s41586-021-03624-x<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03819-2\">Jumper, J., Evans, R., Pritzel, A. <em>et al.<\/em> Highly accurate protein structure prediction with AlphaFold. <em>Nature<\/em> 596, 583\u2013589 (2021). https:\/\/doi.org\/10.1038\/s41586-021-03819-2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1011\">Mihaly Varadi, Damian Bertoni, Paulyna Magana, Urmila Paramval, Ivanna Pidruchna, Malarvizhi Radhakrishnan, Maxim Tsenkov, Sreenath Nair, Milot Mirdita, Jingi Yeo, Oleg Kovalevskiy, Kathryn Tunyasuvunakool, Agata Laydon, Augustin \u017d\u00eddek, Hamish Tomlinson, Dhavanthi Hariharan, Josh Abrahamson, Tim Green, John Jumper, Ewan Birney, Martin Steinegger, Demis Hassabis, Sameer Velankar, AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences, <em>Nucleic Acids Research<\/em>, Volume 52, Issue D1, 5 January 2024, Pages D368\u2013D375, https:\/\/doi.org\/10.1093\/nar\/gkad1011<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae974\">Perez, G., Barber, G. P., Benet-Pages, A., Casper, J., Clawson, H., Diekhans, M., Fischer, C., Gonzalez, J. N., Hinrichs, A. S., Lee, C. M., Nassar, L. R., Raney, B. J., Speir, M. L., van Baren, M. J., Vaske, C. J., Haussler, D., Kent, W. J., &amp; Haeussler, M. (2025). The UCSC Genome Browser database: 2025 update. <em>Nucleic acids research<\/em>, <em>53<\/em>(D1), D1243\u2013D1249. https:\/\/doi.org\/10.1093\/nar\/gkae974<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/burnst\/tkac022\">Wang, X., Liu, Y., He, J., Wang, J., Chen, X., &amp; Yang, R. (2022). Regulation of signaling pathways in hair follicle stem cells. <em>Burns &amp; Trauma<\/em>, <em>10<\/em>, tkac022. https:\/\/doi.org\/10.1093\/burnst\/tkac022<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/nm.3651\">Oh, J., Lee, Y. D., &amp; Wagers, A. J. (2014). Stem cell aging: mechanisms, regulators and therapeutic opportunities.&nbsp;<em>Nature medicine<\/em>,&nbsp;<em>20<\/em>(8), 870\u2013880. https:\/\/doi.org\/10.1038\/nm.3651<\/a><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><p><a class=\"category_bnr\" href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=shokumou\"><br \/>\n<img decoding=\"async\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/03\/column-bnr-2-1.webp\"><br \/>\n<\/a><\/p>\n<style>\n.category_bnr{\n  width:90%;\n  max-width:600px;\n  display:block;\n  margin:1rem auto;\n}\n<\/style>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u65e5\u3005\u306e\u98df\u4e8b\u3084\u751f\u6d3b\u7fd2\u6163\u304c\u3001\u9aea\u306e\u5143\u6c17\u3084\u808c\u306e\u82e5\u3005\u3057\u3055\u306b\u307e\u3067\u5f71\u97ff\u3059\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u805e\u3044\u305f\u3089\u9a5a\u304f\u3067\u3057\u3087\u3046\u304b\uff1f\u5b9f\u306f\u300c\u80a5\u6e80\u300d\u304c\u3001\u4f53\u306e\u4e2d\u3067\u518d\u751f\u3084\u4fee\u5fa9\u3092\u62c5\u3046\u300c\u5e79\u7d30\u80de\u300d\u306e\u50cd\u304d\u3092\u5f31\u3081\u308b\u3053\u3068\u3067\u3001\u9aea\u304c\u7d30\u304f\u306a\u3063\u305f\u308a\u3001\u898b\u305f\u76ee\u3060\u3051\u3067\u306a\u304f\u5b9f\u969b\u306b\u8001\u3051\u3084\u3059\u304f\u306a\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u7814\u7a76\u306e\u6839\u62e0\u3092\u3082\u3068\u306b\u3001\u80a5\u6e80\u3068\u9aea\u3084\u808c\u306e\u5909\u5316\u306e\u95a2\u4fc2\u3092\u308f\u304b\u308a\u3084\u3059\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002 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