{"id":9764,"date":"2025-05-09T08:42:55","date_gmt":"2025-05-09T08:42:55","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/?p=9764"},"modified":"2025-05-09T08:42:57","modified_gmt":"2025-05-09T08:42:57","slug":"hair-cloning-stem-cells","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/hair-cloning-stem-cells\/","title":{"rendered":"\u5e79\u7d30\u80de\u3068\u6bdb\u5305\u518d\u751f\u3067\u3088\u307f\u304c\u3048\u308b\u9aea\u306e\u672a\u6765\u2500\u2500\u30d8\u30a2\u30fb\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u6700\u524d\u7dda"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u6bdb\u9aea\u79d1\u5b66\u306e\u6700\u524d\u7dda\uff1a\u6bdb\u5305\u7d30\u80de\u79fb\u690d\u3068\u5e79\u7d30\u80de\u306b\u3088\u308b\u767a\u6bdb\u6cbb\u7642\u306e\u6700\u65b0\u30ec\u30d3\u30e5\u30fc<\/h2>\n\n\n\n<div style=\"height:22px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/05\/31517606_s.jpg\" alt=\"\u6bdb\u5305\u518d\u751f\u306b\u3088\u308b\u767a\u6bdb\u6cbb\u7642\u306e\u52b9\u679c\u3092\u5b9f\u611f\u3059\u308b\u3088\u3046\u306b\u3001\u3042\u3054\u306e\u30e9\u30a4\u30f3\u3092\u306a\u305e\u308b\u5973\u6027\u3002\u3086\u308b\u3084\u304b\u306b\u30ab\u30fc\u30eb\u3057\u305f\u9577\u3044\u9aea\u304c\u80a9\u306b\u304b\u304b\u308a\u3001\u5065\u5eb7\u7684\u306a\u9aea\u306e\u7f8e\u3057\u3055\u3068\u518d\u751f\u533b\u7642\u306b\u3088\u308b\u8584\u6bdb\u5bfe\u7b56\u306e\u53ef\u80fd\u6027\u3092\u8868\u73fe\u3057\u3066\u3044\u308b\u30a4\u30e1\u30fc\u30b8\u3002\" class=\"wp-image-9771\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/05\/31517606_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/05\/31517606_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/05\/31517606_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:22px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u8a18\u4e8b\u3067\u306f\u3001\u8fd1\u5e74\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u6bdb\u5305\u7d30\u80de<a href=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/minimally-invasive-hair-transplant\/\">\u79fb\u690d<\/a>\uff08\u3044\u308f\u3086\u308b\u300c\u30d8\u30a2\u30fb\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u300d\uff09\u304a\u3088\u3073\u5e79\u7d30\u80de\u306b\u3088\u308b\u767a\u6bdb\u6cbb\u7642\u306b\u95a2\u3059\u308b\u6700\u65b0\u7814\u7a76\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002\u7279\u306b\u3001Cotsarelis\uff08\u30b3\u30c4\u30a1\u30ec\u30ea\u30b9\uff09\u535a\u58eb\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306b\u3088\u308b\u753b\u671f\u7684\u306a\u5831\u544a\uff08Yang\u3089\u306b\u3088\u308b\u8ad6\u6587\uff09\u3092\u4e2d\u5fc3\u306b\u89e3\u8aac\u3057\u307e\u3059\u3002\u3053\u306e\u5206\u91ce\u306e\u7814\u7a76\u306f\u65e5\u3005\u8907\u96d1\u5316\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u540c\u6642\u306b\u5c06\u6765\u306e\u7d30\u80de\u6cbb\u7642\u3078\u306e\u5927\u304d\u306a\u5e0c\u671b\u3082\u4e0e\u3048\u3066\u304f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"short-code\">\n<span class=\"c-liner\">\u81ea\u4fe1\u3092\u53d6\u308a\u623b\u3059\u3001\u6700\u9069\u306a\u690d\u6bdb<\/span><\/p>\n<div class=\"short-button\"><a href=\"https:\/\/hiro-clinic.reserve.ne.jp\/sp\/index.php?\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/a><\/div>\n<\/div>\n<style>\n.short-code{\n text-align: center;\n background-color: var(--stk-editor-color3);\n padding: 20px 0;\n border-top: dashed 2px #ffbb00;\n border-bottom: dashed 2px #ffbb00;\n}\n.short-code p{\n margin-bottom: 5px;\n font-weight: 600;\n}\n.short-code p span{\n position: relative;\n background-image: linear-gradient(to bottom, rgba(255, 255, 255, 0) 70%, var(--stk-maker-yellow, \"#ffd5d5\") 30%);\n}\n.short-code p span::before, .short-code p span::after{\n content: \"\";\n display: inline-block;\n position: absolute;\n bottom: 0;\n background-color: #333;\n width: 1px;\n height: 16px;\n}\n.short-code p span::before{\n transform: rotate(-18deg);\n left: -10px;\n}\n.short-code p span::after{\n right: -10px;\n transform: rotate(18deg);\n}\n.short-button a {\n position: relative;\n display: flex;\n justify-content: space-around;\n align-items: center;\n margin: auto;\n max-width: 250px;\n padding: 10px 25px;\n color: #333;\n font-family: \"Noto Sans Japanese\";\n text-decoration: none;\n color: #fff;\n line-height: 1.8;\n transition: 0.3s ease-in-out;\n font-weight: 700;\n background: #ff8300;\n border-radius: 9999px;\n border-bottom: solid 5px #af4f00;\n}\n.short-button a:hover {\n border-bottom: solid 2px #af4f00;\n transform: translateY(3px);\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u6bdb\u5305\u7d30\u80de\u3092\u7528\u3044\u305f\u767a\u6bdb\u6cbb\u7642\uff1a\u57fa\u672c\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1<\/h2>\n\n\n\n<div style=\"height:22px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/hair-transplantation\/wp-content\/uploads\/2025\/05\/23309835_s.jpg\" alt=\"\u81ea\u6bdb\u690d\u6bdb\u624b\u8853\u3092\u63a7\u3048\u305f\u5973\u6027\u304c\u5e02\u8ca9\u85ac\u306e\u670d\u7528\u3092\u305f\u3081\u3089\u3046\u69d8\u5b50\u3092\u8868\u3059\u30a4\u30e1\u30fc\u30b8\u5199\u771f\u3002\u670d\u85ac\u306e\u81ea\u5df1\u5224\u65ad\u304c\u624b\u8853\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\" class=\"wp-image-9360\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/05\/23309835_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/05\/23309835_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/wp-content\/uploads\/2025\/05\/23309835_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:22px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/about_natural-pro\/\">\u8584\u6bdb<\/a>\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/minimally-invasive-hair-transplant\/\">\u79fb\u690d<\/a>\u3055\u308c\u308b\u7d30\u80de\u304c\u3069\u306e\u3088\u3046\u306b\u6a5f\u80fd\u3059\u308b\u304b\u306f\u591a\u5c90\u306b\u308f\u305f\u308a\u307e\u3059\u3002\u7406\u89e3\u3092\u52a9\u3051\u308b\u305f\u3081\u306b\u3001\u4e3b\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u30924\u3064\u306e\u30d1\u30bf\u30fc\u30f3\u306b\u5206\u985e\u3067\u304d\u307e\u3059\uff08\u56f31\u53c2\u7167\uff09\uff1a<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u65b0\u3057\u3044\u6bdb\u5305\u306e\u518d\u751f\uff08follicular neogenesis\uff09\u3092\u76ee\u7684\u3068\u3057\u305f\u65b9\u6cd5\u3067\u306f\u3001\u60a3\u8005\u81ea\u8eab\u306e\u6bdb\u5305\u304b\u3089\u63a1\u53d6\u3057\u305f\u7d30\u80de\uff08\u305f\u3068\u3048\u3070\u771f\u76ae\u4e73\u982d\u7d30\u80de\uff1adermal papilla cells\uff09\u3092\u4f53\u5916\u3067\u57f9\u990a\u30fb\u5897\u6b96\u3055\u305b\u3001\u5206\u6563\u72b6\u614b\u3067\u76ae\u819a\u3078\u6ce8\u5165\u3057\u307e\u3059\uff08\u56f31A\uff09\u3002\u3053\u308c\u306f\u7406\u8ad6\u7684\u306b\u306f\u65b0\u305f\u306a\u6bdb\u5305\u3092\u4f5c\u308a\u51fa\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u904e\u53bb10\u5e74\u9593\u306e\u8a66\u307f\u3067\u306f\u6210\u529f\u4f8b\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<br><\/li>\n\n\n\n<li>\u65e2\u5b58\u306e\u6bdb\u5305\u306b\u7d30\u80de\u3092<a href=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/minimally-invasive-hair-transplant\/\">\u79fb\u690d<\/a>\u3057\u3001\u4f9b\u4e0e\u7d30\u80de\u306e\u7279\u6027\u3092\u840e\u7e2e\u3057\u305f\u6bdb\u5305\u306b\u4f1d\u3048\u308b\u3053\u3068\u3067\u767a\u6bdb\u3092\u4fc3\u3059\u65b9\u6cd5\u3082\u3042\u308a\u307e\u3059\uff08\u56f31B\uff09\u3002\u3053\u308c\u306f\u30ab\u30ca\u30c0\u306eRepliCel\u793e\u304c\u9032\u3081\u3066\u3044\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3001\u771f\u76ae\u9798\u30ab\u30c3\u30d7\u7d30\u80de\uff08dermal sheath cup cells\uff09\u3092\u7528\u3044\u3066\u3044\u307e\u3059\u3002<br><\/li>\n\n\n\n<li>\u6bdb\u5305\u3092\u4f53\u5916\uff08\u57f9\u990a\u76bf\uff09\u3067\u518d\u69cb\u7bc9\u3057\u305f\u308a\uff08\u56f31C\uff09\u3001\u3042\u308b\u3044\u306f\u52d5\u7269\u306e\u4f53\u5185\uff08\u514d\u75ab\u4e0d\u5168\u30de\u30a6\u30b9\u306a\u3069\uff09\u3092\u4e2d\u9593\u5bbf\u4e3b\u3068\u3057\u3066\u6bdb\u5305\u3092\u5f62\u6210\u3055\u305b\u305f\u4e0a\u3067\u3001\u305d\u308c\u3092\u5916\u79d1\u7684\u306b<a href=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/minimally-invasive-hair-transplant\/\">\u79fb\u690d<\/a>\u3059\u308b\u65b9\u6cd5\u3082\u3042\u308a\u307e\u3059\uff08\u56f31D\uff09\u3002\u3053\u306e\u65b9\u6cd5\u3067\u306f\u5f93\u6765\u306e\u81ea\u6bdb<a href=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/\">\u690d\u6bdb<\/a>\u3068\u540c\u69d8\u306e\u624b\u6280\u304c\u53ef\u80fd\u3067\u3059\u3002<br><\/li>\n<\/ol>\n\n\n<div class=\"custom-html\"><div class=\"short-code\">\n<span class=\"c-liner\">\u81ea\u4fe1\u3092\u53d6\u308a\u623b\u3059\u3001\u6700\u9069\u306a\u690d\u6bdb<\/span><\/p>\n<div class=\"short-button\"><a href=\"https:\/\/hiro-clinic.reserve.ne.jp\/sp\/index.php?\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/a><\/div>\n<\/div>\n<style>\n.short-code{\n text-align: center;\n background-color: var(--stk-editor-color3);\n padding: 20px 0;\n border-top: dashed 2px #ffbb00;\n border-bottom: dashed 2px #ffbb00;\n}\n.short-code p{\n margin-bottom: 5px;\n font-weight: 600;\n}\n.short-code p span{\n position: relative;\n background-image: linear-gradient(to bottom, rgba(255, 255, 255, 0) 70%, var(--stk-maker-yellow, \"#ffd5d5\") 30%);\n}\n.short-code p span::before, .short-code p span::after{\n content: \"\";\n display: inline-block;\n position: absolute;\n bottom: 0;\n background-color: #333;\n width: 1px;\n height: 16px;\n}\n.short-code p span::before{\n transform: rotate(-18deg);\n left: -10px;\n}\n.short-code p span::after{\n right: -10px;\n transform: rotate(18deg);\n}\n.short-button a {\n position: relative;\n display: flex;\n justify-content: space-around;\n align-items: center;\n margin: auto;\n max-width: 250px;\n padding: 10px 25px;\n color: #333;\n font-family: \"Noto Sans Japanese\";\n text-decoration: none;\n color: #fff;\n line-height: 1.8;\n transition: 0.3s ease-in-out;\n font-weight: 700;\n background: #ff8300;\n border-radius: 9999px;\n border-bottom: solid 5px #af4f00;\n}\n.short-button a:hover {\n border-bottom: solid 2px #af4f00;\n transform: translateY(3px);\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5e79\u7d30\u80de\u306e\u53ef\u80fd\u6027\u3068\u9650\u754c\uff1a\u7121\u9650\u306b\u5897\u3084\u305b\u308b\u6bdb\u5305\u5e79\u7d30\u80de\u306f\u5b9f\u73fe\u3059\u308b\u306e\u304b\uff1f<\/h2>\n\n\n\n<p>\u3053\u308c\u307e\u3067\u3001\u7d30\u80de\u306e\u4f9b\u7d66\u6e90\u306f\u60a3\u8005\u81ea\u8eab\u306e\u6bdb\u5305\u306b\u9650\u3089\u308c\u3066\u304a\u308a\u3001\u7279\u306b\u4e0a\u76ae\u5e79\u7d30\u80de\uff08epithelial stem cells\uff09\u306e\u7372\u5f97\u304c\u5927\u304d\u306a\u5236\u9650\u3068\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u5e79\u7d30\u80de\u306f\u305d\u306e\u6027\u8cea\u4e0a\u3001\u4f53\u5185\u306b\u3054\u304f\u5c11\u91cf\u3057\u304b\u5b58\u5728\u305b\u305a\u3001\u63a1\u53d6\u306b\u3082\u9650\u754c\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u4eba\u5de5\u591a\u80fd\u6027\u5e79\u7d30\u80de\uff08iPSC\uff1ainduced pluripotent stem cells\uff09\u306e\u6280\u8853\u306b\u3088\u308a\u3001\u3053\u306e\u58c1\u3092\u6253\u3061\u7834\u308b\u53ef\u80fd\u6027\u304c\u51fa\u3066\u304d\u307e\u3057\u305f\u3002iPSC\u3068\u306f\u3001\u901a\u5e38\u306e\u4f53\u7d30\u80de\uff08\u4f8b\uff1a\u76ae\u819a\u306e\u7dda\u7dad\u82bd\u7d30\u80de\u306a\u3069\uff09\u306b\u7279\u5b9a\u306e\u56e0\u5b50\uff08c-MYC\u3001SOX2\u3001KLF4\u3001OCT4\uff09\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u3001\u80da\u6027\u5e79\u7d30\u80de\u306e\u3088\u3046\u306a\u591a\u80fd\u6027\u3092\u6301\u305f\u305b\u305f\u7d30\u80de\u306e\u3053\u3068\u3067\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u7406\u8ad6\u4e0a\u306f\u3069\u3093\u306a\u7d30\u80de\u306b\u3082\u5909\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"short-code\">\n<span class=\"c-liner\">\u81ea\u4fe1\u3092\u53d6\u308a\u623b\u3059\u3001\u6700\u9069\u306a\u690d\u6bdb<\/span><\/p>\n<div class=\"short-button\"><a href=\"https:\/\/hiro-clinic.reserve.ne.jp\/sp\/index.php?\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/a><\/div>\n<\/div>\n<style>\n.short-code{\n text-align: center;\n background-color: var(--stk-editor-color3);\n padding: 20px 0;\n border-top: dashed 2px #ffbb00;\n border-bottom: dashed 2px #ffbb00;\n}\n.short-code p{\n margin-bottom: 5px;\n font-weight: 600;\n}\n.short-code p span{\n position: relative;\n background-image: linear-gradient(to bottom, rgba(255, 255, 255, 0) 70%, var(--stk-maker-yellow, \"#ffd5d5\") 30%);\n}\n.short-code p span::before, .short-code p span::after{\n content: \"\";\n display: inline-block;\n position: absolute;\n bottom: 0;\n background-color: #333;\n width: 1px;\n height: 16px;\n}\n.short-code p span::before{\n transform: rotate(-18deg);\n left: -10px;\n}\n.short-code p span::after{\n right: -10px;\n transform: rotate(18deg);\n}\n.short-button a {\n position: relative;\n display: flex;\n justify-content: space-around;\n align-items: center;\n margin: auto;\n max-width: 250px;\n padding: 10px 25px;\n color: #333;\n font-family: \"Noto Sans Japanese\";\n text-decoration: none;\n color: #fff;\n line-height: 1.8;\n transition: 0.3s ease-in-out;\n font-weight: 700;\n background: #ff8300;\n border-radius: 9999px;\n border-bottom: solid 5px #af4f00;\n}\n.short-button a:hover {\n border-bottom: solid 2px #af4f00;\n transform: translateY(3px);\n}\n<\/style>\n<\/div>\n\n\n\n<p>\u3068\u306f\u3044\u3048\u3001\u3053\u308c\u307e\u3067iPSC\u304b\u3089\u6bdb\u5305\u5f62\u6210\u80fd\uff08folliculogenic capacity\uff09\u3092\u6301\u3064\u4e0a\u76ae\u5e79\u7d30\u80de\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u306f\u56f0\u96e3\u3067\u3057\u305f\u3002\u305d\u3093\u306a\u4e2d\u3001Cotsarelis\u3068Xu\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001iPSC\u304b\u3089\u30d2\u30c8\u306e\u6bdb\u5305\u5168\u4f53\u306e\u4e0a\u76ae\u5c64\u3092\u518d\u69cb\u6210\u3067\u304d\u308b\u4e0a\u76ae\u5e79\u7d30\u80de\u306e\u4f5c\u6210\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u8a98\u5c0e\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u53b3\u5bc6\u306a\u624b\u9806\u304c\u7528\u3044\u3089\u308c\u307e\u3057\u305f\uff1a<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u30ec\u30c1\u30ce\u30a4\u30f3\u9178\uff08RA\uff1aretinoic acid\uff09\u3067\u521d\u671f\u8a98\u5c0e\u3092\u884c\u3044\u3001<br><\/li>\n\n\n\n<li>\u8868\u76ae\u6210\u9577\u56e0\u5b50\uff08EGF\uff1aepidermal growth factor\uff09\u3068\u9aa8\u5f62\u6210\u56e0\u5b50\uff08BMP4\uff1abone morphogenetic protein 4\uff09\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u57f9\u990a\u3001<br><\/li>\n\n\n\n<li>\u6700\u5f8c\u306bEGF\u5358\u72ec\u3067\u6210\u719f\u3055\u305b\u308b\u3002<br><\/li>\n<\/ol>\n\n\n\n<p>\u5f97\u3089\u308c\u305f\u5e79\u7d30\u80de\u306f\u3001\u30b1\u30e9\u30c1\u30f315\uff08cytokeratin 15\uff09\u3001CD200\u3001ITGA6\u3068\u3044\u3063\u305f\u4e0a\u76ae\u5e79\u7d30\u80de\u7279\u6709\u306e\u30de\u30fc\u30ab\u30fc\u3067\u305d\u306e\u6027\u8cea\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u3053\u308c\u3089\u306e\u7d30\u80de\u3092\u771f\u76ae\u7d30\u80de\u3068\u4e00\u7dd2\u306b\u514d\u75ab\u4e0d\u5168\u30de\u30a6\u30b9\u306b\u6ce8\u5c04\u3001\u307e\u305f\u306f\u30b7\u30ea\u30b3\u30f3\u30c1\u30e3\u30f3\u30d0\u30fc\u5185\u306b<a href=\"https:\/\/www.hiro-clinic.or.jp\/hair-transplantation\/minimally-invasive-hair-transplant\/\">\u79fb\u690d<\/a>\u3059\u308b\u3068\u3001\u6b63\u5e38\u306a\u6bdb\u5305\u69cb\u9020\u3092\u6301\u3064\u6bdb\u304c\u518d\u751f\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"short-code\">\n<span class=\"c-liner\">\u81ea\u4fe1\u3092\u53d6\u308a\u623b\u3059\u3001\u6700\u9069\u306a\u690d\u6bdb<\/span><\/p>\n<div class=\"short-button\"><a href=\"https:\/\/hiro-clinic.reserve.ne.jp\/sp\/index.php?\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/a><\/div>\n<\/div>\n<style>\n.short-code{\n text-align: center;\n background-color: var(--stk-editor-color3);\n padding: 20px 0;\n border-top: dashed 2px #ffbb00;\n border-bottom: dashed 2px #ffbb00;\n}\n.short-code p{\n margin-bottom: 5px;\n font-weight: 600;\n}\n.short-code p span{\n position: relative;\n background-image: linear-gradient(to bottom, rgba(255, 255, 255, 0) 70%, var(--stk-maker-yellow, \"#ffd5d5\") 30%);\n}\n.short-code p span::before, .short-code p span::after{\n content: \"\";\n display: inline-block;\n position: absolute;\n bottom: 0;\n background-color: #333;\n width: 1px;\n height: 16px;\n}\n.short-code p span::before{\n transform: rotate(-18deg);\n left: -10px;\n}\n.short-code p span::after{\n right: -10px;\n transform: rotate(18deg);\n}\n.short-button a {\n position: relative;\n display: flex;\n justify-content: space-around;\n align-items: center;\n margin: auto;\n max-width: 250px;\n padding: 10px 25px;\n color: #333;\n font-family: \"Noto Sans Japanese\";\n text-decoration: none;\n color: #fff;\n line-height: 1.8;\n transition: 0.3s ease-in-out;\n font-weight: 700;\n background: #ff8300;\n border-radius: 9999px;\n border-bottom: solid 5px #af4f00;\n}\n.short-button a:hover {\n border-bottom: solid 2px #af4f00;\n transform: translateY(3px);\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5b89\u5168\u6027\u3078\u306e\u8ab2\u984c\uff1a\u816b\u760d\u5f62\u6210\u306e\u30ea\u30b9\u30af\u3068\u4eca\u5f8c\u306e\u5c55\u671b<\/h2>\n\n\n\n<p>iPSC\u6280\u8853\u306f\u9769\u547d\u7684\u3067\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u4f53\u7d30\u80de\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5909\u5316\u3092\u8a98\u5c0e\u3059\u308b\u56e0\u5b50\u3092\u52a0\u3048\u308b\u3068\u3044\u3046\u624b\u6cd5\u3067\u3042\u308b\u305f\u3081\u3001\u816b\u760d\u5316\u306e\u30ea\u30b9\u30af\u304c\u5e38\u306b\u61f8\u5ff5\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u7d30\u80de\u3092\u4eba\u306b\u6295\u4e0e\u3059\u308b\u306b\u306f\u3001\u5b89\u5168\u6027\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u9577\u671f\u9593\u306b\u308f\u305f\u308b\u81e8\u5e8a\u8a66\u9a13\u3084\u691c\u8a3c\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001\u6bdb\u5305\u518d\u751f\u306b\u306f\u4e0a\u76ae\u5e79\u7d30\u80de\u3060\u3051\u3067\u306a\u304f\u3001\u6bdb\u5305\u3092\u8a98\u5c0e\u3059\u308b\u771f\u76ae\u7d30\u80de\uff08hair-inducing dermal cells\uff09\u306e\u5b58\u5728\u3082\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u3053\u308c\u306b\u95a2\u9023\u3059\u308b\u6700\u5f8c\u306e\u91cd\u8981\u306a\u7814\u7a76\u3068\u3057\u3066\u306f\u30012010\u5e74\u306bPark\u3089\u304c\u5831\u544a\u3057\u305f\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002\u5f7c\u3089\u306f\u3001\u9aa8\u9ac4\u307e\u305f\u306f\u81cd\u5e2f\uff08umbilical cord\uff09\u7531\u6765\u306e\u9593\u8449\u7cfb\u5e79\u7d30\u80de\uff08mesenchymal stem cells\uff09\u3092\u771f\u76ae\u4e73\u982d\u7d30\u80de\u306b\u5909\u63db\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u306f\u3001\u30d2\u30c9\u30ed\u30b3\u30eb\u30c1\u30be\u30f3\uff08hydrocortisone\uff09\u3068\u809d\u7d30\u80de\u5897\u6b96\u56e0\u5b50\uff08HGF\uff1ahepatocyte growth factor\uff09\u3092\u542b\u3080\u8840\u6e05\u4e0d\u4f7f\u7528\u306e\u5c02\u7528\u57f9\u5730\u304c\u4f7f\u308f\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u5e79\u7d30\u80de\u751f\u7269\u5b66\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u4eca\u5f8c\u306f\u3053\u306e\u65b9\u6cd5\u3092\u6539\u826f\u3057\u305f\u5b89\u5b9a\u7684\u306a\u771f\u76ae\u7d30\u80de\u306e\u4f9b\u7d66\u65b9\u6cd5\u304c\u78ba\u7acb\u3055\u308c\u308b\u3068\u4e88\u60f3\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"short-code\">\n<span class=\"c-liner\">\u81ea\u4fe1\u3092\u53d6\u308a\u623b\u3059\u3001\u6700\u9069\u306a\u690d\u6bdb<\/span><\/p>\n<div class=\"short-button\"><a href=\"https:\/\/hiro-clinic.reserve.ne.jp\/sp\/index.php?\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/a><\/div>\n<\/div>\n<style>\n.short-code{\n text-align: center;\n background-color: var(--stk-editor-color3);\n padding: 20px 0;\n border-top: dashed 2px #ffbb00;\n border-bottom: dashed 2px #ffbb00;\n}\n.short-code p{\n margin-bottom: 5px;\n font-weight: 600;\n}\n.short-code p span{\n position: relative;\n background-image: linear-gradient(to bottom, rgba(255, 255, 255, 0) 70%, var(--stk-maker-yellow, \"#ffd5d5\") 30%);\n}\n.short-code p span::before, .short-code p span::after{\n content: \"\";\n display: inline-block;\n position: absolute;\n bottom: 0;\n background-color: #333;\n width: 1px;\n height: 16px;\n}\n.short-code p span::before{\n transform: rotate(-18deg);\n left: -10px;\n}\n.short-code p span::after{\n right: -10px;\n transform: rotate(18deg);\n}\n.short-button a {\n position: relative;\n display: flex;\n justify-content: space-around;\n align-items: center;\n margin: auto;\n max-width: 250px;\n padding: 10px 25px;\n color: #333;\n font-family: \"Noto Sans Japanese\";\n text-decoration: none;\n color: #fff;\n line-height: 1.8;\n transition: 0.3s ease-in-out;\n font-weight: 700;\n background: #ff8300;\n border-radius: 9999px;\n border-bottom: solid 5px #af4f00;\n}\n.short-button a:hover {\n border-bottom: solid 2px #af4f00;\n transform: translateY(3px);\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5e79\u7d30\u80de\u8a98\u5c0e\u306e\u65b0\u6982\u5ff5\uff1a\u7269\u7406\u7684\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u591a\u80fd\u6027\u7372\u5f97<\/h2>\n\n\n\n<p>\u5e79\u7d30\u80de\u3078\u306e\u518d\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u306f\u5fc5\u305a\u3057\u3082\u907a\u4f1d\u5b50\u56e0\u5b50\u304c\u5fc5\u8981\u3068\u306f\u9650\u3089\u306a\u3044\u53ef\u80fd\u6027\u3082\u51fa\u3066\u304d\u307e\u3057\u305f\u3002Vacanti\u3089\u306e\u7814\u7a76\u306b\u3088\u308b\u3068\u3001pH\u306e\u4f4e\u3044\u9178\u6027\u6db2\u306b30\u5206\u9593\u6f2c\u3051\u308b\u3068\u3044\u3063\u305f\u5358\u7d14\u306a\u7269\u7406\u7684\u30b9\u30c8\u30ec\u30b9\u3067\u3001\u4f53\u7d30\u80de\u304c\u5e79\u7d30\u80de\u69d8\u306b\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u300c\u523a\u6fc0\u8a98\u5c0e\u578b\u591a\u80fd\u6027\uff08stimulus-triggered acquisition of pluripotency\uff09\u300d\u3068\u3044\u3046\u65b0\u6982\u5ff5\u306f\u3001\u3042\u3089\u3086\u308b\u7d30\u80de\u304c\u518d\u3073\u5e79\u7d30\u80de\u3078\u3068\u623b\u308b\u6f5c\u5728\u80fd\u529b\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u65b9\u6cd5\u3067\u5f97\u3089\u308c\u305f\u5e79\u7d30\u80de\u306f\u3001\u5f93\u6765\u306eiPSC\u306e\u3088\u3046\u306b\u907a\u4f1d\u5b50\u3092\u5916\u90e8\u304b\u3089\u5c0e\u5165\u3057\u306a\u3044\u305f\u3081\u3001\u816b\u760d\u5f62\u6210\u30ea\u30b9\u30af\u304c\u4f4e\u3044\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059\u3002\u307e\u3060\u81e8\u5e8a\u5fdc\u7528\u306b\u306f\u81f3\u3063\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u5b89\u5168\u6027\u306e\u89b3\u70b9\u304b\u3089\u3082\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"short-code\">\n<span class=\"c-liner\">\u81ea\u4fe1\u3092\u53d6\u308a\u623b\u3059\u3001\u6700\u9069\u306a\u690d\u6bdb<\/span><\/p>\n<div class=\"short-button\"><a href=\"https:\/\/hiro-clinic.reserve.ne.jp\/sp\/index.php?\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/a><\/div>\n<\/div>\n<style>\n.short-code{\n text-align: center;\n background-color: var(--stk-editor-color3);\n padding: 20px 0;\n border-top: dashed 2px #ffbb00;\n border-bottom: dashed 2px #ffbb00;\n}\n.short-code p{\n margin-bottom: 5px;\n font-weight: 600;\n}\n.short-code p span{\n position: relative;\n background-image: linear-gradient(to bottom, rgba(255, 255, 255, 0) 70%, var(--stk-maker-yellow, \"#ffd5d5\") 30%);\n}\n.short-code p span::before, .short-code p span::after{\n content: \"\";\n display: inline-block;\n position: absolute;\n bottom: 0;\n background-color: #333;\n width: 1px;\n height: 16px;\n}\n.short-code p span::before{\n transform: rotate(-18deg);\n left: -10px;\n}\n.short-code p span::after{\n right: -10px;\n transform: rotate(18deg);\n}\n.short-button a {\n position: relative;\n display: flex;\n justify-content: space-around;\n align-items: center;\n margin: auto;\n max-width: 250px;\n padding: 10px 25px;\n color: #333;\n font-family: \"Noto Sans Japanese\";\n text-decoration: none;\n color: #fff;\n line-height: 1.8;\n transition: 0.3s ease-in-out;\n font-weight: 700;\n background: #ff8300;\n border-radius: 9999px;\n border-bottom: solid 5px #af4f00;\n}\n.short-button a:hover {\n border-bottom: solid 2px #af4f00;\n transform: translateY(3px);\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u307e\u3068\u3081\uff1a\u30d8\u30a2\u30fb\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u306e\u5922\u304c\u73fe\u5b9f\u306b\u8fd1\u3065\u3044\u3066\u3044\u308b<\/h2>\n\n\n\n<p>\u56f31\u3067\u6574\u7406\u3057\u305f\u3088\u3046\u306b\u3001\u6bdb\u9aea\u518d\u751f\u306b\u304a\u3051\u308b\u300c\u30d8\u30a2\u30fb\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u300d\u306e\u524d\u63d0\u6761\u4ef6\u306f\u5927\u304d\u304f\u5909\u308f\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u60a3\u8005\u81ea\u8eab\u306e\u6bdb\u5305\u7531\u6765\u7d30\u80de\u3060\u3051\u306b\u4f9d\u5b58\u305b\u305a\u3001\u4ed6\u306e\u7d30\u80de\u304b\u3089\u8a98\u5c0e\u3055\u308c\u305f\u300c\u6bdb\u5305\u5f62\u6210\u80fd\u3092\u6301\u3064\u5e79\u7d30\u80de\u300d\u3092\u4f7f\u7528\u3059\u308b\u53ef\u80fd\u6027\u304c\u898b\u3048\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6280\u8853\u306f\u307e\u3060\u81e8\u5e8a\u5fdc\u7528\u306b\u306f\u6642\u9593\u3092\u8981\u3057\u307e\u3059\u304c\u3001\u300c\u7121\u9650\u306e\u6bdb\u9aea\u4f9b\u7d66\u300d\u304c\u5922\u7269\u8a9e\u3067\u306f\u306a\u304f\u3001\u73fe\u5b9f\u7684\u306a\u53ef\u80fd\u6027\u3068\u3057\u3066\u8996\u91ce\u306b\u5165\u3063\u3066\u304d\u305f\u3053\u3068\u306f\u9593\u9055\u3044\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"short-code\">\n<span class=\"c-liner\">\u81ea\u4fe1\u3092\u53d6\u308a\u623b\u3059\u3001\u6700\u9069\u306a\u690d\u6bdb<\/span><\/p>\n<div class=\"short-button\"><a href=\"https:\/\/hiro-clinic.reserve.ne.jp\/sp\/index.php?\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/a><\/div>\n<\/div>\n<style>\n.short-code{\n text-align: center;\n background-color: var(--stk-editor-color3);\n padding: 20px 0;\n border-top: dashed 2px #ffbb00;\n border-bottom: dashed 2px #ffbb00;\n}\n.short-code p{\n margin-bottom: 5px;\n font-weight: 600;\n}\n.short-code p span{\n position: relative;\n background-image: linear-gradient(to bottom, rgba(255, 255, 255, 0) 70%, var(--stk-maker-yellow, \"#ffd5d5\") 30%);\n}\n.short-code p span::before, .short-code p span::after{\n content: \"\";\n display: inline-block;\n position: absolute;\n bottom: 0;\n background-color: #333;\n width: 1px;\n height: 16px;\n}\n.short-code p span::before{\n transform: rotate(-18deg);\n left: -10px;\n}\n.short-code p span::after{\n right: -10px;\n transform: rotate(18deg);\n}\n.short-button a {\n position: relative;\n display: flex;\n justify-content: space-around;\n align-items: center;\n margin: auto;\n max-width: 250px;\n padding: 10px 25px;\n color: #333;\n font-family: \"Noto Sans Japanese\";\n text-decoration: none;\n color: #fff;\n line-height: 1.8;\n transition: 0.3s ease-in-out;\n font-weight: 700;\n background: #ff8300;\n border-radius: 9999px;\n border-bottom: solid 5px #af4f00;\n}\n.short-button a:hover {\n border-bottom: solid 2px #af4f00;\n transform: translateY(3px);\n}\n<\/style>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Cooley, J. (2013). Cell-based treatments for hair loss: research update on \u201chair cloning.\u201d <em>Hair Transplant Forum International<\/em>, 23(2):47-49.<br><\/li>\n\n\n\n<li>Yang, R., et al. (2014). Generation of folliculogenic human epithelial stem cells from induced pluripotent stem cells. <em>Nature Communications<\/em>, 5:3071.<br><\/li>\n\n\n\n<li>Yoo, B.Y., et al. (2010). Application of mesenchymal stem cells derived from bone marrow and umbilical cord in human hair multiplication. <em>Journal of Dermatological Science<\/em>, 60(2):74-83.<br><\/li>\n\n\n\n<li>Obokata, H., et al. (2014). Stimulus-triggered fate conversion of somatic cells into pluripotency. <em>Nature<\/em>, 505(7485):641-647.<\/li>\n<\/ol>\n\n\n<div class=\"custom-html\"><div class=\"short-code\">\n<span class=\"c-liner\">\u81ea\u4fe1\u3092\u53d6\u308a\u623b\u3059\u3001\u6700\u9069\u306a\u690d\u6bdb<\/span><\/p>\n<div class=\"short-button\"><a href=\"https:\/\/hiro-clinic.reserve.ne.jp\/sp\/index.php?\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/a><\/div>\n<\/div>\n<style>\n.short-code{\n text-align: center;\n background-color: var(--stk-editor-color3);\n padding: 20px 0;\n border-top: dashed 2px #ffbb00;\n border-bottom: dashed 2px #ffbb00;\n}\n.short-code p{\n margin-bottom: 5px;\n font-weight: 600;\n}\n.short-code p span{\n position: relative;\n background-image: linear-gradient(to bottom, rgba(255, 255, 255, 0) 70%, var(--stk-maker-yellow, \"#ffd5d5\") 30%);\n}\n.short-code p span::before, .short-code p span::after{\n content: \"\";\n display: inline-block;\n position: absolute;\n bottom: 0;\n background-color: #333;\n width: 1px;\n height: 16px;\n}\n.short-code p span::before{\n transform: rotate(-18deg);\n left: -10px;\n}\n.short-code p span::after{\n right: -10px;\n transform: rotate(18deg);\n}\n.short-button a {\n position: relative;\n display: flex;\n justify-content: space-around;\n align-items: center;\n margin: auto;\n max-width: 250px;\n padding: 10px 25px;\n color: #333;\n font-family: \"Noto Sans Japanese\";\n text-decoration: none;\n color: #fff;\n line-height: 1.8;\n transition: 0.3s ease-in-out;\n font-weight: 700;\n background: #ff8300;\n border-radius: 9999px;\n border-bottom: solid 5px #af4f00;\n}\n.short-button a:hover {\n border-bottom: solid 2px #af4f00;\n transform: translateY(3px);\n}\n<\/style>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6bdb\u9aea\u79d1\u5b66\u306e\u6700\u524d\u7dda\uff1a\u6bdb\u5305\u7d30\u80de\u79fb\u690d\u3068\u5e79\u7d30\u80de\u306b\u3088\u308b\u767a\u6bdb\u6cbb\u7642\u306e\u6700\u65b0\u30ec\u30d3\u30e5\u30fc \u672c\u8a18\u4e8b\u3067\u306f\u3001\u8fd1\u5e74\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u6bdb\u5305\u7d30\u80de\u79fb\u690d\uff08\u3044\u308f\u3086\u308b\u300c\u30d8\u30a2\u30fb\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u300d\uff09\u304a\u3088\u3073\u5e79\u7d30\u80de\u306b\u3088\u308b\u767a\u6bdb\u6cbb\u7642\u306b\u95a2\u3059\u308b\u6700\u65b0\u7814\u7a76\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002\u7279\u306b\u3001Cotsarelis\uff08\u30b3\u30c4\u30a1\u30ec\u30ea\u30b9\uff09\u535a\u58eb\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306b\u3088\u308b\u753b\u671f\u7684\u306a\u5831\u544a\uff08Yang\u3089\u306b\u3088\u308b\u8ad6\u6587\uff09\u3092\u4e2d\u5fc3\u306b\u89e3\u8aac\u3057\u307e\u3059\u3002\u3053\u306e\u5206\u91ce\u306e\u7814\u7a76\u306f\u65e5\u3005\u8907\u96d1\u5316\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u540c\u6642\u306b\u5c06\u6765\u306e\u7d30\u80de\u6cbb\u7642\u3078\u306e\u5927\u304d\u306a\u5e0c\u671b\u3082\u4e0e\u3048\u3066\u304f\u308c\u3066\u3044\u307e\u3059\u3002 \u6bdb\u5305\u7d30\u80de\u3092\u7528\u3044\u305f\u767a\u6bdb\u6cbb\u7642\uff1a\u57fa\u672c\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1 \u8584\u6bdb\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u79fb\u690d\u3055\u308c\u308b\u7d30\u80de\u304c\u3069\u306e\u3088\u3046\u306b\u6a5f\u80fd\u3059\u308b\u304b\u306f\u591a\u5c90\u306b\u308f\u305f\u308a\u307e\u3059\u3002\u7406\u89e3\u3092\u52a9\u3051\u308b\u305f\u3081\u306b\u3001\u4e3b\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u30924\u3064\u306e\u30d1\u30bf\u30fc\u30f3\u306b\u5206\u985e\u3067\u304d\u307e\u3059\uff08\u56f31\u53c2\u7167\uff09\uff1a \u5e79\u7d30\u80de\u306e\u53ef\u80fd\u6027\u3068\u9650\u754c\uff1a\u7121\u9650\u306b\u5897\u3084\u305b\u308b\u6bdb\u5305\u5e79\u7d30\u80de\u306f\u5b9f\u73fe\u3059\u308b\u306e\u304b\uff1f \u3053\u308c\u307e\u3067\u3001\u7d30\u80de\u306e\u4f9b\u7d66\u6e90\u306f\u60a3\u8005\u81ea\u8eab\u306e\u6bdb\u5305\u306b\u9650\u3089\u308c\u3066\u304a\u308a\u3001\u7279\u306b\u4e0a\u76ae\u5e79\u7d30\u80de\uff08epithelial stem cells\uff09\u306e\u7372\u5f97\u304c\u5927\u304d\u306a\u5236\u9650\u3068\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u5e79\u7d30\u80de\u306f\u305d\u306e\u6027\u8cea\u4e0a\u3001\u4f53\u5185\u306b\u3054\u304f\u5c11\u91cf\u3057\u304b\u5b58\u5728\u305b\u305a\u3001\u63a1\u53d6\u306b\u3082\u9650\u754c\u304c\u3042\u308a\u307e\u3059\u3002 \u3057\u304b\u3057\u3001\u4eba\u5de5\u591a\u80fd\u6027\u5e79\u7d30\u80de\uff08iPSC\uff1ainduced pluripotent stem cells\uff09\u306e\u6280\u8853\u306b\u3088\u308a\u3001\u3053\u306e\u58c1\u3092\u6253\u3061\u7834\u308b\u53ef\u80fd\u6027\u304c\u51fa\u3066\u304d\u307e\u3057\u305f\u3002iPSC\u3068\u306f\u3001\u901a\u5e38\u306e\u4f53\u7d30\u80de\uff08\u4f8b\uff1a\u76ae\u819a\u306e\u7dda\u7dad\u82bd\u7d30\u80de\u306a\u3069\uff09\u306b\u7279\u5b9a\u306e\u56e0\u5b50\uff08c-MYC\u3001SOX2\u3001KLF4\u3001OCT4\uff09\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u3001\u80da\u6027\u5e79\u7d30\u80de\u306e\u3088\u3046\u306a\u591a\u80fd\u6027\u3092\u6301\u305f\u305b\u305f\u7d30\u80de\u306e\u3053\u3068\u3067\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u7406\u8ad6\u4e0a\u306f\u3069\u3093\u306a\u7d30\u80de\u306b\u3082\u5909\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002 \u3068\u306f\u3044\u3048\u3001\u3053\u308c\u307e\u3067iPSC\u304b\u3089\u6bdb\u5305\u5f62\u6210\u80fd\uff08folliculogenic capacity\uff09\u3092\u6301\u3064\u4e0a\u76ae\u5e79\u7d30\u80de\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u306f\u56f0\u96e3\u3067\u3057\u305f\u3002\u305d\u3093\u306a\u4e2d\u3001Cotsarelis\u3068Xu\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001iPSC\u304b\u3089\u30d2\u30c8\u306e\u6bdb\u5305\u5168\u4f53\u306e\u4e0a\u76ae\u5c64\u3092\u518d\u69cb\u6210\u3067\u304d\u308b\u4e0a\u76ae\u5e79\u7d30\u80de\u306e\u4f5c\u6210\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002 \u3053\u306e\u8a98\u5c0e\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u53b3\u5bc6\u306a\u624b\u9806\u304c\u7528\u3044\u3089\u308c\u307e\u3057\u305f\uff1a \u5f97\u3089\u308c\u305f\u5e79\u7d30\u80de\u306f\u3001\u30b1\u30e9\u30c1\u30f315\uff08cytokeratin 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iPSC\u6280\u8853\u306f\u9769\u547d\u7684\u3067\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u4f53\u7d30\u80de\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5909\u5316\u3092\u8a98\u5c0e\u3059\u308b\u56e0\u5b50\u3092\u52a0\u3048\u308b\u3068\u3044\u3046\u624b\u6cd5\u3067\u3042\u308b\u305f\u3081\u3001\u816b\u760d\u5316\u306e\u30ea\u30b9\u30af\u304c\u5e38\u306b\u61f8\u5ff5\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u7d30\u80de\u3092\u4eba\u306b\u6295\u4e0e\u3059\u308b\u306b\u306f\u3001\u5b89\u5168\u6027\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u9577\u671f\u9593\u306b\u308f\u305f\u308b\u81e8\u5e8a\u8a66\u9a13\u3084\u691c\u8a3c\u304c\u5fc5\u8981\u3067\u3059\u3002 \u4e00\u65b9\u3067\u3001\u6bdb\u5305\u518d\u751f\u306b\u306f\u4e0a\u76ae\u5e79\u7d30\u80de\u3060\u3051\u3067\u306a\u304f\u3001\u6bdb\u5305\u3092\u8a98\u5c0e\u3059\u308b\u771f\u76ae\u7d30\u80de\uff08hair-inducing dermal cells\uff09\u306e\u5b58\u5728\u3082\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u3053\u308c\u306b\u95a2\u9023\u3059\u308b\u6700\u5f8c\u306e\u91cd\u8981\u306a\u7814\u7a76\u3068\u3057\u3066\u306f\u30012010\u5e74\u306bPark\u3089\u304c\u5831\u544a\u3057\u305f\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002\u5f7c\u3089\u306f\u3001\u9aa8\u9ac4\u307e\u305f\u306f\u81cd\u5e2f\uff08umbilical cord\uff09\u7531\u6765\u306e\u9593\u8449\u7cfb\u5e79\u7d30\u80de\uff08mesenchymal stem cells\uff09\u3092\u771f\u76ae\u4e73\u982d\u7d30\u80de\u306b\u5909\u63db\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u306f\u3001\u30d2\u30c9\u30ed\u30b3\u30eb\u30c1\u30be\u30f3\uff08hydrocortisone\uff09\u3068\u809d\u7d30\u80de\u5897\u6b96\u56e0\u5b50\uff08HGF\uff1ahepatocyte growth factor\uff09\u3092\u542b\u3080\u8840\u6e05\u4e0d\u4f7f\u7528\u306e\u5c02\u7528\u57f9\u5730\u304c\u4f7f\u308f\u308c\u307e\u3057\u305f\u3002 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