{"id":4212,"date":"2024-09-17T22:50:44","date_gmt":"2024-09-17T13:50:44","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nippt\/forensic-sequence-structure-guide-fssg\/"},"modified":"2024-10-07T12:27:52","modified_gmt":"2024-10-07T03:27:52","slug":"forensic-sequence-structure-guide-fssg","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nippt\/forensic-sequence-structure-guide-fssg\/?lang=en","title":{"rendered":"Forensic Sequence STRucture Guide (FSSG)"},"content":{"rendered":"\n<p>The <strong>Forensic Sequence STRucture Guide (FSSG)<\/strong> refers to guidelines and guidelines specific to DNA analysis in forensic science, specifically focusing on specific DNA sequences called <strong>Short Tandem Repeats (STRs<\/strong> ).STRs are short DNA sequences repeated in the genome that vary widely from person to person and are used for personal identification in forensic applications such as criminal investigations and paternity testing.<\/p>\n\n\n\n<p>Below are details on how the FSSG is understood.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">1. <strong>What are Short Tandem Repeats (STRs)?<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>STRs<\/strong> are short sequences of DNA (usually two to six base pairs) that are repeated in succession and are found in specific genomic regions. The number of these repeats varies from person to person, making them very useful for personal identification\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"short-code\">\n<p><span>Reliable domestic inspections<\/span><br \/>Available at a clinic near you nationwide<\/p>\n<div class=\"short-button\">\n   <a href=\"https:\/\/mypage-nippt.hiro-clinic.or.jp\/register\">Make a reservation now!<\/a>\n <\/div>\n<\/div>\n<style>\n.short-code{\n text-align: center;\n background-color: var(--stk-editor-color3);\n padding: 20px 0;\n border-top: dashed 2px #ffbb00;\n border-bottom: dashed 2px #ffbb00;\n}\n.short-code p{\n margin-bottom: 5px;\n font-weight: 600;\n}\n.short-code p span{\n position: relative;\n background-image: linear-gradient(to bottom, rgba(255, 255, 255, 0) 70%, var(--stk-maker-yellow, \"#ffd5d5\") 30%);\n}\n.short-code p span::before, .short-code p span::after{\n content: \"\";\n display: inline-block;\n position: absolute;\n bottom: 0;\n background-color: #333;\n width: 1px;\n height: 16px;\n}\n.short-code p span::before{\n transform: rotate(-18deg);\n left: -10px;\n}\n.short-code p span::after{\n right: -10px;\n transform: rotate(18deg);\n}\n.short-button a {\n position: relative;\n display: flex;\n justify-content: space-around;\n align-items: center;\n margin: auto;\n max-width: 250px;\n padding: 10px 25px;\n color: #333;\n font-family: \"Noto Sans Japanese\";\n text-decoration: none;\n color: #fff;\n line-height: 1.8;\n transition: 0.3s ease-in-out;\n font-weight: 700;\n background: #ff8300;\n border-radius: 9999px;\n border-bottom: solid 5px #af4f00;\n}\n.short-button a:hover {\n border-bottom: solid 2px #af4f00;\n transform: translateY(3px);\n}\n<\/style>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">2. <strong>Use of STRs in Forensic Science<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>In forensic analysis, multiple <a href=\"https:\/\/www.hiro-clinic.or.jp\/nippt\/accuracy\/\">STR<\/a> loci are analyzed from DNA samples. For example, DNA samples from a crime scene are compared to a suspect&#8217;s DNA profile to see if there is a match.<\/li>\n\n\n\n<li><a href=\"https:\/\/www.hiro-clinic.or.jp\/nippt\/accuracy\/\">STR<\/a> analysis is the basis for forensic DNA databases in many countries, and in the United States, the Combined DNA Index System CODIS database is used to match DNA profiles with unsolved cases and suspects.<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"short-code\">\n<p><span>Reliable domestic inspections<\/span><br \/>Available at a clinic near you nationwide<\/p>\n<div class=\"short-button\">\n   <a href=\"https:\/\/mypage-nippt.hiro-clinic.or.jp\/register\">Make a reservation now!<\/a>\n <\/div>\n<\/div>\n<style>\n.short-code{\n text-align: center;\n background-color: var(--stk-editor-color3);\n padding: 20px 0;\n border-top: dashed 2px #ffbb00;\n border-bottom: dashed 2px #ffbb00;\n}\n.short-code p{\n margin-bottom: 5px;\n font-weight: 600;\n}\n.short-code p span{\n position: relative;\n background-image: linear-gradient(to bottom, rgba(255, 255, 255, 0) 70%, var(--stk-maker-yellow, \"#ffd5d5\") 30%);\n}\n.short-code p span::before, .short-code p span::after{\n content: \"\";\n display: inline-block;\n position: absolute;\n bottom: 0;\n background-color: #333;\n width: 1px;\n height: 16px;\n}\n.short-code p span::before{\n transform: rotate(-18deg);\n left: -10px;\n}\n.short-code p span::after{\n right: -10px;\n transform: rotate(18deg);\n}\n.short-button a {\n position: relative;\n display: flex;\n justify-content: space-around;\n align-items: center;\n margin: auto;\n max-width: 250px;\n padding: 10px 25px;\n color: #333;\n font-family: \"Noto Sans Japanese\";\n text-decoration: none;\n color: #fff;\n line-height: 1.8;\n transition: 0.3s ease-in-out;\n font-weight: 700;\n background: #ff8300;\n border-radius: 9999px;\n border-bottom: solid 5px #af4f00;\n}\n.short-button a:hover {\n border-bottom: solid 2px #af4f00;\n transform: translateY(3px);\n}\n<\/style>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">3. <strong>The Role of Sequencing in Forensic Science<\/strong>.<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Conventional <a href=\"https:\/\/www.hiro-clinic.or.jp\/nippt\/accuracy\/\">STR<\/a> analysis is based on measuring the length of repeated sequences, but sequencing (sequence determination) provides more detailed information, such as base-level variations (sequence polymorphisms) within repeated portions. This may further improve the ability to identify individual<\/li>\n\n\n\n<li><strong>Sequencing<\/strong> is useful in identifying differences between individuals with similar <a href=\"https:\/\/www.hiro-clinic.or.jp\/nippt\/accuracy\/\">STR<\/a> profiles because it can detect more subtle <a href=\"https:\/\/www.hiro-clinic.or.jp\/nippt\/accuracy\/\">STR<\/a> region variations.<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"short-code\">\n<p><span>Reliable domestic inspections<\/span><br \/>Available at a clinic near you nationwide<\/p>\n<div class=\"short-button\">\n   <a href=\"https:\/\/mypage-nippt.hiro-clinic.or.jp\/register\">Make a reservation now!<\/a>\n <\/div>\n<\/div>\n<style>\n.short-code{\n text-align: center;\n background-color: var(--stk-editor-color3);\n padding: 20px 0;\n border-top: dashed 2px #ffbb00;\n border-bottom: dashed 2px #ffbb00;\n}\n.short-code p{\n margin-bottom: 5px;\n font-weight: 600;\n}\n.short-code p span{\n position: relative;\n background-image: linear-gradient(to bottom, rgba(255, 255, 255, 0) 70%, var(--stk-maker-yellow, \"#ffd5d5\") 30%);\n}\n.short-code p span::before, .short-code p span::after{\n content: \"\";\n display: inline-block;\n position: absolute;\n bottom: 0;\n background-color: #333;\n width: 1px;\n height: 16px;\n}\n.short-code p span::before{\n transform: rotate(-18deg);\n left: -10px;\n}\n.short-code p span::after{\n right: -10px;\n transform: rotate(18deg);\n}\n.short-button a {\n position: relative;\n display: flex;\n justify-content: space-around;\n align-items: center;\n margin: auto;\n max-width: 250px;\n padding: 10px 25px;\n color: #333;\n font-family: \"Noto Sans Japanese\";\n text-decoration: none;\n color: #fff;\n line-height: 1.8;\n transition: 0.3s ease-in-out;\n font-weight: 700;\n background: #ff8300;\n border-radius: 9999px;\n border-bottom: solid 5px #af4f00;\n}\n.short-button a:hover {\n border-bottom: solid 2px #af4f00;\n transform: translateY(3px);\n}\n<\/style>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">4. <strong>Forensic Sequence STRucture Guide (FSSG) \u306e\u5f79\u5272<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The <strong>FSSG<\/strong> will likely provide structured guidelines for the analysis and interpretation of <a href=\"https:\/\/www.hiro-clinic.or.jp\/nippt\/accuracy\/\">STR<\/a> sequence data in forensic science. Specifically, it may include the following<\/li>\n\n\n\n<li>Protocols for <strong>DNA extraction, amplification, and sequencing of the <a href=\"https:\/\/www.hiro-clinic.or.jp\/nippt\/accuracy\/\">STR<\/a> locus<\/strong>.<\/li>\n\n\n\n<li>Guidelines for <strong>comparing and interpreting sequence data<\/strong>.<\/li>\n\n\n\n<li>Best practices to ensure the <strong>accuracy and reliability of<\/strong> sequencing used in forensic science.<\/li>\n\n\n\n<li>This guide will serve as a comprehensive reference for forensic scientists working with <a href=\"https:\/\/www.hiro-clinic.or.jp\/nippt\/accuracy\/\">STR<\/a> sequence data to ensure consistency, reproducibility, and reliability of DNA evidence for legal use.<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"short-code\">\n<p><span>Reliable domestic inspections<\/span><br \/>Available at a clinic near you nationwide<\/p>\n<div class=\"short-button\">\n   <a href=\"https:\/\/mypage-nippt.hiro-clinic.or.jp\/register\">Make a reservation now!<\/a>\n <\/div>\n<\/div>\n<style>\n.short-code{\n text-align: center;\n background-color: var(--stk-editor-color3);\n padding: 20px 0;\n border-top: dashed 2px #ffbb00;\n border-bottom: dashed 2px #ffbb00;\n}\n.short-code p{\n margin-bottom: 5px;\n font-weight: 600;\n}\n.short-code p span{\n position: relative;\n background-image: linear-gradient(to bottom, rgba(255, 255, 255, 0) 70%, var(--stk-maker-yellow, \"#ffd5d5\") 30%);\n}\n.short-code p span::before, .short-code p span::after{\n content: \"\";\n display: inline-block;\n position: absolute;\n bottom: 0;\n background-color: #333;\n width: 1px;\n height: 16px;\n}\n.short-code p span::before{\n transform: rotate(-18deg);\n left: -10px;\n}\n.short-code p span::after{\n right: -10px;\n transform: rotate(18deg);\n}\n.short-button a {\n position: relative;\n display: flex;\n justify-content: space-around;\n align-items: center;\n margin: auto;\n max-width: 250px;\n padding: 10px 25px;\n color: #333;\n font-family: \"Noto Sans Japanese\";\n text-decoration: none;\n color: #fff;\n line-height: 1.8;\n transition: 0.3s ease-in-out;\n font-weight: 700;\n background: #ff8300;\n border-radius: 9999px;\n border-bottom: solid 5px #af4f00;\n}\n.short-button a:hover {\n border-bottom: solid 2px #af4f00;\n transform: translateY(3px);\n}\n<\/style>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">5. <strong>Advanced Forensic Applications<\/strong>.<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>As sequencing technology evolves, the application of <a href=\"https:\/\/www.hiro-clinic.or.jp\/nippt\/accuracy\/\">STR<\/a> sequencing in forensic science will become more sophisticated, allowing for higher resolution in cases where traditional <a href=\"https:\/\/www.hiro-clinic.or.jp\/nippt\/accuracy\/\">STR<\/a> analysis has limitations. For example:<\/li>\n\n\n\n<li><strong>Degraded samples<\/strong> (even if fragment analysis is difficult, sequencing may provide information).<\/li>\n\n\n\n<li><strong>Complex mixtures<\/strong> (sequencing may help distinguish between multiple DNA contributors).<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"short-code\">\n<p><span>Reliable domestic inspections<\/span><br \/>Available at a clinic near you nationwide<\/p>\n<div class=\"short-button\">\n   <a href=\"https:\/\/mypage-nippt.hiro-clinic.or.jp\/register\">Make a reservation now!<\/a>\n <\/div>\n<\/div>\n<style>\n.short-code{\n text-align: center;\n background-color: var(--stk-editor-color3);\n padding: 20px 0;\n border-top: dashed 2px #ffbb00;\n border-bottom: dashed 2px #ffbb00;\n}\n.short-code p{\n margin-bottom: 5px;\n font-weight: 600;\n}\n.short-code p span{\n position: relative;\n background-image: linear-gradient(to bottom, rgba(255, 255, 255, 0) 70%, var(--stk-maker-yellow, \"#ffd5d5\") 30%);\n}\n.short-code p span::before, .short-code p span::after{\n content: \"\";\n display: inline-block;\n position: absolute;\n bottom: 0;\n background-color: #333;\n width: 1px;\n height: 16px;\n}\n.short-code p span::before{\n transform: rotate(-18deg);\n left: -10px;\n}\n.short-code p span::after{\n right: -10px;\n transform: rotate(18deg);\n}\n.short-button a {\n position: relative;\n display: flex;\n justify-content: space-around;\n align-items: center;\n margin: auto;\n max-width: 250px;\n padding: 10px 25px;\n color: #333;\n font-family: \"Noto Sans Japanese\";\n text-decoration: none;\n color: #fff;\n line-height: 1.8;\n transition: 0.3s ease-in-out;\n font-weight: 700;\n background: #ff8300;\n border-radius: 9999px;\n border-bottom: solid 5px #af4f00;\n}\n.short-button a:hover {\n border-bottom: solid 2px #af4f00;\n transform: translateY(3px);\n}\n<\/style>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Summary<\/h3>\n\n\n\n<p>The <strong>Forensic Sequence STRucture Guide (FSSG)<\/strong> could possibly provide detailed procedures and guidelines for the application of <a href=\"https:\/\/www.hiro-clinic.or.jp\/nippt\/accuracy\/\">STR<\/a> sequencing techniques to forensic investigations to enhance the accuracy and reliability of DNA evidence. The FSSG may be used as a guide to improve the accuracy and reliability of DNA evidence.<\/p>\n\n\n<div class=\"custom-html\"><div class=\"short-code\">\n<p><span>Reliable domestic inspections<\/span><br \/>Available at a clinic near you nationwide<\/p>\n<div class=\"short-button\">\n   <a href=\"https:\/\/mypage-nippt.hiro-clinic.or.jp\/register\">Make a reservation now!<\/a>\n <\/div>\n<\/div>\n<style>\n.short-code{\n text-align: center;\n background-color: var(--stk-editor-color3);\n padding: 20px 0;\n border-top: dashed 2px #ffbb00;\n border-bottom: dashed 2px #ffbb00;\n}\n.short-code p{\n margin-bottom: 5px;\n font-weight: 600;\n}\n.short-code p span{\n position: relative;\n background-image: linear-gradient(to bottom, rgba(255, 255, 255, 0) 70%, var(--stk-maker-yellow, \"#ffd5d5\") 30%);\n}\n.short-code p span::before, .short-code p span::after{\n content: \"\";\n display: inline-block;\n position: absolute;\n bottom: 0;\n background-color: #333;\n width: 1px;\n height: 16px;\n}\n.short-code p span::before{\n transform: rotate(-18deg);\n left: -10px;\n}\n.short-code p span::after{\n right: -10px;\n transform: rotate(18deg);\n}\n.short-button a {\n position: relative;\n display: flex;\n justify-content: space-around;\n align-items: center;\n margin: auto;\n max-width: 250px;\n padding: 10px 25px;\n color: #333;\n font-family: \"Noto Sans Japanese\";\n text-decoration: none;\n color: #fff;\n line-height: 1.8;\n transition: 0.3s ease-in-out;\n font-weight: 700;\n background: #ff8300;\n border-radius: 9999px;\n border-bottom: solid 5px #af4f00;\n}\n.short-button a:hover {\n border-bottom: solid 2px #af4f00;\n transform: translateY(3px);\n}\n<\/style>\n<\/div>\n\n\n\n<p>\u5f15\u7528<\/p>\n\n\n\n<p><a href=\"https:\/\/helda.helsinki.fi\/server\/api\/core\/bitstreams\/ba53dc8a-bf5c-4490-a149-9cf82c41bf49\/content\">https:\/\/helda.helsinki.fi\/server\/api\/core\/bitstreams\/ba53dc8a-bf5c-4490-a149-9cf82c41bf49\/content<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Forensic Sequence STRucture Guide (FSSG) refers to guidelines and guidelines spec&#8230;<\/p>\n","protected":false},"author":5,"featured_media":3153,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[79],"tags":[69,39,80],"class_list":{"0":"post-4212","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-str-en","8":"tag-dna_test-en","9":"tag-expert-en","10":"tag-forensic_science-en","11":"article"},"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/posts\/4212","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/comments?post=4212"}],"version-history":[{"count":17,"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/posts\/4212\/revisions"}],"predecessor-version":[{"id":5246,"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/posts\/4212\/revisions\/5246"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/media\/3153"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/media?parent=4212"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/categories?post=4212"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/tags?post=4212"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}