{"id":4434,"date":"2024-09-18T19:24:59","date_gmt":"2024-09-18T10:24:59","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nippt\/probability-of-exclusion\/"},"modified":"2024-10-07T11:39:28","modified_gmt":"2024-10-07T02:39:28","slug":"probability-of-exclusion","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nippt\/probability-of-exclusion\/?lang=zh-hans","title":{"rendered":"\u4ec0\u4e48\u662f\u6392\u9664\u6982\u7387 (PE)\uff1f"},"content":{"rendered":"\n

\u6392\u9664\u6982\u7387\uff08PE\uff09\u662f\u6307\u5982\u679c\u67d0\u4e2a\u7537\u6027\u4e0d\u662f\u5b69\u5b50\u7684\u4eb2\u751f\u7236\u4eb2\uff0cDNA \u68c0\u6d4b\u53ef\u4ee5\u51c6\u786e\u786e\u5b9a\u8fd9\u4e00\u70b9\u7684\u6982\u7387\u3002<\/strong><\/p>\n\n\n\n\n\n\n

\u6392\u9664\u6982\u7387\u4e00\u822c\u6839\u636e\u4ee5\u4e0b\u56e0\u7d20\u786e\u5b9a<\/p>\n\n\n\n

\u7b49\u4f4d\u57fa\u56e0\u7684\u9891\u7387\uff08\u7279\u5b9a\u7b49\u4f4d\u57fa\u56e0\u5728\u7fa4\u4f53\u4e2d\u7684\u5e38\u89c1\u7a0b\u5ea6\uff09 \u57fa\u56e0\u4f4d\u70b9\u6570\uff08\u6240\u7528\u6807\u8bb0\u7684\u6570\u91cf\uff09<\/p>\n\n\n\n

    \n
  1. \u6392\u9664\u6982\u7387\u7684\u57fa\u672c\u8ba1\u7b97\u516c\u5f0f \u6392\u9664\u6982\u7387\uff08PE\uff09\u662f\u901a\u8fc7\u8bc4\u4f30\u5355\u4e2a\u57fa\u56e0\u4f4d\u70b9\u975e\u4eb2\u5b50\u5173\u7cfb\u7684\u603b\u4f53\u8bc1\u636e\u6765\u8ba1\u7b97\u7684\u3002\u6392\u9664\u6982\u7387\u901a\u5e38\u662f\u901a\u8fc7\u7d2f\u79ef\u5355\u4e2a\u4f4d\u70b9\u7684\u6392\u9664\u6982\u7387\u6765\u8ba1\u7b97\u7684\u3002<\/li>\n<\/ol>\n\n\n\n

    \u4e00\u822c PE \u914d\u65b9\u5982\u4e0b<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    PE_i\uff1a\u6bcf\u4e2a\u4f4d\u70b9\uff08STR<\/a> \u6807\u8bb0\uff09\u7684\u6392\u9664\u6982\u7387 n\uff1a\u4f7f\u7528\u7684\u4f4d\u70b9\u6570\uff08\u4f8b\u5982\uff0c\u5982\u679c\u6709 20 \u4e2a\u4f4d\u70b9\uff0c\u5219 n = 20\uff09<\/p>\n\n\n\n

      \n
    1. \u6bcf\u4e2a\u57fa\u56e0\u4f4d\u70b9\u7684\u6392\u9664\u6982\u7387\uff08PE_i \u6bcf\u4e2a\u57fa\u56e0\u4f4d\u70b9\u7684\u6392\u9664\u6982\u7387\uff08PE_i\uff09\u662f\u6839\u636e\u8be5\u4f4d\u70b9\u7b49\u4f4d\u57fa\u56e0\u7684\u9891\u7387\u8ba1\u7b97\u51fa\u6765\u7684\u3002\u5177\u4f53\u6765\u8bf4\uff0c\u5b83\u8868\u793a\u63a8\u5b9a\u7684\u7236\u4eb2\u5177\u6709\u975e\u6bcd\u4eb2\u9057\u4f20\u7684\u7b49\u4f4d\u57fa\u56e0\u7684\u6982\u7387\uff08\u975e\u7236\u4eb2\u7b49\u4f4d\u57fa\u56e0\u7684\u6982\u7387\uff09\u3002<\/li>\n<\/ol>\n\n\n\n

      \u4e00\u4e2a\u4f4d\u70b9\u7684\u6392\u9664\u6982\u7387\u516c\u5f0f\u5982\u4e0b\uff1a<\/p>\n\n\n\n

      \"\"<\/figure>\n\n\n\n

      p\uff1a\u7b49\u4f4d\u57fa\u56e0 A \u5728\u57fa\u56e0\u4f4d\u70b9\u4e0a\u7684\u9891\u7387 q\uff1a\u7b49\u4f4d\u57fa\u56e0 B \u5728\u57fa\u56e0\u4f4d\u70b9\u4e0a\u7684\u9891\u7387 \u8fd9\u79cd\u8ba1\u7b97\u65b9\u6cd5\u53d6\u51b3\u4e8e\u7b49\u4f4d\u57fa\u56e0\u662f\u6742\u5408\u5b50\uff08\u5177\u6709\u4e0d\u540c\u7684\u7b49\u4f4d\u57fa\u56e0\uff09\u8fd8\u662f\u540c\u5408\u5b50\uff08\u5177\u6709\u76f8\u540c\u7684\u7b49\u4f4d\u57fa\u56e0\uff09\uff0c\u5e76\u57fa\u4e8e\u5b83\u4eec\u5404\u81ea\u7684\u6982\u7387\u3002<\/p>\n\n\n\n

        \n
      1. \u5177\u4f53\u793a\u4f8b \u4f8b\u5982\uff0c\u5982\u679c\u5728\u67d0\u4e2a\u57fa\u56e0\u5ea7\u4e0a\uff0c\u4e00\u4e2a\u7b49\u4f4d\u57fa\u56e0\u7684\u9891\u7387\u4e3a 0.2\uff0c\u53e6\u4e00\u4e2a\u7b49\u4f4d\u57fa\u56e0\u7684\u9891\u7387\u4e3a 0.3\uff0c\u90a3\u4e48\u53ef\u4ee5\u8ba1\u7b97\u5982\u4e0b\uff1a<\/li>\n<\/ol>\n\n\n\n
        \"\"<\/figure>\n\n\n\n\n\n\n

        \u9996\u5148\uff0c\u8ba1\u7b97\u5404\u81ea\u7684\u6570\u503c\uff1a<\/p>\n\n\n\n

        \"\"<\/figure>\n\n\n\n

        \u56e0\u6b64\uff0c\u7279\u5b9a\u4f4d\u70b9\u7684\u6392\u9664\u6982\u7387\u4e3a 0.84\uff0884%\uff09\u3002<\/p>\n\n\n\n

          \n
        1. \u603b\u4f53\u6392\u9664\u6982\u7387 \u5728\u6839\u636e\u591a\u4e2a\u57fa\u56e0\u4f4d\u70b9\u786e\u5b9a\u6392\u9664\u6982\u7387\u65f6\uff0c\u8981\u5c06\u6bcf\u4e2a\u4f4d\u70b9\u7684\u6392\u9664\u6982\u7387\u5408\u5e76\u3002\u4f8b\u5982\uff0c\u5982\u679c\u6709 20 \u4e2a\u57fa\u56e0\u4f4d\u70b9\uff0c\u6bcf\u4e2a\u4f4d\u70b9\u7684\u6392\u9664\u6982\u7387\uff08PE\uff09\u90fd\u5df2\u8ba1\u7b97\u51fa\u6765\uff0c\u90a3\u4e48\u5c06\u6240\u6709 PE \u76f8\u4e58\u5c31\u5f97\u5230\u4e86\u603b\u4f53\u6392\u9664\u6982\u7387\u3002<\/li>\n<\/ol>\n\n\n\n

          \u4f8b\u5982\uff0c\u5047\u8bbe\u4e09\u4e2a\u4f4d\u70b9\u7684 PE \u5206\u522b\u4e3a 0.85\u30010.9 \u548c 0.88\uff0c\u8ba1\u7b97\u65b9\u6cd5\u5982\u4e0b\uff1a<\/p>\n\n\n\n

          \"\"<\/figure>\n\n\n\n



          PE=1-(0.15)(0.1)(0.12)=1-0.0018=0.9982 \u56e0\u6b64\uff0c\u603b\u4f53\u6392\u9664\u6982\u7387\u4e3a99.82%<\/strong>\u3002<\/p>\n\n\n\n

            \n
          1. \u7ed3\u8bba \u6392\u9664\u6982\u7387\uff08PE\uff09\u662f\u6839\u636e\u6bcf\u4e2a\u4f4d\u70b9\u7684\u7b49\u4f4d\u57fa\u56e0\u9891\u7387\u8ba1\u7b97\u7684\uff0c\u4f7f\u7528\u7684\u6807\u8bb0\u8d8a\u591a\uff0c\u603b\u4f53\u6392\u9664\u6982\u7387\u8d8a\u9ad8\u3002\u6700\u7ec8\u7684\u6392\u9664\u6982\u7387\u662f\u7531\u51e0\u4e2a\u4f4d\u70b9\u7684\u6392\u9664\u6982\u7387\u76f8\u4e58\u8ba1\u7b97\u5f97\u51fa\u7684\u3002\u8be5\u503c\u8d8a\u9ad8\uff0cDNA \u68c0\u6d4b\u6392\u9664\u4eb2\u5b50\u9274\u5b9a\u7684\u6982\u7387\u5c31\u8d8a\u5927\u3002<\/li>\n<\/ol>\n\n\n\n","protected":false},"excerpt":{"rendered":"

            \u6392\u9664\u6982\u7387\uff08PE\uff09\u662f\u6307\u5982\u679c\u67d0\u4e2a\u7537\u6027\u4e0d\u662f\u5b69\u5b50\u7684\u4eb2\u751f\u7236\u4eb2\uff0cDNA \u68c0\u6d4b\u53ef\u4ee5\u51c6\u786e\u786e\u5b9a\u8fd9\u4e00\u70b9\u7684\u6982\u7387\u3002 \u6392\u9664\u6982\u7387\u4e00\u822c\u6839\u636e\u4ee5\u4e0b\u56e0\u7d20\u786e\u5b9a \u7b49\u4f4d\u57fa\u56e0\u7684\u9891\u7387\uff08\u7279\u5b9a\u7b49\u4f4d\u57fa\u56e0\u5728\u7fa4\u4f53\u4e2d\u7684\u5e38\u89c1\u7a0b\u5ea6\uff09…<\/p>\n","protected":false},"author":5,"featured_media":4119,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[35],"tags":[81,40,82,67,68],"class_list":{"0":"post-4434","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-others-zh-hans","8":"tag-dna_profiling-zh-hans","9":"tag-expert-zh-hans","10":"tag-parent_child-zh-hans","11":"tag-genetic_testing-zh-hans","12":"tag-analysis-zh-hans","13":"article"},"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/posts\/4434","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/comments?post=4434"}],"version-history":[{"count":2,"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/posts\/4434\/revisions"}],"predecessor-version":[{"id":4436,"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/posts\/4434\/revisions\/4436"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/media\/4119"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/media?parent=4434"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/categories?post=4434"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nippt\/wp-json\/wp\/v2\/tags?post=4434"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}