{"id":122115,"date":"2026-01-08T17:44:04","date_gmt":"2026-01-08T08:44:04","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/?post_type=genetic-diseases&p=122115"},"modified":"2026-01-08T17:44:05","modified_gmt":"2026-01-08T08:44:05","slug":"navajo-neurohepatopathy-mpv17-related-hepatocerebral-mitochondrial-dna-depletion-syndrome-mpv17","status":"publish","type":"genetic-diseases","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/genetic-diseases2\/navajo-neurohepatopathy-mpv17-related-hepatocerebral-mitochondrial-dna-depletion-syndrome-mpv17\/","title":{"rendered":"\u30ca\u30d0\u30db\u795e\u7d4c\u809d\u75c7\uff3bMPV17\u95a2\u9023\u809d\u7d30\u80de\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u6b20\u5931\u75c7\u5019\u7fa4\uff3d"},"content":{"rendered":"\n

\u6982\u8981<\/strong><\/h2>\n\n\n\n

\u30ca\u30d0\u30db\u795e\u7d4c\u809d\u75c7\u306f\u3001\u6838\u907a\u4f1d\u5b50MPV17\u306e\u6a5f\u80fd\u6b20\u640d\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u67af\u6e07\u75c7\u5019\u7fa4\u306e\u4e00\u578b\u3067\u3001\u7279\u306b\u809d\u81d3\u3068\u795e\u7d4c\u7cfb\u306b\u91cd\u7be4\u306a\u969c\u5bb3\u3092\u6765\u3059\u9032\u884c\u6027\u75be\u60a3\u3067\u3059\u3002\u672c\u75be\u60a3\u306f\u3001\u3082\u3068\u3082\u3068\u30ca\u30d0\u30db\u65cf\u306b\u591a\u767a\u3059\u308b\u3053\u3068\u304b\u3089\u3053\u306e\u540d\u79f0\u304c\u4ed8\u3051\u3089\u308c\u307e\u3057\u305f\u304c\u3001\u73fe\u5728\u3067\u306f\u4e16\u754c\u5404\u5730\u3067\u540c\u69d8\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

MPV17\u907a\u4f1d\u5b50\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u306e\u5b89\u5b9a\u6027\u7dad\u6301\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002\u3053\u306e\u6a5f\u80fd\u304c\u5931\u308f\u308c\u308b\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u304c\u6e1b\u5c11\u30fb\u6b20\u5931\u3057\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u304c\u8457\u3057\u304f\u4f4e\u4e0b\u3057\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u9700\u8981\u306e\u9ad8\u3044\u809d\u81d3\u3068\u795e\u7d4c\u7cfb\u304c\u9078\u629e\u7684\u306b\u969c\u5bb3\u3055\u308c\u307e\u3059\u3002(PMC)<\/p>\n\n\n\n

\u75ab\u5b66<\/strong><\/h2>\n\n\n\n

\u30ca\u30d0\u30db\u795e\u7d4c\u809d\u75c7\u306f\u6975\u3081\u3066\u7a00\u306a\u75be\u60a3\u3067\u3001\u6709\u75c5\u7387\u306f100\u4e07\u4eba\u306b1\u4eba\u672a\u6e80\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30ca\u30d0\u30db\u65cf\u3067\u306f\u5275\u59cb\u8005\u52b9\u679c\u306b\u3088\u308a\u6bd4\u8f03\u7684\u983b\u5ea6\u304c\u9ad8\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002(Orphanet)<\/p>\n\n\n\n

\u539f\u56e0<\/strong><\/h2>\n\n\n\n

\u672c\u75be\u60a3\u306fMPV17\u907a\u4f1d\u5b50\u306e\u4e21\u30a2\u30ec\u30eb\u75c5\u7684\u5909\u7570\u306b\u3088\u308a\u767a\u75c7\u3057\u307e\u3059\u3002MPV17\u907a\u4f1d\u5b50\u306f\u30d2\u30c82\u756a\u67d3\u8272\u4f53\uff082p23\uff09\u306b\u4f4d\u7f6e\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u306e\u8907\u88fd\u30fb\u7dad\u6301\u304c\u969c\u5bb3\u3055\u308c\u307e\u3059\u3002(\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af)<\/p>\n\n\n\n

\u907a\u4f1d\u5f62\u5f0f\u306f\u5e38\u67d3\u8272\u4f53\u52a3\u6027\u907a\u4f1d<\/a>\u3067\u3059\u3002<\/p>\n\n\n\n

\u75c7\u72b6<\/strong><\/h2>\n\n\n\n

\u809d\u81d3<\/strong><\/h3>\n\n\n\n
    \n
  • \u65b0\u751f\u5150\u671f\u307e\u305f\u306f\u4e73\u5150\u671f\u306e\u809d\u4e0d\u5168<\/li>\n\n\n\n
  • \u9ec4\u75b8<\/li>\n\n\n\n
  • \u809d\u816b\u5927<\/li>\n<\/ul>\n\n\n\n

    \u795e\u7d4c<\/strong><\/h3>\n\n\n\n
      \n
    • \u767a\u9054\u9045\u6ede<\/li>\n\n\n\n
    • \u7b4b\u7dca\u5f35\u4f4e\u4e0b<\/li>\n\n\n\n
    • \u672b\u68a2\u795e\u7d4c\u969c\u5bb3<\/li>\n<\/ul>\n\n\n\n

      \u305d\u306e\u4ed6<\/strong><\/h3>\n\n\n\n
        \n
      • \u4f4e\u8840\u7cd6<\/li>\n\n\n\n
      • \u4ee3\u8b1d\u6027\u30a2\u30b7\u30c9\u30fc\u30b7\u30b9<\/li>\n<\/ul>\n\n\n\n

        \u8a3a\u65ad<\/strong><\/h2>\n\n\n\n
          \n
        1. \u8840\u4e2d\u4e73\u9178\u9ad8\u5024<\/li>\n\n\n\n
        2. \u809d\u6a5f\u80fd\u7570\u5e38<\/li>\n\n\n\n
        3. \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u67af\u6e07<\/li>\n\n\n\n
        4. \u907a\u4f1d\u5b50\u8a3a\u65ad\uff08MPV17\u89e3\u6790\uff09(PMC)<\/li>\n<\/ol>\n\n\n\n

          \u6cbb\u7642<\/strong><\/h2>\n\n\n\n
            \n
          • \u809d\u4e0d\u5168\u7ba1\u7406<\/li>\n\n\n\n
          • \u6804\u990a\u7ba1\u7406<\/li>\n\n\n\n
          • \u611f\u67d3\u4e88\u9632<\/li>\n\n\n\n
          • \u4e00\u90e8\u3067\u809d\u79fb\u690d\u304c\u691c\u8a0e\u3055\u308c\u307e\u3059\u304c\u4e88\u5f8c\u306f\u614e\u91cd<\/li>\n<\/ul>\n\n\n\n

            \u53c2\u8003\u6587\u732e<\/strong><\/h2>\n\n\n\n

            Navajo Neurohepatopathy \u2014 GeneReviews, PubMed Central.(PMC)
            El-Hattab AW et al. MPV17-related hepatocerebral mitochondrial DNA depletion syndrome. Mol Genet Metab. 2012.(MGM)
            Navajo neurohepatopathy \u2014 Orphanet Rare Disease Database.(Orphanet)
            MPV17 \u2014 Malacards Gene\/Disease Database.(malacards.org)<\/p>\n","protected":false},"featured_media":0,"menu_order":0,"template":"page_gd.php","class_list":["post-122115","genetic-diseases","type-genetic-diseases","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/122115","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/genetic-diseases"}],"version-history":[{"count":2,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/122115\/revisions"}],"predecessor-version":[{"id":122117,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/122115\/revisions\/122117"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=122115"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}