{"id":122130,"date":"2026-01-08T18:24:22","date_gmt":"2026-01-08T09:24:22","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/?post_type=genetic-diseases&p=122130"},"modified":"2026-01-08T18:24:23","modified_gmt":"2026-01-08T09:24:23","slug":"odonto-onycho-dermal-dysplasia-schopf-schulz-passarge-syndrome-wnt10a","status":"publish","type":"genetic-diseases","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/genetic-diseases2\/odonto-onycho-dermal-dysplasia-schopf-schulz-passarge-syndrome-wnt10a\/","title":{"rendered":"\u30aa\u30c9\u30f3\u30c8\u30fb\u30aa\u30cb\u30fc\u30b3\u30fb\u76ae\u819a\u7570\u5f62\u6210\u75c7\u30fb\u201d\u30aa\u30c9\u30f3\u30c8\u30fb\u30aa\u30cb\u30fc\u30b3\u30fb\u76ae\u819a\u7570\u5f62\u6210\u75c7\u3001\u30b7\u30e7\u30d7\u30d5\u30fb\u30b7\u30e5\u30eb\u30c4\u30fb\u30d1\u30b5\u30fc\u30b8\u75c7\u5019\u7fa4"},"content":{"rendered":"\n

\u6982\u8981<\/strong><\/h2>\n\n\n\n

\u30aa\u30c9\u30f3\u30c8\u30fb\u30aa\u30cb\u30fc\u30b3\u30fb\u76ae\u819a\u7570\u5f62\u6210\u75c7\uff08Odonto-onycho-dermal dysplasia\uff1aOODD\uff09\u304a\u3088\u3073\u30b7\u30e7\u30d7\u30d5\u30fb\u30b7\u30e5\u30eb\u30c4\u30fb\u30d1\u30b5\u30fc\u30b8\u75c7\u5019\u7fa4\uff08Schopf-Schulz-Passarge Syndrome\uff1aSSPS\uff09\u306f\u3001\u6b6f\u3001\u722a\u3001\u76ae\u819a\u3001\u6bdb\u9aea\u3001\u6c57\u817a\u306a\u3069\u306e\u5916\u80da\u8449\u7531\u6765\u7d44\u7e54\u306e\u5f62\u6210\u7570\u5e38\u3092\u7279\u5fb4\u3068\u3059\u308b\u907a\u4f1d\u6027\u5916\u80da\u8449\u7570\u5f62\u6210\u75c7\u306e\u4e00\u7fa4\u3067\u3059\u3002\u3053\u308c\u3089\u306f\u540c\u4e00\u907a\u4f1d\u5b50\u3067\u3042\u308bWNT10A\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u3001\u81e8\u5e8a\u7684\u306b\u91cd\u306a\u308a\u5408\u3046\u9023\u7d9a\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u3068\u3057\u3066\u7406\u89e3\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

WNT10A\u306fWnt\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306b\u5c5e\u3059\u308b\u30ea\u30ac\u30f3\u30c9\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3001\u6b6f\u80da\u5f62\u6210\u3001\u6bdb\u5305\u5f62\u6210\u3001\u6c57\u817a\u767a\u9054\u3001\u76ae\u819a\u89d2\u5316\u5236\u5fa1\u306a\u3069\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u3053\u306e\u7d4c\u8def\u304c\u969c\u5bb3\u3055\u308c\u308b\u3053\u3068\u3067\u3001\u6b6f\u306e\u6b20\u640d\uff08\u7121\u6b6f\u75c7\u30fb\u4e4f\u6b6f\u75c7\uff09\u3001\u722a\u306e\u7570\u5f62\u6210\u3001\u76ae\u819a\u306e\u89d2\u5316\u7570\u5e38\u3001\u6bdb\u9aea\u306e\u4f4e\u5f62\u6210\u3001\u767a\u6c57\u969c\u5bb3\u306a\u3069\u304c\u751f\u3058\u307e\u3059\u3002(PMC)<\/p>\n\n\n\n

\u75ab\u5b66<\/strong><\/h2>\n\n\n\n

\u6b63\u78ba\u306a\u6709\u75c5\u7387\u306f\u4e0d\u660e\u3067\u3059\u304c\u3001WNT10A\u5909\u7570\u306f\u5916\u80da\u8449\u7570\u5f62\u6210\u75c7\u306e\u539f\u56e0\u3068\u3057\u3066\u6bd4\u8f03\u7684\u983b\u5ea6\u304c\u9ad8\u304f\u3001\u4e4f\u6b6f\u75c7\u60a3\u8005\u306e\u7d0420\u301c30\uff05\u3067WNT10A\u5909\u7570\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002OODD\u304a\u3088\u3073SSPS\u306f\u6975\u3081\u3066\u7a00\u306a\u8868\u73fe\u578b\u3067\u3059\u3002(Orphanet)<\/p>\n\n\n\n

\u539f\u56e0<\/strong><\/h2>\n\n\n\n

\u672c\u75be\u60a3\u306fWNT10A\u907a\u4f1d\u5b50\u306e\u4e21\u30a2\u30ec\u30eb\u75c5\u7684\u5909\u7570\u307e\u305f\u306f\u4e00\u90e8\u512a\u6027\u4f5c\u7528\u578b\u5909\u7570\u306b\u3088\u3063\u3066\u767a\u75c7\u3057\u307e\u3059\u3002WNT10A\u907a\u4f1d\u5b50\u306f\u30d2\u30c82\u756a\u67d3\u8272\u4f53\uff082q35\uff09\u306b\u4f4d\u7f6e\u3057\u3001\u5916\u80da\u8449\u7d44\u7e54\u306e\u5206\u5316\u30fb\u767a\u9054\u3092\u5236\u5fa1\u3057\u307e\u3059\u3002(\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af)<\/p>\n\n\n\n

\u907a\u4f1d\u5f62\u5f0f\u306f\u5e38\u67d3\u8272\u4f53\u52a3\u6027\u304c\u57fa\u672c\u3067\u3059\u304c\u3001\u8efd\u75c7\u4f8b\u3067\u306f\u512a\u6027\u907a\u4f1d\u69d8\u306e\u8868\u73fe\u578b\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u75c7\u72b6<\/strong><\/h2>\n\n\n\n

\u6b6f<\/strong><\/h3>\n\n\n\n
    \n
  • \u4e4f\u6b6f\u75c7\u3001\u7121\u6b6f\u75c7<\/li>\n\n\n\n
  • \u5186\u9310\u6b6f<\/li>\n<\/ul>\n\n\n\n

    \u722a<\/strong><\/h3>\n\n\n\n
      \n
    • \u722a\u7532\u4f4e\u5f62\u6210<\/li>\n\n\n\n
    • \u8106\u5f31\u722a<\/li>\n<\/ul>\n\n\n\n

      \u76ae\u819a<\/strong><\/h3>\n\n\n\n
        \n
      • \u638c\u8e60\u89d2\u5316\u75c7<\/li>\n\n\n\n
      • \u4e7e\u71e5\u76ae\u819a<\/li>\n\n\n\n
      • \u76ae\u8102\u817a\u56a2\u816b\uff08SSPS\u3067\u7279\u5fb4\u7684\uff09<\/li>\n<\/ul>\n\n\n\n

        \u6bdb\u9aea<\/strong><\/h3>\n\n\n\n
          \n
        • \u758e\u6bdb<\/li>\n\n\n\n
        • \u8131\u6bdb\u50be\u5411<\/li>\n<\/ul>\n\n\n\n

          \u6c57\u817a<\/strong><\/h3>\n\n\n\n
            \n
          • \u4f4e\u6c57\u75c7\u307e\u305f\u306f\u7121\u6c57\u75c7<\/li>\n<\/ul>\n\n\n\n

            \u8a3a\u65ad<\/strong><\/h2>\n\n\n\n
              \n
            1. \u81e8\u5e8a\u6240\u898b\uff08\u6b6f\u30fb\u722a\u30fb\u76ae\u819a\u7570\u5e38\uff09<\/li>\n\n\n\n
            2. \u6b6f\u79d1\u30ec\u30f3\u30c8\u30b2\u30f3<\/li>\n\n\n\n
            3. \u907a\u4f1d\u5b50\u8a3a\u65ad\uff08WNT10A\u89e3\u6790\uff09(PMC)<\/li>\n<\/ol>\n\n\n\n

              \u6cbb\u7642<\/strong><\/h2>\n\n\n\n
                \n
              • \u6b6f\u79d1\u88dc\u7db4\u6cbb\u7642<\/li>\n\n\n\n
              • \u76ae\u819a\u79d1\u7684\u89d2\u5316\u7ba1\u7406<\/li>\n\n\n\n
              • \u767a\u6c57\u969c\u5bb3\u3078\u306e\u74b0\u5883\u8abf\u6574<\/li>\n\n\n\n
              • \u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0<\/li>\n<\/ul>\n\n\n\n

                \u53c2\u8003\u6587\u732e<\/strong><\/h2>\n\n\n\n

                Odonto-onycho-dermal dysplasia \u2014 Orphanet Rare Disease Database.(Orphanet)
                Bohring A et al. WNT10A mutations cause ectodermal dysplasia. Am J Hum Genet. 2009.(AJHG)
                Schopf-Schulz-Passarge syndrome \u2014 GeneReviews, PubMed Central.(PMC)
                WNT10A \u2014 Malacards Gene\/Disease Database.(malacards.org)<\/p>\n","protected":false},"featured_media":0,"menu_order":0,"template":"page_gd.php","class_list":["post-122130","genetic-diseases","type-genetic-diseases","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/122130","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/genetic-diseases"}],"version-history":[{"count":1,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/122130\/revisions"}],"predecessor-version":[{"id":122131,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/122130\/revisions\/122131"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=122130"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}