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class=\"wp-block-paragraph\">\u78ba\u5b9a\u8a3a\u65ad\u306f<strong>\u907a\u4f1d\u5b66\u7684\u691c\u67fb<\/strong>\u3067\u884c\u3044\u30014\u578b\u3067\u306f <strong>HADH<\/strong> \u907a\u4f1d\u5b50\u306b\u7236\u65b9\u30fb\u6bcd\u65b9\u305d\u308c\u305e\u308c\u7531\u6765\u306e\u5909\u5316\u304c\u898b\u3064\u304b\u308a\u307e\u3059\u3002<strong>\u539f\u56e0\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u85ac\u306e\u52b9\u304d\u3084\u3059\u3055\u3001\u624b\u8853\u304c\u5fc5\u8981\u304b\u3069\u3046\u304b\u3001\u6b21\u306e\u304a\u5b50\u3055\u307e\u306e\u898b\u901a\u3057\u304c\u5909\u308f\u308b\u305f\u3081\u3001\u539f\u56e0\u907a\u4f1d\u5b50\u3092\u78ba\u5b9a\u3059\u308b\u3053\u3068\u306b\u306f\u5927\u304d\u306a\u610f\u5473\u304c\u3042\u308a\u307e\u3059\u3002<\/strong><\/p>\n\n\n<h2 class=\"wp-block-heading\">\u6cbb\u7642<\/h2>\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6cbb\u7642\u306e\u76ee\u6a19\u306f\u3001\u4f4e\u8840\u7cd6\u3092\u9632\u3044\u3067\u8133\u3092\u5b88\u308b\u3053\u3068\u3067\u3059\u3002<\/strong>\u3053\u306e\u578b\u3067\u306f<strong>\u30b8\u30a2\u30be\u30ad\u30b7\u30c9\u3068\u3044\u3046\u98f2\u307f\u85ac\u304c\u3088\u304f\u52b9\u304f\u3053\u3068\u304c\u591a\u3044<\/strong>\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u52b9\u304d\u65b9\u3084\u526f\u4f5c\u7528\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308b\u305f\u3081\u3001\u5c02\u9580\u306e\u533b\u5e2b\u306e\u3082\u3068\u3067\u91cf\u3092\u8abf\u6574\u3057\u307e\u3059\u3002<\/p>\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4f4e\u8840\u7cd6\u304c\u8d77\u304d\u305f\u3068\u304d\u306e\u5bfe\u5fdc<\/strong>\uff1a\u30d6\u30c9\u30a6\u7cd6\u306e\u70b9\u6ef4\u3084\u30b0\u30eb\u30ab\u30b4\u30f3\u306e\u6ce8\u5c04\u3067\u8840\u7cd6\u3092\u4e0a\u3052\u307e\u3059<\/li>\n\n\n\n<li><strong>\u30b8\u30a2\u30be\u30ad\u30b7\u30c9<\/strong>\uff1a\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u5206\u6ccc\u3092\u6291\u3048\u308b\u98f2\u307f\u85ac\u3067\u3059\u3002\u3080\u304f\u307f\u3084\u6bdb\u6df1\u304f\u306a\u308b\u306a\u3069\u306e\u526f\u4f5c\u7528\u306b\u6ce8\u610f\u3057\u306a\u304c\u3089\u4f7f\u3044\u307e\u3059<\/li>\n\n\n\n<li><strong>\u98df\u4e8b\u306e\u5de5\u592b<\/strong>\uff1a\u7a7a\u8179\u306e\u6642\u9593\u3092\u9577\u304f\u3057\u306a\u3044\u3053\u3068\u3001\u305f\u3093\u3071\u304f\u8cea\u306e\u591a\u3044\u98df\u4e8b\u306e\u3068\u308a\u65b9\u306a\u3069\u3092\u3001\u533b\u5e2b\u30fb\u6804\u990a\u58eb\u3068\u76f8\u8ac7\u3057\u307e\u3059<\/li>\n\n\n\n<li><strong>\u3054\u5bb6\u5ead\u3067\u306e\u8840\u7cd6\u6e2c\u5b9a<\/strong>\uff1a\u4f53\u8abf\u3092\u5d29\u3057\u305f\u3068\u304d\u3084\u98df\u4e8b\u304c\u5341\u5206\u306b\u3068\u308c\u306a\u3044\u3068\u304d\u306e\u5bfe\u5fdc\u3092\u3001\u3042\u3089\u304b\u3058\u3081\u6c7a\u3081\u3066\u304a\u304d\u307e\u3059<\/li>\n\n\n\n<li><strong>\u767a\u9054\u306e\u5b9a\u671f\u7684\u306a\u78ba\u8a8d<\/strong>\uff1a\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u7642\u80b2\u3084\u30ea\u30cf\u30d3\u30ea\u30c6\u30fc\u30b7\u30e7\u30f3\u306e\u652f\u63f4\u3092\u53d7\u3051\u307e\u3059<\/li>\n\n\n<\/ul>\n\n\n<h2 class=\"wp-block-heading\">\u3053\u306e\u75be\u60a3\u306f\u691c\u67fb\u3067\u308f\u304b\u308a\u307e\u3059<\/h2>\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u75be\u60a3\u306f\u3001\u539f\u56e0\u3068\u306a\u308b <strong>HADH<\/strong> \u907a\u4f1d\u5b50\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3001\u767a\u75c7\u524d\u3084\u51fa\u751f\u524d\u306b\u898b\u3064\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30afNIPT\u3067\u306f\u6b21\u306e\u691c\u67fb\u3092\u3054\u7528\u610f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">\u30a8\u30af\u30bd\u30fc\u30e0\u89e3\u6790\u3092\u7528\u3044\u305f\u691c\u67fb\uff081,200\u7a2e\u985e\u4ee5\u4e0a\uff09<\/h3>\n\n\n<p class=\"wp-block-paragraph\">\u30a8\u30af\u30bd\u30fc\u30e0\u89e3\u6790\u306f\u3001\u907a\u4f1d\u5b50\u306e\u3046\u3061\u305f\u3093\u3071\u304f\u8cea\u306e\u8a2d\u8a08\u56f3\u306b\u3042\u305f\u308b\u90e8\u5206\uff08\u30a8\u30af\u30bd\u30f3\uff09\u3092\u307e\u3068\u3081\u3066\u8aad\u307f\u53d6\u308b\u691c\u67fb\u3067\u3059\u3002\u3053\u306e\u89e3\u6790\u3092\u884c\u3063\u305f\u3046\u3048\u3067\u3001<strong>HADH<\/strong> \u907a\u4f1d\u5b50\u3092\u542b\u3080<strong>1,200\u7a2e\u985e\u4ee5\u4e0a<\/strong>\u306e\u907a\u4f1d\u5b50\u3092\u5bfe\u8c61\u306b\u8abf\u3079\u3001<strong>\u3053\u306e\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u308b\u5909\u5316\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059<\/strong>\u3002\u56fd\u5185\u306e\u691c\u67fb\u6240\u3067\u884c\u3044\u3001\u7d50\u679c\u307e\u3067\u306e\u671f\u9593\u306f5\u9031\u9593\u301c7\u9031\u9593\u3067\u3059\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\">\u5e38\u67d3\u8272\u4f53\u6f5c\u6027\uff08\u52a3\u6027\uff09\u907a\u4f1d\u306e\u75be\u60a3\u306f\u3001\u3054\u4e21\u89aa\u304c\u3069\u3061\u3089\u3082\u75c7\u72b6\u306e\u306a\u3044\u300c\u30ad\u30e3\u30ea\u30a2\uff08\u4fdd\u56e0\u8005\uff09\u300d\u3067\u3042\u308b\u3068\u304d\u306b\u3001<strong>4\u5206\u306e1\u306e\u78ba\u7387<\/strong>\u3067\u304a\u5b50\u3055\u307e\u304c\u767a\u75c7\u3057\u307e\u3059\u3002\u691c\u67fb\u306e\u5185\u5bb9\u30fb\u8cbb\u7528\u30fb\u7d50\u679c\u307e\u3067\u306e\u671f\u9593\u306f <a href=\"\/nipt\/nipt\/carrier-screening-1200\/\">\u30ad\u30e3\u30ea\u30a2\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30c6\u30b9\u30c81,200\uff0b\u306e\u30da\u30fc\u30b8<\/a> \u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n<h2 class=\"wp-block-heading\">\u5c02\u9580\u7684\u306a\u89e3\u8aac<\/h2>\n\n\n<p class=\"wp-block-paragraph\"><strong>HADH<\/strong> \u306f<strong>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u03b2\u9178\u5316\u306e\u77ed\u93963-\u30d2\u30c9\u30ed\u30ad\u30b7\u30a2\u30b7\u30ebCoA\u8131\u6c34\u7d20\u9175\u7d20\uff08SCHAD\uff09<\/strong>\u3092\u30b3\u30fc\u30c9\u3057\u3001\u81b5\u03b2\u7d30\u80de\u3067\u9ad8\u767a\u73fe\u3059\u308b\u3002SCHAD \u6b20\u640d\u75c7\u306f\u8102\u80aa\u9178\u9178\u5316\u7570\u5e38\u75c7\u306b\u5206\u985e\u3055\u308c\u308b\u304c\u3001<strong>\u4e3b\u306a\u81e8\u5e8a\u50cf\u306f\u4f4e\u30b1\u30c8\u30f3\u6027\u306e\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u6027\u4f4e\u8840\u7cd6\u3067\u3042\u308a\u3001\u5fc3\u7b4b\u75c7\u30fb\u9aa8\u683c\u7b4b\u75c7\u72b6\u30fb\u809d\u969c\u5bb3\u3092\u4f34\u3046\u3053\u3068\u306f\u4e00\u822c\u7684\u3067\u306a\u3044<\/strong>\u70b9\u3067\u3001\u307b\u304b\u306e\u03b2\u9178\u5316\u7570\u5e38\u75c7\u3068\u7570\u306a\u308b\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\">\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7\u306e\u6a5f\u5e8f\u306f\u03b2\u9178\u5316\u969c\u5bb3\u305d\u306e\u3082\u306e\u3067\u306f\u306a\u304f\u3001<strong>SCHAD \u3068\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u8131\u6c34\u7d20\u9175\u7d20\uff08GDH\uff09\u306e\u305f\u3093\u3071\u304f\u8cea\u9593\u76f8\u4e92\u4f5c\u7528\u306e\u6d88\u5931<\/strong>\u306b\u3088\u308b\u3002SCHAD \u306f GDH \u3092\u6291\u5236\u7684\u306b\u5236\u5fa1\u3057\u3066\u304a\u308a\u3001\u6b20\u640d\u3059\u308b\u3068<strong>GDH \u6d3b\u6027\u304c\u4ea2\u9032\u3057\u3001\u30ed\u30a4\u30b7\u30f3\u523a\u6fc0\u306b\u3088\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u304c\u904e\u5270<\/strong>\u306b\u306a\u308b\u3002\u3053\u306e\u305f\u3081\u3001<strong>GLUD1 \u6d3b\u6027\u5316\u5909\u7570\u306b\u3088\u308b\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7\u30fb\u9ad8\u30a2\u30f3\u30e2\u30cb\u30a2\u8840\u75c7\u75c7\u5019\u7fa4\uff086\u578b\uff09\u3068\u540c\u69d8\u306b\u305f\u3093\u3071\u304f\u8cea\u8a98\u767a\u6027\u4f4e\u8840\u7cd6\u3092\u793a\u3059\u304c\u30014\u578b\u3067\u306f\u9ad8\u30a2\u30f3\u30e2\u30cb\u30a2\u8840\u75c7\u3092\u4f34\u308f\u306a\u3044<\/strong>\u70b9\u304c\u9451\u5225\u306b\u5f79\u7acb\u3064\u3002\u751f\u5316\u5b66\u7684\u306b\u306f<strong>\u8840\u6f3f3-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d6\u30c1\u30ea\u30eb\u30ab\u30eb\u30cb\u30c1\u30f3\uff08C4-OH\uff09\u3068\u5c3f\u4e2d3-\u30d2\u30c9\u30ed\u30ad\u30b7\u30b0\u30eb\u30bf\u30eb\u9178\u306e\u4e0a\u6607<\/strong>\u304c\u624b\u304c\u304b\u308a\u3068\u306a\u308b\u304c\u3001\u6b63\u5e38\u7bc4\u56f2\u306e\u4f8b\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\">\u9451\u5225\u3068\u3057\u3066\u306f\u30011\u578b\uff08<em>ABCC8<\/em>\uff09\u30fb2\u578b\uff08<em>KCNJ11<\/em>\uff09\u306e KATP \u30c1\u30e3\u30cd\u30eb\u7570\u5e38\u75c7\uff08\u30b8\u30a2\u30be\u30ad\u30b7\u30c9\u4e0d\u5fdc\u4f8b\u304c\u591a\u304f\u3001\u5c40\u6240\u578b\u3067\u306f\u81b5\u90e8\u5206\u5207\u9664\u304c\u6839\u6cbb\u7684\u3068\u306a\u308b\uff09\u30013\u578b\uff08<em>GCK<\/em>\u3001\u9855\u6027\uff09\u30016\u578b\uff08<em>GLUD1<\/em>\u3001\u9855\u6027\uff09\u30017\u578b\uff08<em>SLC16A1<\/em>\u3001\u904b\u52d5\u8a98\u767a\u6027\uff09\u304c\u6319\u304c\u308b\u3002<strong>HADH \u5909\u7570\u306f\u3001\u8840\u65cf\u5a5a\u306e\u591a\u3044\u96c6\u56e3\u3067\u30b8\u30a2\u30be\u30ad\u30b7\u30c9\u53cd\u5fdc\u6027\u306e\u6301\u7d9a\u6027\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7\u306e\u539f\u56e0\u3068\u3057\u3066\u6bd4\u8f03\u7684\u591a\u304f\u540c\u5b9a\u3055\u308c\u3066\u304a\u308a\u3001\u75c5\u5909\u306f\u81b5\u5168\u4f53\u306b\u53ca\u3076\u3073\u307e\u3093\u6027\u3067\u3042\u308b\u3002<\/strong>\u907a\u4f1d\u5f62\u5f0f\u3068\u6cbb\u7642\u53cd\u5fdc\u6027\u304c\u578b\u3054\u3068\u306b\u7570\u306a\u308b\u305f\u3081\u3001<strong>\u907a\u4f1d\u5b50\u8a3a\u65ad\u306f\u6cbb\u7642\u65b9\u91dd\u3068\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306b\u76f4\u7d50\u3059\u308b\u3002<\/strong><\/p>\n\n\n<h2 class=\"wp-block-heading\">\u3088\u304f\u3042\u308b\u8cea\u554f<\/h2>\n\n\n<h3 class=\"wp-block-heading\">Q. \u6b21\u306e\u304a\u5b50\u3055\u307e\u3078\u306e\u5f71\u97ff\u306f\u3042\u308a\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u3053\u306e\u75c5\u6c17\u306f\u5e38\u67d3\u8272\u4f53\u6f5c\u6027\u907a\u4f1d\u306e\u305f\u3081\u3001\u3054\u4e21\u89aa\u304c\u3069\u3061\u3089\u3082\u30ad\u30e3\u30ea\u30a2\u306e\u5834\u5408\u3001\u304a\u5b50\u3055\u307e\u3054\u3068\u306b4\u5206\u306e1\u306e\u78ba\u7387\u3067\u767a\u75c7\u3057\u307e\u3059\u3002<\/strong>\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7\u306b\u306f\u9855\u6027\u907a\u4f1d\u306e\u578b\u3084\u3001\u5076\u767a\u7684\u306b\u8d77\u3053\u308b\u3082\u306e\u3082\u3042\u308a\u3001\u578b\u306b\u3088\u3063\u3066\u518d\u767a\u7387\u304c\u7570\u306a\u308a\u307e\u3059\u3002<strong>\u539f\u56e0\u907a\u4f1d\u5b50\u3092\u78ba\u5b9a\u3059\u308b\u3053\u3068\u304c\u3001\u6b63\u78ba\u306a\u898b\u901a\u3057\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/strong><\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u598a\u5a20\u4e2d\u306b\u5206\u304b\u308a\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u3053\u306e\u75c5\u6c17\u306f\u598a\u5a20\u4e2d\u306e\u8d85\u97f3\u6ce2\u691c\u67fb\u3067\u306f\u898b\u3064\u3051\u306b\u304f\u304f\u3001\u591a\u304f\u306f\u751f\u307e\u308c\u305f\u3042\u3068\u306e\u4f4e\u8840\u7cd6\u3067\u6c17\u3065\u304b\u308c\u307e\u3059\u3002<\/strong>\u524d\u306e\u304a\u5b50\u3055\u307e\u3067\u539f\u56e0\u907a\u4f1d\u5b50\u304c\u5206\u304b\u3063\u3066\u3044\u308b\u5834\u5408\u306f\u3001\u51fa\u751f\u524d\u306e\u907a\u4f1d\u5b66\u7684\u691c\u67fb\u3092\u691c\u8a0e\u3067\u304d\u307e\u3059\u3002\u307e\u305f\u3001<strong>\u3042\u3089\u304b\u3058\u3081\u5206\u304b\u3063\u3066\u3044\u308c\u3070\u3001\u751f\u307e\u308c\u3066\u3059\u3050\u304b\u3089\u8840\u7cd6\u3092\u78ba\u8a8d\u3057\u3001\u4f4e\u8840\u7cd6\u3092\u65e9\u304f\u9632\u3050\u6e96\u5099\u304c\u3067\u304d\u307e\u3059\u3002<\/strong><\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u307b\u304b\u306e\u578b\u3068\u306f\u3069\u3046\u9055\u3044\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>4\u578b\u306f HADH \u907a\u4f1d\u5b50\u304c\u539f\u56e0\u3067\u3001\u305f\u3093\u3071\u304f\u8cea\u306e\u591a\u3044\u98df\u4e8b\u306e\u3042\u3068\u306b\u4f4e\u8840\u7cd6\u304c\u8d77\u3053\u308a\u3084\u3059\u304f\u3001\u98f2\u307f\u85ac\uff08\u30b8\u30a2\u30be\u30ad\u30b7\u30c9\uff09\u304c\u52b9\u304d\u3084\u3059\u3044\u3053\u3068\u304c\u7279\u5fb4\u3067\u3059\u3002<\/strong>\u3082\u3063\u3068\u3082\u591a\u30441\u578b\u30fb2\u578b\u3067\u306f\u85ac\u304c\u52b9\u304b\u305a\u306b\u81b5\u81d3\u306e\u624b\u8853\u304c\u5fc5\u8981\u306b\u306a\u308b\u5834\u5408\u304c\u3042\u308a\u30016\u578b\u3067\u306f\u8840\u6db2\u4e2d\u306e\u30a2\u30f3\u30e2\u30cb\u30a2\u3082\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u5927\u304d\u304f\u306a\u308c\u3070\u6cbb\u308a\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u6210\u9577\u3068\u3068\u3082\u306b\u4f4e\u8840\u7cd6\u304c\u8d77\u3053\u308a\u306b\u304f\u304f\u306a\u308a\u3001\u85ac\u3092\u6e1b\u3089\u305b\u308b\u65b9\u3082\u3044\u307e\u3059\u304c\u3001\u7d4c\u904e\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u307e\u3059\u3002<\/strong>\u6cbb\u7642\u3092\u7d9a\u3051\u3066\u3044\u308b\u3042\u3044\u3060\u3082\u3001\u6210\u9577\u306b\u5408\u308f\u305b\u3066\u85ac\u306e\u91cf\u3084\u98df\u4e8b\u3092\u898b\u76f4\u3057\u3066\u3044\u304d\u307e\u3059\u3002<strong>\u4f4e\u8840\u7cd6\u3092\u304f\u308a\u8fd4\u3055\u306a\u3044\u3088\u3046\u7ba1\u7406\u3092\u7d9a\u3051\u308b\u3053\u3068\u304c\u3001\u5c06\u6765\u306e\u767a\u9054\u3092\u5b88\u308b\u3053\u3068\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/strong><\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067\u306f\u4f55\u3092\u76f8\u8ac7\u3067\u304d\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. \u8a3a\u65ad\u306e\u610f\u5473\u3001\u6b21\u306e\u304a\u5b50\u3055\u307e\u3078\u306e\u5f71\u97ff\u3001\u51fa\u751f\u524d\u691c\u67fb\u3084\u7740\u5e8a\u524d\u691c\u67fb\u306e\u9078\u629e\u80a2\u3001\u3054\u304d\u3087\u3046\u3060\u3044\u3084\u3054\u89aa\u65cf\u3078\u306e\u5f71\u97ff\u306a\u3069\u3092\u3054\u76f8\u8ac7\u3044\u305f\u3060\u3051\u307e\u3059\u3002\u5224\u65ad\u3092\u6025\u304c\u305b\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n<h2 class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e<\/h2>\n\n\n<ul class=\"wp-block-list\">\n<li>Clayton PT, Eaton S, Aynsley-Green A, et al. Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion. <em>J Clin Invest<\/em>. 2001;108(3):457-465.<\/li>\n\n\n\n<li>Molven A, Matre GE, Duran M, et al. Familial hyperinsulinemic hypoglycemia caused by a defect in the SCHAD enzyme of mitochondrial fatty acid oxidation. <em>Diabetes<\/em>. 2004;53(1):221-227.<\/li>\n\n\n\n<li>Flanagan SE, Patch AM, Locke JM, et al. Genome-wide homozygosity analysis reveals HADH mutations as a common cause of diazoxide-responsive hyperinsulinemic-hypoglycemia in consanguineous pedigrees. <em>J Clin Endocrinol Metab<\/em>. 2011;96(3):E498-E502.<\/li>\n\n\n\n<li>Thornton PS, Stanley CA, De Leon DD, et al. Recommendations from the Pediatric Endocrine Society for evaluation and management of persistent hypoglycemia in neonates, infants, and children. <em>J Pediatr<\/em>. 2015;167(2):238-245.<\/li>\n\n\n\n<li>OMIM #609975 Hyperinsulinemic hypoglycemia, familial, 4; HHF4. Online Mendelian Inheritance in Man.<\/li>\n\n\n<\/ul>\n","protected":false},"featured_media":0,"menu_order":0,"template":"page_gd.php","class_list":["post-147377","genetic-diseases","type-genetic-diseases","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/147377","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/genetic-diseases"}],"version-history":[{"count":0,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/147377\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=147377"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}