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IgE \u304c\u975e\u5e38\u306b\u9ad8\u304f\u306a\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059<\/li>\n\n\n\n<li><strong>\u5f37\u3044\u304b\u3086\u307f<\/strong>\uff1a\u7720\u308a\u3084\u751f\u6d3b\u306e\u8cea\u306b\u5927\u304d\u304f\u5f71\u97ff\u3057\u307e\u3059<\/li>\n\n\n\n<li>\u76ae\u819a\u306e\u611f\u67d3\u75c7\u3092\u7e70\u308a\u8fd4\u3057\u3084\u3059\u304f\u3001\u6210\u4eba\u671f\u306b\u306f<strong>\u76ae\u819a\u304c\u3093\uff08\u6709\u68d8\u7d30\u80de\u764c\uff09\u304c\u82e5\u3044\u3046\u3061\u304b\u3089\u8d77\u3053\u308b<\/strong>\u3068\u306e\u5831\u544a\u304c\u3042\u308a\u307e\u3059<\/li>\n\n\n<\/ul>\n\n\n<h2 class=\"wp-block-heading\">\u691c\u67fb\u30fb\u8a3a\u65ad<\/h2>\n\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u307e\u308c\u305f\u3068\u304d\u304b\u3089\u306e\u5168\u8eab\u306e\u8d64\u307f\u3068\u76ae\u3080\u3051\u3001\u9aea\u306e\u7570\u5e38\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75c7\u72b6\u306e\u7d44\u307f\u5408\u308f\u305b<\/strong>\u304b\u3089\u7591\u308f\u308c\u307e\u3059\u3002\u9aea\u306e\u6bdb\u3084\u7709\u6bdb\u3092\u9855\u5fae\u93e1\u3067\u8abf\u3079\u3066<strong>\u7af9\u7bc0\u72b6\u6bdb\u304c\u898b\u3064\u304b\u308c\u3070\u3001\u8a3a\u65ad\u306e\u5927\u304d\u306a\u624b\u304c\u304b\u308a<\/strong>\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u4e73\u5150\u671f\u306b\u306f\u306f\u3063\u304d\u308a\u3057\u306a\u3044\u3053\u3068\u3082\u3042\u308a\u3001\u7e70\u308a\u8fd4\u3057\u8abf\u3079\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u76ae\u819a\u306e\u4e00\u90e8\u3092\u3068\u3063\u3066\u3001<strong>LEKTI \u305f\u3093\u3071\u304f\u8cea\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u3092\u7279\u6b8a\u306a\u67d3\u8272\u3067\u8abf\u3079\u308b\u691c\u67fb<\/strong>\u3082\u6709\u7528\u3067\u3059\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\">\u78ba\u5b9a\u8a3a\u65ad\u306f<strong>\u907a\u4f1d\u5b66\u7684\u691c\u67fb<\/strong>\u3067\u884c\u3044\u3001<strong>SPINK5<\/strong> \u907a\u4f1d\u5b50\u306b\u7236\u65b9\u30fb\u6bcd\u65b9\u305d\u308c\u305e\u308c\u7531\u6765\u306e\u5909\u5316\u304c\u898b\u3064\u304b\u308a\u307e\u3059\u3002<strong>\u598a\u5a20\u4e2d\u306e\u8d85\u97f3\u6ce2\u691c\u67fb\u3067\u306f\u3001\u3075\u3064\u3046\u7570\u5e38\u306f\u898b\u3064\u304b\u308a\u307e\u305b\u3093\u3002<\/strong>\u305d\u306e\u305f\u3081\u3001\u524d\u306e\u304a\u5b50\u3055\u307e\u3067\u539f\u56e0\u3068\u306a\u308b\u907a\u4f1d\u5b50\u306e\u5909\u5316\u304c\u308f\u304b\u3063\u3066\u3044\u308b\u5834\u5408\u306b\u3001\u305d\u306e\u5909\u5316\u3092\u8abf\u3079\u308b\u65b9\u6cd5\u3067<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n<h2 class=\"wp-block-heading\">\u6cbb\u7642<\/h2>\n\n\n<p class=\"wp-block-paragraph\"><strong>\u73fe\u6642\u70b9\u3067\u3001\u3053\u306e\u75c5\u6c17\u3092\u6839\u672c\u304b\u3089\u6cbb\u3059\u6cbb\u7642\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/strong>\u76ae\u819a\u3092\u5b88\u308a\u3001\u5408\u4f75\u75c7\u3092\u9632\u304e\u3001\u304b\u3086\u307f\u3084\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u3084\u308f\u3089\u3052\u308b\u6cbb\u7642\u304c\u4e2d\u5fc3\u3067\u3059\u3002<strong>\u3068\u304f\u306b\u65b0\u751f\u5150\u671f\u306f\u3001\u76ae\u819a\u79d1\u30fb\u5c0f\u5150\u79d1\u30fb\u65b0\u751f\u5150\u79d1\u304c\u9023\u643a\u3057\u3066\u614e\u91cd\u306b\u7ba1\u7406\u3059\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/strong><\/p>\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u65b0\u751f\u5150\u671f\u306e\u96c6\u4e2d\u7684\u306a\u7ba1\u7406<\/strong>\uff1a\u6e7f\u5ea6\u3092\u4fdd\u3063\u305f\u4fdd\u80b2\u5668\u3067\u306e\u7ba1\u7406\u3001\u6c34\u5206\u30fb\u5869\u5206\uff08\u96fb\u89e3\u8cea\uff09\u306e\u88dc\u6b63\u3001\u6804\u990a\u306e\u88dc\u7d66\u3001\u611f\u67d3\u306e\u4e88\u9632\u3068\u65e9\u671f\u6cbb\u7642\u3092\u884c\u3044\u307e\u3059<\/li>\n\n\n\n<li><strong>\u6bce\u65e5\u306e\u30b9\u30ad\u30f3\u30b1\u30a2<\/strong>\uff1a\u4fdd\u6e7f\u5264\u3092\u3053\u307e\u3081\u306b\u5857\u308a\u3001\u523a\u6fc0\u306e\u5c11\u306a\u3044\u5165\u6d74\u3067\u76ae\u819a\u3092\u6e05\u6f54\u306b\u4fdd\u3061\u307e\u3059<\/li>\n\n\n\n<li><strong>\u5857\u308a\u85ac\u306f\u614e\u91cd\u306b<\/strong>\uff1a<strong>\u76ae\u819a\u306e\u30d0\u30ea\u30a2\u304c\u5f31\u304f\u3001\u5857\u308a\u85ac\u304c\u4f53\u306e\u4e2d\u306b\u5438\u53ce\u3055\u308c\u3084\u3059\u3044\u305f\u3081<\/strong>\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u3084\u514d\u75ab\u3092\u6291\u3048\u308b\u5857\u308a\u85ac\u306f\u3001\u7bc4\u56f2\u3084\u91cf\u306b\u6ce8\u610f\u3057\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u8840\u6db2\u4e2d\u306e\u6fc3\u5ea6\u3092\u78ba\u8a8d\u3057\u306a\u304c\u3089\u4f7f\u3044\u307e\u3059<\/li>\n\n\n\n<li><strong>\u304b\u3086\u307f\u3068\u30a2\u30ec\u30eb\u30ae\u30fc\u3078\u306e\u5bfe\u5fdc<\/strong>\uff1a\u304b\u3086\u307f\u6b62\u3081\u306e\u98f2\u307f\u85ac\u3001\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u8a3a\u65ad\u3068\u98df\u4e8b\u306e\u8abf\u6574\u3001\u5598\u606f\u306e\u6cbb\u7642\u306a\u3069\u3092\u884c\u3044\u307e\u3059<\/li>\n\n\n\n<li><strong>\u91cd\u3044\u5834\u5408\u306e\u8ffd\u52a0\u6cbb\u7642<\/strong>\uff1a\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u88fd\u5264\u306e\u88dc\u5145\u3084\u3001\u708e\u75c7\u306b\u304b\u304b\u308f\u308b\u7269\u8cea\u3092\u6291\u3048\u308b\u6ce8\u5c04\u85ac\uff08\u751f\u7269\u5b66\u7684\u88fd\u5264\uff09\u3067\u6539\u5584\u3057\u305f\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u307e\u3060\u7814\u7a76\u6bb5\u968e\u306e\u3082\u306e\u3082\u591a\u304f\u3001\u52b9\u679c\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u307e\u3059<\/li>\n\n\n\n<li><strong>\u5b9a\u671f\u7684\u306a\u76ae\u819a\u306e\u8a3a\u5bdf<\/strong>\uff1a\u611f\u67d3\u75c7\u3084\u76ae\u819a\u304c\u3093\u306e\u65e9\u671f\u767a\u898b\u306e\u305f\u3081\u306b\u7d9a\u3051\u307e\u3059<\/li>\n\n\n\n<li><strong>\u3054\u672c\u4eba\u30fb\u3054\u5bb6\u65cf\u3078\u306e\u5fc3\u7406\u7684\u30fb\u793e\u4f1a\u7684\u652f\u63f4<\/strong>\uff1a\u898b\u305f\u76ee\u306e\u60a9\u307f\u3084\u6bce\u65e5\u306e\u30b1\u30a2\u306e\u8ca0\u62c5\u306b\u5bc4\u308a\u6dfb\u3046\u652f\u63f4\u304c\u5927\u5207\u3067\u3059<\/li>\n\n\n<\/ul>\n\n\n<h2 class=\"wp-block-heading\">\u3053\u306e\u75be\u60a3\u306f\u691c\u67fb\u3067\u308f\u304b\u308a\u307e\u3059<\/h2>\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u75be\u60a3\u306f\u3001\u539f\u56e0\u3068\u306a\u308b <strong>SPINK5<\/strong> \u907a\u4f1d\u5b50\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3001\u767a\u75c7\u524d\u3084\u51fa\u751f\u524d\u306b\u898b\u3064\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30afNIPT\u3067\u306f\u6b21\u306e\u691c\u67fb\u3092\u3054\u7528\u610f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">\u30a8\u30af\u30bd\u30fc\u30e0\u89e3\u6790\u3092\u7528\u3044\u305f\u691c\u67fb\uff081,200\u7a2e\u985e\u4ee5\u4e0a\uff09<\/h3>\n\n\n<p class=\"wp-block-paragraph\">\u30a8\u30af\u30bd\u30fc\u30e0\u89e3\u6790\u306f\u3001\u907a\u4f1d\u5b50\u306e\u3046\u3061\u305f\u3093\u3071\u304f\u8cea\u306e\u8a2d\u8a08\u56f3\u306b\u3042\u305f\u308b\u90e8\u5206\uff08\u30a8\u30af\u30bd\u30f3\uff09\u3092\u307e\u3068\u3081\u3066\u8aad\u307f\u53d6\u308b\u691c\u67fb\u3067\u3059\u3002\u3053\u306e\u89e3\u6790\u3092\u884c\u3063\u305f\u3046\u3048\u3067\u3001<strong>SPINK5<\/strong> \u907a\u4f1d\u5b50\u3092\u542b\u3080<strong>1,200\u7a2e\u985e\u4ee5\u4e0a<\/strong>\u306e\u907a\u4f1d\u5b50\u3092\u5bfe\u8c61\u306b\u8abf\u3079\u3001<strong>\u3053\u306e\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u308b\u5909\u5316\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059<\/strong>\u3002\u56fd\u5185\u306e\u691c\u67fb\u6240\u3067\u884c\u3044\u3001\u7d50\u679c\u307e\u3067\u306e\u671f\u9593\u306f5\u9031\u9593\u301c7\u9031\u9593\u3067\u3059\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\">\u5e38\u67d3\u8272\u4f53\u6f5c\u6027\uff08\u52a3\u6027\uff09\u907a\u4f1d\u306e\u75be\u60a3\u306f\u3001\u3054\u4e21\u89aa\u304c\u3069\u3061\u3089\u3082\u75c7\u72b6\u306e\u306a\u3044\u300c\u30ad\u30e3\u30ea\u30a2\uff08\u4fdd\u56e0\u8005\uff09\u300d\u3067\u3042\u308b\u3068\u304d\u306b\u3001<strong>\u304a\u5b50\u3055\u307e\u3054\u3068\u306b4\u5206\u306e1\u306e\u78ba\u7387<\/strong>\u3067\u767a\u75c7\u3057\u307e\u3059\u3002\u306a\u304a\u3001\u3053\u306e\u75be\u60a3\u306f228\u7a2e\u985e\u306e\u30ad\u30e3\u30ea\u30a2\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30c6\u30b9\u30c8\u306e\u5bfe\u8c61\u306b\u306f\u542b\u307e\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u691c\u67fb\u306e\u5185\u5bb9\u30fb\u8cbb\u7528\u30fb\u7d50\u679c\u307e\u3067\u306e\u671f\u9593\u306f <a href=\"\/nipt\/nipt\/carrier-screening-1200\/\">\u30ad\u30e3\u30ea\u30a2\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30c6\u30b9\u30c81,200\uff0b\u306e\u30da\u30fc\u30b8<\/a> \u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n<h2 class=\"wp-block-heading\">\u5c02\u9580\u7684\u306a\u89e3\u8aac<\/h2>\n\n\n<p class=\"wp-block-paragraph\"><strong>SPINK5<\/strong> \u306f15\u500b\u306e Kazal \u578b\u69d8\u963b\u5bb3\u30c9\u30e1\u30a4\u30f3\u3092\u3082\u3064<strong>\u30bb\u30ea\u30f3\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u963b\u5bb3\u56e0\u5b50 LEKTI<\/strong> \u3092\u30b3\u30fc\u30c9\u3057\u3001LEKTI \u306f\u524d\u99c6\u4f53\u3068\u3057\u3066\u5206\u6ccc\u3055\u308c\u305f\u306e\u3061\u5207\u65ad\u3055\u308c\u3001\u89d2\u5c64\u3067<strong>\u30ab\u30ea\u30af\u30ec\u30a4\u30f3\u95a2\u9023\u30da\u30d7\u30c1\u30c0\u30fc\u30bc\uff08KLK5\u3001KLK7\u3001KLK14\uff09\u3092 pH \u4f9d\u5b58\u7684\u306b\u963b\u5bb3\u3059\u308b<\/strong>\u3002LEKTI \u304c\u6b20\u640d\u3059\u308b\u3068 KLK5 \u3092\u8d77\u70b9\u3068\u3059\u308b\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u30ab\u30b9\u30b1\u30fc\u30c9\u304c\u904e\u5270\u306b\u6d3b\u6027\u5316\u3057\u3001<strong>\u30c7\u30b9\u30e2\u30b0\u30ec\u30a4\u30f31\u306a\u3069\u306e\u30b3\u30eb\u30cd\u30aa\u30c7\u30b9\u30e2\u30bd\u30fc\u30e0\u69cb\u6210\u305f\u3093\u3071\u304f\u304c\u65e9\u671f\u306b\u5206\u89e3\u3055\u308c\u3066\u89d2\u5c64\u5265\u96e2\u304c\u4ea2\u9032<\/strong>\u3057\u3001\u91cd\u5ea6\u306e\u30d0\u30ea\u30a2\u969c\u5bb3\u3092\u751f\u3058\u308b\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\"><strong>KLK5 \u306f PAR2\uff08\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u6d3b\u6027\u5316\u53d7\u5bb9\u4f532\uff09\u3092\u6d3b\u6027\u5316\u3057\u3066 TSLP \u306a\u3069\u306e\u7523\u751f\u3092\u4fc3\u3057\u3001\u76ae\u819a\u3092\u8d77\u70b9\u3068\u3057\u305f Th2 \u578b\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u708e\u75c7\u3092\u8a98\u5c0e\u3059\u308b<\/strong>\u3002\u3053\u308c\u304c\u30d0\u30ea\u30a2\u969c\u5bb3\u306b\u52a0\u3048\u3066\u3001\u9ad8 IgE \u8840\u75c7\u3084\u591a\u5f69\u306a\u30a2\u30ec\u30eb\u30ae\u30fc\u75c7\u72b6\u3092\u8aac\u660e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002\u8fd1\u5e74\u306f Th17 \u7cfb\u306e\u708e\u75c7\u306e\u95a2\u4e0e\u3082\u793a\u3055\u308c\u3001IL-17 \u3084 IL-23 \u3092\u6a19\u7684\u3068\u3059\u308b\u751f\u7269\u5b66\u7684\u88fd\u5264\u306e\u4f7f\u7528\u5831\u544a\u304c\u5897\u3048\u3066\u3044\u308b\u3002<strong>\u5909\u7570\u306e\u591a\u304f\u306f\u30ca\u30f3\u30bb\u30f3\u30b9\u5909\u7570\u3084\u30d5\u30ec\u30fc\u30e0\u30b7\u30d5\u30c8\u5909\u7570\u306a\u3069\u306e\u6a5f\u80fd\u55aa\u5931\u578b\u3067\u3001LEKTI \u306e\u767a\u73fe\u304c\u307e\u3063\u305f\u304f\u5931\u308f\u308c\u308b\u4f8b\u307b\u3069\u91cd\u75c7\u306b\u306a\u308b\u50be\u5411\u304c\u3042\u308b<\/strong>\u304c\u3001\u540c\u3058\u5909\u7570\u3067\u3082\u91cd\u75c7\u5ea6\u306b\u5e45\u304c\u3042\u308b\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\">\u9451\u5225\u3068\u3057\u3066\u306f\u3001\u5e38\u67d3\u8272\u4f53\u6f5c\u6027\u5148\u5929\u6027\u9b5a\u9c57\u766c\uff08<em>TGM1<\/em>\u3001<em>ALOX12B<\/em> \u306a\u3069\uff09\u3001\u5265\u8131\u6027\u76ae\u819a\u75c7B\u578b\uff08<em>CDSN<\/em>\uff09\u3001SAM \u75c7\u5019\u7fa4\uff08<em>DSG1<\/em>\uff09\u3001\u91cd\u75c7\u306e\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3001\u7d05\u76ae\u75c7\u3092\u4f34\u3046\u539f\u767a\u6027\u514d\u75ab\u4e0d\u5168\u75c7\uff08\u30aa\u30fc\u30e1\u30f3\u75c7\u5019\u7fa4\u306a\u3069\uff09\u304c\u6319\u304c\u308b\u3002<strong>\u3068\u304f\u306b\u65b0\u751f\u5150\u671f\u306e\u7d05\u76ae\u75c7\u3067\u306f\u3001\u6bdb\u9aea\u6240\u898b\u3068 LEKTI \u514d\u75ab\u67d3\u8272\u3001\u907a\u4f1d\u5b66\u7684\u691c\u67fb\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u65e9\u671f\u306b\u78ba\u5b9a\u3059\u308b\u3053\u3068\u304c\u3001\u514d\u75ab\u4e0d\u5168\u75c7\u3068\u306e\u533a\u5225\u3084\u5916\u7528\u85ac\u306e\u5b89\u5168\u306a\u9078\u629e\u3001\u6b21\u5b50\u306e\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306b\u76f4\u7d50\u3059\u308b\u3002<\/strong><\/p>\n\n\n<h2 class=\"wp-block-heading\">\u3088\u304f\u3042\u308b\u8cea\u554f<\/h2>\n\n\n<h3 class=\"wp-block-heading\">Q. \u6b21\u306e\u304a\u5b50\u3055\u307e\u3078\u306e\u5f71\u97ff\u306f\u3042\u308a\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u3053\u306e\u75c5\u6c17\u306f\u5e38\u67d3\u8272\u4f53\u6f5c\u6027\u907a\u4f1d\u306e\u305f\u3081\u3001\u3054\u4e21\u89aa\u304c\u3069\u3061\u3089\u3082\u30ad\u30e3\u30ea\u30a2\u306e\u5834\u5408\u3001\u304a\u5b50\u3055\u307e\u3054\u3068\u306b4\u5206\u306e1\u306e\u78ba\u7387\u3067\u767a\u75c7\u3057\u307e\u3059\u3002<\/strong>\u767a\u75c7\u3057\u306a\u3044\u304a\u5b50\u3055\u307e\u306e\u591a\u304f\u306f\u30ad\u30e3\u30ea\u30a2\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u30ad\u30e3\u30ea\u30a2\u306e\u65b9\u306b\u75c7\u72b6\u306f\u51fa\u307e\u305b\u3093\u3002<strong>\u524d\u306e\u304a\u5b50\u3055\u307e\u3067\u539f\u56e0\u3068\u306a\u308b\u907a\u4f1d\u5b50\u306e\u5909\u5316\u304c\u78ba\u5b9a\u3057\u3066\u3044\u308c\u3070\u3001\u6b21\u306e\u598a\u5a20\u3067\u306e\u691c\u67fb\u3092\u5177\u4f53\u7684\u306b\u691c\u8a0e\u3067\u304d\u307e\u3059\u3002<\/strong><\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u598a\u5a20\u4e2d\u306b\u5206\u304b\u308a\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u3053\u306e\u75c5\u6c17\u306f\u3001\u598a\u5a20\u4e2d\u306e\u8d85\u97f3\u6ce2\u691c\u67fb\u3067\u306f\u3075\u3064\u3046\u7570\u5e38\u3068\u3057\u3066\u898b\u3064\u304b\u308a\u307e\u305b\u3093\u3002<\/strong>\u524d\u306e\u304a\u5b50\u3055\u307e\u3067\u539f\u56e0\u3068\u306a\u308b\u907a\u4f1d\u5b50\u306e\u5909\u5316\u304c\u308f\u304b\u3063\u3066\u3044\u308b\u5834\u5408\u306b\u306f\u3001\u305d\u306e\u5909\u5316\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u51fa\u751f\u524d\u306b\u8a3a\u65ad\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3068\u306f\u3069\u3046\u9055\u3046\u306e\u3067\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u30cd\u30b6\u30fc\u30c8\u30f3\u75c7\u5019\u7fa4\u306f\u3001\u751f\u307e\u308c\u305f\u3068\u304d\u304b\u3089\u5168\u8eab\u304c\u8d64\u304f\u76ae\u304c\u3080\u3051\u3066\u3044\u308b\u3053\u3068\u3084\u3001\u9aea\u306e\u6bdb\u304c\u7af9\u306e\u7bc0\u306e\u3088\u3046\u306b\u6298\u308c\u3084\u3059\u3044\u3053\u3068\u304c\u5927\u304d\u306a\u9055\u3044\u3067\u3059\u3002<\/strong>\u4e73\u5150\u671f\u306b\u306f\u533a\u5225\u304c\u96e3\u3057\u3044\u3053\u3068\u3082\u3042\u308a\u3001\u3075\u3064\u3046\u306e\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u6cbb\u7642\u3067\u6539\u5584\u3057\u306b\u304f\u3044\u5834\u5408\u3084\u3001\u9aea\u306e\u6bdb\u306e\u7570\u5e38\u304c\u3042\u308b\u5834\u5408\u306b\u306f\u3001\u3053\u306e\u75c5\u6c17\u3092\u8003\u3048\u3066\u8a73\u3057\u304f\u8abf\u3079\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u5927\u304d\u304f\u306a\u308b\u306b\u3064\u308c\u3066\u75c7\u72b6\u306f\u3069\u3046\u306a\u308a\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u3082\u3063\u3068\u3082\u5371\u967a\u306a\u306e\u306f\u751f\u307e\u308c\u3066\u3059\u3050\u306e\u6642\u671f\u3067\u3001\u4e73\u5150\u671f\u3092\u4e57\u308a\u8d8a\u3048\u308b\u3068\u5168\u8eab\u306e\u72b6\u614b\u306f\u843d\u3061\u7740\u3044\u3066\u304f\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002<\/strong>\u305f\u3060\u3057\u3001\u76ae\u819a\u306e\u8d64\u307f\u3084\u76ae\u3080\u3051\u3001\u304b\u3086\u307f\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u306f\u7a0b\u5ea6\u306b\u5dee\u306f\u3042\u3063\u3066\u3082\u7d9a\u304f\u3053\u3068\u304c\u307b\u3068\u3093\u3069\u3067\u3001\u6bce\u65e5\u306e\u30b9\u30ad\u30f3\u30b1\u30a2\u3068\u5b9a\u671f\u7684\u306a\u8a3a\u5bdf\u304c\u5fc5\u8981\u3067\u3059\u3002\u75c7\u72b6\u306e\u91cd\u3055\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u3001\u5b66\u6821\u3084\u4ed5\u4e8b\u306a\u3069\u793e\u4f1a\u751f\u6d3b\u3092\u9001\u3063\u3066\u3044\u308b\u65b9\u3082\u591a\u304f\u3044\u3089\u3063\u3057\u3083\u3044\u307e\u3059\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067\u306f\u4f55\u3092\u76f8\u8ac7\u3067\u304d\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. \u8a3a\u65ad\u306e\u610f\u5473\u3001\u6b21\u306e\u304a\u5b50\u3055\u307e\u3078\u306e\u5f71\u97ff\u3001\u51fa\u751f\u524d\u691c\u67fb\u3084\u7740\u5e8a\u524d\u691c\u67fb\u306e\u9078\u629e\u80a2\u3001\u3054\u304d\u3087\u3046\u3060\u3044\u3084\u3054\u89aa\u65cf\u3078\u306e\u5f71\u97ff\u306a\u3069\u3092\u3054\u76f8\u8ac7\u3044\u305f\u3060\u3051\u307e\u3059\u3002\u5224\u65ad\u3092\u6025\u304c\u305b\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n<h2 class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e<\/h2>\n\n\n<ul class=\"wp-block-list\">\n<li>Chavanas S, Bodemer C, Rochat A, et al. Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome. <em>Nat Genet<\/em>. 2000;25(2):141-142.<\/li>\n\n\n\n<li>Bitoun E, Chavanas S, Irvine AD, et al. Netherton syndrome: disease expression and spectrum of SPINK5 mutations in 21 families. <em>J Invest Dermatol<\/em>. 2002;118(2):352-361.<\/li>\n\n\n\n<li>Descargues P, Deraison C, Bonnart C, et al. Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity. <em>Nat Genet<\/em>. 2005;37(1):56-65.<\/li>\n\n\n\n<li>Hovnanian A. Netherton syndrome: skin inflammation and allergy by loss of protease inhibition. <em>Cell Tissue Res<\/em>. 2013;351(2):289-300.<\/li>\n\n\n\n<li>OMIM #256500 Netherton Syndrome. Online Mendelian Inheritance in Man.<\/li>\n\n\n<\/ul>\n","protected":false},"featured_media":0,"menu_order":0,"template":"page_gd.php","class_list":["post-147468","genetic-diseases","type-genetic-diseases","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/147468","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/genetic-diseases"}],"version-history":[{"count":0,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/147468\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=147468"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}