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class=\"wp-block-paragraph\"><strong>\u73fe\u6642\u70b9\u3067\u3001\u3053\u306e\u75c5\u6c17\u306e\u9032\u884c\u3092\u6b62\u3081\u305f\u308a\u6cbb\u3057\u305f\u308a\u3059\u308b\u6cbb\u7642\u306f\u78ba\u7acb\u3057\u3066\u3044\u307e\u305b\u3093\u3002<\/strong>\u75c5\u6c17\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u85ac\u306e\u7814\u7a76\u304c\u56fd\u5185\u5916\u3067\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u307e\u3060\u7814\u7a76\u6bb5\u968e\u3067\u3059\u3002\u73fe\u5728\u306f\u3001<strong>\u305d\u308c\u305e\u308c\u306e\u75c7\u72b6\u306b\u5408\u308f\u305b\u305f\u6cbb\u7642\u3068\u3001\u751f\u6d3b\u3092\u652f\u3048\u308b\u652f\u63f4<\/strong>\u304c\u4e2d\u5fc3\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7cd6\u5c3f\u75c5\u306e\u6cbb\u7642<\/strong>\uff1a\u30a4\u30f3\u30b9\u30ea\u30f3\u6ce8\u5c04\u3067\u8840\u7cd6\u3092\u6574\u3048\u307e\u3059\u3002\u8840\u7cd6\u3092\u826f\u3044\u72b6\u614b\u306b\u4fdd\u3064\u3053\u3068\u306f\u3001\u5408\u4f75\u75c7\u3092\u9632\u3050\u3046\u3048\u3067\u5927\u5207\u3067\u3059<\/li>\n\n\n\n<li><strong>\u5c3f\u5d29\u75c7\u306e\u6cbb\u7642<\/strong>\uff1a\u4e0d\u8db3\u3057\u3066\u3044\u308b\u30db\u30eb\u30e2\u30f3\u3092\u88dc\u3046\u85ac\uff08\u30c7\u30b9\u30e2\u30d7\u30ec\u30b7\u30f3\uff09\u3092\u4f7f\u3044\u307e\u3059<\/li>\n\n\n\n<li><strong>\u898b\u3048\u65b9\u30fb\u805e\u3053\u3048\u65b9\u306e\u652f\u63f4<\/strong>\uff1a\u62e1\u5927\u93e1\u306a\u3069\u306e\u8996\u899a\u88dc\u52a9\u5177\u3001\u88dc\u8074\u5668\u3084\u4eba\u5de5\u5185\u8033\u3001\u5b66\u6821\u3084\u8077\u5834\u3067\u306e\u914d\u616e\u3092\u6d3b\u7528\u3057\u307e\u3059<\/li>\n\n\n\n<li><strong>\u5c3f\u306e\u901a\u308a\u9053\u306e\u30b1\u30a2<\/strong>\uff1a\u6ccc\u5c3f\u5668\u79d1\u3067\u5b9a\u671f\u7684\u306b\u8abf\u3079\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u81ea\u5df1\u5c0e\u5c3f\u306a\u3069\u3067\u814e\u81d3\u3092\u5b88\u308a\u307e\u3059<\/li>\n\n\n\n<li><strong>\u795e\u7d4c\u30fb\u547c\u5438\u30fb\u98f2\u307f\u8fbc\u307f\u306e\u898b\u5b88\u308a<\/strong>\uff1a\u5b9a\u671f\u7684\u306a\u8a3a\u5bdf\u3067\u5909\u5316\u3092\u65e9\u304f\u3068\u3089\u3048\u3001\u30ea\u30cf\u30d3\u30ea\u3084\u547c\u5438\u306e\u88dc\u52a9\u306a\u3069\u3092\u691c\u8a0e\u3057\u307e\u3059<\/li>\n\n\n\n<li><strong>\u5fc3\u306e\u30b1\u30a2\u3068\u3054\u5bb6\u65cf\u3078\u306e\u652f\u63f4<\/strong>\uff1a\u3054\u672c\u4eba\u3068\u3054\u5bb6\u65cf\u304c\u9577\u3044\u7d4c\u904e\u3092\u5b89\u5fc3\u3057\u3066\u904e\u3054\u305b\u308b\u3088\u3046\u3001\u7d99\u7d9a\u7684\u306b\u652f\u3048\u307e\u3059<\/li>\n\n\n<\/ul>\n\n\n<p class=\"wp-block-paragraph\">\u5c0f\u5150\u79d1\u30fb\u5185\u5206\u6ccc\u5185\u79d1\u30fb\u773c\u79d1\u30fb\u8033\u9f3b\u79d1\u30fb\u6ccc\u5c3f\u5668\u79d1\u30fb\u795e\u7d4c\u5185\u79d1\u30fb\u5fc3\u7406\u306e\u5c02\u9580\u8077\u306a\u3069\u304c<strong>\u30c1\u30fc\u30e0\u3067\u9577\u304f\u95a2\u308f\u308b<\/strong>\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n\n\n<h2 class=\"wp-block-heading\">\u3053\u306e\u75be\u60a3\u306f\u691c\u67fb\u3067\u308f\u304b\u308a\u307e\u3059<\/h2>\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u75be\u60a3\u306f\u3001\u539f\u56e0\u3068\u306a\u308b <strong>WFS1<\/strong> \u907a\u4f1d\u5b50\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3001\u767a\u75c7\u524d\u3084\u51fa\u751f\u524d\u306b\u898b\u3064\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30afNIPT\u3067\u306f\u6b21\u306e\u691c\u67fb\u3092\u3054\u7528\u610f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">\u30a8\u30af\u30bd\u30fc\u30e0\u89e3\u6790\u3092\u7528\u3044\u305f\u691c\u67fb\uff081,200\u7a2e\u985e\u4ee5\u4e0a\uff09<\/h3>\n\n\n<p class=\"wp-block-paragraph\">\u30a8\u30af\u30bd\u30fc\u30e0\u89e3\u6790\u306f\u3001\u907a\u4f1d\u5b50\u306e\u3046\u3061\u305f\u3093\u3071\u304f\u8cea\u306e\u8a2d\u8a08\u56f3\u306b\u3042\u305f\u308b\u90e8\u5206\uff08\u30a8\u30af\u30bd\u30f3\uff09\u3092\u307e\u3068\u3081\u3066\u8aad\u307f\u53d6\u308b\u691c\u67fb\u3067\u3059\u3002\u3053\u306e\u89e3\u6790\u3092\u884c\u3063\u305f\u3046\u3048\u3067\u3001<strong>WFS1<\/strong> \u907a\u4f1d\u5b50\u3092\u542b\u3080<strong>1,200\u7a2e\u985e\u4ee5\u4e0a<\/strong>\u306e\u907a\u4f1d\u5b50\u3092\u5bfe\u8c61\u306b\u8abf\u3079\u3001<strong>\u3053\u306e\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u308b\u5909\u5316\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059<\/strong>\u3002\u56fd\u5185\u306e\u691c\u67fb\u6240\u3067\u884c\u3044\u3001\u7d50\u679c\u307e\u3067\u306e\u671f\u9593\u306f5\u9031\u9593\u301c7\u9031\u9593\u3067\u3059\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\">\u5e38\u67d3\u8272\u4f53\u6f5c\u6027\uff08\u52a3\u6027\uff09\u907a\u4f1d\u306e\u75be\u60a3\u306f\u3001\u3054\u4e21\u89aa\u304c\u3069\u3061\u3089\u3082\u75c7\u72b6\u306e\u306a\u3044\u300c\u30ad\u30e3\u30ea\u30a2\uff08\u4fdd\u56e0\u8005\uff09\u300d\u3067\u3042\u308b\u3068\u304d\u306b\u3001<strong>4\u5206\u306e1\u306e\u78ba\u7387<\/strong>\u3067\u304a\u5b50\u3055\u307e\u304c\u767a\u75c7\u3057\u307e\u3059\u3002\u691c\u67fb\u306e\u5185\u5bb9\u30fb\u8cbb\u7528\u30fb\u7d50\u679c\u307e\u3067\u306e\u671f\u9593\u306f <a href=\"\/nipt\/nipt\/carrier-screening-1200\/\">\u30ad\u30e3\u30ea\u30a2\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30c6\u30b9\u30c81,200\uff0b\u306e\u30da\u30fc\u30b8<\/a> \u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n<h2 class=\"wp-block-heading\">\u5c02\u9580\u7684\u306a\u89e3\u8aac<\/h2>\n\n\n<p class=\"wp-block-paragraph\"><strong>WFS1<\/strong> \u306f8\u30a8\u30af\u30bd\u30f3\u304b\u3089\u306a\u308a\u3001<strong>9\u56de\u819c\u8cab\u901a\u578b\u306e\u5c0f\u80de\u4f53\u819c\u305f\u3093\u3071\u304f\u8cea\u30a6\u30a9\u30eb\u30d5\u30e9\u30df\u30f3<\/strong>\u3092\u30b3\u30fc\u30c9\u3059\u308b\u3002\u30a6\u30a9\u30eb\u30d5\u30e9\u30df\u30f3\u306f\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\uff08unfolded protein response\uff09\u306e\u5236\u5fa1\u3068\u5c0f\u80de\u4f53\u5185\u30ab\u30eb\u30b7\u30a6\u30e0\u6052\u5e38\u6027\u306e\u7dad\u6301\u306b\u95a2\u4e0e\u3057\u3001<strong>\u6b20\u640d\u306b\u3088\u308a\u81b5\u03b2\u7d30\u80de\u3068\u795e\u7d4c\u7d30\u80de\u3067\u6162\u6027\u7684\u306a\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u304c\u751f\u3058\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u3088\u308b\u9032\u884c\u6027\u306e\u7d30\u80de\u8131\u843d\u3092\u6765\u3059<\/strong>\u30021998\u5e74\u306b Inoue \u3089\u3068 Strom \u3089\u306b\u3088\u308a\u72ec\u7acb\u306b\u539f\u56e0\u907a\u4f1d\u5b50\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u305f\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\">\u5178\u578b\u7684\u306a\u7d4c\u904e\u306f\u3001<strong>\u975e\u81ea\u5df1\u514d\u75ab\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u4f9d\u5b58\u6027\u7cd6\u5c3f\u75c5\uff08\u4e2d\u592e\u50246\u6b73\u524d\u5f8c\uff09\u2192\u8996\u795e\u7d4c\u840e\u7e2e\uff0811\u6b73\u524d\u5f8c\uff09\u2192\u4e2d\u67a2\u6027\u5c3f\u5d29\u75c7\u30fb\u611f\u97f3\u96e3\u8074\uff0810\u4ee3\uff09\u2192\u5c3f\u8def\u969c\u5bb3\uff0820\u4ee3\uff09\u2192\u8133\u5e79\u30fb\u5c0f\u8133\u3092\u4e3b\u4f53\u3068\u3059\u308b\u795e\u7d4c\u5909\u6027\uff0830\u4ee3\u4ee5\u964d\uff09<\/strong>\u3067\u3042\u308b\u3002\u82f1\u56fd\u306e\u5168\u56fd\u8abf\u67fb\uff08Barrett \u3089\u30011995\uff09\u3067\u306f\u6b7b\u4ea1\u5e74\u9f62\u306e\u4e2d\u592e\u5024\u306f30\u6b73\u524d\u5f8c\u3067\u3001<strong>\u4e3b\u306a\u6b7b\u56e0\u306f\u8133\u5e79\u840e\u7e2e\u306b\u3088\u308b\u4e2d\u67a2\u6027\u547c\u5438\u4e0d\u5168<\/strong>\u3067\u3042\u3063\u305f\u3002\u4e21\u30a2\u30ec\u30eb\u3068\u3082\u6a5f\u80fd\u55aa\u5931\u578b\uff08\u30ca\u30f3\u30bb\u30f3\u30b9\u30fb\u30d5\u30ec\u30fc\u30e0\u30b7\u30d5\u30c8\uff09\u306e\u4f8b\u306f\u767a\u75c7\u304c\u65e9\u304f\u91cd\u75c7\u3068\u306a\u308b\u50be\u5411\u304c\u3042\u308a\u3001\u30df\u30b9\u30bb\u30f3\u30b9\u5909\u7570\u3092\u542b\u3080\u4f8b\u3067\u306f\u3088\u308a\u8efd\u75c7\u306e\u7d4c\u904e\u3092\u3068\u308b\u3053\u3068\u304c\u3042\u308b\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\"><strong>\u672c\u907a\u4f1d\u5b50\u306f\u6f5c\u6027\u3068\u9855\u6027\u306e\u4e21\u65b9\u306e\u75be\u60a3\u3092\u8d77\u3053\u3059\u70b9\u306b\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002<\/strong>\u7279\u5b9a\u306e\u30df\u30b9\u30bb\u30f3\u30b9\u5909\u7570\u306f\u30d8\u30c6\u30ed\u63a5\u5408\u3067<strong>\u4f4e\u97f3\u57df\u304b\u3089\u59cb\u307e\u308b\u975e\u75c7\u5019\u7fa4\u6027\u611f\u97f3\u96e3\u8074\uff08DFNA6\/14\/38\uff09<\/strong>\u3084\u3001\u96e3\u8074\u30fb\u8996\u795e\u7d4c\u840e\u7e2e\u30fb\u7cd6\u5c3f\u75c5\u306e\u4e00\u90e8\u3092\u4f34\u3046<strong>\u9855\u6027\u306e\u30a6\u30a9\u30eb\u30d5\u30e9\u30e0\u69d8\u75c7\u5019\u7fa4<\/strong>\u3092\u8d77\u3053\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u30ad\u30e3\u30ea\u30a2\u3068\u5224\u5b9a\u3055\u308c\u305f\u5834\u5408\u3067\u3082\u3001\u691c\u51fa\u3055\u308c\u305f\u5909\u7570\u306e\u7a2e\u985e\u306b\u3088\u3063\u3066\u306f\u672c\u4eba\u306e\u75c7\u72b6\u8a55\u4fa1\u304c\u5fc5\u8981\u3068\u306a\u308b\u3002\u9451\u5225\u3068\u3057\u3066\u306f\u3001<strong>\u30a6\u30a9\u30eb\u30d5\u30e9\u30e0\u75c7\u5019\u7fa42\u578b\uff08<em>CISD2<\/em>\u3001\u5c3f\u5d29\u75c7\u3092\u6b20\u304d\u6d88\u5316\u7ba1\u6f70\u760d\u30fb\u51fa\u8840\u50be\u5411\u3092\u4f34\u3046\uff09<\/strong>\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\uff08\u6bcd\u7cfb\u907a\u4f1d\u306e\u7cd6\u5c3f\u75c5\u30fb\u96e3\u8074\uff09\u3001\u30c1\u30a2\u30df\u30f3\u53cd\u5fdc\u6027\u5de8\u8d64\u82bd\u7403\u6027\u8ca7\u8840\u75c7\u5019\u7fa4\uff08<em>SLC19A2<\/em>\uff09\u3001\u907a\u4f1d\u6027\u8996\u795e\u7d4c\u75c7\u304c\u6319\u304c\u308b\u3002<\/p>\n\n\n<h2 class=\"wp-block-heading\">\u3088\u304f\u3042\u308b\u8cea\u554f<\/h2>\n\n\n<h3 class=\"wp-block-heading\">Q. \u6b21\u306e\u304a\u5b50\u3055\u307e\u3078\u306e\u5f71\u97ff\u306f\u3042\u308a\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u3053\u306e\u75c5\u6c17\u306f\u5e38\u67d3\u8272\u4f53\u6f5c\u6027\u907a\u4f1d\u306e\u305f\u3081\u3001\u3054\u4e21\u89aa\u304c\u3069\u3061\u3089\u3082\u30ad\u30e3\u30ea\u30a2\u306e\u5834\u5408\u3001\u304a\u5b50\u3055\u307e\u3054\u3068\u306b4\u5206\u306e1\u306e\u78ba\u7387\u3067\u767a\u75c7\u3057\u307e\u3059\u3002<\/strong>\u7537\u306e\u5b50\u30fb\u5973\u306e\u5b50\u3067\u78ba\u7387\u306f\u5909\u308f\u308a\u307e\u305b\u3093\u3002\u75c7\u72b6\u306e\u306a\u3044\u3054\u304d\u3087\u3046\u3060\u3044\u304c\u30ad\u30e3\u30ea\u30a2\u3067\u3042\u308b\u78ba\u7387\u306f3\u5206\u306e2\u3067\u3059\u3002<strong>\u898b\u901a\u3057\u3092\u6b63\u3057\u304f\u304a\u4f1d\u3048\u3059\u308b\u305f\u3081\u3001\u539f\u56e0\u907a\u4f1d\u5b50\u3092\u78ba\u5b9a\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/strong><\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u598a\u5a20\u4e2d\u306b\u5206\u304b\u308a\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u751f\u307e\u308c\u305f\u3068\u304d\u306b\u306f\u75c7\u72b6\u304c\u306a\u3044\u305f\u3081\u3001\u598a\u5a20\u4e2d\u306e\u8d85\u97f3\u6ce2\u691c\u67fb\u3067\u306f\u898b\u3064\u304b\u308a\u307e\u305b\u3093\u3002<\/strong>\u3054\u5bb6\u65cf\u3067\u3059\u3067\u306b\u8a3a\u65ad\u304c\u3064\u3044\u3066\u3044\u308b\u5834\u5408\u3084\u3001\u3054\u4e21\u89aa\u304c\u30ad\u30e3\u30ea\u30a2\u3068\u308f\u304b\u3063\u3066\u3044\u308b\u5834\u5408\u306f\u3001\u907a\u4f1d\u5b50\u3092\u8abf\u3079\u308b\u51fa\u751f\u524d\u691c\u67fb\u3092\u691c\u8a0e\u3067\u304d\u307e\u3059\u3002\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u3075\u3064\u3046\u306e1\u578b\u7cd6\u5c3f\u75c5\u3068\u306f\u9055\u3046\u306e\u3067\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. \u306f\u3044\u3002<strong>\u30a4\u30f3\u30b9\u30ea\u30f3\u6ce8\u5c04\u304c\u5fc5\u8981\u306a\u70b9\u306f\u540c\u3058\u3067\u3059\u304c\u3001\u81ea\u5df1\u514d\u75ab\u3067\u306f\u306a\u304f\u3001\u7d30\u80de\u304c\u5c11\u3057\u305a\u3064\u5f31\u3063\u3066\u3044\u304f\u3053\u3068\u304c\u539f\u56e0\u3067\u3059\u3002<\/strong>\u5b50\u3069\u3082\u306e\u7cd6\u5c3f\u75c5\u306b\u8996\u529b\u306e\u4f4e\u4e0b\u304c\u52a0\u308f\u3063\u305f\u3068\u304d\u306f\u3001\u3053\u306e\u75c5\u6c17\u3092\u8003\u3048\u3066\u773c\u79d1\u3067\u306e\u691c\u67fb\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u52e7\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u30ad\u30e3\u30ea\u30a2\u306e\u79c1\u306b\u3082\u75c7\u72b6\u304c\u51fa\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u591a\u304f\u306e\u30ad\u30e3\u30ea\u30a2\u306e\u65b9\u306f\u75c7\u72b6\u304c\u306a\u304f\u3001\u3075\u3060\u3093\u3069\u304a\u308a\u751f\u6d3b\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/strong>\u305f\u3060\u3057\u3001WFS1 \u907a\u4f1d\u5b50\u306e\u4e00\u90e8\u306e\u7279\u5b9a\u306e\u5909\u5316\u3067\u306f\u30011\u3064\u3060\u3051\u3067\u3082\u96e3\u8074\u306a\u3069\u304c\u73fe\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<strong>\u3069\u306e\u5909\u5316\u304c\u898b\u3064\u304b\u3063\u305f\u304b\u306b\u3088\u3063\u3066\u8aac\u660e\u304c\u5909\u308f\u308b\u305f\u3081\u3001\u7d50\u679c\u306f\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067\u8a73\u3057\u304f\u304a\u4f1d\u3048\u3057\u307e\u3059\u3002<\/strong><\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067\u306f\u4f55\u3092\u76f8\u8ac7\u3067\u304d\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. \u8a3a\u65ad\u306e\u610f\u5473\u3001\u6b21\u306e\u304a\u5b50\u3055\u307e\u3078\u306e\u5f71\u97ff\u3001\u51fa\u751f\u524d\u691c\u67fb\u3084\u7740\u5e8a\u524d\u691c\u67fb\u306e\u9078\u629e\u80a2\u3001\u3054\u304d\u3087\u3046\u3060\u3044\u3084\u3054\u89aa\u65cf\u3078\u306e\u5f71\u97ff\u306a\u3069\u3092\u3054\u76f8\u8ac7\u3044\u305f\u3060\u3051\u307e\u3059\u3002\u5224\u65ad\u3092\u6025\u304c\u305b\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n<h2 class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e<\/h2>\n\n\n<ul class=\"wp-block-list\">\n<li>Tranebj\u00e6rg L, Barrett T, Rendtorff ND. WFS1 Spectrum Disorder. In: Adam MP, et al., editors. GeneReviews\u00ae. Seattle (WA): University of Washington, Seattle; 1993-.<\/li>\n\n\n\n<li>OMIM #222300 Wolfram syndrome 1; WFS1. Online Mendelian Inheritance in Man.<\/li>\n\n\n\n<li>Inoue H, Tanizawa Y, Wasson J, et al. A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). <em>Nat Genet<\/em>. 1998;20(2):143-148.<\/li>\n\n\n\n<li>Strom TM, H\u00f6rtnagel K, Hofmann S, et al. Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein. <em>Hum Mol Genet<\/em>. 1998;7(13):2021-2028.<\/li>\n\n\n\n<li>Barrett TG, Bundey SE, Macleod AF. Neurodegeneration and diabetes: UK nationwide study of Wolfram (DIDMOAD) syndrome. <em>Lancet<\/em>. 1995;346(8988):1458-1463.<\/li>\n\n\n<\/ul>\n","protected":false},"featured_media":0,"menu_order":0,"template":"page_gd.php","class_list":["post-147482","genetic-diseases","type-genetic-diseases","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/147482","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/genetic-diseases"}],"version-history":[{"count":0,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/147482\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=147482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}