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class=\"wp-block-paragraph\"><strong>\u3053\u306e\u75c5\u6c17\u3067\u306f\u6210\u9577\u30db\u30eb\u30e2\u30f3\u306e\u6ce8\u5c04\u306f\u52b9\u304d\u307e\u305b\u3093\u3002<\/strong>\u4ee3\u308f\u308a\u306b\u3001<strong>\u4e0d\u8db3\u3057\u3066\u3044\u308bIGF-1\u305d\u306e\u3082\u306e\u3092\u88dc\u3046\u6ce8\u5c04\uff08\u30e1\u30ab\u30bb\u30eb\u30df\u30f3\uff09<\/strong>\u304c\u56fd\u5185\u3067\u3082\u4f7f\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u65e9\u304f\u59cb\u3081\u308b\u307b\u3069\u8eab\u9577\u306e\u4f38\u3073\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u304c\u3001<strong>\u52b9\u679c\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u3001\u5e73\u5747\u7684\u306a\u8eab\u9577\u306b\u5c4a\u304b\u306a\u3044\u3053\u3068\u3082\u5c11\u306a\u304f\u3042\u308a\u307e\u305b\u3093\u3002<\/strong>\u9577\u671f\u306b\u308f\u305f\u308b\u6cbb\u7642\u3068\u306a\u308b\u305f\u3081\u3001\u5c0f\u5150\u306e\u5185\u5206\u6ccc\u3092\u5c02\u9580\u3068\u3059\u308b\u533b\u5e2b\u306e\u3082\u3068\u3067\u7d9a\u3051\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IGF-1\u88fd\u5264\u306e\u6ce8\u5c04<\/strong>\uff1a\u901a\u5e38\u306f1\u65e52\u56de\u3001\u98df\u4e8b\u306b\u5408\u308f\u305b\u3066\u76ae\u4e0b\u306b\u6ce8\u5c04\u3057\u307e\u3059<\/li>\n\n\n\n<li><strong>\u526f\u4f5c\u7528\u3078\u306e\u6ce8\u610f<\/strong>\uff1a<strong>\u4f4e\u8840\u7cd6\u304c\u3082\u3063\u3068\u3082\u6ce8\u610f\u3059\u3079\u304d\u526f\u4f5c\u7528<\/strong>\u3067\u3001\u307b\u304b\u306b\u6241\u6843\u306e\u816b\u308c\u3001\u982d\u75db\uff08\u982d\u306e\u4e2d\u306e\u5727\u304c\u4e0a\u304c\u308b\uff09\u3001\u6ce8\u5c04\u90e8\u4f4d\u306e\u8102\u80aa\u306e\u5909\u5316\u306a\u3069\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059<\/li>\n\n\n\n<li><strong>\u4e73\u5e7c\u5150\u671f\u306e\u4f4e\u8840\u7cd6\u5bfe\u7b56<\/strong>\uff1a\u3053\u307e\u3081\u306a\u6388\u4e73\u30fb\u98df\u4e8b\u306a\u3069\u3001\u7a7a\u8179\u306e\u6642\u9593\u3092\u9577\u304f\u3057\u306a\u3044\u5de5\u592b<\/li>\n\n\n\n<li><strong>\u4f53\u91cd\u30fb\u98df\u4e8b\u306e\u7ba1\u7406<\/strong>\uff1a\u4f53\u8102\u80aa\u304c\u5897\u3048\u3084\u3059\u3044\u305f\u3081\u3001\u6210\u9577\u306b\u5408\u308f\u305b\u305f\u6804\u990a\u6307\u5c0e<\/li>\n\n\n\n<li><strong>\u6b6f\u79d1\u30fb\u8033\u9f3b\u79d1\u306a\u3069\u306e\u5b9a\u671f\u7684\u306a\u8a3a\u5bdf<\/strong><\/li>\n\n\n\n<li><strong>\u5fc3\u7406\u7684\u30fb\u793e\u4f1a\u7684\u306a\u652f\u63f4<\/strong>\uff1a\u8eab\u9577\u306b\u95a2\u3059\u308b\u60a9\u307f\u3084\u5b66\u6821\u751f\u6d3b\u3078\u306e\u914d\u616e\u306b\u3064\u3044\u3066\u3001\u3054\u672c\u4eba\u3068\u3054\u5bb6\u65cf\u3092\u7d99\u7d9a\u3057\u3066\u652f\u3048\u307e\u3059<\/li>\n\n\n<\/ul>\n\n\n<h2 class=\"wp-block-heading\">\u3053\u306e\u75be\u60a3\u306f\u691c\u67fb\u3067\u308f\u304b\u308a\u307e\u3059<\/h2>\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u75be\u60a3\u306f\u3001\u539f\u56e0\u3068\u306a\u308b <strong>GHR<\/strong> \u907a\u4f1d\u5b50\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3001\u767a\u75c7\u524d\u3084\u51fa\u751f\u524d\u306b\u898b\u3064\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30afNIPT\u3067\u306f\u6b21\u306e\u691c\u67fb\u3092\u3054\u7528\u610f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">\u30a8\u30af\u30bd\u30fc\u30e0\u89e3\u6790\u3092\u7528\u3044\u305f\u691c\u67fb\uff081,200\u7a2e\u985e\u4ee5\u4e0a\uff09<\/h3>\n\n\n<p class=\"wp-block-paragraph\">\u30a8\u30af\u30bd\u30fc\u30e0\u89e3\u6790\u306f\u3001\u907a\u4f1d\u5b50\u306e\u3046\u3061\u305f\u3093\u3071\u304f\u8cea\u306e\u8a2d\u8a08\u56f3\u306b\u3042\u305f\u308b\u90e8\u5206\uff08\u30a8\u30af\u30bd\u30f3\uff09\u3092\u307e\u3068\u3081\u3066\u8aad\u307f\u53d6\u308b\u691c\u67fb\u3067\u3059\u3002\u3053\u306e\u89e3\u6790\u3092\u884c\u3063\u305f\u3046\u3048\u3067\u3001<strong>GHR<\/strong> \u907a\u4f1d\u5b50\u3092\u542b\u3080<strong>1,200\u7a2e\u985e\u4ee5\u4e0a<\/strong>\u306e\u907a\u4f1d\u5b50\u3092\u5bfe\u8c61\u306b\u8abf\u3079\u3001<strong>\u3053\u306e\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u308b\u5909\u5316\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059<\/strong>\u3002\u56fd\u5185\u306e\u691c\u67fb\u6240\u3067\u884c\u3044\u3001\u7d50\u679c\u307e\u3067\u306e\u671f\u9593\u306f5\u9031\u9593\u301c7\u9031\u9593\u3067\u3059\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\">\u30e9\u30ed\u30f3\u578b\u5c0f\u4eba\u75c7\u306f\u5e38\u67d3\u8272\u4f53\u6f5c\u6027\uff08\u52a3\u6027\uff09\u907a\u4f1d\u306e\u75be\u60a3\u306e\u305f\u3081\u3001\u3054\u4e21\u89aa\u304c\u3069\u3061\u3089\u3082\u75c7\u72b6\u306e\u306a\u3044\u300c\u30ad\u30e3\u30ea\u30a2\uff08\u4fdd\u56e0\u8005\uff09\u300d\u3067\u3042\u308b\u3068\u304d\u306b\u3001<strong>\u304a\u5b50\u3055\u307e\u3054\u3068\u306b4\u5206\u306e1\u306e\u78ba\u7387<\/strong>\u3067\u767a\u75c7\u3057\u307e\u3059\u3002\u691c\u67fb\u306e\u5185\u5bb9\u30fb\u8cbb\u7528\u30fb\u7d50\u679c\u307e\u3067\u306e\u671f\u9593\u306f <a href=\"\/nipt\/nipt\/carrier-screening-1200\/\">\u30ad\u30e3\u30ea\u30a2\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30c6\u30b9\u30c81,200\uff0b\u306e\u30da\u30fc\u30b8<\/a> \u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n<h2 class=\"wp-block-heading\">\u5c02\u9580\u7684\u306a\u89e3\u8aac<\/h2>\n\n\n<p class=\"wp-block-paragraph\"><strong>GHR<\/strong> \u306f\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u53d7\u5bb9\u4f53\u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3059\u308b1\u56de\u819c\u8cab\u901a\u578b\u53d7\u5bb9\u4f53\u3067\u3001\u6210\u9577\u30db\u30eb\u30e2\u30f3\uff08GH\uff09\u306e\u7d50\u5408\u306b\u3088\u308a\u4e8c\u91cf\u4f53\u306e\u69cb\u9020\u5909\u5316\u304c\u8d77\u3053\u308a\u3001<strong>JAK2\u2013STAT5B\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u809d\u81d3\u3067\u306eIGF-1\u7523\u751f\u3092\u8a98\u5c0e\u3059\u308b<\/strong>\u3002\u7d30\u80de\u5916\u30c9\u30e1\u30a4\u30f3\u304c\u30bf\u30f3\u30d1\u30af\u5206\u89e3\u3067\u5207\u308a\u51fa\u3055\u308c\u305f\u3082\u306e\u304c\u8840\u4e2d\u306e<strong>GH\u7d50\u5408\u30bf\u30f3\u30d1\u30af\uff08GHBP\uff09<\/strong>\u3067\u3042\u308b\u30021966\u5e74\u306bLaron\u3089\u304c\u30a4\u30b9\u30e9\u30a8\u30eb\u306e\u5bb6\u7cfb\u3067\u300cGH\u304c\u9ad8\u5024\u306e\u907a\u4f1d\u6027\u4e0b\u5782\u4f53\u6027\u5c0f\u4eba\u75c7\u300d\u3068\u3057\u3066\u5831\u544a\u3057\u30011989\u5e74\u306bGHR\u907a\u4f1d\u5b50\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosome-partial-deletion-guide\/\">\u90e8\u5206\u6b20\u5931<\/a>\u304c\u521d\u3081\u3066\u540c\u5b9a\u3055\u308c\u305f\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5909\u7570\u306e\u591a\u304f\u306f\u7d30\u80de\u5916\u30c9\u30e1\u30a4\u30f3\u306b\u96c6\u307e\u308a\u3001GHBP\u304c\u4f4e\u5024\u3068\u306a\u308b<\/strong>\u3002\u4e00\u65b9\u3001\u819c\u8cab\u901a\u30c9\u30e1\u30a4\u30f3\u3084\u7d30\u80de\u5185\u30c9\u30e1\u30a4\u30f3\u306e\u5909\u7570\u3001\u4e8c\u91cf\u4f53\u5316\u306e\u307f\u3092\u969c\u5bb3\u3059\u308b\u5909\u7570\u3067\u306fGHBP\u304c\u6b63\u5e38\u301c\u9ad8\u5024\u3068\u306a\u308b\u305f\u3081\u3001<strong>GHBP\u304c\u6b63\u5e38\u3067\u3082\u672c\u75c7\u306f\u5426\u5b9a\u3067\u304d\u306a\u3044<\/strong>\u3002<strong>\u30a8\u30af\u30a2\u30c9\u30eb\u306e\u5927\u898f\u6a21\u96c6\u56e3\uff08\u5275\u59cb\u8005\u5909\u7570 E180 \u306e\u540c\u7fa9\u7f6e\u63db\u306b\u3088\u308b\u30b9\u30d7\u30e9\u30a4\u30b9\u7570\u5e38\uff09\u3067\u306f\u3001\u4f4e\u8eab\u9577\u306b\u3082\u304b\u304b\u308f\u3089\u305a2\u578b\u7cd6\u5c3f\u75c5\u3068\u304c\u3093\u306e\u767a\u751f\u304c\u304d\u308f\u3081\u3066\u5c11\u306a\u3044<\/strong>\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3001IGF-1\u30b7\u30b0\u30ca\u30eb\u3068\u8001\u5316\u7814\u7a76\u306e\u89b3\u70b9\u304b\u3089\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u30a4\u30f3\u30c8\u30ed\u30f3\u5185\u306e\u5909\u7570\u306b\u3088\u308b\u507d\u30a8\u30af\u30bd\u30f3\u306e\u633f\u5165\u3084\u3001\u7d30\u80de\u5185\u30c9\u30e1\u30a4\u30f3\u3092\u6b20\u304f\u512a\u6027\u963b\u5bb3\u578b\u306e\u7247\u30a2\u30ec\u30eb\u5909\u7570\u3067\u306f\u3001<strong>\u3088\u308a\u8efd\u75c7\u306e\u90e8\u5206\u7684GH\u4e0d\u5fdc\u75c7<\/strong>\u3092\u5448\u3059\u308b\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\">\u9451\u5225\u3068\u3057\u3066\u306f\u3001GH\u5206\u6ccc\u4e0d\u5168\uff08<em>GH1<\/em>\u3001<em>GHRHR<\/em> \u306a\u3069\uff09\u3001STAT5B\u6b20\u640d\u75c7\uff08<em>STAT5B<\/em>\u3001\u514d\u75ab\u4e0d\u5168\u3092\u4f34\u3046\uff09\u3001IGF-1\u6b20\u640d\u75c7\uff08<em>IGF1<\/em>\u3001\u5c0f\u982d\u30fb\u96e3\u8074\u30fb<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/why-premium-plan\/\">\u77e5\u7684\u969c\u5bb3<\/a>\u3092\u4f34\u3046\uff09\u3001\u9178\u4e0d\u5b89\u5b9a\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u6b20\u640d\u75c7\uff08<em>IGFALS<\/em>\uff09\u3001IGF-1\u53d7\u5bb9\u4f53\u7570\u5e38\uff08<em>IGF1R<\/em>\u3001IGF-1\u306f\u6b63\u5e38\u301c\u9ad8\u5024\uff09\u304c\u6319\u304c\u308b\u3002<strong>GH\u88dc\u5145\u304c\u6709\u52b9\u306a\u75c5\u614b\u3068IGF-1\u88dc\u5145\u304c\u5fc5\u8981\u306a\u75c5\u614b\u3092\u533a\u5225\u3059\u308b\u305f\u3081\u3001\u5185\u5206\u6ccc\u691c\u67fb\u3068\u907a\u4f1d\u5b50\u8a3a\u65ad\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u304c\u6cbb\u7642\u9078\u629e\u306b\u76f4\u7d50\u3059\u308b\u3002<\/strong><\/p>\n\n\n<h2 class=\"wp-block-heading\">\u3088\u304f\u3042\u308b\u8cea\u554f<\/h2>\n\n\n<h3 class=\"wp-block-heading\">Q. \u6b21\u306e\u304a\u5b50\u3055\u307e\u3078\u306e\u5f71\u97ff\u306f\u3042\u308a\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u3053\u306e\u75c5\u6c17\u306f\u5e38\u67d3\u8272\u4f53\u6f5c\u6027\u907a\u4f1d\u306e\u305f\u3081\u3001\u3054\u4e21\u89aa\u304c\u3069\u3061\u3089\u3082\u30ad\u30e3\u30ea\u30a2\u306e\u5834\u5408\u3001\u304a\u5b50\u3055\u307e\u3054\u3068\u306b4\u5206\u306e1\u306e\u78ba\u7387\u3067\u767a\u75c7\u3057\u307e\u3059\u3002<\/strong>2\u5206\u306e1\u306e\u78ba\u7387\u3067\u75c7\u72b6\u306e\u306a\u3044\u30ad\u30e3\u30ea\u30a2\u3068\u306a\u308a\u30014\u5206\u306e1\u306e\u78ba\u7387\u3067\u5909\u5316\u3092\u53d7\u3051\u7d99\u304e\u307e\u305b\u3093\u3002<strong>\u4f4e\u8eab\u9577\u306b\u306f\u3055\u307e\u3056\u307e\u306a\u539f\u56e0\u304c\u3042\u308b\u305f\u3081\u3001\u307e\u305a\u539f\u56e0\u907a\u4f1d\u5b50\u3092\u78ba\u5b9a\u3059\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/strong><\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u598a\u5a20\u4e2d\u306b\u5206\u304b\u308a\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u751f\u307e\u308c\u305f\u3068\u304d\u306e\u4f53\u306e\u5927\u304d\u3055\u306f\u5e73\u5747\u3088\u308a\u3084\u3084\u5c0f\u3055\u3044\u7a0b\u5ea6\u306e\u3053\u3068\u304c\u591a\u304f\u3001\u598a\u5a20\u4e2d\u306e\u8d85\u97f3\u6ce2\u691c\u67fb\u3067\u6c17\u3065\u304b\u308c\u308b\u3053\u3068\u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u3002<\/strong>\u524d\u306e\u304a\u5b50\u3055\u307e\u3067\u8a3a\u65ad\u304c\u3064\u3044\u3066\u3044\u308b\u5834\u5408\u3084\u3001\u3054\u4e21\u89aa\u304c\u30ad\u30e3\u30ea\u30a2\u3068\u308f\u304b\u3063\u3066\u3044\u308b\u5834\u5408\u306f\u3001\u907a\u4f1d\u5b50\u3092\u8abf\u3079\u308b\u51fa\u751f\u524d\u691c\u67fb\u3092\u691c\u8a0e\u3067\u304d\u307e\u3059\u3002\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u6210\u9577\u30db\u30eb\u30e2\u30f3\u306e\u6ce8\u5c04\u3067\u80cc\u306f\u4f38\u3073\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u3053\u306e\u75c5\u6c17\u3067\u306f\u6210\u9577\u30db\u30eb\u30e2\u30f3\u3092\u53d7\u3051\u53d6\u308b\u53d7\u5bb9\u4f53\u304c\u306f\u305f\u3089\u304b\u306a\u3044\u305f\u3081\u3001\u6210\u9577\u30db\u30eb\u30e2\u30f3\u306e\u6ce8\u5c04\u3067\u306f\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u305b\u3093\u3002<\/strong>\u4ee3\u308f\u308a\u306bIGF-1\u306e\u6ce8\u5c04\u3092\u884c\u3044\u307e\u3059\u3002\u8eab\u9577\u306e\u4f38\u3073\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u3001\u4f4e\u8840\u7cd6\u306a\u3069\u306e\u526f\u4f5c\u7528\u306b\u3082\u6ce8\u610f\u3057\u306a\u304c\u3089\u3001\u5c02\u9580\u533b\u3068\u76f8\u8ac7\u3057\u3066\u9032\u3081\u307e\u3059\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u77e5\u80fd\u3084\u5bff\u547d\u306b\u5f71\u97ff\u306f\u3042\u308a\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u591a\u304f\u306e\u65b9\u3067\u77e5\u7684\u767a\u9054\u306f\u4fdd\u305f\u308c\u3001\u5bff\u547d\u304c\u77ed\u304f\u306a\u308b\u75c5\u6c17\u3068\u306f\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/strong>\u305f\u3060\u3057\u3001\u4e73\u5e7c\u5150\u671f\u306e\u4f4e\u8840\u7cd6\u3092\u898b\u9003\u3055\u306a\u3044\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002\u9032\u5b66\u30fb\u5c31\u52b4\u30fb\u7d50\u5a5a\u30fb\u51fa\u7523\u306a\u3069\u3001\u591a\u304f\u306e\u65b9\u304c\u305d\u308c\u305e\u308c\u306e\u751f\u6d3b\u3092\u9001\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067\u306f\u4f55\u3092\u76f8\u8ac7\u3067\u304d\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. \u8a3a\u65ad\u306e\u610f\u5473\u3001\u6b21\u306e\u304a\u5b50\u3055\u307e\u3078\u306e\u5f71\u97ff\u3001\u51fa\u751f\u524d\u691c\u67fb\u3084\u7740\u5e8a\u524d\u691c\u67fb\u306e\u9078\u629e\u80a2\u3001\u3054\u304d\u3087\u3046\u3060\u3044\u3084\u3054\u89aa\u65cf\u3078\u306e\u5f71\u97ff\u306a\u3069\u3092\u3054\u76f8\u8ac7\u3044\u305f\u3060\u3051\u307e\u3059\u3002\u5224\u65ad\u3092\u6025\u304c\u305b\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n<h2 class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e<\/h2>\n\n\n<ul class=\"wp-block-list\">\n<li>Laron Z, Pertzelan A, Mannheimer S. Genetic pituitary dwarfism with high serum concentration of growth hormone&#8211;a new inborn error of metabolism? <em>Isr J Med Sci<\/em>. 1966;2(2):152-155.<\/li>\n\n\n\n<li>Godowski PJ, Leung DW, Meacham LR, et al. Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism. <em>Proc Natl Acad Sci U S A<\/em>. 1989;86(20):8083-8087.<\/li>\n\n\n\n<li>Rosenfeld RG, Rosenbloom AL, Guevara-Aguirre J. Growth hormone (GH) insensitivity due to primary GH receptor deficiency. <em>Endocr Rev<\/em>. 1994;15(3):369-390.<\/li>\n\n\n\n<li>Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, et al. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. <em>Sci Transl Med<\/em>. 2011;3(70):70ra13.<\/li>\n\n\n\n<li>OMIM #262500 Laron syndrome. Online Mendelian Inheritance in Man.<\/li>\n\n\n<\/ul>\n","protected":false},"featured_media":0,"menu_order":0,"template":"page_gd.php","class_list":["post-147503","genetic-diseases","type-genetic-diseases","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/147503","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/genetic-diseases"}],"version-history":[{"count":0,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/147503\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=147503"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}