{"id":147755,"date":"2026-11-03T03:47:11","date_gmt":"2026-11-02T18:47:11","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/genetic-diseases2\/brunner-syndrome-maoa\/"},"modified":"2026-11-03T03:47:11","modified_gmt":"2026-11-02T18:47:11","slug":"brunner-syndrome-maoa","status":"publish","type":"genetic-diseases","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/genetic-diseases2\/brunner-syndrome-maoa\/","title":{"rendered":"\u30d6\u30eb\u30f3\u30ca\u30fc\u75c7\u5019\u7fa4"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u6982\u8981<\/h2>\n\n\n<p class=\"wp-block-paragraph\">\u30d6\u30eb\u30f3\u30ca\u30fc\u75c7\u5019\u7fa4\u306f\u3001<strong>\u8133\u306e\u306a\u304b\u3067\u6c17\u5206\u3084\u884c\u52d5\u306b\u304b\u304b\u308f\u308b\u7269\u8cea\uff08\u30e2\u30ce\u30a2\u30df\u30f3\uff09\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\u304c\u306f\u305f\u3089\u304b\u306a\u3044\u305f\u3081\u306b\u3001\u8efd\u3044\u77e5\u7684\u767a\u9054\u306e\u9045\u308c\u3068\u3001\u885d\u52d5\u7684\u306a\u884c\u52d5\u3084\u653b\u6483\u7684\u306a\u884c\u52d5\u304c\u7537\u6027\u306b\u73fe\u308c\u308b\u75c5\u6c17<\/strong>\u3067\u3059\u3002X\u9023\u9396\u6f5c\u6027\uff08\u52a3\u6027\uff09\u907a\u4f1d\u306e\u5f62\u5f0f\u3092\u3068\u308a\u3001X\u67d3\u8272\u4f53\uff08Xp11.3\uff09\u306b\u3042\u308b <strong>MAOA<\/strong> \u907a\u4f1d\u5b50\u306e\u5909\u5316\u304c\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u75c5\u6c17\u306f1993\u5e74\u306b\u3001<strong>\u30aa\u30e9\u30f3\u30c0\u306e\u4e00\u3064\u306e\u5bb6\u7cfb\u3067\u3001\u6570\u4e16\u4ee3\u306b\u308f\u305f\u3063\u3066\u7537\u6027\u3060\u3051\u306b\u540c\u3058\u3088\u3046\u306a\u884c\u52d5\u306e\u554f\u984c\u304c\u307f\u3089\u308c\u305f\u3053\u3068<\/strong>\u304b\u3089\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u306b\u5831\u544a\u3055\u308c\u305f\u5bb6\u7cfb\u306f\u3054\u304f\u308f\u305a\u304b\u3067\u3001<strong>\u304d\u308f\u3081\u3066\u307e\u308c\u306a\u75c5\u6c17<\/strong>\u3067\u3059\u3002<strong>\u4f53\u306e\u5f62\u306e\u7570\u5e38\u306f\u307b\u3068\u3093\u3069\u306a\u304f\u3001\u598a\u5a20\u4e2d\u306e\u8d85\u97f3\u6ce2\u691c\u67fb\u3067\u6c17\u3065\u304b\u308c\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/strong><\/p>\n\n\n<p class=\"wp-block-paragraph\">\u306a\u304a\u3001MAOA 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class=\"wp-block-heading\">\u539f\u56e0<\/h2>\n\n\n<p class=\"wp-block-paragraph\"><strong>MAOA<\/strong> \u907a\u4f1d\u5b50\u306f\u3001<strong>\u30e2\u30ce\u30a2\u30df\u30f3\u9178\u5316\u9175\u7d20A\uff08MAO-A\uff09<\/strong>\u3068\u3044\u3046\u9175\u7d20\u306e\u8a2d\u8a08\u56f3\u3067\u3059\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\">\u8133\u306e\u795e\u7d4c\u7d30\u80de\u3069\u3046\u3057\u306f\u3001<strong>\u30bb\u30ed\u30c8\u30cb\u30f3\u3001\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u3001\u30c9\u30d1\u30df\u30f3<\/strong>\u3068\u3044\u3063\u305f\u300c\u30e2\u30ce\u30a2\u30df\u30f3\u300d\u3068\u547c\u3070\u308c\u308b\u7269\u8cea\u3092\u3084\u308a\u3068\u308a\u3057\u3066\u60c5\u5831\u3092\u4f1d\u3048\u3066\u3044\u307e\u3059\u3002MAO-A 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class=\"wp-block-paragraph\">\u75c7\u72b6\u306f\u4e3b\u306b\u7537\u6027\u306b\u73fe\u308c\u307e\u3059\u3002\u5831\u544a\u304c\u5c11\u306a\u3044\u305f\u3081\u3001<strong>\u540c\u3058\u5bb6\u7cfb\u306e\u306a\u304b\u3067\u3082\u7a0b\u5ea6\u306b\u306f\u5e45\u304c\u3042\u308a\u307e\u3059<\/strong>\u3002<\/p>\n\n\n<ul 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href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-spectrum-disorder-genetics\/\">\u81ea\u9589\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u75c7<\/a>\u3084\u6ce8\u610f\u6b20\u5982\u30fb\u591a\u52d5\u75c7\u306b\u4f3c\u305f\u7279\u5fb4\u304c\u307f\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n\n\n\n<li><strong>\u4f53\u3064\u304d\u3084\u9854\u3064\u304d\u306b\u76ee\u7acb\u3063\u305f\u7279\u5fb4\u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093<\/strong><\/li>\n\n\n<\/ul>\n\n\n<p 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class=\"wp-block-paragraph\">\u5c3f\u3084\u8840\u6db2\u306e\u691c\u67fb\u3067\u3001<strong>\u30e2\u30ce\u30a2\u30df\u30f3\u304c\u5206\u89e3\u3055\u308c\u3066\u3067\u304d\u308b\u7269\u8cea\u304c\u5c11\u306a\u304f\u3001\u5206\u89e3\u3055\u308c\u308b\u524d\u306e\u7269\u8cea\u304c\u591a\u3044<\/strong>\u3068\u3044\u3046\u7279\u5fb4\u7684\u306a\u30d1\u30bf\u30fc\u30f3\u304c\u307f\u3089\u308c\u3001\u8a3a\u65ad\u306e\u53c2\u8003\u306b\u306a\u308a\u307e\u3059\u3002\u78ba\u5b9a\u8a3a\u65ad\u306f<strong>\u907a\u4f1d\u5b66\u7684\u691c\u67fb<\/strong>\u3067\u884c\u3044\u3001<strong>MAOA<\/strong> \u907a\u4f1d\u5b50\u306e\u5909\u5316\u3092\u78ba\u8a8d\u3057\u307e\u3059\u3002<strong>\u304a\u6bcd\u3055\u307e\u304c\u30ad\u30e3\u30ea\u30a2\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u308b\u3053\u3068\u306f\u3001\u3054\u304d\u3087\u3046\u3060\u3044\u3084\u6b21\u306e\u304a\u5b50\u3055\u307e\u306e\u898b\u901a\u3057\u3092\u8003\u3048\u308b\u3046\u3048\u3067\u5927\u304d\u306a\u610f\u5473\u304c\u3042\u308a\u307e\u3059\u3002<\/strong><\/p>\n\n\n<h2 class=\"wp-block-heading\">\u6cbb\u7642<\/h2>\n\n\n<p class=\"wp-block-paragraph\"><strong>\u73fe\u6642\u70b9\u3067\u3001\u3053\u306e\u75c5\u6c17\u3092\u6839\u672c\u304b\u3089\u6cbb\u3059\u6cbb\u7642\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/strong>\u75c7\u72b6\u306b\u5408\u308f\u305b\u305f\u5bfe\u75c7\u7642\u6cd5\u3068\u3001<strong>\u3054\u672c\u4eba\u3068\u3054\u5bb6\u65cf\u3092\u9577\u304f\u652f\u3048\u308b\u4f53\u5236\u3065\u304f\u308a<\/strong>\u304c\u4e2d\u5fc3\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u767a\u9054\u3068\u5b66\u7fd2\u306e\u652f\u63f4<\/strong>\uff1a\u7642\u80b2\u3084\u7279\u5225\u652f\u63f4\u6559\u80b2\u306a\u3069\u3001\u3054\u672c\u4eba\u306b\u5408\u3063\u305f\u5b66\u3073\u306e\u5834\u3092\u6574\u3048\u307e\u3059<\/li>\n\n\n\n<li><strong>\u884c\u52d5\u3078\u306e\u652f\u63f4<\/strong>\uff1a\u6012\u308a\u3084\u30b9\u30c8\u30ec\u30b9\u3078\u306e\u5bfe\u51e6\u6cd5\u3092\u4e00\u7dd2\u306b\u8eab\u306b\u3064\u3051\u308b\u306a\u3069\u3001\u5fc3\u7406\u30fb\u884c\u52d5\u9762\u306e\u5c02\u9580\u7684\u306a\u652f\u63f4\u3092\u884c\u3044\u307e\u3059<\/li>\n\n\n\n<li><strong>\u304a\u85ac\u306e\u4f7f\u3044\u65b9\u3078\u306e\u6ce8\u610f<\/strong>\uff1a<strong>\u4e00\u90e8\u306e\u6297\u3046\u3064\u85ac\u306a\u3069\u3001\u30e2\u30ce\u30a2\u30df\u30f3\u3092\u5897\u3084\u3059\u306f\u305f\u3089\u304d\u306e\u304a\u85ac\u306f\u3001\u4f53\u306e\u306a\u304b\u3067\u30e2\u30ce\u30a2\u30df\u30f3\u304c\u591a\u304f\u306a\u308a\u3059\u304e\u308b\u304a\u305d\u308c\u304c\u3042\u308b\u305f\u3081\u3001\u614e\u91cd\u306b\u5224\u65ad\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059<\/strong>\u3002\u53d7\u8a3a\u306e\u969b\u306b\u306f\u8a3a\u65ad\u540d\u3092\u5fc5\u305a\u4f1d\u3048\u3066\u304f\u3060\u3055\u3044<\/li>\n\n\n\n<li><strong>\u98df\u4e8b\u306e\u5de5\u592b<\/strong>\uff1a\u719f\u6210\u3057\u305f\u30c1\u30fc\u30ba\u306a\u3069\u300c\u30c1\u30e9\u30df\u30f3\u300d\u3092\u591a\u304f\u542b\u3080\u98df\u54c1\u3092\u63a7\u3048\u308b\u3053\u3068\u304c\u52e7\u3081\u3089\u308c\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002\u4e3b\u6cbb\u533b\u3068\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044<\/li>\n\n\n\n<li><strong>\u7761\u7720\u306e\u6539\u5584<\/strong>\uff1a\u751f\u6d3b\u30ea\u30ba\u30e0\u3092\u6574\u3048\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u6cbb\u7642\u3092\u884c\u3044\u307e\u3059<\/li>\n\n\n\n<li><strong>\u3054\u5bb6\u65cf\u3078\u306e\u652f\u63f4<\/strong>\uff1a\u3054\u5bb6\u65cf\u3060\u3051\u3067\u62b1\u3048\u8fbc\u307e\u305a\u3001\u533b\u7642\u30fb\u6559\u80b2\u30fb\u798f\u7949\u306e\u7a93\u53e3\u3068\u9023\u643a\u3059\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059<\/li>\n\n\n<\/ul>\n\n\n<h2 class=\"wp-block-heading\">\u3053\u306e\u75be\u60a3\u306f\u691c\u67fb\u3067\u308f\u304b\u308a\u307e\u3059<\/h2>\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u75be\u60a3\u306f\u3001\u539f\u56e0\u3068\u306a\u308b <strong>MAOA<\/strong> \u907a\u4f1d\u5b50\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3001\u767a\u75c7\u524d\u3084\u51fa\u751f\u524d\u306b\u898b\u3064\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30afNIPT\u3067\u306f\u6b21\u306e\u691c\u67fb\u3092\u3054\u7528\u610f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">\u30a8\u30af\u30bd\u30fc\u30e0\u89e3\u6790\u3092\u7528\u3044\u305f\u691c\u67fb\uff081,200\u7a2e\u985e\u4ee5\u4e0a\uff09<\/h3>\n\n\n<p class=\"wp-block-paragraph\">\u30a8\u30af\u30bd\u30fc\u30e0\u89e3\u6790\u306f\u3001\u907a\u4f1d\u5b50\u306e\u3046\u3061\u305f\u3093\u3071\u304f\u8cea\u306e\u8a2d\u8a08\u56f3\u306b\u3042\u305f\u308b\u90e8\u5206\uff08\u30a8\u30af\u30bd\u30f3\uff09\u3092\u307e\u3068\u3081\u3066\u8aad\u307f\u53d6\u308b\u691c\u67fb\u3067\u3059\u3002\u3053\u306e\u89e3\u6790\u3092\u884c\u3063\u305f\u3046\u3048\u3067\u3001<strong>MAOA<\/strong> \u907a\u4f1d\u5b50\u3092\u542b\u3080<strong>1,200\u7a2e\u985e\u4ee5\u4e0a<\/strong>\u306e\u907a\u4f1d\u5b50\u3092\u5bfe\u8c61\u306b\u8abf\u3079\u3001<strong>\u3053\u306e\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u308b\u5909\u5316\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059<\/strong>\u3002\u56fd\u5185\u306e\u691c\u67fb\u6240\u3067\u884c\u3044\u3001\u7d50\u679c\u307e\u3067\u306e\u671f\u9593\u306f5\u9031\u9593\u301c7\u9031\u9593\u3067\u3059\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\">X\u9023\u9396\u6f5c\u6027\uff08\u52a3\u6027\uff09\u907a\u4f1d\u306e\u75be\u60a3\u306f\u3001\u304a\u6bcd\u3055\u307e\u304c\u75c7\u72b6\u306e\u306a\u3044\u300c\u30ad\u30e3\u30ea\u30a2\uff08\u4fdd\u56e0\u8005\uff09\u300d\u3067\u3042\u308b\u3068\u304d\u306b\u3001<strong>\u7537\u306e\u5b50\u3067\u306f2\u5206\u306e1\u306e\u78ba\u7387<\/strong>\u3067\u767a\u75c7\u3057\u3001\u5973\u306e\u5b50\u3067\u306f2\u5206\u306e1\u306e\u78ba\u7387\u3067\u304a\u6bcd\u3055\u307e\u3068\u540c\u3058\u30ad\u30e3\u30ea\u30a2\u3068\u306a\u308a\u307e\u3059\u3002\u691c\u67fb\u306e\u5185\u5bb9\u30fb\u8cbb\u7528\u30fb\u7d50\u679c\u307e\u3067\u306e\u671f\u9593\u306f <a href=\"\/nipt\/nipt\/carrier-screening-1200\/\">\u30ad\u30e3\u30ea\u30a2\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30c6\u30b9\u30c81,200\uff0b\u306e\u30da\u30fc\u30b8<\/a> \u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n<h2 class=\"wp-block-heading\">\u5c02\u9580\u7684\u306a\u89e3\u8aac<\/h2>\n\n\n<p class=\"wp-block-paragraph\"><strong>MAOA<\/strong>\uff08Xp11.3\uff09\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5916\u819c\u306b\u5c40\u5728\u3059\u308b<strong>\u30e2\u30ce\u30a2\u30df\u30f3\u9178\u5316\u9175\u7d20A<\/strong>\u3092\u30b3\u30fc\u30c9\u3057\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u30fb\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u30fb\u30c9\u30d1\u30df\u30f3\u306e\u9178\u5316\u7684\u8131\u30a2\u30df\u30ce\u5316\u3092\u62c5\u3046\u3002Brunner \u3089\u306f1993\u5e74\u3001\u30aa\u30e9\u30f3\u30c0\u306e\u5927\u5bb6\u7cfb\u3067<strong>\u5883\u754c\u57df\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/why-premium-plan\/\">\u77e5\u7684\u969c\u5bb3<\/a>\u3068\u885d\u52d5\u7684\u653b\u6483\u6027\u3092\u793a\u3059\u7f79\u60a3\u7537\u6027\u306b\u3001\u30a8\u30af\u30bd\u30f38\u306e\u30ca\u30f3\u30bb\u30f3\u30b9\u5909\u7570\uff08p.Gln296Ter\uff09\u306b\u3088\u308b MAO-A \u5b8c\u5168\u6b20\u640d<\/strong>\u3092\u540c\u5b9a\u3057\u305f\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u5316\u5b66\u7684\u306b\u306f\u3001\u5c3f\u4e2d\u30ce\u30eb\u30e1\u30bf\u30cd\u30d5\u30ea\u30f3\u30fb\u30bb\u30ed\u30c8\u30cb\u30f3\u306a\u3069\u57fa\u8cea\u5074\u4ee3\u8b1d\u7269\u306e\u4e0a\u6607\u3068\u30015-HIAA\u30fbVMA\u30fbHVA \u306a\u3069\u8131\u30a2\u30df\u30ce\u5316\u7523\u7269\u306e\u4f4e\u4e0b<\/strong>\u304c\u7279\u5fb4\u3067\u3001\u8840\u4e2d\u30bb\u30ed\u30c8\u30cb\u30f3\u9ad8\u5024\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u305d\u306e\u5f8c\u30012014\u5e74\u4ee5\u964d\u306b\u30df\u30b9\u30bb\u30f3\u30b9\u5909\u7570\u306b\u3088\u308b\u8907\u6570\u5bb6\u7cfb\u304c\u5831\u544a\u3055\u308c\u3001<strong>\u81ea\u9589\u7684\u7279\u5fb4\u3001\u7761\u7720\u969c\u5bb3\u3001\u767a\u4f5c\u6027\u306e\u7d05\u6f6e<\/strong>\u306a\u3069\u306e\u8868\u73fe\u578b\u306e\u5e83\u304c\u308a\u304c\u793a\u3055\u308c\u305f\u3002<strong>\u30bb\u30ed\u30c8\u30cb\u30f3\u75c7\u5019\u7fa4\u69d8\u306e\u75c5\u614b\u304c\u60f3\u5b9a\u3055\u308c\u308b\u3053\u3068\u304b\u3089\u3001\u4f4e\u30c1\u30e9\u30df\u30f3\u98df\u3084\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u4f5c\u52d5\u85ac\u30fbMAO\u963b\u5bb3\u85ac\u306e\u56de\u907f\u304c\u63d0\u6848\u3055\u308c\u3066\u3044\u308b<\/strong>\u304c\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u75c7\u4f8b\u5831\u544a\u30ec\u30d9\u30eb\u306b\u3068\u3069\u307e\u308b\u3002\u4fdd\u56e0\u5973\u6027\u306f\u4e00\u822c\u306b\u7121\u75c7\u72b6\u3067\u3042\u308b\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\"><strong>\u672c\u75c7\u306f\u3001\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u306e\u53cd\u5fa9\u914d\u5217\u591a\u578b\uff08MAOA-uVNTR\uff09\u306b\u3088\u308b\u6d3b\u6027\u306e\u500b\u4eba\u5dee\u3068\u306f\u660e\u78ba\u306b\u533a\u5225\u3055\u308c\u308b\u3002<\/strong>uVNTR \u306f\u96c6\u56e3\u5185\u3067\u3042\u308a\u3075\u308c\u305f\u591a\u578b\u3067\u3001\u74b0\u5883\u8981\u56e0\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u5358\u72ec\u3067\u75be\u60a3\u3092\u5f15\u304d\u8d77\u3053\u3059\u3082\u306e\u3067\u306f\u306a\u3044\u3002\u307e\u305f\u3001<em>MAOA<\/em>\u30fb<em>MAOB<\/em>\u30fb<em>NDP<\/em> \u3092\u542b\u3080 Xp11.3 \u306e\u6b20\u5931\u306f\u3001\u30ce\u30ea\u30a8\u75c5\u306b\u91cd\u5ea6<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/why-premium-plan\/\">\u77e5\u7684\u969c\u5bb3<\/a>\u3092\u4f34\u3046\u96a3\u63a5\u907a\u4f1d\u5b50\u75c7\u5019\u7fa4\u3068\u306a\u308a\u3001\u672c\u75c7\u3068\u306f\u81e8\u5e8a\u50cf\u304c\u7570\u306a\u308b\u3002\u9451\u5225\u3068\u3057\u3066\u306f\u3001\u4ed6\u306e X \u9023\u9396<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/why-premium-plan\/\">\u77e5\u7684\u969c\u5bb3<\/a>\u3084\u3001\u30e2\u30ce\u30a2\u30df\u30f3\u4ee3\u8b1d\u7570\u5e38\u75c7\uff08\u82b3\u9999\u65cfL-\u30a2\u30df\u30ce\u9178\u8131\u70ad\u9178\u9175\u7d20\u6b20\u640d\u75c7\u306a\u3069\uff09\u304c\u6319\u304c\u308a\u3001<strong>\u5c3f\u4e2d\u30e2\u30ce\u30a2\u30df\u30f3\u4ee3\u8b1d\u7269\u306e\u6e2c\u5b9a\u3068\u907a\u4f1d\u5b50\u89e3\u6790\u304c\u8a3a\u65ad\u306b\u6709\u7528\u3067\u3042\u308b\u3002<\/strong><\/p>\n\n\n<h2 class=\"wp-block-heading\">\u3088\u304f\u3042\u308b\u8cea\u554f<\/h2>\n\n\n<h3 class=\"wp-block-heading\">Q. \u6b21\u306e\u304a\u5b50\u3055\u307e\u3078\u306e\u5f71\u97ff\u306f\u3042\u308a\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u3053\u306e\u75c5\u6c17\u306f X \u9023\u9396\u6f5c\u6027\u907a\u4f1d\u306e\u305f\u3081\u3001\u304a\u6bcd\u3055\u307e\u304c\u30ad\u30e3\u30ea\u30a2\u306e\u5834\u5408\u3001\u7537\u306e\u5b50\u3067\u306f2\u5206\u306e1\u306e\u78ba\u7387\u3067\u767a\u75c7\u3057\u3001\u5973\u306e\u5b50\u3067\u306f2\u5206\u306e1\u306e\u78ba\u7387\u3067\u30ad\u30e3\u30ea\u30a2\u3068\u306a\u308a\u307e\u3059\u3002<\/strong>\u307e\u308c\u306b\u3001\u304a\u6bcd\u3055\u307e\u306f\u30ad\u30e3\u30ea\u30a2\u3067\u306f\u306a\u304f\u3001\u304a\u5b50\u3055\u307e\u306b\u65b0\u305f\u306b\u907a\u4f1d\u5b50\u306e\u5909\u5316\u304c\u8d77\u304d\u3066\u3044\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<strong>\u304a\u6bcd\u3055\u307e\u304c\u30ad\u30e3\u30ea\u30a2\u304b\u3069\u3046\u304b\u3067\u898b\u901a\u3057\u304c\u5927\u304d\u304f\u7570\u306a\u308b\u305f\u3081\u3001\u907a\u4f1d\u5b66\u7684\u691c\u67fb\u3067\u78ba\u8a8d\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/strong><\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u598a\u5a20\u4e2d\u306b\u5206\u304b\u308a\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u3053\u306e\u75c5\u6c17\u306f\u4f53\u306e\u5f62\u306e\u7570\u5e38\u3092\u3068\u3082\u306a\u308f\u306a\u3044\u305f\u3081\u3001\u598a\u5a20\u4e2d\u306e\u8d85\u97f3\u6ce2\u691c\u67fb\u3067\u6c17\u3065\u304b\u308c\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/strong>\u3054\u5bb6\u65cf\u306b\u8a3a\u65ad\u304c\u3064\u3044\u3066\u3044\u308b\u5834\u5408\u3084\u3001\u304a\u6bcd\u3055\u307e\u304c\u30ad\u30e3\u30ea\u30a2\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u308b\u5834\u5408\u306f\u3001\u907a\u4f1d\u5b66\u7684\u691c\u67fb\u3092\u691c\u8a0e\u3067\u304d\u307e\u3059\u3002\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u300c\u653b\u6483\u6027\u306e\u907a\u4f1d\u5b50\u300d\u3068\u805e\u3044\u3066\u5fc3\u914d\u3067\u3059\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. MAOA \u907a\u4f1d\u5b50\u306b\u306f\u3001\u591a\u304f\u306e\u4eba\u304c\u3082\u3064\u3088\u304f\u3042\u308b\u500b\u4eba\u5dee\u304c\u3042\u308a\u3001\u8a71\u984c\u3068\u3057\u3066\u53d6\u308a\u4e0a\u3052\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<strong>\u30d6\u30eb\u30f3\u30ca\u30fc\u75c7\u5019\u7fa4\u306f\u3001\u9175\u7d20\u306e\u306f\u305f\u3089\u304d\u304c\u5b8c\u5168\u306b\u5931\u308f\u308c\u308b\u304d\u308f\u3081\u3066\u307e\u308c\u306a\u75c5\u6c17\u3067\u3001\u3053\u3046\u3057\u305f\u500b\u4eba\u5dee\u3068\u306f\u5225\u306e\u3082\u306e\u3067\u3059\u3002<\/strong>\u307e\u305f\u3001\u3053\u306e\u75c5\u6c17\u3067\u3042\u3063\u3066\u3082\u884c\u52d5\u306f\u74b0\u5883\u3084\u652f\u63f4\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u5909\u308f\u308a\u3001<strong>\u907a\u4f1d\u5b50\u3060\u3051\u3067\u4eba\u306e\u884c\u52d5\u304c\u6c7a\u307e\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/strong><\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u30ad\u30e3\u30ea\u30a2\u306e\u5973\u6027\u306b\u75c7\u72b6\u306f\u51fa\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u3053\u308c\u307e\u3067\u306e\u5831\u544a\u3067\u306f\u3001\u30ad\u30e3\u30ea\u30a2\u306e\u5973\u6027\u306f\u901a\u5e38\u306f\u75c7\u72b6\u304c\u3042\u308a\u307e\u305b\u3093\u3002<\/strong>\u3082\u30461\u672c\u306e X \u67d3\u8272\u4f53\u306b\u3042\u308b\u907a\u4f1d\u5b50\u304c\u306f\u305f\u3089\u304d\u3092\u88dc\u3046\u305f\u3081\u3067\u3059\u3002\u305f\u3060\u3057\u5831\u544a\u6570\u304c\u5c11\u306a\u3044\u305f\u3081\u3001\u6c17\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308c\u3070\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067\u306f\u4f55\u3092\u76f8\u8ac7\u3067\u304d\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. \u8a3a\u65ad\u306e\u610f\u5473\u3001\u6b21\u306e\u304a\u5b50\u3055\u307e\u3078\u306e\u5f71\u97ff\u3001\u51fa\u751f\u524d\u691c\u67fb\u3084\u7740\u5e8a\u524d\u691c\u67fb\u306e\u9078\u629e\u80a2\u3001\u3054\u304d\u3087\u3046\u3060\u3044\u3084\u3054\u89aa\u65cf\u3078\u306e\u5f71\u97ff\u306a\u3069\u3092\u3054\u76f8\u8ac7\u3044\u305f\u3060\u3051\u307e\u3059\u3002\u5224\u65ad\u3092\u6025\u304c\u305b\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n<h2 class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e<\/h2>\n\n\n<ul class=\"wp-block-list\">\n<li>Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. <em>Science<\/em>. 1993;262(5133):578-580.<\/li>\n\n\n\n<li>Brunner HG, Nelen MR, van Zandvoort P, et al. X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism. <em>Am J Hum Genet<\/em>. 1993;52(6):1032-1039.<\/li>\n\n\n\n<li>Piton A, Poquet H, Redin C, et al. 20 ans apr\u00e8s: a second mutation in MAOA identified by targeted high-throughput sequencing in a family with altered behavior and cognition. <em>Eur J Hum Genet<\/em>. 2014;22(6):776-783.<\/li>\n\n\n\n<li>Palmer EE, Leffler M, Rogers C, et al. New insights into Brunner syndrome and potential for targeted therapy. <em>Clin Genet<\/em>. 2016;89(1):120-127.<\/li>\n\n\n\n<li>OMIM #300615 Brunner syndrome. Online Mendelian Inheritance in Man.<\/li>\n\n\n<\/ul>\n","protected":false},"featured_media":0,"menu_order":0,"template":"page_gd.php","class_list":["post-147755","genetic-diseases","type-genetic-diseases","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/147755","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/genetic-diseases"}],"version-history":[{"count":0,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/147755\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=147755"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}