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class=\"wp-block-paragraph\">\u78ba\u5b9a\u8a3a\u65ad\u306f<strong>\u907a\u4f1d\u5b66\u7684\u691c\u67fb<\/strong>\u3067\u884c\u3044\u3001\u30bb\u30ca\u30cb\u30fb\u30ec\u30f3\u30c4\u5408\u6307\u75c7\u75c7\u5019\u7fa4\u3067\u306f <strong>LRP4<\/strong> \u907a\u4f1d\u5b50\u306b\u7236\u65b9\u30fb\u6bcd\u65b9\u305d\u308c\u305e\u308c\u7531\u6765\u306e\u5909\u5316\u304c\u898b\u3064\u304b\u308a\u307e\u3059\u3002<strong>\u3088\u304f\u4f3c\u305f\u624b\u306e\u5f62\u3092\u793a\u3059\u75c5\u6c17\u306b\u306f\u3001\u907a\u4f1d\u306e\u3057\u304b\u305f\u304c\u7570\u306a\u308b\u3082\u306e\u3082\u3042\u308b\u305f\u3081\u3001\u6b21\u306e\u304a\u5b50\u3055\u307e\u306e\u898b\u901a\u3057\u3092\u6b63\u3057\u304f\u304a\u4f1d\u3048\u3059\u308b\u3046\u3048\u3067\u3001\u539f\u56e0\u907a\u4f1d\u5b50\u3092\u78ba\u5b9a\u3059\u308b\u3053\u3068\u306b\u306f\u5927\u304d\u306a\u610f\u5473\u304c\u3042\u308a\u307e\u3059\u3002<\/strong><\/p>\n\n\n<h2 class=\"wp-block-heading\">\u6cbb\u7642<\/h2>\n\n\n<p class=\"wp-block-paragraph\"><strong>\u73fe\u6642\u70b9\u3067\u3001\u907a\u4f1d\u5b50\u306e\u5909\u5316\u305d\u306e\u3082\u306e\u3092\u6cbb\u3059\u6cbb\u7642\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/strong>\u6cbb\u7642\u306f\u3001<strong>\u624b\u306e\u6a5f\u80fd\u3092\u3067\u304d\u308b\u3060\u3051\u5f15\u304d\u51fa\u3059\u3053\u3068\u3068\u3001\u814e\u81d3\u306e\u72b6\u614b\u3092\u898b\u5b88\u308b\u3053\u3068\u304c\u4e2d\u5fc3<\/strong>\u306b\u306a\u308a\u307e\u3059\u3002\u6574\u5f62\u5916\u79d1\uff08\u624b\u306e\u5916\u79d1\uff09\u3001\u814e\u81d3\u5185\u79d1\u30fb\u6ccc\u5c3f\u5668\u79d1\u3001\u30ea\u30cf\u30d3\u30ea\u30c6\u30fc\u30b7\u30e7\u30f3\u79d1\u306a\u3069\u304c\u5354\u529b\u3057\u3066\u652f\u3048\u307e\u3059\u3002<\/p>\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u624b\u306e\u5916\u79d1\u624b\u8853<\/strong>\uff1a\u7652\u5408\u3057\u305f\u6307\u3092\u5206\u3051\u308b\u624b\u8853\u3092\u691c\u8a0e\u3057\u307e\u3059\u3002\u305f\u3060\u3057\u9aa8\u3054\u3068\u7652\u5408\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u591a\u3044\u305f\u3081\u3001<strong>\u898b\u305f\u76ee\u3084\u6a5f\u80fd\u306e\u6539\u5584\u306b\u306f\u9650\u754c\u304c\u3042\u308a\u3001\u624b\u8853\u306e\u6642\u671f\u3084\u65b9\u6cd5\u306f\u500b\u5225\u306b\u5224\u65ad\u3057\u307e\u3059<\/strong><\/li>\n\n\n\n<li><strong>\u4f5c\u696d\u7642\u6cd5\u30fb\u30ea\u30cf\u30d3\u30ea\u30c6\u30fc\u30b7\u30e7\u30f3<\/strong>\uff1a\u3064\u304b\u3080\u30fb\u6301\u3064\u306a\u3069\u3001\u65e5\u5e38\u751f\u6d3b\u306e\u52d5\u4f5c\u3092\u5de5\u592b\u3057\u3066\u8eab\u306b\u3064\u3051\u308b\u652f\u63f4<\/li>\n\n\n\n<li><strong>\u814e\u81d3\u306e\u8a55\u4fa1\u3068\u5b9a\u671f\u7684\u306a\u7d4c\u904e\u89b3\u5bdf<\/strong>\uff1a\u814e\u6a5f\u80fd\u3084\u8840\u5727\u3092\u78ba\u8a8d\u3057\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u6cbb\u7642\u3092\u884c\u3044\u307e\u3059<\/li>\n\n\n\n<li>\u6b6f\u79d1\u3067\u306e\u5b9a\u671f\u7684\u306a\u8a3a\u5bdf<\/li>\n\n\n\n<li><strong>\u5712\u30fb\u5b66\u6821\u751f\u6d3b\u3084\u5fc3\u7406\u9762\u306e\u652f\u63f4<\/strong>\uff1a\u9053\u5177\u306e\u5de5\u592b\u3084\u5468\u56f2\u306e\u7406\u89e3\u3092\u542b\u3081\u305f\u7d99\u7d9a\u7684\u306a\u652f\u3048<\/li>\n\n\n<\/ul>\n\n\n<h2 class=\"wp-block-heading\">\u3053\u306e\u75be\u60a3\u306f\u691c\u67fb\u3067\u308f\u304b\u308a\u307e\u3059<\/h2>\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u75be\u60a3\u306f\u3001\u539f\u56e0\u3068\u306a\u308b <strong>LRP4<\/strong> \u907a\u4f1d\u5b50\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3001\u767a\u75c7\u524d\u3084\u51fa\u751f\u524d\u306b\u898b\u3064\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30afNIPT\u3067\u306f\u6b21\u306e\u691c\u67fb\u3092\u3054\u7528\u610f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">\u30a8\u30af\u30bd\u30fc\u30e0\u89e3\u6790\u3092\u7528\u3044\u305f\u691c\u67fb\uff081,200\u7a2e\u985e\u4ee5\u4e0a\uff09<\/h3>\n\n\n<p class=\"wp-block-paragraph\">\u30a8\u30af\u30bd\u30fc\u30e0\u89e3\u6790\u306f\u3001\u907a\u4f1d\u5b50\u306e\u3046\u3061\u305f\u3093\u3071\u304f\u8cea\u306e\u8a2d\u8a08\u56f3\u306b\u3042\u305f\u308b\u90e8\u5206\uff08\u30a8\u30af\u30bd\u30f3\uff09\u3092\u307e\u3068\u3081\u3066\u8aad\u307f\u53d6\u308b\u691c\u67fb\u3067\u3059\u3002\u3053\u306e\u89e3\u6790\u3092\u884c\u3063\u305f\u3046\u3048\u3067\u3001<strong>LRP4<\/strong> \u907a\u4f1d\u5b50\u3092\u542b\u3080<strong>1,200\u7a2e\u985e\u4ee5\u4e0a<\/strong>\u306e\u907a\u4f1d\u5b50\u3092\u5bfe\u8c61\u306b\u8abf\u3079\u3001<strong>\u3053\u306e\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u308b\u5909\u5316\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059<\/strong>\u3002\u56fd\u5185\u306e\u691c\u67fb\u6240\u3067\u884c\u3044\u3001\u7d50\u679c\u307e\u3067\u306e\u671f\u9593\u306f5\u9031\u9593\u301c7\u9031\u9593\u3067\u3059\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u75be\u60a3\u306f\u5e38\u67d3\u8272\u4f53\u6f5c\u6027\uff08\u52a3\u6027\uff09\u907a\u4f1d\u306e\u305f\u3081\u3001\u3054\u4e21\u89aa\u304c\u3069\u3061\u3089\u3082\u75c7\u72b6\u306e\u306a\u3044\u300c\u30ad\u30e3\u30ea\u30a2\uff08\u4fdd\u56e0\u8005\uff09\u300d\u3067\u3042\u308b\u3068\u304d\u306b\u3001<strong>\u304a\u5b50\u3055\u307e\u3054\u3068\u306b4\u5206\u306e1\u306e\u78ba\u7387<\/strong>\u3067\u767a\u75c7\u3057\u307e\u3059\u3002\u691c\u67fb\u306e\u5185\u5bb9\u30fb\u8cbb\u7528\u30fb\u7d50\u679c\u307e\u3067\u306e\u671f\u9593\u306f <a href=\"\/nipt\/nipt\/carrier-screening-1200\/\">\u30ad\u30e3\u30ea\u30a2\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30c6\u30b9\u30c81,200\uff0b\u306e\u30da\u30fc\u30b8<\/a> \u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n<h2 class=\"wp-block-heading\">\u5c02\u9580\u7684\u306a\u89e3\u8aac<\/h2>\n\n\n<p class=\"wp-block-paragraph\"><strong>LRP4<\/strong>\uff08low-density lipoprotein receptor-related protein 4\uff09\u306f LDL \u53d7\u5bb9\u4f53\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3059\u308b1\u56de\u819c\u8cab\u901a\u578b\u53d7\u5bb9\u4f53\u3067\u3001\u7d30\u80de\u5916\u306b4\u3064\u306e\u03b2\u30d7\u30ed\u30da\u30e9\u30c9\u30e1\u30a4\u30f3\u3092\u3082\u3064\u3002<strong>\u30b9\u30af\u30ec\u30ed\u30b9\u30c1\u30f3\uff08SOST\uff09\u3084 DKK1 \u3068\u7d50\u5408\u3057\u3066 LRP5\/6 \u3092\u4ecb\u3059\u308b Wnt\/\u03b2\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u3092\u6291\u5236\u3059\u308b\u88dc\u52a9\u53d7\u5bb9\u4f53<\/strong>\u3068\u3057\u3066\u306f\u305f\u3089\u304f\u307b\u304b\u3001\u795e\u7d4c\u7b4b\u63a5\u5408\u90e8\u3067\u306f<strong>\u30a2\u30b0\u30ea\u30f3\u306e\u53d7\u5bb9\u4f53\u3068\u3057\u3066 MuSK \u3092\u6d3b\u6027\u5316\u3057\u3001\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u53d7\u5bb9\u4f53\u306e\u96c6\u7a4d\u3092\u62c5\u3046<\/strong>\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\">Li \u3089\u306f\u30bb\u30ca\u30cb\u30fb\u30ec\u30f3\u30c4\u5408\u6307\u75c7\u75c7\u5019\u7fa4\u306e\u5bb6\u7cfb\u3067 LRP4 \u306e\u4e21\u30a2\u30ec\u30eb\u5909\u7570\u3092\u540c\u5b9a\u3057\u3001<strong>\u5909\u7570\u578b LRP4 \u304c LRP6 \u3092\u4ecb\u3057\u305f Wnt \u30b7\u30b0\u30ca\u30eb\u3092\u5341\u5206\u306b\u6291\u5236\u3067\u304d\u306a\u3044\u3053\u3068<\/strong>\u3092\u793a\u3057\u305f\u3002\u80a2\u82bd\u306e\u5916\u80da\u8449\u6027\u9802\u5824\uff08AER\uff09\u306b\u304a\u3051\u308b Wnt \u30b7\u30b0\u30ca\u30eb\u306e\u904e\u5270\u304c\u3001\u6307\u653e\u7dda\u306e\u5206\u96e2\u4e0d\u5168\u3068\u9aa8\u306e\u7652\u5408\u30fb\u914d\u5217\u7570\u5e38\u3092\u3082\u305f\u3089\u3059\u3068\u8003\u3048\u3089\u308c\u308b\u3002<strong>\u814e\u7121\u5f62\u6210\u30fb\u4f4e\u5f62\u6210\u306e\u5408\u4f75\u3082\u540c\u3058\u6a5f\u5e8f\u3067\u8aac\u660e\u3055\u308c\u3001\u814e\u75c5\u5909\u306e\u6709\u7121\u3068\u7a0b\u5ea6\u304c\u751f\u547d\u4e88\u5f8c\u3092\u898f\u5b9a\u3059\u308b<\/strong>\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\"><strong>\u672c\u907a\u4f1d\u5b50\u306f\u6a5f\u80fd\u306e\u7570\u306a\u308b\u8907\u6570\u306e\u8868\u73fe\u578b\u3092\u793a\u3059<\/strong>\u2014\u2014\u2460\u30bb\u30ca\u30cb\u30fb\u30ec\u30f3\u30c4\u5408\u6307\u75c7\u75c7\u5019\u7fa4\uff08\u5e38\u67d3\u8272\u4f53\u6f5c\u6027\u3001\u80a2\u30fb\u814e\u306e\u5f62\u614b\u5f62\u6210\u7570\u5e38\uff09\u3001\u2461\u786c\u7d50\u6027\u9aa8\u5316\u75c72\u578b\uff08\u4e3b\u306b\u7b2c3\u03b2\u30d7\u30ed\u30da\u30e9\u306e\u30df\u30b9\u30bb\u30f3\u30b9\u5909\u7570\u3067\u30b9\u30af\u30ec\u30ed\u30b9\u30c1\u30f3\u306e\u4fc3\u9032\u56e0\u5b50\u6a5f\u80fd\u304c\u640d\u306a\u308f\u308c\u3001\u9aa8\u91cf\u304c\u5897\u52a0\uff09\u3001\u2462\u5148\u5929\u6027\u7b4b\u7121\u529b\u75c7\u5019\u7fa417\u578b\uff08\u5e38\u67d3\u8272\u4f53\u6f5c\u6027\u3001\u30a2\u30b0\u30ea\u30f3\u2013MuSK \u30b7\u30b0\u30ca\u30eb\u306e\u969c\u5bb3\uff09\u3002<strong>\u540c\u3058\u907a\u4f1d\u5b50\u3067\u3082\u3001\u5909\u7570\u306e\u90e8\u4f4d\u3068\u5f71\u97ff\u3092\u53d7\u3051\u308b\u6a5f\u80fd\u306b\u3088\u3063\u3066\u81e8\u5e8a\u50cf\u304c\u307e\u3063\u305f\u304f\u7570\u306a\u308b\u305f\u3081\u3001\u5909\u7570\u306e\u89e3\u91c8\u306b\u306f\u8868\u73fe\u578b\u3068\u306e\u7167\u5408\u304c\u6b20\u304b\u305b\u306a\u3044<\/strong>\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\">\u9451\u5225\u3068\u3057\u3066\u306f\u300115q13.3 \u306e <em>GREM1<\/em>\u30fb<em>FMN1<\/em> \u9818\u57df\u306e\u5fae\u7d30\u91cd\u8907\u306b\u3088\u308b\u30bb\u30ca\u30cb\u30fb\u30ec\u30f3\u30c4\u69d8\u5408\u6307\u75c7\uff08\u5e38\u67d3\u8272\u4f53\u9855\u6027\uff09\u3001\u4ed6\u306e\u578b\u306e\u5408\u6307\u75c7\u3001\u6a48\u5c3a\u9aa8\u7652\u5408\u75c7\u306a\u3069\u304c\u6319\u304c\u308b\u3002<strong>\u907a\u4f1d\u5f62\u5f0f\u304c\u7570\u306a\u308b\u3068\u6b21\u5b50\u518d\u767a\u7387\u304c\u5927\u304d\u304f\u5909\u308f\u308b\u305f\u3081\u3001\u907a\u4f1d\u5b50\u8a3a\u65ad\u306f\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306b\u76f4\u7d50\u3059\u308b\u3002<\/strong><\/p>\n\n\n<h2 class=\"wp-block-heading\">\u3088\u304f\u3042\u308b\u8cea\u554f<\/h2>\n\n\n<h3 class=\"wp-block-heading\">Q. \u6b21\u306e\u304a\u5b50\u3055\u307e\u3078\u306e\u5f71\u97ff\u306f\u3042\u308a\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u3053\u306e\u75c5\u6c17\u306f\u5e38\u67d3\u8272\u4f53\u6f5c\u6027\u907a\u4f1d\u306e\u305f\u3081\u3001\u3054\u4e21\u89aa\u304c\u3069\u3061\u3089\u3082\u30ad\u30e3\u30ea\u30a2\u306e\u5834\u5408\u3001\u304a\u5b50\u3055\u307e\u3054\u3068\u306b4\u5206\u306e1\u306e\u78ba\u7387\u3067\u767a\u75c7\u3057\u307e\u3059\u3002<\/strong>\u3088\u304f\u4f3c\u305f\u624b\u306e\u5f62\u3092\u793a\u3059\u75c5\u6c17\u306b\u306f\u3001\u907a\u4f1d\u306e\u3057\u304b\u305f\u304c\u7570\u306a\u308b\u3082\u306e\u3082\u3042\u308a\u307e\u3059\u3002<strong>\u518d\u767a\u7387\u304c\u5927\u304d\u304f\u7570\u306a\u308b\u305f\u3081\u3001\u539f\u56e0\u907a\u4f1d\u5b50\u3092\u78ba\u5b9a\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/strong><\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u598a\u5a20\u4e2d\u306b\u5206\u304b\u308a\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u6307\u306e\u7652\u5408\u306f\u8d85\u97f3\u6ce2\u691c\u67fb\u3067\u898b\u5206\u3051\u306b\u304f\u3044\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u524d\u8155\u306e\u77ed\u7e2e\u3084\u814e\u81d3\u306e\u7570\u5e38\u3001\u7f8a\u6c34\u306e\u5c11\u306a\u3055\u304b\u3089\u6c17\u3065\u304b\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/strong>\u524d\u306e\u304a\u5b50\u3055\u307e\u3067\u539f\u56e0\u907a\u4f1d\u5b50\u304c\u308f\u304b\u3063\u3066\u3044\u308b\u5834\u5408\u306f\u3001\u598a\u5a20\u65e9\u671f\u304b\u3089\u306e\u691c\u67fb\u3092\u691c\u8a0e\u3067\u304d\u307e\u3059\u3002\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u540c\u3058\u907a\u4f1d\u5b50\u3067\u5225\u306e\u75c5\u6c17\u3082\u3042\u308b\u3068\u805e\u304d\u307e\u3057\u305f\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. \u306f\u3044\u3002<strong>LRP4 \u907a\u4f1d\u5b50\u306e\u5909\u5316\u306f\u3001\u9aa8\u304c\u539a\u304f\u786c\u304f\u306a\u308b\u75c5\u6c17\u3084\u3001\u7b4b\u8089\u304c\u75b2\u308c\u3084\u3059\u304f\u306a\u308b\u75c5\u6c17\u306e\u539f\u56e0\u306b\u3082\u306a\u308a\u307e\u3059\u3002<\/strong>\u3069\u306e\u75c5\u6c17\u306b\u306a\u308b\u304b\u306f\u3001\u5909\u5316\u306e\u5834\u6240\u3084\u7a2e\u985e\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002\u30bb\u30ca\u30cb\u30fb\u30ec\u30f3\u30c4\u5408\u6307\u75c7\u75c7\u5019\u7fa4\u306f\u3001\u624b\u8db3\u3068\u814e\u81d3\u306e\u3064\u304f\u3089\u308c\u65b9\u306b\u5f71\u97ff\u3059\u308b\u70b9\u304c\u7279\u5fb4\u3067\u3059\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u751f\u307e\u308c\u305f\u3042\u3068\u306e\u66ae\u3089\u3057\u306f\u3069\u3046\u306a\u308a\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. <strong>\u77e5\u7684\u306a\u767a\u9054\u306f\u591a\u304f\u306e\u5834\u5408\u4fdd\u305f\u308c\u3001\u624b\u306e\u4f7f\u3044\u65b9\u3092\u5de5\u592b\u3057\u306a\u304c\u3089\u5b66\u6821\u751f\u6d3b\u3084\u65e5\u5e38\u751f\u6d3b\u3092\u9001\u3063\u3066\u3044\u308b\u65b9\u3082\u3044\u307e\u3059\u3002<\/strong>\u4e00\u65b9\u3067\u3001\u4e21\u65b9\u306e\u814e\u81d3\u304c\u3064\u304f\u3089\u308c\u306a\u3044\u5834\u5408\u306f\u3001\u751f\u307e\u308c\u305f\u3042\u3068\u306b\u547d\u3092\u4fdd\u3064\u3053\u3068\u304c\u96e3\u3057\u304f\u306a\u308a\u307e\u3059\u3002<strong>\u898b\u901a\u3057\u306f\u814e\u81d3\u306e\u72b6\u614b\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u5909\u308f\u308b\u305f\u3081\u3001\u533b\u7642\u30c1\u30fc\u30e0\u3068\u3088\u304f\u8a71\u3057\u5408\u3063\u3066\u304f\u3060\u3055\u3044\u3002<\/strong><\/p>\n\n\n<h3 class=\"wp-block-heading\">Q. \u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067\u306f\u4f55\u3092\u76f8\u8ac7\u3067\u304d\u307e\u3059\u304b\u3002<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A. \u8a3a\u65ad\u306e\u610f\u5473\u3001\u6b21\u306e\u304a\u5b50\u3055\u307e\u3078\u306e\u5f71\u97ff\u3001\u51fa\u751f\u524d\u691c\u67fb\u3084\u7740\u5e8a\u524d\u691c\u67fb\u306e\u9078\u629e\u80a2\u3001\u3054\u304d\u3087\u3046\u3060\u3044\u3084\u3054\u89aa\u65cf\u3078\u306e\u5f71\u97ff\u306a\u3069\u3092\u3054\u76f8\u8ac7\u3044\u305f\u3060\u3051\u307e\u3059\u3002\u5224\u65ad\u3092\u6025\u304c\u305b\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n<h2 class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e<\/h2>\n\n\n<ul class=\"wp-block-list\">\n<li>Li Y, Pawlik B, Elcioglu N, et al. LRP4 mutations alter Wnt\/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome. <em>Am J Hum Genet<\/em>. 2010;86(5):696-706.<\/li>\n\n\n\n<li>Leupin O, Piters E, Halleux C, et al. Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function. <em>J Biol Chem<\/em>. 2011;286(22):19489-19500.<\/li>\n\n\n\n<li>Ohkawara B, Cabrera-Serrano M, Nakata T, et al. LRP4 third \u03b2-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated MuSK signaling in a position-specific manner. <em>Hum Mol Genet<\/em>. 2014;23(7):1856-1868.<\/li>\n\n\n\n<li>OMIM #212780 Cenani-Lenz Syndactyly Syndrome; CLSS. Online Mendelian Inheritance in Man.<\/li>\n\n\n\n<li>OMIM #614305 Sclerosteosis 2; SOST2. Online Mendelian Inheritance in Man.<\/li>\n\n\n\n<li>OMIM #616304 Myasthenic Syndrome, Congenital, 17; CMS17. Online Mendelian Inheritance in Man.<\/li>\n\n\n<\/ul>\n","protected":false},"featured_media":0,"menu_order":0,"template":"page_gd.php","class_list":["post-147783","genetic-diseases","type-genetic-diseases","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/147783","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/genetic-diseases"}],"version-history":[{"count":0,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/147783\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=147783"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}