{"id":33709,"date":"2022-07-12T13:27:19","date_gmt":"2022-07-12T04:27:19","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/?page_id=33709"},"modified":"2026-04-28T12:43:32","modified_gmt":"2026-04-28T03:43:32","slug":"homocystinuria-type-cble","status":"publish","type":"genetic-diseases","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/genetic-diseases2\/homocystinuria-type-cble\/","title":{"rendered":"\u30db\u30e2\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7cblE\u578b"},"content":{"rendered":"\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"has-text-align-center\"><sup>\u30db\u30e2\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u30fb\u5de8\u8d64\u82bd\u7403\u6027\u8ca7\u8840 cblE \u578b\uff08HMAE\uff09\u306f\u3001\u30d3\u30bf\u30df\u30f3B12\uff08\u30b3\u30d0\u30e9\u30df\u30f3\uff09\u4f9d\u5b58\u306e\u4ee3\u8b1d\u7d4c\u8def\u306e\u7570\u5e38\u306b\u3088\u308a\u767a\u75c7\u3059\u308b\u5e0c\u5c11\u306a\u5148\u5929\u6027\u4ee3\u8b1d\u7570\u5e38\u75c7\u3067\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001HMAE\u306e\u539f\u56e0\u907a\u4f1d\u5b50MTRR\u3001\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u3001\u8a3a\u65ad\u65b9\u6cd5\u3001\u75c7\u72b6\u3001\u6cbb\u7642\u6cd5\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u3001\u65e9\u671f\u8a3a\u65ad\u306e\u91cd\u8981\u6027\u3092\u8003\u5bdf\u3057\u307e\u3059\u3002<\/sup><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u907a\u4f1d\u5b50\u30fb\u75be\u60a3\u540d<\/h2>\n\n\n\n<p>MTRR\uff5cHomocystinuria-Megaloblastic Anemia, cblE Type<\/p>\n\n\n\n<p><sup>HMAE; Homocystinuria-Megaloblastic anemia due to defect in cobalamin metabolism, cblE complementation type; Vitamin B12-responsive Homocystinuria, cblE <\/sup><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u6982\u8981 | Overview<\/h2>\n\n\n\n<p>\u30db\u30e2\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u30fb\u5de8\u8d64\u82bd\u7403\u6027\u8ca7\u8840 cblE \u578b\uff08HMAE\uff09\u306f\u3001\u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u3092\u30e1\u30c1\u30aa\u30cb\u30f3\u306b\u5909\u63db\u3059\u308b\u30d3\u30bf\u30df\u30f3B12\uff08\u30b3\u30d0\u30e9\u30df\u30f3\uff09\u4f9d\u5b58\u6027\u306e\u7d4c\u8def\u306b\u7570\u5e38\u304c\u751f\u3058\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u767a\u75c7\u3059\u308b\u3001\u5e38\u67d3\u8272\u4f53\u52a3\u6027\u306e\u5148\u5929\u6027\u4ee3\u8b1d\u7570\u5e38\u75c7\u3067\u3059\u3002\u3053\u306e\u75be\u60a3\u306f\u3001\u7cbe\u795e\u904b\u52d5\u767a\u9054\u306e\u9045\u308c\u3001\u5de8\u8d64\u82bd\u7403\u6027\u8ca7\u8840\u3001\u30db\u30e2\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u3001\u4f4e\u30e1\u30c1\u30aa\u30cb\u30f3\u8840\u75c7\u306a\u3069\u3092\u7279\u5fb4\u3068\u3057\u307e\u3059\u3002\u539f\u56e0\u907a\u4f1d\u5b50\u3067\u3042\u308b MTRR \u907a\u4f1d\u5b50\u306f\u3001\u30e1\u30c1\u30aa\u30cb\u30f3\u5408\u6210\u9175\u7d20\u9084\u5143\u9175\u7d20\uff08Methionine Synthase Reductase: MSR\uff09\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u9175\u7d20\u306f\u30e1\u30c1\u30aa\u30cb\u30f3\u5408\u6210\u9175\u7d20\uff08Methionine Synthase: MTR\uff09\u306e\u6d3b\u6027\u5316\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7d4c\u8def\u304c\u969c\u5bb3\u3055\u308c\u308b\u3068\u3001\u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u4ee3\u8b1d\u306b\u7570\u5e38\u304c\u751f\u3058\u3001\u69d8\u3005\u306a\u81e8\u5e8a\u75c7\u72b6\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u75ab\u5b66 | Epidemiology<\/h2>\n\n\n\n<p>HMAE \u306f\u975e\u5e38\u306b\u7a00\u306a\u4ee3\u8b1d\u7570\u5e38\u75c7\u3067\u3042\u308a\u3001\u6b63\u78ba\u306a\u6709\u75c5\u7387\u306e\u30c7\u30fc\u30bf\u306f\u4e0d\u660e\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u30b3\u30d0\u30e9\u30df\u30f3\u4ee3\u8b1d\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u6027\u75be\u60a3\u306f\u3001\u8840\u7e01\u5a5a\u304c\u591a\u3044\u96c6\u56e3\u306b\u304a\u3044\u3066\u6bd4\u8f03\u7684\u9ad8\u983b\u5ea6\u306b\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u306e\u907a\u4f1d\u5b50\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u6280\u8853\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u3053\u308c\u3089\u306e\u75be\u60a3\u306e\u8a3a\u65ad\u7387\u304c\u5411\u4e0a\u3057\u3001\u5831\u544a\u4f8b\u304c\u5897\u52a0\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u75c5\u56e0 | Etiology<\/h2>\n\n\n\n<p>HMAE \u306f\u30015\u756a\u67d3\u8272\u4f53\u77ed\u8155\uff085p15.31\uff09\u306b\u4f4d\u7f6e\u3059\u308b MTRR \u907a\u4f1d\u5b50\u306e\u30db\u30e2\u63a5\u5408\u6027\u307e\u305f\u306f\u8907\u5408\u30d8\u30c6\u30ed\u63a5\u5408\u6027\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002MTRR \u907a\u4f1d\u5b50\u306f\u3001\u30e1\u30c1\u30aa\u30cb\u30f3\u5408\u6210\u9175\u7d20\u9084\u5143\u9175\u7d20\uff08MSR\uff09\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u9175\u7d20\u306f\u30e1\u30c1\u30aa\u30cb\u30f3\u5408\u6210\u9175\u7d20\uff08MTR\uff09\u306e\u6d3b\u6027\u3092\u7dad\u6301\u3059\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002MTR \u306f\u3001\u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u3092\u30e1\u30c1\u30aa\u30cb\u30f3\u3078\u5909\u63db\u3059\u308b\u969b\u306b\u3001\u88dc\u56e0\u5b50\u3068\u3057\u3066\u30e1\u30c1\u30eb\u30b3\u30d0\u30e9\u30df\u30f3\uff08\u30d3\u30bf\u30df\u30f3B12\u306e\u4e00\u7a2e\uff09\u3092\u5229\u7528\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u9175\u7d20\u306e\u89e6\u5a92\u30b5\u30a4\u30af\u30eb\u306e\u904e\u7a0b\u3067\u3001\u30b3\u30d0\u30e9\u30df\u30f3\u88dc\u56e0\u5b50\u304c\u9178\u5316\u3057\u3001\u4e0d\u6d3b\u6027\u5316\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u4e0d\u6d3b\u6027\u5316\u3055\u308c\u305f\u72b6\u614b\uff08\u30b3\u30d0(II)\u30a2\u30e9\u30df\u30f3\uff09\u3092\u9084\u5143\u3057\u3066\u3001\u518d\u3073\u6d3b\u6027\u5316\u3059\u308b\u5f79\u5272\u3092\u679c\u305f\u3059\u306e\u304c MSR \u3067\u3059\u3002MTRR \u907a\u4f1d\u5b50\u306e\u7570\u5e38\u306b\u3088\u308a MSR \u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001MTR \u306e\u6d3b\u6027\u304c\u7dad\u6301\u3067\u304d\u305a\u3001\u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u306e\u30ea\u30b5\u30a4\u30af\u30eb\u304c\u963b\u5bb3\u3055\u308c\u3001\u4ee3\u8b1d\u7570\u5e38\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<!-- CTA Button -->\n\n<figure class=\"cta-btn\">\n<div class=\"cta-img\">\n<img decoding=\"async\" src=\"\/nipt\/wp-content\/uploads\/2023\/03\/button_pc.png\" alt=\"\u539f\u56e0\">\n<\/div>\n<div class=\"button-1\">\n<img decoding=\"async\" src=\"\/nipt\/wp-content\/uploads\/2023\/03\/cta-btn-orng-2.png\">\n<img decoding=\"async\" class=\"button-2\" src=\"\/nipt\/wp-content\/uploads\/2023\/03\/cta-btn-down.png\" alt=\"blue-btn\">\n<\/div>\n<\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">\u75c7\u72b6 | Symptoms<\/h2>\n\n\n\n<p>HMAE \u306e\u81e8\u5e8a\u75c7\u72b6\u306f\u500b\u3005\u306e\u60a3\u8005\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u304c\u3001\u4e3b\u306b\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u75c7\u72b6\u304c\u307f\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7cbe\u795e\u904b\u52d5\u767a\u9054\u306e\u9045\u308c<\/li>\n\n\n\n<li>\u5de8\u8d64\u82bd\u7403\u6027\u8ca7\u8840\uff08\u8d64\u8840\u7403\u306e\u7570\u5e38\u306a\u5897\u5927\uff09<\/li>\n\n\n\n<li>\u7b4b\u7dca\u5f35\u4f4e\u4e0b\uff08\u4f4e\u7dca\u5f35\uff09<\/li>\n\n\n\n<li>\u9ad8\u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u8840\u75c7<\/li>\n\n\n\n<li>\u30db\u30e2\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\uff08\u5c3f\u4e2d\u306b\u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u304c\u6392\u6cc4\u3055\u308c\u308b\uff09<\/li>\n\n\n\n<li>\u4f4e\u30e1\u30c1\u30aa\u30cb\u30f3\u8840\u75c7\uff08\u8840\u4e2d\u30e1\u30c1\u30aa\u30cb\u30f3\u6fc3\u5ea6\u306e\u4f4e\u4e0b\uff09<\/li>\n\n\n\n<li>\u3051\u3044\u308c\u3093\u767a\u4f5c<\/li>\n\n\n\n<li>\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u3084\u767a\u9054\u9045\u6ede<\/li>\n<\/ul>\n\n\n\n<p>\u91cd\u75c7\u4f8b\u3067\u306f\u3001\u795e\u7d4c\u6a5f\u80fd\u306e\u9032\u884c\u6027\u306e\u60aa\u5316\u3084\u3001\u30e1\u30c1\u30eb\u5316\u969c\u5bb3\u306b\u3088\u308b\u5168\u8eab\u7684\u306a\u554f\u984c\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u691c\u67fb\u30fb\u8a3a\u65ad | Tests &amp; Diagnosis<\/h2>\n\n\n\n<p>HMAE \u306e\u8a3a\u65ad\u306f\u3001\u81e8\u5e8a\u75c7\u72b6\u3001\u8840\u6db2\u691c\u67fb\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u57fa\u3065\u3044\u3066\u884c\u308f\u308c\u307e\u3059\u3002\u4e3b\u306a\u8a3a\u65ad\u65b9\u6cd5\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8840\u6f3f\u30a2\u30df\u30ce\u9178\u5206\u6790<\/strong>: \u9ad8\u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u8840\u75c7\u304a\u3088\u3073\u4f4e\u30e1\u30c1\u30aa\u30cb\u30f3\u8840\u75c7\u3092\u691c\u51fa\u3002<\/li>\n\n\n\n<li><strong>\u8840\u6db2\u4e00\u822c\u691c\u67fb\uff08CBC\uff09<\/strong>: \u5de8\u8d64\u82bd\u7403\u6027\u8ca7\u8840\u306e\u6709\u7121\u3092\u78ba\u8a8d\u3002<\/li>\n\n\n\n<li><strong>\u4ee3\u8b1d\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0<\/strong>: \u30e1\u30c1\u30eb\u30de\u30ed\u30f3\u9178\u5c3f\u75c7\u3092\u4f34\u308f\u306a\u3044\u30db\u30e2\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u3092\u691c\u51fa\u3002<\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u5b50\u691c\u67fb<\/strong>: MTRR \u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u7279\u5b9a\u3002<\/li>\n\n\n\n<li><strong>\u7dda\u7dad\u82bd\u7d30\u80de\u691c\u67fb<\/strong>: \u30e1\u30c1\u30eb\u30c6\u30c8\u30e9\u30d2\u30c9\u30ed\u8449\u9178\u306e\u30e1\u30c1\u30aa\u30cb\u30f3\u3078\u306e\u53d6\u308a\u8fbc\u307f\u80fd\u3092\u8a55\u4fa1\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u6cbb\u7642\u6cd5\u3068\u7ba1\u7406 | Treatment &amp; Management<\/h2>\n\n\n\n<p>HMAE \u306e\u6cbb\u7642\u306f\u3001\u4ee3\u8b1d\u7570\u5e38\u306e\u662f\u6b63\u3068\u75c7\u72b6\u306e\u9032\u884c\u6291\u5236\u3092\u76ee\u7684\u3068\u3057\u307e\u3059\u3002\u4e3b\u306a\u6cbb\u7642\u6cd5\u306b\u306f\u4ee5\u4e0b\u306e\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30b3\u30d0\u30e9\u30df\u30f3\uff08\u30d3\u30bf\u30df\u30f3B12\uff09\u88dc\u5145\u7642\u6cd5<\/strong>: \u30d2\u30c9\u30ed\u30ad\u30bd\u30b3\u30d0\u30e9\u30df\u30f3\u306e\u6ce8\u5c04\u306b\u3088\u308a\u30e1\u30c1\u30eb\u5316\u80fd\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u3002<\/li>\n\n\n\n<li><strong>\u8449\u9178\/\u30db\u30ea\u30ca\u9178\u88dc\u5145<\/strong>: \u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u306e\u518d\u30e1\u30c1\u30eb\u5316\u3092\u652f\u63f4\u3002<\/li>\n\n\n\n<li><strong>\u30d9\u30bf\u30a4\u30f3\u7642\u6cd5<\/strong>: \u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u306e\u30e1\u30c1\u30aa\u30cb\u30f3\u3078\u306e\u4ee3\u66ff\u7684\u306a\u518d\u30e1\u30c1\u30eb\u5316\u3092\u4fc3\u9032\u3002<\/li>\n\n\n\n<li><strong>\u98df\u4e8b\u7ba1\u7406<\/strong>: \u91cd\u75c7\u4f8b\u3067\u306f\u3001\u30e1\u30c1\u30aa\u30cb\u30f3\u6442\u53d6\u306e\u5236\u9650\u304c\u63a8\u5968\u3055\u308c\u308b\u5834\u5408\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u75c7\u72b6\u5225\u6cbb\u7642<\/strong>: \u767a\u9054\u9045\u6ede\u306b\u5bfe\u3059\u308b\u7406\u5b66\u7642\u6cd5\u3084\u8a00\u8a9e\u7642\u6cd5\u306e\u5c0e\u5165\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u65e9\u671f\u8a3a\u65ad\u3068\u9069\u5207\u306a\u6cbb\u7642\u4ecb\u5165\u306b\u3088\u308a\u3001\u81e8\u5e8a\u7d4c\u904e\u306e\u6539\u5584\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e88\u5f8c | Prognosis<\/h2>\n\n\n\n<p>HMAE \u306e\u4e88\u5f8c\u306f\u3001\u9175\u7d20\u6d3b\u6027\u306e\u4f4e\u4e0b\u5ea6\u5408\u3044\u3084\u6cbb\u7642\u958b\u59cb\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u306b\u3088\u308a\u7570\u306a\u308a\u307e\u3059\u3002\u65e9\u671f\u306b\u8a3a\u65ad\u3055\u308c\u3001\u9069\u5207\u306a\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u8005\u3067\u306f\u3001\u4ee3\u8b1d\u7570\u5e38\u306e\u5b89\u5b9a\u5316\u3068\u767a\u9054\u306e\u6539\u5584\u304c\u898b\u8fbc\u3081\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u8a3a\u65ad\u304c\u9045\u308c\u305f\u308a\u6cbb\u7642\u304c\u4e0d\u5341\u5206\u3067\u3042\u3063\u305f\u5834\u5408\u306b\u306f\u3001\u9032\u884c\u6027\u306e\u795e\u7d4c\u969c\u5bb3\u304c\u307f\u3089\u308c\u3001\u751f\u547d\u4e88\u5f8c\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u9577\u671f\u7684\u306a\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u3092\u884c\u3044\u3001\u6cbb\u7642\u52b9\u679c\u3092\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3057\u306a\u304c\u3089\u9069\u5207\u306a\u7ba1\u7406\u3092\u7d99\u7d9a\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<div class=\"wp-block-group references\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.bbadis.2016.10.016\">Bassila, C., Ghemrawi, R., Flayac, J., Froese, D. S., Baumgartner, M. R., Gu\u00e9ant, J. L., &amp; Coelho, D. (2017). Methionine synthase and methionine synthase reductase interact with MMACHC and with MMADHC. <em>Biochimica et biophysica acta. Molecular basis of disease<\/em>, <em>1863<\/em>(1), 103\u2013112. https:\/\/doi.org\/10.1016\/j.bbadis.2016.10.016<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/hmg\/8.11.2009\">Wilson, A., Leclerc, D., Rosenblatt, D. S., &amp; Gravel, R. A. (1999). Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate\/cobalamin metabolism. <em>Human molecular genetics<\/em>, <em>8<\/em>(11), 2009\u20132016. https:\/\/doi.org\/10.1093\/hmg\/8.11.2009<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1073\/pnas.95.6.3059\">Leclerc, D., Wilson, A., Dumas, R., Gafuik, C., Song, D., Watkins, D., Heng, H. H., Rommens, J. M., Scherer, S. W., Rosenblatt, D. S., &amp; Gravel, R. A. (1998). Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria. <em>Proceedings of the National Academy of Sciences of the United States of America<\/em>, <em>95<\/em>(6), 3059\u20133064. https:\/\/doi.org\/10.1073\/pnas.95.6.3059<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1007\/978-3-319-66816-1_1757-1\">Dilanthi, H.W., Indika, NL.R., Jasinge, E. (2023). Homocystinuria-Megaloblastic Anemia. In: Rezaei, N. (eds) Genetic Syndromes. Springer, Cham. https:\/\/doi.org\/10.1007\/978-3-319-66816-1_1757-1<\/a><\/li>\n<\/ul>\n<\/div><\/div>\n","protected":false},"featured_media":0,"menu_order":33,"template":"page_gd.php","class_list":["post-33709","genetic-diseases","type-genetic-diseases","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/33709","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/genetic-diseases"}],"version-history":[{"count":15,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/33709\/revisions"}],"predecessor-version":[{"id":127700,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/33709\/revisions\/127700"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=33709"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}