{"id":60323,"date":"2023-08-25T10:54:48","date_gmt":"2023-08-25T01:54:48","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/?post_type=genetic-diseases&#038;p=60323"},"modified":"2026-05-08T13:37:23","modified_gmt":"2026-05-08T04:37:23","slug":"alport-syndrome","status":"publish","type":"genetic-diseases","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/genetic-diseases2\/alport-syndrome\/","title":{"rendered":"\u30a2\u30eb\u30dd\u30fc\u30c8\u75c7\u5019\u7fa4"},"content":{"rendered":"\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center\"><sup>Alport\u75c7\u5019\u7fa4\uff08COL4A3\u95a2\u9023\uff09\u306f\u3001\u907a\u4f1d\u6027\u306e\u814e\u75be\u60a3\u3067\u3042\u308a\u3001\u8840\u5c3f\u3084\u86cb\u767d\u5c3f\u3001\u9032\u884c\u6027\u306e\u814e\u4e0d\u5168\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001Alport\u75c7\u5019\u7fa4\u306e\u539f\u56e0\u3001\u75c7\u72b6\u3001\u8a3a\u65ad\u65b9\u6cd5\u3001\u6cbb\u7642\u30fb\u7ba1\u7406\u306e\u6700\u65b0\u60c5\u5831\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u3001\u4e88\u5f8c\u3084\u598a\u5a20\u3078\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066\u3082\u6398\u308a\u4e0b\u3052\u307e\u3059\u3002<\/sup><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u907a\u4f1d\u5b50\u30fb\u75be\u60a3\u540d<\/h2>\n\n\n\n<p>COL4A3\uff5cAlport Syndrome (COL4A3-related)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u6982\u8981 | Overview<\/h2>\n\n\n\n<p>Alport\u75c7\u5019\u7fa4\uff08Alport Syndrome, OMIM: 303630, 120070, 120131\uff09\u306f\u3001\u907a\u4f1d\u6027\u306e\u814e\u75be\u60a3\u3067\u3042\u308a\u3001\u8840\u5c3f\u3001\u9032\u884c\u6027\u306e\u814e\u4e0d\u5168\u3001\u611f\u97f3\u6027\u96e3\u8074\u3001\u773c\u7570\u5e38\u3092\u7279\u5fb4\u3068\u3059\u308b\u3002\u907a\u4f1d\u7684\u80cc\u666f\u3068\u3057\u3066\u300185%\u304cX\u9023\u9396\uff08X-linked, XLAS\uff09\u578b\u3067\u3042\u308a\u3001COL4A5\u907a\u4f1d\u5b50\u306e\u75c5\u7684\u30d0\u30ea\u30a2\u30f3\u30c8\u304c\u539f\u56e0\u3068\u306a\u308b\u3002\u6b8b\u308a\u306e15%\u306f\u5e38\u67d3\u8272\u4f53\u52a3\u6027\uff08autosomal recessive, ARAS\uff09\u578b\u3067\u3042\u308a\u3001COL4A3\u307e\u305f\u306fCOL4A4\u907a\u4f1d\u5b50\u306e\u4e21\u5bfe\u7acb\u907a\u4f1d\u5b50\u306b\u75c5\u7684\u30d0\u30ea\u30a2\u30f3\u30c8\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u3067\u767a\u75c7\u3059\u308b\u3002\u307e\u305f\u3001COL4A3\u307e\u305f\u306fCOL4A4\u907a\u4f1d\u5b50\u306e\u5358\u4e00\u75c5\u7684\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6709\u3059\u308b\u500b\u4f53\u306f\u3001\u304b\u3064\u3066\u8584\u57fa\u5e95\u819c\u75c7\uff08thin basement membrane nephropathy, TBMN\uff09\u3068\u547c\u3070\u308c\u3066\u3044\u305f\u304c\u3001\u73fe\u5728\u3067\u306f\u5e38\u67d3\u8272\u4f53\u512a\u6027\uff08autosomal dominant, ADAS\uff09\u578bAlport\u75c7\u5019\u7fa4\u3068\u5206\u985e\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3002\u3053\u308c\u3089\u306e\u500b\u4f53\u306e\u5927\u90e8\u5206\u306f\u8840\u5c3f\u3092\u5448\u3059\u308b\u304c\u3001\u86cb\u767d\u5c3f\u3084\u814e\u6a5f\u80fd\u4f4e\u4e0b\u3001\u611f\u97f3\u6027\u96e3\u8074\u3001\u773c\u7570\u5e38\u306e\u30ea\u30b9\u30af\u306f\u4f4e\u3044\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u75ab\u5b66 | Epidemiology<\/h2>\n\n\n\n<p>Alport\u75c7\u5019\u7fa4\u306f\u3001\u5e38\u67d3\u8272\u4f53\u512a\u6027\u591a\u767a\u6027\u56a2\u80de\u814e\uff08autosomal dominant polycystic kidney disease, ADPKD\uff09\u306b\u6b21\u3044\u3067\u3001\u907a\u4f1d\u6027\u814e\u4e0d\u5168\u306e\u539f\u56e0\u3068\u3057\u30662\u756a\u76ee\u306b\u591a\u3044\u75be\u60a3\u3067\u3042\u308b\u3002\u767a\u75c7\u983b\u5ea6\u306f\u6700\u4f4e\u3067\u30821\/5,000\u3067\u3042\u308a\u3001\u5b9f\u969b\u306b\u306f1\/2,000\u7a0b\u5ea6\u306e\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u308b\u3002\u7279\u306bX\u9023\u9396\u578b\u306eAlport\u75c7\u5019\u7fa4\uff08XLAS\uff09\u3092\u6709\u3059\u308b\u7537\u6027\u3067\u306f\u300190%\u304c40\u6b73\u307e\u3067\u306b\u672b\u671f\u814e\u4e0d\u5168\uff08end-stage kidney failure, ESKF\uff09\u306b\u9032\u884c\u3059\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u4e00\u65b9\u3001\u5973\u6027\u306eXLAS\u4fdd\u56e0\u8005\u3067\u306f\u300160\u6b73\u307e\u3067\u306b\u814e\u4e0d\u5168\u3092\u767a\u75c7\u3059\u308b\u5272\u5408\u304c15\u201330%\u3068\u3055\u308c\u308b\u3002\u5e38\u67d3\u8272\u4f53\u52a3\u6027\u578b\uff08ARAS\uff09\u306e\u60a3\u8005\u306f\u300120\u4ee3\u306e\u3046\u3061\u306b\u814e\u4e0d\u5168\u306b\u9032\u884c\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3002<\/p>\n\n\n\n<p>COL4A3\u307e\u305f\u306fCOL4A4\u306e\u30d8\u30c6\u30ed\u63a5\u5408\u6027\u75c5\u7684\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u500b\u4f53\u306f\u3001\u4eba\u53e3\u306e\u7d041%\u306b\u898b\u3089\u308c\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u3046\u3061\u7d0410%\u304c60\u6b73\u307e\u3067\u306b\u814e\u4e0d\u5168\u3092\u767a\u75c7\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u75c5\u56e0 | Etiology<\/h2>\n\n\n\n<p>Alport\u75c7\u5019\u7fa4\u306f\u3001COL4A3\u3001COL4A4\u3001COL4A5\u907a\u4f1d\u5b50\u306e\u75c5\u7684\u30d0\u30ea\u30a2\u30f3\u30c8\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3002\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306f\u3001\u814e\u7cf8\u7403\u4f53\u57fa\u5e95\u819c\uff08glomerular basement membrane, GBM\uff09\u3092\u69cb\u6210\u3059\u308b\u30b3\u30e9\u30fc\u30b2\u30f3IV \u03b13\u03b14\u03b15\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u5408\u6210\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306b\u75c5\u7684\u5909\u7570\u304c\u751f\u3058\u308b\u3068\u3001GBM\u306e\u69cb\u9020\u7570\u5e38\u304c\u767a\u751f\u3057\u3001\u8840\u5c3f\u3084\u9032\u884c\u6027\u306e\u7cf8\u7403\u4f53\u786c\u5316\u3001\u814e\u4e0d\u5168\u3078\u3068\u9032\u884c\u3059\u308b\u3002<\/p>\n\n\n\n<p>\u75c5\u7684\u30d0\u30ea\u30a2\u30f3\u30c8\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u91cd\u5ea6\u5909\u7570\uff08severe variants\uff09<\/strong>\uff1a\u5927\u898f\u6a21\u6b20\u5931\u3001\u30ca\u30f3\u30bb\u30f3\u30b9\u5909\u7570\u3001\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u5909\u7570\u306a\u3069\u3002\u3053\u308c\u3089\u306f\u65e9\u671f\u306e\u814e\u4e0d\u5168\u3084\u611f\u97f3\u6027\u96e3\u8074\u3001\u773c\u7570\u5e38\u3092\u4f34\u3046\u50be\u5411\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u8efd\u5ea6\u5909\u7570\uff08mild variants\uff09<\/strong>\uff1a\u30df\u30b9\u30bb\u30f3\u30b9\u5909\u7570\u3001\u7279\u306bGly\u7f6e\u63db\u5909\u7570\u3002\u3053\u308c\u3089\u306f\u767a\u75c7\u5e74\u9f62\u304c\u9045\u304f\u3001\u75c7\u72b6\u304c\u8efd\u5ea6\u306a\u50be\u5411\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u75c7\u72b6 | Symptoms<\/h2>\n\n\n\n<p>Alport\u75c7\u5019\u7fa4\u306e\u4e3b\u306a\u75c7\u72b6\u306b\u306f\u4ee5\u4e0b\u304c\u542b\u307e\u308c\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u814e\u75c7\u72b6<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u6301\u7d9a\u7684\u306a\u8840\u5c3f\uff08\u9855\u5fae\u93e1\u7684\u307e\u305f\u306f\u8089\u773c\u7684\uff09<\/li>\n\n\n\n<li>\u86cb\u767d\u5c3f\uff08\u9032\u884c\u306b\u4f34\u3044\u5897\u52a0\uff09<\/li>\n\n\n\n<li>\u9032\u884c\u6027\u306e\u814e\u4e0d\u5168\uff08XLAS\u304a\u3088\u3073ARAS\u3067\u306f\u7279\u306b\u65e9\u671f\uff09<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u8074\u899a\u75c7\u72b6<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u611f\u97f3\u6027\u96e3\u8074\uff08\u7279\u306b\u9ad8\u97f3\u57df\uff09<\/li>\n\n\n\n<li>XLAS\u304a\u3088\u3073ARAS\u3067\u4e00\u822c\u7684\u3001ADAS\u3067\u306f\u307e\u308c<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u773c\u75c7\u72b6<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30ec\u30f3\u30c1\u30b3\u30cc\u30b9\uff08\u524d\u6c34\u6676\u4f53\u5186\u9310\uff09<\/li>\n\n\n\n<li>\u30d5\u30ec\u30c3\u30af\u7db2\u819c\u75c7<\/li>\n\n\n\n<li>\u7db2\u819c\u8272\u7d20\u5909\u6027\uff08\u91cd\u75c7\u4f8b\uff09<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u691c\u67fb\u30fb\u8a3a\u65ad | Tests &amp; Diagnosis<\/h2>\n\n\n\n<p>Alport\u75c7\u5019\u7fa4\u306e\u8a3a\u65ad\u306f\u4ee5\u4e0b\u306e\u691c\u67fb\u306b\u3088\u3063\u3066\u884c\u308f\u308c\u308b\u3002<\/p>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li><strong>\u5c3f\u691c\u67fb<\/strong>\uff1a\u8840\u5c3f\u306e\u6301\u7d9a\u7684\u5b58\u5728\u3001\u86cb\u767d\u5c3f\u306e\u6709\u7121<\/li>\n\n\n\n<li><strong>\u814e\u751f\u691c<\/strong>\uff1aGBM\u306e\u83f2\u8584\u5316\u3001\u5c64\u677f\u72b6\u5909\u5316\u3001\u30b3\u30e9\u30fc\u30b2\u30f3IV \u03b15\u9396\u306e\u514d\u75ab\u67d3\u8272\u6b20\u640d<\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u5b50\u691c\u67fb<\/strong>\uff1aCOL4A3\u3001COL4A4\u3001COL4A5\u907a\u4f1d\u5b50\u306e\u75c5\u7684\u30d0\u30ea\u30a2\u30f3\u30c8\u306e\u540c\u5b9a<\/li>\n\n\n\n<li><strong>\u8074\u529b\u691c\u67fb<\/strong>\uff1a\u9ad8\u97f3\u57df\u306e\u611f\u97f3\u6027\u96e3\u8074\u306e\u6709\u7121<\/li>\n\n\n\n<li><strong>\u773c\u79d1\u691c\u67fb<\/strong>\uff1a\u30ec\u30f3\u30c1\u30b3\u30cc\u30b9\u3001\u30d5\u30ec\u30c3\u30af\u7db2\u819c\u75c7\u306e\u6709\u7121<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\">\u6cbb\u7642\u6cd5\u3068\u7ba1\u7406 | Treatment &amp; Management<\/h2>\n\n\n\n<p>Alport\u75c7\u5019\u7fa4\u306e\u6cbb\u7642\u306e\u4e2d\u5fc3\u306f\u3001\u814e\u6a5f\u80fd\u4f4e\u4e0b\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u964d\u5727\u7642\u6cd5<\/strong>\uff1a\u30ec\u30cb\u30f3\u30fb\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u7cfb\u963b\u5bb3\u85ac\uff08RASi\uff09\u306e\u4f7f\u7528\uff08ACE\u963b\u5bb3\u85ac\u3001ARB\uff09<\/li>\n\n\n\n<li><strong>\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584<\/strong>\uff1a\u5869\u5206\u5236\u9650\u3001\u8840\u5727\u7ba1\u7406\u3001\u9069\u5ea6\u306a\u904b\u52d5<\/li>\n\n\n\n<li><strong>\u5b9a\u671f\u7684\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0<\/strong>\uff1a\u5c3f\u691c\u67fb\u3001\u8840\u5727\u6e2c\u5b9a\u3001\u814e\u6a5f\u80fd\u8a55\u4fa1<\/li>\n\n\n\n<li><strong>\u814e\u4e0d\u5168\u306e\u9032\u884c\u6642\u306e\u5bfe\u5fdc<\/strong>\uff1a\u900f\u6790\u307e\u305f\u306f\u814e\u79fb\u690d<\/li>\n<\/ul>\n\n\n\n<p>\u307e\u305f\u3001XLAS\u304a\u3088\u3073ARAS\u306e\u60a3\u8005\u3067\u306f\u3001\u8074\u899a\u304a\u3088\u3073\u773c\u79d1\u7684\u7ba1\u7406\u304c\u5fc5\u8981\u3067\u3042\u308a\u3001\u88dc\u8074\u5668\u306e\u88c5\u7528\u3084\u767d\u5185\u969c\u624b\u8853\u306a\u3069\u306e\u9069\u5fdc\u3092\u691c\u8a0e\u3059\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e88\u5f8c | Prognosis<\/h2>\n\n\n\n<p>Alport\u75c7\u5019\u7fa4\u306e\u4e88\u5f8c\u306f\u907a\u4f1d\u578b\u304a\u3088\u3073\u75c5\u7684\u30d0\u30ea\u30a2\u30f3\u30c8\u306e\u7a2e\u985e\u306b\u4f9d\u5b58\u3059\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>XLAS\uff08\u7537\u6027\uff09<\/strong>\uff1a90%\u304c40\u6b73\u307e\u3067\u306b\u814e\u4e0d\u5168\u306b\u9032\u884c<\/li>\n\n\n\n<li><strong>XLAS\uff08\u5973\u6027\uff09<\/strong>\uff1a15\u201330%\u304c60\u6b73\u307e\u3067\u306b\u814e\u4e0d\u5168\u306b\u9032\u884c<\/li>\n\n\n\n<li><strong>ARAS<\/strong>\uff1a20\u4ee3\u3067\u814e\u4e0d\u5168\u306b\u9032\u884c\u3059\u308b\u3053\u3068\u304c\u591a\u3044<\/li>\n\n\n\n<li><strong>ADAS<\/strong>\uff1a\u814e\u4e0d\u5168\u306e\u30ea\u30b9\u30af\u306f\u4f4e\u3044\u304c\u3001\u52a0\u9f62\u3068\u3068\u3082\u306b\u86cb\u767d\u5c3f\u3084\u814e\u6a5f\u80fd\u4f4e\u4e0b\u306e\u53ef\u80fd\u6027\u3042\u308a<\/li>\n<\/ul>\n\n\n\n<p>\u598a\u5a20\u306b\u95a2\u3057\u3066\u306f\u3001XLAS\u304a\u3088\u3073ADAS\u306e\u5973\u6027\u3067\u306f\u5927\u90e8\u5206\u304c\u826f\u597d\u306a\u7d4c\u904e\u3092\u305f\u3069\u308b\u304c\u3001ARAS\u3067\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/premature-birth\/\">\u65e9\u7523<\/a>\u3084\u4f4e\u51fa\u751f\u4f53\u91cd\u5150\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3002\u3053\u308c\u3089\u306e\u30ea\u30b9\u30af\u306b\u57fa\u3065\u3044\u305f\u500b\u5225\u5316\u533b\u7642\u304c\u6c42\u3081\u3089\u308c\u308b\u3002<\/p>\n\n\n\n<p>\u672c\u75c7\u306e\u65e9\u671f\u8a3a\u65ad\u3068\u9069\u5207\u306a\u7ba1\u7406\u306b\u3088\u308a\u3001\u814e\u4e0d\u5168\u3078\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308a\u3001\u60a3\u8005\u306eQOL\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e\uff5cReferences<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1053\/j.ajkd.2021.04.017\">Savige, J., &amp; Harraka, P. (2021). Pathogenic variants in the genes affected in alport syndrome (Col4a3\u2013col4a5) and their association with other kidney conditions: A review. <em>American Journal of Kidney Diseases<\/em>, <em>78<\/em>(6), 857\u2013864. https:\/\/doi.org\/10.1053\/j.ajkd.2021.04.017<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3389\/fmed.2022.865034\">Savige, J., Huang, M., Croos Dabrera, M. S., Shukla, K., &amp; Gibson, J. (2022). Genotype-phenotype correlations for pathogenic col4a3\u2013col4a5 variants in x-linked, autosomal recessive, and autosomal dominant alport syndrome. <em>Frontiers in Medicine<\/em>, <em>9<\/em>, 865034. https:\/\/doi.org\/10.3389\/fmed.2022.865034<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.ekir.2022.06.001\">Savige, J. (2022). Heterozygous pathogenic col4a3 and col4a4 variants (Autosomal dominant alport syndrome) are common, and not typically associated with end-stage kidney failure, hearing loss, or ocular abnormalities. <em>Kidney International Reports<\/em>, <em>7<\/em>(9), 1933\u20131938. https:\/\/doi.org\/10.1016\/j.ekir.2022.06.001<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1159\/000533915\">Yavas, C., Ozgenturk, N. O., Dogan, M., Gezdirici, A., Keskin, E., \u0130li, E. G., Dogan, T., Celebi, E., Bender, O., &amp; Un, C. (2024). A Deeper Insight into <em>COL4A3<\/em>, <em>COL4A4<\/em>, and <em>COL4A5<\/em> Variants and Genotype-Phenotype Correlation of a Turkish Cohort with Alport Syndrome. <em>Molecular syndromology<\/em>, <em>15<\/em>(1), 1\u201313. https:\/\/doi.org\/10.1159\/000533915<\/a><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9\uff5cKeywords<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup><sup>Alport\u75c7\u5019\u7fa4, COL4A3, COL4A4, COL4A5, \u907a\u4f1d\u6027\u814e\u75be\u60a3, \u8840\u5c3f, \u86cb\u767d\u5c3f, \u814e\u4e0d\u5168, \u611f\u97f3\u6027\u96e3\u8074, \u57fa\u5e95\u819c\u7570\u5e38, \u7cf8\u7403\u4f53\u57fa\u5e95\u819c, \u814e\u81d3\u75c5<\/sup><\/sup><\/p>\n","protected":false},"featured_media":0,"menu_order":0,"template":"page_gd.php","class_list":["post-60323","genetic-diseases","type-genetic-diseases","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/60323","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/genetic-diseases"}],"version-history":[{"count":6,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/60323\/revisions"}],"predecessor-version":[{"id":128109,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/60323\/revisions\/128109"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=60323"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}