{"id":60379,"date":"2023-08-25T14:34:59","date_gmt":"2023-08-25T05:34:59","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/?post_type=genetic-diseases&#038;p=60379"},"modified":"2026-05-08T13:42:49","modified_gmt":"2026-05-08T04:42:49","slug":"prop1-related-combined-pituitary-hormone-deficiency","status":"publish","type":"genetic-diseases","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/genetic-diseases2\/prop1-related-combined-pituitary-hormone-deficiency\/","title":{"rendered":"PROP1\u95a2\u9023\u8907\u5408\u4e0b\u5782\u4f53\u30db\u30eb\u30e2\u30f3\u6b20\u640d\u75c7"},"content":{"rendered":"\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center\"><sup>PROP1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b<strong>\u8907\u5408\u578b\u4e0b\u5782\u4f53\u30db\u30eb\u30e2\u30f3\u6b20\u4e4f\u75c72\uff08CPHD2\uff09<\/strong>\u306f\u3001\u6210\u9577\u30db\u30eb\u30e2\u30f3\uff08GH\uff09\u3084\u7532\u72b6\u817a\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\uff08TSH\uff09\u3001\u6027\u817a\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\uff08LH\u30fbFSH\uff09\u306a\u3069\u306e\u5206\u6ccc\u4f4e\u4e0b\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001CPHD2\u306e\u539f\u56e0\u3001\u75c7\u72b6\u3001\u8a3a\u65ad\u65b9\u6cd5\u3001\u6cbb\u7642\u6cd5\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u3001\u65e9\u671f\u767a\u898b\u3068\u9069\u5207\u306a\u7ba1\u7406\u306e\u91cd\u8981\u6027\u3092\u8aac\u660e\u3057\u307e\u3059\u3002<\/sup><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u907a\u4f1d\u5b50\u30fb\u75be\u60a3\u540d<\/h2>\n\n\n\n<p>PROP1\uff5cCombined Pituitary Hormone Deficiency 2<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u6982\u8981 | Overview<\/h2>\n\n\n\n<p>\u8907\u5408\u578b\u4e0b\u5782\u4f53\u30db\u30eb\u30e2\u30f3\u6b20\u4e4f\u75c72\uff08Combined Pituitary Hormone Deficiency 2, CPHD2\uff09\u306f\u3001\u4e0b\u5782\u4f53\u524d\u8449\u30db\u30eb\u30e2\u30f3\u306e\u3046\u3061\u6210\u9577\u30db\u30eb\u30e2\u30f3\uff08GH\uff09\u30681\u3064\u4ee5\u4e0a\u306e\u30db\u30eb\u30e2\u30f3\u306e\u5206\u6ccc\u304c\u969c\u5bb3\u3055\u308c\u308b\u75be\u60a3\u3067\u3042\u308b\u3002\u672c\u75be\u60a3\u306f\u3001PROP1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3053\u3068\u304c\u6700\u3082\u591a\u304f\u3001\u4e0b\u5782\u4f53\u306e\u767a\u751f\u3068\u6a5f\u80fd\u306b\u95a2\u308f\u308b\u8ee2\u5199\u56e0\u5b50\u306e\u7570\u5e38\u304c\u75c5\u614b\u306e\u4e2d\u5fc3\u306b\u3042\u308b\u3002GH\u3001\u7532\u72b6\u817a\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\uff08TSH\uff09\u3001\u526f\u814e\u76ae\u8cea\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\uff08ACTH\uff09\u3001\u30d7\u30ed\u30e9\u30af\u30c1\u30f3\uff08PRL\uff09\u3001\u304a\u3088\u3073\u6027\u817a\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\uff08LH, FSH\uff09\u306e\u5206\u6ccc\u4f4e\u4e0b\u3092\u7279\u5fb4\u3068\u3059\u308b\u3002\u5c0f\u5150\u671f\u306b\u6210\u9577\u969c\u5bb3\u3084\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u3001\u601d\u6625\u671f\u9045\u5ef6\u3001\u3055\u3089\u306b\u306f\u4e0d\u598a\u75c7\u306a\u3069\u304c\u8a8d\u3081\u3089\u308c\u3001\u6210\u4eba\u671f\u306b\u306f\u526f\u814e\u4e0d\u5168\u304c\u9032\u884c\u3059\u308b\u3053\u3068\u304c\u3042\u308b\u3002\u672c\u75be\u60a3\u306f\u3001\u9069\u5207\u306a\u30db\u30eb\u30e2\u30f3\u88dc\u5145\u7642\u6cd5\u306b\u3088\u3063\u3066\u7ba1\u7406\u53ef\u80fd\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u75ab\u5b66 | Epidemiology<\/h2>\n\n\n\n<p>CPHD\u306e\u6709\u75c5\u7387\u306f\u5168\u4e16\u754c\u3067\u7d041\/8000\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u308b\u3002\u672c\u75be\u60a3\u306e\u5927\u90e8\u5206\u306f\u975e\u907a\u4f1d\u6027\u3067\u3042\u308a\u3001\u8133\u5916\u79d1\u624b\u8853\u3001\u611f\u67d3\u75c7\u3001\u653e\u5c04\u7dda\u6cbb\u7642\u3001\u816b\u760d\u3001\u91cd\u91d1\u5c5e\u4e2d\u6bd2\u3001\u5916\u50b7\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306a\u3069\u304c\u539f\u56e0\u3068\u306a\u308b\u3002\u4e00\u65b9\u3067\u3001PROP1\u3092\u542b\u3080\u8907\u6570\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u5148\u5929\u7684\u306aCPHD\u306e\u539f\u56e0\u3068\u306a\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u308b\u75c7\u4f8b\u306f\u5168\u4f53\u306e5\uff5e30%\u306b\u76f8\u5f53\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002PROP1\u907a\u4f1d\u5b50\u5909\u7570\u306f\u3001\u7279\u306b\u5bb6\u65cf\u6027CPHD\u306b\u304a\u3044\u306630\uff5e50%\u306e\u75c7\u4f8b\u306b\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u5730\u7406\u7684\u30fb\u6c11\u65cf\u7684\u96c6\u56e3\u306b\u304a\u3044\u3066\u907a\u4f1d\u7684\u30dc\u30c8\u30eb\u30cd\u30c3\u30af\u3084\u5275\u59cb\u8005\u52b9\u679c\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u75c5\u56e0 | Etiology<\/h2>\n\n\n\n<p>PROP1\u907a\u4f1d\u5b50\u306f\u3001\u4e0b\u5782\u4f53\u306e\u767a\u751f\u3068\u6a5f\u80fd\u7dad\u6301\u306b\u95a2\u4e0e\u3059\u308b\u8ee2\u5199\u56e0\u5b50\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u30015q35.3\u306b\u4f4d\u7f6e\u3059\u308b\u3002PROP1\u306f\u3001POU1F1\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3057\u3001\u6210\u9577\u30db\u30eb\u30e2\u30f3\u7523\u751f\u7d30\u80de\uff08GH\u7523\u751f\u7d30\u80de\uff09\u3001\u7532\u72b6\u817a\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\u7523\u751f\u7d30\u80de\uff08TSH\u7523\u751f\u7d30\u80de\uff09\u3001\u304a\u3088\u3073\u30d7\u30ed\u30e9\u30af\u30c1\u30f3\u7523\u751f\u7d30\u80de\uff08PRL\u7523\u751f\u7d30\u80de\uff09\u306e\u5206\u5316\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3002PROP1\u306e\u6a5f\u80fd\u55aa\u5931\u578b\u5909\u7570\u306f\u3001\u3053\u308c\u3089\u306e\u7d30\u80de\u306e\u767a\u9054\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u4e0b\u5782\u4f53\u30db\u30eb\u30e2\u30f3\u306e\u5206\u6ccc\u4f4e\u4e0b\u3092\u3082\u305f\u3089\u3059\u3002\u4ee3\u8868\u7684\u306a\u5909\u7570\u3068\u3057\u3066c.301_302delAG\u30d5\u30ec\u30fc\u30e0\u30b7\u30d5\u30c8\u5909\u7570\u304c\u3042\u308a\u3001\u3053\u306e\u5909\u7570\u306b\u3088\u308aDNA\u7d50\u5408\u80fd\u3092\u5931\u3044\u8ee2\u5199\u6d3b\u6027\u304c\u4f4e\u4e0b\u3059\u308b\u3002\u3053\u308c\u3089\u306e\u5909\u7570\u306f\u5bb6\u65cf\u6027\u304a\u3088\u3073\u5b64\u767a\u6027\u306e\u4e21\u65b9\u306eCPHD\u75c7\u4f8b\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u75c7\u72b6 | Symptoms<\/h2>\n\n\n\n<p>PROP1\u95a2\u9023CPHD\u306e\u4e3b\u306a\u75c7\u72b6\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5c0f\u5150\u671f<\/strong>\uff1a\u6210\u9577\u969c\u5bb3\u3001\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\uff08\u8efd\u5ea6\uff09\u3001\u4f4e\u8eab\u9577<\/li>\n\n\n\n<li><strong>\u601d\u6625\u671f<\/strong>\uff1a\u6027\u817a\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\u306e\u5206\u6ccc\u4f4e\u4e0b\u306b\u3088\u308b\u601d\u6625\u671f\u9045\u5ef6\u3001\u672a\u767a\u9054\u306a\u7b2c\u4e8c\u6b21\u6027\u5fb4\u3001\u4e0d\u598a\u75c7\uff08\u6cbb\u7642\u306a\u3057\u3067\u306f\u751f\u6b96\u80fd\u529b\u306a\u3057\uff09<\/li>\n\n\n\n<li><strong>\u6210\u4eba\u671f<\/strong>\uff1a\u526f\u814e\u76ae\u8cea\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\uff08ACTH\uff09\u6b20\u4e4f\u306b\u4f34\u3046\u526f\u814e\u4e0d\u5168\uff08\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u4f4e\u4e0b\u3001\u611f\u67d3\u75c7\u30ea\u30b9\u30af\u5897\u5927\uff09<\/li>\n\n\n\n<li><strong>\u7a00\u306a\u75c7\u72b6<\/strong>\uff1a\u77ed\u9838\u3001\u8996\u795e\u7d4c\u4f4e\u5f62\u6210\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/why-premium-plan\/\">\u77e5\u7684\u969c\u5bb3<\/a>\uff08\u307e\u308c\uff09<\/li>\n<\/ul>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u591a\u304f\u306e\u60a3\u8005\u306f\u51fa\u751f\u6642\u306e\u8eab\u4f53\u767a\u80b2\u306f\u6b63\u5e38\u3067\u3042\u308a\u3001\u65b0\u751f\u5150\u671f\u306e\u4f4e\u8840\u7cd6\u3084\u9ec4\u75b8\u306f\u5c11\u306a\u3044\u304c\u3001\u5e7c\u5150\u671f\u4ee5\u964d\u306b\u6210\u9577\u9045\u5ef6\u304c\u9855\u5728\u5316\u3059\u308b\u3002TSH\u6b20\u4e4f\u75c7\u306fGH\u6b20\u4e4f\u3068\u540c\u6642\u307e\u305f\u306f\u305d\u308c\u4ee5\u964d\u306b\u767a\u75c7\u3057\u3001\u601d\u6625\u671f\u306eLH\u30fbFSH\u5206\u6ccc\u969c\u5bb3\u306b\u3088\u308a\u4e8c\u6b21\u6027\u5fb4\u306e\u9045\u308c\u304c\u8a8d\u3081\u3089\u308c\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u691c\u67fb\u30fb\u8a3a\u65ad | Tests &amp; Diagnosis<\/h2>\n\n\n\n<p>CPHD\u306e\u8a3a\u65ad\u306f\u81e8\u5e8a\u7684\u6240\u898b\u3068\u30db\u30eb\u30e2\u30f3\u691c\u67fb\u306b\u57fa\u3065\u3044\u3066\u884c\u308f\u308c\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8840\u6db2\u691c\u67fb<\/strong>\uff1aGH\u3001TSH\u3001ACTH\u3001PRL\u3001LH\u3001FSH\u306e\u4f4e\u4e0b<\/li>\n\n\n\n<li><strong>\u6210\u9577\u30db\u30eb\u30e2\u30f3\u523a\u6fc0\u8a66\u9a13<\/strong>\uff1a\u6210\u9577\u30db\u30eb\u30e2\u30f3\u5206\u6ccc\u306e\u4f4e\u4e0b<\/li>\n\n\n\n<li><strong>\u7532\u72b6\u817a\u6a5f\u80fd\u691c\u67fb<\/strong>\uff1a\u904a\u96e2T4\u4f4e\u5024\u3001TSH\u4f4e\u5024<\/li>\n\n\n\n<li><strong>ACTH\u523a\u6fc0\u8a66\u9a13<\/strong>\uff1a\u526f\u814e\u4e0d\u5168\u306e\u8a55\u4fa1<\/li>\n\n\n\n<li><strong>MRI\u691c\u67fb<\/strong>\uff1a\u4e0b\u5782\u4f53\u306e\u4f4e\u5f62\u6210\u3001\u80a5\u5927\u3001\u307e\u305f\u306f\u6b63\u5e38\u50cf<\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u5b50\u691c\u67fb<\/strong>\uff1aPROP1\u907a\u4f1d\u5b50\u306e\u75c5\u7684\u5909\u7570\u3092\u78ba\u8a8d<\/li>\n<\/ul>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>PROP1\u5909\u7570\u3092\u6709\u3059\u308b\u60a3\u8005\u3067\u306f\u3001\u4e0b\u5782\u4f53\u306eMRI\u50cf\u304c\u6b63\u5e38\u307e\u305f\u306f\u4f4e\u5f62\u6210\u3067\u3042\u308b\u3053\u3068\u304c\u591a\u3044\u304c\u3001\u4e00\u90e8\u306e\u75c7\u4f8b\u3067\u306f\u4e00\u904e\u6027\u306e\u4e0b\u5782\u4f53\u80a5\u5927\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u6cbb\u7642\u6cd5\u3068\u7ba1\u7406 | Treatment &amp; Management<\/h2>\n\n\n\n<p>PROP1\u95a2\u9023CPHD\u306e\u6cbb\u7642\u306f\u30db\u30eb\u30e2\u30f3\u88dc\u5145\u7642\u6cd5\u304c\u4e2d\u5fc3\u3068\u306a\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>GH\u88dc\u5145\u7642\u6cd5<\/strong>\uff1a\u6210\u9577\u30db\u30eb\u30e2\u30f3\uff08rhGH\uff09\u3092\u76ae\u4e0b\u6ce8\u5c04<\/li>\n\n\n\n<li><strong>TSH\u6b20\u4e4f\u75c7\u306e\u6cbb\u7642<\/strong>\uff1aL-\u30c1\u30ed\u30ad\u30b7\u30f3\uff08Levothyroxine\uff09\u7d4c\u53e3\u6295\u4e0e<\/li>\n\n\n\n<li><strong>\u6027\u30db\u30eb\u30e2\u30f3\u88dc\u5145\u7642\u6cd5<\/strong>\uff1a\n<ul class=\"wp-block-list\">\n<li>\u7537\u5150\uff1a12\uff5e13\u6b73\u304b\u3089\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u30a8\u30ca\u30f3\u30c6\u30fc\u30c8\u306e\u7b4b\u6ce8<\/li>\n\n\n\n<li>\u5973\u5150\uff1a11\uff5e12\u6b73\u304b\u3089\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\uff08\u5f8c\u306b\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3\u4f75\u7528\uff09<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>ACTH\u6b20\u4e4f\u75c7\u306e\u7ba1\u7406<\/strong>\uff1a\u30d2\u30c9\u30ed\u30b3\u30eb\u30c1\u30be\u30f3\u6295\u4e0e\u3001\u30b9\u30c8\u30ec\u30b9\u6642\u306e\u5897\u91cf<\/li>\n\n\n\n<li><strong>\u4e0d\u598a\u6cbb\u7642<\/strong>\uff1a\u30b4\u30ca\u30c9\u30c8\u30ed\u30d4\u30f3\u88dc\u5145\u306b\u3088\u308b\u6392\u5375\u30fb\u7cbe\u5b50\u5f62\u6210\u306e\u8a98\u5c0e<\/li>\n<\/ul>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u5b9a\u671f\u7684\u306a\u30db\u30eb\u30e2\u30f3\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\uff08IGF1\u3001T4\u3001\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\uff0f\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3001\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\uff09\u306f\u30013\uff5e4\u304b\u6708\u3054\u3068\u306b\u884c\u308f\u308c\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e88\u5f8c | Prognosis<\/h2>\n\n\n\n<p>PROP1\u95a2\u9023CPHD\u306e\u4e88\u5f8c\u306f\u9069\u5207\u306a\u30db\u30eb\u30e2\u30f3\u88dc\u5145\u7642\u6cd5\u306e\u6709\u7121\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u7570\u306a\u308b\u3002GH\u88dc\u5145\u7642\u6cd5\u3092\u53d7\u3051\u305f\u60a3\u8005\u3067\u306f\u6b63\u5e38\u8eab\u9577\u306b\u9054\u3059\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u3001\u9069\u5207\u306a\u30db\u30eb\u30e2\u30f3\u6cbb\u7642\u306b\u3088\u308a\u65e5\u5e38\u751f\u6d3b\u306b\u652f\u969c\u3092\u304d\u305f\u3055\u306a\u3044\u3053\u3068\u304c\u591a\u3044\u3002\u305f\u3060\u3057\u3001ACTH\u6b20\u4e4f\u304c\u9032\u884c\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u9577\u671f\u7684\u306a\u526f\u814e\u6a5f\u80fd\u306e\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002\u307e\u305f\u3001PROP1\u5909\u7570\u3092\u6709\u3059\u308b\u60a3\u8005\u306e\u4e2d\u306b\u306f\u6210\u4eba\u671f\u307e\u3067ACTH\u5206\u6ccc\u304c\u7dad\u6301\u3055\u308c\u308b\u75c7\u4f8b\u3082\u3042\u308b\u304c\u3001\u601d\u6625\u671f\u4ee5\u964d\u306b\u526f\u814e\u4e0d\u5168\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c\u3042\u308b\u305f\u3081\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002\u9069\u5207\u306a\u7ba1\u7406\u306b\u3088\u308a\u3001QOL\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308b\u304c\u3001\u4e00\u751f\u6daf\u306b\u308f\u305f\u308b\u30db\u30eb\u30e2\u30f3\u88dc\u5145\u7642\u6cd5\u3068\u5b9a\u671f\u7684\u306a\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u304c\u5fc5\u8981\u3068\u3055\u308c\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e\uff5cReferences<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1210\/endocr\/bqaf047\">Winningham, A. H., Rhoads, E. C., Brinkmeier, M. L., Vishnopolska, S. A., Kitzman, J. O., Camper, S. A., &amp; P\u00e9rez Mill\u00e1n, M. I. (2025). Role of PROP1 in postnatal pituitary gland maturation. <em>Endocrinology<\/em>, bqaf047. https:\/\/doi.org\/10.1210\/endocr\/bqaf047<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/medicina59030474\">Almatrafi, A., Hibshi, A., &amp; Basit, S. (2023). Association of homozygous prop1 mutation in a saudi family with combined pituitary hormone deficiency. <em>Medicina<\/em>, <em>59<\/em>(3), 474. https:\/\/doi.org\/10.3390\/medicina59030474<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1007\/s42000-023-00510-1\">Zygmunt-G\u00f3rska, A., W\u00f3jcik, M., Gilis-Januszewska, A. <em>et al.<\/em> Comparison of clinical characteristics of a pediatric cohort with combined pituitary hormone deficiency caused by mutation of the <em>PROP1<\/em> gene or of other origins. <em>Hormones<\/em> <strong>23<\/strong>, 69\u201379 (2024). https:\/\/doi.org\/10.1007\/s42000-023-00510-1<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/jcm11247525\">Moalla, M., Mnif-Feki, M., Safi, W., Charfi, N., Mejdoub-Rekik, N., Abid, M., Hadj Kacem, F., &amp; Hadj Kacem, H. (2022). Analysis of prop1 gene in a cohort of tunisian patients with congenital combined pituitary hormone deficiency. <em>Journal of Clinical Medicine<\/em>, <em>11<\/em>(24), 7525. https:\/\/doi.org\/10.3390\/jcm11247525<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1347\/\">Carvalho LR, Nishi MY, Correa FA, et al. PROP1-Related Combined Pituitary Hormone Deficiency. 2000 Dec 7 [Updated 2022 Feb 24]. In: Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews\u00ae [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2025. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1347\/<\/a><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9\uff5cKeywords<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup><sup>PROP1, POU1F1, CPHD2, \u8907\u5408\u578b\u4e0b\u5782\u4f53\u30db\u30eb\u30e2\u30f3\u6b20\u4e4f\u75c7, \u6210\u9577\u30db\u30eb\u30e2\u30f3, GH, \u7532\u72b6\u817a\u523a\u6fc0\u30db\u30eb\u30e2\u30f3, TSH, LH, FSH, ACTH, \u30d7\u30ed\u30e9\u30af\u30c1\u30f3, \u907a\u4f1d\u5b50\u5909\u7570, \u4e0b\u5782\u4f53\u4f4e\u5f62\u6210, \u30db\u30eb\u30e2\u30f3\u88dc\u5145\u7642\u6cd5<\/sup><\/sup><\/p>\n","protected":false},"featured_media":0,"menu_order":0,"template":"page_gd.php","class_list":["post-60379","genetic-diseases","type-genetic-diseases","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/60379","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/genetic-diseases"}],"version-history":[{"count":6,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/60379\/revisions"}],"predecessor-version":[{"id":128116,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/genetic-diseases\/60379\/revisions\/128116"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=60379"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}