{"id":127374,"date":"2026-04-23T13:05:00","date_gmt":"2026-04-23T04:05:00","guid":{"rendered":"https:\/\/nipt-bgi-wp.hiro-test.net\/nipt\/?page_id=127374"},"modified":"2026-04-23T13:11:24","modified_gmt":"2026-04-23T04:11:24","slug":"whole-genome-sequencing","status":"publish","type":"page","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/whole-genome-sequencing\/","title":{"rendered":"\u30db\u30fc\u30eb\u30b2\u30ce\u30e0\u89e3\u6790\uff08WGS\uff09"},"content":{"rendered":"\n

\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u3067\u306f\u3001\u5f93\u6765\u306e\u67d3\u8272\u4f53\u691c\u67fb\u306e\u67a0\u3092\u8d85\u3048\u3001\u80ce\u5150\u306e\u5168\u907a\u4f1d\u60c5\u5831\u3092\u7db2\u7f85\u7684\u306b\u8abf\u3079\u308b\u300c\u30db\u30fc\u30eb\u30b2\u30ce\u30e0\u89e3\u6790\uff08Whole Genome Sequencing\uff1aWGS\uff09\u300d\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u751f\u547d\u306e\u8a2d\u8a08\u56f3\u3067\u3042\u308b\u300c\u30b2\u30ce\u30e0\u300d\u306e\u3059\u3079\u3066\u3092\u30b9\u30ad\u30e3\u30f3\u3059\u308b\u3053\u306e\u691c\u67fb\u306f\u3001\u73fe\u5728\u63d0\u4f9b\u3055\u308c\u3066\u3044\u308b\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u306b\u304a\u3044\u3066\u3001\u6700\u3082\u60c5\u5831\u91cf\u304c\u591a\u304f\u3001\u89e3\u50cf\u5ea6\u306e\u9ad8\u3044\u9078\u629e\u80a2\u3067\u3059\u3002<\/p>\n\n\n\n

\u30db\u30fc\u30eb\u30b2\u30ce\u30e0\u89e3\u6790\uff08WGS\uff09\u3068\u306f\uff1f<\/strong><\/h2>\n\n\n\n

\u907a\u4f1d\u5b50\u306e\u300c\u3059\u3079\u3066\u300d\u3092\u7db2\u7f85\u3059\u308b\u3001\u79d1\u5b66\u306e\u5230\u9054\u70b9<\/strong><\/h3>\n\n\n\n

\u30d2\u30c8\u306e\u30b2\u30ce\u30e0\u306f\u304a\u3088\u305d30\u5104\u500b\u306e\u5869\u57fa\u5bfe\uff08DNA\u306e\u6587\u5b57\uff09\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    \n
  • \u30a8\u30af\u30bd\u30fc\u30e0\u89e3\u6790\uff08WES\uff09\uff1a<\/strong> \u30bf\u30f3\u30d1\u30af\u8cea\u306e\u8a2d\u8a08\u56f3\u3068\u306a\u308b\u300c\u30a8\u30af\u30bd\u30f3\u9818\u57df\uff08\u5168\u4f53\u306e\u7d041\u301c2%\uff09\u300d\u306e\u307f\u3092\u52b9\u7387\u7684\u306b\u89e3\u6790\u3057\u307e\u3059\u3002<\/li>\n\n\n\n
  • \u30db\u30fc\u30eb\u30b2\u30ce\u30e0\u89e3\u6790\uff08WGS\uff09\uff1a<\/strong> \u30a8\u30af\u30bd\u30f3\u9818\u57df\u306b\u52a0\u3048\u3001\u3053\u308c\u307e\u3067\u89e3\u6790\u304c\u96e3\u3057\u304b\u3063\u305f\u300c\u30a4\u30f3\u30c8\u30ed\u30f3\uff0b\u975e\u30b3\u30fc\u30c9\u9818\u57df\u300d\u3092\u542b\u3080\u3001\u30b2\u30ce\u30e0\u5168\u57df\uff08100%\uff09\u3092\u89e3\u6790\u5bfe\u8c61\u3068\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n

    \u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u75c5\u6c17\u306e\u767a\u75c7\u306b\u95a2\u308f\u308b\u30b9\u30a4\u30c3\u30c1\u306e\u5f79\u5272\u3092\u679c\u305f\u3059\u9818\u57df\u304c\u3001\u3053\u306e\u300c\u975e\u30b3\u30fc\u30c9\u9818\u57df\u300d\u306b\u3082\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u3066\u3044\u307e\u3059\u3002WGS\u306f\u3001\u6587\u5b57\u901a\u308a\u300c\u4e00\u6587\u5b57\u3082\u6f0f\u3089\u3055\u305a\u306b\u8aad\u307f\u89e3\u304f\u300d\u3053\u3068\u3067\u3001\u3053\u308c\u307e\u3067\u306e\u691c\u67fb\u3067\u306f\u5230\u9054\u3067\u304d\u306a\u304b\u3063\u305f\u5fae\u7d30\u306a\u30ea\u30b9\u30af\u307e\u3067\u3092\u53ef\u8996\u5316\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

    \u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b5\u30fc\uff08NGS\uff09\u306b\u3088\u308b\u9ad8\u6df1\u5ea6\u89e3\u6790<\/strong><\/h2>\n\n\n\n

    \u30db\u30fc\u30eb\u30b2\u30ce\u30e0\u89e3\u6790\u306e\u7cbe\u5ea6\u3092\u652f\u3048\u308b\u306e\u306f\u3001\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b5\u30fc\uff08NGS\uff09\u306b\u3088\u308b\u81a8\u5927\u306a\u30c7\u30fc\u30bf\u306e\u7a4d\u307f\u91cd\u306d\u3067\u3059\u3002<\/p>\n\n\n\n

    \u4fe1\u983c\u6027\u3092\u62c5\u4fdd\u3059\u308b\u6307\u6a19\u300c\u30ab\u30d0\u30ec\u30c3\u30b8\uff08\u6df1\u5ea6\uff09\u300d<\/strong><\/h4>\n\n\n\n

    \u89e3\u6790\u30c7\u30fc\u30bf\u306e\u6b63\u78ba\u6027\u3092\u6e2c\u308b\u6307\u6a19\u3068\u3057\u3066\u300c\u30ab\u30d0\u30ec\u30c3\u30b8\uff08Depth of Coverage\uff09\u300d\u304c\u3042\u308a\u307e\u3059\u3002\u30bf\u30fc\u30b2\u30c3\u30c8\u9818\u57df\u304c\u5e73\u5747\u3057\u3066\u4f55\u56de\u7e70\u308a\u8fd4\u3057\u8aad\u307f\u53d6\u3089\u308c\u305f\u304b\u3092\u793a\u3059\u6570\u5024\u3067\u3042\u308a\u3001\u4ee5\u4e0b\u306e\u6570\u5f0f\u3067\u5b9a\u7fa9\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

    C \uff1d (L \u00d7 N) \uff0f G<\/strong><\/p>\n\n\n\n

      \n
    • L<\/strong>\uff1a1\u56de\u3042\u305f\u308a\u306e\u8aad\u307f\u53d6\u308a\u5869\u57fa\u9577\uff08\u30ea\u30fc\u30c9\u9577\uff09<\/li>\n\n\n\n
    • N<\/strong>\uff1a\u7dcf\u30ea\u30fc\u30c9\u6570<\/li>\n\n\n\n
    • G<\/strong>\uff1a\u30bf\u30fc\u30b2\u30c3\u30c8\u9818\u57df\uff08\u30b2\u30ce\u30e0\u5168\u4f53\uff09\u306e\u7dcf\u5869\u57fa\u5bfe\u6570<\/li>\n<\/ul>\n\n\n\n

      \u30db\u30fc\u30eb\u30b2\u30ce\u30e0\u89e3\u6790\u30d7\u30e9\u30f3\u3067\u306f\u3001\u3053\u306e\u30ab\u30d0\u30ec\u30c3\u30b8\u3092\u6975\u3081\u3066\u9ad8\u304f\u8a2d\u5b9a\u3057\u300130\u5104\u5869\u57fa\u3068\u3044\u3046\u5e83\u5927\u306a\u9818\u57df\u306b\u304a\u3044\u3066\u30ce\u30a4\u30ba\u3092\u6392\u9664\u3057\u305f\u7cbe\u5bc6\u306a\u30c7\u30fc\u30bf\u53d6\u5f97\u3092\u884c\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

      \u691c\u67fb\u30d7\u30e9\u30f3\u306e\u4ed5\u69d8<\/strong><\/h2>\n\n\n\n
      \n \n \n \n \n \n
      \u30d7\u30e9\u30f3\u540d<\/th>\n \u30db\u30fc\u30eb\u30b2\u30ce\u30e0\u89e3\u6790\uff08WGS\uff09\u30d7\u30e9\u30f3<\/td>\n <\/tr>\n
      \u691c\u67fb\u5bfe\u8c61<\/th>\n \u5168\u30b2\u30ce\u30e0\u9818\u57df\uff0830\u5104\u5869\u57fa\u5bfe\u3059\u3079\u3066\uff09<\/td>\n <\/tr>\n
      \u691c\u67fb\u8cbb\u7528<\/th>\n 550,000\u5186\uff08\u7a0e\u8fbc\uff09<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n<\/div>\n\n\n\n


      <\/strong>\u4ed6\u306e\u691c\u67fb\u624b\u6cd5\u3068\u306e\u6bd4\u8f03<\/strong><\/h2>\n\n\n\n
      \n \n \n \n \n \n \n \n
      \u6bd4\u8f03\u9805\u76ee<\/th>\n \u30a8\u30af\u30bd\u30fc\u30e0\u89e3\u6790\uff08WES\uff09<\/th>\n \u30db\u30fc\u30eb\u30b2\u30ce\u30e0\u89e3\u6790\uff08WGS\uff09<\/th>\n <\/tr>\n <\/thead>\n
      \u89e3\u6790\u5bfe\u8c61<\/th>\n \u30a8\u30af\u30bd\u30f3\u9818\u57df\uff08\u7d041\u301c2%\uff09<\/td>\n \u30b2\u30ce\u30e0\u5168\u57df\uff08100%\uff09<\/td>\n <\/tr>\n
      \u60c5\u5831\u91cf<\/th>\n \u65e2\u77e5\u306e\u75be\u60a3\u539f\u56e0\u907a\u4f1d\u5b50\u306b\u7279\u5316<\/td>\n \u5727\u5012\u7684\uff08\u672a\u77e5\u306e\u9818\u57df\u3082\u7db2\u7f85\uff09<\/td>\n <\/tr>\n
      \u69cb\u9020\u7570\u5e38<\/th>\n \u691c\u51fa\u306b\u9650\u754c\u304c\u3042\u308b<\/td>\n \u9ad8\u3044\u691c\u51fa\u80fd\u529b
      \uff08\u5fae\u5c0f\u6b20\u5931<\/a>\u30fb\u91cd\u8907\u306a\u3069\uff09<\/td>\n <\/tr>\n
      \u975e\u30b3\u30fc\u30c9\u9818\u57df<\/th>\n \u89e3\u6790\u5bfe\u8c61\u5916<\/td>\n \u89e3\u6790\u5bfe\u8c61\uff08\u8abf\u7bc0\u9818\u57df\u306a\u3069\uff09<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n<\/div>\n\n\n\n


      <\/strong>\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u3067\u30db\u30fc\u30eb\u30b2\u30ce\u30e0\u89e3\u6790\u3092\u53d7\u3051\u308b\u30e1\u30ea\u30c3\u30c8<\/strong><\/h2>\n\n\n\n

      1. \u89e3\u6790\u5bfe\u8c61\u306e\u6700\u5927\u5316<\/strong><\/h3>\n\n\n\n

      \u67d3\u8272\u4f53\u306e\u300c\u6570\u300d\u306e\u7570\u5e38\u3060\u3051\u3067\u306a\u304f\u3001\u5fae\u5c0f\u306a\u69cb\u9020\u5909\u5316\uff08\u30b3\u30d4\u30fc\u6570\u591a\u578b\uff1aCNV\uff09\u3084\u3001\u7279\u5b9a\u306e\u5358\u4e00\u907a\u4f1d\u5b50\u75be\u60a3\u306e\u30ea\u30b9\u30af\u307e\u3067\u3001\u73fe\u6642\u70b9\u3067\u79d1\u5b66\u7684\u306b\u89e3\u6790\u53ef\u80fd\u306a\u6700\u5927\u7bc4\u56f2\u306e\u60c5\u5831\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

      2. \u56fd\u5185\u81ea\u793e\u30e9\u30dc\u306b\u3088\u308b\u4e00\u8cab\u4f53\u5236<\/strong><\/h3>\n\n\n\n

      \u691c\u4f53\u306f\u6d77\u5916\u3078\u9001\u308b\u3053\u3068\u306a\u304f\u3001\u56fd\u5185\u306e\u9ad8\u5ea6\u89e3\u6790\u62e0\u70b9\u306b\u3066\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u3092\u5b9f\u65bd\u3057\u307e\u3059\u3002\u60c5\u5831\u306e\u6a5f\u5bc6\u6027\u3092\u4fdd\u3061\u3064\u3064\u3001\u8f38\u9001\u306b\u3088\u308b\u691c\u4f53\u52a3\u5316\u306e\u30ea\u30b9\u30af\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u3001\u8fc5\u901f\u306a\u7d50\u679c\u5831\u544a\u3092\u53ef\u80fd\u306b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

      3. \u5c02\u9580\u533b\u306b\u3088\u308b\u30a2\u30d5\u30bf\u30fc\u30d5\u30a9\u30ed\u30fc<\/strong><\/h3>\n\n\n\n

      \u30db\u30fc\u30eb\u30b2\u30ce\u30e0\u89e3\u6790\u306f\u6975\u3081\u3066\u81a8\u5927\u306a\u30c7\u30fc\u30bf\u304c\u5f97\u3089\u308c\u308b\u305f\u3081\u3001\u305d\u306e\u89e3\u91c8\u306b\u306f\u9ad8\u5ea6\u306a\u5c02\u9580\u77e5\u8b58\u304c\u5fc5\u8981\u3067\u3059\u3002\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u3067\u306f\u3001\u89e3\u6790\u7d50\u679c\u306e\u533b\u5b66\u7684\u610f\u7fa9\u306b\u3064\u3044\u3066\u3001\u5c02\u9580\u533b\u304c\u4e01\u5be7\u306b\u3054\u8aac\u660e\u3057\u3001\u3054\u5bb6\u65cf\u306e\u610f\u601d\u6c7a\u5b9a\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

      \u691c\u67fb\u306e\u9650\u754c\u306b\u3064\u3044\u3066<\/strong><\/h2>\n\n\n\n

      \u30db\u30fc\u30eb\u30b2\u30ce\u30e0\u89e3\u6790\u306f\u3001\u4ee5\u4e0b\u306e\u9650\u754c\u70b9\u3092\u3054\u7406\u89e3\u3044\u305f\u3060\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n