{"id":137750,"date":"2026-10-07T06:31:50","date_gmt":"2026-10-06T21:31:50","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/down-syndrome-risk-check\/"},"modified":"2026-10-07T10:15:45","modified_gmt":"2026-10-07T01:15:45","slug":"down-syndrome-risk-check","status":"publish","type":"page","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/down-syndrome-risk-check\/","title":{"rendered":"\u30c0\u30a6\u30f3\u75c7\u306e\u78ba\u7387\u30c1\u30a7\u30c3\u30af\uff5c\u5e74\u9f62\u30fb\u691c\u67fb\u7d50\u679c\u304b\u3089\u300c\u4f55\u4eba\u306b1\u4eba\u300d\u304b\u3092\u8a08\u7b97"},"content":{"rendered":"\n<style>\n.dsrc{--c-main:#e54c84;--c-soft:#fdeef3;--c-line:#e6d9de;--c-text:#333;--c-sub:#666;--c-ok:#2f7d5b;--c-warn:#b5462f;max-width:760px;margin:0 auto;color:var(--c-text);font-size:16px;line-height:1.8}\n.dsrc *{box-sizing:border-box}\n.dsrc .lead{background:var(--c-soft);border-radius:12px;padding:1rem 1.25rem;margin:0 0 1.5rem}\n.dsrc .lead p{margin:.25rem 0}\n.dsrc fieldset{border:1px solid var(--c-line);border-radius:12px;padding:1rem 1.25rem 1.25rem;margin:0 0 1.25rem}\n.dsrc legend{font-weight:bold;color:var(--c-main);padding:0 .5rem;font-size:1.05rem}\n.dsrc label{display:block;margin:.5rem 0}\n.dsrc .hint{font-size:.85rem;color:var(--c-sub);margin:.25rem 0 0}\n.dsrc input[type=number],.dsrc select{font-size:16px;padding:.5rem .6rem;border:1px solid #bbb;border-radius:8px;max-width:100%}\n.dsrc input[type=number]{width:7rem}\n.dsrc .row{display:flex;flex-wrap:wrap;align-items:center;gap:.5rem}\n.dsrc .chk{display:flex;gap:.5rem;align-items:flex-start;margin:.4rem 0}\n.dsrc .chk input{margin-top:.45rem;flex-shrink:0;width:1.1rem;height:1.1rem}\n.dsrc .ratio{display:none;margin:.5rem 0 0 1.6rem}\n.dsrc .btn{display:block;width:100%;max-width:420px;margin:1.5rem auto;padding:1rem;border:0;border-radius:999px;background:var(--c-main);color:#fff;font-size:1.15rem;font-weight:bold;letter-spacing:.1rem;cursor:pointer;box-shadow:0 .4rem .6rem #e54c8444}\n.dsrc .err{color:var(--c-warn);font-weight:bold;text-align:center}\n.dsrc #dsrc-result{display:none;border:2px solid var(--c-main);border-radius:16px;padding:1.25rem;margin:1.5rem 0}\n.dsrc .big{text-align:center;margin:.5rem 0 1rem}\n.dsrc .big .lbl{display:block;color:var(--c-sub);font-size:.95rem}\n.dsrc .big .num{display:block;font-size:2.4rem;font-weight:bold;color:var(--c-main);line-height:1.3}\n.dsrc .big .pct{display:block;font-size:1rem;color:var(--c-sub)}\n.dsrc .cmp{background:#fff;border:1px solid var(--c-line);border-radius:12px;padding:1rem 1.1rem;margin:0 0 1rem}\n.dsrc .cmp-h{text-align:center;margin:0 0 .75rem;font-size:.95rem}\n.dsrc .cmp-h b{display:block;font-size:2rem;color:var(--c-main);line-height:1.3}\n.dsrc .bar{margin:.6rem 0}\n.dsrc .bar .bl{display:flex;justify-content:space-between;gap:.5rem;font-size:.85rem;margin-bottom:.2rem}\n.dsrc .bar .bl span:last-child{white-space:nowrap;font-weight:bold}\n.dsrc .bar .track{background:#f1eef0;border-radius:6px;height:22px;overflow:hidden}\n.dsrc .bar .fill{height:100%;border-radius:6px;background:#c9bfc4;min-width:4px;transition:width .6s ease}\n.dsrc .bar.you .bl{color:var(--c-main);font-weight:bold}\n.dsrc .bar.you .fill{background:var(--c-main)}\n.dsrc .bar.base .fill{background:#8fb8a8}\n.dsrc .cmp-note{font-size:.8rem;color:var(--c-sub);margin:.75rem 0 0}\n.dsrc .zero{border-left:5px solid var(--c-main);background:var(--c-soft);border-radius:4px;padding:.75rem 1rem;margin:1rem 0 0}\n.dsrc .zero p{margin:.3rem 0;font-size:.95rem}\n.dsrc .zero .zt{font-weight:bold;color:var(--c-main);font-size:1.02rem}\n.dsrc .breakdown{font-size:.9rem;background:#f7f7f7;border-radius:8px;padding:.75rem 1rem;margin:1rem 0}\n.dsrc .breakdown ul{margin:.25rem 0;padding-left:1.2rem}\n.dsrc .alert{border-left:5px solid var(--c-warn);background:#fbefec;padding:.75rem 1rem;margin:1rem 0;border-radius:4px}\n.dsrc h3.dsrc-h{font-size:1.15rem;margin:1.5rem 0 .5rem;padding:0 0 .25rem;border-bottom:2px solid var(--c-main)}\n.dsrc .opt{border:1px solid var(--c-line);border-radius:12px;padding:.75rem 1rem;margin:.6rem 0}\n.dsrc .opt.now{border-color:var(--c-main);background:var(--c-soft)}\n.dsrc .opt .t{font-weight:bold}\n.dsrc .opt .tag{display:inline-block;font-size:.75rem;padding:0 .5rem;border-radius:999px;margin-left:.4rem;vertical-align:middle;background:#eee;color:#555}\n.dsrc .opt.now .tag{background:var(--c-main);color:#fff}\n.dsrc .opt p{margin:.25rem 0;font-size:.95rem}\n.dsrc .cta{text-align:center;margin:1.5rem 0}\n.dsrc .cta a{display:inline-block;margin:.4rem;padding:.9rem 1.5rem;border-radius:999px;text-decoration:none;font-weight:bold;min-width:260px}\n.dsrc .cta a.p{background:#f0a3b8;color:#fff}\n.dsrc .cta a.s{border:2px solid #f0a3b8;color:var(--c-main);background:#fff}\n.dsrc table.ref{width:100%;border-collapse:collapse;font-size:.95rem;margin:.5rem 0}\n.dsrc table.ref th,.dsrc table.ref td{border:1px solid var(--c-line);padding:.4rem .6rem;text-align:center}\n.dsrc table.ref th{background:var(--c-soft)}\n.dsrc .notes{font-size:.85rem;color:var(--c-sub)}\n.dsrc .notes li{margin:.25rem 0}\n@media (max-width:500px){.dsrc fieldset{padding:.75rem .9rem 1rem}.dsrc .big .num{font-size:2rem}.dsrc .cta a{min-width:0;width:100%;margin:.4rem 0}}\n<\/style>\n\n<div class=\"dsrc\" id=\"dsrc\">\n<div class=\"lead\">\n<p>\u5e74\u9f62\u3084\u598a\u5a20\u7d4c\u904e\u3001\u3053\u308c\u307e\u3067\u306b\u53d7\u3051\u305f\u691c\u67fb\u306e\u7d50\u679c\u3092\u5165\u308c\u308b\u3068\u3001\u8d64\u3061\u3083\u3093\u304c<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\uff0821\u30c8\u30ea\u30bd\u30df\u30fc\uff09\u3067\u751f\u307e\u308c\u308b\u78ba\u7387\u306e<strong>\u76ee\u5b89<\/strong>\u3092\u300c\u4f55\u4eba\u306b1\u4eba\u300d\u3067\u8868\u793a\u3057\u3001\u4eca\u306e\u6642\u671f\u306b\u53d7\u3051\u3089\u308c\u308b\u691c\u67fb\u3092\u3054\u6848\u5185\u3057\u307e\u3059\u3002<\/p>\n<p class=\"hint\">\u5165\u529b\u3057\u305f\u5185\u5bb9\u306f\u3053\u306e\u30da\u30fc\u30b8\u306e\u4e2d\u3060\u3051\u3067\u8a08\u7b97\u3057\u3001\u3069\u3053\u306b\u3082\u9001\u4fe1\u30fb\u4fdd\u5b58\u3055\u308c\u307e\u305b\u3093\u3002\u7d50\u679c\u306f\u533b\u5b66\u7684\u306a\u8a3a\u65ad\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<\/div>\n\n<form id=\"dsrc-form\" novalidate>\n<fieldset>\n<legend>1. \u304a\u6bcd\u3055\u3093\u306e\u5e74\u9f62<\/legend>\n<div class=\"row\"><label for=\"dsrc-age\" style=\"margin:0\">\u51fa\u7523\u4e88\u5b9a\u65e5\u306e\u6642\u70b9\u3067\u306e\u5e74\u9f62<\/label><input type=\"number\" id=\"dsrc-age\" min=\"15\" max=\"55\" step=\"1\" inputmode=\"numeric\" placeholder=\"\u4f8b\uff1a36\"> \u6b73<\/div>\n<div class=\"chk\"><input type=\"checkbox\" id=\"dsrc-donor\"><label for=\"dsrc-donor\" style=\"margin:0\">\u5375\u5b50\u63d0\u4f9b\u306b\u3088\u308b\u598a\u5a20<span class=\"hint\" style=\"display:block\"><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\u306e\u78ba\u7387\u306f\u5375\u5b50\u306e\u5e74\u9f62\u3067\u6c7a\u307e\u308a\u307e\u3059\u3002\u63d0\u4f9b\u8005\u306e\u63a1\u5375\u6642\u306e\u5e74\u9f62\u3092\u5165\u308c\u3066\u304f\u3060\u3055\u3044\u3002<\/span><\/label><\/div>\n<div class=\"row ratio\" id=\"dsrc-donor-box\"><label for=\"dsrc-donor-age\" style=\"margin:0\">\u5375\u5b50\u63d0\u4f9b\u8005\u306e\u63a1\u5375\u6642\u306e\u5e74\u9f62<\/label><input type=\"number\" id=\"dsrc-donor-age\" min=\"18\" max=\"45\" step=\"1\" inputmode=\"numeric\"> \u6b73<\/div>\n<\/fieldset>\n\n<fieldset>\n<legend>2. \u598a\u5a20\u9031\u6570<\/legend>\n<div class=\"row\"><label for=\"dsrc-week\" style=\"margin:0\">\u4eca\u65e5\u306e\u598a\u5a20\u9031\u6570<\/label><input type=\"number\" id=\"dsrc-week\" min=\"4\" max=\"41\" step=\"1\" inputmode=\"numeric\" placeholder=\"\u4f8b\uff1a11\"> \u9031<\/div>\n<p class=\"hint\">\u4eca\u53d7\u3051\u3089\u308c\u308b\u691c\u67fb\u306e\u3054\u6848\u5185\u306b\u4f7f\u3044\u307e\u3059\u3002\u308f\u304b\u3089\u306a\u3051\u308c\u3070\u7a7a\u6b04\u3067\u69cb\u3044\u307e\u305b\u3093\u3002<\/p>\n<\/fieldset>\n\n<fieldset>\n<legend>3. \u65e2\u5f80\u6b74\uff08\u3042\u3066\u306f\u307e\u308b\u3082\u306e\u3059\u3079\u3066\uff09<\/legend>\n<div class=\"chk\"><input type=\"checkbox\" id=\"dsrc-h-t21\"><label for=\"dsrc-h-t21\" style=\"margin:0\">\u4ee5\u524d\u306e\u598a\u5a20\u3067\u3001\u8d64\u3061\u3083\u3093\u304c<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\uff0821\u30c8\u30ea\u30bd\u30df\u30fc\uff09\u3060\u3063\u305f<\/label><\/div>\n<div class=\"chk\"><input type=\"checkbox\" id=\"dsrc-h-tri\"><label for=\"dsrc-h-tri\" style=\"margin:0\">\u4ee5\u524d\u306e\u598a\u5a20\u3067\u3001\u8d64\u3061\u3083\u3093\u304c<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u30fb<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u306a\u3069\u4ed6\u306e\u67d3\u8272\u4f53\u306e\u75c5\u6c17\u3060\u3063\u305f<\/label><\/div>\n<div class=\"chk\"><input type=\"checkbox\" id=\"dsrc-h-trans\"><label for=\"dsrc-h-trans\" style=\"margin:0\">\u3054\u592b\u5a66\u306e\u3069\u3061\u3089\u304b\u304c\u300121\u756a\u67d3\u8272\u4f53\u304c\u304b\u304b\u308f\u308b\u300c\u8ee2\u5ea7\u300d\u306e\u4fdd\u56e0\u8005\u3068\u8a00\u308f\u308c\u3066\u3044\u308b<\/label><\/div>\n<\/fieldset>\n\n<fieldset>\n<legend>4. <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u6b74<\/legend>\n<div class=\"row\"><label for=\"dsrc-mc\" style=\"margin:0\">\u3053\u308c\u307e\u3067\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306e\u56de\u6570<\/label>\n<select id=\"dsrc-mc\"><option value=\"0\">\u306a\u3057<\/option><option value=\"1\">1\u56de<\/option><option value=\"2\">2\u56de<\/option><option value=\"3\">3\u56de\u4ee5\u4e0a<\/option><\/select><\/div>\n<\/fieldset>\n\n<fieldset>\n<legend>5. \u30a8\u30b3\u30fc\u691c\u67fb\u306e\u7d50\u679c<\/legend>\n<p class=\"hint\" style=\"margin-top:0\">\u533b\u5e2b\u304b\u3089\u8a00\u308f\u308c\u305f\u3053\u3068\u306b\u30c1\u30a7\u30c3\u30af\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u4f55\u3082\u8a00\u308f\u308c\u3066\u3044\u306a\u3051\u308c\u3070\u30c1\u30a7\u30c3\u30af\u4e0d\u8981\u3067\u3059\u3002<\/p>\n<div class=\"chk\"><input type=\"checkbox\" id=\"dsrc-e-nt\"><label for=\"dsrc-e-nt\" style=\"margin:0\">\u9996\u306e\u3046\u3057\u308d\u306e\u3080\u304f\u307f\uff08NT\uff09\u304c\u539a\u3044\u3068\u8a00\u308f\u308c\u305f\uff08\u598a\u5a2011\u301c13\u9031\u3054\u308d\uff09<\/label><\/div>\n<div class=\"chk\"><input type=\"checkbox\" id=\"dsrc-e-heart\"><label for=\"dsrc-e-heart\" style=\"margin:0\">\u5fc3\u81d3\u306a\u3069\u3001\u4f53\u306e\u3064\u304f\u308a\u306b\u7570\u5e38\u304c\u3042\u308b\u3068\u8a00\u308f\u308c\u305f<\/label><\/div>\n<div class=\"chk\"><input type=\"checkbox\" id=\"dsrc-e-nb\" data-lr=\"6.58\"><label for=\"dsrc-e-nb\" style=\"margin:0\">\u9f3b\u306e\u9aa8\u304c\u898b\u3048\u306a\u3044\u30fb\u5c0f\u3055\u3044\u3068\u8a00\u308f\u308c\u305f<\/label><\/div>\n<div class=\"chk\"><input type=\"checkbox\" id=\"dsrc-e-nf\" data-lr=\"3.79\"><label for=\"dsrc-e-nf\" style=\"margin:0\">\u9996\u306e\u3046\u3057\u308d\u306e\u76ae\u819a\u304c\u539a\u3044\u3068\u8a00\u308f\u308c\u305f\uff08\u598a\u5a2016\u9031\u4ee5\u964d\uff09<\/label><\/div>\n<div class=\"chk\"><input type=\"checkbox\" id=\"dsrc-e-vm\" data-lr=\"3.81\"><label for=\"dsrc-e-vm\" style=\"margin:0\">\u8133\u306e\u8133\u5ba4\u304c\u5c11\u3057\u5e83\u3044\u3068\u8a00\u308f\u308c\u305f<\/label><\/div>\n<div class=\"chk\"><input type=\"checkbox\" id=\"dsrc-e-arsa\" data-lr=\"3.94\"><label for=\"dsrc-e-arsa\" style=\"margin:0\">\u53f3\u306e\u9396\u9aa8\u4e0b\u52d5\u8108\u306e\u8d70\u308a\u65b9\u304c\u9055\u3046\u3068\u8a00\u308f\u308c\u305f<\/label><\/div>\n<div class=\"chk\"><input type=\"checkbox\" id=\"dsrc-e-bowel\" data-lr=\"1.65\"><label for=\"dsrc-e-bowel\" style=\"margin:0\">\u8178\u304c\u767d\u304f\u5149\u3063\u3066\u898b\u3048\u308b\uff08\u9ad8\u8f1d\u5ea6\u8178\u7ba1\uff09\u3068\u8a00\u308f\u308c\u305f<\/label><\/div>\n<\/fieldset>\n\n<fieldset>\n<legend>6. \u30af\u30a2\u30c8\u30ed\u691c\u67fb\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/maternal-serum-screening-test\/\">\u6bcd\u4f53\u8840\u6e05\u30de\u30fc\u30ab\u30fc<\/a>\uff09\u306e\u7d50\u679c<\/legend>\n<label><input type=\"radio\" name=\"dsrc-q\" value=\"none\" checked> \u53d7\u3051\u3066\u3044\u306a\u3044<\/label>\n<label><input type=\"radio\" name=\"dsrc-q\" value=\"ratio\"> \u53d7\u3051\u305f\uff08\u7d50\u679c\u306e\u300c21\u30c8\u30ea\u30bd\u30df\u30fc\u300d\u306e\u78ba\u7387\u306e\u6570\u5b57\u304c\u308f\u304b\u308b\uff09<\/label>\n<div class=\"row ratio\" id=\"dsrc-q-ratio-box\">1 \/ <input type=\"number\" id=\"dsrc-q-ratio\" min=\"2\" max=\"100000\" step=\"1\" inputmode=\"numeric\" placeholder=\"\u4f8b\uff1a295\"><span class=\"hint\">\u7d50\u679c\u7528\u7d19\u306e\u300c<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7\u5019\u7fa4<\/a>\uff0821\u30c8\u30ea\u30bd\u30df\u30fc\uff09\u300d\u306e\u6b04\u306e\u6570\u5b57<\/span><\/div>\n<label><input type=\"radio\" name=\"dsrc-q\" value=\"pos\"> \u53d7\u3051\u305f\uff08\u6570\u5b57\u306f\u308f\u304b\u3089\u306a\u3044\u304c\u300c\u967d\u6027\u300d\u300c\u78ba\u7387\u304c\u9ad8\u3044\u300d\u3068\u8a00\u308f\u308c\u305f\uff09<\/label>\n<label><input type=\"radio\" name=\"dsrc-q\" value=\"neg\"> \u53d7\u3051\u305f\uff08\u6570\u5b57\u306f\u308f\u304b\u3089\u306a\u3044\u304c\u300c\u9670\u6027\u300d\u300c\u78ba\u7387\u306f\u4f4e\u3044\u300d\u3068\u8a00\u308f\u308c\u305f\uff09<\/label>\n<\/fieldset>\n\n<p class=\"err\" id=\"dsrc-err\" role=\"alert\"><\/p>\n<button type=\"submit\" class=\"btn\">\u78ba\u7387\u3092\u8a08\u7b97\u3059\u308b<\/button>\n<\/form>\n\n<div id=\"dsrc-result\" aria-live=\"polite\">\n<div class=\"big\"><span class=\"lbl\">\u8d64\u3061\u3083\u3093\u304c<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\u3067\u751f\u307e\u308c\u308b\u78ba\u7387\u306f<br>20\u6b73\u306e\u5065\u5eb7\u306a\u598a\u5a66\u3055\u3093\u3068\u6bd4\u3079\u3066<\/span><span class=\"num\" id=\"dsrc-num\"><\/span><span class=\"pct\" id=\"dsrc-pct\"><\/span><\/div>\n<div class=\"cmp\" id=\"dsrc-cmp\"><\/div>\n<div id=\"dsrc-alerts\"><\/div>\n<div class=\"breakdown\" id=\"dsrc-breakdown\"><\/div>\n\n<h3 class=\"dsrc-h\">\u4eca\u3067\u304d\u308b\u3053\u3068<\/h3>\n<div id=\"dsrc-options\"><\/div>\n\n<div class=\"cta\">\n<a class=\"p\" href=\"https:\/\/mypage-nipt-reservation.hiro-clinic.or.jp\/registration\" target=\"_blank\" rel=\"noopener\">NIPT\u306e\u7a7a\u304d\u72b6\u6cc1\u3092\u78ba\u8a8d\u3057\u3066\u4e88\u7d04\u3059\u308b<\/a>\n<a class=\"s\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/genetic-counseling\/\">\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306b\u3064\u3044\u3066<\/a>\n<\/div>\n<p class=\"notes\" style=\"text-align:center\"><a href=\"#dsrc-form\" id=\"dsrc-again\">\u5165\u529b\u3092\u3084\u308a\u76f4\u3059<\/a><\/p>\n<\/div>\n\n<h3 class=\"dsrc-h\">\u53c2\u8003\uff1a\u5e74\u9f62\u3054\u3068\u306e\u30c0\u30a6\u30f3\u75c7\u306e\u78ba\u7387\uff08\u51fa\u7523\u6642\uff09<\/h3>\n<table class=\"ref\" id=\"dsrc-ref\"><thead><tr><th>\u51fa\u7523\u6642\u306e\u5e74\u9f62<\/th><th>\u78ba\u7387\u306e\u76ee\u5b89<\/th><th>\u51fa\u7523\u6642\u306e\u5e74\u9f62<\/th><th>\u78ba\u7387\u306e\u76ee\u5b89<\/th><\/tr><\/thead><tbody><\/tbody><\/table>\n\n<h3 class=\"dsrc-h\">\u8a08\u7b97\u306e\u3057\u304b\u305f\u3068\u6ce8\u610f<\/h3>\n<ul class=\"notes\">\n<li>\u5e74\u9f62\u3054\u3068\u306e\u78ba\u7387\u306f\u3001\u51fa\u7523\u6642\u70b9\u3067\u306e\u5024\u3067\u3059\uff3b1\uff3d\u3002\u598a\u5a20\u4e2d\u306e\u6642\u70b9\u3067\u306f\u3001\u305d\u306e\u5f8c\u306b\u81ea\u7136\u306b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u3059\u308b\u5206\u3092\u542b\u3080\u305f\u3081\u3001\u51fa\u7523\u6642\u3088\u308a\u9ad8\u304f\u306a\u308a\u307e\u3059\uff08\u598a\u5a2012\u9031\u3067\u7d0430%\u300116\u9031\u3067\u7d0421%\u9ad8\u3044\uff09\uff3b2\uff3d\u3002<\/li>\n<li>\u4ee5\u524d\u306e\u598a\u5a20\u3067<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\u304c\u3042\u3063\u305f\u5834\u5408\u306f\u3001\u5e74\u9f62\u306b\u3088\u308b\u78ba\u7387\u306b\u300130\u6b73\u672a\u6e80\u3067\u306f8.0\u500d\u300130\u6b73\u4ee5\u4e0a\u3067\u306f2.1\u500d\u3092\u639b\u3051\u3066\u3044\u307e\u3059\u3002\u4ed6\u306e\u30c8\u30ea\u30bd\u30df\u30fc\uff0818\u30fb<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u306a\u3069\uff09\u304c\u3042\u3063\u305f\u5834\u5408\u306f1.6\u500d\u3067\u3059\uff3b3\uff3d\u3002\u82e5\u3044\u5e74\u9f62\u307b\u3069\u518d\u767a\u306e\u4e0a\u4e57\u305b\u304c\u5927\u304d\u3044\u3053\u3068\u306f\u3001\u82f1\u56fd\u306e\u767b\u9332\u30c7\u30fc\u30bf\u3067\u3082\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff3b4\uff3d\u3002<\/li>\n<li><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306e\u56de\u6570\u3067\u306f\u78ba\u7387\u3092\u5909\u3048\u3066\u3044\u307e\u305b\u3093\u3002<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u3092\u304f\u308a\u8fd4\u3057\u3066\u3044\u308b\u5834\u5408\u306f\u3001\u3054\u592b\u5a66\u306e\u67d3\u8272\u4f53\u306e\u691c\u67fb\u304c\u691c\u8a0e\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\uff3b5\uff3d\u3002<\/li>\n<li>\u30a8\u30b3\u30fc\u306e\u6240\u898b\u306f\u3001\u305d\u306e\u6240\u898b\u304c\u5358\u72ec\u3067\u898b\u3064\u304b\u3063\u305f\u3068\u304d\u306e\u5c24\u5ea6\u6bd4\uff08\u9f3b\u9aa8\u306e\u4f4e\u5f62\u6210 6.58\u3001\u9996\u306e\u3046\u3057\u308d\u306e\u76ae\u819a\u306e\u80a5\u539a 3.79\u3001\u8133\u5ba4\u306e\u62e1\u5927 3.81\u3001\u53f3\u9396\u9aa8\u4e0b\u52d5\u8108\u306e\u8d77\u59cb\u7570\u5e38 3.94\u3001\u9ad8\u8f1d\u5ea6\u8178\u7ba1 1.65\uff09\u3092\u639b\u3051\u3066\u3044\u307e\u3059\uff3b6\uff3d\uff3b7\uff3d\u3002\u8907\u6570\u3042\u308b\u5834\u5408\u306f\u639b\u3051\u5408\u308f\u305b\u305f\u76ee\u5b89\u3067\u3059\u3002NT\uff08\u9996\u306e\u3080\u304f\u307f\uff09\u306e\u80a5\u539a\u3084\u4f53\u306e\u3064\u304f\u308a\u306e\u7570\u5e38\u306f\u3001\u7a0b\u5ea6\u306b\u3088\u3063\u3066\u610f\u5473\u304c\u5927\u304d\u304f\u5909\u308f\u308b\u305f\u3081\u3001\u6570\u5b57\u306b\u306f\u542b\u3081\u3066\u3044\u307e\u305b\u3093\u3002<\/li>\n<li>\u30af\u30a2\u30c8\u30ed\u691c\u67fb\u306e\u6570\u5b57\u304c\u3042\u308b\u5834\u5408\u306f\u3001\u5e74\u9f62\u3092\u542b\u3081\u3066\u8a08\u7b97\u3055\u308c\u305f\u5024\u306a\u306e\u3067\u3001\u305d\u308c\u3092\u51fa\u767a\u70b9\u306b\u3057\u307e\u3059\u3002\u6570\u5b57\u304c\u306a\u3044\u5834\u5408\u306f\u3001\u691c\u51fa\u738781%\u30fb\u507d\u967d\u6027\u73875%\uff3b8\uff3d\u304b\u3089\u3001\u967d\u6027\u306716\u500d\u3001\u9670\u6027\u30670.2\u500d\u3068\u3057\u3066\u8a08\u7b97\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n<li>\u5375\u5b50\u63d0\u4f9b\u306b\u3088\u308b\u598a\u5a20\u3067\u306f\u3001\u78ba\u7387\u306f\u5375\u5b50\u63d0\u4f9b\u8005\u306e\u5e74\u9f62\u3067\u6c7a\u307e\u308a\u307e\u3059\uff3b9\uff3d\u3002<\/li>\n<li>\u3053\u306e\u7d50\u679c\u306f\u7d71\u8a08\u306b\u3082\u3068\u3065\u304f\u76ee\u5b89\u3067\u3001\u8d64\u3061\u3083\u3093\u304c<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\u304b\u3069\u3046\u304b\u3092\u6c7a\u3081\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u306f\u3063\u304d\u308a\u77e5\u308b\u306b\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-clinic\/amniocentesis\/\">\u7f8a\u6c34\u691c\u67fb<\/a>\u306a\u3069\u306e\u78ba\u5b9a\u7684\u691c\u67fb\u304c\u5fc5\u8981\u3067\u3059\u3002\u6c17\u306b\u306a\u308b\u3053\u3068\u306f\u4e3b\u6cbb\u533b\u3084\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u306e\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002<\/li>\n<\/ul>\n\n<h3 class=\"dsrc-h\">\u6839\u62e0\u3068\u306a\u308b\u8ad6\u6587<\/h3>\n<ol class=\"notes\" style=\"padding-left:1.8rem;word-break:break-word\">\n<li>Morris JK, Mutton DE, Alberman E. Revised estimates of the maternal age specific live birth prevalence of Down&#8217;s syndrome. <i>J Med Screen<\/i>. 2002;9(1):2-6. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11943789\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a><\/li>\n<li>Snijders RJ, Sundberg K, Holzgreve W, Henry G, Nicolaides KH. Maternal age- and gestation-specific risk for trisomy 21. <i>Ultrasound Obstet Gynecol<\/i>. 1999;13(3):167-70. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10204206\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a><\/li>\n<li>Warburton D, Dallaire L, Thangavelu M, Ross L, Levin B, Kline J. Trisomy recurrence: a reconsideration based on North American data. <i>Am J Hum Genet<\/i>. 2004;75(3):376-85. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15248154\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a><\/li>\n<li>Morris JK, Mutton DE, Alberman E. Recurrences of free trisomy 21: analysis of data from the National Down Syndrome Cytogenetic Register. <i>Prenat Diagn<\/i>. 2005;25(12):1120-8. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16231400\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a><\/li>\n<li>ESHRE Guideline Group on RPL. ESHRE guideline: recurrent pregnancy loss: an update in 2022. <i>Hum Reprod Open<\/i>. 2023;2023(1):hoad002. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36873081\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a><\/li>\n<li>Agathokleous M, Chaveeva P, Poon LC, Kosinski P, Nicolaides KH. Meta-analysis of second-trimester markers for trisomy 21. <i>Ultrasound Obstet Gynecol<\/i>. 2013;41(3):247-61. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23208748\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a><\/li>\n<li>Society for Maternal-Fetal Medicine. SMFM Consult Series #57: Evaluation and management of isolated soft ultrasound markers for aneuploidy in the second trimester. <i>Am J Obstet Gynecol<\/i>. 2021;225(4):B2-B15. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34171388\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a><\/li>\n<li>Malone FD, Canick JA, Ball RH, et al. First-trimester or second-trimester screening, or both, for Down&#8217;s syndrome (FASTER). <i>N Engl J Med<\/i>. 2005;353(19):2001-11. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16282175\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a><\/li>\n<li>Donnenfeld AE, Icke KV, Pargas C, Dowman C. Biochemical screening for aneuploidy in ovum donor pregnancies. <i>Am J Obstet Gynecol<\/i>. 2002;187(5):1222-5. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12439508\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a><\/li>\n<li>Gil MM, Accurti V, Santacruz B, Plana MN, Nicolaides KH. Analysis of cell-free DNA in maternal blood in screening for aneuploidies: updated meta-analysis. <i>Ultrasound Obstet Gynecol<\/i>. 2017;50(3):302-14. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28397325\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>\uff08NIPT\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\u306e\u691c\u51fa\u738799.7%\u30fb\u507d\u967d\u6027\u73870.04%\uff09<\/li>\n<li>Salomon LJ, Sotiriadis A, Wulff CB, Odibo A, Akolekar R. Risk of miscarriage following amniocentesis or chorionic villus sampling: systematic review of literature and updated meta-analysis. <i>Ultrasound Obstet Gynecol<\/i>. 2019;54(4):442-51. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31124209\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-clinic\/amniocentesis\/\">\u7f8a\u6c34\u691c\u67fb<\/a>0.30%\u30fb<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chorionic-villus-test\/\">\u7d68\u6bdb\u691c\u67fb<\/a>0.20%\uff09<\/li>\n<li>American College of Obstetricians and Gynecologists. Screening for fetal chromosomal abnormalities. Practice Bulletin No. 226. <i>Obstet Gynecol<\/i>. 2020;136(4):e48-e69. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32804883\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a><\/li>\n<\/ol>\n<\/div>\n\n<script>\n(function(){\n  var root=document.getElementById('dsrc'); if(!root) return;\n  var $=function(id){return document.getElementById(id)};\n  \/\/ Morris JK, Mutton DE, Alberman E. J Med Screen 2002;9:2-6 \u2014 maternal age-specific live-birth prevalence of Down syndrome\n  function ageRisk(a){return 1\/(1+Math.exp(7.330-4.211\/(1+Math.exp(-0.282*(a-37.23)))))}\n  function oneIn(p){var n=1\/p;return n>=1000?Math.round(n\/10)*10:Math.round(n)}\n  function fmt(n){return n.toLocaleString('ja-JP')}\n  function pct(p){var v=p*100;return v>=1?v.toFixed(1):v>=0.1?v.toFixed(2):v.toFixed(3)}\n\n  \/\/ \u53c2\u8003\u8868\n  var ages=[20,25,30,32,34,35,36,37,38,39,40,41,42,43,44,45],tb=$('dsrc-ref').tBodies[0],half=Math.ceil(ages.length\/2);\n  for(var i=0;i<half;i++){\n    var tr=document.createElement('tr'),h='';\n    [ages[i],ages[i+half]].forEach(function(a){h+=a?'<td>'+a+'\u6b73<\/td><td>'+fmt(oneIn(ageRisk(a)))+'\u4eba\u306b1\u4eba<\/td>':'<td><\/td><td><\/td>'});\n    tr.innerHTML=h;tb.appendChild(tr);\n  }\n\n  $('dsrc-donor').addEventListener('change',function(){$('dsrc-donor-box').style.display=this.checked?'flex':'none'});\n  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alerts.push('<strong>NT\uff08\u9996\u306e\u3080\u304f\u307f\uff09\u306e\u80a5\u539a\u3084\u4f53\u306e\u3064\u304f\u308a\u306e\u7570\u5e38\u306f\u3001\u3053\u306e\u6570\u5b57\u306b\u306f\u542b\u307e\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/strong>\u7a0b\u5ea6\u306b\u3088\u3063\u3066\u306f\u30c0\u30a6\u30f3\u75c7\u306a\u3069\u306e\u67d3\u8272\u4f53\u306e\u75c5\u6c17\u306e\u78ba\u7387\u304c\u5927\u304d\u304f\u4e0a\u304c\u308b\u305f\u3081\u3001\u6570\u5b57\u306b\u304b\u304b\u308f\u3089\u305a\u65e9\u3081\u306b\u4e3b\u6cbb\u533b\u3084\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002');\n    if(mc>=2) alerts.push('\u6d41\u7523\u3092'+(mc>=3?'3\u56de\u4ee5\u4e0a':'2\u56de')+'\u7d4c\u9a13\u3055\u308c\u3066\u3044\u308b\u5834\u5408\u306f\u3001\u3054\u592b\u5a66\u306e\u67d3\u8272\u4f53\u306e\u691c\u67fb\uff08\u8ee2\u5ea7\u306e\u6709\u7121\u306a\u3069\uff09\u304c\u691c\u8a0e\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\uff3b5\uff3d\u3002\u4e3b\u6cbb\u533b\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002');\n\n    var n=oneIn(p);\n    $('dsrc-pct').textContent='\u78ba\u7387\u306e\u76ee\u5b89\uff08\u51fa\u7523\u6642\uff09\uff1a'+fmt(n)+'\u4eba\u306b1\u4eba\uff08\u7d04'+pct(p)+'%\uff09';\n    \/\/ 20\u6b73\u306e\u5065\u5eb7\u306a\u598a\u5a66\u3055\u3093\uff08\u65e2\u5f80\u30fb\u6240\u898b\u306a\u3057\uff09\u30921\u500d\u3068\u3057\u305f\u68d2\u30b0\u30e9\u30d5\n    var p20=ageRisk(20);\n    function times(r){return r>=10?fmt(Math.round(r)):(r>=1?r.toFixed(1):r.toFixed(2))}\n    var 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{t:'\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0',from:0,to:null,d:'\u691c\u67fb\u3092\u53d7\u3051\u308b\u304b\u3069\u3046\u304b\u3001\u7d50\u679c\u3092\u3069\u3046\u53d7\u3051\u3068\u3081\u308b\u304b\u3092\u3001\u5c02\u9580\u306e\u30b9\u30bf\u30c3\u30d5\u3068\u4e00\u7dd2\u306b\u8003\u3048\u307e\u3059\u3002\u598a\u5a20\u4e2d\u3044\u3064\u3067\u3082\u3001\u691c\u67fb\u306e\u524d\u3067\u3082\u5f8c\u3067\u3082\u53d7\u3051\u3089\u308c\u307e\u3059\u3002'}\n    ];\n    if(q==='ratio'||q==='pos'||q==='neg') opts[1].d='\u3059\u3067\u306b\u53d7\u3051\u3066\u3044\u308b\u691c\u67fb\u3067\u3059\u3002'+opts[1].d;\n    $('dsrc-options').innerHTML=opts.map(function(o){\n      var s=o.from===0?(W===null?'':'\u4eca\u53d7\u3051\u3089\u308c\u307e\u3059'):st(o.from,o.to);\n      return '<div class=\"opt'+(s==='\u4eca\u53d7\u3051\u3089\u308c\u307e\u3059'?' now':'')+'\"><span class=\"t\">'+o.t+'<\/span>'+(s?'<span class=\"tag\">'+s+'<\/span>':'')+'<p>'+o.d+'<\/p><\/div>';\n    }).join('');\n\n    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});\n})();\n<\/script>\n\n","protected":false},"excerpt":{"rendered":"\u304a\u6bcd\u3055\u3093\u306e\u5e74\u9f62\u30fb\u65e2\u5f80\u6b74\u30fb\u6d41\u7523\u6b74\u30fb\u598a\u5a20\u9031\u6570\u30fb\u30a8\u30b3\u30fc\u30fb\u30af\u30a2\u30c8\u30ed\u691c\u67fb\u306e\u7d50\u679c\u304b\u3089\u3001\u8d64\u3061\u3083\u3093\u304c\u30c0\u30a6\u30f3\u75c7\uff0821\u30c8\u30ea\u30bd\u30df\u30fc\uff09\u3067\u751f\u307e\u308c\u308b\u78ba\u7387\u306e\u76ee\u5b89\u3092\u8a08\u7b97\u3057\u3001\u4eca\u53d7\u3051\u3089\u308c\u308b\u691c\u67fb\u3092\u3054\u6848\u5185\u3057\u307e\u3059\u3002","protected":false},"author":59,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page_wide.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-137750","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/pages\/137750","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/comments?post=137750"}],"version-history":[{"count":2,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/pages\/137750\/revisions"}],"predecessor-version":[{"id":137764,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/pages\/137750\/revisions\/137764"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=137750"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}