{"id":51771,"date":"2023-02-22T14:21:55","date_gmt":"2023-02-22T05:21:55","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/?page_id=51771"},"modified":"2025-07-23T10:24:11","modified_gmt":"2025-07-23T01:24:11","slug":"unavailable-judgment","status":"publish","type":"page","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/unavailable-judgment\/","title":{"rendered":"\u5224\u5b9a\u4e0d\u80fd\u3068\u51fa\u308b\u7406\u7531"},"content":{"rendered":"\n<section class=\"section\">\n<h2>\u300c\u691c\u67fb\u4e0d\u80fd\u300d\u306b\u306a\u308b\u53ef\u80fd\u6027\u306f\u4f4e\u3044<\/h2>\n<p>\u5f53\u9662\u3067\u306f\u300c\u691c\u67fb\u4e0d\u80fd\u300d\u306b\u306a\u308b\u53ef\u80fd\u6027\u306f\u6975\u3081\u3066\u4f4e\u3044\u3067\u3059\u3002<\/p>\n<p>\u80ce\u5150\u7531\u6765cell-free(cfDNA)\u306e\u6bd4\u7387(Fetal Fraction:FF)\u306e\u4f4e\u5024\u306b\u3088\u308b\u691c\u67fb\u4e0d\u80fd\u306f\u901a\u5e381\uff5e8%\u306e\u983b\u5ea6\u3068\u8a00\u308f\u308c\u3066\u304a\u308a\u3001\u5f53\u9662\u3067\u518d\u691c\u67fb\u3057\u305f\u5834\u5408\u306b\u306f85%\u4ee5\u4e0a\u3067\u691c\u67fb\u304c\u6210\u529f\u3057\u3066\u3044\u307e\u3059\u3002\u203b1<\/p>\n<p>\u691c\u67fb\u306b\u304a\u3051\u308b\u6280\u8853\u7684\u306a\u554f\u984c\u3092\u5341\u5206\u306b\u691c\u8a3c\u3057\u305f\u4e0a\u3067\u518d\u63a1\u8840\u3092\u884c\u3044\u3001\u3055\u3089\u306b\u691c\u4f53\u306e\u54c1\u8cea\u306b\u7531\u6765\u3059\u308b\u53ef\u80fd\u6027\u3092\u6392\u9664\u3057\u3066\u7cbe\u67fb\u3057\u306a\u304a\u3057\u307e\u3059\u3002\u540c\u6642\u306b\u598a\u5a20\u9031\u6570\u3082\u9032\u3080\u305f\u3081FF\u306e\u5897\u52a0\u3082\u898b\u8fbc\u307e\u308c\u307e\u3059\u3002<\/p>\n    <p>\u305d\u306e\u305f\u3081\u5f53\u9662\u3067\u306f\u691c\u67fb\u4e0d\u80fd\u3068\u306a\u308b\u5834\u5408\u306e\u591a\u304f\u306f\u691c\u4f53\u306b\u7531\u6765\u3059\u308b\u751f\u7269\u5b66\u7684\u306a\u7406\u7531\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u975e\u5e38\u306b\u7a00\u3067\u3059\u3002<\/p>\n  <h2>\u300c\u691c\u67fb\u4e0d\u80fd\u300d\u3068\u306a\u308b\u7406\u7531\u306fFF\u4f4e\u5024<\/h2>\n  <p>\u3053\u308c\u307e\u3067\u306b\u691c\u67fb\u4e0d\u80fd\u3068\u306a\u3063\u305f\u7406\u7531\u306e\u5927\u90e8\u5206\u306f\u3001\u518d\u691c\u67fb\u306b\u304a\u3044\u3066\u3082\u540c\u69d8\u306bFF\u304c\u57fa\u6e96\u5024\u3092\u4e0b\u56de\u3063\u305f\u305f\u3081\u3067\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001FF\u306e\u4f4e\u5024\u304c\u539f\u56e0\u3067\u4e00\u5ea6\u76ee\u306e\u691c\u67fb\u7d50\u679c\u304c\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u5834\u5408\u3067\u3082\u300150\uff5e60%\u306e\u5973\u6027\u306f\u518d\u63a1\u8840\u30fb\u518d\u691c\u67fb\u306b\u3088\u3063\u3066\u691c\u67fb\u304c\u6210\u529f\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u203b2,3<br>\n\u53c2\u8003\u307e\u3067\u306b\u3001\u5f53\u9662\u3067\u306e\u30c7\u30fc\u30bf\u3067\u306f4\u9031\u9593\u7a0b\u5ea6\u304a\u3044\u3066\u518d\u63a1\u8840\u3092\u3057\u305f\u5834\u5408\u306b\u306f85\uff05\u4ee5\u4e0a\u3067\u691c\u67fb\u304c\u6210\u529f\u3057\u3066\u304a\u308a\u307e\u3059\u3002\n<\/p>\n  <h3>FF\u4f4e\u5024\u306f\u3069\u306e\u3088\u3046\u306a\u5834\u5408\u306b\u8d77\u3053\u308b\u306e\u304b<\/h3>\n  <p>\n      \u305d\u3082\u305d\u3082FF\u306f\u3069\u306e\u3088\u3046\u306b\u7b97\u51fa\u3057\u3066\u3044\u308b\u304b\u3068\u8a00\u3048\u3070\u3001<br>\n      \u300cFF = \u80ce\u5150cfDNA \/ (\u80ce\u5150cfDNA + \u6bcd\u4f53cfDNA )\u300d<br>\n      \u3053\u306e\u5f0f\u304b\u3089\u5206\u304b\u308b\u3088\u3046\u306b\u6bcd\u4f53cfDNA\u306e\u91cf\u3068\u80ce\u5150cfDNA\u306e\u4e21\u65b9\u304c\u95a2\u4fc2\u3059\u308b\u95a2\u6570\u3067\u3059\u3002<br>\n      <br>\n      \u598a\u5a2010\u9031\uff5e20\u9031\u306e\u9593\u306e\u5e73\u5747FF\u306f10\uff5e15%\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u203b4<br>\n      \u3064\u307e\u308a\u4f55\u3089\u304b\u306e\u7406\u7531\u3067\n      <ul style=\"margin-bottom: 0.5rem;\">\n        <li>\u6bcd\u4f53\u8840\u4e2d\u306e\u80ce\u5150cfDNA\u304c\u5c11\u306a\u3044<\/li>\n        <li>\u6bcd\u4f53\u8840\u4e2d\u306e\u6bcd\u4f53cfDNA\u304c\u591a\u3044<\/li>\n      <\/ul>\n      \u3069\u3061\u3089\u304b\u306e\u7279\u5fb4\u304c\u9855\u8457\u306a\u5834\u5408\uff08\u3082\u3057\u304f\u306f\u4e21\u65b9\u306e\u7279\u5fb4\u304c\u76f8\u4e57\u7684\u306b\u50cd\u304f\u5834\u5408\uff09\u306bFF\u306e\u4f4e\u5024\u304c\u8d77\u3053\u308a\u5f97\u307e\u3059\u3002<br>\n  <\/p>\n  <h3>FF\u4f4e\u5024\u306e\u7406\u7531\u3068\u8d77\u3053\u3063\u305f\u6642\u306e\u691c\u67fb\u30d5\u30ed\u30fc<\/h3>\n  <p>\n      \u305d\u308c\u305e\u308c\u306e\u7406\u7531\u306f\u591a\u5c90\u306b\u6e21\u308a\u307e\u3059\u304c\u3001\u4ee5\u4e0b\u306b\u3053\u308c\u307e\u3067\u306b\u77e5\u898b\u306e\u5f97\u3089\u308c\u3066\u3044\u308b\u4e3b\u306a\u7406\u7531\u3092\u307e\u3068\u3081\u307e\u3059\u3002<br>\n      \uff08\u8a18\u4e8b\u4f5c\u6210\u6642\u70b9\u3067\u5b66\u8853\u7684\u306a\u6839\u62e0\u304c\u8ff0\u3079\u3089\u308c\u3066\u3044\u308b\u3082\u306e\u306b\u9650\u5b9a\u3057\u307e\u3059\u3002\uff09<br>\n      \u3053\u308c\u306fFF\u4f4e\u5024\u304c\u691c\u51fa\u3055\u308c\u305f\u969b\u3001\u5b9f\u969b\u306b\u691c\u67fb\u6a5f\u95a2\u304c\u305f\u3069\u308b\u30d5\u30ed\u30fc\u3067\u3082\u3042\u308a\u307e\u3059\u3002\n  <\/p>\n<div class=\"cyprus_cta\">\n<img decoding=\"async\" src=\"\/nipt\/wp-content\/uploads\/2023\/02\/cyprus-cta_top.png\" alt=\"\u5fae\u5c0f\u6b20\u5931\u30d7\u30e9\u30f3cta\u30dc\u30bf\u30f3\">\n<a href=\"\/nipt\/plan\/n-guard\/\"><img decoding=\"async\" src=\"\/nipt\/wp-content\/uploads\/2023\/02\/cyprus-cta_middle.png\" alt=\"\u5fae\u5c0f\u6b20\u5931\u30d7\u30e9\u30f3\u4e00\u89a7\"><\/a>\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/?wp\"><img decoding=\"async\" src=\"\/nipt\/wp-content\/uploads\/2023\/02\/cyprus-cta_bottom.png\" alt=\"\u51fa\u751f\u524d\u8a3a\u65ad\u4e88\u7d04\u30dc\u30bf\u30f3\"><\/a>\n<\/div>\n\n<style>\n.cyprus_cta{\nmax-width: 500px !important;\nwidth: 100%;\nmargin: 0 auto;\n}\n.cyprus_cta a{\ndisplay: block;\n}\n.cyprus_cta a img:not(first-child){\nmargin-top: -8px;\n}\n<\/style>\n  <h4>\u6280\u8853\u7684\u306a\u554f\u984c\u306e\u53ef\u80fd\u6027\u3092\u6392\u9664<\/h4>\n  <p>\n      \u307e\u305a\u3001\u691c\u67fb\u4e2d\u306b\u8d77\u304d\u305f\u6280\u8853\u7684\u306a\u554f\u984c\u306e\u53ef\u80fd\u6027\u3092\u6392\u9664\u3057\u307e\u3059\u3002<br>\n      \u3053\u308c\u306f\u5bfe\u8c61\u306e\u30b7\u30fc\u30b1\u30f3\u30b9\u30c7\u30fc\u30bf\u5168\u4f53\u306b\u554f\u984c\u304c\u306a\u3044\u3053\u3068\uff08\u901a\u5e3845\u304b\u308995\u4ef6\u306e\u30b7\u30fc\u30b1\u30f3\u30b9\u304c\u540c\u6642\u306b\uff11\u56de\u306e\u691c\u67fb\u3067\u884c\u308f\u308c\u307e\u3059\uff09\u3001\u3088\u308a\u8a73\u7d30\u306a\u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\u30c7\u30fc\u30bf\u3092\u500b\u5225\u306e\u691c\u4f53\u306b\u5bfe\u3057\u3066\u89e3\u6790\u3057\u306a\u304a\u3057\u3066\u554f\u984c\u304c\u306a\u3044\u3053\u3068\uff08\u7d50\u679c\u3092\u51fa\u3059\u305f\u3081\u3060\u3051\u3067\u3042\u308c\u3070\u5fc5\u8981\u306e\u306a\u3044\u54c1\u8cea\u7ba1\u7406\u9805\u76ee\u307e\u3067\u691c\u8a3c\u3057\u307e\u3059\uff09\u304b\u3089\u6570\u5024\u7684\u306b\u7acb\u8a3c\u3067\u304d\u307e\u3059\u3002\n      \u591a\u304f\u304c\u81ea\u52d5\u5316\u3055\u308c\u305f\u691c\u67fb\u5de5\u7a0b\u3092\u305f\u3069\u308a\u3001\u6280\u8853\u306b\u554f\u984c\u304c\u3042\u308c\u3070\u3059\u3050\u306b\u54c1\u8cea\u7ba1\u7406\u5de5\u7a0b\u3067\u5177\u4f53\u7684\u306b\u6570\u5024\u30c7\u30fc\u30bf\u3068\u3057\u3066\u660e\u3089\u304b\u306b\u306a\u308b\u6628\u4eca\u3001\u6280\u8853\u7684\u306a\u554f\u984c\u306f\u691c\u67fb\u6bb5\u968e\u3067\u6392\u9664\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u610f\u5916\u306b\u3082\u5c11\u306a\u3044\u3082\u306e\u3067\u3059\u3002<br>\n  <\/p>\n  <h4>\u691c\u4f53\u306e\u54c1\u8cea\u306b\u3088\u308b\u53ef\u80fd\u6027\u306e\u6392\u9664<\/h4>\n  <p>\n      \u6b21\u306b\u3001\u691c\u4f53\u7531\u6765\u306e\u539f\u56e0\u306e\u3046\u3061\u8f38\u9001\u3084\u4fdd\u5b58\u306a\u3069\u3001\u691c\u67fb\u306b\u8010\u3048\u3046\u308b\u691c\u4f53\u3067\u306a\u304b\u3063\u305f\u53ef\u80fd\u6027\u3092\u6392\u9664\u3057\u307e\u3059\u3002<br>\n      \u3053\u308c\u304c\u518d\u63a1\u8840\u3092\u304a\u9858\u3044\u3055\u305b\u3066\u3044\u305f\u3060\u304f\u7406\u7531\u306e\u3046\u3061\u5927\u304d\u306a\u3082\u306e\u306e1\u3064\u3067\u3059\u3002\u63a1\u8840\u304b\u3089\u3084\u308a\u76f4\u3059\u3053\u3068\u3067\u3001\u80ce\u5150\u306ecfDNA\u304c\u5897\u3048\u308b\u3053\u3068\u306f\u5f8c\u8ff0\u3057\u307e\u3059\u304c\u3001\u540c\u6642\u306b1\u56de\u76ee\u306e\u691c\u67fb\u6642\u3001\u8f38\u9001\u3084\u4fdd\u5b58\u306a\u3069\u691c\u4f53\u306e\u54c1\u8cea\u306b\u4f55\u3089\u304b\u306e\u30a4\u30ec\u30ae\u30e5\u30e9\u30fc\u304c\u751f\u3058\u3066\u3044\u305f\u53ef\u80fd\u6027\u3092\u7cbe\u67fb\u3057\u306a\u304a\u3057\u307e\u3059\u3002<br>\n      <br>\n      \u3053\u3053\u307e\u3067\u3092\u6d88\u53bb\u6cd5\u3067\u9664\u5916\u3059\u308b\u307e\u3067\u306f\u591a\u304f\u306e\u5834\u5408\u3001\u691c\u67fb\u6a5f\u95a2\u3067\u4fdd\u8a3c\u53ef\u80fd\u3067\u3059\u304c\u3001\u7d9a\u3051\u3066\u8ff0\u3079\u308b\u300c\u691c\u4f53\u306b\u7531\u6765\u3059\u308b\u751f\u7269\u5b66\u7684\u306a\u7406\u7531\u300d\u306b\u95a2\u3057\u3066\u306f\u3001\u53ef\u80fd\u6027\u3092\u793a\u5506\u3059\u308b\u3053\u3068\u3057\u304b\u3067\u304d\u305a\u539f\u56e0\u3092\u7a81\u304d\u6b62\u3081\u308b\u3053\u3068\u304c\u73fe\u5b9f\u7684\u306b\u4e0d\u53ef\u80fd\u3067\u3059\u3002<br>\n      \uff08\u305d\u3057\u3066\u591a\u304f\u306e\u5834\u5408\u3001\u3042\u307e\u308a\u610f\u5473\u306e\u3042\u308b\u8ffd\u53ca\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\uff09\n  <\/p>\n  <h4>\u691c\u4f53\u306b\u7531\u6765\u3059\u308b\u751f\u7269\u5b66\u7684\u306a\u7406\u7531<\/h4>\n      <ul>\n          <li>\u598a\u5a20\u9031\u6570\u306e\u4e0d\u8db3\uff08\u9031\u6570\u304c\u9032\u3080\u307b\u3069FF\u5897\u52a0\uff09\u203b5<\/li>\n          <li>\u982d\u6bbf\u9577 (CRL) \u306e\u5024\u304c\u5c0f\u3055\u3044\uff08\u5927\u304d\u304f\u306a\u308b\u307b\u3069FF\u5897\u52a0\uff09\u203b6<\/li>\n          <li><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u73fe\u8c61\uff08FF\u6e1b\u5c11\uff09\u203b7<\/li>\n          <li>\u80ce\u5150\u304c\u7570\u6570\u6027\u3092\u6709\u3057\u3066\u3044\u308b (FF\u3078\u306e\u5f71\u97ff\u306f\u69d8\u3005)\u203b8,9,10,11<\/li>\n          <li>\u4e09\u500d\u4f53\uff08FF\u6e1b\u5c11\uff09\u203b12<\/li>\n          <li>\u591a\u80ce\u598a\u5a20\uff08\u7dcfFF\u5897\u52a0\u3001\u305f\u3060\u3057\u80ce\u5150\u3054\u3068\u3067\u898b\u308b\u3068FF\u6e1b\u5c11\uff09\u203b13,14<\/li>\n      <\/ul>\n      <p style=\"margin-bottom: 0;\">(\u4ee5\u4e0b\u3001\u6bcd\u4f53\u306b\u7531\u6765\u3059\u308b\u751f\u7269\u5b66\u7684\u306a\u7406\u7531)<\/p>\n      <ul>\n          <li>\u6bcd\u4f53\u306eBMI\u306e\u5024\u304c\u9ad8\u3044\uff08\u9ad8\u3044\u7a0bFF\u6e1b\u5c11\uff09\u203b8,5,15<\/li>\n          <li>\u6bcd\u4f53\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\uff08\u75c5\u614b\u306e\u6d3b\u6027\u5ea6\u304c\u9ad8\u3044\u307b\u3069FF\u6e1b\u5c11\uff09\u203b16,17,18<\/li>\n          <li>\u4f4e\u5206\u5b50\u91cf\u30d8\u30d1\u30ea\u30f3\u306e\u670d\u85ac\uff08FF\u6e1b\u5c11\u306e\u53ef\u80fd\u6027\u3042\u308a\uff09\u203b19,20,21,22<\/li>\n          <li>\u8840\u6e05\u4e2d\u306e\u598a\u5a20\u95a2\u9023\u8840\u6f3f\u30bf\u30f3\u30d1\u30af\u8ceaPaPP-A\uff08FF\u5897\u52a0\uff09\u203b6,23<\/li>\n          <li>\u8840\u6e05\u4e2d\u306e\u904a\u96e2\u03b2-HCG\uff08FF\u5897\u52a0\uff09\u203b6,24<\/li>\n          <li>\u6c11\u65cf\u9593\u5dee (FF\u3078\u306e\u5f71\u97ff\u306f\u69d8\u3005)\u203b6,14,25<\/li>\n          <li>\u751f\u6b96\u88dc\u52a9\u533b\u7642ART\u306b\u3088\u308b\u53d7\u80ce\uff08FF\u6e1b\u5c11\uff09\u203b24<\/li>\n          <li>\u7d4c\u7523\u56de\u6570\uff08FF\u6e1b\u5c11\uff09\u203b14, 25<\/li>\n          <li>\u6bcd\u4f53\u306e\u5e74\u9f62\uff08FF\u6e1b\u5c11\uff09\u203b14, 25<\/li>\n      <\/ul>\n  <p>\n      \u3053\u306e\u751f\u7269\u5b66\u7684\u306a\u7406\u7531\u3092\u9650\u5b9a\u3059\u308b\u3053\u3068\u306f\u3001\u524d\u8ff0\u306e\u901a\u308a\u6b8b\u5ff5\u306a\u304c\u3089\u307b\u307c\u4e0d\u53ef\u80fd\u3067\u3059\u3002<br>\n      \u4e00\u3064\u4e00\u3064\u306e\u53ef\u80fd\u6027\u306b\u5bfe\u3057\u3001\u3057\u3089\u307f\u3064\u3076\u3057\u306b\u5c02\u9580\u7684\u306a\u691c\u8a3c\u3092\u884c\u3046\u305f\u3081\u306b\u306f\u81a8\u5927\u306a\u6642\u9593\u3084\u8cbb\u7528\u304c\u304b\u304b\u308a\u3001\u73fe\u5b9f\u7684\u3067\u306f\u306a\u304f\u3001\u4eee\u306b\u539f\u56e0\u304c\u7a81\u304d\u6b62\u3081\u3089\u308c\u305f\u3068\u3057\u3066\u3082\u5206\u304b\u308b\u3053\u3068\u306f\u3001\u591a\u304f\u306e\u5834\u5408NIPT\u691c\u67fb\u304c\u5bfe\u8c61\u306e\u598a\u5a66\u69d8\u306b\u3068\u3063\u3066\u4e0d\u5411\u304d\u3067\u3042\u308b\u3068\u3044\u3046\u4e8b\u3060\u3051\u3060\u304b\u3089\u3067\u3059\u3002\n  <\/p>\n<div class=\"cyprus_cta\">\n<img decoding=\"async\" src=\"\/nipt\/wp-content\/uploads\/2023\/02\/cyprus-cta_top.png\" alt=\"\u5fae\u5c0f\u6b20\u5931\u30d7\u30e9\u30f3cta\u30dc\u30bf\u30f3\">\n<a href=\"\/nipt\/plan\/n-guard\/\"><img decoding=\"async\" src=\"\/nipt\/wp-content\/uploads\/2023\/02\/cyprus-cta_middle.png\" alt=\"\u5fae\u5c0f\u6b20\u5931\u30d7\u30e9\u30f3\u4e00\u89a7\"><\/a>\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/?wp\"><img decoding=\"async\" src=\"\/nipt\/wp-content\/uploads\/2023\/02\/cyprus-cta_bottom.png\" alt=\"\u51fa\u751f\u524d\u8a3a\u65ad\u4e88\u7d04\u30dc\u30bf\u30f3\"><\/a>\n<\/div>\n\n<style>\n.cyprus_cta{\nmax-width: 500px !important;\nwidth: 100%;\nmargin: 0 auto;\n}\n.cyprus_cta a{\ndisplay: block;\n}\n.cyprus_cta a img:not(first-child){\nmargin-top: -8px;\n}\n<\/style>\n  <p class=\"sankou\">\u3010\u53c2\u8003\u6587\u732e\u3011<\/p>\n  <ul class=\"number\">\n      <li>Yaron Y. The implications of non-invasive prenatal testing failures: a review of an under-discussed phenomenon. Prenat Diagn. 2016;36:391-396.<\/li>\n      <li>Kinnings SL, Geis JA, Almasri E, et al. Factors affecting levels of circulating cell-free fetal DNA in maternal plasma and their implications for noninvasive prenatal testing. Prenat Diagn. 2015;35:816-822.<\/li>\n      <li>Hui L, Teoh M, da Silva Costa F, et al. Clinical implementation of cell free DNA based aneuploidy screening: perspectives from a national audit. Ultrasound Obstet Gynecol. 2015;45:10-15.<\/li>\n      <li>Ashoor G, Syngelaki A, Poon LC, Rezende JC, Nicolaides KH. Fetal fraction in maternal plasma cell-free DNA at 11-13 weeks&#8217; gestation: relation to maternal and fetal characteristics. Ultrasound Obstet Gynecol. 2013;41:26-32.<\/li>\n      <li>Kinnings SL, Geis JA, Almasri E, et al. Factors affecting levels of circulating cell-free fetal DNA in maternal plasma and their implications for noninvasive prenatal testing. Prenat Diagn. 2015;35:816-822.<\/li>\n      <li>Ashoor G, Syngelaki A, Poon LC, Rezende JC, Nicolaides KH. Fetal fraction in maternal plasma cell-free DNA at 11-13 weeks&#8217; gestation: relation to maternal and fetal characteristics. Ultrasound Obstet Gynecol. 2013;41:26-32.<\/li>\n      <li>Brison N, Neofytou M, Dehaspe L, et al. Predicting fetoplacental chromosomal mosaicism during noninvasive prenatal testing. Prenat Diagn. 2018;38(4):258-266. https:\/\/doi.org\/10.1002\/pd.5223.<\/li>\n      <li>Ashoor G, Syngelaki A, Poon LC, Rezende JC, Nicolaides KH. Fetal fraction in maternal plasma cell-free DNA at 11-13 weeks&#8217; gestation: relation to maternal and fetal characteristics. Ultrasound Obstet Gynecol. 2013;41:26-32.<\/li>\n      <li>Kinnings SL, Geis JA, Almasri E, et al. Factors affecting levels of circulating cell-free fetal DNA in maternal plasma and their implications for noninvasive prenatal testing. Prenat Diagn. 2015;35:816-822.<\/li>\n      <li>Palomaki GE, Kloza EM, Lambert-Messerlian GM, et al. Circulating cell free DNA testing: are some test failures informative? Prenat Diagn. 2015;35:289-293.<\/li>\n      <li>Rava RP, Srinivasan A, Sehnert AJ, Bianchi DW. Circulating fetal cell free DNA fractions differ in autosomal aneuploidies and monosomy X. Clin Chem. 2014;60:243-250.<\/li>\n      <li>Nicolaides KH, Syngelaki A, del Mar Gil M, Quezada MS, Zinevich Y. Prenatal detection of fetal triploidy from cell-free DNA testing in maternal blood. Fetal Diagn Ther. 2014;35(3):212-217.<\/li>\n      <li>Hedriana H, Martin K, Saltzman D, Billings P, Demko Z, Benn P. Cell Free DNA fetal fraction in twin gestations in single nucleotide polymorphism-based non-invasive prenatal screening. Prenat Diagn. 2019. https:\/\/doi.org\/10.1002\/pd.5609 [Epub ahead of print].<\/li>\n      <li>Galeva S, Gil MM, Konstantinidou L, Akolekar R, Nicolaides KH. First trimester screening for trisomies by cfDNA testing of maternal blood in singleton and twin pregnancies: factors affecting test failure. Ultrasound Obstet Gynecol. 2019;53:804-809.<\/li>\n      <li>Kinnings SL, Geis JA, Almasri E, et al. Factors affecting levels of circulating cell-free fetal DNA in maternal plasma and their implications for noninvasive prenatal testing. Prenat Diagn. 2015;35:816-822.<\/li>\n      <li>Chan RWY, Jiang P, Peng Z, et al. Plasma DNA aberrations in systemic lupus erythematosus revealed by genomic and methylomic sequencing. Proc Natl Acad Sci U S A. 2015;111:E5302-E5311.<\/li>\n      <li>Hui L, Bethune M, Weeks A, Kelley J, Hayes L. Repeated failed non invasive prenatal testing owing to low cell-free fetal DNA fraction and increased variance in a woman with severe autoimmune disease. Ultrasound Obstet Gynecol. 2014;44:242-243.<\/li>\n      <li>Hui CY, Tan WC, Tan EL, Tan LK. Repeated failed non-invasive prenatal testing in a woman with immune thrombocytopenia and antiphospholipid syndrome: lessons learnt. BMJ Case Rep. 2016;2016. https:\/\/doi.org\/10.1136\/bcr-2016-216593.<\/li>\n      <li>Burns W, Koelper N, Barberio A, et al. The association between anti coagulation therapy, maternal characteristics, and a failed cfDNA test due to a low fetal fraction. Prenat Diagn. 2017;37:1125-1129.<\/li>\n      <li>Ma G, Wu W, Lee M, Lin Y, Chen M. Low-molecular-weight heparin associated with reduced fetal fraction and subsequent false-negative cell-free DNA test result for trisomy 21.Ultrasound Obstet Gynecol. 2018;51:276-277.<\/li>\n      <li>Gromminger S, Erkan S, Schock U, et al. The influence of low molecular weight heparin medication on plasma DNA in pregnant women.Prenat Diagn. 2015;35:1155-1157.<\/li>\n      <li>Dabi Y, Guterman S, Jani JC, et al. Autoimmune disorders but not heparin are associated with cell-free fetal DNA test failure. J Transl Med. 2018;16(1):335. https:\/\/doi.org\/10.1186\/s12967-018-1705-2.<\/li>\n      <li>Scott FP, Menezes M, Palma-Dias R, et al. Factors affecting cell-free DNA fetal fraction and the consequences for test accuracy. J Matern Fetal Neonatal Med. 2018;31(14):1865-1872.<\/li>\n      <li>Lee TJ, Rolnik DL, Menezes MA, McLennan AC, da Silva Costa F. Cell-free fetal DNA testing in singleton IVF conceptions. Hum Reprod. 2018;33(4):572-578.<\/li>\n      <li>Rolnik DL, Da Silva Costa F, Lee TJ, Schmid M, McLennan AC. Association between fetal fraction on cell-free DNA testing and first trimester markers for pre-eclampsia. Ultrasound Obstet Gynecol. 2019. https:\/\/doi.org\/10.1002\/uog.18993.<\/li>\n  <\/ul>\n<div class=\"cyprus_cta\">\n<img decoding=\"async\" src=\"\/nipt\/wp-content\/uploads\/2023\/02\/cyprus-cta_top.png\" alt=\"\u5fae\u5c0f\u6b20\u5931\u30d7\u30e9\u30f3cta\u30dc\u30bf\u30f3\">\n<a href=\"\/nipt\/plan\/n-guard\/\"><img decoding=\"async\" src=\"\/nipt\/wp-content\/uploads\/2023\/02\/cyprus-cta_middle.png\" alt=\"\u5fae\u5c0f\u6b20\u5931\u30d7\u30e9\u30f3\u4e00\u89a7\"><\/a>\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/?wp\"><img decoding=\"async\" src=\"\/nipt\/wp-content\/uploads\/2023\/02\/cyprus-cta_bottom.png\" alt=\"\u51fa\u751f\u524d\u8a3a\u65ad\u4e88\u7d04\u30dc\u30bf\u30f3\"><\/a>\n<\/div>\n\n<style>\n.cyprus_cta{\nmax-width: 500px !important;\nwidth: 100%;\nmargin: 0 auto;\n}\n.cyprus_cta a{\ndisplay: block;\n}\n.cyprus_cta a img:not(first-child){\nmargin-top: -8px;\n}\n<\/style>\n<\/section>\n\n\n\n<style>\n  #article {\n    max-width: 1100px;\n    width: 100%;\n    margin: 0 auto;\n    padding: 0 20px;\n    box-sizing: border-box;\n  }\n  a {\n    text-decoration: underline;\n  }\n  .section ul {\n    list-style-type: disc;\n    padding-left: 20px;\n  }\n  .section ul.number {\n    list-style-type: decimal;\n  }\n  .sankou{\n    font-weight: bold;\n    margin: 2rem 0 0 !important;\n  }\n<\/style>\n\n\n<div class=\"newcta\">\r\n <a href=\"https:\/\/mypage-nipt-reservation.hiro-clinic.or.jp\/registration\">\r\n  <p class=\"jisseki mincho\">NIPT\u691c\u67fb\u5b9f\u7e3e<span class=\"big\">75,000<span>\u4ef6\u4ee5\u4e0a<\/span><\/span><\/p>\r\n  <p class=\"res-btn\">\u7a7a\u304d\u72b6\u6cc1\u3092\u78ba\u8a8d\u3057\u3066\u4e88\u7d04\u3059\u308b<\/p>\r\n <\/a>\r\n<\/div>\r\n<style>\r\n.newcta{\r\n  margin:1rem auto 2rem;\r\n}\r\n.newcta a{\r\n  width:100%;\r\n  max-width:500px;\r\n  margin:0 auto;\r\n  display:block;\r\n  text-decoration:none;\r\n  text-align:center;\r\n}\r\n.newcta p{\r\n  margin:0 auto;\r\n}\r\n.newcta .jisseki{\r\n  margin:0 auto;\r\n  position:relative;\r\n  font-size:clamp(1rem, 0.909rem + 0.45vw, 1.25rem);\r\n  background: linear-gradient(to bottom, #b68d3c 0%, #e2b95f 35%, #b68d3c);\r\n  -webkit-background-clip: text;\r\n  color: rgba(0,0,0,0);\r\n  font-weight:bold;\r\n  display:inline-flex;\r\n  flex-wrap:wrap;\r\n  align-items:center;\r\n  justify-content:center;\r\n  gap:.5rem;\r\n  padding-bottom:1rem;\r\n}\r\n.newcta .jisseki span{\r\n  font-size:2rem;\r\n}\r\n.newcta .jisseki span span{\r\n  font-size:clamp(1rem, 0.909rem + 0.45vw, 1.25rem);\r\n}\r\n.newcta .res-btn{\r\n  display:inline-block;\r\n  background:#f0a3b8;\r\n  padding:1.5rem 2rem;\r\n  text-align:center;\r\n  border-radius:1rem;\r\n  box-shadow:0 .5rem .5rem #f0a3b866;\r\n  color:#fff;\r\n  font-size:1.2rem;\r\n  font-weight:bold;\r\n  letter-spacing:.2rem;\r\n  min-width:320px;\r\n}\r\n@media screen and (max-width:500px){\r\n  .newcta .jisseki .big{\r\n    width:100%;\r\n  }\r\n  .newcta .res-btn{\r\n    padding:1.5rem 0;\r\n  }\r\n}\r\n<\/style>\r\n<div class=\"old-cta\">\r\n<div class=\"container\" style=\"padding:10px\">\r\n<div class=\"nipt-bnr mincho\">\r\n<a href=\"https:\/\/mypage-nipt-reservation.hiro-clinic.or.jp\/registration\">\r\n<p class=\"jisseki font-s gothic\">NIPT\u691c\u67fb\u5b9f\u7e3e<\/p>\r\n<p class=\"total font-m\"><span class=\"gold font-l\">68,000<\/span>\u4ef6<\/p>\r\n<p class=\"res font-s gothic\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089\u25b6\ufe0e\u25b6\ufe0e\u25b6\ufe0e<\/p>\r\n<\/a>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div class=\"content-center\" style=\"max-width:1200px;margin:0 auto;width:90%\">\r\n <div class=\"image-text-block\">\r\n<a href=\"\/nipt\/20th-anniversary\/\" style=\"max-width:825px;margin:0.5rem auto\"><img decoding=\"async\" src=\"\/nipt\/wp-content\/uploads\/2026\/05\/forplan_btn-0525.webp\" style=\"width:100%\"><\/a>\r\n <\/div>\r\n<\/div>\r\n<style>\r\n.old-cta{\r\n  display:none;\r\n}\r\n.nipt-bnr{\r\n  display:flex;\r\n  justify-content:center;\r\n  align-items:center;\r\n  width:calc(100% - 3rem);\r\n  min-width:350px;\r\n  max-width:480px;\r\n  aspect-ratio:11 \/ 5;\r\n  position:relative;\r\n  margin:1rem auto;\r\n  background-image:linear-gradient(to bottom,#63513c,#63513c,#feef7b,#63513c,#63513c);\r\n  border-radius:8px;\r\n  box-shadow:6px 6px 6px #999;\r\n}\r\n.nipt-bnr .gold{\r\n  background:linear-gradient(to bottom,#d1ac60,#e8ca74 50%,#d29e30,#ac7726);\r\n  -webkit-background-clip: text;\r\n  -webkit-text-fill-color: transparent;\r\n  font-weight:bold;\r\n}\r\n.cta-btn-nipt-reservation-wimg{\r\n  text-decoration:none;\r\n  border-bottom:initial;\r\n}\r\n.label-link {\r\n  align-items: center;\r\n  text-decoration: none;\r\n  gap: 8px;\r\n}\r\n.image-text-block {\r\n  text-align: center;\r\n}\r\n.tittle_price{\r\n font-weight:900;\r\n font-size:2rem;\r\n color:#e54c84;\r\n text-align:center;\r\n border-bottom:none;\r\n margin-bottom:-10px;\r\n}\r\n.box_11 {\r\n  width: 12px;\r\n  height: 12px;\r\n  background-color: #e54c84;\r\n  border-radius: 2px;\r\n  flex-shrink: 0;\r\n}\r\n.center-container {\r\n  text-align: center;\r\n}\r\n.label-box{\r\ndisplay:block;\r\nfont-size:1.3rem !important;\r\nfont-weight:900;\r\ncolor:#e54c84;\r\ntext-align:right;\r\n}\r\n<\/style>\n","protected":false},"excerpt":{"rendered":"\u300c\u691c\u67fb\u4e0d\u80fd\u300d\u306b\u306a\u308b\u53ef\u80fd\u6027\u306f\u4f4e\u3044 \u5f53\u9662\u3067\u306f&#8230;\n <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/unavailable-judgment\/\">\u7d9a\u304d\u3092\u8aad\u3080<\/a>","protected":false},"author":13,"featured_media":0,"parent":0,"menu_order":168,"comment_status":"closed","ping_status":"closed","template":"page_wide.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-51771","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/pages\/51771","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/comments?post=51771"}],"version-history":[{"count":11,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/pages\/51771\/revisions"}],"predecessor-version":[{"id":107223,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/pages\/51771\/revisions\/107223"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=51771"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}