{"id":72959,"date":"2023-02-22T14:21:55","date_gmt":"2023-02-22T05:21:55","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/unavailable-judgment\/"},"modified":"2024-02-29T15:56:22","modified_gmt":"2024-02-29T06:56:22","slug":"unavailable-judgment","status":"publish","type":"page","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/unavailable-judgment\/?lang=zh-hans","title":{"rendered":"\u65e0\u6cd5\u5224\u5b9a\u7684\u539f\u56e0"},"content":{"rendered":"\n<section class=\"section\">\n<h2>\u4e0d\u592a\u53ef\u80fd\u662f\u300c\u65e0\u6cd5\u68c0\u67e5\u300d<\/h2>\n<p>\u5728\u672c\u9662\uff0c\u51fa\u73b0 \u300c\u65e0\u6cd5\u68c0\u67e5\u300d \u7684\u53ef\u80fd\u6027\u6781\u4f4e\u3002<\/p>\n<p>\u7531\u4e8e\u80ce\u513f\u4ea7\u751f\u7684cell-free (cfDNA) \u6bd4\u7387 (Fetal Fraction:FF) \u8fc7\u4f4e\u800c\u65e0\u6cd5\u8fdb\u884c\u68c0\u67e5\u7684\u60c5\u51b5\u4e00\u822c\u4e3a1~8%,\u800c\u5728\u672c\u533b\u9662\u91cd\u65b0\u68c0\u67e5\u65f6, \u8d85\u8fc785%\u7684\u60c5\u51b5\u4e0b\u53ef\u4ee5\u68c0\u67e5\u6210\u529f\u3002\u203b1<\/p>\n<p>\u5728\u5145\u5206\u786e\u8ba4\u68c0\u67e5\u4e2d\u6280\u672f\u95ee\u9898\u7684\u57fa\u7840\u4e0a\u8fdb\u884c\u91cd\u65b0\u62bd\u8840,\u8fdb\u800c\u6392\u9664\u6837\u672c\u8d28\u91cf\u7684\u53ef\u80fd\u6027,\u5e76\u91cd\u65b0\u8fdb\u884c\u7cbe\u5bc6\u68c0\u67e5\u3002\u968f\u7740\u6000\u5b55\u5468\u6570\u7684\u589e\u52a0,\u9884\u6d4bFF\u4e5f\u4f1a\u968f\u4e4b\u589e\u52a0\u3002<\/p>\n    <p>\u56e0\u6b64,\u5728\u672c\u9662\u65e0\u6cd5\u8fdb\u884c\u68c0\u67e5\u7684\u60c5\u51b5\u5927\u591a\u662f\u6765\u81ea\u68c0\u4f53\u7684\u751f\u7269\u5b66\u539f\u56e0,\u6781\u4e3a\u7f55\u89c1\u3002<\/p>\n  <h2>\u300c\u65e0\u6cd5\u68c0\u67e5\u300d \u7684\u539f\u56e0\u662fFF\u504f\u4f4e<\/h2>\n  <p>\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u5927\u591a\u6570\u65e0\u6cd5\u68c0\u67e5\u7684\u539f\u56e0\u662fFF\u5728\u91cd\u65b0\u68c0\u67e5\u65f6\u4e5f\u4f4e\u4e8e\u6807\u51c6\u503c\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u5373\u4fbf\u56e0FF\u503c\u8fc7\u4f4e\u800c\u65e0\u6cd5\u53d6\u5f97\u9996\u6b21\u68c0\u67e5\u7684\u7ed3\u679c,\u4ecd\u670950%~60%\u7684\u5973\u6027\u8ba4\u4e3a\u901a\u8fc7\u518d\u6b21\u62bd\u8840\u548c\u590d\u67e5\u53ef\u4ee5\u6210\u529f\u3002\u203b2,3<br>\n\u505a\u4e3a\u53c2\u8003,\u672c\u9662\u7684\u6570\u636e\u663e\u793a,\u95f4\u96944\u5468\u5de6\u53f3\u518d\u62bd\u8840\u7684\u60c5\u51b5\u4e0b, \u8d85\u8fc785%\u7684\u68c0\u67e5\u662f\u987a\u5229\u7684\u3002\n<\/p>\n  <h3>FF\u503c\u4f4e\u4f1a\u5728\u4ec0\u4e48\u60c5\u51b5\u4e0b\u53d1\u751f?<\/h3>\n  <p>\n      \u8bf4\u5230\u5982\u4f55\u521d\u6b65\u8ba1\u7b97FF,<br>\n      \u300cFF=\u80ce\u513fcfDNA\/ (\u80ce\u513fcfDNA+\u6bcd\u4f53cfDNA)\u300d<br>\n      \u4ece\u8fd9\u4e2a\u516c\u5f0f\u53ef\u4ee5\u770b\u51fa\u662f\u4e0e\u6bcd\u4f53cfDNA\u7684\u91cf\u548c\u80ce\u513fcfDNA\u4e24\u8005\u76f8\u5173\u7684\u51fd\u6570\u3002<br>\n      <br>\n      \u636e\u8bf4\u6000\u5b5510\u5468~20\u5468\u4e4b\u95f4, FF\u5e73\u5747\u4e3a10~15%\u3002\u203b4<br>\n      \u8fd9\u5c31\u610f\u5473\u7740,\u51fa\u4e8e\u67d0\u79cd\u539f\u56e0\n      <ul style=\"margin-bottom: 0.5rem;\">\n        <li>\u6bcd\u4f53\u8840\u6db2\u4e2d\u7684\u80ce\u513fcfDNA\u8f83\u5c11<\/li>\n        <li>\u6bcd\u4f53\u8840\u6db2\u4e2d\u7684\u6bcd\u4f53cfDNA\u8f83\u591a<\/li>\n      <\/ul>\n      \u82e5\u4efb\u4e00\u7279\u5f81\u6bd4\u8f83\u7a81\u51fa (\u6216\u662f\u4e24\u4e2a\u7279\u5f81\u5171\u540c\u4f5c\u7528) ,\u5219FF\u503c\u53ef\u80fd\u8f83\u4f4e\u3002<br>\n  <\/p>\n  <h3>FF\u503c\u504f\u4f4e\u7684\u539f\u56e0\u53ca\u53d1\u751f\u65f6\u7684\u68c0\u67e5\u6d41\u7a0b<\/h3>\n  <p>\n     \u8fd9\u4e9b\u539f\u56e0\u662f\u591a\u65b9\u9762\u7684,\u4f46\u4ee5\u4e0b\u662f\u8fc4\u4eca\u4e3a\u6b62\u53d1\u73b0\u7684\u4e3b\u8981\u539f\u56e0\u3002<br>\n      \uff08\u4ec5\u9650\u5728\u64b0\u5199\u672c\u6587\u65f6\u63d0\u4f9b\u7684\u5b66\u672f\u89c2\u70b9\u3002\uff09<br>\n      \u5f53\u68c0\u6d4b\u5230FF\u503c\u8f83\u4f4e\u65f6,\u68c0\u67e5\u673a\u6784\u5b9e\u9645\u4e0a\u4e5f\u4f1a\u9075\u5faa\u6b64\u6d41\u7a0b\u3002\n  <\/p>\n<div class=\"cyprus_cta\">\n<img decoding=\"async\" src=\"\/nipt\/wp-content\/uploads\/2023\/02\/cyprus-cta_top.png\" alt=\"\u5fae\u5c0f\u6b20\u5931\u30d7\u30e9\u30f3cta\u30dc\u30bf\u30f3\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/plan\/n-guard\/?lang=zh-hans\"><img decoding=\"async\" src=\"\/nipt\/wp-content\/uploads\/2023\/02\/cyprus-cta_middle.png\" alt=\"\u5fae\u5c0f\u6b20\u5931\u30d7\u30e9\u30f3\u4e00\u89a7\"><\/a>\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/?wp\"><img decoding=\"async\" src=\"\/nipt\/wp-content\/uploads\/2023\/02\/cyprus-cta_bottom.png\" alt=\"\u51fa\u751f\u524d\u8a3a\u65ad\u4e88\u7d04\u30dc\u30bf\u30f3\"><\/a>\n<\/div>\n\n<style>\n.cyprus_cta{\nmax-width: 500px !important;\nwidth: 100%;\nmargin: 0 auto;\n}\n.cyprus_cta a{\ndisplay: block;\n}\n.cyprus_cta a img:not(first-child){\nmargin-top: -8px;\n}\n<\/style>\n  <h4>\u6392\u9664\u6280\u672f\u95ee\u9898\u7684\u53ef\u80fd\u6027<\/h4>\n  <p>\n      \u9996\u5148\uff0c\u6392\u9664\u68c0\u67e5\u4e2d\u53ef\u80fd\u51fa\u73b0\u7684\u6280\u672f\u95ee\u9898\u3002<br>\n      \u8fd9\u80fd\u591f\u4ece\u4ee5\u4e0b\u51e0\u4e2a\u65b9\u9762\u8fdb\u884c\u6570\u5b57\u9a8c\u8bc1,\u4f8b\u5982,\u76ee\u6807\u5e8f\u5217\u6570\u636e\u6574\u4f53\u6ca1\u6709\u5f02\u5e38 (\u901a\u5e38\u5728\u5355\u4e2a\u68c0\u67e5\u4e2d\u540c\u65f6\u8fdb\u884c45\u523095\u4e2a\u5e8f\u5217) ,\u6216\u662f\u5bf9\u5355\u4e2a\u6837\u672c\u91cd\u65b0\u5206\u6790\u66f4\u8be6\u7ec6\u7684\u751f\u7269\u4fe1\u606f\u5b66\u6570\u636e\u4ee5\u786e\u4fdd\u6ca1\u6709\u4efb\u4f55\u95ee\u9898 (\u5982\u679c\u53ea\u662f\u4e3a\u4e86\u5f97\u5230\u7ed3\u679c,\u5219\u68c0\u67e5\u4e0d\u9700\u8981\u7684\u8d28\u91cf\u63a7\u5236\u9879\u76ee) \u3002\n      \u8fd1\u5e74\u6765\uff0c\u5982\u679c\u8bb8\u591a\u4eba\u9075\u5faa\u81ea\u52a8\u5316\u68c0\u67e5\u8fc7\u7a0b,\u4e00\u65e6\u6280\u672f\u51fa\u73b0\u95ee\u9898,\u5c31\u4f1a\u5728\u8d28\u91cf\u63a7\u5236\u8fc7\u7a0b\u4e2d\u660e\u786e\u663e\u793a\u5177\u4f53\u7684\u6570\u636e\u3002\u4ee4\u4eba\u60ca\u8bb6\u7684\u662f,\u6280\u672f\u95ee\u9898\u5728\u68c0\u67e5\u9636\u6bb5\u88ab\u6392\u9664\u5728\u5916\uff0c\u6240\u4ee5\u5f88\u5c11\u53d1\u751f\u3002<br>\n  <\/p>\n  <h4>\u901a\u8fc7\u6837\u672c\u8d28\u91cf\u6392\u9664\u53ef\u80fd\u6027<\/h4>\n  <p>\n      \u5176\u6b21,\u5c06\u6392\u9664\u6765\u6e90\u4e8e\u6837\u672c\u7684\u539f\u56e0\u4e2d,\u8fd0\u8f93\u548c\u4fdd\u5b58\u7b49,\u53ef\u80fd\u4e0d\u662f\u7ecf\u5f97\u4f4f\u68c0\u67e5\u7684\u6837\u672c\u3002<br>\n     \u8fd9\u5c31\u662f\u8ba9\u6211\u4eec\u518d\u6b21\u62bd\u8840\u7684\u539f\u56e0\u4e4b\u4e00\u3002\u901a\u8fc7\u91cd\u65b0\u62bd\u8840,\u80ce\u513f\u7684cfDNA\u589e\u52a0\u7684\u60c5\u51b5\u4f1a\u5728\u540e\u9762\u53d9\u8ff0,\u4f46\u540c\u65f6\u5728\u8fdb\u884c\u7b2c1\u6b21\u68c0\u67e5\u65f6,\u4f1a\u4ed4\u7ec6\u786e\u8ba4\u5728\u8fd0\u8f93\u548c\u4fdd\u5b58\u7b49\u68c0\u4f53\u7684\u8d28\u91cf\u4e0a\u4ea7\u751f\u67d0\u79cd\u5f02\u5e38\u7684\u53ef\u80fd\u6027\u3002<br>\n      <br>\n      \u5728\u591a\u6570\u60c5\u51b5\u4e0b,\u76f4\u81f3\u76ee\u524d\u4e3a\u6b62\u7528\u6d88\u9664\u6cd5\u5c06\u5176\u6392\u9664\u5728\u5916,\u68c0\u67e5\u673a\u5173\u662f\u53ef\u4ee5\u62c5\u4fdd\u7684,\u4e0d\u8fc7\u5173\u4e8e\u63a5\u4e0b\u6765\u6240\u8bf4\u7684 \u300c\u6837\u672c\u6765\u6e90\u7684\u751f\u7269\u5b66\u4e0a\u539f\u56e0\u300d ,\u53ea\u80fd\u8868\u660e\u53ef\u80fd\u6027,\u8981\u627e\u51fa\u539f\u56e0\u5b9e\u9645\u4e0a\u662f\u65e0\u6cd5\u505a\u5230\u7684\u3002<br>\n      \uff08\u5f88\u591a\u65f6\u5019,\u8fd9\u90fd\u4e0d\u662f\u5f88\u6709\u610f\u4e49\u7684\u63a2\u7d22\u3002\uff09\n  <\/p>\n  <h4>\u6765\u81ea\u6837\u672c\u7684\u751f\u7269\u5b66\u539f\u56e0<\/h4>\n      <ul>\n          <li>\u6000\u5b55\u5468\u6570\u4e0d\u8db3 (\u5468\u6570\u8d8a\u591aFF\u8d8a\u5927)\u203b5<\/li>\n          <li>\u9876\u81c0\u957f (CRL) \u6570\u503c\u8f83\u5c0f (\u6570\u503c\u8d8a\u5927FF\u8d8a\u5927)\u203b6<\/li>\n          <li>\u5d4c\u5408\u4f53\u73b0\u8c61 (FF\u51cf\u5c11)\u203b7<\/li>\n          <li>\u80ce\u513f\u6709\u975e\u6574\u500d\u6027 (\u5bf9FF\u7684\u5f71\u54cd\u6709\u6240\u4e0d\u540c)\u203b8,9,10,11<\/li>\n          <li>\u4e09\u500d\u4f53 (FF\u51cf\u5c11)\u203b12<\/li>\n          <li>\u591a\u80de\u80ce\u598a\u5a20 (\u603bFF\u589e\u52a0,\u4f46\u6bcf\u4e2a\u80ce\u513f\u7684FF\u51cf\u5c11)\u203b13,14<\/li>\n      <\/ul>\n      <p style=\"margin-bottom: 0;\">(\u4ee5\u4e0b\u662f\u6765\u81ea\u6bcd\u4f53\u7684\u751f\u7269\u5b66\u539f\u56e0)<\/p>\n      <ul>\n          <li>\u6bcd\u4f53BMI\u589e\u9ad8 (\u8d8a\u9ad8FF\u5c31\u8d8a\u5c11)\u203b8,5,15<\/li>\n          <li>\u6bcd\u4eb2\u81ea\u4f53\u514d\u75ab\u6027\u75be\u75c5 (\u75be\u75c5\u6d3b\u6027\u8d8a\u9ad8, FF\u8d8a\u4f4e)\u203b16,17,18<\/li>\n          <li>\u670d\u7528\u4f4e\u5206\u5b50\u91cf\u809d\u7d20\u836f\u7269 (FF\u6709\u53ef\u80fd\u964d\u4f4e)\u203b19,20,21,22<\/li>\n          <li>\u8840\u6e05\u4e2d\u6000\u5b55\u76f8\u5173\u7684\u8840\u6d46\u86cb\u767dPaPP-A (FF\u589e\u52a0)\u203b6,23<\/li>\n          <li>\u8840\u6e05\u6e38\u79bb\u03b2-HCG (FF\u5347\u9ad8)\u203b6,24<\/li>\n          <li>\u79cd\u65cf\u5dee\u5f02 (\u5bf9FF\u7684\u5f71\u54cd\u5404\u4e0d\u76f8\u540c)\u203b6,14,25<\/li>\n          <li>\u8f85\u52a9\u751f\u6b96\u6280\u672fART\u53d7\u5b55 (FF\u51cf\u5c11)\u203b24<\/li>\n          <li>\u751f\u4ea7\u6b21\u6570 (FF\u51cf\u5c11)\u203b14, 25<\/li>\n          <li>\u4ea7\u5987\u5e74\u9f84 (FF\u51cf\u5c11)\u203b14, 25<\/li>\n      <\/ul>\n  <p>\n      \u9057\u61be\u7684\u662f,\u5982\u4e0a\u6240\u8ff0,\u5c06\u8fd9\u79cd\u751f\u7269\u5b66\u539f\u56e0\u52a0\u4ee5\u9650\u5236\u51e0\u4e4e\u662f\u4e0d\u53ef\u80fd\u7684\u3002<br>\n     \u5bf9\u6240\u6709\u53ef\u80fd\u6027\u8fdb\u884c\u4e13\u4e1a\u9a8c\u8bc1\u9700\u8981\u82b1\u8d39\u5927\u91cf\u7684\u65f6\u95f4\u548c\u91d1\u94b1,\u800c\u8fd9\u5e76\u4e0d\u73b0\u5b9e,\u5373\u4f7f\u627e\u5230\u4e86\u539f\u56e0,\u5728\u8bb8\u591a\u60c5\u51b5\u4e0bNIPT\u68c0\u67e5\u5bf9\u4e8e\u53d7\u8bd5\u8005\u6765\u8bf4\u662f\u4e0d\u5408\u9002\u7684\u3002\n  <\/p>\n<div class=\"cyprus_cta\">\n<img decoding=\"async\" src=\"\/nipt\/wp-content\/uploads\/2023\/02\/cyprus-cta_top.png\" alt=\"\u5fae\u5c0f\u6b20\u5931\u30d7\u30e9\u30f3cta\u30dc\u30bf\u30f3\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/plan\/n-guard\/?lang=zh-hans\"><img decoding=\"async\" src=\"\/nipt\/wp-content\/uploads\/2023\/02\/cyprus-cta_middle.png\" alt=\"\u5fae\u5c0f\u6b20\u5931\u30d7\u30e9\u30f3\u4e00\u89a7\"><\/a>\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/?wp\"><img decoding=\"async\" src=\"\/nipt\/wp-content\/uploads\/2023\/02\/cyprus-cta_bottom.png\" alt=\"\u51fa\u751f\u524d\u8a3a\u65ad\u4e88\u7d04\u30dc\u30bf\u30f3\"><\/a>\n<\/div>\n\n<style>\n.cyprus_cta{\nmax-width: 500px !important;\nwidth: 100%;\nmargin: 0 auto;\n}\n.cyprus_cta a{\ndisplay: block;\n}\n.cyprus_cta a img:not(first-child){\nmargin-top: -8px;\n}\n<\/style>\n  <p class=\"sankou\">\u3010\u53c2\u8003\u6587\u732e\u3011<\/p>\n  <ul class=\"number\">\n      <li>Yaron Y. The implications of non-invasive prenatal testing failures: a review of an under-discussed phenomenon. Prenat Diagn. 2016;36:391-396.<\/li>\n      <li>Kinnings SL, Geis JA, Almasri E, et al. Factors affecting levels of circulating cell-free fetal DNA in maternal plasma and their implications for noninvasive prenatal testing. Prenat Diagn. 2015;35:816-822.<\/li>\n      <li>Hui L, Teoh M, da Silva Costa F, et al. Clinical implementation of cell free DNA based aneuploidy screening: perspectives from a national audit. Ultrasound Obstet Gynecol. 2015;45:10-15.<\/li>\n      <li>Ashoor G, Syngelaki A, Poon LC, Rezende JC, Nicolaides KH. Fetal fraction in maternal plasma cell-free DNA at 11-13 weeks&#8217; gestation: relation to maternal and fetal characteristics. Ultrasound Obstet Gynecol. 2013;41:26-32.<\/li>\n      <li>Kinnings SL, Geis JA, Almasri E, et al. Factors affecting levels of circulating cell-free fetal DNA in maternal plasma and their implications for noninvasive prenatal testing. Prenat Diagn. 2015;35:816-822.<\/li>\n      <li>Ashoor G, Syngelaki A, Poon LC, Rezende JC, Nicolaides KH. Fetal fraction in maternal plasma cell-free DNA at 11-13 weeks&#8217; gestation: relation to maternal and fetal characteristics. Ultrasound Obstet Gynecol. 2013;41:26-32.<\/li>\n      <li>Brison N, Neofytou M, Dehaspe L, et al. Predicting fetoplacental chromosomal mosaicism during noninvasive prenatal testing. Prenat Diagn. 2018;38(4):258-266. https:\/\/doi.org\/10.1002\/pd.5223.<\/li>\n      <li>Ashoor G, Syngelaki A, Poon LC, Rezende JC, Nicolaides KH. Fetal fraction in maternal plasma cell-free DNA at 11-13 weeks&#8217; gestation: relation to maternal and fetal characteristics. Ultrasound Obstet Gynecol. 2013;41:26-32.<\/li>\n      <li>Kinnings SL, Geis JA, Almasri E, et al. Factors affecting levels of circulating cell-free fetal DNA in maternal plasma and their implications for noninvasive prenatal testing. Prenat Diagn. 2015;35:816-822.<\/li>\n      <li>Palomaki GE, Kloza EM, Lambert-Messerlian GM, et al. Circulating cell free DNA testing: are some test failures informative? Prenat Diagn. 2015;35:289-293.<\/li>\n      <li>Rava RP, Srinivasan A, Sehnert AJ, Bianchi DW. Circulating fetal cell free DNA fractions differ in autosomal aneuploidies and monosomy X. Clin Chem. 2014;60:243-250.<\/li>\n      <li>Nicolaides KH, Syngelaki A, del Mar Gil M, Quezada MS, Zinevich Y. Prenatal detection of fetal triploidy from cell-free DNA testing in maternal blood. Fetal Diagn Ther. 2014;35(3):212-217.<\/li>\n      <li>Hedriana H, Martin K, Saltzman D, Billings P, Demko Z, Benn P. Cell Free DNA fetal fraction in twin gestations in single nucleotide polymorphism-based non-invasive prenatal screening. 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