{"id":100565,"date":"2025-06-05T15:45:25","date_gmt":"2025-06-05T06:45:25","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/?p=100565"},"modified":"2026-03-04T11:58:37","modified_gmt":"2026-03-04T02:58:37","slug":"nipt-types-comparison-guide","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/","title":{"rendered":"NIPT\uff08\u65b0\u578b\u51fa\u751f\u524d\u8a3a\u65ad\uff09\u306e\u7a2e\u985e\u3068\u7cbe\u5ea6\u3092\u3084\u3055\u3057\u304f\u89e3\u8aac\uff1a\u9078\u3073\u65b9\u306e\u53c2\u8003\u306b"},"content":{"rendered":"\n<div style=\"border:solid #ffe6e6 0.8rem;background-color: #fff9f9;padding:3% 5%;margin:1rem 0 3rem;\"><h2 style=\"margin-top:1rem;\">\u3053\u306e\u8a18\u4e8b\u306e\u307e\u3068\u3081<\/h2><p>\u3053\u306e\u30da\u30fc\u30b8\u306f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>\uff08\u975e\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\uff09\u306e\u5404\u624b\u6cd5\u306b\u3064\u3044\u3066\u30012025\u5e74\u6642\u70b9\u306e\u6700\u65b0\u60c5\u5831\u3092\u53cd\u6620\u3057\u3066\u66f4\u65b0\u3055\u308c\u305f\u5185\u5bb9\u3067\u3059\u3002\u598a\u5a66\u306e\u65b9\u3005\u3084\u3054\u5bb6\u65cf\u304c\u81ea\u5206\u306b\u5408\u3063\u305f\u691c\u67fb\u3092\u9078\u3076\u305f\u3081\u306e\u60c5\u5831\u63d0\u4f9b\u3092\u76ee\u7684\u306b\u4f5c\u6210\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u533b\u5b66\u751f\u3084\u533b\u7642\u5f93\u4e8b\u8005\u306b\u3068\u3063\u3066\u306e\u57fa\u790e\u7684\u306a\u53c2\u8003\u8cc7\u6599\u3068\u3057\u3066\u3082\u3054\u6d3b\u7528\u3044\u305f\u3060\u3051\u308b\u3053\u3068\u3092\u9858\u3063\u3066\u3044\u307e\u3059\u3002<\/p><\/div>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#NIPT%E3%82%92%E6%A4%9C%E8%A8%8E%E3%81%99%E3%82%8B%E5%B0%86%E6%9D%A5%E3%81%AE%E5%A6%8A%E5%A9%A6%E3%81%AB%E3%81%A8%E3%81%A3%E3%81%A6%E3%81%AE%E4%B8%BB%E3%81%AA%E3%83%9D%E3%82%A4%E3%83%B3%E3%83%88\" >NIPT\u3092\u691c\u8a0e\u3059\u308b\u5c06\u6765\u306e\u598a\u5a66\u306b\u3068\u3063\u3066\u306e\u4e3b\u306a\u30dd\u30a4\u30f3\u30c8<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#1_NIPT%E3%81%AF%E4%B8%80%E8%88%AC%E7%9A%84%E3%81%AA%E9%81%BA%E4%BC%9D%E6%80%A7%E7%96%BE%E6%82%A3%E3%81%AE%E6%A4%9C%E5%87%BA%E3%81%AB%E3%81%8A%E3%81%84%E3%81%A6%E9%9D%9E%E5%B8%B8%E3%81%AB%E9%AB%98%E3%81%84%E7%B2%BE%E5%BA%A6%E3%82%92%E6%8C%81%E3%81%A4\" >1. NIPT\u306f\u4e00\u822c\u7684\u306a\u907a\u4f1d\u6027\u75be\u60a3\u306e\u691c\u51fa\u306b\u304a\u3044\u3066\u975e\u5e38\u306b\u9ad8\u3044\u7cbe\u5ea6\u3092\u6301\u3064<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#2_%E3%81%99%E3%81%B9%E3%81%A6%E3%81%AENIPT%E6%89%8B%E6%B3%95%E3%81%AF%E9%AB%98%E3%81%84%E7%B2%BE%E5%BA%A6%E3%82%92%E6%8C%81%E3%81%A4%E3%81%8C%E3%80%81%E8%8B%A5%E5%B9%B2%E6%80%A7%E8%83%BD%E3%81%AB%E5%B7%AE%E3%81%8C%E3%81%82%E3%82%8B\" >2. \u3059\u3079\u3066\u306eNIPT\u624b\u6cd5\u306f\u9ad8\u3044\u7cbe\u5ea6\u3092\u6301\u3064\u304c\u3001\u82e5\u5e72\u6027\u80fd\u306b\u5dee\u304c\u3042\u308b<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#4%E3%81%A4%E3%81%AE%E4%B8%BB%E8%A6%81%E6%89%8B%E6%B3%95\" >4\u3064\u306e\u4e3b\u8981\u624b\u6cd5<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E5%85%A8%E3%82%B2%E3%83%8E%E3%83%A0%E3%82%B7%E3%83%BC%E3%82%B1%E3%83%B3%E3%82%B7%E3%83%B3%E3%82%B0%EF%BC%88WGS%EF%BC%9BWhole_Genome_Sequencing%EF%BC%89\" >\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\uff08WGS\uff1bWhole Genome Sequencing\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#SNP%E3%83%99%E3%83%BC%E3%82%B9%E3%81%AE%E6%A4%9C%E6%9F%BB\" >SNP\u30d9\u30fc\u30b9\u306e\u691c\u67fb<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E3%83%AD%E3%83%BC%E3%83%AA%E3%83%B3%E3%82%B0%E3%82%B5%E3%83%BC%E3%82%AF%E3%83%AB%E5%A2%97%E5%B9%85%EF%BC%88RCA%EF%BC%9BRolling_Circle_Amplification%EF%BC%89\" >\u30ed\u30fc\u30ea\u30f3\u30b0\u30b5\u30fc\u30af\u30eb\u5897\u5e45\uff08RCA\uff1bRolling Circle Amplification\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E3%83%9E%E3%82%A4%E3%82%AF%E3%83%AD%E3%82%A2%E3%83%AC%E3%82%A4%E3%83%99%E3%83%BC%E3%82%B9%E3%81%AE%E6%A4%9C%E6%9F%BB\" >\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4\u30d9\u30fc\u30b9\u306e\u691c\u67fb<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E8%A6%AA%E3%81%AE%E3%81%9F%E3%82%81%E3%81%AENIPT%EF%BC%88%E9%9D%9E%E4%BE%B5%E8%A5%B2%E7%9A%84%E5%87%BA%E7%94%9F%E5%89%8D%E8%A8%BA%E6%96%AD%EF%BC%89%E6%8A%80%E8%A1%93\" >\u89aa\u306e\u305f\u3081\u306eNIPT\uff08\u975e\u4fb5\u8972\u7684\u51fa\u751f\u524d\u8a3a\u65ad\uff09\u6280\u8853<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#NIPT%E6%A4%9C%E6%9F%BB%E3%81%AF%E3%81%99%E3%81%B9%E3%81%A6%E5%90%8C%E3%81%98%E7%96%BE%E6%82%A3%E3%82%92%E8%AA%BF%E3%81%B9%E3%82%8B%E3%82%8F%E3%81%91%E3%81%A7%E3%81%AF%E3%81%82%E3%82%8A%E3%81%BE%E3%81%9B%E3%82%93\" >NIPT\u691c\u67fb\u306f\u3059\u3079\u3066\u540c\u3058\u75be\u60a3\u3092\u8abf\u3079\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E5%AE%9F%E7%94%A8%E7%9A%84%E3%81%AA%E9%81%95%E3%81%84%E3%82%82%E8%80%83%E6%85%AE%E3%81%99%E3%81%B9%E3%81%8D%E3%83%9D%E3%82%A4%E3%83%B3%E3%83%88\" >\u5b9f\u7528\u7684\u306a\u9055\u3044\u3082\u8003\u616e\u3059\u3079\u304d\u30dd\u30a4\u30f3\u30c8<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#3_%E9%99%BD%E6%80%A7%E7%B5%90%E6%9E%9C%E3%81%8C%E5%87%BA%E3%81%9F%E5%A0%B4%E5%90%88%E3%82%82%E3%80%81%E5%BF%85%E3%81%9A%E7%A2%BA%E5%AE%9A%E6%A4%9C%E6%9F%BB%E3%81%8C%E5%BF%85%E8%A6%81%E3%81%A7%E3%81%99\" >3. \u967d\u6027\u7d50\u679c\u304c\u51fa\u305f\u5834\u5408\u3082\u3001\u5fc5\u305a\u78ba\u5b9a\u691c\u67fb\u304c\u5fc5\u8981\u3067\u3059<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#4_NIPT%E3%81%AF%E5%AE%89%E5%85%A8%E3%81%A7%E9%9D%9E%E4%BE%B5%E8%A5%B2%E7%9A%84%E3%81%A7%E3%81%99\" >4. NIPT\u306f\u5b89\u5168\u3067\u975e\u4fb5\u8972\u7684\u3067\u3059<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#5_%E8%B6%85%E9%9F%B3%E6%B3%A2%E6%A4%9C%E6%9F%BB%E3%82%82%E4%BE%9D%E7%84%B6%E3%81%A8%E3%81%97%E3%81%A6%E5%BF%85%E8%A6%81%E3%81%A7%E3%81%99\" >5. \u8d85\u97f3\u6ce2\u691c\u67fb\u3082\u4f9d\u7136\u3068\u3057\u3066\u5fc5\u8981\u3067\u3059<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#6_NIPT%E3%81%AE%E3%83%96%E3%83%A9%E3%83%B3%E3%83%89%E3%81%AB%E3%81%AF%E9%81%95%E3%81%84%E3%81%8C%E3%81%82%E3%82%8A%E3%81%BE%E3%81%99\" >6. NIPT\u306e\u30d6\u30e9\u30f3\u30c9\u306b\u306f\u9055\u3044\u304c\u3042\u308a\u307e\u3059<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E3%81%93%E3%81%AE%E6%83%85%E5%A0%B1%E3%82%92%E3%81%A9%E3%81%86%E6%B4%BB%E7%94%A8%E3%81%99%E3%81%B9%E3%81%8D%E3%81%8B%EF%BC%9F\" >\u3053\u306e\u60c5\u5831\u3092\u3069\u3046\u6d3b\u7528\u3059\u3079\u304d\u304b\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E5%BC%95%E7%94%A8%E6%96%87%E7%8C%AE_References\" >\u5f15\u7528\u6587\u732e References<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E3%80%90%E8%A9%B3%E7%B4%B0%E8%A7%A3%E8%AA%AC%E3%80%91%E4%B8%80%E8%88%AC%E7%9A%84%E3%81%AA%E5%B8%B8%E6%9F%93%E8%89%B2%E4%BD%93%E7%95%B0%E6%95%B0%E6%80%A7%E3%82%B9%E3%82%AF%E3%83%AA%E3%83%BC%E3%83%8B%E3%83%B3%E3%82%B0%E3%81%AB%E3%81%8A%E3%81%91%E3%82%8BNIPT%E6%89%8B%E6%B3%95%E3%81%AE%E7%B2%BE%E5%BA%A6%E5%B7%AE%E3%81%AB%E9%96%A2%E3%81%99%E3%82%8B%E4%BD%93%E7%B3%BB%E7%9A%84%E3%83%AC%E3%83%93%E3%83%A5%E3%83%BC\" >\u3010\u8a73\u7d30\u89e3\u8aac\u3011\u4e00\u822c\u7684\u306a\u5e38\u67d3\u8272\u4f53\u7570\u6570\u6027\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u304a\u3051\u308bNIPT\u624b\u6cd5\u306e\u7cbe\u5ea6\u5dee\u306b\u95a2\u3059\u308b\u4f53\u7cfb\u7684\u30ec\u30d3\u30e5\u30fc<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E6%A6%82%E8%A6%81\" >\u6982\u8981<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#1_%E8%83%8C%E6%99%AF%E3%81%A8%E6%A0%B9%E6%8B%A0\" >1. \u80cc\u666f\u3068\u6839\u62e0<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E3%83%88%E3%83%AA%E3%82%BD%E3%83%9F%E3%83%BC%E6%A4%9C%E5%87%BA%E3%81%AE%E8%87%A8%E5%BA%8A%E7%9A%84%E9%87%8D%E8%A6%81%E6%80%A7\" >\u30c8\u30ea\u30bd\u30df\u30fc\u691c\u51fa\u306e\u81e8\u5e8a\u7684\u91cd\u8981\u6027<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#NIPT%E6%8A%80%E8%A1%93%E3%81%AE%E6%A6%82%E8%A6%81\" >NIPT\u6280\u8853\u306e\u6982\u8981<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E5%90%84%E6%89%8B%E6%B3%95%E3%81%AE%E7%89%B9%E5%BE%B4\" >\u5404\u624b\u6cd5\u306e\u7279\u5fb4<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#2_%E7%9B%AE%E7%9A%84\" >2. \u76ee\u7684<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#3_%E6%96%B9%E6%B3%95%E8%AB%96\" >3. \u65b9\u6cd5\u8ad6<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E3%83%87%E3%83%BC%E3%82%BF%E3%82%BD%E3%83%BC%E3%82%B9%E3%81%A8%E6%A4%9C%E7%B4%A2%E6%88%A6%E7%95%A5\" >\u30c7\u30fc\u30bf\u30bd\u30fc\u30b9\u3068\u691c\u7d22\u6226\u7565<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E9%81%B8%E5%AE%9A%E5%9F%BA%E6%BA%96\" >\u9078\u5b9a\u57fa\u6e96<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-28\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E3%83%87%E3%83%BC%E3%82%BF%E6%8A%BD%E5%87%BA%E9%A0%85%E7%9B%AE\" >\u30c7\u30fc\u30bf\u62bd\u51fa\u9805\u76ee<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-29\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E7%B5%B1%E8%A8%88%E5%87%A6%E7%90%86\" >\u7d71\u8a08\u51e6\u7406<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-30\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#4_%E7%B5%90%E6%9E%9C\" >4. \u7d50\u679c<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-31\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#41_%E5%AF%BE%E8%B1%A1%E7%A0%94%E7%A9%B6%E3%81%AE%E6%A6%82%E8%A6%81\" >4.1. \u5bfe\u8c61\u7814\u7a76\u306e\u6982\u8981<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-32\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#42_%E6%9F%93%E8%89%B2%E4%BD%93%E7%95%B0%E5%B8%B8%E5%88%A5%E3%81%8A%E3%82%88%E3%81%B3%E6%89%8B%E6%B3%95%E5%88%A5%E3%81%AE%E8%A8%BA%E6%96%AD%E7%B2%BE%E5%BA%A6\" >4.2. \u67d3\u8272\u4f53\u7570\u5e38\u5225\u304a\u3088\u3073\u624b\u6cd5\u5225\u306e\u8a3a\u65ad\u7cbe\u5ea6<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-33\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E3%83%88%E3%83%AA%E3%82%BD%E3%83%9F%E3%83%BC21%EF%BC%88%E3%83%80%E3%82%A6%E3%83%B3%E7%97%87%EF%BC%89\" >\u30c8\u30ea\u30bd\u30df\u30fc21\uff08\u30c0\u30a6\u30f3\u75c7\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-34\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E3%83%88%E3%83%AA%E3%82%BD%E3%83%9F%E3%83%BC18\" >\u30c8\u30ea\u30bd\u30df\u30fc18<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-35\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E3%83%88%E3%83%AA%E3%82%BD%E3%83%9F%E3%83%BC13\" >\u30c8\u30ea\u30bd\u30df\u30fc13<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-36\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#5_%E8%80%83%E5%AF%9F\" >5. \u8003\u5bdf<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-37\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#51_%E8%A7%A3%E9%87%88\" >5.1. \u89e3\u91c8<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-38\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#52_%E7%B5%8C%E6%B8%88%E7%9A%84%E3%83%BB%E8%87%A8%E5%BA%8A%E7%9A%84%E8%A6%B3%E7%82%B9\" >5.2. \u7d4c\u6e08\u7684\u30fb\u81e8\u5e8a\u7684\u89b3\u70b9<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-39\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#53_%E6%96%B9%E6%B3%95%E8%AB%96%E4%B8%8A%E3%81%AE%E7%95%99%E6%84%8F%E7%82%B9\" >5.3. \u65b9\u6cd5\u8ad6\u4e0a\u306e\u7559\u610f\u70b9<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-40\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#6_%E9%99%90%E7%95%8C\" >6. \u9650\u754c<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-41\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#7_%E7%B5%90%E8%AB%96\" >7. \u7d50\u8ad6<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-42\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E4%B8%BB%E3%81%AA%E6%89%80%E8%A6%8B\" >\u4e3b\u306a\u6240\u898b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-43\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E8%87%A8%E5%BA%8A%E7%9A%84%E6%8E%A8%E5%A5%A8\" >\u81e8\u5e8a\u7684\u63a8\u5968<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-44\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#8_%E4%BB%8A%E5%BE%8C%E3%81%AE%E7%A0%94%E7%A9%B6%E3%81%B8%E3%81%AE%E7%A4%BA%E5%94%86\" >8. \u4eca\u5f8c\u306e\u7814\u7a76\u3078\u306e\u793a\u5506<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-45\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/#%E7%94%A8%E8%AA%9E%E9%9B%86\" >\u7528\u8a9e\u96c6<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading custom-heading2\"><span class=\"ez-toc-section\" id=\"NIPT%E3%82%92%E6%A4%9C%E8%A8%8E%E3%81%99%E3%82%8B%E5%B0%86%E6%9D%A5%E3%81%AE%E5%A6%8A%E5%A9%A6%E3%81%AB%E3%81%A8%E3%81%A3%E3%81%A6%E3%81%AE%E4%B8%BB%E3%81%AA%E3%83%9D%E3%82%A4%E3%83%B3%E3%83%88\"><\/span>NIPT\u3092\u691c\u8a0e\u3059\u308b\u5c06\u6765\u306e\u598a\u5a66\u306b\u3068\u3063\u3066\u306e\u4e3b\u306a\u30dd\u30a4\u30f3\u30c8<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_NIPT%E3%81%AF%E4%B8%80%E8%88%AC%E7%9A%84%E3%81%AA%E9%81%BA%E4%BC%9D%E6%80%A7%E7%96%BE%E6%82%A3%E3%81%AE%E6%A4%9C%E5%87%BA%E3%81%AB%E3%81%8A%E3%81%84%E3%81%A6%E9%9D%9E%E5%B8%B8%E3%81%AB%E9%AB%98%E3%81%84%E7%B2%BE%E5%BA%A6%E3%82%92%E6%8C%81%E3%81%A4\"><\/span><strong>1. NIPT\u306f\u4e00\u822c\u7684\u306a\u907a\u4f1d\u6027\u75be\u60a3\u306e\u691c\u51fa\u306b\u304a\u3044\u3066\u975e\u5e38\u306b\u9ad8\u3044\u7cbe\u5ea6\u3092\u6301\u3064<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u5065\u5eb7\u306a\u4eba\u9593\u306f\u901a\u5e38\u300123\u5bfe\u306e\u67d3\u8272\u4f53\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u67d3\u8272\u4f53\u3068\u306fDNA\u3067\u69cb\u6210\u3055\u308c\u305f\u907a\u4f1d\u60c5\u5831\u306e\u30d1\u30c3\u30b1\u30fc\u30b8\u3067\u3042\u308a\u3001\u8eab\u4f53\u306e\u6210\u9577\u3068\u6a5f\u80fd\u306b\u95a2\u3059\u308b\u6307\u793a\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002<br>\u975e\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>\uff09\u306f\u3001\u80ce\u5150\u306b\u7279\u5b9a\u306e\u907a\u4f1d\u6027\u75be\u60a3\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u5229\u7528\u53ef\u80fd\u306a\u6700\u3082\u6b63\u78ba\u306a\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u624b\u6cd5\u306e\u4e00\u3064\u3067\u3059\u3002\u7279\u306b\u3001\u4ee5\u4e0b\u306e\u4e09\u3064\u306e\u6700\u3082\u4e00\u822c\u7684\u306a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u7279\u5b9a\u306b\u3088\u304f\u7528\u3044\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\u5019\u7fa4\uff08\u30c8\u30ea\u30bd\u30df\u30fc21\uff09<br><\/li>\n\n\n\n<li>\u30a8\u30c9\u30ef\u30fc\u30ba\u75c7\u5019\u7fa4\uff08\u30c8\u30ea\u30bd\u30df\u30fc18\uff09<br><\/li>\n\n\n\n<li>\u30d1\u30c8\u30a6\u75c7\u5019\u7fa4\uff08\u30c8\u30ea\u30bd\u30df\u30fc13\uff09<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u75be\u60a3\u306f\u3001\u67d3\u8272\u4f53\u304c\u4e00\u672c\u591a\u304f\u5b58\u5728\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u305f\u3081\u3001\u300c\u30c8\u30ea\u30bd\u30df\u30fc\u300d\u3068\u547c\u3070\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u75be\u60a3\u306f\u305d\u308c\u305e\u308c\u7570\u306a\u308b\u304b\u305f\u3061\u3067\u80ce\u5150\u306e\u767a\u9054\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<p>NIPT\u306e\u7cbe\u5ea6\u306f\u3001\u611f\u5ea6\uff08sensitivity\uff09\u3068\u7279\u7570\u5ea6\uff08specificity\uff09\u3068\u3044\u30462\u3064\u306e\u91cd\u8981\u306a\u6307\u6a19\u306b\u3088\u3063\u3066\u6e2c\u5b9a\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u611f\u5ea6\u3068\u306f\u3001\u5b9f\u969b\u306b\u75be\u60a3\u304c\u5b58\u5728\u3059\u308b\u5834\u5408\u306b\u3001\u3069\u308c\u3060\u3051\u6b63\u3057\u304f\u305d\u308c\u3092\u691c\u51fa\u3067\u304d\u308b\u304b\u3092\u793a\u3059\u6307\u6a19\u3067\u3059\u3002\u3064\u307e\u308a\u3001\u672c\u5f53\u306b\u3053\u308c\u3089\u306e\u30c8\u30ea\u30bd\u30df\u30fc\u3092\u6301\u3064\u80ce\u5150\u3092\u6b63\u3057\u304f\u8b58\u5225\u3067\u304d\u308b\u80fd\u529b\u3092\u8868\u3057\u307e\u3059\u3002<br>\u3059\u3079\u3066\u306eNIPT\u306e\u7a2e\u985e\u306b\u304a\u3044\u3066\u611f\u5ea6\u306f97\u301c99%\u4ee5\u4e0a\u3067\u3042\u308a\u3001\u3064\u307e\u308a\u75be\u60a3\u304c\u5b58\u5728\u3059\u308b\u5834\u5408\u306b\u306f\u307b\u307c\u5fc5\u305a\u691c\u51fa\u3055\u308c\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<br><\/li>\n\n\n\n<li>\u7279\u7570\u5ea6\u3068\u306f\u3001\u5b9f\u969b\u306b\u75be\u60a3\u304c\u5b58\u5728\u3057\u306a\u3044\u5834\u5408\u306b\u3001\u305d\u308c\u3092\u6b63\u3057\u304f\u300c\u7570\u5e38\u306a\u3057\u300d\u3068\u5224\u65ad\u3067\u304d\u308b\u304b\u3092\u793a\u3059\u6307\u6a19\u3067\u3059\u3002\u3053\u308c\u306f\u3001\u8aa4\u3063\u3066\u8b66\u544a\u3092\u51fa\u3059\u3053\u3068\uff08\u507d\u967d\u6027\uff09\u3092\u3069\u308c\u3060\u3051\u9632\u3052\u308b\u304b\u3092\u8868\u3057\u307e\u3059\u3002<br>NIPT\u306e\u7279\u7570\u5ea6\u306f\u5e38\u306b99%\u4ee5\u4e0a\u3067\u3042\u308a\u3001\u80ce\u5150\u304c\u3053\u308c\u3089\u306e\u75be\u60a3\u3092\u6301\u305f\u306a\u3044\u5834\u5408\u3001\u305d\u308c\u3092\u975e\u5e38\u306b\u4fe1\u983c\u6027\u9ad8\u304f\u9664\u5916\u3067\u304d\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p>\u307e\u3068\u3081\u308b\u3068\u3001NIPT\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\u5019\u7fa4\u3001\u30a8\u30c9\u30ef\u30fc\u30ba\u75c7\u5019\u7fa4\u3001\u30d1\u30c8\u30a6\u75c7\u5019\u7fa4\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u304a\u3044\u3066\u975e\u5e38\u306b\u9ad8\u3044\u7cbe\u5ea6\u3092\u6301\u3064\u691c\u67fb\u3067\u3042\u308a\u3001\u9ad8\u3044\u611f\u5ea6\u306b\u3088\u308a\u3053\u308c\u3089\u306e\u75be\u60a3\u304c\u3042\u308b\u5834\u5408\u306b\u307b\u307c\u78ba\u5b9f\u306b\u691c\u51fa\u3057\u3001\u9ad8\u3044\u7279\u7570\u5ea6\u306b\u3088\u308a\u8aa4\u3063\u305f\u967d\u6027\u7d50\u679c\u3092\u51fa\u3059\u3053\u3068\u306f\u975e\u5e38\u306b\u7a00\u3067\u3059\u3002<\/p>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_%E3%81%99%E3%81%B9%E3%81%A6%E3%81%AENIPT%E6%89%8B%E6%B3%95%E3%81%AF%E9%AB%98%E3%81%84%E7%B2%BE%E5%BA%A6%E3%82%92%E6%8C%81%E3%81%A4%E3%81%8C%E3%80%81%E8%8B%A5%E5%B9%B2%E6%80%A7%E8%83%BD%E3%81%AB%E5%B7%AE%E3%81%8C%E3%81%82%E3%82%8B\"><\/span><strong>2. \u3059\u3079\u3066\u306eNIPT\u624b\u6cd5\u306f\u9ad8\u3044\u7cbe\u5ea6\u3092\u6301\u3064\u304c\u3001\u82e5\u5e72\u6027\u80fd\u306b\u5dee\u304c\u3042\u308b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4%E3%81%A4%E3%81%AE%E4%B8%BB%E8%A6%81%E6%89%8B%E6%B3%95\"><\/span><strong>4\u3064\u306e\u4e3b\u8981\u624b\u6cd5<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u73fe\u5728\u3001\u3044\u304f\u3064\u304b\u306e\u975e\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>\uff09\u306e\u7a2e\u985e\u304c\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\u3002\u3059\u3079\u3066\u9ad8\u7cbe\u5ea6\u3067\u3059\u304c\u3001\u305d\u308c\u305e\u308c\u7570\u306a\u308b\u6280\u8853\u3092\u7528\u3044\u3066\u304a\u308a\u3001\u56fa\u6709\u306e\u5f37\u307f\u3001\u5236\u9650\u3001\u81e8\u5e8a\u5fdc\u7528\u304c\u3042\u308a\u307e\u3059\u3002\u3069\u306eNIPT\u624b\u6cd5\u304c\u6700\u9069\u304b\u306f\u3001\u6c42\u3081\u308b\u60c5\u5831\u306e\u7a2e\u985e\u3001\u691c\u67fb\u6642\u671f\u3001\u7cbe\u5ea6\u30fb\u8cbb\u7528\u30fb\u7d50\u679c\u307e\u3067\u306e\u6642\u9593\u306b\u5bfe\u3059\u308b\u5e0c\u671b\u306a\u3069\u3001\u500b\u5225\u306e\u30cb\u30fc\u30ba\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002\u4e2d\u306b\u306f\u5168\u30b2\u30ce\u30e0\u3092\u5bfe\u8c61\u3068\u3059\u308b\u5e83\u7bc4\u306a\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u63d0\u4f9b\u3059\u308b\u3082\u306e\u3082\u3042\u308c\u3070\u3001\u4e00\u822c\u7684\u306a\u75be\u60a3\u306b\u7279\u5316\u3057\u3066\u3044\u308b\u3082\u306e\u3082\u3042\u308a\u307e\u3059\u3002\u80ce\u5150DNA\uff08fetal fraction\uff09\u304c\u5c11\u306a\u3044\u5834\u5408\u306e\u5bfe\u5fdc\u3001\u507d\u967d\u6027\u306e\u30ea\u30b9\u30af\u3001\u7d50\u679c\u306e\u8fd4\u5374\u30b9\u30d4\u30fc\u30c9\u3001\u30b3\u30b9\u30c8\u306b\u3082\u9055\u3044\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%85%A8%E3%82%B2%E3%83%8E%E3%83%A0%E3%82%B7%E3%83%BC%E3%82%B1%E3%83%B3%E3%82%B7%E3%83%B3%E3%82%B0%EF%BC%88WGS%EF%BC%9BWhole_Genome_Sequencing%EF%BC%89\"><\/span><strong>\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\uff08WGS\uff1bWhole Genome Sequencing\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u6700\u3082\u5305\u62ec\u7684\u3067\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u308bNIPT\u624b\u6cd5\u306e\u4e00\u3064\u304c\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\uff08WGS\uff09\u3067\u3059\u3002\u3053\u306e\u624b\u6cd5\u306f\u3001\u6bcd\u4f53\u306e\u8840\u6db2\u4e2d\u306b\u5b58\u5728\u3059\u308b\u80ce\u76e4\u7531\u6765\u306e\u904a\u96e2DNA\uff08cfDNA\uff09\u306e\u5c0f\u7247\u3092\u5206\u6790\u3057\u307e\u3059\u3002\u80ce\u76e4\u306eDNA\u306f\u901a\u5e38\u3001\u80ce\u5150\u306e\u907a\u4f1d\u60c5\u5831\u3092\u53cd\u6620\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>WGS\u3067\u306f\u3001\u4f4e\u6df1\u5ea6\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\uff08low-pass sequencing\uff09\u3068\u3044\u3046\u65b9\u6cd5\u3067\u5168\u67d3\u8272\u4f53\u306b\u308f\u305f\u3063\u3066\u4f55\u767e\u4e07\u3082\u306ecfDNA\u65ad\u7247\u3092\u8aad\u307f\u53d6\u308a\u307e\u3059\u3002\u3059\u3079\u3066\u306e\u907a\u4f1d\u5b50\u3092\u8a73\u7d30\u306b\u30b9\u30ad\u30e3\u30f3\u3059\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u5404\u67d3\u8272\u4f53\u306b\u304a\u3051\u308bDNA\u91cf\u306e\u9055\u3044\u3092\u691c\u51fa\u3067\u304d\u308b\u3060\u3051\u306e\u30c7\u30fc\u30bf\u306f\u53d6\u5f97\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001WGS\u306f\u30c8\u30ea\u30bd\u30df\u30fc21\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\uff09\u3001\u30c8\u30ea\u30bd\u30df\u30fc18\uff08\u30a8\u30c9\u30ef\u30fc\u30ba\u75c7\u5019\u7fa4\uff09\u3001\u30c8\u30ea\u30bd\u30df\u30fc13\uff08\u30d1\u30c8\u30a6\u75c7\u5019\u7fa4\uff09\u3068\u3044\u3063\u305f\u4e3b\u8981\u306a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3092\u9ad8\u7cbe\u5ea6\u3067\u7279\u5b9a\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>WGS\u306f\u4ed6\u306e\u624b\u6cd5\u3068\u6bd4\u3079\u3066\u300cno-call\u7387\uff08\u5224\u5b9a\u4e0d\u80fd\u7387\uff09\u300d\u304c\u4f4e\u304f\u3001\u80ce\u5150DNA\u306e\u5272\u5408\u304c\u5c11\u306a\u3044\u5834\u5408\u3067\u3082\u5b89\u5b9a\u3057\u3066\u7d50\u679c\u3092\u8fd4\u3059\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"SNP%E3%83%99%E3%83%BC%E3%82%B9%E3%81%AE%E6%A4%9C%E6%9F%BB\"><\/span><strong>SNP\u30d9\u30fc\u30b9\u306e\u691c\u67fb<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>SNP\u30d9\u30fc\u30b9\u306e\u691c\u67fb\u306f\u3001\u4e00\u5869\u57fa\u591a\u578b\uff08SNP\uff1asingle nucleotide polymorphism\uff09\u3068\u547c\u3070\u308c\u308b\u3001\u30b2\u30ce\u30e0\u4e0a\u3067\u4eba\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u5869\u57fa\u914d\u5217\uff08A\u3001T\u3001G\u3001C\uff09\u306b\u6ce8\u76ee\u3057\u307e\u3059\u3002\u6bcd\u4f53\u306eDNA\u3068\u80ce\u76e4\u7531\u6765cfDNA\u3092\u6bd4\u8f03\u3057\u3001\u305d\u308c\u305e\u308c\u306e\u89aa\u304b\u3089\u3069\u308c\u3060\u3051\u306e\u907a\u4f1d\u7269\u8cea\u304c\u7531\u6765\u3057\u3066\u3044\u308b\u304b\u3092\u63a8\u5b9a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u9ad8\u5ea6\u306a\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u306b\u3088\u308a\u3001\u67d3\u8272\u4f53\u4e0a\u306e\u30a2\u30ec\u30eb\uff08\u907a\u4f1d\u5b50\u306e\u578b\uff09\u306e\u5206\u5e03\u3092\u89e3\u6790\u3057\u307e\u3059\u3002\u3082\u3057\u6bd4\u7387\u304c\u7570\u5e38\u3067\u3042\u308c\u3070\uff08\u4f8b\u3048\u3070\u3001\u3042\u308b\u67d3\u8272\u4f53\u306b\u4e88\u60f3\u4ee5\u4e0a\u306e\u30a2\u30ec\u30eb\u304c\u3042\u308b\u306a\u3069\uff09\u3001\u4f59\u5206\u306a\u67d3\u8272\u4f53\u306e\u5b58\u5728\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>SNP\u30d9\u30fc\u30b9\u306eNIPT\u3082\u9ad8\u7cbe\u5ea6\u3067\u3059\u304c\u3001WGS\u3088\u308a\u3084\u3084\u507d\u967d\u6027\u7387\u304c\u9ad8\u304f\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u80ce\u5150DNA\u304c\u5c11\u306a\u3044\u5834\u5408\u306b\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u304f\u3001\u89aa\u5b50\u9593\u306e\u907a\u4f1d\u7684\u9055\u3044\u304c\u5c11\u306a\u3044\u5834\u5408\u3084\u4fe1\u53f7\u304c\u66d6\u6627\u306a\u5834\u5408\u306b\u306f\u7d50\u679c\u304c\u51fa\u306a\u3044\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>SNP\u30d9\u30fc\u30b9NIPT\u306e\u4e3b\u306a\u5229\u70b9\u306e\u4e00\u3064\u306f\u53cc\u5b50\u598a\u5a20\u306b\u304a\u3051\u308b\u81e8\u5e8a\u7684\u4fa1\u5024\u3067\u3059\u3002\u3053\u306e\u624b\u6cd5\u3067\u306f\u3001\u598a\u5a209\u9031\u76ee\u304b\u3089\u53cc\u5b50\u304c\u4e00\u5375\u6027\uff08monozygotic\uff09\u304b\u4e8c\u5375\u6027\uff08dizygotic\uff09\u304b\u3092\u7279\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u53cc\u5b50\u304c\u4e8c\u5375\u6027\u3067\u3042\u308b\u3068\u8b58\u5225\u3055\u308c\u308b\u5834\u5408\u3001\u305d\u308c\u306f2\u3064\u306e\u7570\u306a\u308b\u5375\u304b\u3089\u767a\u751f\u3057\u3066\u304a\u308a\u3001\u901a\u5e38\u306f2\u3064\u306e\u80ce\u76e4\u3092\u6301\u3064\uff08\u4e8c\u7d68\u6bdb\u819c\u6027\uff09\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001DNA\u304c\u4e00\u5375\u6027\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3059\u5834\u5408\u3001\u8d85\u97f3\u6ce2\u3067\u306f\u4e0d\u660e\u77ad\u3067\u3082\u3001\u4e00\u7d68\u6bdb\u819c\u6027\uff08monochorionic\uff09\u3068\u4eee\u5b9a\u3057\u3066\u598a\u5a20\u3092\u7ba1\u7406\u3059\u308b\u307b\u3046\u304c\u5b89\u5168\u3068\u3055\u308c\u307e\u3059\u3002\u306a\u305c\u306a\u3089\u3001\u4e00\u7d68\u6bdb\u819c\u6027\u53cc\u80ce\u3067\u306f\u7279\u5b9a\u306e\u5408\u4f75\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u3001\u3088\u308a\u53b3\u5bc6\u306a\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u304c\u5fc5\u8981\u306b\u306a\u308b\u305f\u3081\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001SNP\u30d9\u30fc\u30b9\u306eNIPT\u3067\u306f\u6d88\u5931\u53cc\u80ce\uff08vanishing twin\uff09\u306e\u5b58\u5728\u3082\u691c\u51fa\u3067\u304d\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u4e00\u65b9\u306e\u80ce\u5150\u304c\u598a\u5a20\u521d\u671f\u306b\u767a\u80b2\u3092\u505c\u6b62\u3057\u305f\u72b6\u6cc1\u3067\u3042\u308a\u3001\u7279\u306b\u4e8c\u5375\u6027\u53cc\u80ce\u3067\u767a\u751f\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u691c\u67fb\u6642\u70b9\u3067\u4e21\u65b9\u306e\u80ce\u5150\u7531\u6765cfDNA\u304c\u6bcd\u4f53\u306b\u6b8b\u3063\u3066\u3044\u308b\u5834\u5408\u3001\u3053\u308c\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002\u4ed6\u306eNIPT\u624b\u6cd5\u3067\u306f\u3053\u306e\u3088\u3046\u306a\u691c\u51fa\u304c\u96e3\u3057\u3044\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%83%AD%E3%83%BC%E3%83%AA%E3%83%B3%E3%82%B0%E3%82%B5%E3%83%BC%E3%82%AF%E3%83%AB%E5%A2%97%E5%B9%85%EF%BC%88RCA%EF%BC%9BRolling_Circle_Amplification%EF%BC%89\"><\/span><strong>\u30ed\u30fc\u30ea\u30f3\u30b0\u30b5\u30fc\u30af\u30eb\u5897\u5e45\uff08RCA\uff1bRolling Circle Amplification\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>RCA\u30d9\u30fc\u30b9\u306eNIPT\u306f\u3001\u7279\u5b9a\u306ecfDNA\u914d\u5217\u3092\u6a19\u7684\u3068\u3057\u3001\u305d\u308c\u3092\u591a\u6570\u30b3\u30d4\u30fc\u3059\u308b\u624b\u6cd5\u3092\u4f7f\u7528\u3057\u307e\u3059\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u3067\u306f\u3001\u7dda\u72b6DNA\u3092\u5186\u5f62\u306e\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8\u306b\u5909\u63db\u3057\u3001\u30ed\u30fc\u30ea\u30f3\u30b0\u30b5\u30fc\u30af\u30eb\u5897\u5e45\u3092\u884c\u3044\u3001\u6570\u5343\u3082\u306e\u30b3\u30d4\u30fc\u3092\u4f5c\u6210\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u5897\u5e45\u7523\u7269\u306f\u86cd\u5149\u8272\u7d20\u3067\u6a19\u8b58\u3055\u308c\u305f\u30ca\u30ce\u30dc\u30fc\u30eb\u3092\u5f62\u6210\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u86cd\u5149\u306e\u5f37\u5ea6\u306f\u57fa\u6e96\u30b5\u30f3\u30d7\u30eb\u3068\u6bd4\u8f03\u3057\u3066\u6e2c\u5b9a\u3055\u308c\u3001\u3042\u308b\u67d3\u8272\u4f53\u306e\u4fe1\u53f7\u304c\u671f\u5f85\u5024\u3088\u308a\u591a\u3044\u307e\u305f\u306f\u5c11\u306a\u3044\u5834\u5408\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>RCA\u306f\u901a\u5e38\u3001\u6a19\u7684\u578b\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u691c\u51fa\u306b\u7528\u3044\u3089\u308c\u3001\u5168\u30b2\u30ce\u30e0\u3067\u306f\u306a\u304f\u9650\u3089\u308c\u305f\u67d3\u8272\u4f53\u306b\u7126\u70b9\u3092\u5f53\u3066\u307e\u3059\u3002\u30b3\u30b9\u30c8\u52b9\u7387\u304c\u9ad8\u3044\u4e00\u65b9\u3067\u3001\u5305\u62ec\u6027\u306f\u9650\u5b9a\u7684\u3067\u3059\u3002<\/p>\n\n\n\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%83%9E%E3%82%A4%E3%82%AF%E3%83%AD%E3%82%A2%E3%83%AC%E3%82%A4%E3%83%99%E3%83%BC%E3%82%B9%E3%81%AE%E6%A4%9C%E6%9F%BB\"><\/span><strong>\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4\u30d9\u30fc\u30b9\u306e\u691c\u67fb<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u30d9\u30fc\u30b9\u306eNIPT\u3067\u306f\u3001\u77ed\u3044DNA\u914d\u5217\uff08\u30d7\u30ed\u30fc\u30d6\uff09\u304c\u591a\u6570\u914d\u7f6e\u3055\u308c\u305f\u56fa\u4f53\u8868\u9762\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u30c1\u30c3\u30d7\uff09\u3092\u4f7f\u7528\u3057\u307e\u3059\u3002\u5897\u5e45\u3055\u308c\u305f\u80ce\u76e4\u7531\u6765cfDNA\u306f\u86cd\u5149\u30bf\u30b0\u3067\u6a19\u8b58\u3055\u308c\u3001\u3053\u306e\u30a2\u30ec\u30a4\u306b\u9069\u7528\u3055\u308c\u307e\u3059\u3002cfDNA\u306e\u65ad\u7247\u304c\u30d7\u30ed\u30fc\u30d6\u3068\u4e00\u81f4\u3059\u308b\u3068\u3001\u305d\u3053\u306b\u7d50\u5408\uff08\u30cf\u30a4\u30d6\u30ea\u30c0\u30a4\u30ba\uff09\u3057\u3001\u767a\u5149\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5149\u306e\u5834\u6240\u3068\u5f37\u3055\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u3067\u3001\u5404\u67d3\u8272\u4f53\u304b\u3089\u3069\u308c\u3060\u3051\u306eDNA\u304c\u5b58\u5728\u3059\u308b\u304b\u3092\u89e3\u6790\u3057\u307e\u3059\u3002\u7279\u5b9a\u306e\u67d3\u8272\u4f53\u3067\u4fe1\u53f7\u304c\u7570\u5e38\u306b\u9ad8\u3044\u307e\u305f\u306f\u4f4e\u3044\u5834\u5408\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u30d9\u30fc\u30b9\u306eNIPT\u306f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\u306a\u3069\u306e\u4e00\u822c\u7684\u306a\u75be\u60a3\u306e\u691c\u51fa\u306b\u7279\u306b\u6709\u52b9\u3067\u3059\u304c\u3001\u3088\u308a\u7a00\u306a\u307e\u305f\u306f\u5fae\u7d30\u306a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306b\u5bfe\u3057\u3066\u306f\u611f\u5ea6\u304c\u52a3\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002RCA\u540c\u69d8\u3001<strong>\u6a19\u7684\u578b\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30d1\u30cd\u30eb<\/strong>\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002<\/p>\n\n\n\n\n\n\n<p><\/p>\n\n\n\n<style>\n  \/* <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> Table Styling *\/\n  .nipt-table {\n    margin: 0 auto;\n    max-width: 100%;\n  }\n\n  .nipt-table table {\n    width: 100%;\n    table-layout: fixed;\n    border-collapse: collapse;\n    margin: 0 auto;\n  }\n\n  .nipt-table th,\n  .nipt-table td {\n    padding: 12px 10px;\n    vertical-align: top;\n    border: 1px solid #ccc;\n    word-break: break-word;\n    font-weight: normal;\n  }\n\n  .nipt-table th {\n    background-color: #f5f5f5;\n    text-align: center;\n    font-weight: bold;\n  }\n\n  .nipt-table td {\n    text-align: left;\n  }\n\n  .nipt-table td .step {\n    margin-bottom: 8px;\n    line-height: 1.6;\n  }\n\n  \/* Mobile Responsive Stacking *\/\n  @media screen and (max-width: 768px) {\n    .nipt-table table,\n    .nipt-table thead,\n    .nipt-table tbody,\n    .nipt-table th,\n    .nipt-table td,\n    .nipt-table tr {\n      display: block;\n      width: 100%;\n    }\n\n    .nipt-table tr {\n      margin-bottom: 1em;\n    }\n\n    .nipt-table th {\n      position: absolute;\n      top: -9999px;\n      left: -9999px;\n    }\n\n    .nipt-table td {\n      border: none;\n      position: relative;\n      padding-left: 50%;\n      text-align: left !important;\n    }\n\n    .nipt-table td:before {\n      position: absolute;\n      left: 10px;\n      top: 12px;\n      white-space: nowrap;\n      font-weight: bold;\n    }\n\n    .nipt-table td:nth-of-type(1):before { content: \"\u624b\u6cd5\"; }\n    .nipt-table td:nth-of-type(2):before { content: \"\u540d\u79f0\"; }\n    .nipt-table td:nth-of-type(3):before { content: \"\u624b\u9806\"; }\n    .nipt-table td:nth-of-type(4):before { content: \"\u691c\u51fa\u65b9\u6cd5\"; }\n  }\n<\/style>\n\n\n\n<figure class=\"wp-block-table aligncenter nipt-table\">\n  <table>\n    <thead>\n      <tr>\n        <th style=\"width: 5%;\">\u624b\u6cd5<\/th>\n        <th style=\"width: 20%;\">\u540d\u79f0<\/th>\n        <th style=\"width: 40%;\">\u624b\u9806\uff08\u30b9\u30c6\u30c3\u30d7\u3054\u3068\u306e\u8aac\u660e\uff09<\/th>\n        <th style=\"width: 35%;\"><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\uff08\u7570\u6570\u6027\uff09\u306e\u691c\u51fa\u65b9\u6cd5<\/th>\n      <\/tr>\n    <\/thead>\n    <tbody>\n      <tr>\n        <td>\u2170<\/td>\n        <td>\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b7\u30fc\uff08WGS\uff09<\/td>\n        <td>\n          <div class=\"step\">1. \u6bcd\u4f53\u304b\u3089\u5c11\u91cf\u306e\u8840\u6db2\u3092\u63a1\u53d6\u3057\u307e\u3059\u3002\u3053\u306e\u8840\u6db2\u306b\u306f\u80ce\u76e4\u7531\u6765\u306e\u975e\u5e38\u306b\u5c0f\u3055\u306aDNA\u65ad\u7247\uff08cfDNA\uff09\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u901a\u5e38\u3053\u308c\u306f\u80ce\u5150\u306eDNA\u3068\u4e00\u81f4\u3057\u307e\u3059\u3002<\/div>\n          <div class=\"step\">2. \u3053\u308c\u3089\u306eDNA\u65ad\u7247\u306f\u3001DNA\u306e\u5869\u57fa\uff08A\u3001T\u3001G\u3001C\uff09\u3092\u8aad\u307f\u53d6\u308b\u5c02\u7528\u306e\u88c5\u7f6e\uff08\u30b7\u30fc\u30b1\u30f3\u30b5\u30fc\uff09\u3067\u8aad\u307f\u53d6\u3089\u308c\u307e\u3059\u3002<\/div>\n          <div class=\"step\">3. \u30b7\u30fc\u30b1\u30f3\u30b5\u30fc\u306f\u77ed\u3044DNA\u65ad\u7247\uff08\u30ea\u30fc\u30c9\uff09\u3092\u591a\u6570\u8aad\u307f\u53d6\u308a\u307e\u3059\u3002<\/div>\n          <div class=\"step\">4. \u3053\u308c\u3089\u306e\u30ea\u30fc\u30c9\u306f\u3001\u4eba\u9593\u306e\u5168\u30b2\u30ce\u30e0\u3068\u7167\u5408\u3055\u308c\u3001\u30d1\u30ba\u30eb\u306e\u30d4\u30fc\u30b9\u306e\u3088\u3046\u306b\u5168\u4f53\u50cf\u306b\u7d44\u307f\u8fbc\u307e\u308c\u307e\u3059\u3002<\/div>\n          <div class=\"step\">5. \u7d44\u307f\u7acb\u3066\u3089\u308c\u305fDNA\u304b\u3089\u3001\u5404\u65ad\u7247\u304c\u6bcd\u4f53\u7531\u6765\u304b\u80ce\u76e4\u7531\u6765\uff08\uff1d\u80ce\u5150\u7531\u6765\uff09\u304b\u3092\u7279\u5b9a\u3057\u307e\u3059\u3002<\/div>\n        <\/td>\n        <td>\n          \u79d1\u5b66\u8005\u305f\u3061\u306f\u3001\u5404\u67d3\u8272\u4f53\u304b\u3089\u5f97\u3089\u308c\u305fDNA\u91cf\u3092\u78ba\u8a8d\u3057\u307e\u3059\u3002\u3042\u308b\u67d3\u8272\u4f53\u306eDNA\u91cf\u304c\u901a\u5e38\u3088\u308a\u591a\u3059\u304e\u305f\u308a\u5c11\u306a\u3059\u304e\u305f\u308a\u3059\u308b\u3068\u3001\u4f59\u5206\u307e\u305f\u306f\u6b20\u640d\u3057\u3066\u3044\u308b\u67d3\u8272\u4f53\u304c\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u3053\u308c\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\uff08\u30c8\u30ea\u30bd\u30df\u30fc21\uff09\u306a\u3069\u306e\u72b6\u614b\u3092\u793a\u3059\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\n        <\/td>\n      <\/tr>\n      <tr>\n        <td>\u2171<\/td>\n        <td>SNP\u30d9\u30fc\u30b9\u306e\u691c\u67fb\uff08\u4e00\u5869\u57fa\u591a\u578b\uff09<\/td>\n        <td>\n          <div class=\"step\">1. \u6bcd\u4f53\u304b\u3089\u8840\u6db2\u3092\u63a1\u53d6\u3057\u3001\u6bcd\u4f53\u7531\u6765\u3068\u80ce\u76e4\u7531\u6765\u306ecfDNA\u3092\u5206\u96e2\u3057\u307e\u3059\u3002<\/div>\n          <div class=\"step\">2. \u691c\u67fb\u306fSNP\uff08\u4eba\u306b\u3088\u3063\u3066DNA\u5869\u57fa\u304c\u7570\u306a\u308b\u4f4d\u7f6e\uff09\u306b\u6ce8\u76ee\u3057\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u3042\u308b\u4f4d\u7f6e\u306b\u300cA\u300d\u3092\u6301\u3064\u4eba\u3082\u3044\u308c\u3070\u300cG\u300d\u3092\u6301\u3064\u4eba\u3082\u3044\u307e\u3059\u3002<\/div>\n          <div class=\"step\">3. PCR\uff08\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u9023\u9396\u53cd\u5fdc\uff09\u3068\u3044\u3046\u6280\u8853\u3092\u4f7f\u3063\u3066\u3001\u3053\u308c\u3089\u306e\u7279\u5b9a\u7b87\u6240\u3092\u591a\u6570\u30b3\u30d4\u30fc\u3057\u3001\u8a73\u7d30\u306b\u5206\u6790\u3067\u304d\u308b\u3088\u3046\u306b\u3057\u307e\u3059\u3002<\/div>\n          <div class=\"step\">4. \u6b21\u306b\u3001\u6bcd\u4f53\u3068\u80ce\u76e4DNA\u306e\u4e2d\u306b\u3042\u308b\u7570\u306a\u308b\u30a2\u30ec\u30eb\uff08\u907a\u4f1d\u5b50\u306e\u578b\uff09\u306e\u983b\u5ea6\u3092\u8aad\u307f\u53d6\u308a\u307e\u3059\u3002<\/div>\n          <div class=\"step\">5. \u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\u306e\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u304c\u3001\u6bcd\u4f53\u3068\u80ce\u76e4\u7531\u6765\u306e\u30a2\u30ec\u30eb\u306e\u6bd4\u7387\u3092\u6bd4\u8f03\u3057\u3001\u7570\u5e38\u304c\u306a\u3044\u304b\u3092\u78ba\u8a8d\u3057\u307e\u3059\u3002<\/div>\n        <\/td>\n        <td>\n          \u7279\u5b9a\u306eSNP\u3067\u30a2\u30ec\u30eb\u306e\u91cf\u306b\u504f\u308a\u304c\u898b\u3089\u308c\u308b\uff08\u591a\u3059\u304e\u305f\u308a\u5c11\u306a\u3059\u304e\u305f\u308a\u3059\u308b\uff09\u5834\u5408\u3001\u305d\u308c\u306f\u80ce\u5150\u306eDNA\u306b\u67d3\u8272\u4f53\u6570\u306e\u7570\u5e38\u304c\u3042\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u307e\u3059\u3002\u4f8b\u3048\u3070\u300118\u756a\u67d3\u8272\u4f53\u306e\u30b3\u30d4\u30fc\u6570\u304c\u591a\u3051\u308c\u3070\u3001\u30c8\u30ea\u30bd\u30df\u30fc18\uff08\u30a8\u30c9\u30ef\u30fc\u30ba\u75c7\u5019\u7fa4\uff09\u306e\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\n        <\/td>\n      <\/tr>\n      <tr>\n        <td>\u2172<\/td>\n        <td>\u30ed\u30fc\u30ea\u30f3\u30b0\u30b5\u30fc\u30af\u30eb\u5897\u5e45\uff08RCA\uff09<\/td>\n        <td>\n          <div class=\"step\">1. \u80ce\u76e4\u7531\u6765\u306ecfDNA\u3092\u5206\u96e2\u3057\u3001\u691c\u67fb\u5bfe\u8c61\u306e\u7279\u5b9a\u914d\u5217\u3092\u9078\u629e\u3057\u307e\u3059\u3002<\/div>\n          <div class=\"step\">2. \u7279\u6b8a\u306a\u30d7\u30ed\u30fc\u30d6\u3092\u4f7f\u3063\u3066\u3001\u9078\u3070\u308c\u305fDNA\u65ad\u7247\u3092\u5186\u5f62\u306b\u63a5\u7d9a\u3057\u307e\u3059\u3002<\/div>\n          <div class=\"step\">3. \u3053\u306e\u30eb\u30fc\u30d7\u72b6DNA\u306f\u3001\u7279\u5225\u306a\u9175\u7d20\u3068\u5316\u5b66\u7269\u8cea\u3068\u3068\u3082\u306b\u53cd\u5fdc\u3055\u305b\u3001\u7e70\u308a\u8fd4\u3057\u30b3\u30d4\u30fc\u3092\u4f5c\u308b\u300c\u30ed\u30fc\u30ea\u30f3\u30b0\u300d\u5897\u5e45\u3092\u884c\u3044\u307e\u3059\u3002<\/div>\n          <div class=\"step\">4. \u30b3\u30d4\u30fc\u3055\u308c\u305fDNA\u306f\u30ca\u30ce\u30dc\u30fc\u30eb\u3068\u3044\u3046\u5c0f\u3055\u306a\u69cb\u9020\u306b\u4e38\u307e\u308a\u3001\u305d\u308c\u305e\u308c\u86cd\u5149\u8272\u3067\u6a19\u8b58\u3055\u308c\u307e\u3059\u3002<\/div>\n          <div class=\"step\">5. \u6a5f\u68b0\u304c\u3001\u5404\u8272\u306e\u30ca\u30ce\u30dc\u30fc\u30eb\u306e\u6570\u3068\u86cd\u5149\u306e\u660e\u308b\u3055\u3092\u30ab\u30a6\u30f3\u30c8\u3057\u307e\u3059\u3002<\/div>\n        <\/td>\n        <td>\n          \u7279\u5b9a\u306e\u67d3\u8272\u4f53\u304b\u3089\u306e\u4fe1\u53f7\uff08\u86cd\u5149\uff09\u304c\u901a\u5e38\u3088\u308a\u660e\u308b\u3044\u307e\u305f\u306f\u6697\u3044\u5834\u5408\u3001\u305d\u308c\u306f\u80ce\u5150\u306b\u4f59\u5206\u307e\u305f\u306f\u6b20\u640d\u3057\u305f\u67d3\u8272\u4f53\u304c\u3042\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u300113\u756a\u67d3\u8272\u4f53\u306e\u4fe1\u53f7\u304c\u7570\u5e38\u306b\u660e\u308b\u3044\u5834\u5408\u3001\u30c8\u30ea\u30bd\u30df\u30fc13\uff08\u30d1\u30c8\u30a6\u75c7\u5019\u7fa4\uff09\u306e\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\n        <\/td>\n      <\/tr>\n      <tr>\n        <td>\u2173<\/td>\n        <td><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u89e3\u6790<\/td>\n        <td>\n          <div class=\"step\">1. \u80ce\u76e4\u7531\u6765\u306ecfDNA\u3092\u5897\u5e45\uff08\u30b3\u30d4\u30fc\uff09\u3057\u3001\u86cd\u5149\u30bf\u30b0\u3067\u6a19\u8b58\u3057\u307e\u3059\u3002<\/div>\n          <div class=\"step\">2. \u30c6\u30b9\u30c8\u306b\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u3068\u3044\u3046\u56fa\u4f53\u8868\u9762\u3092\u7528\u3044\u3001\u3053\u306e\u8868\u9762\u306b\u306f\u591a\u6570\u306e\u5408\u6210DNA\u65ad\u7247\uff08\u30d7\u30ed\u30fc\u30d6\uff09\u304c\u914d\u7f6e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5404\u30d7\u30ed\u30fc\u30d6\u306f\u7279\u5b9a\u306e\u67d3\u8272\u4f53\u914d\u5217\u3092\u8868\u3057\u307e\u3059\u3002<\/div>\n          <div class=\"step\">3. \u6a19\u8b58\u3055\u308c\u305fcfDNA\u3092<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u306b\u9069\u7528\u3059\u308b\u3068\u3001\u4e00\u81f4\u3059\u308bDNA\u306b\u7d50\u5408\uff08\u30cf\u30a4\u30d6\u30ea\u30c0\u30a4\u30ba\uff09\u3057\u307e\u3059\u3002<\/div>\n          <div class=\"step\">4. \u7d50\u5408\u304c\u8d77\u3053\u308b\u3068\u86cd\u5149\u30bf\u30b0\u304c\u5149\u308a\u307e\u3059\u3002<\/div>\n          <div class=\"step\">5. \u7279\u6b8a\u306a\u30ab\u30e1\u30e9\u304c\u305d\u306e\u5149\u4fe1\u53f7\u3092\u64ae\u5f71\u3057\u307e\u3059\u3002\u5149\u306e\u4f4d\u7f6e\u3068\u660e\u308b\u3055\u304b\u3089\u3001\u5404\u67d3\u8272\u4f53\u304b\u3089\u3069\u308c\u3060\u3051DNA\u304c\u7d50\u5408\u3057\u305f\u304b\u304c\u5206\u304b\u308a\u307e\u3059\u3002<\/div>\n        <\/td>\n        <td>\n          \u3042\u308b\u9818\u57df\u306e\u5149\u304c\u901a\u5e38\u3088\u308a\u660e\u308b\u3044\u307e\u305f\u306f\u6697\u3044\u5834\u5408\u3001\u305d\u308c\u306f\u305d\u306e\u67d3\u8272\u4f53\u306eDNA\u304c\u591a\u3059\u304e\u308b\u307e\u305f\u306f\u5c11\u306a\u3059\u304e\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u7570\u6570\u6027\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\uff09\u3092\u610f\u5473\u3057\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u300121\u756a\u67d3\u8272\u4f53\u306e\u5149\u304c\u7570\u5e38\u306b\u5f31\u3044\u5834\u5408\u300121\u756a\u67d3\u8272\u4f53\u306eDNA\u304c\u4e0d\u8db3\u3057\u3066\u3044\u308b\u30e2\u30ce\u30bd\u30df\u30fc21\u306e\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\n        <\/td>\n      <\/tr>\n    <\/tbody>\n  <\/table>\n<\/figure>\n\n\n\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%A6%AA%E3%81%AE%E3%81%9F%E3%82%81%E3%81%AENIPT%EF%BC%88%E9%9D%9E%E4%BE%B5%E8%A5%B2%E7%9A%84%E5%87%BA%E7%94%9F%E5%89%8D%E8%A8%BA%E6%96%AD%EF%BC%89%E6%8A%80%E8%A1%93\"><\/span><strong>\u89aa\u306e\u305f\u3081\u306eNIPT\uff08\u975e\u4fb5\u8972\u7684\u51fa\u751f\u524d\u8a3a\u65ad\uff09\u6280\u8853<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"NIPT%E6%A4%9C%E6%9F%BB%E3%81%AF%E3%81%99%E3%81%B9%E3%81%A6%E5%90%8C%E3%81%98%E7%96%BE%E6%82%A3%E3%82%92%E8%AA%BF%E3%81%B9%E3%82%8B%E3%82%8F%E3%81%91%E3%81%A7%E3%81%AF%E3%81%82%E3%82%8A%E3%81%BE%E3%81%9B%E3%82%93\"><\/span><strong>NIPT\u691c\u67fb\u306f\u3059\u3079\u3066\u540c\u3058\u75be\u60a3\u3092\u8abf\u3079\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>NIPT\u306e\u691c\u67fb\u9805\u76ee\u306f\u3059\u3079\u3066\u540c\u3058\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u4e00\u90e8\u306e\u691c\u67fb\u306f\u300c\u30bf\u30fc\u30b2\u30c3\u30c8\u578b\u300d\u3067\u3042\u308a\u3001\u5168\u30b2\u30ce\u30e0\u3092\u8abf\u3079\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u7684\u5909\u5316\u3084\u95a2\u5fc3\u306e\u3042\u308b\u9818\u57df\u306b\u7126\u70b9\u3092\u5f53\u3066\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u691c\u67fb\u306f\u3001\u5bb6\u65cf\u306b\u7279\u5b9a\u306e\u907a\u4f1d\u6027\u75be\u60a3\u306e\u65e2\u5f80\u6b74\u304c\u3042\u308b\u5834\u5408\u306b\u7279\u306b\u6709\u7528\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001\u89aa\u3084\u8fd1\u3044\u5bb6\u65cf\u306b\u65e2\u77e5\u306e\u907a\u4f1d\u6027\u75be\u60a3\u304c\u3042\u308b\u5834\u5408\u3001\u533b\u5e2b\u304c\u305d\u306e\u75be\u60a3\u306b\u95a2\u9023\u3059\u308bDNA\u9818\u57df\u3092\u7279\u5b9a\u7684\u306b\u8abf\u3079\u308b\u30bf\u30fc\u30b2\u30c3\u30c8\u578bNIPT\u3092\u52e7\u3081\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u30b1\u30fc\u30b9\u3067\u306f\u3001NIPT\u306f\u6709\u76ca\u306a\u60c5\u5831\u3084\u5b89\u5fc3\u611f\u3092\u3082\u305f\u3089\u3057\u3001\u3055\u3089\u306a\u308b\u691c\u67fb\u304c\u5fc5\u8981\u304b\u3069\u3046\u304b\u306e\u5224\u65ad\u6750\u6599\u306b\u3082\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001NIPT\u306f\u80ce\u5150\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3059\u308b\u305f\u3081\u306b\u8a2d\u8a08\u3055\u308c\u305f\u691c\u67fb\u3067\u3042\u308a\u3001\u80ce\u76e4\u7531\u6765\u306ecfDNA\uff08\u904a\u96e2DNA\uff09\u3092\u5206\u6790\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u89aa\u306eDNA\u81ea\u4f53\u3092\u8abf\u3079\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u89aa\u304c\u907a\u4f1d\u6027\u75be\u60a3\u306e\u4fdd\u56e0\u8005\u3067\u3042\u308b\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u308b\u76ee\u7684\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u91cd\u7be4\u306a\u907a\u4f1d\u6027\u75be\u60a3\u306e\u4e2d\u306b\u306f\u3001\u7236\u6bcd\u306e\u4e21\u65b9\u304b\u3089\u6f5c\u6027\u907a\u4f1d\u5b50\u306e\u75c5\u7684\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u53d7\u3051\u53d6\u3063\u305f\u5834\u5408\u306b\u767a\u75c7\u3059\u308b\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306a\u5834\u5408\u306b\u884c\u3046\u691c\u67fb\u306f\u30ad\u30e3\u30ea\u30a2\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\uff08\u4fdd\u56e0\u8005\u691c\u67fb\uff09\u3068\u547c\u3070\u308c\u3001NIPT\u3068\u306f\u5225\u7269\u3067\u3059\u3002\u30ad\u30e3\u30ea\u30a2\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306f\u901a\u5e38\u3001\u598a\u5a20\u524d\u3084\u598a\u5a20\u521d\u671f\u306b\u3001\u89aa\u306e\u3044\u305a\u308c\u304b\u307e\u305f\u306f\u4e21\u65b9\u306e\u8840\u6db2\u307e\u305f\u306f\u553e\u6db2\u30b5\u30f3\u30d7\u30eb\u304b\u3089\u884c\u308f\u308c\u307e\u3059\u3002\u8fd1\u5e74\u3067\u306f\u3001\u53e3\u8154\u7c98\u819c\uff08\u982c\u306e\u5185\u5074\uff09\u3092\u7dbf\u68d2\u3067\u63a1\u53d6\u3059\u308b\u3060\u3051\u3067\u7c21\u5358\u304b\u3064\u7121\u75db\u3067\u5b9f\u65bd\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u30ad\u30e3\u30ea\u30a2\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3068\u306f\u3001\u89aa\u304c\u8d64\u3061\u3083\u3093\u306b\u907a\u4f1d\u3059\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u907a\u4f1d\u5b50\u5909\u7570\u3092\u4fdd\u6709\u3057\u3066\u3044\u308b\u304b\u3092\u8abf\u3079\u308b\u691c\u67fb\u3067\u3059\u3002NIPT\u3068\u306f\u5225\u306e\u691c\u67fb\u3067\u3042\u308a\u3001NIPT\u306b\u306f\u542b\u307e\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%AE%9F%E7%94%A8%E7%9A%84%E3%81%AA%E9%81%95%E3%81%84%E3%82%82%E8%80%83%E6%85%AE%E3%81%99%E3%81%B9%E3%81%8D%E3%83%9D%E3%82%A4%E3%83%B3%E3%83%88\"><\/span><strong>\u5b9f\u7528\u7684\u306a\u9055\u3044\u3082\u8003\u616e\u3059\u3079\u304d\u30dd\u30a4\u30f3\u30c8<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u691c\u67fb\u304c\u5bfe\u8c61\u3068\u3059\u308b\u75be\u60a3\u5185\u5bb9\u4ee5\u5916\u306b\u3082\u3001NIPT\u306b\u306f\u5b9f\u7528\u7684\u306a\u9055\u3044\u304c\u3044\u304f\u3064\u304b\u3042\u308a\u307e\u3059\u3002\u4ee5\u4e0b\u306f\u305d\u306e\u4ee3\u8868\u4f8b\u3067\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7d50\u679c\u306e\u8fd4\u5374\u6642\u9593\uff08\u30bf\u30fc\u30f3\u30a2\u30e9\u30a6\u30f3\u30c9\u30bf\u30a4\u30e0\uff09\u306f\u691c\u67fb\u6cd5\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002\u6570\u55b6\u696d\u65e5\u3067\u7d50\u679c\u304c\u51fa\u308b\u691c\u67fb\u3082\u3042\u308c\u3070\u30012\u9031\u9593\u7a0b\u5ea6\u304b\u304b\u308b\u3082\u306e\u3082\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u4f7f\u7528\u3055\u308c\u308b\u624b\u6cd5\u3001\u5206\u6790\u306e\u8907\u96d1\u3055\u3001\u691c\u67fb\u3092\u884c\u3046\u30e9\u30dc\u306b\u3088\u3063\u3066\u5de6\u53f3\u3055\u308c\u307e\u3059\u3002<br><\/li>\n\n\n\n<li>\u8cbb\u7528\u3082\u5927\u5207\u306a\u8981\u7d20\u3067\u3059\u3002RCA\u306e\u3088\u3046\u306a\u7c21\u6613\u306a\u6280\u8853\u3092\u4f7f\u3063\u305fNIPT\u306f\u6bd4\u8f03\u7684\u5b89\u4fa1\u3067\u3059\u304c\u3001WGS\u306e\u3088\u3046\u306a\u3088\u308a\u9ad8\u5ea6\u306a\u6280\u8853\u3092\u4f7f\u7528\u3059\u308b\u691c\u67fb\u306f\u3001\u5168\u30b2\u30ce\u30e0\u306e\u5e83\u7bc4\u56f2\u3092\u8abf\u3079\u308b\u305f\u3081\u3001\u4e00\u822c\u7684\u306b\u9ad8\u984d\u3067\u3059\u3002<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p>\u3068\u306f\u3044\u3048\u30012025\u5e74\u73fe\u5728\u3001\u3059\u3079\u3066\u306eNIPT\u6280\u8853\u306f\u9032\u5316\u3092\u7d9a\u3051\u3066\u304a\u308a\u3001\u30b3\u30b9\u30c8\u306f\u4f4e\u4e0b\u3057\u3001\u7d50\u679c\u306f\u3088\u308a\u8fc5\u901f\u306b\u8fd4\u3055\u308c\u3001\u691c\u67fb\u306e\u9078\u629e\u80a2\u3082\u62e1\u5927\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001NIPT\u306f\u304b\u3064\u3066\u306a\u3044\u307b\u3069\u5229\u7528\u3057\u3084\u3059\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_%E9%99%BD%E6%80%A7%E7%B5%90%E6%9E%9C%E3%81%8C%E5%87%BA%E3%81%9F%E5%A0%B4%E5%90%88%E3%82%82%E3%80%81%E5%BF%85%E3%81%9A%E7%A2%BA%E5%AE%9A%E6%A4%9C%E6%9F%BB%E3%81%8C%E5%BF%85%E8%A6%81%E3%81%A7%E3%81%99\"><\/span><strong>3. \u967d\u6027\u7d50\u679c\u304c\u51fa\u305f\u5834\u5408\u3082\u3001\u5fc5\u305a\u78ba\u5b9a\u691c\u67fb\u304c\u5fc5\u8981\u3067\u3059<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>NIPT\u306e\u7d50\u679c\u304c\u300c\u967d\u6027\u300d\u3067\u8fd4\u3063\u3066\u304d\u305f\u5834\u5408\u2014\u3064\u307e\u308a\u3001\u8d64\u3061\u3083\u3093\u306b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\u306a\u3069\uff09\u304c\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u305f\u5834\u5408\u3067\u3082\u3001\u305d\u308c\u304c\u78ba\u5b9f\u306b\u305d\u306e\u75be\u60a3\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u610f\u5473\u3059\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>NIPT\u306f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u691c\u67fb\u3067\u3042\u308a\u3001\u8a3a\u65ad\u691c\u67fb\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u6280\u8853\u306f\u5e74\u3005\u9032\u5316\u3057\u3066\u3044\u307e\u3059\u304c\u3001NIPT\u306f\u3042\u304f\u307e\u3067\u75be\u60a3\u306e\u300c\u53ef\u80fd\u6027\u300d\u3092\u8a55\u4fa1\u3059\u308b\u691c\u67fb\u3067\u3059\u3002\u3069\u308c\u3060\u3051\u9ad8\u7cbe\u5ea6\u3067\u3082\u3001\u307e\u308c\u306b\u8aa4\u3063\u305f\u7d50\u679c\uff08\u507d\u967d\u6027\u3084\u507d\u9670\u6027\uff09\u304c\u51fa\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3057\u305f\u304c\u3063\u3066\u3001\u967d\u6027\u7d50\u679c\u304c\u51fa\u305f\u5834\u5408\u306f\u3001\u5fc5\u305a\u78ba\u5b9a\u8a3a\u65ad\u3092\u884c\u3046\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u78ba\u5b9a\u691c\u67fb\u306b\u306f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-clinic\/amniocentesis\/\">\u7f8a\u6c34\u691c\u67fb<\/a>\u3084<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chorionic-villus-test\/\">\u7d68\u6bdb\u691c\u67fb<\/a>\uff08CVS\uff09\u306a\u3069\u304c\u3042\u308a\u3001\u80ce\u5150\u306e\u67d3\u8272\u4f53\u3092\u76f4\u63a5\u8abf\u3079\u308b\u305f\u3081\u3001\u3088\u308a\u78ba\u5b9f\u306a\u60c5\u5831\u304c\u5f97\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u91cd\u8981\u306a\u5224\u65ad\u3092\u3059\u308b\u524d\u306b\u3001\u3053\u308c\u3089\u306e\u78ba\u5b9a\u691c\u67fb\u3092\u53d7\u3051\u3001\u533b\u5e2b\u3084\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30e9\u30fc\u3068\u76f8\u8ac7\u3057\u306a\u304c\u3089\u3001\u7d50\u679c\u306e\u610f\u5473\u3084\u4eca\u5f8c\u306e\u9078\u629e\u80a2\u306b\u3064\u3044\u3066\u7406\u89e3\u3092\u6df1\u3081\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n\n\n\n    <a href=\"\/nipt\/follow-up-after-inspection\/\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">\u3082\u3057NIPT\u304c\u967d\u6027\u3060\u3063\u305f\u3089\uff1f\u691c\u67fb\u5f8c\u306f\u3069\u3046\u3059\u308c\u3070\u826f\u3044\u304b\u89e3\u8aac\u3010\u533b\u5e2b\u76e3\u4fee\u3011 <\/div>\n          <div class=\"blog-card-excerpt\">NIPT(\u65b0\u578b\u51fa\u751f\u524d\u8a3a\u65ad)\u3092\u53d7\u691c\u3057\u3066\u3001\u3082\u3057\u967d\u6027\u3060\u3063\u305f\u3089\u3069\u3046\u3057\u307e\u3059\u304b\uff1fNIPT\u306f\u53d7\u691c\u3057\u305f\u5f8c\u306e\u7d50\u679c\u3092\u53d7\u3051\u3066\u3069\u306e\u3088\u3046\u306a\u30a2\u30d5\u30bf\u30fc\u30d5\u30a9\u30ed\u30fc\u304c\u3042\u308b\u304b\u3001\u307e...<\/div>\n      <\/div>\n    <\/a>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4_NIPT%E3%81%AF%E5%AE%89%E5%85%A8%E3%81%A7%E9%9D%9E%E4%BE%B5%E8%A5%B2%E7%9A%84%E3%81%A7%E3%81%99\"><\/span><strong>4. NIPT\u306f\u5b89\u5168\u3067\u975e\u4fb5\u8972\u7684\u3067\u3059<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>NIPT\u306f\u3001\u6bcd\u4f53\u304b\u3089\u306e\u63a1\u8840\u306b\u3088\u3063\u3066\u884c\u308f\u308c\u308b\u7c21\u5358\u306a\u691c\u67fb\u3067\u3059\u3002\u80ce\u5150\u306b\u5bfe\u3059\u308b\u30ea\u30b9\u30af\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3053\u308c\u306f\u3001\u80ce\u76e4\u304b\u3089\u6bcd\u4f53\u306e\u8840\u6db2\u4e2d\u306b\u81ea\u7136\u306b\u6d41\u308c\u8fbc\u3093\u3067\u3044\u308bcfDNA\uff08\u904a\u96e2DNA\uff09\u3092\u5206\u6790\u3059\u308b\u3053\u3068\u3067\u884c\u308f\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u901a\u5e38\u3001\u598a\u5a2010\u9031\u9803\u304b\u3089\u691c\u67fb\u304c\u53ef\u80fd\u3067\u3059\u304c\u3001\u91cd\u8981\u306a\u306e\u306f\u9031\u6570\u3088\u308a\u3082\u3001\u80ce\u76e4\uff08\uff1d\u80ce\u5150\uff09\u304c\u5341\u5206\u306b\u767a\u9054\u3057\u3001\u6bcd\u4f53\u306e\u8840\u4e2d\u306b\u5341\u5206\u306a\u91cf\u306ecfDNA\u304c\u653e\u51fa\u3055\u308c\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306ecfDNA\u306e\u5272\u5408\u306f\u80ce\u5150\u7531\u6765\u5272\u5408\uff08fetal fraction\uff09\u3068\u547c\u3070\u308c\u3001\u691c\u67fb\u7d50\u679c\u306e\u4fe1\u983c\u6027\u306b\u76f4\u7d50\u3057\u307e\u3059\u3002\u80ce\u5150DNA\u304c\u5c11\u306a\u3059\u304e\u308b\u3068\u3001\u691c\u67fb\u304c\u5224\u5b9a\u4e0d\u80fd\uff08inconclusive\uff09\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u5834\u5408\u306f\u3001\u6570\u9031\u9593\u5f8c\u306b\u518d\u691c\u67fb\u304c\u5fc5\u8981\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u9069\u5207\u306a\u691c\u67fb\u6642\u671f\u306b\u3064\u3044\u3066\u306f\u3001\u598a\u5a20\u9031\u6570\u3084\u4f53\u8cea\u3092\u8e0f\u307e\u3048\u3066\u3001\u533b\u7642\u63d0\u4f9b\u8005\u304c\u6700\u9069\u306a\u30bf\u30a4\u30df\u30f3\u30b0\u3092\u5224\u65ad\u3057\u3066\u304f\u308c\u307e\u3059\u3002<\/p>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"5_%E8%B6%85%E9%9F%B3%E6%B3%A2%E6%A4%9C%E6%9F%BB%E3%82%82%E4%BE%9D%E7%84%B6%E3%81%A8%E3%81%97%E3%81%A6%E5%BF%85%E8%A6%81%E3%81%A7%E3%81%99\"><\/span><strong>5. \u8d85\u97f3\u6ce2\u691c\u67fb\u3082\u4f9d\u7136\u3068\u3057\u3066\u5fc5\u8981\u3067\u3059<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>NIPT\u306f\u5f37\u529b\u306a\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u624b\u6bb5\u3067\u3059\u304c\u3001\u3059\u3079\u3066\u306e\u7570\u5e38\u3092\u691c\u51fa\u3067\u304d\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u4e3b\u306b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\u306a\u3069\uff09\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u304a\u308a\u3001\u8eab\u4f53\u7684\u30fb\u69cb\u9020\u7684\u306a\u7570\u5e38\u3084\u307e\u308c\u306a\u907a\u4f1d\u75be\u60a3\u307e\u3067\u306f\u30ab\u30d0\u30fc\u3057\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u305d\u306e\u305f\u3081\u3001NIPT\u306f\u598a\u5a20\u4e2d\u306e\u8d85\u97f3\u6ce2\u691c\u67fb\u3068\u4f75\u7528\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8d85\u97f3\u6ce2\u306f\u3001\u80ce\u5150\u306e\u8eab\u4f53\u7684\u767a\u9054\u306e\u69d8\u5b50\u3092\u6620\u50cf\u3068\u3057\u3066\u78ba\u8a8d\u3067\u304d\u3001NIPT\u3067\u306f\u5206\u304b\u3089\u306a\u3044\u5fc3\u81d3\u3001\u8133\u3001\u810a\u690e\u306a\u3069\u306e\u69cb\u9020\u7570\u5e38\u3092\u767a\u898b\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u80ce\u5150\u6570\uff08\u53cc\u5b50\u306a\u3069\uff09\u306e\u78ba\u8a8d\u3084\u3001\u80ce\u5150\u306e\u767a\u80b2\u72b6\u614b\u3001NIPT\u306e\u691c\u67fb\u5bfe\u8c61\u5916\u306e\u75be\u60a3\u306e\u5146\u5019\u3092\u898b\u3064\u3051\u308b\u306e\u306b\u3082\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n\n\n\n<p>NIPT\u3068\u8d85\u97f3\u6ce2\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u5305\u62ec\u7684\u306a\u598a\u5a20\u4e2d\u306e\u5065\u5eb7\u8a55\u4fa1\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"6_NIPT%E3%81%AE%E3%83%96%E3%83%A9%E3%83%B3%E3%83%89%E3%81%AB%E3%81%AF%E9%81%95%E3%81%84%E3%81%8C%E3%81%82%E3%82%8A%E3%81%BE%E3%81%99\"><\/span><strong>6. NIPT\u306e\u30d6\u30e9\u30f3\u30c9\u306b\u306f\u9055\u3044\u304c\u3042\u308a\u307e\u3059<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u5e02\u8ca9\u3055\u308c\u3066\u3044\u308bNIPT\u306b\u306f\u3001\u4f7f\u7528\u3057\u3066\u3044\u308b\u6280\u8853\u3084\u7cbe\u5ea6\u306b\u5fae\u5999\u306a\u304c\u3089\u91cd\u8981\u306a\u9055\u3044\u304c\u3042\u308a\u307e\u3059\u3002\u5404\u793e\u306f\u82e5\u5e72\u7570\u306a\u308bDNA\u5206\u6790\u624b\u6cd5\u3092\u7528\u3044\u3066\u304a\u308a\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u691c\u51fa\u3067\u304d\u308b\u75be\u60a3\u306e\u7a2e\u985e\u3001\u7cbe\u5ea6\u3001\u518d\u691c\u67fb\u306e\u5fc5\u8981\u6027\u306a\u3069\u306b\u5dee\u304c\u751f\u3058\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u591a\u304f\u306e\u8a8d\u53ef\u3055\u308c\u305fNIPT\u306f\u9ad8\u7cbe\u5ea6\u3067\u3059\u304c\u3001\u691c\u67fb\u5185\u5bb9\u306e\u8a73\u7d30\u306f\u7570\u306a\u308a\u307e\u3059\u3002<br>\u305d\u306e\u305f\u3081\u3001\u4f7f\u7528\u3059\u308bNIPT\u306e\u7a2e\u985e\u3001\u5bfe\u8c61\u75be\u60a3\u3001\u7cbe\u5ea6\u3001\u63a8\u5968\u7406\u7531\u306b\u3064\u3044\u3066\u533b\u5e2b\u3084\u52a9\u7523\u5e2b\u306b\u78ba\u8a8d\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002\u81ea\u5206\u306e\u598a\u5a20\u72b6\u6cc1\u306b\u6700\u3082\u9069\u3057\u305f\u691c\u67fb\u3092\u9078\u3076\u305f\u3081\u306e\u5224\u65ad\u6750\u6599\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%81%93%E3%81%AE%E6%83%85%E5%A0%B1%E3%82%92%E3%81%A9%E3%81%86%E6%B4%BB%E7%94%A8%E3%81%99%E3%81%B9%E3%81%8D%E3%81%8B%EF%BC%9F\"><\/span><strong>\u3053\u306e\u60c5\u5831\u3092\u3069\u3046\u6d3b\u7528\u3059\u3079\u304d\u304b\uff1f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u598a\u5a20\u4e2d\u3001\u307e\u305f\u306f\u598a\u5a20\u3092\u4e88\u5b9a\u3057\u3066\u3044\u308b\u65b9\u306f\u3001NIPT\u304c\u81ea\u5206\u306b\u9069\u3057\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u3092\u533b\u7642\u6a5f\u95a2\u3067\u76f8\u8ac7\u3059\u308b\u3053\u3068\u3092\u304a\u52e7\u3081\u3057\u307e\u3059\u3002\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u8cea\u554f\u3092\u533b\u5e2b\u306b\u3057\u3066\u307f\u307e\u3057\u3087\u3046\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>NIPT\u306f\u79c1\u3084\u79c1\u306e\u598a\u5a20\u306b\u3068\u3063\u3066\u9069\u5207\u3067\u3059\u304b\uff1f<br><\/li>\n\n\n\n<li>\u3069\u306e\u30bf\u30a4\u30d7\u306eNIPT\u3092\u4f7f\u7528\u3057\u3066\u3044\u307e\u3059\u304b\uff1f\u305d\u308c\u306f\u4f55\u3092\u691c\u67fb\u3057\u307e\u3059\u304b\uff1f<br><\/li>\n\n\n\n<li>\u691c\u67fb\u7d50\u679c\u304c\u967d\u6027\u3060\u3063\u305f\u5834\u5408\u3001\u6b21\u306b\u4f55\u304c\u8d77\u3053\u308a\u307e\u3059\u304b\uff1f<br><\/li>\n\n\n\n<li>\u79c1\u306e\u5730\u57df\u3067\u306fNIPT\u306f\u4fdd\u967a\u3084\u516c\u7684\u533b\u7642\u5236\u5ea6\u306e\u5bfe\u8c61\u3067\u3059\u304b\uff1f<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u8cea\u554f\u3092\u3059\u308b\u3053\u3068\u3067\u3001\u81ea\u5206\u306e\u72b6\u6cc1\u306b\u5408\u3063\u305f\u9069\u5207\u306a\u5224\u65ad\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n    <a href=\"\/nipt\/early-pregnancy\/\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">PMS\u3068\u598a\u5a20\u521d\u671f\u75c7\u72b6\u306e\u9055\u3044\u3068\u306f\uff1f\u598a\u5a20\u521d\u671f\u306e\u904e\u3054\u3057\u65b9\u3010\u533b\u5e2b\u76e3\u4fee\u3011 <\/div>\n          <div class=\"blog-card-excerpt\">\u598a\u5a20\u306b\u3088\u3063\u3066\u4f53\u5185\u3067\u306f\u5927\u304d\u306a\u5909\u5316\u304c\u8d77\u3053\u308a\u307e\u3059\u3002\u598a\u5a20\u521d\u671f\u306f\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306e\u6025\u6fc0\u306a\u5909\u5316\u306b\u598a\u5a66\u3055\u3093\u306e\u5fc3\u3068\u8eab\u4f53\u306f\u3086\u3089\u304e\u3001\u30a4\u30e9\u30a4\u30e9\u3084\u4e0d\u5b89\u306a\u3069\u3092\u62b1\u3048\u308b\u65b9...<\/div>\n      <\/div>\n    <\/a>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%BC%95%E7%94%A8%E6%96%87%E7%8C%AE_References\"><\/span><strong>\u5f15\u7528\u6587\u732e References<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.3390\/jcm14082813\">Marton, Tamas, et al. \u2018Systematic Review of Accuracy Differences in NIPT Methods for Common Aneuploidy Screening\u2019. Journal of Clinical Medicine, vol. 14, no. 8, Apr. 2025, p. 2813. DOI.org (Crossref), https:\/\/doi.org\/10.3390\/jcm14082813.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1002\/pd.5989\">Benn, Peter, and Andrei Rebarber. \u2018Non\u2010invasive Prenatal Testing in the Management of Twin Pregnancies\u2019. Prenatal Diagnosis, vol. 41, no. 10, Sept. 2021, pp. 1233\u201340. DOI.org (Crossref), https:\/\/doi.org\/10.1002\/pd.5989.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.ajog.2023.11.890\">Quintero, Ruben A., et al. \u2018866 Zygosity-Based Twin Pregnancy Outcomes: Insights from SNP-Based cfDNA Screening\u2019. American Journal of Obstetrics and Gynecology, vol. 230, no. 1, Jan. 2024, p. S459. DOI.org (Crossref), https:\/\/doi.org\/10.1016\/j.ajog.2023.11.890.<\/a><\/li>\n<\/ul>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading custom-heading2\"><span class=\"ez-toc-section\" id=\"%E3%80%90%E8%A9%B3%E7%B4%B0%E8%A7%A3%E8%AA%AC%E3%80%91%E4%B8%80%E8%88%AC%E7%9A%84%E3%81%AA%E5%B8%B8%E6%9F%93%E8%89%B2%E4%BD%93%E7%95%B0%E6%95%B0%E6%80%A7%E3%82%B9%E3%82%AF%E3%83%AA%E3%83%BC%E3%83%8B%E3%83%B3%E3%82%B0%E3%81%AB%E3%81%8A%E3%81%91%E3%82%8BNIPT%E6%89%8B%E6%B3%95%E3%81%AE%E7%B2%BE%E5%BA%A6%E5%B7%AE%E3%81%AB%E9%96%A2%E3%81%99%E3%82%8B%E4%BD%93%E7%B3%BB%E7%9A%84%E3%83%AC%E3%83%93%E3%83%A5%E3%83%BC\"><\/span>\u3010\u8a73\u7d30\u89e3\u8aac\u3011\u4e00\u822c\u7684\u306a\u5e38\u67d3\u8272\u4f53\u7570\u6570\u6027\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u304a\u3051\u308bNIPT\u624b\u6cd5\u306e\u7cbe\u5ea6\u5dee\u306b\u95a2\u3059\u308b\u4f53\u7cfb\u7684\u30ec\u30d3\u30e5\u30fc<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"has-text-align-center\"><a href=\"https:\/\/doi.org\/10.3390\/jcm14082813\"><strong>Marton, Tamas, et al. \u2018Systematic Review of Accuracy Differences in NIPT Methods for Common Aneuploidy Screening\u2019. Journal of Clinical Medicine, vol. 14, no. 8, Apr. 2025, p. 2813. DOI.org (Crossref), https:\/\/doi.org\/10.3390\/jcm14082813.<\/strong><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%A6%82%E8%A6%81\"><\/span><strong>\u6982\u8981<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u672c\u4f53\u7cfb\u7684\u30ec\u30d3\u30e5\u30fc\u306f\u3001\u975e\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>\uff09\u306b\u304a\u3044\u3066\u80ce\u5150\u306e\u4e00\u822c\u7684\u306a\u5e38\u67d3\u8272\u4f53\u7570\u6570\u6027\u2014\u5177\u4f53\u7684\u306b\u306f\u30c8\u30ea\u30bd\u30df\u30fc21\uff08T21\uff09\u3001\u30c8\u30ea\u30bd\u30df\u30fc18\uff08T18\uff09\u3001\u30c8\u30ea\u30bd\u30df\u30fc13\uff08T13\uff09\u2014\u306e\u691c\u51fa\u3092\u76ee\u7684\u3068\u3057\u305f4\u3064\u306e\u4e3b\u8981\u624b\u6cd5\u306e\u8a3a\u65ad\u6027\u80fd\u3092\u6279\u5224\u7684\u306b\u691c\u8a0e\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u8a55\u4fa1\u5bfe\u8c61\u306e\u624b\u6cd5\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3042\u308b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\uff08WGS\uff09<\/li>\n\n\n\n<li>\u4e00\u5869\u57fa\u591a\u578b\uff08SNP\uff09\u306b\u57fa\u3065\u304f\u30a2\u30c3\u30bb\u30a4<\/li>\n\n\n\n<li><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u306b\u3088\u308b\u691c\u51fa<\/li>\n\n\n\n<li>\u30ed\u30fc\u30ea\u30f3\u30b0\u30b5\u30fc\u30af\u30eb\u5897\u5e45\u6cd5\uff08RCA\uff09<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p>\u672c\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u30012003\u5e74\u304b\u30892023\u5e74\u306e\u9593\u306b\u767a\u8868\u3055\u308c\u305f21\u4ef6\u306e\u7814\u7a76\u304b\u3089\u306a\u308b\u8a0892,164\u4f8b\u306e\u598a\u5a66\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3057\u3066\u3044\u308b\u3002\u5404\u7814\u7a76\u306f\u3001\u771f\u967d\u6027\uff08TP\uff09\u3001\u507d\u967d\u6027\uff08FP\uff09\u3001\u507d\u9670\u6027\uff08FN\uff09\u3001\u771f\u9670\u6027\uff08TN\uff09\u306b\u57fa\u3065\u304f\u611f\u5ea6\u3001\u7279\u7570\u5ea6\u3001\u967d\u6027\u7684\u4e2d\u7387\uff08PPV\uff09\u3001\u9670\u6027\u7684\u4e2d\u7387\uff08NPV\uff09\u3068\u3044\u3063\u305f\u4e3b\u8981\u306a\u8a3a\u65ad\u6307\u6a19\u3092\u5831\u544a\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_%E8%83%8C%E6%99%AF%E3%81%A8%E6%A0%B9%E6%8B%A0\"><\/span><strong>1. \u80cc\u666f\u3068\u6839\u62e0<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%83%88%E3%83%AA%E3%82%BD%E3%83%9F%E3%83%BC%E6%A4%9C%E5%87%BA%E3%81%AE%E8%87%A8%E5%BA%8A%E7%9A%84%E9%87%8D%E8%A6%81%E6%80%A7\"><\/span><strong>\u30c8\u30ea\u30bd\u30df\u30fc\u691c\u51fa\u306e\u81e8\u5e8a\u7684\u91cd\u8981\u6027<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>T21\u3001T18\u3001T13\u306f\u51fa\u751f\u5150\u306b\u6700\u3082\u591a\u304f\u898b\u3089\u308c\u308b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3067\u3042\u308a\u3001\u767a\u9054\u969c\u5bb3\u3084\u8eab\u4f53\u7684\u75be\u60a3\u306e\u4e3b\u8981\u56e0\u3067\u3042\u308b\u3002\u65e9\u671f\u304b\u3064\u6b63\u78ba\u306a\u691c\u51fa\u306f\u3001\u598a\u5a20\u7ba1\u7406\u3084\u81e8\u5e8a\u8ee2\u5e30\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"NIPT%E6%8A%80%E8%A1%93%E3%81%AE%E6%A6%82%E8%A6%81\"><\/span><strong>NIPT\u6280\u8853\u306e\u6982\u8981<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u3059\u3079\u3066\u306eNIPT\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306f\u3001\u6bcd\u4f53\u8840\u6f3f\u4e2d\u3092\u5faa\u74b0\u3059\u308b\u80ce\u5150\u7531\u6765\u306e\u30bb\u30eb\u30d5\u30ea\u30fcDNA\uff08cfDNA\uff09\u3092\u691c\u51fa\u5bfe\u8c61\u3068\u3059\u308b\u3002\u3053\u306ecfDNA\u306f\u4e3b\u306b\u80ce\u76e4\u306e\u6804\u990a\u819c\u7d30\u80de\u7531\u6765\u3067\u3042\u308b\u3002NIPT\u306f\u975e\u4fb5\u8972\u7684\u3067\u3001\u598a\u5a2010\u9031\u76ee\u4ee5\u964d\u306b\u5b9f\u65bd\u53ef\u80fd\u3067\u3042\u308a\u3001\u5f93\u6765\u6cd5\uff08\u4f8b\uff1a\u6bcd\u4f53\u8840\u6e05\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3001\u9838\u90e8\u900f\u4eae\u5e2f\u6e2c\u5b9a\uff09\u3068\u6bd4\u3079\u3066\u691c\u51fa\u7387\u304c\u9ad8\u304f\u3001\u507d\u967d\u6027\u7387\u304c\u4f4e\u3044\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%90%84%E6%89%8B%E6%B3%95%E3%81%AE%E7%89%B9%E5%BE%B4\"><\/span><strong>\u5404\u624b\u6cd5\u306e\u7279\u5fb4<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>WGS\uff1a\u5168\u80ce\u5150\u30b2\u30ce\u30e0\u3092\u5927\u898f\u6a21\u4e26\u5217\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u306b\u3088\u308a\u89e3\u6790\u3002\u5931\u6557\u7387\u304c\u4f4e\u304f\u3001\u8a3a\u65ad\u7bc4\u56f2\u304c\u5e83\u3044\u304c\u3001\u30b3\u30b9\u30c8\u304c\u9ad8\u3044\u3002<\/li>\n\n\n\n<li>SNP\u6cd5\uff1a\u7279\u5b9a\u306e\u591a\u578b\u90e8\u4f4d\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u3001\u30a2\u30ec\u30eb\u983b\u5ea6\u306e\u4e0d\u5747\u8861\u304b\u3089<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3092\u63a8\u5b9a\u3059\u308b\u3002<\/li>\n\n\n\n<li><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u6cd5\uff1acfDNA\u3092\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u30d7\u30ed\u30fc\u30d6\u306b\u30cf\u30a4\u30d6\u30ea\u30c0\u30a4\u30ba\u3055\u305b\u3001\u7279\u5b9a\u306e\u67d3\u8272\u4f53\u9818\u57df\u3092\u691c\u51fa\u3059\u308b\u3002<\/li>\n\n\n\n<li>RCA\u6cd5\uff1aPCR\u3084NGS\u3092\u7528\u3044\u305a\u306b\u9175\u7d20\u7684\u306b\u6a19\u7684\u914d\u5217\u3092\u5897\u5e45\u3059\u308b\u3002\u7c21\u4fbf\u304b\u3064\u30b3\u30b9\u30c8\u52b9\u7387\u306b\u512a\u308c\u308b\u304c\u3001\u691c\u51fa\u7bc4\u56f2\u306f\u9650\u5b9a\u7684\u3067\u3042\u308b\u3002<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_%E7%9B%AE%E7%9A%84\"><\/span><strong>2. \u76ee\u7684<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u672c\u30ec\u30d3\u30e5\u30fc\u306e\u76ee\u7684\u306f\u3001cfDNA\u3092\u7528\u3044\u305f\u5404\u7a2eNIPT\u624b\u6cd5\u306b\u304a\u3051\u308bT21\u3001T18\u3001T13\u306e\u691c\u51fa\u7cbe\u5ea6\u3001\u6709\u52b9\u6027\u3001\u4e88\u6e2c\u6027\u80fd\u3092\u3001\u6a19\u6e96\u7684\u306a\u8a3a\u65ad\u6cd5\uff08\u80ce\u5150\u6838\u578b\u5206\u6790\u3001\u81e8\u5e8a\u8ffd\u8de1\u306a\u3069\uff09\u3092\u57fa\u6e96\u3068\u3057\u3066\u6bd4\u8f03\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_%E6%96%B9%E6%B3%95%E8%AB%96\"><\/span><strong>3. \u65b9\u6cd5\u8ad6<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%83%87%E3%83%BC%E3%82%BF%E3%82%BD%E3%83%BC%E3%82%B9%E3%81%A8%E6%A4%9C%E7%B4%A2%E6%88%A6%E7%95%A5\"><\/span><strong>\u30c7\u30fc\u30bf\u30bd\u30fc\u30b9\u3068\u691c\u7d22\u6226\u7565<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>PubMed\u3001Embase\u3001Web of Science\u3001Scopus\u3001ClinicalTrials.gov\u3001Cochrane Library\u306e6\u3064\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u3001\u8a00\u8a9e\u30fb\u51fa\u7248\u5f62\u614b\u306e\u5236\u9650\u306a\u304f\u7cfb\u7d71\u7684\u306b\u691c\u7d22\u3002\u30ad\u30fc\u30ef\u30fc\u30c9\u306b\u306f\u4e3b\u8981\u306a\u5546\u7528NIPT\u88fd\u54c1\uff08\u4f8b\uff1a&#8221;NIFTY&#8221;, &#8220;Verifi&#8221;, &#8220;Harmony&#8221;\uff09\u3092\u542b\u3081\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%81%B8%E5%AE%9A%E5%9F%BA%E6%BA%96\"><\/span><strong>\u9078\u5b9a\u57fa\u6e96<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u542b\u3081\u305f\u7814\u7a76\uff1aTP\u3001FP\u3001FN\u3001TN\u306e\u30c7\u30fc\u30bf\u304c\u62bd\u51fa\u53ef\u80fd\u3067\u3042\u308a\u30011\u3064\u306eNIPT\u624b\u6cd5\u306b\u7279\u5316\u3057\u305f\u30d2\u30c8\u3092\u5bfe\u8c61\u3068\u3059\u308b\u7814\u7a76\u3002<\/li>\n\n\n\n<li>\u9664\u5916\u3057\u305f\u7814\u7a76\uff1a\u75c7\u4f8b\u5831\u544a\u3001\u30ec\u30d3\u30e5\u30fc\u3001\u8907\u6570\u624b\u6cd5\u3092\u4f75\u7528\u3057\u500b\u5225\u30c7\u30fc\u30bf\u304c\u5f97\u3089\u308c\u306a\u3044\u7814\u7a76\u3001\u975e\u30d2\u30c8\u307e\u305f\u306fin vitro\u7814\u7a76\u3002<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%83%87%E3%83%BC%E3%82%BF%E6%8A%BD%E5%87%BA%E9%A0%85%E7%9B%AE\"><\/span><strong>\u30c7\u30fc\u30bf\u62bd\u51fa\u9805\u76ee<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff08\u30b3\u30db\u30fc\u30c8\u3001\u75c7\u4f8b\u5bfe\u7167\u306a\u3069\uff09<\/li>\n\n\n\n<li>NIPT\u624b\u6cd5\u304a\u3088\u3073\u5546\u6a19\u540d<\/li>\n\n\n\n<li>\u691c\u67fb\u6642\u306e\u598a\u5a20\u9031\u6570<\/li>\n\n\n\n<li>\u5bfe\u8c61\u598a\u5a66\u306e\u30ea\u30b9\u30af\u5206\u985e\uff08\u9ad8\u30ea\u30b9\u30af vs \u975e\u9078\u629e\uff09<\/li>\n\n\n\n<li>\u8a3a\u65ad\u78ba\u8a8d\u6cd5\uff08\u7f8a\u6c34\u7a7f\u523a\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chorionic-villus-test\/\">\u7d68\u6bdb\u691c\u67fb<\/a>\u306a\u3069\uff09<\/li>\n\n\n\n<li>TP\u3001FP\u3001FN\u3001TN\u306e\u751f\u30c7\u30fc\u30bf<\/li>\n\n\n\n<li>\u5404\u8a3a\u65ad\u6307\u6a19\u306e\u8a08\u7b97\u5f0f\uff1a\n<ul class=\"wp-block-list\">\n<li>\u611f\u5ea6\uff1dTP \/ (TP + FN)<\/li>\n\n\n\n<li>\u7279\u7570\u5ea6\uff1dTN \/ (TN + FP)<\/li>\n\n\n\n<li>PPV\uff1dTP \/ (TP + FP)<\/li>\n\n\n\n<li>NPV\uff1dTN \/ (TN + FN)<br><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%B5%B1%E8%A8%88%E5%87%A6%E7%90%86\"><\/span><strong>\u7d71\u8a08\u51e6\u7406<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u5404\u7814\u7a76\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u306b\u57fa\u3065\u304f\u52a0\u91cd\u5e73\u5747\u3092\u7528\u3044\u3066\u6307\u6a19\u3092\u7d71\u5408\u3002\u30e1\u30bf\u5206\u6790\u624b\u6cd5\u306f\u4f7f\u7528\u3055\u308c\u305f\u304c\u3001\u7570\u8cea\u6027\u304a\u3088\u3073\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u30b5\u30a4\u30ba\u306e\u5236\u9650\u306b\u3088\u308a\u3001\u88fd\u54c1\u9593\u306e\u7d71\u8a08\u7684\u306a\u76f4\u63a5\u6bd4\u8f03\uff08\u4f8b\uff1ap\u5024\u306e\u7b97\u51fa\uff09\u306f\u884c\u308f\u308c\u3066\u3044\u306a\u3044\u3002<\/p>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4_%E7%B5%90%E6%9E%9C\"><\/span><strong>4. \u7d50\u679c<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"41_%E5%AF%BE%E8%B1%A1%E7%A0%94%E7%A9%B6%E3%81%AE%E6%A6%82%E8%A6%81\"><\/span><strong>4.1. \u5bfe\u8c61\u7814\u7a76\u306e\u6982\u8981<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u691c\u7d22\u3055\u308c\u305f538\u4ef6\u306e\u6587\u732e\u306e\u3046\u3061\u300120\u4ef6\u306e\u8ad6\u6587\uff0821\u4ef6\u306e\u72ec\u7acb\u3057\u305f\u7814\u7a76\uff09\u304c\u542b\u307e\u308c\u305f\u3002\u5206\u6790\u5bfe\u8c61\u306f\u4ee5\u4e0b\u306e\u901a\u308a\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>WGS\u30d9\u30fc\u30b9\uff1a10\u4ef6<\/li>\n\n\n\n<li>SNP\u30d9\u30fc\u30b9\uff1a2\u4ef6<\/li>\n\n\n\n<li><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u30d9\u30fc\u30b9\uff1a4\u4ef6<\/li>\n\n\n\n<li>RCA\u30d9\u30fc\u30b9\uff1a5\u4ef6<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p>\u5168\u4f53\u306792,164\u4ef6\u306e\u598a\u5a20\u4f8b\u304c\u542b\u307e\u308c\u3001T21\u306e\u78ba\u5b9a\u75c7\u4f8b\u306f1245\u4ef6\u3067\u3042\u3063\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"42_%E6%9F%93%E8%89%B2%E4%BD%93%E7%95%B0%E5%B8%B8%E5%88%A5%E3%81%8A%E3%82%88%E3%81%B3%E6%89%8B%E6%B3%95%E5%88%A5%E3%81%AE%E8%A8%BA%E6%96%AD%E7%B2%BE%E5%BA%A6\"><\/span><strong>4.2. \u67d3\u8272\u4f53\u7570\u5e38\u5225\u304a\u3088\u3073\u624b\u6cd5\u5225\u306e\u8a3a\u65ad\u7cbe\u5ea6<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%83%88%E3%83%AA%E3%82%BD%E3%83%9F%E3%83%BC21%EF%BC%88%E3%83%80%E3%82%A6%E3%83%B3%E7%97%87%EF%BC%89\"><\/span><strong>\u30c8\u30ea\u30bd\u30df\u30fc21\uff08\u30c0\u30a6\u30f3\u75c7\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u611f\u5ea6\uff1a\u3059\u3079\u3066\u306e\u624b\u6cd5\u306797%\u4ee5\u4e0a\u3002WGS\u3001SNP\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u306f100%\u306b\u9054\u3059\u308b\u4f8b\u304c\u591a\u3044\u3002<\/li>\n\n\n\n<li>\u7279\u7570\u5ea6\uff1a\u3059\u3079\u3066\u306e\u624b\u6cd5\u306799%\u4ee5\u4e0a\u3002<\/li>\n\n\n\n<li>PPV\uff1aSNP\uff0892.97%\uff09\u3068RCA\uff0875.98%\uff09\u306f\u3001WGS\u304a\u3088\u3073<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u306b\u6bd4\u3079\u3066\u4f4e\u3044\u3002<\/li>\n\n\n\n<li>NPV\uff1a\u3059\u3079\u3066\u306e\u624b\u6cd5\u306799%\u4ee5\u4e0a\u3002<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%83%88%E3%83%AA%E3%82%BD%E3%83%9F%E3%83%BC18\"><\/span><strong>\u30c8\u30ea\u30bd\u30df\u30fc18<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u611f\u5ea6\uff1aWGS\u304a\u3088\u3073SNP\u306f\u307b\u307c100%\u3002<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u306f\u5e73\u574777%\u3068\u4f4e\u3081\u3002<\/li>\n\n\n\n<li>\u7279\u7570\u5ea6\uff1a\u5168\u624b\u6cd5\u306799%\u4ee5\u4e0a\u3002<\/li>\n\n\n\n<li>PPV\uff1aRCA\u304a\u3088\u3073\u4e00\u90e8WGS\u3067\u306f\u4f4e\u4e0b\uff0860\uff5e84%\uff09\u3002<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u3067\u306f\u9ad8\u6c34\u6e96\u3092\u7dad\u6301\u3002<\/li>\n\n\n\n<li>NPV\uff1a\u3059\u3079\u3066\u306e\u624b\u6cd5\u306799%\u4ee5\u4e0a\u3002<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%83%88%E3%83%AA%E3%82%BD%E3%83%9F%E3%83%BC13\"><\/span><strong>\u30c8\u30ea\u30bd\u30df\u30fc13<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u611f\u5ea6\uff1a\u307b\u307c\u3059\u3079\u3066100%\u3067\u3042\u3063\u305f\u304c\u3001RCA\u306e1\u7814\u7a76\u3067\u306f62.5%\u3068\u4f4e\u4e0b\u3002<\/li>\n\n\n\n<li>\u7279\u7570\u5ea6\uff1a\u3059\u3079\u306699%\u4ee5\u4e0a\u3002<\/li>\n\n\n\n<li>PPV\uff1a\u6982\u306d\u9ad8\u5024\uff0898%\u4ee5\u4e0a\uff09\u3060\u304c\u3001WGS\u306e1\u7814\u7a76\u3067\u306f83.3%\u3002<\/li>\n\n\n\n<li>NPV\uff1a\u3059\u3079\u3066\u306e\u624b\u6cd5\u306799%\u4ee5\u4e0a\u3002<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"5_%E8%80%83%E5%AF%9F\"><\/span><strong>5. \u8003\u5bdf<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"51_%E8%A7%A3%E9%87%88\"><\/span><strong>5.1. \u89e3\u91c8<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u3059\u3079\u3066\u306eNIPT\u624b\u6cd5\u306b\u304a\u3044\u3066\u3001\u611f\u5ea6\u30fb\u7279\u7570\u5ea6\u30fbNPV\u306f\u4e00\u8cab\u3057\u3066\u9ad8\u3044\u3002<\/li>\n\n\n\n<li>PPV\u306fRCA\u304a\u3088\u3073SNP\u3067\u5909\u52d5\u304c\u5927\u304d\u304f\u3001\u6bcd\u96c6\u56e3\u306e\u30ea\u30b9\u30af\u3084\u80ce\u76e4<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u306a\u3069\u306e\u751f\u7269\u5b66\u7684\u5909\u52d5\u304c\u5f71\u97ff\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u306fT18\u306b\u5bfe\u3057\u3066\u611f\u5ea6\u304c\u3084\u3084\u52a3\u308b\u3002<\/li>\n\n\n\n<li>RCA\u306fT21\u304a\u3088\u3073T18\u306ePPV\u304c\u4f4e\u304f\u3001\u967d\u6027\u7d50\u679c\u306b\u5bfe\u3057\u3066\u4fb5\u8972\u7684\u691c\u67fb\u306e\u4f75\u7528\u304c\u5fc5\u8981\u3002<br><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"52_%E7%B5%8C%E6%B8%88%E7%9A%84%E3%83%BB%E8%87%A8%E5%BA%8A%E7%9A%84%E8%A6%B3%E7%82%B9\"><\/span><strong>5.2. \u7d4c\u6e08\u7684\u30fb\u81e8\u5e8a\u7684\u89b3\u70b9<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>NIPT\u306f\u5f93\u6765\u6cd5\uff08T21\u306b\u5bfe\u3059\u308b\u691c\u51fa\u738782\u301c87%\uff09\u306b\u6bd4\u3079\u3066\u7cbe\u5ea6\u304c\u9ad8\u3044\u3002<\/li>\n\n\n\n<li>\u304b\u3064\u3066\u306fNIPT\u3092\u4e00\u6b21\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3068\u3059\u308b\u3053\u3068\u306f\u8cbb\u7528\u52b9\u679c\u304c\u4f4e\u3044\u3068\u3055\u308c\u3066\u3044\u305f\u304c\u3001\u4fa1\u683c\u4f4e\u4e0b\u3068\u7cbe\u5ea6\u5411\u4e0a\u306b\u3088\u308a\u8a55\u4fa1\u304c\u5909\u5316\u3002<\/li>\n\n\n\n<li>2023\u5e74\u306e\u7d4c\u6e08\u5206\u6790\u3067\u306f\u3001NIPT\u3092\u521d\u56de\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3068\u3059\u308b\u6226\u7565\u304c\u3001\u751f\u6daf\u533b\u7642\u8cbb\u306e\u524a\u6e1b\u3068T21\u306e\u898b\u9003\u3057\u9632\u6b62\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<br><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"53_%E6%96%B9%E6%B3%95%E8%AB%96%E4%B8%8A%E3%81%AE%E7%95%99%E6%84%8F%E7%82%B9\"><\/span><strong>5.3. \u65b9\u6cd5\u8ad6\u4e0a\u306e\u7559\u610f\u70b9<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5927\u534a\u306e\u7814\u7a76\u306f\u30b3\u30db\u30fc\u30c8\u578b\u3067\u3042\u308a\u3001\u4e00\u90e8\u306f\u5f8c\u308d\u5411\u304d\u7814\u7a76\u3002<\/li>\n\n\n\n<li>\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u306f600\u672a\u6e80\u304b\u308944,000\u8d85\u307e\u3067\u5927\u304d\u304f\u7570\u306a\u308b\u3002<\/li>\n\n\n\n<li>\u7121\u4f5c\u70ba\u5316\u3055\u308c\u3066\u3044\u306a\u3044\u8a2d\u8a08\u3001\u598a\u5a20\u9031\u6570\u306e\u4e0d\u5747\u4e00\u6027\u3001\u81ea\u7136<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u3084\u8ffd\u8de1\u4e0d\u80fd\u4f8b\u306e\u5831\u544a\u6b20\u5982\u306a\u3069\u304c\u30d0\u30a4\u30a2\u30b9\u8981\u56e0\u3068\u306a\u308b\u3002<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"6_%E9%99%90%E7%95%8C\"><\/span><strong>6. \u9650\u754c<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>SNP\u304a\u3088\u3073RCA\u624b\u6cd5\u306e\u7814\u7a76\u6570\u304c\u5c11\u306a\u304f\u3001\u624b\u6cd5\u9593\u306e\u76f4\u63a5\u6bd4\u8f03\u304c\u5236\u9650\u3055\u308c\u305f\u3002<\/li>\n\n\n\n<li>\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u3001\u5bfe\u8c61\u96c6\u56e3\u306e\u30ea\u30b9\u30af\u3001\u8a3a\u65ad\u78ba\u8a8d\u6cd5\u306e\u9055\u3044\u306b\u3088\u308b\u7570\u8cea\u6027\u304c\u5b58\u5728\u3059\u308b\u3002<\/li>\n\n\n\n<li>\u7d71\u8a08\u7684\u6bd4\u8f03\uff08p\u5024\u306a\u3069\uff09\u306f\u5b9f\u65bd\u3055\u308c\u3066\u3044\u306a\u3044\u3002<\/li>\n\n\n\n<li>\u591a\u304f\u306e\u7814\u7a76\u304c\u9ad8\u30ea\u30b9\u30af\u598a\u5a20\u3092\u5bfe\u8c61\u3068\u3057\u3066\u304a\u308a\u3001\u4e00\u822c\u96c6\u56e3\u3078\u306e\u9069\u7528\u53ef\u80fd\u6027\u306b\u306f\u614e\u91cd\u306a\u691c\u8a0e\u304c\u5fc5\u8981\u3002<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"7_%E7%B5%90%E8%AB%96\"><\/span><strong>7. \u7d50\u8ad6<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E4%B8%BB%E3%81%AA%E6%89%80%E8%A6%8B\"><\/span><strong>\u4e3b\u306a\u6240\u898b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8a55\u4fa1\u5bfe\u8c61\u306e\u3059\u3079\u3066\u306eNIPT\u624b\u6cd5\uff08WGS\u3001SNP\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u3001RCA\uff09\u306f\u3001T21\u3001T18\u3001T13\u306e\u691c\u51fa\u306b\u304a\u3044\u3066\u81e8\u5e8a\u7684\u306b\u6709\u52b9\u3002<\/li>\n\n\n\n<li>WGS\u30d9\u30fc\u30b9\u306e\u691c\u67fb\u306f\u6700\u3082\u6c4e\u7528\u6027\u304c\u9ad8\u304f\u3001\u5e83\u7bc4\u306a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u691c\u51fa\u304c\u53ef\u80fd\u3002<\/li>\n\n\n\n<li>SNP\u304a\u3088\u3073RCA\u30d9\u30fc\u30b9\u306e\u691c\u67fb\u306f\u3001PPV\u304c\u4e00\u8cab\u3057\u3066\u4f4e\u304f\u3001\u967d\u6027\u4f8b\u306b\u306f\u78ba\u5b9a\u8a3a\u65ad\u304c\u5fc5\u8981\u3002<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%87%A8%E5%BA%8A%E7%9A%84%E6%8E%A8%E5%A5%A8\"><\/span><strong>\u81e8\u5e8a\u7684\u63a8\u5968<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>NIPT\u3068\u8d85\u97f3\u6ce2\u691c\u67fb\u306e\u4f75\u7528\u304c\u3001\u611f\u5ea6\u30fb\u8cbb\u7528\u5bfe\u52b9\u679c\u30fb\u81e8\u5e8a\u7684\u4fe1\u983c\u6027\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u6700\u3082\u826f\u304f\u3059\u308b\u8a3a\u65ad\u6226\u7565\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"8_%E4%BB%8A%E5%BE%8C%E3%81%AE%E7%A0%94%E7%A9%B6%E3%81%B8%E3%81%AE%E7%A4%BA%E5%94%86\"><\/span><strong>8. \u4eca\u5f8c\u306e\u7814\u7a76\u3078\u306e\u793a\u5506<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5404NIPT\u624b\u6cd5\u3092\u76f4\u63a5\u6bd4\u8f03\u3059\u308b\u5927\u898f\u6a21\u306a\u7121\u4f5c\u70ba\u5316\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002<\/li>\n\n\n\n<li>\u691c\u67fb\u5931\u6557\u7387\u3001\u7a00\u306a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u691c\u51fa\u6027\u80fd\u3001\u7570\u306a\u308b\u6bcd\u96c6\u56e3\u306b\u304a\u3051\u308b\u8cbb\u7528\u5bfe\u52b9\u679c\u306e\u8a55\u4fa1\u304c\u6c42\u3081\u3089\u308c\u308b\u3002<\/li>\n\n\n\n<li>\u598a\u5a66\u306e\u30ea\u30b9\u30af\u72b6\u6cc1\u3001\u598a\u5a20\u9031\u6570\u3001\u8ffd\u8de1\u7d50\u679c\u306b\u95a2\u3059\u308b\u5831\u544a\u306e\u6a19\u6e96\u5316\u304c\u4eca\u5f8c\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u91cd\u8981\u3067\u3042\u308b\u3002<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%94%A8%E8%AA%9E%E9%9B%86\"><\/span><strong>\u7528\u8a9e\u96c6<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>cfDNA\uff1a\u30bb\u30eb\u30d5\u30ea\u30fcDNA\uff08\u80ce\u5150\u7531\u6765\uff09<\/li>\n\n\n\n<li>PPV\/NPV\uff1a\u967d\u6027\/\u9670\u6027\u7684\u4e2d\u7387<\/li>\n\n\n\n<li>TP\/FP\/FN\/TN\uff1a\u771f\u967d\u6027\/\u507d\u967d\u6027\/\u507d\u9670\u6027\/\u771f\u9670\u6027<\/li>\n\n\n\n<li>WGS\uff1a\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0<\/li>\n\n\n\n<li>SNP\uff1a\u4e00\u5869\u57fa\u591a\u578b<\/li>\n\n\n\n<li>RCA\uff1a\u30ed\u30fc\u30ea\u30f3\u30b0\u30b5\u30fc\u30af\u30eb\u5897\u5e45\u6cd5<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n","protected":false},"excerpt":{"rendered":"\u3053\u306e\u8a18\u4e8b\u306e\u307e\u3068\u3081\u3053\u306e\u30da\u30fc\u30b8\u306f\u3001NIPT\uff08&#8230;\n <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-types-comparison-guide\/\">\u7d9a\u304d\u3092\u8aad\u3080<\/a>","protected":false},"author":79,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[394],"tags":[],"class_list":["post-100565","post","type-post","status-publish","format-standard","hentry","category-uncategorized-2"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/100565","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/users\/79"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/comments?post=100565"}],"version-history":[{"count":41,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/100565\/revisions"}],"predecessor-version":[{"id":125358,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/100565\/revisions\/125358"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=100565"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/categories?post=100565"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/tags?post=100565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}