{"id":106165,"date":"2025-07-28T14:26:48","date_gmt":"2025-07-28T05:26:48","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/?p=106165"},"modified":"2025-07-28T15:01:52","modified_gmt":"2025-07-28T06:01:52","slug":"asd-wnt-canonical-pathway-overview","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\/","title":{"rendered":"\u81ea\u9589\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u75c7\u306e\u79d1\u5b66\uff1aWnt\/\u03b2-catenin signaling\u3068\u767a\u9054\u969c\u5bb3\u306e\u3064\u306a\u304c\u308a"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<div style=\"border: 4px solid #80c1ea; background-color: #f8fcff; border-radius: 12px; padding: 1.5rem; margin: 1.5rem 0 2.5rem; font-family: 'Helvetica Neue', sans-serif; line-height: 1.6; box-shadow: 0 2px 8px rgba(0, 0, 0, 0.04);\">\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 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class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\/#Wnt%CE%B2-%E3%82%AB%E3%83%86%E3%83%8B%E3%83%B3%E7%B5%8C%E8%B7%AF%E3%81%AE%E5%88%86%E5%AD%90%E6%A9%9F%E6%A7%8B%EF%BD%9CWnt%CE%B2-Catenin_Signaling_Mechanism\" >Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306e\u5206\u5b50\u6a5f\u69cb\uff5cWnt\/\u03b2-Catenin Signaling Mechanism<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\/#%E7%96%BE%E6%82%A3%E5%90%8D%EF%BD%9CDisorder\" >\u75be\u60a3\u540d\uff5cDisorder<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\/#%E7%97%87%E7%8A%B6%EF%BD%9CSymptoms\" >\u75c7\u72b6\uff5cSymptoms<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\/#%E7%96%AB%E5%AD%A6%EF%BD%9CEpidemiology\" >\u75ab\u5b66\uff5cEpidemiology<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\/#ASD%E3%81%AB%E9%96%A2%E4%B8%8E%E3%81%99%E3%82%8B%E4%B8%BB%E8%A6%81%E9%81%BA%E4%BC%9D%E5%AD%90%EF%BD%9CKey_Genes_Implicated_in_ASD_via_Wnt%CE%B2-Catenin_Pathway\" >ASD\u306b\u95a2\u4e0e\u3059\u308b\u4e3b\u8981\u907a\u4f1d\u5b50\uff5cKey Genes Implicated in ASD via Wnt\/\u03b2-Catenin Pathway<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\/#ASD%E3%81%AE%E7%97%85%E5%9B%A0%EF%BC%9A%E9%81%BA%E4%BC%9D%E7%9A%84%E3%81%8A%E3%82%88%E3%81%B3%E7%92%B0%E5%A2%83%E7%9A%84%E8%A6%81%E5%9B%A0%E3%81%AE%E7%B5%B1%E5%90%88%EF%BD%9CEtiology_of_ASD_Genetic_and_Environmental_Integration\" >ASD\u306e\u75c5\u56e0\uff1a\u907a\u4f1d\u7684\u304a\u3088\u3073\u74b0\u5883\u7684\u8981\u56e0\u306e\u7d71\u5408\uff5cEtiology of ASD: Genetic and Environmental Integration<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\/#%E9%81%BA%E4%BC%9D%E7%9A%84%E3%83%A1%E3%82%AB%E3%83%8B%E3%82%BA%E3%83%A0\" >\u907a\u4f1d\u7684\u30e1\u30ab\u30cb\u30ba\u30e0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\/#%E7%92%B0%E5%A2%83%E8%A6%81%E5%9B%A0%E3%81%A8Wnt%E7%B5%8C%E8%B7%AF%E3%81%AE%E6%92%B9%E4%B9%B1\" >\u74b0\u5883\u8981\u56e0\u3068Wnt\u7d4c\u8def\u306e\u64b9\u4e71<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\/#%E7%B7%8F%E6%8B%AC\" >\u7dcf\u62ec<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\/#%E6%A4%9C%E6%9F%BB%E3%83%BB%E8%A8%BA%E6%96%AD%EF%BD%9CTesting_Diagnosis\" >\u691c\u67fb\u30fb\u8a3a\u65ad\uff5cTesting &amp; Diagnosis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\/#%E6%B2%BB%E7%99%82%E6%B3%95%E3%81%A8%E7%AE%A1%E7%90%86%EF%BD%9CTreatment_Management\" >\u6cbb\u7642\u6cd5\u3068\u7ba1\u7406\uff5cTreatment &amp; Management<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\/#%E7%B5%8C%E8%B7%AF%E6%8A%91%E5%88%B6%E8%96%AC%EF%BC%88Pathway_Inhibitors%EF%BC%89\" >\u7d4c\u8def\u6291\u5236\u85ac\uff08Pathway Inhibitors\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\/#%E7%B5%8C%E8%B7%AF%E6%B4%BB%E6%80%A7%E5%8C%96%E8%96%AC%EF%BC%88Pathway_Activators%EF%BC%89\" >\u7d4c\u8def\u6d3b\u6027\u5316\u85ac\uff08Pathway Activators\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\/#%E3%81%9D%E3%81%AE%E4%BB%96%E3%81%AE%E8%AA%BF%E7%AF%80%E5%9B%A0%E5%AD%90\" >\u305d\u306e\u4ed6\u306e\u8abf\u7bc0\u56e0\u5b50<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\/#%E8%87%A8%E5%BA%8A%E3%81%AB%E3%81%8A%E3%81%91%E3%82%8B%E7%95%99%E6%84%8F%E7%82%B9\" >\u81e8\u5e8a\u306b\u304a\u3051\u308b\u7559\u610f\u70b9<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\/#%E4%BA%88%E5%BE%8C%EF%BD%9CPrognosis\" >\u4e88\u5f8c\uff5cPrognosis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\/#%E5%BC%95%E7%94%A8%E6%96%87%E7%8C%AE%EF%BD%9CReferences\" >\u5f15\u7528\u6587\u732e\uff5cReferences<\/a><\/li><\/ul><\/nav><\/div>\n<h2 style=\"margin-top: 0; margin-bottom: 0.75rem; font-size: 1.25rem; color: #2a79b8; text-align: left; border-bottom: 2px solid #a6cbdc; padding-bottom: 0.25rem;\"><span class=\"ez-toc-section\" id=\"%E3%82%84%E3%81%95%E3%81%97%E3%81%84%E3%81%BE%E3%81%A8%E3%82%81\"><\/span>\n  \u3084\u3055\u3057\u3044\u307e\u3068\u3081\n<span class=\"ez-toc-section-end\"><\/span><\/h2>\n  <p style=\"margin: 0; font-size: 1rem; color: #333;\">\n<div>\n  <p>\n    <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-spectrum-disorder-genetics\/\">\u81ea\u9589\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u75c7<\/a>\uff08Autism Spectrum Disorder\uff1aASD\uff09\u306f\u3001\u3053\u3068\u3070\u306e\u767a\u9054\u306e\u9045\u308c\u3084\u793e\u4f1a\u7684\u306a\u3084\u308a\u3068\u308a\u306e\u3080\u305a\u304b\u3057\u3055\u3001\u304f\u308a\u8fd4\u3057\u306e\u884c\u52d5\u306a\u3069\u304c\u7279\u5fb4\u306e\u795e\u7d4c\u767a\u9054\u75c7\u3067\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u3053\u3046\u3057\u305f\u767a\u9054\u306e\u7279\u6027\u306b\u3001\u8133\u5185\u306e\u60c5\u5831\u4f1d\u9054\u3092\u62c5\u3046\u300cWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\uff08\u30ab\u30ce\u30cb\u30ab\u30ebWnt\u30b7\u30b0\u30ca\u30eb\uff09\u300d\u306e\u7570\u5e38\u304c\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\n  <\/p>\n  <p>\n    \u3053\u306e\u7d4c\u8def\u306f\u3001\u80ce\u5150\u671f\u306e\u8133\u306e\u767a\u9054\u306b\u6df1\u304f\u95a2\u308f\u3063\u3066\u304a\u308a\u3001\u795e\u7d4c\u7d30\u80de\u306e\u6210\u9577\u3084\u3064\u306a\u304c\u308a\u3092\u8abf\u6574\u3057\u3066\u3044\u307e\u3059\u3002Wnt\u30b7\u30b0\u30ca\u30eb\u306e\u50cd\u304d\u304c\u904e\u5270\u307e\u305f\u306f\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u8133\u306e\u69cb\u9020\u3084\u795e\u7d4c\u56de\u8def\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u3001ASD\u306e\u3055\u307e\u3056\u307e\u306a\u75c7\u72b6\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u7279\u306b\u3001CHD8\u3001CTNNB1\u3001WNT2\u3001TCF7L2\u306a\u3069\u306e\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306e\u5897\u6b96\u3084\u30b7\u30ca\u30d7\u30b9\u306e\u5f62\u6210\u7570\u5e38\u3068\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\n  <\/p>\n  <p>\n    \u672c\u8a18\u4e8b\u3067\u306f\u3001Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u304c\u3069\u306e\u3088\u3046\u306bASD\u3068\u95a2\u4fc2\u3057\u3066\u3044\u308b\u306e\u304b\u3001\u75c7\u72b6\u3001\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u3001\u691c\u67fb\u3001\u305d\u3057\u3066\u5c06\u6765\u306e\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u3001\u5c02\u9580\u7684\u306a\u5185\u5bb9\u3092\u3084\u3055\u3057\u304f\u89e3\u8aac\u3057\u3066\u3044\u307e\u3059\u3002\u304a\u5b50\u3055\u307e\u306e\u767a\u9054\u306b\u3054\u4e0d\u5b89\u3092\u304a\u6301\u3061\u306e\u65b9\u3084\u3001ASD\u306b\u3064\u3044\u3066\u3088\u308a\u6df1\u304f\u77e5\u308a\u305f\u3044\u65b9\u306b\u5411\u3051\u3066\u3001\u6700\u65b0\u306e\u7814\u7a76\u306b\u57fa\u3065\u3044\u305f\u5b89\u5fc3\u3067\u304d\u308b\u60c5\u5831\u3092\u304a\u5c4a\u3051\u3057\u307e\u3059\u3002\n  <\/p>\n<\/div>\n\n<\/p>\n  <\/p>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%A6%82%E8%A6%81%E3%81%A8%E8%83%8C%E6%99%AF%EF%BD%9COverview_Background\"><\/span>\u6982\u8981\u3068\u80cc\u666f\uff5cOverview &amp; Background<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-spectrum-disorder-genetics\/\">\u81ea\u9589\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u75c7<\/a>\uff08Autism Spectrum Disorder\uff1aASD\uff09\u306f\u3001\u793e\u4f1a\u7684\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u306e\u56f0\u96e3\u3055\u3084\u53cd\u5fa9\u7684\u306a\u884c\u52d5\u3001\u8208\u5473\u306e\u304b\u305f\u3088\u308a\u3092\u7279\u5fb4\u3068\u3059\u308b\u795e\u7d4c\u767a\u9054\u75c7\u3067\u3042\u308a\u3001\u907a\u4f1d\u7684\u80cc\u666f\u3084\u767a\u9054\u4e2d\u306e\u795e\u7d4c\u56de\u8def\u5f62\u6210\u306e\u7570\u5e38\u304c\u8907\u96d1\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002ASD\u306f\u591a\u56e0\u5b50\u6027\u304b\u3064\u591a\u907a\u4f1d\u5b50\u6027\uff08polygenic\uff09\u306a\u75be\u60a3\u3067\u3042\u308a\u3001\u305d\u306e\u8868\u73fe\u578b\u306e\u591a\u69d8\u6027\u304b\u3089\u3001\u5f93\u6765\u306f\u300c\u7570\u8cea\u6027\u306e\u9ad8\u3044\u75c7\u5019\u7fa4\u300d\u3068\u3057\u3066\u6349\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u8fd1\u5e74\u3001ASD\u306b\u95a2\u9023\u3059\u308b\u8907\u6570\u306e\u907a\u4f1d\u7684\u8981\u56e0\u304c\u3001\u5171\u901a\u3057\u3066\u30ab\u30ce\u30cb\u30ab\u30ebWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\uff08canonical Wnt\/\u03b2-catenin signaling pathway\uff09\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u7d4c\u8def\u306f\u4e2d\u67a2\u795e\u7d4c\u7cfb\uff08CNS\uff09\u306e\u767a\u9054\u306b\u304a\u3044\u3066\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u30d7\u30ed\u30bb\u30b9\u3092\u8abf\u7bc0\u3057\u3066\u3044\u307e\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u795e\u7d4c\u524d\u99c6\u7d30\u80de\uff08neural progenitor cells\uff09\u306e\u5897\u6b96\u3068\u5206\u5316<br><\/li>\n\n\n\n<li>\u795e\u7d4c\u7d30\u80de\u306e\u79fb\u52d5\u3001\u304a\u3088\u3073\u5927\u8133\u76ae\u8cea\u306e\u5c64\u69cb\u9020\u5f62\u6210\uff08\u76ae\u8cea\u30e9\u30df\u30cd\u30fc\u30b7\u30e7\u30f3\uff09<br><\/li>\n\n\n\n<li>\u30b7\u30ca\u30d7\u30b9\u306e\u5f62\u6210\u3068\u6a39\u72b6\u7a81\u8d77\u30b9\u30d1\u30a4\u30f3\u306e\u6210\u9577<br><\/li>\n\n\n\n<li>\u795e\u7d4c\u56de\u8def\u306e\u53ef\u5851\u6027\uff08\u67d4\u8edf\u306a\u5909\u5316\uff09\u3068\u5b89\u5b9a\u6027\u306e\u7dad\u6301<\/li>\n<\/ul>\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>ASD\u60a3\u8005\u304a\u3088\u3073\u30e2\u30c7\u30eb\u52d5\u7269\u306b\u304a\u3044\u3066\u3001Wnt\u7d4c\u8def\u306e\u7570\u5e38\u306f\u5927\u8133\u76ae\u8cea\u306e\u904e\u5f62\u6210\uff08\u5927\u982d\u75c7\uff09\u3001\u30b7\u30ca\u30d7\u30b9\u5f62\u6210\u7570\u5e38\u3001\u795e\u7d4c\u56de\u8def\u306e\u63a5\u7d9a\u6027\u306e\u5909\u5316\u306a\u3069\u3001\u795e\u7d4c\u767a\u9054\u306e\u3055\u307e\u3056\u307e\u306a\u5074\u9762\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u591a\u304f\u306e\u7814\u7a76\u3067\u3001Wnt\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u7570\u5e38\u304cASD\u306e\u75c5\u614b\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3059\u3079\u3066\u306eASD\u306e\u65b9\u306b\u540c\u3058\u3088\u3046\u306a\u5909\u5316\u304c\u898b\u3089\u308c\u308b\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u56e0\u679c\u95a2\u4fc2\u306b\u3064\u3044\u3066\u306f\u73fe\u5728\u3082\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u308b\u6bb5\u968e\u3067\u3059\u3002ASD\u306b\u306f\u3001Wnt\u7d4c\u8def\u4ee5\u5916\u306b\u3082\u591a\u304f\u306e\u5206\u5b50\u7d4c\u8def\u304c\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u672c\u8a18\u4e8b\u3067\u306f\u3001\u305d\u3046\u3057\u305f\u8907\u96d1\u306a\u80cc\u666f\u306e\u4e2d\u304b\u3089\u3001\u672c\u8a18\u4e8b\u3067\u306f\u3001Wnt\u30b7\u30b0\u30ca\u30eb\u3068\u3044\u3046\u3072\u3068\u3064\u306e\u8996\u70b9\u304b\u3089ASD\u3092\u898b\u3064\u3081\u76f4\u3057\u3001\u7406\u89e3\u3092\u6df1\u3081\u308b\u305f\u3081\u306e\u5c0f\u3055\u306a\u624b\u304c\u304b\u308a\u3068\u306a\u308b\u3053\u3068\u3092\u9858\u3063\u3066\u3054\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wnt%CE%B2-%E3%82%AB%E3%83%86%E3%83%8B%E3%83%B3%E7%B5%8C%E8%B7%AF%E3%81%AE%E5%88%86%E5%AD%90%E6%A9%9F%E6%A7%8B%EF%BD%9CWnt%CE%B2-Catenin_Signaling_Mechanism\"><\/span>Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306e\u5206\u5b50\u6a5f\u69cb\uff5cWnt\/\u03b2-Catenin Signaling Mechanism<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u3053\u306e\u7d4c\u8def\u306f\u3001\u7d30\u80de\u5916\u30ea\u30ac\u30f3\u30c9\u3067\u3042\u308bWnt\u30bf\u30f3\u30d1\u30af\u8cea\u304cFrizzled\uff08FZD\uff09\u53d7\u5bb9\u4f53\u3068\u5171\u53d7\u5bb9\u4f53LRP5\/6\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u59cb\u307e\u308a\u307e\u3059\u3002\u3053\u306e\u30b7\u30b0\u30ca\u30eb\u306b\u3088\u3063\u3066\u3001\u901a\u5e38\u306f\u03b2-\u30ab\u30c6\u30cb\u30f3\u3092\u5206\u89e3\u3059\u308b\u8907\u5408\u4f53\uff08Axin\u3001APC\u3001GSK-3\u03b2\u3001CK1\u03b1\uff09\u304c\u4e0d\u6d3b\u6027\u5316\u3055\u308c\u3001\u03b2-\u30ab\u30c6\u30cb\u30f3\u304c\u7d30\u80de\u8cea\u5185\u306b\u5b89\u5b9a\u5316\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5b89\u5b9a\u5316\u3057\u305f\u03b2-\u30ab\u30c6\u30cb\u30f3\u306f\u7d30\u80de\u6838\u306b\u79fb\u884c\u3057\u3001LEF\/TCF\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u8ee2\u5199\u56e0\u5b50\u3068\u7d50\u5408\u3057\u3066\u3001\u795e\u7d4c\u767a\u9054\u306b\u95a2\u9023\u3059\u308b\u3055\u307e\u3056\u307e\u306a\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3057\u307e\u3059\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u8ee2\u5199\u8abf\u7bc0\u56e0\u5b50\u3082\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5171\u6d3b\u6027\u5316\u56e0\u5b50\uff1aCBP\uff08CREBBP\uff09\u3001BCL9 \u306a\u3069<br><\/li>\n\n\n\n<li>\u8ee2\u5199\u6291\u5236\u56e0\u5b50\uff1aGroucho\u3001NCoR\/SMRT\u8907\u5408\u4f53\u306a\u3069<br><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u56e0\u5b50\u306e\u591a\u304f\u306f\u3001ASD\u60a3\u8005\u3067\u6a5f\u80fd\u55aa\u5931\u578b\u5909\u7570\uff08loss-of-function\uff09\u307e\u305f\u306f\u6a5f\u80fd\u4ea2\u9032\u578b\u5909\u7570\uff08gain-of-function\uff09\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u30ec\u30d9\u30eb\u3067\u306e\u30b7\u30b0\u30ca\u30eb\u8abf\u7bc0\u7570\u5e38\u304c\u795e\u7d4c\u767a\u9054\u306b\u53ca\u307c\u3059\u5f71\u97ff\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306f\u3001Hedgehog\u3001Notch\u3001BMP\u3001\u30ec\u30c1\u30ce\u30a4\u30f3\u9178\u7d4c\u8def\u306a\u3069\u3001\u4ed6\u306e\u767a\u9054\u7d4c\u8def\u3068\u5bc6\u63a5\u306b\u9023\u643a\u3057\u3066\u304a\u308a\u3001\u795e\u7d4c\u767a\u9054\u306b\u304a\u3051\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u8907\u96d1\u306a\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u5f62\u6210\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%96%BE%E6%82%A3%E5%90%8D%EF%BD%9CDisorder\"><\/span>\u75be\u60a3\u540d\uff5cDisorder<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>ASD\u306f\u3001\u795e\u7d4c\u767a\u9054\u306b\u95a2\u308f\u308b\u72b6\u614b\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u3042\u308a\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u7279\u5fb4\u304c\u307f\u3089\u308c\u307e\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u793e\u4f1a\u7684\u306a\u76f8\u4e92\u4f5c\u7528\u3084\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u306e\u6301\u7d9a\u7684\u306a\u56f0\u96e3<\/li>\n\n\n\n<li>\u8208\u5473\u3084\u884c\u52d5\u304c\u304b\u305f\u3088\u308b\u50be\u5411\u3001\u304a\u3088\u3073\u305d\u308c\u304c\u7e70\u308a\u8fd4\u3055\u308c\u308b\u3053\u3068<\/li>\n<\/ul>\n\n\n\n<p>ASD\u306f\u3001\u305d\u306e\u73fe\u308c\u65b9\u304c\u975e\u5e38\u306b\u591a\u69d8\u3067\u3001\u300c\u30b9\u30da\u30af\u30c8\u30e9\u30e0\uff08\u9023\u7d9a\u4f53\uff09\u300d\u3068\u3044\u3046\u8a00\u8449\u304c\u4f7f\u308f\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u3001\u75c7\u72b6\u306e\u91cd\u3055\u3084\u7bc4\u56f2\u306f\u4eba\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u65e9\u3044\u6642\u671f\u304b\u3089\u306e\u5927\u982d\u75c7\uff08\u982d\u56f2\u304c\u5e73\u5747\u3088\u308a\u5927\u304d\u3044\u72b6\u614b\uff09\u3001\u8a00\u8449\u306e\u767a\u9054\u306e\u9045\u308c\u3001\u611f\u899a\u306e\u904e\u654f\u30fb\u920d\u611f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/why-premium-plan\/\">\u77e5\u7684\u969c\u304c\u3044<\/a>\u3092\u3068\u3082\u306a\u3046\u5834\u5408\u306a\u3069\u3001\u591a\u5f69\u306a\u7279\u5fb4\u304c\u7d44\u307f\u5408\u308f\u3055\u3063\u3066\u73fe\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6700\u8fd1\u306e\u5206\u5b50\u751f\u7269\u5b66\u7684\u306a\u7814\u7a76\u3067\u306f\u3001Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306e\u7570\u5e38\u304c\u3001ASD\u306e\u4e2d\u3067\u3082\u300c\u75c7\u5019\u6027ASD\uff08syndromic ASD\uff09\u300d\u3068\u300c\u7279\u5225\u306a\u75be\u60a3\u306b\u5e30\u5c5e\u3057\u306a\u3044ASD\uff08idiopathic ASD\uff09\u300d\u306e\u4e21\u65b9\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001CHD8\u3001CTNNB1\u3001TCF7L2\u3068\u3044\u3063\u305f\u907a\u4f1d\u5b50\u306b\u898b\u3089\u308c\u308b\u5909\u7570\u3084\u3001BCL9\u3001CBP\u3068\u3044\u3063\u305f\u88dc\u52a9\u7684\u306a\u56e0\u5b50\u306e\u8abf\u7bc0\u7570\u5e38\u304c\u3001ASD\u306e\u6839\u672c\u7684\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u6df1\u304f\u95a2\u308f\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u907a\u4f1d\u7684\u5909\u5316\u306f\u3001\u8133\u306e\u767a\u9054\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u3084\u795e\u7d4c\u524d\u99c6\u7d30\u80de\u306e\u5897\u6b96\u3001\u30b7\u30ca\u30d7\u30b9\u306e\u6210\u719f\u306a\u3069\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u3066\u304a\u308a\u3001\u3053\u3046\u3057\u305f\u904e\u7a0b\u306e\u4e71\u308c\u304c\u3001ASD\u306e\u8133\u306b\u898b\u3089\u308c\u308b\u69cb\u9020\u7684\u30fb\u6a5f\u80fd\u7684\u306a\u7279\u5fb4\u306b\u3064\u306a\u304c\u3063\u3066\u3044\u308b\u3068\u7406\u89e3\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%97%87%E7%8A%B6%EF%BD%9CSymptoms\"><\/span>\u75c7\u72b6\uff5cSymptoms<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306e\u8abf\u7bc0\u7570\u5e38\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308bASD\u306e\u75c7\u72b6\u306f\u3001\u591a\u304f\u306e\u5834\u5408\u3001\u795e\u7d4c\u767a\u9054\u3084\u884c\u52d5\u306b\u95a2\u308f\u308b\u3055\u307e\u3056\u307e\u306a\u7570\u5e38\u3068\u3057\u3066\u73fe\u308c\u307e\u3059\u3002\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u7279\u5fb4\u304c\u307f\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u4eba\u306b\u3088\u3063\u3066\u7d44\u307f\u5408\u308f\u305b\u3084\u7a0b\u5ea6\u306f\u7570\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u75c7\u72b6\u306f\u3001\u8208\u596e\u6027\u30cb\u30e5\u30fc\u30ed\u30f3\u3001\u6291\u5236\u6027\u30cb\u30e5\u30fc\u30ed\u30f3\u3001\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u524d\u99c6\u7d30\u80de\u306a\u3069\u3001\u8133\u306e\u3055\u307e\u3056\u307e\u306a\u7d30\u80de\u7cfb\u5217\u306b\u304a\u3051\u308b\u6a5f\u80fd\u4e0d\u5168\u3092\u53cd\u6620\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306f\u3059\u3079\u3066\u3001\u80ce\u5150\u671f\u304b\u3089\u751f\u5f8c\u65e9\u671f\u306e\u767a\u9054\u6bb5\u968e\u306b\u304a\u3044\u3066Wnt\u30b7\u30b0\u30ca\u30eb\u306e\u5f71\u97ff\u3092\u5f37\u304f\u53d7\u3051\u308b\u7d30\u80de\u305f\u3061\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>\u5927\u982d\u75c7\uff08macrocephaly\uff09<\/strong><strong><br><\/strong>CHD8\u306e\u6a5f\u80fd\u55aa\u5931\u3084\u03b2-\u30ab\u30c6\u30cb\u30f3\u306e\u5b89\u5b9a\u5316\u306a\u3069\u306b\u3088\u308a\u3001\u795e\u7d4c\u524d\u99c6\u7d30\u80de\u304c\u904e\u5270\u306b\u5897\u6b96\u3057\u3001\u7d50\u679c\u3068\u3057\u3066\u982d\u56f2\u304c\u5e73\u5747\u3088\u308a\u3082\u5927\u304d\u304f\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306fASD\u3067\u6bd4\u8f03\u7684\u3088\u304f\u898b\u3089\u308c\u308b\u8eab\u4f53\u7684\u7279\u5fb4\u306e\u4e00\u3064\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>\u7e70\u308a\u8fd4\u3057\u306e\u884c\u52d5\u3084\u5e38\u540c\u884c\u52d5<\/strong><strong><br><\/strong>\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001WNT2\u306e\u904e\u5270\u767a\u73fe\u306b\u3088\u3063\u3066\u30c9\u30d1\u30df\u30f3\u7cfb\u306e\u795e\u7d4c\u304c\u904e\u5270\u306b\u767a\u9054\u3057\u3001\u3053\u308c\u306b\u95a2\u9023\u3057\u305f\u53cd\u5fa9\u7684\u306a\u884c\u52d5\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u793e\u4f1a\u7684\u76f8\u4e92\u4f5c\u7528\u306e\u56f0\u96e3<\/strong><strong><br><\/strong>\u6291\u5236\u6027\u30cb\u30e5\u30fc\u30ed\u30f3\u3067\u03b2-\u30ab\u30c6\u30cb\u30f3\u304c\u6b20\u640d\u3057\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u4ed6\u8005\u3068\u306e\u3084\u308a\u3068\u308a\u304c\u56f0\u96e3\u306b\u306a\u308b\u306a\u3069\u3001\u793e\u4f1a\u6027\u306e\u969c\u5bb3\u304c\u89b3\u5bdf\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001ASD\u30e2\u30c7\u30eb\u52d5\u7269\u3067\u3042\u308bBTBR\u30de\u30a6\u30b9\u3067\u306f\u3001DISC1\u3068\u3044\u3046\u907a\u4f1d\u5b50\u306e\u6b20\u640d\u3068\u3068\u3082\u306b\u540c\u69d8\u306e\u50be\u5411\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u8a8d\u77e5\u6a5f\u80fd\u306e\u5909\u5316<\/strong><strong><br><\/strong>\u7269\u4f53\u8a8d\u8b58\u3084\u8a18\u61b6\u306e\u5909\u5316\u3001\u5927\u8133\u76ae\u8cea\u306e\u795e\u7d4c\u56de\u8def\u306e\u5909\u5bb9\u306a\u3069\u304c\u307f\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u30d2\u30c8\u306eASD\u8133\u7d44\u7e54\u3084\u52d5\u7269\u30e2\u30c7\u30eb\u3067\u306f\u3001\u6a39\u72b6\u7a81\u8d77\u30b9\u30d1\u30a4\u30f3\u304c\u904e\u5270\u304b\u3064\u672a\u719f\u306a\u72b6\u614b\u3067\u5b58\u5728\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u89b3\u5bdf\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u5927\u8133\u76ae\u8cea\u306e\u69cb\u9020\u7570\u5e38<\/strong><strong><br><\/strong>ASD\u306e\u60a3\u8005\u3055\u3093\u3067\u306f\u3001\u76ae\u8cea\u306e\u30df\u30cb\u30b3\u30e9\u30e0\uff08\u795e\u7d4c\u7d30\u80de\u306e\u5c0f\u3055\u306a\u7e26\u306e\u5358\u4f4d\uff09\u306e\u69cb\u9020\u7570\u5e38\u3084\u3001\u6d45\u3044\u5c64\u306b\u795e\u7d4c\u7d30\u80de\u304c\u904e\u5270\u306b\u5b58\u5728\u3057\u3001\u6df1\u3044\u5c64\u3067\u306f\u5bc6\u5ea6\u304c\u6e1b\u5c11\u3057\u3066\u3044\u308b\u3068\u3044\u3063\u305f\u5909\u5316\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u3001Wnt\u30b7\u30b0\u30ca\u30eb\u306e\u7570\u5e38\u306b\u3088\u308b\u65e9\u671f\u306e\u76ae\u8cea\u5f62\u6210\u7570\u5e38\u3068\u4e00\u81f4\u3059\u308b\u6240\u898b\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>\u8a00\u8a9e\u306e\u767a\u9054\u306e\u9045\u308c<\/strong><strong><br><\/strong>\u307e\u3060\u9650\u3089\u308c\u305f\u7814\u7a76\u3067\u3059\u304c\u3001\u60a3\u8005\u3055\u3093\u7531\u6765\u306eiPS\u7d30\u80de\uff08\u4eba\u5de5\u591a\u80fd\u6027\u5e79\u7d30\u80de\uff09\u30e2\u30c7\u30eb\u304b\u3089\u5f97\u3089\u308c\u305f\u77e5\u898b\u3067\u306f\u3001Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306e\u6d3b\u6027\u304c\u9ad8\u307e\u3063\u3066\u3044\u308b\u30b1\u30fc\u30b9\u3067\u3001\u8a00\u8a9e\u767a\u9054\u306e\u9045\u308c\u304c\u307f\u3089\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%96%AB%E5%AD%A6%EF%BD%9CEpidemiology\"><\/span>\u75ab\u5b66\uff5cEpidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>ASD\u306f\u3001\u4e16\u754c\u4eba\u53e3\u306e\u304a\u3088\u305d 1\uff5e2\uff05 \u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3068\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u983b\u5ea6\u306f\u56fd\u3084\u5730\u57df\u3001\u8a3a\u65ad\u57fa\u6e96\u3001\u8abf\u67fb\u65b9\u6cd5\u306a\u3069\u306b\u3088\u3063\u3066\u3070\u3089\u3064\u304d\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>ASD\u306f\u3001\u4e00\u822c\u7684\u306b\u7537\u6027\u306b\u591a\u304f\u8a3a\u65ad\u3055\u308c\u308b\u50be\u5411\u304c\u3042\u308a\u3001\u7537\u5973\u6bd4\u306f\u304a\u3088\u305d 4\u5bfe1 \u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u3053\u308c\u306f\u5973\u6027\u306b\u304a\u3051\u308b\u8a3a\u65ad\u306e\u3055\u308c\u306b\u304f\u3055\u304c\u4e00\u56e0\u3068\u8003\u3048\u3089\u308c\u3066\u304a\u308a\u3001\u5973\u6027\u3067\u306f\u3088\u308a\u76ee\u7acb\u3061\u306b\u304f\u3044\u793e\u4f1a\u7684\u30fb\u8a8d\u77e5\u7684\u306a\u7279\u5fb4\u3092\u6301\u3064\u50be\u5411\u3084\u3001\u8a3a\u65ad\u306b\u7d50\u3073\u3064\u304d\u306b\u304f\u3044\u75c7\u72b6\u306e\u8868\u308c\u65b9\u304c\u5f71\u97ff\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u5b9f\u969b\u3001\u5973\u6027\u306eASD\u3067\u306f\u3001\u795e\u7d4c\u767a\u9054\u3092\u8abf\u7bc0\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u306b\u300c\u65b0\u751f\u5909\u7570\uff08de novo mutation\uff09\u300d\u304c\u898b\u3089\u308c\u308b\u983b\u5ea6\u304c\u9ad8\u3044\u3068\u3044\u3046\u5831\u544a\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306b\u95a2\u9023\u3059\u308b\u5909\u7570\u304cASD\u5168\u4f53\u306e\u4e2d\u3067\u3069\u306e\u304f\u3089\u3044\u306e\u5272\u5408\u3092\u5360\u3081\u308b\u304b\u306f\u3001\u73fe\u6642\u70b9\u3067\u660e\u78ba\u306b\u5b9a\u307e\u3063\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u5927\u898f\u6a21\u306a\u30b2\u30ce\u30e0\u7814\u7a76\u3067\u306f\u3001ASD\u306b\u5f37\u304f\u95a2\u9023\u3065\u3051\u3089\u308c\u3066\u3044\u308b\u4e0a\u4f4d102\u500b\u306e\u907a\u4f1d\u5b50\u306e\u3046\u3061\u3001\u7d0459\u500b \u304cWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u3068\u69cb\u9020\u7684\u307e\u305f\u306f\u6a5f\u80fd\u7684\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u3046\u3061\u5c11\u306a\u304f\u3068\u3082 18\u500b\u306e\u907a\u4f1d\u5b50 \u306f\u3001Wnt\u7d4c\u8def\u3092\u6291\u5236\u3059\u308b\u5f79\u5272\u3092\u6301\u3064\u300c\u8ca0\u306e\u8abf\u7bc0\u56e0\u5b50\uff08negative regulators\uff09\u300d\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u4eba\u53e3\u5225\u306e\u89e3\u6790\u304b\u3089\u306f\u3001CHD8\u3001CTNNB1\u3001TCF7L2\u3068\u3044\u3063\u305fWnt\u7d4c\u8def\u306e\u8abf\u7bc0\u56e0\u5b50\u306b\u65b0\u751f\u5909\u7570\u304c\u898b\u3089\u308c\u308bASD\u306e\u75c7\u4f8b\u3067\u306f\u3001\u5927\u982d\u75c7\u3092\u4f34\u3046\u3053\u3068\u304c\u591a\u3044\u3053\u3068\u3084\u3001\u91cd\u75c7\u578b\u306e\u8868\u73fe\u578b\u3092\u6301\u3064\u5973\u6027\u306b\u591a\u304f\u898b\u3089\u308c\u308b\u50be\u5411\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u30011\u6b73\u304b\u30894\u6b73\u306e\u5c0f\u5150ASD\u30b3\u30db\u30fc\u30c8\uff08\u96c6\u56e3\uff09\u3067\u306f\u3001\u672b\u68a2\u8840\u6db2\u4e2d\u306e\u767d\u8840\u7403\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u767a\u73fe\u89e3\u6790\u306b\u304a\u3044\u3066\u3001Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u304c\u9ad8\u307e\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001Wnt\u7d4c\u8def\u306e\u7570\u5e38\u304c\u4e2d\u67a2\u795e\u7d4c\u3060\u3051\u3067\u306a\u304f\u3001\u4f53\u5168\u4f53\u306b\u53ca\u3093\u3067\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u304a\u308a\u3001\u5c06\u6765\u7684\u306b\u306f\u975e\u4fb5\u8972\u7684\u306a\u65b9\u6cd5\u306b\u3088\u308b\u65e9\u671f\u8a3a\u65ad\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"ASD%E3%81%AB%E9%96%A2%E4%B8%8E%E3%81%99%E3%82%8B%E4%B8%BB%E8%A6%81%E9%81%BA%E4%BC%9D%E5%AD%90%EF%BD%9CKey_Genes_Implicated_in_ASD_via_Wnt%CE%B2-Catenin_Pathway\"><\/span>ASD\u306b\u95a2\u4e0e\u3059\u308b\u4e3b\u8981\u907a\u4f1d\u5b50\uff5cKey Genes Implicated in ASD via Wnt\/\u03b2-Catenin Pathway<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>ASD\u306b\u95a2\u9023\u3059\u308b\u3068\u3055\u308c\u308b\u591a\u304f\u306e\u907a\u4f1d\u5b50\u306f\u3001\u76f4\u63a5\u307e\u305f\u306f\u9593\u63a5\u7684\u306bWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306e\u5236\u5fa1\u306b\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306b\u306f\u3001\u8ee2\u5199\u8abf\u7bc0\u3001\u30b7\u30b0\u30ca\u30eb\u53d7\u5bb9\u3001\u5171\u6291\u5236\u56e0\u5b50\u306e\u5236\u5fa1\u3001\u30af\u30ed\u30de\u30c1\u30f3\u518d\u69cb\u6210\u306a\u3069\u3001\u591a\u69d8\u306a\u30ec\u30d9\u30eb\u3067\u306e\u6a5f\u80fd\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001Wnt\u7d4c\u8def\u306e\u6052\u5e38\u6027\u3092\u4fdd\u3064\u4e0a\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4ee5\u4e0b\u306b\u3001\u4e3b\u8981\u306a\u95a2\u9023\u907a\u4f1d\u5b50\u3068\u305d\u306e\u6a5f\u80fd\u7684\u7279\u5fb4\u3092\u307e\u3068\u3081\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<table border=\"1\" cellpadding=\"8\" cellspacing=\"0\" style=\"border-collapse: collapse; font-family: sans-serif; font-size: 14px; width: 100%;\">\n  <thead>\n    <tr>\n      <th>\u907a\u4f1d\u5b50\u540d<\/th>\n      <th>\u67d3\u8272\u4f53\u4f4d\u7f6e<\/th>\n      <th>\u6a5f\u80fd<\/th>\n      <th>\u5909\u7570\u52b9\u679c<\/th>\n      <th>\u5099\u8003<\/th>\n    <\/tr>\n  <\/thead>\n  <tbody>\n    <tr>\n      <td>CHD8<br>(Chromodomain Helicase DNA-binding Protein 8)<\/td>\n      <td>14q11.2<\/td>\n      <td>\u30af\u30ed\u30de\u30c1\u30f3\u69cb\u9020\u306e\u8abf\u6574\u3092\u901a\u3058\u3066\u3001Wnt\u30bf\u30fc\u30b2\u30c3\u30c8\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u6291\u5236\u3002<\/td>\n      <td>\u6a5f\u80fd\u55aa\u5931\u578b\u5909\u7570\uff08LOF\uff09\u306b\u3088\u308a\u3001\u03b2-\u30ab\u30c6\u30cb\u30f3\u4f9d\u5b58\u6027\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u904e\u5270\u306b\u306a\u308a\u3001\u795e\u7d4c\u524d\u99c6\u7d30\u80de\u306e\u904e\u5270\u5897\u6b96\u3068\u5927\u982d\u75c7\uff08macrocephaly\uff09\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002<\/td>\n      <td>\u30de\u30a6\u30b9\u306b\u304a\u3044\u3066\u540c\u69d8\u306e\u8868\u73fe\u578b\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002<\/td>\n    <\/tr>\n    <tr>\n      <td>CTNNB1<br>(Catenin Beta 1\uff0f\u03b2-\u30ab\u30c6\u30cb\u30f3\u907a\u4f1d\u5b50)<\/td>\n      <td>3p22.1<\/td>\n      <td>Wnt\u7d4c\u8def\u306e\u4e2d\u5fc3\u30b7\u30b0\u30ca\u30eb\u5206\u5b50\u3067\u3042\u308a\u3001\u8ee2\u5199\u6d3b\u6027\u5316\u306b\u5fc5\u9808\u3002<\/td>\n      <td>\u5206\u89e3\u3092\u59a8\u3052\u308b\u5909\u7570\u306b\u3088\u308a\u3001\u03b2-\u30ab\u30c6\u30cb\u30f3\u304c\u6838\u306b\u7570\u5e38\u306b\u84c4\u7a4d\u3057\u3001\u76ae\u8cea\u904e\u6210\u9577\u30fb\u795e\u7d4c\u56de\u8def\u306e\u7570\u5e38\u5f62\u6210\u3092\u62db\u304f\u3002<\/td>\n      <td>GABA\u4f5c\u52d5\u6027\u4ecb\u5728\u30cb\u30e5\u30fc\u30ed\u30f3\u3067\u306e\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u306f\u3001\u793e\u4f1a\u7684\u884c\u52d5\u969c\u5bb3\u3084\u8a18\u61b6\u6a5f\u80fd\u306e\u5909\u5316\u3068\u95a2\u9023\u3059\u308b\u3002<\/td>\n    <\/tr>\n    <tr>\n      <td>FZD9<br>(Frizzled Class Receptor 9)<\/td>\n      <td>7q11.23<\/td>\n      <td>Wnt\u30ea\u30ac\u30f3\u30c9\uff08\u7279\u306bWNT2\uff09\u3092\u53d7\u5bb9\u3059\u308bFrizzled\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u4e00\u54e1\u3002<\/td>\n      <td>\u30b3\u30d4\u30fc\u6570\u5909\u7570\uff08CNV\uff09\u3084\u70b9\u5909\u7570\u304c\u3001\u30c9\u30d1\u30df\u30f3\u4f5c\u52d5\u6027\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u767a\u9054\u7570\u5e38\u3068\u5e38\u540c\u884c\u52d5\u306e\u5897\u52a0\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3068\u3055\u308c\u308b\u3002<\/td>\n      <td>\u2014<\/td>\n    <\/tr>\n    <tr>\n      <td>WNT2<br>(Wnt Family Member 2)<\/td>\n      <td>7q31<\/td>\n      <td>Wnt\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u4e00\u54e1\u3067\u3001ASD\u306e\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3067\u9ad8\u983b\u5ea6\u306e\u5909\u7570\u304c\u691c\u51fa\u3055\u308c\u3066\u3044\u308b\u3002<\/td>\n      <td>\u904e\u5270\u767a\u73fe\u306b\u3088\u308a\u3001\u30c9\u30d1\u30df\u30f3\u7cfb\u306e\u904e\u5f62\u6210\u3084\u53cd\u5fa9\u884c\u52d5\u306e\u5897\u52a0\u3068\u95a2\u9023\u3002<\/td>\n      <td>\u2014<\/td>\n    <\/tr>\n    <tr>\n      <td>TCF7L2<br>(Transcription Factor 7 Like 2)<\/td>\n      <td>10q25.2-q25.3<\/td>\n      <td>\u03b2-\u30ab\u30c6\u30cb\u30f3\u3068\u5171\u306b\u50cd\u304fLEF\/TCF\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u8ee2\u5199\u56e0\u5b50\u3002\u76ae\u8cea\u5f62\u6210\u3001\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u5206\u5316\u3001\u8996\u5e8a\u76ae\u8cea\u63a5\u7d9a\u306b\u91cd\u8981\u3002<\/td>\n      <td>ASD\u306b\u95a2\u9023\u3059\u308b\u65b0\u751f\u5909\u7570\uff08de novo variants\uff09\u304c\u8907\u6570\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/td>\n      <td>\u2014<\/td>\n    <\/tr>\n    <tr>\n      <td>BCL9 \u304a\u3088\u3073 CBP<br>(CREBBP)<\/td>\n      <td>1q21.2\u304a\u3088\u307316p13.3<\/td>\n      <td>\u03b2-\u30ab\u30c6\u30cb\u30f3\u3068\u7d50\u5408\u3057\u3066\u8ee2\u5199\u6d3b\u6027\u3092\u4fc3\u9032\u3059\u308b\u5171\u6d3b\u6027\u5316\u56e0\u5b50\u3002<\/td>\n      <td>ASD\u60a3\u8005\u306b\u304a\u3044\u3066\u6b20\u5931\u307e\u305f\u306f\u91cd\u8907\u5909\u7570\u304c\u89b3\u5bdf\u3055\u308c\u3066\u3044\u308b\u3002<\/td>\n      <td>\u2014<\/td>\n    <\/tr>\n    <tr>\n      <td>UBE3A<br>(Ubiquitin Protein Ligase E3A)<\/td>\n      <td>15q11\u2013q13<br>\uff08Angelman\u75c7\u5019\u7fa4\u95a2\u9023\u9818\u57df\uff09<\/td>\n      <td>\u2014<\/td>\n      <td>p.T485A\u5909\u7570\u306b\u3088\u308a\u3001Wnt\u7d4c\u8def\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u3002ASD\u69d8\u306e\u75c7\u72b6\u3092\u4f34\u3046\u8868\u73fe\u578b\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308b\u3002<\/td>\n      <td>\u2014<\/td>\n    <\/tr>\n    <tr>\n      <td>TBL1XR1<br>(Transducin Beta Like 1 X-Linked Receptor 1)<\/td>\n      <td>3q26.32<\/td>\n      <td>\u5171\u6291\u5236\u8907\u5408\u4f53\uff08nuclear co-repressor\uff09\u3092\u4ecb\u3057\u3066\u3001\u03b2-\u30ab\u30c6\u30cb\u30f3\u306e\u8ee2\u5199\u6d3b\u6027\u3092\u8abf\u7bc0\u3002<\/td>\n      <td>Wnt\u306e\u904e\u5270\u6d3b\u6027\u5316\u304a\u3088\u3073ASD\u69d8\u8868\u73fe\u578b\u3068\u306e\u95a2\u9023\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002<\/td>\n      <td>\u2014<\/td>\n    <\/tr>\n    <tr>\n      <td>MED13L<br>(Mediator Complex Subunit 13 Like)<\/td>\n      <td>12q24.21<\/td>\n      <td>\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u8907\u5408\u4f53\u3092\u4ecb\u3057\u3066\u8ee2\u5199\u5236\u5fa1\u306b\u95a2\u4e0e\u3002TBL1XR1\u3068\u5171\u306b\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u7cbe\u5bc6\u306a\u8abf\u6574\u306b\u5bc4\u4e0e\u3002<\/td>\n      <td>ASD\u304a\u3088\u3073\u985e\u7e01\u75be\u60a3\u306b\u95a2\u308f\u308b\u7570\u5e38\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/td>\n      <td>\u2014<\/td>\n    <\/tr>\n  <\/tbody>\n<\/table>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"ASD%E3%81%AE%E7%97%85%E5%9B%A0%EF%BC%9A%E9%81%BA%E4%BC%9D%E7%9A%84%E3%81%8A%E3%82%88%E3%81%B3%E7%92%B0%E5%A2%83%E7%9A%84%E8%A6%81%E5%9B%A0%E3%81%AE%E7%B5%B1%E5%90%88%EF%BD%9CEtiology_of_ASD_Genetic_and_Environmental_Integration\"><\/span>ASD\u306e\u75c5\u56e0\uff1a\u907a\u4f1d\u7684\u304a\u3088\u3073\u74b0\u5883\u7684\u8981\u56e0\u306e\u7d71\u5408\uff5cEtiology of ASD: Genetic and Environmental Integration<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-spectrum-disorder-genetics\/\">\u81ea\u9589\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u75c7<\/a>\uff08ASD\uff09\u306f\u3001\u5358\u4e00\u306e\u539f\u56e0\u3067\u306f\u306a\u304f\u3001\u8907\u6570\u306e\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u56e0\u5b50\u304c\u76f8\u4e92\u306b\u4f5c\u7528\u3059\u308b\u3053\u3068\u3067\u767a\u75c7\u3059\u308b\u591a\u56e0\u5b50\u6027\u306e\u795e\u7d4c\u767a\u9054\u969c\u5bb3\u3067\u3059\u3002\u7279\u306b\u3001ASD\u306b\u304a\u3044\u3066\u4e2d\u5fc3\u7684\u5f79\u5272\u3092\u679c\u305f\u3059\u3068\u3055\u308c\u308b\u30ab\u30ce\u30cb\u30ab\u30ebWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306f\u3001\u305d\u306e\u4e21\u65b9\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u5206\u5b50\u7d4c\u8def\u306e\u3072\u3068\u3064\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%81%BA%E4%BC%9D%E7%9A%84%E3%83%A1%E3%82%AB%E3%83%8B%E3%82%BA%E3%83%A0\"><\/span>\u907a\u4f1d\u7684\u30e1\u30ab\u30cb\u30ba\u30e0<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306e\u8abf\u7bc0\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u7fa4\u306b\u304a\u3044\u3066\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3067ASD\u306e\u75c5\u56e0\u304c\u8aac\u660e\u3055\u308c\u3066\u3044\u307e\u3059\uff1a<\/p>\n\n\n\n<p><strong>CHD8\u306e\u6a5f\u80fd\u55aa\u5931\u578b\u5909\u7570\uff08LOF\uff09<\/strong><br>\u30af\u30ed\u30de\u30c1\u30f3\u518d\u69cb\u6210\u56e0\u5b50CHD8\u306f\u3001\u03b2-\u30ab\u30c6\u30cb\u30f3\u4f9d\u5b58\u6027\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u6291\u5236\u3057\u307e\u3059\u3002\u5909\u7570\u306b\u3088\u308a\u3053\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001Wnt\u7d4c\u8def\u304c\u904e\u5270\u306b\u6d3b\u6027\u5316\u3057\u3001\u795e\u7d4c\u524d\u99c6\u7d30\u80de\u306e\u5897\u6b96\u7570\u5e38\u3068\u5927\u982d\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u3053\u308c\u306fASD\u3067\u89b3\u5bdf\u3055\u308c\u308b\u8133\u904e\u6210\u9577\u3068\u4e00\u81f4\u3057\u307e\u3059\u3002<br><\/p>\n\n\n\n<p><strong>CTNNB1\u306e\u5909\u7570<\/strong><br>\u03b2-\u30ab\u30c6\u30cb\u30f3\u3092\u30b3\u30fc\u30c9\u3059\u308bCTNNB1\u306b\u5909\u7570\u304c\u8d77\u3053\u308b\u3068\u3001\u03b2-\u30ab\u30c6\u30cb\u30f3\u306e\u5206\u89e3\u304c\u59a8\u3052\u3089\u308c\u3001\u7570\u5e38\u306a\u6838\u5185\u84c4\u7a4d\u3068\u8ee2\u5199\u6d3b\u6027\u304c\u751f\u3058\u307e\u3059\u3002\u3053\u308c\u306f\u76ae\u8cea\u904e\u6210\u9577\u3084\u795e\u7d4c\u56de\u8def\u306e\u904e\u5f62\u6210\u3092\u5c0e\u304d\u3001\u793e\u4f1a\u6027\u306e\u969c\u5bb3\u3084\u8a18\u61b6\u6a5f\u80fd\u306e\u5909\u5316\u306b\u3082\u95a2\u4e0e\u3057\u307e\u3059\u3002<br><\/p>\n\n\n\n<p><strong>FZD9\u306eCNV\u3068WNT2\u306e\u904e\u5270\u767a\u73fe<\/strong><br>\u3053\u308c\u3089\u306e\u5909\u7570\u306f\u3001\u30c9\u30d1\u30df\u30f3\u4f5c\u52d5\u6027\u795e\u7d4c\u56de\u8def\u306e\u7570\u5e38\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u7e70\u308a\u8fd4\u3057\u884c\u52d5\uff08repetitive behaviors\uff09\u306e\u5897\u52a0\u306a\u3069\u3001ASD\u306b\u7279\u6709\u306e\u884c\u52d5\u8868\u73fe\u578b\u3068\u95a2\u4fc2\u3057\u307e\u3059\u3002<br><\/p>\n\n\n\n<p><strong>TCF7L2\u3084BCL9\u306a\u3069\u8ee2\u5199\u56e0\u5b50\u306e\u7570\u5e38<\/strong><br>Wnt\u7d4c\u8def\u306e\u4e0b\u6d41\u3067\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u8ee2\u5199\u56e0\u5b50\u306e\u5909\u7570\u306f\u3001\u76ae\u8cea\u5f62\u6210\u3084\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u5206\u5316\u3001\u8996\u5e8a\u76ae\u8cea\u63a5\u7d9a\u306b\u304a\u3044\u3066\u6a5f\u80fd\u969c\u5bb3\u3092\u751f\u3058\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<br><\/p>\n\n\n\n<p><strong>UBE3A\uff08p.T485A\u5909\u7570\uff09\u304a\u3088\u3073TBL1XR1\u306e\u5909\u7570<\/strong><br>\u3053\u308c\u3089\u306f\u7570\u306a\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3067Wnt\u7d4c\u8def\u3092\u904e\u5270\u306b\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001ASD\u306b\u52a0\u3048\u3066Angelman\u75c7\u5019\u7fa4\u306a\u3069\u306e\u95a2\u9023\u795e\u7d4c\u767a\u9054\u75c7\u3067\u3082\u540c\u69d8\u306e\u75c7\u72b6\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br><br><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%92%B0%E5%A2%83%E8%A6%81%E5%9B%A0%E3%81%A8Wnt%E7%B5%8C%E8%B7%AF%E3%81%AE%E6%92%B9%E4%B9%B1\"><\/span>\u74b0\u5883\u8981\u56e0\u3068Wnt\u7d4c\u8def\u306e\u64b9\u4e71<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>ASD\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u74b0\u5883\u56e0\u5b50\u306e\u4e2d\u306b\u306f\u3001\u767a\u9054\u4e2d\u306eWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306b\u76f4\u63a5\u7684\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u52d5\u7269\u5b9f\u9a13\u7b49\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u30d0\u30eb\u30d7\u30ed\u9178\uff08Valproic Acid\uff1aVPA\uff09<\/strong><strong><br><\/strong>\u598a\u5a20\u4e2d\u306eVPA\u66dd\u9732\u306f\u3001\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066WNT1\u304a\u3088\u3073WNT2\u306e\u767a\u73fe\u4e0a\u6607\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001ASD\u69d8\u884c\u52d5\u3068\u795e\u7d4c\u767a\u9054\u7570\u5e38\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002\u30d2\u30c8\u3067\u3082VPA\u66dd\u9732\u3068ASD\u767a\u75c7\u30ea\u30b9\u30af\u3068\u306e\u76f8\u95a2\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br><\/p>\n\n\n\n<p><strong>\u9078\u629e\u7684\u30bb\u30ed\u30c8\u30cb\u30f3\u518d\u53d6\u308a\u8fbc\u307f\u963b\u5bb3\u85ac\uff08SSRIs\uff09<\/strong><br>\u4e00\u90e8\u306e\u6297\u3046\u3064\u85ac\uff08SSRIs\uff09\u306fWnt\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u304a\u308a\u3001\u598a\u5a20\u4e2d\u306e\u4f7f\u7528\u304cASD\u767a\u75c7\u30ea\u30b9\u30af\u3068\u95a2\u4fc2\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3059\u308b\u7814\u7a76\u3082\u5b58\u5728\u3057\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u3053\u308c\u3089\u306e\u77e5\u898b\u306b\u306f\u96c6\u56e3\u5dee\u3084\u4ea4\u7d61\u56e0\u5b50\u304c\u3042\u308b\u305f\u3081\u3001\u614e\u91cd\u306a\u89e3\u91c8\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<br><br><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%B7%8F%E6%8B%AC\"><\/span>\u7dcf\u62ec<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306f\u3001ASD\u306e\u75c5\u614b\u306b\u304a\u3044\u3066\u907a\u4f1d\u5b50\u3068\u74b0\u5883\u306e\u4ea4\u5dee\u70b9\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u7d4c\u8def\u306e\u8abf\u7bc0\u7570\u5e38\u306f\u3001\u795e\u7d4c\u524d\u99c6\u7d30\u80de\u306e\u904e\u5270\u5897\u6b96\u3084\u795e\u7d4c\u63a5\u7d9a\u306e\u7570\u5e38\u3001\u884c\u52d5\u8868\u73fe\u578b\u306e\u591a\u69d8\u6027\u306b\u5927\u304d\u304f\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306a\u77e5\u898b\u306f\u3001ASD\u306e\u7406\u89e3\u3092\u300c\u5358\u306a\u308b\u884c\u52d5\u75c7\u5019\u7fa4\u300d\u304b\u3089\u300c\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u4e2d\u5fc3\u306e\u767a\u9054\u7570\u5e38\u75c7\u5019\u7fa4\u300d\u3078\u3068\u518d\u5b9a\u7fa9\u3059\u308b\u624b\u304c\u304b\u308a\u3068\u306a\u308a\u3001\u500b\u5225\u5316\u533b\u7642\uff08precision medicine\uff09\u3084\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u958b\u767a\u3078\u306e\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%A4%9C%E6%9F%BB%E3%83%BB%E8%A8%BA%E6%96%AD%EF%BD%9CTesting_Diagnosis\"><\/span>\u691c\u67fb\u30fb\u8a3a\u65ad\uff5cTesting &amp; Diagnosis<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-spectrum-disorder-genetics\/\">\u81ea\u9589\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u75c7<\/a>\uff08ASD\uff09\u306e\u8a3a\u65ad\u306f\u3001\u73fe\u5728\u306e\u3068\u3053\u308d\u81e8\u5e8a\u7684\u8a55\u4fa1\u304c\u4e2d\u5fc3\u3067\u884c\u308f\u308c\u3066\u304a\u308a\u3001\u884c\u52d5\u89b3\u5bdf\u3084\u767a\u9054\u6b74\u306b\u57fa\u3065\u304f\u8a73\u7d30\u306a\u8a55\u4fa1\u304c\u7528\u3044\u3089\u308c\u307e\u3059\u3002\u6a19\u6e96\u7684\u306a\u8a3a\u65ad\u30c4\u30fc\u30eb\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ADOS\uff08Autism Diagnostic Observation Schedule\uff09\uff1aASD\u306e\u7279\u6027\u3092\u76f4\u63a5\u89b3\u5bdf\u3059\u308b\u305f\u3081\u306e\u6a19\u6e96\u5316\u3055\u308c\u305f\u884c\u52d5\u8a55\u4fa1<\/li>\n\n\n\n<li>ADI-R\uff08Autism Diagnostic Interview-Revised\uff09\uff1a\u4fdd\u8b77\u8005\u3078\u306e\u30a4\u30f3\u30bf\u30d3\u30e5\u30fc\u3092\u901a\u3058\u3066\u3001\u793e\u4f1a\u6027\u3084\u884c\u52d5\u306e\u7279\u5fb4\u3092\u8a55\u4fa1<\/li>\n<\/ul>\n\n\n\n<div style=\"height:7px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u65b9\u6cd5\u306b\u3088\u3063\u3066\u3001\u793e\u4f1a\u7684\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u306e\u56f0\u96e3\u3055\u3084\u3001\u8208\u5473\u30fb\u884c\u52d5\u306e\u9650\u5b9a\u6027\u30fb\u53cd\u5fa9\u6027\u306a\u3069\u3001ASD\u306e\u4e2d\u6838\u7684\u306a\u7279\u5fb4\u3092\u591a\u89d2\u7684\u306b\u78ba\u8a8d\u3057\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306e\u7570\u5e38\u304cASD\u306b\u6df1\u304f\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u5c06\u6765\u7684\u306b\u306f\u3053\u3046\u3057\u305f\u5206\u5b50\u30ec\u30d9\u30eb\u306e\u6307\u6a19\uff08\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\uff09\u304c\u3001\u5f93\u6765\u306e\u884c\u52d5\u8a55\u4fa1\u3092\u88dc\u5b8c\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u3053\u3067\u306f\u3001\u73fe\u5728\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u691c\u67fb\u624b\u6cd5\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\uff1a<\/p>\n\n\n\n<p><strong>\u672b\u68a2\u8840\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc<\/strong><strong><br><\/strong>1\uff5e4\u6b73\u306eASD\u5150\u306b\u304a\u3051\u308b\u767d\u8840\u7403\uff08\u672b\u68a2\u8840\uff09\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\u3001Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u5316\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u795e\u7d4c\u7d44\u7e54\u3067\u306f\u306a\u3044\u4f53\u306e\u7d30\u80de\u3067\u3082\u30b7\u30b0\u30ca\u30eb\u7570\u5e38\u304c\u53cd\u6620\u3055\u308c\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u975e\u4fb5\u8972\u7684\u304b\u3064\u65e9\u671f\u306b\u691c\u51fa\u53ef\u80fd\u306a\u8a3a\u65ad\u6cd5\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u691c\u67fb<\/strong><strong><br><\/strong>ASD\u306b\u5f37\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u3055\u308c\u308bWnt\u7d4c\u8def\u95a2\u9023\u907a\u4f1d\u5b50\uff08\u4f8b\uff1aCHD8\u3001CTNNB1\u3001TCF7L2\u3001BCL9\u306a\u3069\uff09\u306f\u3001\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\uff08NGS\uff09\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u691c\u67fb\u3084\u3001\u5168\u30a8\u30af\u30bd\u30fc\u30e0\uff0f\u5168\u30b2\u30ce\u30e0\u89e3\u6790\u306e\u5bfe\u8c61\u3068\u3057\u3066\u53d6\u308a\u4e0a\u3052\u3089\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u7279\u306b\u3001\u5927\u982d\u75c7\u3092\u4f34\u3046ASD\u3084\u3001\u305d\u306e\u4ed6\u306e\u75c7\u5019\u3092\u542b\u3080\u300c\u75c7\u5019\u6027ASD\u300d\u306b\u304a\u3044\u3066\u306f\u3001\u907a\u4f1d\u5b50\u8a3a\u65ad\u304c\u6709\u52b9\u306a\u624b\u304c\u304b\u308a\u3068\u306a\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>iPS\u7d30\u80de\u3092\u7528\u3044\u305f\u7d30\u80de\u30e2\u30c7\u30eb<\/strong><strong><br><\/strong>\u60a3\u8005\u3055\u3093\u7531\u6765\u306eiPS\u7d30\u80de\uff08\u4eba\u5de5\u591a\u80fd\u6027\u5e79\u7d30\u80de\uff09\u3092\u795e\u7d4c\u524d\u99c6\u7d30\u80de\u3084\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u5206\u5316\u3055\u305b\u3066\u3001Wnt\u7d4c\u8def\u306e\u6a5f\u80fd\u3092\u76f4\u63a5\u8a55\u4fa1\u3059\u308b\u8a66\u307f\u3082\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u500b\u5225\u306e\u60a3\u8005\u3055\u3093\u3054\u3068\u306e\u75be\u60a3\u306e\u9032\u884c\u3084\u91cd\u75c7\u5ea6\u306e\u7406\u89e3\u304c\u6df1\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u73fe\u6642\u70b9\u3067\u306f\u3001ASD\u306e\u8a3a\u65ad\u306b\u7528\u3044\u308bWnt\u6d3b\u6027\u306e\u81e8\u5e8a\u8a8d\u53ef\u6e08\u307f\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306f\u5b58\u5728\u3057\u3066\u3044\u307e\u305b\u3093\u304c\u3001Wnt\u7d4c\u8def\u306e\u4ee3\u8868\u7684\u306a\u8ee2\u5199\u6a19\u7684\u3067\u3042\u308bAxin2\u306a\u3069\u304c\u3001\u8a3a\u65ad\u30de\u30fc\u30ab\u30fc\u5019\u88dc\u3068\u3057\u3066\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u3084\u76ae\u8cea\u7d44\u7e54\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u30d1\u30bf\u30fc\u30f3\u3082\u3001\u5c06\u6765\u7684\u306b\u8a3a\u65ad\u3084\u4e88\u5f8c\u4e88\u6e2c\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%B2%BB%E7%99%82%E6%B3%95%E3%81%A8%E7%AE%A1%E7%90%86%EF%BD%9CTreatment_Management\"><\/span>\u6cbb\u7642\u6cd5\u3068\u7ba1\u7406\uff5cTreatment &amp; Management<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u73fe\u5728\u306e\u3068\u3053\u308d\u3001Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u3092\u76f4\u63a5\u7684\u306b\u6a19\u7684\u3068\u3059\u308bASD\u6cbb\u7642\u85ac\u306f\u3001\u7c73\u56fd\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff08FDA\uff09\u306b\u3088\u3063\u3066\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u52d5\u7269\u30e2\u30c7\u30eb\u3084\u524d\u81e8\u5e8a\u7814\u7a76\u3067\u306f\u3001\u3053\u306e\u7d4c\u8def\u306e\u6d3b\u52d5\u3092\u8abf\u6574\u3059\u308b\u3053\u3068\u306b\u3088\u308aASD\u306e\u75c7\u72b6\u3092\u90e8\u5206\u7684\u306b\u6539\u5584\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4ee5\u4e0b\u306f\u3001\u7814\u7a76\u6bb5\u968e\u3067\u691c\u8a0e\u3055\u308c\u3066\u3044\u308b\u6cbb\u7642\u6226\u7565\u306e\u6982\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%B5%8C%E8%B7%AF%E6%8A%91%E5%88%B6%E8%96%AC%EF%BC%88Pathway_Inhibitors%EF%BC%89\"><\/span>\u7d4c\u8def\u6291\u5236\u85ac\uff08Pathway Inhibitors\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u304c\u904e\u5270\u306b\u6d3b\u6027\u5316\u3057\u3066\u3044\u308b\u30bf\u30a4\u30d7\u306eASD\u3067\u306f\u3001\u305d\u306e\u6d3b\u52d5\u3092\u6291\u3048\u308b\u3053\u3068\u3067\u75c7\u72b6\u304c\u6539\u5584\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Tankyrase\u963b\u5bb3\u85ac\uff08\u4f8b\uff1aXAV939\uff09<\/strong><br>\u03b2-\u30ab\u30c6\u30cb\u30f3\u306e\u5206\u89e3\u3092\u4fc3\u9032\u3059\u308b\u300c\u7834\u58ca\u8907\u5408\u4f53\u300d\u3092\u5b89\u5b9a\u5316\u3055\u305b\u3001Wnt\u30b7\u30b0\u30ca\u30eb\u3092\u6291\u5236\u3057\u307e\u3059\u3002\u52d5\u7269\u30e2\u30c7\u30eb\u3067\u306f\u3001\u3053\u306e\u85ac\u5264\u3092\u4f7f\u3063\u3066ASD\u69d8\u884c\u52d5\u3092\u518d\u73fe\u3059\u308b\u5b9f\u9a13\u3082\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>Porcupine\u963b\u5bb3\u85ac\uff08\u4f8b\uff1aLGK974\/WNT974\uff09<\/strong><br>Wnt\u30ea\u30ac\u30f3\u30c9\u306e\u5206\u6ccc\u3092\u59a8\u3052\u308b\u3053\u3068\u3067\u3001\u7d4c\u8def\u5168\u4f53\u306e\u6d3b\u6027\u3092\u6291\u3048\u307e\u3059\u3002\u73fe\u5728\u306f\u304c\u3093\u6cbb\u7642\u85ac\u3068\u3057\u3066\u81e8\u5e8a\u8a66\u9a13\u4e2d\u3067\u3059\u304c\u3001\u5c06\u6765\u7684\u306bASD\u3078\u306e\u5fdc\u7528\u3082\u691c\u8a0e\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u0392-\u30ab\u30c6\u30cb\u30f3\u3068\u5171\u6d3b\u6027\u5316\u56e0\u5b50\u306e\u7d50\u5408\u963b\u5bb3\u85ac<\/strong><br>CBP\/p300\u3001BCL9\u3001TCF\u306a\u3069\u3068\u306e\u7d50\u5408\u3092\u59a8\u3052\u3001\u7570\u5e38\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:7px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%B5%8C%E8%B7%AF%E6%B4%BB%E6%80%A7%E5%8C%96%E8%96%AC%EF%BC%88Pathway_Activators%EF%BC%89\"><\/span>\u7d4c\u8def\u6d3b\u6027\u5316\u85ac\uff08Pathway Activators\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Wnt\u30b7\u30b0\u30ca\u30eb\u304c\u904e\u5c11\u3067\u3042\u308b\u5834\u5408\u3001\u3053\u306e\u7d4c\u8def\u3092\u9069\u5207\u306b\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u6a5f\u80fd\u3084\u30b7\u30ca\u30d7\u30b9\u5f62\u6210\u3092\u56de\u5fa9\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30c1\u30a6\u30e0<\/strong><br>GSK-3\u03b2\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u3001\u03b2-\u30ab\u30c6\u30cb\u30f3\u306e\u5b89\u5b9a\u6027\u3092\u9ad8\u3081\u307e\u3059\u3002\u3082\u3068\u3082\u3068\u306f\u53cc\u6975\u6027\u969c\u5bb3\u306e\u6cbb\u7642\u85ac\u3067\u3059\u304c\u3001\u795e\u7d4c\u7d30\u80de\u3078\u306eWnt\u30b7\u30b0\u30ca\u30eb\u6d3b\u6027\u306b\u3082\u5f71\u97ff\u3057\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u30d0\u30eb\u30d7\u30ed\u9178\uff08VPA\uff09<\/strong><br>WNT1\u3084WNT2\u306e\u767a\u73fe\u3092\u9ad8\u3081\u308b\u4f5c\u7528\u304c\u3042\u308a\u3001\u598a\u5a20\u4e2d\u306e\u66dd\u9732\u306fASD\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u307e\u3059\u304c\u3001\u5225\u306e\u6587\u8108\u3067\u306f\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\uff08HDAC\uff09\u963b\u5bb3\u4f5c\u7528\u306b\u3088\u308a\u795e\u7d4c\u65b0\u751f\u3092\u4fc3\u3059\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>CHIR99021<\/strong><br>GSK-3\u03b2\u3092\u9078\u629e\u7684\u306b\u963b\u5bb3\u3059\u308b\u85ac\u5264\u3067\u3001\u30c9\u30d1\u30df\u30f3\u795e\u7d4c\u306e\u767a\u9054\u3092\u4fc3\u3059\u3053\u3068\u304c\u52d5\u7269\u5b9f\u9a13\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>SSRI\uff08\u9078\u629e\u7684\u30bb\u30ed\u30c8\u30cb\u30f3\u518d\u53d6\u308a\u8fbc\u307f\u963b\u5bb3\u85ac\uff09<\/strong><br>Wnt\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3059\u308b\u4f5c\u7528\u304c\u8a66\u9a13\u7ba1\u5185\u3067\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u598a\u5a20\u4e2d\u306e\u4f7f\u7528\u3068ASD\u30ea\u30b9\u30af\u306e\u95a2\u9023\u6027\u304c\u4e00\u90e8\u306e\u96c6\u56e3\u3067\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u614e\u91cd\u306a\u691c\u8a0e\u304c\u5fc5\u8981\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%81%9D%E3%81%AE%E4%BB%96%E3%81%AE%E8%AA%BF%E7%AF%80%E5%9B%A0%E5%AD%90\"><\/span>\u305d\u306e\u4ed6\u306e\u8abf\u7bc0\u56e0\u5b50<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30a4\u30de\u30c1\u30cb\u30d6\uff08Imatinib\uff09\uff1a\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u85ac\u3067\u3042\u308a\u3001Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u3001\u884c\u52d5\u3084\u795e\u7d4c\u6a5f\u80fd\u306e\u6539\u5584\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br><\/li>\n\n\n\n<li>\u30ec\u30c1\u30ce\u30a4\u30f3\u9178\uff08RA\uff09\u3084Hedgehog\u7d4c\u8def\u306e\u8abf\u7bc0\u85ac\uff1aWnt\u7d4c\u8def\u3068\u76f8\u4e92\u4f5c\u7528\u3092\u6301\u3061\u3001\u4f75\u7528\u7642\u6cd5\u306e\u5019\u88dc\u3068\u3057\u3066\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%87%A8%E5%BA%8A%E3%81%AB%E3%81%8A%E3%81%91%E3%82%8B%E7%95%99%E6%84%8F%E7%82%B9\"><\/span>\u81e8\u5e8a\u306b\u304a\u3051\u308b\u7559\u610f\u70b9<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u73fe\u6642\u70b9\u3067\u306f\u3001ASD\u3092\u5bfe\u8c61\u3068\u3057\u305fWnt\u7d4c\u8def\u6a19\u7684\u6cbb\u7642\u85ac\u306e\u81e8\u5e8a\u8a66\u9a13\u306f\u5b9f\u65bd\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002Wnt\u7d4c\u8def\u306f\u3001\u767a\u9054\u4e2d\u306e\u81d3\u5668\u3084\u7d44\u7e54\u306e\u6052\u5e38\u6027\u306b\u3082\u95a2\u4e0e\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u6cbb\u7642\u306e\u9069\u7528\u306b\u306f\u6642\u671f\u3084\u6a19\u7684\u7d44\u7e54\u3092\u9650\u5b9a\u3057\u305f\u7cbe\u5bc6\u306a\u8a2d\u8a08\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u80cc\u666f\u304b\u3089\u3001\u500b\u5225\u5316\u533b\u7642\uff08personalized medicine\uff09\u306e\u91cd\u8981\u6027\u304c\u9ad8\u307e\u3063\u3066\u304a\u308a\u3001Wnt\u7d4c\u8def\u306e\u6d3b\u6027\u72b6\u614b\u3084\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8a55\u4fa1\u3057\u305f\u4e0a\u3067\u85ac\u5264\u3092\u9078\u629e\u3059\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u3001\u4eca\u5f8c\u5fc5\u8981\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E4%BA%88%E5%BE%8C%EF%BD%9CPrognosis\"><\/span>\u4e88\u5f8c\uff5cPrognosis<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-spectrum-disorder-genetics\/\">\u81ea\u9589\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u75c7<\/a>\uff08ASD\uff09\u306e\u4e88\u5f8c\uff08\u5c06\u6765\u306e\u898b\u901a\u3057\uff09\u306f\u3001\u75c7\u72b6\u306e\u91cd\u3055\u3001\u767a\u9054\u306e\u6bb5\u968e\u3067\u306e\u65e9\u671f\u4ecb\u5165\u306e\u6709\u7121\u3001\u305d\u3057\u3066\u4f75\u5b58\u3059\u308b\u533b\u5b66\u7684\u30fb\u767a\u9054\u7684\u306a\u72b6\u614b\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u8981\u56e0\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4eca\u56de\u3054\u7d39\u4ecb\u3057\u3066\u3044\u308b\u6587\u732e\u3067\u306f\u3001Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306e\u5909\u7570\u306b\u76f4\u63a5\u7d50\u3073\u3064\u3044\u305f\u9577\u671f\u7684\u306a\u4e88\u5f8c\u30c7\u30fc\u30bf\u306f\u307e\u3060\u5341\u5206\u306b\u84c4\u7a4d\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u3044\u304f\u3064\u304b\u306e\u91cd\u8981\u306a\u77e5\u898b\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305a\u3001CHD8\u5909\u7570\u306a\u3069\u306b\u3088\u3063\u3066Wnt\u6d3b\u6027\u304c\u9ad8\u307e\u3063\u3066\u3044\u308b\u5834\u5408\u3001\u5927\u982d\u75c7\u306e\u51fa\u73fe\u3084\u3088\u308a\u65e9\u671f\u306eASD\u75c7\u72b6\u306e\u767a\u73fe\u3001\u3055\u3089\u306b\u300c\u75c7\u5019\u6027ASD\uff08syndromic ASD\uff09\u300d\u3068\u3057\u3066\u306e\u8a3a\u65ad\u306b\u81f3\u308b\u30b1\u30fc\u30b9\u304c\u591a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30b1\u30fc\u30b9\u3067\u306f\u3001\u3088\u308a\u8907\u96d1\u306a\u81e8\u5e8a\u7d4c\u904e\u3092\u305f\u3069\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u7d99\u7d9a\u7684\u304b\u3064\u500b\u5225\u5316\u3055\u308c\u305f\u652f\u63f4\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001Wnt\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u65b9\u3005\u3067\u306f\u3001\u75c7\u72b6\u306e\u3042\u3089\u308f\u308c\u65b9\u306b\u5e45\u304c\u3042\u308a\u3001\u305d\u308c\u306b\u5fdc\u3058\u3066\u6cbb\u7642\u3078\u306e\u53cd\u5fdc\u306b\u3082\u9055\u3044\u304c\u751f\u3058\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u7279\u5b9a\u306e\u7d4c\u8def\u5206\u5b50\u306b\u4f5c\u7528\u3059\u308b\u85ac\u5264\u304c\u3001\u6709\u52b9\u6027\u3092\u793a\u3059\u30b1\u30fc\u30b9\u3068\u305d\u3046\u3067\u306a\u3044\u30b1\u30fc\u30b9\u304c\u5b58\u5728\u3057\u3001\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u500b\u5225\u8a3a\u65ad\u3084\u6cbb\u7642\u306e\u6700\u9069\u5316\u304c\u3001\u4eca\u5f8c\u307e\u3059\u307e\u3059\u91cd\u8981\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u52d5\u7269\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u7814\u7a76\u3067\u306f\u3001Wnt\u7d4c\u8def\u3092\u8abf\u6574\u3059\u308b\u85ac\u5264\uff08\u4f8b\uff1aGSK-3\u03b2\u963b\u5bb3\u85ac\uff09\u3092\u767a\u9054\u306e\u65e9\u3044\u6642\u671f\u306b\u6295\u4e0e\u3059\u308b\u3053\u3068\u3067\u3001ASD\u306b\u985e\u4f3c\u3057\u305f\u884c\u52d5\u3084\u795e\u7d4c\u5b66\u7684\u7570\u5e38\u304c\u4e00\u90e8\u56de\u5fa9\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u9069\u5207\u306a\u6642\u671f\u306b\u4ecb\u5165\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u767a\u9054\u306e\u6d41\u308c\u3092\u5909\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u65e9\u671f\u8a3a\u65ad\u3068\u652f\u63f4\u306e\u91cd\u8981\u6027\u3092\u88cf\u3065\u3051\u308b\u7d50\u679c\u3068\u3044\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001Wnt\u7d4c\u8def\u306e\u6d3b\u6027\u72b6\u614b\u3092\u53cd\u6620\u3059\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\uff08\u4f8b\uff1aAxin2\u306e\u767a\u73fe\u3084\u3001\u767d\u8840\u7403\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306a\u3069\uff09\u304c\u5c06\u6765\u7684\u306b\u500b\u5225\u306e\u4e88\u5f8c\u4e88\u6e2c\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u3082\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u3088\u308a\u7cbe\u5bc6\u306a\u652f\u63f4\u8a08\u753b\u306e\u7acb\u6848\u304c\u53ef\u80fd\u306b\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5168\u4f53\u3068\u3057\u3066\u3001Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306e\u8abf\u7bc0\u7570\u5e38\u306f\u3001ASD\u306e\u80cc\u666f\u306b\u3042\u308b\u4e00\u8cab\u3057\u305f\u3001\u304b\u3064\u751f\u7269\u5b66\u7684\u306b\u3082\u3063\u3068\u3082\u3089\u3057\u3044\u8981\u56e0\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u308c\u304c\u500b\u3005\u306e\u9577\u671f\u7684\u306a\u7d4c\u904e\u306b\u3069\u306e\u3088\u3046\u306b\u5f71\u97ff\u3059\u308b\u304b\u306b\u3064\u3044\u3066\u306f\u3001\u4eca\u3082\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u308b\u6bb5\u968e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u73fe\u5728\u5f97\u3089\u308c\u3066\u3044\u308b\u77e5\u898b\u306f\u3001ASD\u306e\u65e9\u671f\u767a\u898b\u3068\u4ecb\u5165\u306e\u91cd\u8981\u6027\u3001\u305d\u3057\u3066\u305d\u308c\u305e\u308c\u306e\u65b9\u306e\u907a\u4f1d\u7684\u30fb\u5206\u5b50\u7684\u7279\u5fb4\u306b\u5408\u308f\u305b\u305f\u304d\u3081\u7d30\u3084\u304b\u306a\u652f\u63f4\u306e\u5fc5\u8981\u6027\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u79c1\u305f\u3061\u304c\u4eca\u5f8c\u306e\u30b1\u30a2\u3092\u3088\u308a\u826f\u3044\u3082\u306e\u306b\u3057\u3066\u3044\u304f\u305f\u3081\u306e\u5927\u5207\u306a\u9053\u3057\u308b\u3079\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%BC%95%E7%94%A8%E6%96%87%E7%8C%AE%EF%BD%9CReferences\"><\/span>\u5f15\u7528\u6587\u732e\uff5cReferences<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"591\" src=\"\/nipt\/wp-content\/uploads\/2025\/07\/Screenshot-2025-07-18-155804-1024x591.jpg\" alt=\"Wnt signaling pathways.\n\nIn the \u03b2-catenin-dependent pathway, Wnt is considered \u2018off\u2019 when Wnt is not bound to FZD receptors and LRP5\/6 co-receptors. \u03b2-catenin associates with the destruction complex (APC, Axin, CK1, GSK33), where it is phosphorylated by GSK-3 and CK1, followed by subsequent degradation via the proteasome. Wnt is considered \u2018on\u2019 when a Wnt ligand binds to LRP5\/6 and FZD receptors, and the scaffold protein Dvl recruits Axin along with the kinases CK1 and GSK-3 to the membrane. This disrupts the formation of the destruction complex, preventing the phosphorylation and degradation of \u03b2-catenin. As a result, \u03b2-catenin accumulates in the cytoplasm and then translocates to the nucleus, where it activates transcription of Wnt target genes. In the Wnt\/PCP pathway, small G proteins RhoA and RAC are activated via Dvl, resulting in signaling via the ROCK and Jnk signaling pathways. In the Wnt\/Ca2+ signaling pathway, signaling is via heterotrimeric G proteins that activate PLC, which leads to a rise in intracellular Ca2+. This leads to the activation of calcineurin (Ca), calcium\/calmodulin-dependent kinase II (CamKII), and PKC. Both CamKII and PKC activate various regulatory proteins such as NF-\u03baB and CREB, and Cn can activate the cytoplasmic protein NFAT. CamKII, calcium\/calmodulin-dependent kinase II; Wnt, wingless\/integrated.\n\nPascual, Danielle M., et al. \u2018Excess Wnt in Neurological Disease\u2019. Biochemical Journal, vol. 482, no. 10, May 2025, pp. 601\u201318. DOI.org (Crossref), https:\/\/doi.org\/10.1042\/BCJ20240265.\" class=\"wp-image-106186\"\/><\/figure>\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1007\/s10571-020-00882-7\">Baranova, J., Dragunas, G., Botellho, M.C.S. et al. Autism Spectrum Disorder: Signaling Pathways and Prospective Therapeutic Targets. Cell Mol Neurobiol 41, 619\u2013649 (2021). https:\/\/doi.org\/10.1007\/s10571-020-00882-7<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/biology14020185\">Nadin, Silvina B., et al. \u2018Overview of Wnt\/\u03b2-Catenin Pathway and DNA Damage\/Repair in Cancer\u2019. Biology, vol. 14, no. 2, Feb. 2025, p. 185. DOI.org (Crossref), https:\/\/doi.org\/10.3390\/biology14020185.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.cell.2012.05.012\">Clevers, Hans, and Roel Nusse. \u2018Wnt\/\u03b2-Catenin Signaling and Disease\u2019. Cell, vol. 149, no. 6, Jun. 2012, pp. 1192\u2013205. DOI.org (Crossref), https:\/\/doi.org\/10.1016\/j.cell.2012.05.012.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.devcel.2009.06.016\">MacDonald, B. T., Tamai, K., &amp; He, X. (2009). Wnt\/beta-catenin signaling: components, mechanisms, and diseases. Developmental cell, 17(1), 9\u201326. https:\/\/doi.org\/10.1016\/j.devcel.2009.06.016<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1177\/1073858420914509\">Gao, Juanmei, et al. \u2018Wnt\/\u03b2-Catenin Signaling in Neural Stem Cell Homeostasis and Neurological Diseases\u2019. The Neuroscientist, vol. 27, no. 1, Feb. 2021, pp. 58\u201372. DOI.org (Crossref), https:\/\/doi.org\/10.1177\/1073858420914509.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1042\/BCJ20240265\">Pascual, Danielle M., et al. \u2018Excess Wnt in Neurological Disease\u2019. Biochemical Journal, vol. 482, no. 10, May 2025, pp. 601\u201318. DOI.org (Crossref), https:\/\/doi.org\/10.1042\/BCJ20240265.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3389\/fnmol.2021.764756\">Caracci, Mario O., et al. \u2018Wnt\/\u03b2-Catenin-Dependent Transcription in Autism Spectrum Disorders\u2019. Frontiers in Molecular Neuroscience, vol. 14, Nov. 2021, p. 764756. DOI.org (Crossref), https:\/\/doi.org\/10.3389\/fnmol.2021.764756.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/cells10040958\">Upadhyay, Jyoti, et al. \u2018Dysregulation of Multiple Signaling Neurodevelopmental Pathways during Embryogenesis: A Possible Cause of Autism Spectrum Disorder\u2019. Cells, vol. 10, no. 4, Apr. 2021, p. 958. DOI.org (Crossref), https:\/\/doi.org\/10.3390\/cells10040958.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41392-021-00762-6\">Liu, J., Xiao, Q., Xiao, J. <em>et al.<\/em> Wnt\/\u03b2-catenin signalling: function, biological mechanisms, and therapeutic opportunities. <em>Sig Transduct Target Ther<\/em> 7, 3 (2022). https:\/\/doi.org\/10.1038\/s41392-021-00762-6<\/a><\/li>\n<\/ul>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<!-- \u3042\u3044\u3046\u3048\u304a\u304b\u304d\u304f\u3051\u3053\u3055\u3057\u3059\u305b\u305d\u305f\u3061\u3064\u3066\u3068-->\n\n<script type=\"application\/ld+json\">\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@graph\": [\n    {\n      \"@type\": \"WebPage\",\n      \"@id\": \"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\",\n      \"url\": \"https:\/\/www.hiro-clinic.or.jp\/nipt\/asd-wnt-canonical-pathway-overview\",\n      \"name\": 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