{"id":108115,"date":"2025-07-29T12:33:13","date_gmt":"2025-07-29T03:33:13","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/?p=108115"},"modified":"2025-08-04T15:17:08","modified_gmt":"2025-08-04T06:17:08","slug":"autism-maternal-nutrition","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-maternal-nutrition\/","title":{"rendered":"\u81ea\u9589\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u75c7\uff08ASD\uff09\u306e\u767a\u75c7\u306b\u5f71\u97ff\u3059\u308b\u6bcd\u4f53\u306e\u6804\u990a\u72b6\u614b\u3068\u306f\uff1f\u598a\u5a20\u671f\u306e\u98df\u4e8b\u3068\u75c5\u56e0\u3092\u3081\u3050\u308b\u6700\u65b0\u7814\u7a76\u3088\u308a"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<div style=\"border: 4px solid #80c1ea; background-color: #f8fcff; border-radius: 12px; padding: 1.5rem; margin: 1.5rem 0 2.5rem; font-family: 'Helvetica Neue', sans-serif; line-height: 1.6; box-shadow: 0 2px 8px rgba(0, 0, 0, 0.04);\">\n<div id=\"ez-toc-container\" 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href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-maternal-nutrition\/#%E3%83%93%E3%82%BF%E3%83%9F%E3%83%B3D%EF%BC%88Vitamin_D%EF%BC%89%EF%BC%9A%E5%A4%AA%E9%99%BD%E3%81%AE%E3%83%93%E3%82%BF%E3%83%9F%E3%83%B3%E3%81%8C%E6%94%AF%E3%81%88%E3%82%8B%E3%80%81%E7%99%BA%E9%81%94%E3%81%AE%E5%9C%9F%E5%8F%B0\" >\u30d3\u30bf\u30df\u30f3D\uff08Vitamin D\uff09\uff1a\u592a\u967d\u306e\u30d3\u30bf\u30df\u30f3\u304c\u652f\u3048\u308b\u3001\u767a\u9054\u306e\u571f\u53f0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-maternal-nutrition\/#%E3%82%AA%E3%83%A1%E3%82%AC3%E8%84%82%E8%82%AA%E9%85%B8%EF%BC%88Omega-3_Fatty_Acids%EF%BC%89%EF%BC%9A%E7%A5%9E%E7%B5%8C%E3%81%AE%E7%99%BA%E9%81%94%E3%81%AB%E6%AC%A0%E3%81%8B%E3%81%9B%E3%81%AA%E3%81%84%E8%84%82%E8%B3%AA%E3%81%AE%E5%83%8D%E3%81%8D\" >\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff08Omega-3 Fatty Acids\uff09\uff1a\u795e\u7d4c\u306e\u767a\u9054\u306b\u6b20\u304b\u305b\u306a\u3044\u8102\u8cea\u306e\u50cd\u304d<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-maternal-nutrition\/#%E9%AB%98%E8%84%82%E8%82%AA%E9%A3%9F%EF%BC%88High-Fat_Diet%EF%BC%89%EF%BC%9A%E6%AF%8D%E4%BD%93%E3%81%AE%E9%A3%9F%E4%BA%8B%E3%81%8C%E8%84%B3%E3%81%AB%E4%B8%8E%E3%81%88%E3%82%8B%E5%BD%B1%E9%9F%BF\" >\u9ad8\u8102\u80aa\u98df\uff08High-Fat Diet\uff09\uff1a\u6bcd\u4f53\u306e\u98df\u4e8b\u304c\u8133\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-maternal-nutrition\/#%E5%A6%8A%E5%A8%A0%E7%94%A8%E3%83%93%E3%82%BF%E3%83%9F%E3%83%B3%E3%81%A8%E3%83%9E%E3%83%AB%E3%83%81%E3%83%93%E3%82%BF%E3%83%9F%E3%83%B3%EF%BC%88Prenatal_and_Multivitamin_Supplements%EF%BC%89%EF%BC%9A%E9%81%8E%E4%B8%8D%E8%B6%B3%E3%81%AA%E3%81%8F%E3%80%81%E3%83%90%E3%83%A9%E3%83%B3%E3%82%B9%E3%82%92%E6%84%8F%E8%AD%98%E3%81%97%E3%81%A6\" >\u598a\u5a20\u7528\u30d3\u30bf\u30df\u30f3\u3068\u30de\u30eb\u30c1\u30d3\u30bf\u30df\u30f3\uff08Prenatal and Multivitamin Supplements\uff09\uff1a\u904e\u4e0d\u8db3\u306a\u304f\u3001\u30d0\u30e9\u30f3\u30b9\u3092\u610f\u8b58\u3057\u3066<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-maternal-nutrition\/#%E3%81%9D%E3%81%AE%E4%BB%96%E3%81%AE%E6%A0%84%E9%A4%8A%E7%B4%A0%E3%81%A8%E3%81%9D%E3%81%AE%E5%BD%B1%E9%9F%BF\" 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href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-maternal-nutrition\/#%E3%83%97%E3%83%AD%E3%83%90%E3%82%A4%E3%82%AA%E3%83%86%E3%82%A3%E3%82%AF%E3%82%B9%E3%81%A8%E8%85%B8%E2%80%93%E8%84%B3%E8%BB%B8%EF%BC%88Gut_Microbiota_and_the_Gut%E2%80%93Brain_Axis%EF%BC%89%EF%BC%9A%E3%81%8A%E8%85%B9%E3%81%AE%E5%81%A5%E5%BA%B7%E3%81%A8%E5%BF%83%E3%81%AE%E3%81%A4%E3%81%AA%E3%81%8C%E3%82%8A\" >\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u3068\u8178\u2013\u8133\u8ef8\uff08Gut Microbiota and the Gut\u2013Brain Axis\uff09\uff1a\u304a\u8179\u306e\u5065\u5eb7\u3068\u5fc3\u306e\u3064\u306a\u304c\u308a<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-maternal-nutrition\/#%E4%BA%88%E5%BE%8C%EF%BD%9CPrognosis\" >\u4e88\u5f8c\uff5cPrognosis<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-maternal-nutrition\/#%E5%B0%8F%E3%81%95%E3%81%AA%E7%A9%8D%E3%81%BF%E9%87%8D%E3%81%AD%E3%81%8C%E6%9C%AA%E6%9D%A5%E3%82%92%E3%81%A4%E3%81%8F%E3%82%8B\" >\u5c0f\u3055\u306a\u7a4d\u307f\u91cd\u306d\u304c\u672a\u6765\u3092\u3064\u304f\u308b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-maternal-nutrition\/#%E3%82%88%E3%81%8F%E8%A6%8B%E3%82%89%E3%82%8C%E3%82%8B%E7%A0%94%E7%A9%B6%E4%B8%8A%E3%81%AE%E9%99%90%E7%95%8C%EF%BC%88Common_Limitations%EF%BC%89%EF%BC%9A%E7%9F%A5%E3%82%8B%E3%81%93%E3%81%A8%E3%81%AE%E5%A4%A7%E5%88%87%E3%81%95%E3%80%81%E9%99%90%E7%95%8C%E3%82%92%E7%9F%A5%E3%82%8B%E3%81%93%E3%81%A8%E3%81%AE%E8%AC%99%E8%99%9A%E3%81%95\" >\u3088\u304f\u898b\u3089\u308c\u308b\u7814\u7a76\u4e0a\u306e\u9650\u754c\uff08Common Limitations\uff09\uff1a\u77e5\u308b\u3053\u3068\u306e\u5927\u5207\u3055\u3001\u9650\u754c\u3092\u77e5\u308b\u3053\u3068\u306e\u8b19\u865a\u3055<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-maternal-nutrition\/#%E4%BB%8A%E5%BE%8C%E3%81%AE%E7%A0%94%E7%A9%B6%E8%AA%B2%E9%A1%8C%EF%BC%88Future_Research_Priorities%EF%BC%89%EF%BC%9A%E3%81%93%E3%82%8C%E3%81%8B%E3%82%89%E3%81%AE%E5%B8%8C%E6%9C%9B%E3%82%92%E7%A7%91%E5%AD%A6%E3%81%AB%E3%81%A4%E3%81%AA%E3%81%90\" >\u4eca\u5f8c\u306e\u7814\u7a76\u8ab2\u984c\uff08Future Research Priorities\uff09\uff1a\u3053\u308c\u304b\u3089\u306e\u5e0c\u671b\u3092\u79d1\u5b66\u306b\u3064\u306a\u3050<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-maternal-nutrition\/#%E5%BC%95%E7%94%A8%E6%96%87%E7%8C%AE%EF%BD%9CReferences\" >\u5f15\u7528\u6587\u732e\uff5cReferences<\/a><\/li><\/ul><\/nav><\/div>\n<h2 style=\"margin-top: 0; margin-bottom: 0.75rem; font-size: 1.25rem; color: #2a79b8; text-align: left; border-bottom: 2px solid #a6cbdc; padding-bottom: 0.25rem;\"><span class=\"ez-toc-section\" id=\"%E3%82%84%E3%81%95%E3%81%97%E3%81%84%E3%81%BE%E3%81%A8%E3%82%81\"><\/span>\n  \u3084\u3055\u3057\u3044\u307e\u3068\u3081\n<span class=\"ez-toc-section-end\"><\/span><\/h2>\n  <p style=\"margin: 0; font-size: 1rem; color: #333;\">\n    <div>\n  <p>\n    <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-spectrum-disorder-genetics\/\">\u81ea\u9589\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u75c7<\/a>\uff08Autism Spectrum Disorder, ASD\uff09\u306f\u3001\u5bfe\u4eba\u95a2\u4fc2\u3084\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u306e\u96e3\u3057\u3055\u3001\u53cd\u5fa9\u7684\u306a\u884c\u52d5\u306a\u3069\u3092\u7279\u5fb4\u3068\u3059\u308b\u795e\u7d4c\u767a\u9054\u75c7\u3067\u3059\u3002\u539f\u56e0\u306f\u4e00\u3064\u3067\u306f\u306a\u304f\u3001\u907a\u4f1d\u7684\u306a\u80cc\u666f\u306b\u52a0\u3048\u3066\u3001\u598a\u5a20\u4e2d\u306e\u74b0\u5883\u3084\u6804\u990a\u72b6\u614b\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u56e0\u5b50\u304c\u8907\u96d1\u306b\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002\n  <\/p>\n  <p>\n    \u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u8449\u9178\u3084\u30d3\u30bf\u30df\u30f3D\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u306a\u3069\u3001\u65e5\u5e38\u751f\u6d3b\u306e\u4e2d\u3067\u8abf\u6574\u53ef\u80fd\u306a\u6804\u990a\u7d20\u304c\u3001ASD\u306e\u30ea\u30b9\u30af\u3092\u548c\u3089\u3052\u308b\u300c\u4e88\u9632\u7684\u306a\u56e0\u5b50\u300d\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u9ad8\u8102\u80aa\u98df\u3084\u6804\u990a\u306e\u504f\u308a\u306f\u3001ASD\u306b\u95a2\u9023\u3059\u308b\u7279\u6027\uff08\u793e\u4f1a\u6027\u306e\u56f0\u96e3\u3001\u611f\u899a\u306e\u654f\u611f\u3055\u306a\u3069\uff09\u3092\u5f37\u3081\u308b\u53ef\u80fd\u6027\u3082\u3042\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\n  <\/p>\n  <p>\n    \u672c\u8a18\u4e8b\u3067\u306f\u3001ASD\u306e\u75c7\u72b6\u3001\u8a3a\u65ad\u3001\u305d\u3057\u3066\u6700\u65b0\u306e\u6804\u990a\u7814\u7a76\u3068\u306e\u95a2\u308f\u308a\u306b\u3064\u3044\u3066\u3001\u79d1\u5b66\u7684\u6839\u62e0\u3092\u3082\u3068\u306b\u3084\u3055\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002\u8178\u3068\u8133\u306e\u3064\u306a\u304c\u308a\uff08\u8178\u2013\u8133\u8ef8\uff09\u3084\u3001\u907a\u4f1d\u3068\u6804\u990a\u306e\u76f8\u4e92\u4f5c\u7528\u3068\u3044\u3063\u305f\u91cd\u8981\u306a\u30c6\u30fc\u30de\u306b\u3082\u89e6\u308c\u306a\u304c\u3089\u3001\u3054\u5bb6\u65cf\u3084\u598a\u5a20\u3092\u8003\u3048\u308b\u65b9\u3005\u306e\u7406\u89e3\u3068\u9078\u629e\u3092\u652f\u3048\u308b\u60c5\u5831\u3092\u304a\u5c4a\u3051\u3057\u307e\u305f\u3089\u5e78\u3044\u3067\u3059\u3002\n  <\/p>\n<\/div>\n\n<\/p>\n  <\/p>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%A6%82%E8%A6%81%EF%BD%9COverview%EF%BC%88%E6%94%B9%E8%A8%82%E7%89%88%EF%BC%89\"><\/span>\u6982\u8981\uff5cOverview\uff08\u6539\u8a02\u7248\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-spectrum-disorder-genetics\/\">\u81ea\u9589\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u75c7<\/a>\uff08Autism Spectrum Disorder, ASD\uff09\u306f\u3001\u793e\u4f1a\u7684\u306a\u76f8\u4e92\u4f5c\u7528\u306b\u304a\u3051\u308b\u56f0\u96e3\u3055\u3084\u3001\u7279\u5b9a\u306e\u7269\u4e8b\u3078\u306e\u5f37\u3044\u95a2\u5fc3\u3001\u540c\u3058\u884c\u52d5\u3092\u7e70\u308a\u8fd4\u3059\u50be\u5411\u306a\u3069\u3001\u591a\u69d8\u306a\u795e\u7d4c\u767a\u9054\u306e\u7279\u5fb4\u3092\u542b\u3080\u8907\u96d1\u306a\u72b6\u614b\u3067\u3059\u3002ASD\u306e\u767a\u75c7\u3084\u305d\u306e\u91cd\u75c7\u5ea6\u306b\u306f\u3001\u907a\u4f1d\u7684\u306a\u80cc\u666f\u3060\u3051\u3067\u306a\u304f\u3001\u598a\u5a20\u4e2d\u3084\u51fa\u751f\u5f8c\u306e\u74b0\u5883\u8981\u56e0\u3092\u542b\u3081\u305f\u3055\u307e\u3056\u307e\u306a\u56e0\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u539f\u56e0\u3084\u7d4c\u904e\uff08\u75c5\u56e0\u30fb\u75c5\u614b\uff09\u306f\u3001\u5358\u4e00\u306e\u8981\u56e0\u3067\u306f\u8aac\u660e\u3067\u304d\u306a\u3044\u591a\u9762\u7684\u306a\u3082\u306e\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u3053\u3046\u3057\u305f\u74b0\u5883\u8981\u56e0\u306e\u4e2d\u3067\u3082\u3001\u3068\u304f\u306b\u598a\u5a20\u4e2d\u306e\u6bcd\u89aa\u306e\u98df\u4e8b\u5185\u5bb9\u3084\u3001\u51fa\u751f\u5f8c\u306e\u5b50\u3069\u3082\u306e\u98df\u751f\u6d3b\u304c\u3001\u795e\u7d4c\u767a\u9054\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u3064\u3044\u3066\u306e\u6ce8\u76ee\u304c\u9ad8\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u6bcd\u4f53\u304c\u6442\u53d6\u3059\u308b\u6804\u990a\u7d20\u306e\u7a2e\u985e\u3084\u91cf\u304c\u3001\u80ce\u5150\u306e\u8133\u306e\u69cb\u9020\u7684\u30fb\u6a5f\u80fd\u7684\u306a\u6210\u719f\u306b\u9577\u671f\u7684\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3001ASD\u306e\u30ea\u30b9\u30af\u3084\u75c7\u72b6\u306e\u5f37\u3055\u306b\u95a2\u9023\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u3001\u52d5\u7269\u30e2\u30c7\u30eb\u3084\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3001\u81e8\u5e8a\u8a66\u9a13\u306a\u3069\u3092\u901a\u3058\u3066\u6b21\u7b2c\u306b\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u80cc\u666f\u306e\u3082\u3068\u3001\u6804\u990a\u306f\u300c\u8abf\u6574\u53ef\u80fd\uff08modifiable\uff09\u300d\u306a\u74b0\u5883\u8981\u56e0\u306e\u3072\u3068\u3064\u3068\u3057\u3066\u3001ASD\u306e\u4e88\u9632\u3084\u7ba1\u7406\u306b\u304a\u3051\u308b\u9375\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u672c\u8a18\u4e8b\u3067\u306f\u3001\u52d5\u7269\u5b9f\u9a13\u3084\u30d2\u30c8\u3092\u5bfe\u8c61\u3068\u3057\u305f\u81e8\u5e8a\u7814\u7a76\u3001\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3001\u3055\u3089\u306b\u306f\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u3068\u3044\u3063\u305f\u591a\u69d8\u306a\u7814\u7a76\u624b\u6cd5\u306b\u57fa\u3065\u304d\u3001\u598a\u5a20\u4e2d\u306e\u6bcd\u4f53\u306e\u6804\u990a\u72b6\u614b\u304c\u80ce\u5150\u306e\u795e\u7d4c\u767a\u9054\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u3064\u3044\u3066\u306e\u6700\u65b0\u306e\u77e5\u898b\u3092\u7dcf\u5408\u7684\u306b\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u8449\u9178\u3084\u30d3\u30bf\u30df\u30f3D\u306a\u3069\u306e\u5fae\u91cf\u6804\u990a\u7d20\u3001\u8102\u8cea\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3044\u3063\u305f\u4e3b\u8981\u6804\u990a\u7d20\u306e\u5f79\u5272\u3001\u8178\u5185\u7d30\u83cc\u53e2\uff08gut microbiota\uff09\u3068\u8133\u306e\u767a\u9054\u3068\u306e\u95a2\u4fc2\u3001\u305d\u3057\u3066\u6804\u990a\u3068\u907a\u4f1d\u7684\u7d20\u56e0\u306e\u76f8\u4e92\u4f5c\u7528\uff08gene\u2013nutrient interactions\uff09\u306a\u3069\u304c\u53d6\u308a\u4e0a\u3052\u3089\u308c\u307e\u3059\u3002\u3055\u3089\u306b\u3001DNA\u30e1\u30c1\u30eb\u5316\u3068\u3044\u3063\u305f\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u4fee\u98fe\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3001\u795e\u7d4c\u514d\u75ab\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u3068\u3044\u3063\u305f\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u3082\u3001\u53ef\u80fd\u306a\u9650\u308a\u308f\u304b\u308a\u3084\u3059\u304f\u89e3\u8aac\u3057\u3066\u307e\u3044\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001\u3053\u3053\u3067\u3054\u7d39\u4ecb\u3059\u308b\u6804\u990a\u306b\u95a2\u3059\u308b\u77e5\u898b\u306f\u3001\u3042\u304f\u307e\u3067\u79d1\u5b66\u7684\u7814\u7a76\u306b\u57fa\u3065\u304f\u300c\u88dc\u5b8c\u7684\u300d\u306a\u8996\u70b9\u3067\u3042\u308a\u3001\u73fe\u5728\u78ba\u7acb\u3055\u308c\u3066\u3044\u308b\u6a19\u6e96\u7684\u306a\u8a3a\u65ad\u3084\u6cbb\u7642\u6cd5\u306b\u53d6\u3063\u3066\u4ee3\u308f\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u3053\u3068\u306b\u3054\u7559\u610f\u304f\u3060\u3055\u3044\u3002ASD\u3092\u542b\u3080\u795e\u7d4c\u767a\u9054\u75c7\u306f\u3001\u305d\u306e\u591a\u304f\u304c\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u7684\u8981\u56e0\u306e\u8907\u96d1\u306a\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u300c\u591a\u56e0\u5b50\u6027\u75be\u60a3\u300d\u3067\u3042\u308a\u3001\u6804\u990a\u3060\u3051\u3067\u3059\u3079\u3066\u3092\u4e88\u9632\u3057\u305f\u308a\u3001\u75c7\u72b6\u3092\u5b8c\u5168\u306b\u53d6\u308a\u9664\u3044\u305f\u308a\u3059\u308b\u3053\u3068\u306f\u73fe\u6642\u70b9\u3067\u306f\u56f0\u96e3\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u308c\u3067\u3082\u3001\u598a\u5a20\u671f\u3068\u3044\u3046\u91cd\u8981\u306a\u6642\u671f\u306b\u304a\u3051\u308b\u6804\u990a\u72b6\u614b\u304c\u3001\u767a\u9054\u4e2d\u306e\u80ce\u5150\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3046\u308b\u3068\u3044\u3046\u4e8b\u5b9f\u306f\u3001\u591a\u304f\u306e\u7814\u7a76\u3092\u901a\u3058\u3066\u652f\u6301\u3055\u308c\u3066\u304a\u308a\u3001\u3054\u5bb6\u65cf\u3084\u598a\u5a20\u3092\u8003\u3048\u308b\u65b9\u3005\u3001\u307e\u305f\u533b\u7642\u3084\u652f\u63f4\u306b\u95a2\u308f\u308b\u5c02\u9580\u8077\u306e\u65b9\u3005\u306b\u3068\u3063\u3066\u3001\u5c06\u6765\u306e\u5065\u5eb7\u3068\u767a\u9054\u3092\u8003\u3048\u308b\u3046\u3048\u3067\u306e\u3072\u3068\u3064\u306e\u91cd\u8981\u306a\u624b\u304c\u304b\u308a\u3068\u306a\u308a\u5f97\u307e\u3059\u3002\u672c\u8a18\u4e8b\u304c\u3001ASD\u306b\u95a2\u3059\u308b\u7406\u89e3\u3092\u6df1\u3081\u3001\u9069\u5207\u306a\u6e96\u5099\u3084\u9078\u629e\u3092\u652f\u3048\u308b\u4e00\u52a9\u3068\u306a\u308b\u3053\u3068\u3092\u9858\u3063\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%96%AB%E5%AD%A6%EF%BD%9CEpidemiology\"><\/span>\u75ab\u5b66\uff5cEpidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>ASD\u306f\u3001\u73fe\u5728\u3001\u4e16\u754c\u4e2d\u306e\u5b50\u3069\u3082\u306e\u304a\u3088\u305d1\u301c2\uff05\u306b\u307f\u3089\u308c\u308b\u3068\u3055\u308c\u3066\u304a\u308a\u3001\u6bd4\u8f03\u7684\u9ad8\u3044\u983b\u5ea6\u3067\u8a3a\u65ad\u3055\u308c\u308b\u795e\u7d4c\u767a\u9054\u75c7\u306e\u3072\u3068\u3064\u3067\u3059\u3002\u305f\u3060\u3057\u3001\u3053\u306e\u6709\u75c5\u7387\u306b\u306f\u5730\u57df\u5dee\u3084\u6642\u4ee3\u306b\u3088\u308b\u5909\u52d5\u304c\u3042\u308a\u3001\u305d\u306e\u6570\u5024\u306f\u4e00\u69d8\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u8a3a\u65ad\u57fa\u6e96\u306e\u9055\u3044\u3084\u3001\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\uff08\u767a\u9054\u691c\u67fb\u3084\u554f\u8a3a\uff09\u306e\u5b9f\u65bd\u72b6\u6cc1\u3001\u8abf\u67fb\u5bfe\u8c61\u3068\u306a\u308b\u96c6\u56e3\u306e\u7279\u6027\u3001\u3055\u3089\u306b\u306f\u533b\u7642\u5236\u5ea6\u3084\u793e\u4f1a\u7684\u306a\u7406\u89e3\u306e\u9032\u5c55\u5ea6\u306b\u3088\u3063\u3066\u3082\u3001\u8a3a\u65ad\u3055\u308c\u308b\u5272\u5408\u306b\u5dee\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/#anchor_sex\">\u6027\u5225<\/a>\u306b\u3088\u308b\u9055\u3044\u3082\u53e4\u304f\u304b\u3089\u6307\u6458\u3055\u308c\u3066\u304a\u308a\u3001ASD\u306f\u4e00\u822c\u7684\u306b\u7537\u5150\u306b\u591a\u304f\u307f\u3089\u308c\u308b\u50be\u5411\u304c\u3042\u308b\u3068\u3055\u308c\u3001\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u7537\u5973\u6bd4\u306f\u304a\u304a\u3088\u305d4\u5bfe1\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u5973\u5150\u306b\u304a\u3044\u3066\u306f\u8a3a\u65ad\u304c\u898b\u9003\u3055\u308c\u3084\u3059\u3044\uff08\u3044\u308f\u3086\u308b\u30a2\u30f3\u30c0\u30fc\u30c0\u30a4\u30a2\u30b0\u30ce\u30b7\u30b9\uff09\u50be\u5411\u304c\u3042\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u304a\u308a\u3001\u5b9f\u969b\u306e\u6027\u5dee\u306f\u3053\u308c\u307e\u3067\u8003\u3048\u3089\u308c\u3066\u3044\u305f\u3088\u308a\u3082\u5c0f\u3055\u3044\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059\u3002\u5973\u5150\u3067\u306f\u3001ASD\u306e\u75c7\u72b6\u304c\u793e\u4f1a\u7684\u306b\u300c\u76ee\u7acb\u3061\u306b\u304f\u3044\u300d\u5f62\u3067\u8868\u308c\u308b\u3053\u3068\u304c\u3042\u308b\u305f\u3081\u3001\u65e9\u671f\u306e\u6c17\u3065\u304d\u3084\u652f\u63f4\u306b\u3064\u306a\u304c\u308a\u306b\u304f\u3044\u3068\u3044\u3046\u8ab2\u984c\u3082\u6b8b\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>ASD\u306e\u306a\u308a\u3084\u3059\u3055\u3001\u3059\u306a\u308f\u3061\u907a\u4f1d\u7684\u306a\u5f71\u97ff\u306e\u5f37\u3055\u3092\u793a\u3059\u300c\u907a\u4f1d\u7387\uff08heritability\uff09\u300d\u306f\u3001\u904e\u53bb\u306e\u53cc\u751f\u5150\u7814\u7a76\u3084\u5bb6\u7cfb\u8abf\u67fb\u304b\u3089\u3001\u304a\u3088\u305d50\u301c80\uff05\u306e\u7bc4\u56f2\u306b\u3042\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001ASD\u306e\u767a\u75c7\u306b\u304a\u3044\u3066\u907a\u4f1d\u7684\u7d20\u56e0\u304c\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u304c\u3001\u305d\u308c\u3060\u3051\u3067\u306f\u767a\u75c7\u3092\u8aac\u660e\u3057\u304d\u308c\u306a\u3044\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u5b9f\u969b\u306b\u306f\u3001\u907a\u4f1d\u7684\u80cc\u666f\u3068\u4e26\u3093\u3067\u3001\u80ce\u5150\u671f\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u3055\u307e\u3056\u307e\u306a\u74b0\u5883\u8981\u56e0\u304c\u8907\u96d1\u306b\u91cd\u306a\u308a\u5408\u3046\u3053\u3068\u306b\u3088\u3063\u3066\u3001ASD\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u74b0\u5883\u7684\u306a\u8981\u56e0\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u306e\u306f\u3001\u305f\u3068\u3048\u3070\u598a\u5a20\u4e2d\u306e\u611f\u67d3\u75c7\u3078\u306e\u7f79\u60a3\u3001\u7cd6\u4ee3\u8b1d\u7570\u5e38\u3084\u80a5\u6e80\u3068\u3044\u3063\u305f\u4ee3\u8b1d\u6027\u306e\u75be\u60a3\u3001\u598a\u5a20\u671f\u306b\u304a\u3051\u308b\u5f37\u3044\u5fc3\u7406\u7684\u30b9\u30c8\u30ec\u30b9\u306a\u3069\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u8981\u56e0\u306f\u3001\u3044\u305a\u308c\u3082\u6bcd\u4f53\u306e\u4f53\u5185\u74b0\u5883\u3084\u514d\u75ab\u5fdc\u7b54\u3092\u901a\u3058\u3066\u3001\u80ce\u5150\u306e\u8133\u3084\u795e\u7d4c\u7cfb\u306e\u767a\u9054\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u3057\u3066\u8fd1\u5e74\u3001\u3053\u308c\u3089\u306e\u8981\u56e0\u306e\u4e2d\u3067\u3082\u3068\u304f\u306b\u95a2\u5fc3\u304c\u9ad8\u307e\u3063\u3066\u3044\u308b\u306e\u304c\u300c\u6bcd\u4f53\u306e\u6804\u990a\u72b6\u614b\u300d\u3067\u3059\u3002\u3068\u304f\u306b\u3001\u53d7\u80ce\u524d\u5f8c\u306e\u6642\u671f\uff08periconceptional 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class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%97%87%E7%8A%B6%EF%BD%9CSymptoms\"><\/span>\u75c7\u72b6\uff5cSymptoms<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading hidden-heading\"><\/h3>\n\n\n\n<p>ASD\u306f\u3001\u5e83\u7bc4\u56f2\u306b\u308f\u305f\u308b\u795e\u7d4c\u767a\u9054\u306e\u7279\u5fb4\u3092\u542b\u3080\u72b6\u614b\u3067\u3059\u304c\u3001\u305d\u306e\u8a3a\u65ad\u306b\u304a\u3044\u3066\u4e2d\u5fc3\u7684\u3068\u3055\u308c\u308b\u306e\u306f\u3001\u4e3b\u306b\u6b21\u306e\u4e8c\u3064\u306e\u9818\u57df\u306b\u304a\u3051\u308b\u7279\u5fb4\u7684\u306a\u884c\u52d5\u3084\u50be\u5411\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305a\u4e00\u3064\u76ee\u306f\u3001\u300c\u793e\u4f1a\u7684\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u3068\u5bfe\u4eba\u95a2\u4fc2\u306e\u56f0\u96e3\u3055\u300d\u3067\u3059\u3002\u3053\u308c\u306f\u3001\u4ed6\u8005\u3068\u306e\u3084\u308a\u3068\u308a\u306b\u304a\u3044\u3066\u3001\u81ea\u7136\u306a\u53cd\u5fdc\u3084\u95a2\u4fc2\u69cb\u7bc9\u304c\u96e3\u3057\u3044\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u547c\u3073\u304b\u3051\u3078\u306e\u53cd\u5fdc\u304c\u4e4f\u3057\u3044\u3001\u76ee\u3092\u5408\u308f\u305b\u308b\u983b\u5ea6\u304c\u5c11\u306a\u3044\u3001\u8eab\u3076\u308a\u3084\u8868\u60c5\u3068\u3044\u3063\u305f\u975e\u8a00\u8a9e\u7684\u306a\u30b5\u30a4\u30f3\u3092\u4f7f\u3046\u3053\u3068\u304c\u82e6\u624b\u3001\u4f1a\u8a71\u306e\u3084\u308a\u3068\u308a\u304c\u4e00\u65b9\u901a\u884c\u306b\u306a\u308a\u304c\u3061\u3067\u3042\u308b\u3001\u3068\u3044\u3063\u305f\u7279\u5fb4\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u540c\u5e74\u4ee3\u306e\u5b50\u3069\u3082\u305f\u3061\u3068\u306e\u9593\u3067\u53cb\u4eba\u95a2\u4fc2\u3092\u7bc9\u3044\u305f\u308a\u3001\u96c6\u56e3\u306e\u4e2d\u3067\u306e\u6697\u9ed9\u306e\u30eb\u30fc\u30eb\u3092\u7406\u89e3\u3057\u3066\u884c\u52d5\u3059\u308b\u3053\u3068\u304c\u96e3\u3057\u3044\u3068\u611f\u3058\u308b\u5834\u9762\u3082\u5c11\u306a\u304f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u4e8c\u3064\u76ee\u306f\u3001\u300c\u9650\u5b9a\u3055\u308c\u305f\u3001\u53cd\u5fa9\u7684\u306a\u884c\u52d5\u30fb\u8208\u5473\u30fb\u6d3b\u52d5\u306e\u50be\u5411\u300d\u3067\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u540c\u3058\u52d5\u304d\u3092\u7e70\u308a\u8fd4\u3059\u3001\u7279\u5b9a\u306e\u7269\u4e8b\u306b\u5f37\u304f\u3053\u3060\u308f\u308b\u3001\u65e5\u5e38\u306e\u6c7a\u307e\u3063\u305f\u6d41\u308c\u3084\u74b0\u5883\u306e\u5909\u5316\u306b\u5bfe\u3057\u3066\u5f37\u3044\u4e0d\u5b89\u3084\u62b5\u6297\u3092\u793a\u3059\u3068\u3044\u3063\u305f\u884c\u52d5\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u97f3\u3084\u5149\u3001\u306b\u304a\u3044\u3001\u89e6\u611f\u3068\u3044\u3063\u305f\u611f\u899a\u523a\u6fc0\u306b\u5bfe\u3057\u3066\u3001\u6975\u7aef\u306b\u654f\u611f\u3067\u3042\u3063\u305f\u308a\u3001\u9006\u306b\u920d\u611f\u3067\u3042\u3063\u305f\u308a\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7279\u5fb4\u306f\u3001\u4e00\u4eba\u3072\u3068\u308a\u306b\u3088\u3063\u3066\u8868\u308c\u65b9\u3084\u7a0b\u5ea6\u304c\u7570\u306a\u308a\u307e\u3059\u304c\u3001ASD\u306e\u8a3a\u65ad\u306b\u304a\u3051\u308b\u6838\u3068\u306a\u308b\u8981\u7d20\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u3046\u3057\u305f\u4e3b\u8981\u306a\u7279\u5fb4\u306b\u52a0\u3048\u3066\u3001ASD\u306e\u3042\u308b\u304a\u5b50\u3055\u3093\u306e\u4e2d\u306b\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u968f\u4f34\u75c7\u72b6\uff08comorbid symptoms\uff09\u3092\u793a\u3059\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u75c7\u72b6\u306f\u3001\u795e\u7d4c\u767a\u9054\u306e\u7279\u6027\u3060\u3051\u3067\u306a\u304f\u3001\u98df\u4e8b\u5185\u5bb9\u3084\u6804\u990a\u72b6\u614b\u3001\u6d88\u5316\u6a5f\u80fd\u3068\u3044\u3063\u305f\u8eab\u4f53\u7684\u306a\u5074\u9762\u3068\u3082\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u6442\u98df\u306e\u56f0\u96e3\uff08Feeding Difficulties\uff09<\/strong><\/h4>\n\n\n\n<p>\u5473\u3084\u98df\u611f\u3001\u6e29\u5ea6\u3001\u898b\u305f\u76ee\u306a\u3069\u306b\u5bfe\u3057\u3066\u5f37\u3044\u3053\u3060\u308f\u308a\u3092\u6301\u3064\u3053\u3068\u304c\u3042\u308a\u3001\u300c\u597d\u304d\u5acc\u3044\u300d\u3084\u300c\u9078\u308a\u597d\u307f\u300d\u304c\u6975\u7aef\u306a\u5f62\u3067\u73fe\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u7279\u5b9a\u306e\u98df\u3079\u7269\u3057\u304b\u53e3\u306b\u3057\u306a\u3044\u3001\u98df\u4e8b\u306e\u7a2e\u985e\u304c\u8457\u3057\u304f\u9650\u3089\u308c\u308b\u3068\u3044\u3063\u305f\u72b6\u6cc1\u306b\u306a\u308a\u3001\u6804\u990a\u306e\u504f\u308a\u304c\u751f\u3058\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u65e5\u3005\u306e\u98df\u4e8b\u306e\u4e2d\u3067\u3054\u5bb6\u65cf\u304c\u6700\u3082\u60a9\u3080\u8ab2\u984c\u306e\u3072\u3068\u3064\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u6d88\u5316\u5668\u75c7\u72b6\uff08Gastrointestinal Symptoms\uff09<\/strong><\/h4>\n\n\n\n<p>\u4fbf\u79d8\u3001\u4e0b\u75e2\u3001\u8179\u90e8\u306e\u5f35\u308a\u3001\u75db\u307f\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u6d88\u5316\u5668\u306e\u4e0d\u8abf\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002ASD\u306e\u304a\u5b50\u3055\u3093\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u75c7\u72b6\u304c\u6162\u6027\u7684\u306b\u307f\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u3001\u8178\u5185\u7d30\u83cc\u53e2\u306e\u4e71\u308c\uff08dysbiosis\uff09\u3084\u3001\u98df\u7269\u7e4a\u7dad\u306e\u6442\u53d6\u4e0d\u8db3\u3001\u904e\u654f\u6027\u8178\u75c7\u5019\u7fa4\uff08IBS\uff09\u306b\u4f3c\u305f\u53cd\u5fdc\u306a\u3069\u3001\u8907\u6570\u306e\u8981\u56e0\u304c\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u6d88\u5316\u306e\u4e0d\u8abf\u304c\u884c\u52d5\u9762\u306b\u3082\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u8fd1\u5e74\u3001\u8178\u3068\u8133\u306e\u95a2\u4fc2\uff08\u8178\u2013\u8133\u8ef8\uff09\u306e\u91cd\u8981\u6027\u304c\u518d\u8a8d\u8b58\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u5fae\u91cf\u6804\u990a\u7d20\u306e\u4e0d\u8db3\uff08Micronutrient Deficiencies\uff09<\/strong><\/h4>\n\n\n\n<p>\u504f\u3063\u305f\u98df\u4e8b\u3084\u6442\u98df\u969c\u5bb3\u306e\u5f71\u97ff\u306b\u3088\u308a\u3001\u9244\u5206\u3001\u30d3\u30bf\u30df\u30f3D\u3001\u8449\u9178\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u306a\u3069\u306e\u91cd\u8981\u306a\u6804\u990a\u7d20\u304c\u4e0d\u8db3\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u305f\u3068\u3048\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u6442\u3063\u3066\u3044\u3066\u3082\u3001\u8178\u5185\u74b0\u5883\u3084\u4ee3\u8b1d\u306e\u72b6\u614b\u306b\u3088\u3063\u3066\u306f\u5438\u53ce\u52b9\u7387\u304c\u4f4e\u304f\u3001\u4f53\u5185\u3067\u5341\u5206\u306b\u6d3b\u7528\u3055\u308c\u3066\u3044\u306a\u3044\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u6804\u990a\u306e\u4e0d\u8db3\u306f\u3001\u96c6\u4e2d\u529b\u3084\u60c5\u7dd2\u306e\u5b89\u5b9a\u3001\u514d\u75ab\u6a5f\u80fd\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u614e\u91cd\u306a\u5bfe\u5fdc\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u8a8d\u77e5\u3084\u884c\u52d5\u9762\u306e\u75c7\u72b6\uff08Cognitive and Behavioral Manifestations\uff09<\/strong><\/h4>\n\n\n\n<p>ASD\u306e\u304a\u5b50\u3055\u3093\u306e\u4e2d\u306b\u306f\u3001\u904e\u6d3b\u52d5\uff08hyperactivity\uff09\u3001\u6ce8\u610f\u306e\u6301\u7d9a\u306e\u96e3\u3057\u3055\u3001\u4e0d\u7720\u3084\u4e2d\u9014\u899a\u9192\u3068\u3044\u3063\u305f\u7761\u7720\u969c\u5bb3\u3001\u8a00\u8a9e\u767a\u9054\u306e\u9045\u308c\u306a\u3069\u3092\u793a\u3059\u65b9\u3082\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u75c7\u72b6\u306f\u3001ASD\u305d\u306e\u3082\u306e\u306e\u795e\u7d4c\u767a\u9054\u306e\u7279\u6027\u306b\u3088\u308b\u90e8\u5206\u306b\u52a0\u3048\u3066\u3001\u4f53\u5185\u306e\u708e\u75c7\u72b6\u614b\u3084\u6804\u990a\u30d0\u30e9\u30f3\u30b9\u306e\u4e71\u308c\u3068\u3044\u3063\u305f\u751f\u7406\u7684\u306a\u8981\u56e0\u3068\u3082\u95a2\u9023\u304c\u3042\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%A4%9C%E6%9F%BB%E3%83%BB%E8%A8%BA%E6%96%AD%EF%BD%9CTesting_Diagnosis\"><\/span><strong>\u691c\u67fb\u30fb\u8a3a\u65ad\uff5cTesting &amp; Diagnosis<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"ASD%E3%81%AE%E8%A8%BA%E6%96%AD%E3%81%AB%E3%81%A4%E3%81%84%E3%81%A6\"><\/span><strong>ASD\u306e\u8a3a\u65ad\u306b\u3064\u3044\u3066<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>ASD\u306e\u8a3a\u65ad\u306f\u3001\u7279\u5b9a\u306e\u691c\u67fb\u3060\u3051\u3067\u78ba\u5b9a\u3059\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u5c02\u9580\u7684\u306a\u81e8\u5e8a\u8a55\u4fa1\uff08clinical evaluation\uff09\u306b\u3088\u3063\u3066\u884c\u308f\u308c\u307e\u3059\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u56fd\u969b\u7684\u306b\u8a8d\u3081\u3089\u308c\u305f\u8a55\u4fa1\u30c4\u30fc\u30eb\u304c\u4f7f\u308f\u308c\u308b\u3053\u3068\u304c\u4e00\u822c\u7684\u3067\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ADOS\uff08Autism Diagnostic Observation Schedule\uff1a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-spectrum-disorder-genetics\/\">\u81ea\u9589\u75c7<\/a>\u8a3a\u65ad\u89b3\u5bdf\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\uff09<\/strong><strong><br><\/strong>\u5c02\u9580\u5bb6\u304c\u5b9f\u969b\u306e\u3084\u308a\u3068\u308a\u3092\u901a\u3058\u3066\u3001\u793e\u4f1a\u6027\u3084\u884c\u52d5\u306e\u7279\u5fb4\u3092\u89b3\u5bdf\u3059\u308b\u65b9\u6cd5\u3067\u3059\u3002<br><\/li>\n\n\n\n<li><strong>ADI-R\uff08Autism Diagnostic Interview-Revised\uff1a\u6539\u8a02<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-spectrum-disorder-genetics\/\">\u81ea\u9589\u75c7<\/a>\u8a3a\u65ad\u9762\u63a5\uff09<\/strong><strong><br><\/strong>\u4fdd\u8b77\u8005\u306e\u65b9\u306b\u5bfe\u3059\u308b\u8a73\u7d30\u306a\u805e\u304d\u53d6\u308a\u8abf\u67fb\u3092\u901a\u3058\u3066\u3001\u884c\u52d5\u306e\u7279\u5fb4\u3084\u767a\u9054\u306e\u7d4c\u904e\u3092\u8a55\u4fa1\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:24px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u307e\u305f\u3001\u5927\u898f\u6a21\u306a\u75ab\u5b66\u7814\u7a76\uff08\u305f\u3068\u3048\u3070\u30a2\u30e1\u30ea\u30ab\u306e\u300cNurses\u2019 Health Study II\u300d\u306a\u3069\uff09\u3067\u306f\u3001\u4fdd\u8b77\u8005\u306b\u3088\u308b\u7533\u544a\uff08\u89aa\u5831\u544a\uff1aparental report\uff09\u3092\u3082\u3068\u306bASD\u306e\u8a3a\u65ad\u304c\u306a\u3055\u308c\u305f\u30b1\u30fc\u30b9\u3082\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u3088\u3046\u306a\u7814\u7a76\u3067\u306f\u3001\u4e00\u90e8\u306e\u53c2\u52a0\u8005\u306b\u3064\u3044\u3066\u306f\u5b9f\u969b\u306e\u533b\u7642\u8a18\u9332\u3084\u81e8\u5e8a\u8a55\u4fa1\u3092\u901a\u3058\u3066\u3001\u8a3a\u65ad\u306e\u6b63\u78ba\u6027\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"ASD%E9%96%A2%E9%80%A3%E7%89%B9%E6%80%A7%E3%81%AE%E8%A9%95%E4%BE%A1\"><\/span><strong>ASD\u95a2\u9023\u7279\u6027\u306e\u8a55\u4fa1<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>ASD\u306e\u8a3a\u65ad\u3060\u3051\u3067\u306a\u304f\u3001ASD\u306b\u95a2\u9023\u3059\u308b\u7279\u6027\u3084\u50be\u5411\u3092\u3088\u308a\u5e83\u3044\u8996\u70b9\u304b\u3089\u3068\u3089\u3048\u308b\u305f\u3081\u306b\u3001\u591a\u304f\u306e\u7814\u7a76\u3067\u4f7f\u308f\u308c\u3066\u3044\u308b\u5c3a\u5ea6\u304c\u300cSRS\uff08Social Responsiveness Scale\uff1a\u793e\u4f1a\u7684\u5fdc\u7b54\u6027\u5c3a\u5ea6\uff09\u300d\u3067\u3059\u3002<\/p>\n\n\n\n<p>SRS\u306f\u3001\u793e\u4f1a\u7684\u306a\u884c\u52d5\u3084\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u306e\u7279\u5fb4\u3092\u5b9a\u91cf\u7684\u306b\u8a55\u4fa1\u3067\u304d\u308b\u8cea\u554f\u7968\u3067\u3001\u5e74\u9f62\u306b\u5fdc\u3058\u305f\u30d0\u30fc\u30b8\u30e7\u30f3\uff08\u5e7c\u5150\u7528\uff0f\u5b66\u7ae5\u7528\u306a\u3069\uff09\u304c\u3042\u308a\u3001\u30b9\u30b3\u30a2\u306e\u7b97\u51fa\u65b9\u6cd5\u306f\u7d71\u4e00\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30b9\u30b3\u30a2\u304c\u9ad8\u3044\u307b\u3069\u3001ASD\u306b\u95a2\u9023\u3059\u308b\u884c\u52d5\u50be\u5411\u304c\u5f37\u3044\u3053\u3068\u3092\u793a\u3057\u307e\u3059\u304c\u3001\u8a3a\u65ad\u57fa\u6e96\u3092\u6e80\u305f\u3055\u306a\u3044\u300c\u30b0\u30ec\u30fc\u30be\u30fc\u30f3\u300d\u306e\u50be\u5411\u3082\u542b\u3081\u3066\u8a55\u4fa1\u3067\u304d\u308b\u306e\u304c\u7279\u9577\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306a\u5b9a\u91cf\u8a55\u4fa1\u306f\u3001\u598a\u5a20\u4e2d\u306e\u6804\u990a\u3084\u74b0\u5883\u8981\u56e0\u3068ASD\u50be\u5411\u306e\u95a2\u4fc2\u3092\u691c\u8a0e\u3059\u308b\u969b\u306b\u3082\u91cd\u8981\u306a\u6307\u6a19\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%A0%84%E9%A4%8A%E6%91%82%E5%8F%96%E3%81%AE%E8%A9%95%E4%BE%A1%E6%96%B9%E6%B3%95\"><\/span><strong>\u6804\u990a\u6442\u53d6\u306e\u8a55\u4fa1\u65b9\u6cd5<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u598a\u5a20\u4e2d\u3084\u4e73\u5e7c\u5150\u671f\u306e\u6804\u990a\u6442\u53d6\u3092\u6b63\u78ba\u306b\u8a55\u4fa1\u3059\u308b\u3053\u3068\u306f\u3001\u7814\u7a76\u3084\u81e8\u5e8a\u306b\u304a\u3044\u3066\u975e\u5e38\u306b\u91cd\u8981\u3067\u3059\u304c\u3001\u65b9\u6cd5\u306b\u3088\u3063\u3066\u5f97\u3089\u308c\u308b\u60c5\u5831\u306b\u306f\u9055\u3044\u304c\u3042\u308a\u307e\u3059\u3002\u4ee5\u4e0b\u306f\u3001\u7814\u7a76\u3067\u3088\u304f\u4f7f\u308f\u308c\u308b\u4e3b\u306a\u8a55\u4fa1\u624b\u6cd5\u3067\u3059\uff1a<\/p>\n\n\n\n<p><strong>\u98df\u4e8b\u983b\u5ea6\u8cea\u554f\u7968\uff08FFQs\uff1aFood Frequency Questionnaires\uff09<\/strong><strong><br><\/strong>\u7279\u5b9a\u306e\u98df\u54c1\u3092\u3069\u306e\u304f\u3089\u3044\u306e\u983b\u5ea6\u3067\u6442\u3063\u3066\u3044\u308b\u304b\u3092\u628a\u63e1\u3059\u308b\u65b9\u6cd5\u3067\u3001\u5927\u898f\u6a21\u306a\u30b3\u30db\u30fc\u30c8\u7814\u7a76\uff08\u4f8b\uff1aNHSII\u3001ECHO\uff09\u306a\u3069\u3067\u3088\u304f\u4f7f\u308f\u308c\u3066\u3044\u307e\u3059\u3002<br><\/p>\n\n\n\n<p><strong>24\u6642\u9593\u98df\u4e8b\u60f3\u8d77\u6cd5\u30fb\u98df\u4e8b\u6b74\u8abf\u67fb\u7968\uff08Diet History Questionnaire, DHQ\uff09<\/strong><strong><br><\/strong>\u904e\u53bb1\u65e5\u30841\u9031\u9593\u306e\u98df\u4e8b\u5185\u5bb9\u3092\u8a73\u7d30\u306b\u805e\u304d\u53d6\u308b\u65b9\u6cd5\u3067\u3059\u3002<br><\/p>\n\n\n\n<p><strong>\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\uff08biomarkers\uff09<\/strong><strong><br><\/strong>\u8840\u6db2\u4e2d\u306e\u8449\u9178\u3084\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u306a\u3069\u3001\u4f53\u5185\u306b\u3069\u308c\u304f\u3089\u3044\u6804\u990a\u7d20\u304c\u5b58\u5728\u3057\u3066\u3044\u308b\u304b\u3092\u6e2c\u5b9a\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u3088\u308a\u5ba2\u89b3\u7684\u306a\u30c7\u30fc\u30bf\u3067\u3059\u304c\u3001\u80ce\u5150\u306e\u767a\u9054\u306b\u3068\u3063\u3066\u91cd\u8981\u306a\u6642\u671f\u3068\u6e2c\u5b9a\u6642\u671f\u304c\u4e00\u81f4\u3057\u306a\u3044\u5834\u5408\u306f\u3001\u60c5\u5831\u304c\u9650\u5b9a\u7684\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<br><\/p>\n\n\n\n<p>\u307e\u305f\u3001\u98df\u4e8b\u5168\u4f53\u306e\u8cea\u3084\u708e\u75c7\u3068\u306e\u95a2\u9023\u3092\u898b\u308b\u305f\u3081\u306b\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u98df\u4e8b\u8a55\u4fa1\u30b9\u30b3\u30a2\u304c\u7528\u3044\u3089\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AHEI-2010\uff08Alternative Healthy Eating Index\uff09<\/strong>\uff1a\u5065\u5eb7\u7684\u306a\u98df\u4e8b\u306e\u6307\u6a19<\/li>\n\n\n\n<li><strong>EDIP\uff08Empirical Dietary Inflammatory Pattern\uff09<\/strong>\uff1a\u98df\u4e8b\u306e\u708e\u75c7\u6027\u50be\u5411\u3092\u8a55\u4fa1<\/li>\n\n\n\n<li><strong>HEI-2015\uff08Healthy Eating Index\uff09<\/strong>\uff1a\u6804\u990a\u30d0\u30e9\u30f3\u30b9\u5168\u4f53\u3092\u8a55\u4fa1\u3059\u308b\u30b9\u30b3\u30a2<\/li>\n<\/ul>\n\n\n\n<div style=\"height:24px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u308c\u3089\u306f\u3001\u5358\u4e00\u306e\u6804\u990a\u7d20\u3067\u306f\u306a\u304f\u3001\u98df\u4e8b\u5168\u4f53\u306e\u30d1\u30bf\u30fc\u30f3\u304cASD\u306e\u50be\u5411\u3084\u30ea\u30b9\u30af\u306b\u3069\u3046\u5f71\u97ff\u3059\u308b\u304b\u3092\u63a2\u308b\u969b\u306b\u7528\u3044\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%97%85%E5%9B%A0%E3%81%A8%E3%81%9D%E3%81%AE%E7%AE%A1%E7%90%86%EF%BD%9CEtiology_Management\"><\/span><strong>\u75c5\u56e0\u3068\u305d\u306e\u7ba1\u7406\uff5cEtiology &amp; Management<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>ASD\u306f\u3001\u8ab0\u304b\u306e\u80b2\u3066\u65b9\u3084\u4f55\u304b\u3072\u3068\u3064\u306e\u884c\u52d5\u304c\u539f\u56e0\u3067\u8d77\u3053\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u73fe\u5728\u308f\u304b\u3063\u3066\u3044\u308b\u306e\u306f\u3001\u3053\u306e\u72b6\u614b\u304c\u3001\u3082\u3068\u3082\u3068\u306e\u907a\u4f1d\u7684\u306a\u4f53\u8cea\u3068\u3001\u598a\u5a20\u4e2d\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u767a\u9054\u306e\u65e9\u3044\u6bb5\u968e\u306e\u74b0\u5883\u7684\u306a\u5f71\u97ff\u3068\u304c\u3001\u3044\u304f\u3064\u3082\u8907\u96d1\u306b\u91cd\u306a\u308a\u5408\u3063\u3066\u751f\u3058\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u306e\u4e2d\u3067\u3082\u8fd1\u5e74\u3068\u304f\u306b\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u306e\u304c\u3001\u300c\u6804\u990a\uff08nutrition\uff09\u300d\u306e\u5f71\u97ff\u3067\u3059\u3002\u598a\u5a20\u4e2d\u306e\u6bcd\u4f53\u306e\u6804\u990a\u72b6\u614b\u304c\u3001\u80ce\u5150\u306e\u8133\u3084\u795e\u7d4c\u7cfb\u306e\u767a\u9054\u3001\u514d\u75ab\u306e\u8abf\u6574\u6a5f\u80fd\uff08neuroimmune regulation\uff09\u3001\u3055\u3089\u306b\u306f\u8133\u5185\u306e\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\uff08neurotransmitters\uff09\u306e\u30d0\u30e9\u30f3\u30b9\u306b\u5927\u304d\u304f\u95a2\u308f\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3001\u3055\u307e\u3056\u307e\u306a\u7814\u7a76\u304b\u3089\u5831\u544a\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u3046\u3057\u305f\u80cc\u666f\u304b\u3089\u3001\u300c\u6804\u990a\u300d\u306f\u3001ASD\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u8981\u56e0\u3067\u3042\u308b\u3068\u540c\u6642\u306b\u3001\u3082\u3057\u304b\u3057\u305f\u3089\u75c7\u72b6\u3092\u3084\u308f\u3089\u3052\u305f\u308a\u3001\u767a\u75c7\u305d\u306e\u3082\u306e\u3092\u4e88\u9632\u3057\u305f\u308a\u3059\u308b\u300c\u7ba1\u7406\uff08management\uff09\u300d\u306e\u9375\u306b\u306a\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u8996\u70b9\u304c\u5e83\u304c\u3063\u3066\u3044\u307e\u3059\u3002\u3082\u3061\u308d\u3093\u3001\u6804\u990a\u304cASD\u306e\u6a19\u6e96\u7684\u306a\u6cbb\u7642\u6cd5\uff08standard treatment\uff09\u3068\u3057\u3066\u78ba\u7acb\u3055\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u5bb6\u65cf\u306e\u7acb\u5834\u304b\u3089\u3067\u304d\u308b\u3053\u3068\u3068\u3057\u3066\u3001\u300c\u88dc\u52a9\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\uff08complementary approach\uff09\u300d\u3068\u3057\u3066\u306e\u6804\u990a\u6226\u7565\u306b\u3001\u4e16\u754c\u4e2d\u3067\u95a2\u5fc3\u304c\u96c6\u307e\u3063\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u7ae0\u3067\u306f\u3001\u73fe\u5728\u306e\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u3066\u3044\u308b\u77e5\u898b\u3092\u3082\u3068\u306b\u3001\u598a\u5a20\u671f\u306e\u6804\u990a\u3068ASD\u3068\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u3054\u7d39\u4ecb\u3057\u3066\u3044\u304d\u307e\u3059\u3002\u5c02\u9580\u7684\u306a\u5185\u5bb9\u3082\u542b\u307e\u308c\u307e\u3059\u304c\u3001\u3072\u3068\u3064\u3072\u3068\u3064\u4e01\u5be7\u306b\u89e3\u8aac\u3057\u307e\u3059\u306e\u3067\u3001\u3069\u3046\u304b\u5b89\u5fc3\u3057\u3066\u8aad\u307f\u9032\u3081\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%91%89%E9%85%B8%EF%BC%88Folic_Acid_Folate%EF%BC%89%E3%81%A8%E5%A6%8A%E5%A8%A0%E6%BA%96%E5%82%99%EF%BC%9A%E6%9C%AA%E6%9D%A5%E3%81%AE%E8%84%B3%E3%81%AE%E3%81%9F%E3%82%81%E3%81%AB\"><\/span><strong>\u8449\u9178\uff08Folic Acid \/ Folate\uff09\u3068\u598a\u5a20\u6e96\u5099\uff1a\u672a\u6765\u306e\u8133\u306e\u305f\u3081\u306b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u8449\u9178\uff08folic acid \/ folate\uff09\u306f\u3001\u30d3\u30bf\u30df\u30f3B\u7fa4\uff08B-vitamin complex\uff09\u306e\u4e00\u7a2e\u3067\u3001\u598a\u5a20\u521d\u671f\u306e\u8d64\u3061\u3083\u3093\u306e\u795e\u7d4c\u7ba1\uff08neural tube\uff1a\u8133\u3084\u810a\u9ac4\u306e\u5143\u3068\u306a\u308b\u69cb\u9020\uff09\u304c\u6b63\u3057\u304f\u5f62\u6210\u3055\u308c\u308b\u305f\u3081\u306b\u4e0d\u53ef\u6b20\u306a\u6804\u990a\u7d20\u3067\u3059\u3002\u3053\u306e\u8449\u9178\u304c\u3001ASD\u306e\u30ea\u30b9\u30af\u306b\u3082\u95a2\u308f\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u3001\u591a\u304f\u306e\u75ab\u5b66\u7814\u7a76\uff08epidemiological studies\uff09\u304b\u3089\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305f\u3068\u3048\u3070\u3001\u598a\u5a20\u306e\u524d\u5f8c\u3084\u598a\u5a20\u521d\u671f\u306b\u8449\u9178\u3092\u6442\u53d6\u3057\u3066\u3044\u305f\u304a\u6bcd\u3055\u3093\u304b\u3089\u751f\u307e\u308c\u305f\u5b50\u3069\u3082\u3067\u306f\u3001ASD\u3092\u8a3a\u65ad\u3055\u308c\u308b\u78ba\u7387\u304c30\u301c60\uff05\u4f4e\u304b\u3063\u305f\u3068\u3059\u308b\u30c7\u30fc\u30bf\u304c\u3042\u308a\u307e\u3059\u3002\u3082\u3061\u308d\u3093\u3001\u3053\u308c\u306f\u8449\u9178\u3060\u3051\u3067\u3059\u3079\u3066\u3092\u9632\u3052\u308b\u3068\u3044\u3046\u610f\u5473\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305f\u3060\u3001\u300c\u8d64\u3061\u3083\u3093\u306e\u8133\u304c\u5f62\u3065\u304f\u3089\u308c\u308b\u5927\u5207\u306a\u6642\u671f\u306b\u3001\u5fc5\u8981\u306a\u6804\u990a\u3092\u3057\u3063\u304b\u308a\u5c4a\u3051\u308b\u3053\u3068\u300d\u304c\u3001\u305d\u306e\u5f8c\u306e\u795e\u7d4c\u767a\u9054\u306b\u826f\u3044\u5f71\u97ff\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u3001\u5927\u304d\u306a\u30d2\u30f3\u30c8\u3067\u3082\u3042\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001\u6ce8\u610f\u3057\u3066\u304a\u304d\u305f\u3044\u306e\u306f\u3001\u300c\u591a\u3051\u308c\u3070\u591a\u3044\u307b\u3069\u3088\u3044\u300d\u3068\u3044\u3046\u5358\u7d14\u306a\u8a71\u3067\u306f\u306a\u3044\u3053\u3068\u3067\u3059\u3002\u8840\u6db2\u4e2d\u306e\u8449\u9178\u6fc3\u5ea6\uff08blood folate concentration\uff09\u3092\u6307\u6a19\u3068\u3057\u305f\u7814\u7a76\u306e\u4e2d\u306b\u306f\u3001\u4e00\u5b9a\u306e\u6fc3\u5ea6\u3092\u8d85\u3048\u3066\u9ad8\u3059\u304e\u308b\uff08\u5177\u4f53\u7684\u306b\u306f60\u30ca\u30ce\u30e2\u30eb\uff0f\u30ea\u30c3\u30c8\u30eb [nmol\/L] \u4ee5\u4e0a\uff09\u5834\u5408\u306b\u3001\u304b\u3048\u3063\u3066ASD\u306e\u30ea\u30b9\u30af\u304c\u4e0a\u6607\u3059\u308b\u3068\u3044\u3046\u300cU\u5b57\u578b\uff08U-shaped relationship\uff09\u300d\u306e\u7d50\u679c\u3092\u793a\u3057\u305f\u3082\u306e\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001MTHFR\u907a\u4f1d\u5b50\uff08methylenetetrahydrofolate reductase gene\uff09\u3068\u3044\u3046\u9175\u7d20\u3092\u3064\u304f\u308b\u907a\u4f1d\u5b50\u306b\u7279\u5b9a\u306e\u591a\u578b\uff08polymorphism\uff1a\u907a\u4f1d\u7684\u306a\u500b\u4eba\u5dee\uff09\u3092\u6301\u3063\u3066\u3044\u308b\u4eba\u306f\u3001\u8449\u9178\u306e\u4ee3\u8b1d\uff08folate metabolism\uff09\u3084DNA\u306e\u30e1\u30c1\u30eb\u5316\uff08DNA methylation\uff09\u3068\u3044\u3063\u305f\u91cd\u8981\u306a\u751f\u4f53\u53cd\u5fdc\u306b\u5f71\u97ff\u304c\u51fa\u308b\u3053\u3068\u304c\u3042\u308a\u3001\u305d\u3046\u3057\u305f\u4f53\u8cea\u3092\u6301\u3064\u4eba\u3067\u306f\u8449\u9178\u306e\u6442\u53d6\u304c\u7279\u306b\u91cd\u8981\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u65e5\u672c\u3092\u542b\u3080\u591a\u304f\u306e\u56fd\u3067\u306f\u3001\u598a\u5a20\u3092\u8003\u3048\u3066\u3044\u308b\u5973\u6027\u306b\u5bfe\u3057\u3066\u30011\u65e5400\u301c800\u30de\u30a4\u30af\u30ed\u30b0\u30e9\u30e0\uff08micrograms\uff09\u306e\u8449\u9178\u3092\u598a\u5a20\u524d\u304b\u3089\u6442\u308b\u3053\u3068\u304c\u52e7\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u91cf\u306f\u3001\u4e00\u822c\u7684\u306a\u598a\u5a20\u7528\u30d3\u30bf\u30df\u30f3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\uff08prenatal vitamins\uff09\u3067\u30ab\u30d0\u30fc\u3067\u304d\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u8449\u9178\u306b\u52a0\u3048\u3066\u3001\u9244\u5206\uff08iron\uff09\u3084\u30d3\u30bf\u30df\u30f3D\uff08vitamin D\uff09\u306a\u3069\u3092\u542b\u3093\u3060\u30de\u30eb\u30c1\u30d3\u30bf\u30df\u30f3\uff08multivitamins\uff09\u3092\u5b9a\u671f\u7684\u306b\u6442\u53d6\u3057\u3066\u3044\u305f\u6bcd\u89aa\u3067\u306f\u3001ASD\u306e\u30ea\u30b9\u30af\u304c30\u301c50\uff05\u4f4e\u4e0b\u3057\u3066\u3044\u305f\u3068\u3059\u308b\u5831\u544a\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001\u3069\u306e\u6804\u990a\u7d20\u3092\u3001\u3069\u306e\u6642\u671f\u306b\u3001\u3069\u306e\u304f\u3089\u3044\u6442\u308b\u304b\u306b\u3088\u3063\u3066\u305d\u306e\u52b9\u679c\u306f\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u81ea\u5df1\u5224\u65ad\u306b\u983c\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u304b\u304b\u308a\u3064\u3051\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-clinic\/obgyn\/\">\u7523\u5a66\u4eba\u79d1<\/a>\u533b\u3084\u7ba1\u7406\u6804\u990a\u58eb\u3068\u76f8\u8ac7\u3057\u306a\u304c\u3089\u9032\u3081\u308b\u3053\u3068\u304c\u3068\u3066\u3082\u5927\u5207\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%83%93%E3%82%BF%E3%83%9F%E3%83%B3D%EF%BC%88Vitamin_D%EF%BC%89%EF%BC%9A%E5%A4%AA%E9%99%BD%E3%81%AE%E3%83%93%E3%82%BF%E3%83%9F%E3%83%B3%E3%81%8C%E6%94%AF%E3%81%88%E3%82%8B%E3%80%81%E7%99%BA%E9%81%94%E3%81%AE%E5%9C%9F%E5%8F%B0\"><\/span><strong>\u30d3\u30bf\u30df\u30f3D\uff08Vitamin D\uff09\uff1a\u592a\u967d\u306e\u30d3\u30bf\u30df\u30f3\u304c\u652f\u3048\u308b\u3001\u767a\u9054\u306e\u571f\u53f0<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\uff08vitamin D\uff09\u306f\u3001\u79c1\u305f\u3061\u304c\u65e5\u5149\u3092\u6d74\u3073\u308b\u3053\u3068\u3067\u76ae\u819a\u3067\u5408\u6210\u3055\u308c\u308b\u30d3\u30bf\u30df\u30f3\u3068\u3057\u3066\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u9aa8\u306e\u5065\u5eb7\u3084\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u5438\u53ce\u306b\u95a2\u308f\u308b\u6804\u990a\u7d20\u3068\u3044\u3046\u30a4\u30e1\u30fc\u30b8\u304c\u5f37\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u5b9f\u306f\u305d\u308c\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u514d\u75ab\u7cfb\uff08immune system\uff09\u3084\u8133\u306e\u767a\u9054\uff08brain development\uff09\u306b\u3082\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u3001\u3053\u3053\u5341\u6570\u5e74\u306e\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u598a\u5a20\u4e2d\u3001\u3042\u308b\u3044\u306f\u751f\u307e\u308c\u305f\u76f4\u5f8c\u306e\u8d64\u3061\u3083\u3093\u304c\u30d3\u30bf\u30df\u30f3D\u4e0d\u8db3\uff08vitamin D deficiency\uff09\u306e\u72b6\u614b\u306b\u3042\u308b\u3068\u3001ASD\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3059\u7814\u7a76\u3082\u3042\u308a\u307e\u3059\u3002\u4e00\u822c\u7684\u306b\u3001\u300c\u6b20\u4e4f\u300d\u3068\u3055\u308c\u308b\u306e\u306f\u3001\u8840\u4e2d25-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\uff08serum 25-hydroxyvitamin D concentration\uff09\u304c25\u30ca\u30ce\u30e2\u30eb\uff0f\u30ea\u30c3\u30c8\u30eb\uff08nmol\/L\uff09\u672a\u6e80\u306e\u3068\u304d\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u5f71\u97ff\u306f\u300c<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/#anchor_sex\">\u6027\u5225<\/a>\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u300d\u3068\u3059\u308b\u30c7\u30fc\u30bf\u3082\u51fa\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u30a2\u30e1\u30ea\u30ab\u306e\u5927\u898f\u6a21\u7814\u7a76\u3067\u3042\u308bCHARGE\uff08Childhood Autism Risks from Genetics and the Environment\uff09\u30b3\u30db\u30fc\u30c8\u3067\u306f\u3001\u5973\u306e\u5b50\u306b\u9650\u3063\u3066\u3001\u6bcd\u4f53\u306e\u30d3\u30bf\u30df\u30f3D\u30ec\u30d9\u30eb\u3068ASD\u306e\u30ea\u30b9\u30af\u3068\u306e\u3042\u3044\u3060\u306b\u4e88\u9632\u7684\u306a\u95a2\u9023\u304c\u898b\u3089\u308c\u305f\u3068\u3044\u3046\u5831\u544a\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u80ce\u5150\u306e\u8133\u305d\u306e\u3082\u306e\u306b\u50cd\u304d\u304b\u3051\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u514d\u75ab\u7cfb\u306e\u8abf\u6574\uff08immune regulation\uff09\u3084\u3001\u8133\u5185\u306e\u708e\u75c7\uff08neuroinflammation\uff09\u3092\u6291\u3048\u308b\u4f5c\u7528\u3082\u6301\u3064\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u591a\u69d8\u306a\u50cd\u304d\u304c\u3001\u795e\u7d4c\u767a\u9054\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u30d7\u30e9\u30b9\u306e\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u3059\u3067\u306bASD\u3068\u8a3a\u65ad\u3055\u308c\u305f\u304a\u5b50\u3055\u3093\u306b\u30d3\u30bf\u30df\u30f3D\u3092\u88dc\u7d66\uff08supplementation\uff09\u3057\u305f\u4e00\u90e8\u306e\u7814\u7a76\u3067\u306f\u3001\u793e\u4f1a\u7684\u306a\u3084\u308a\u3068\u308a\u3084\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u306e\u6539\u5584\u3068\u3044\u3063\u305f\u5909\u5316\u304c\u898b\u3089\u308c\u305f\u3068\u3044\u3046\u5831\u544a\u3082\u3042\u308a\u307e\u3059\u3002\u3068\u306f\u3044\u3048\u3001\u3059\u3079\u3066\u306e\u7814\u7a76\u3067\u540c\u3058\u3088\u3046\u306a\u7d50\u679c\u304c\u5f97\u3089\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u52b9\u679c\u306e\u5927\u304d\u3055\u3084\u73fe\u308c\u65b9\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4eba\u7a2e\u3084\u907a\u4f1d\u7684\u80cc\u666f\u306b\u3088\u3063\u3066\u3082\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u73fe\u6642\u70b9\u3067\u306f\u300c\u4e00\u5f8b\u306b\u52e7\u3081\u3089\u308c\u308b\u6a19\u6e96\u7642\u6cd5\u300d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001ASD\u306e\u304a\u5b50\u3055\u3093\u304c\u3059\u3067\u306b\u3044\u308b\u3054\u5bb6\u65cf\u306b\u304a\u3044\u3066\u306f\u3001\u598a\u5a20\u4e2d\u306b1\u65e5\u3042\u305f\u308a5,000\u56fd\u969b\u5358\u4f4d\uff08IU\uff1aInternational Units\uff09\u306e\u30d3\u30bf\u30df\u30f3D\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u6b21\u306e\u5b50\u3069\u3082\u304cASD\u3068\u8a3a\u65ad\u3055\u308c\u308b\u30ea\u30b9\u30af\u3092\u4e0b\u3052\u3089\u308c\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u3044\u3046\u7814\u7a76\u3082\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u307e\u3060\u691c\u8a3c\u6bb5\u968e\u306b\u3042\u308b\u4eee\u8aac\u3067\u3042\u308a\u3001\u81ea\u5df1\u5224\u65ad\u3067\u9ad8\u7528\u91cf\u3092\u6442\u308b\u306e\u306f\u907f\u3051\u3001\u5fc5\u305a\u533b\u5e2b\u306e\u6307\u5c0e\u306e\u3082\u3068\u3067\u884c\u3046\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%82%AA%E3%83%A1%E3%82%AC3%E8%84%82%E8%82%AA%E9%85%B8%EF%BC%88Omega-3_Fatty_Acids%EF%BC%89%EF%BC%9A%E7%A5%9E%E7%B5%8C%E3%81%AE%E7%99%BA%E9%81%94%E3%81%AB%E6%AC%A0%E3%81%8B%E3%81%9B%E3%81%AA%E3%81%84%E8%84%82%E8%B3%AA%E3%81%AE%E5%83%8D%E3%81%8D\"><\/span><strong>\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff08Omega-3 Fatty Acids\uff09\uff1a\u795e\u7d4c\u306e\u767a\u9054\u306b\u6b20\u304b\u305b\u306a\u3044\u8102\u8cea\u306e\u50cd\u304d<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff08omega-3 polyunsaturated fatty acids\uff09\u306f\u3001\u8102\u80aa\u306e\u4e00\u7a2e\u3067\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u8eab\u4f53\u306b\u3068\u3063\u3066\u6b20\u304b\u305b\u306a\u3044\u300c\u5fc5\u9808\u8102\u80aa\u9178\uff08essential fatty acids\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u6804\u990a\u7d20\u3067\u3059\u3002\u3068\u304f\u306b\u80ce\u5150\u671f\u3084\u4e73\u5150\u671f\u306b\u306f\u3001\u8133\u3084\u795e\u7d4c\u306e\u69cb\u9020\u304c\u6025\u901f\u306b\u5f62\u3065\u304f\u3089\u308c\u3066\u3044\u304f\u305f\u3081\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u306e\u5b58\u5728\u304c\u6975\u3081\u3066\u91cd\u8981\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4ee3\u8868\u7684\u306a\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u306b\u306f\u3001DHA\uff08docosahexaenoic acid\uff09\u3084EPA\uff08eicosapentaenoic acid\uff09\u306a\u3069\u304c\u3042\u308a\u3001\u3053\u308c\u3089\u306f\u9b5a\u6cb9\uff08fish oil\uff09\u3084\u4e00\u90e8\u306e\u690d\u7269\u7531\u6765\u30aa\u30a4\u30eb\u306b\u591a\u304f\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u598a\u5a20\u4e2d\u306e\u5973\u6027\u304c\u3053\u3046\u3057\u305f\u8102\u80aa\u9178\u3092\u3057\u3063\u304b\u308a\u3068\u6442\u53d6\u3057\u3066\u3044\u305f\u5834\u5408\u306b\u3001\u5b50\u3069\u3082\u306eASD\u30ea\u30b9\u30af\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u305f\u3068\u3059\u308b\u7814\u7a76\u3082\u3042\u308a\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u7d50\u679c\u306f\u7814\u7a76\u306b\u3088\u3063\u3066\u3070\u3089\u3064\u304d\u304c\u3042\u308a\u3001\u3059\u3079\u3066\u306e\u6bcd\u5b50\u96c6\u56e3\u3067\u4e00\u8cab\u3057\u305f\u52b9\u679c\u304c\u898b\u3089\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u4f53\u5185\u306b\u3042\u308b\u30aa\u30e1\u30ac6\u8102\u80aa\u9178\uff08omega-6 fatty acids\uff09\u3068\u306e\u30d0\u30e9\u30f3\u30b9\u3082\u91cd\u8981\u3060\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u4e8c\u3064\u306e\u8102\u80aa\u9178\u306f\u3001\u4f53\u5185\u3067\u4e92\u3044\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u5408\u3046\u95a2\u4fc2\u306b\u3042\u308a\u307e\u3059\u3002\u3068\u304f\u306b\u3001\u30aa\u30e1\u30ac3\uff1a\u30aa\u30e1\u30ac6\u306e\u6bd4\u7387\uff08n-3:n-6 ratio\uff09\u304c\u4f4e\u3059\u304e\u308b\u5834\u5408\u306b\u306f\u3001\u708e\u75c7\u53cd\u5fdc\uff08inflammatory response\uff09\u304c\u9ad8\u307e\u308a\u3084\u3059\u304f\u306a\u308a\u3001\u8133\u5185\u306e\u74b0\u5883\u304c\u795e\u7d4c\u767a\u9054\u306b\u3068\u3063\u3066\u671b\u307e\u3057\u304f\u306a\u3044\u72b6\u614b\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5b9f\u969b\u306b\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\uff08omega-3 supplements\uff09\u3092\u7528\u3044\u305f\u7814\u7a76\u306e\u306a\u304b\u306b\u306f\u3001ASD\u306e\u304a\u5b50\u3055\u3093\u306e\u591a\u52d5\u6027\uff08hyperactivity\uff09\u3084\u53cd\u5fa9\u884c\u52d5\uff08repetitive behavior\uff09\u304c\u3084\u308f\u3089\u3044\u3060\u3068\u3044\u3046\u5831\u544a\u3082\u3042\u308a\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u305d\u306e\u52b9\u679c\u306e\u5927\u304d\u3055\u306f\u9650\u5b9a\u7684\u3067\u3042\u308a\u3001\u7d71\u8a08\u7684\u306b\u6709\u610f\u306a\u5dee\u304c\u898b\u3089\u308c\u305f\u7814\u7a76\u306f\u307e\u3060\u5c11\u6570\u3067\u3059\u3002\u7814\u7a76\u306e\u898f\u6a21\u304c\u5c0f\u3055\u3044\u3001\u307e\u305f\u306f\u53c2\u52a0\u8005\u306e\u3070\u3089\u3064\u304d\u304c\u5927\u304d\u3044\u3068\u3044\u3063\u305f\u8ab2\u984c\u3082\u3042\u308a\u3001\u73fe\u6642\u70b9\u3067\u306f\u300c\u88dc\u52a9\u7684\u306a\u5bfe\u5fdc\u300d\u3068\u3057\u3066\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u308c\u3067\u3082\u3001\u98df\u751f\u6d3b\u306e\u306a\u304b\u3067\u7121\u7406\u306a\u304f\u53d6\u308a\u5165\u308c\u3089\u308c\u308b\u6804\u990a\u7d20\u3067\u3042\u308a\u3001\u80ce\u5150\u3084\u4e73\u5150\u306e\u8133\u306e\u5065\u5eb7\u3092\u652f\u3048\u308b\u3068\u3044\u3046\u89b3\u70b9\u304b\u3089\u3082\u3001\u598a\u5a20\u4e2d\u306e\u98df\u4e8b\u306b\u6c17\u3092\u914d\u308b\u3046\u3048\u3067\u6ce8\u76ee\u3059\u3079\u304d\u6804\u990a\u7d20\u306e\u4e00\u3064\u3068\u3044\u3048\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%AB%98%E8%84%82%E8%82%AA%E9%A3%9F%EF%BC%88High-Fat_Diet%EF%BC%89%EF%BC%9A%E6%AF%8D%E4%BD%93%E3%81%AE%E9%A3%9F%E4%BA%8B%E3%81%8C%E8%84%B3%E3%81%AB%E4%B8%8E%E3%81%88%E3%82%8B%E5%BD%B1%E9%9F%BF\"><\/span><strong>\u9ad8\u8102\u80aa\u98df\uff08High-Fat Diet\uff09\uff1a\u6bcd\u4f53\u306e\u98df\u4e8b\u304c\u8133\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u598a\u5a20\u4e2d\u3001\u3068\u304f\u306b\u598a\u5a20\u306e\u521d\u671f\u306b\u9ad8\u8102\u80aa\u98df\uff08high-fat diet\uff09\u3092\u591a\u304f\u6442\u53d6\u3057\u3066\u3044\u305f\u6bcd\u89aa\u3067\u306f\u3001\u305d\u306e\u5b50\u3069\u3082\u304c\u5c06\u6765\u7684\u306bASD\u3068\u8a3a\u65ad\u3055\u308c\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3059\u308b\u7814\u7a76\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u3053\u3067\u3044\u3046\u300c\u9ad8\u8102\u80aa\u98df\u300d\u3068\u306f\u3001\u30d5\u30a1\u30b9\u30c8\u30d5\u30fc\u30c9\u3084\u52a0\u5de5\u98df\u54c1\u306b\u504f\u3063\u305f\u98df\u751f\u6d3b\u3092\u6307\u3059\u3053\u3068\u304c\u591a\u304f\u3001\u904e\u5270\u306a\u8102\u8cea\u6442\u53d6\u306b\u3088\u3063\u3066\u4f53\u5185\u306e\u708e\u75c7\u53cd\u5fdc\uff08inflammatory response\uff09\u3084\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u304c\u4e71\u308c\u308b\u3053\u3068\u304c\u61f8\u5ff5\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u3046\u3057\u305f\u5f71\u97ff\u306f\u3001\u6bcd\u4f53\u3060\u3051\u3067\u306a\u304f\u3001\u80ce\u5150\u306e\u8133\u3084\u795e\u7d4c\u306e\u767a\u9054\u306b\u3082\u53ca\u3076\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u514d\u75ab\u306e\u8abf\u6574\u7269\u8cea\u3067\u3042\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08cytokines\uff09\u304c\u5909\u52d5\u3057\u3001\u305d\u308c\u304c\u80ce\u5150\u306e\u795e\u7d4c\u4f1d\u9054\u7cfb\uff08neurotransmitter systems\uff09\u306b\u4f5c\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u8133\u306e\u767a\u9054\u306b\u601d\u308f\u306c\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30e9\u30c3\u30c8\u3092\u7528\u3044\u305f\u52d5\u7269\u5b9f\u9a13\uff08animal model studies\uff09\u3067\u3082\u3001\u598a\u5a20\u4e2d\u306b\u9ad8\u8102\u80aa\u98df\u3092\u4e0e\u3048\u305f\u6bcd\u89aa\u304b\u3089\u751f\u307e\u308c\u305f\u5b50\u3069\u3082\u3001\u3068\u304f\u306b\u601d\u6625\u671f\u306e\u96c4\uff08male offspring\uff09\u306b\u304a\u3044\u3066\u3001ASD\u3068\u95a2\u4fc2\u304c\u3042\u308b\u3068\u3055\u308c\u308b\u907a\u4f1d\u5b50\uff08genes\uff09\u2014\u2014\u305f\u3068\u3048\u3070\u3001Shank1\u3001Setd1b\u3001Taok2\u306a\u3069\u2014\u2014\u306e\u767a\u73fe\u306b\u7570\u5e38\u304c\u898b\u3089\u308c\u305f\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u98df\u4e8b\u304c\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u65b9\uff08gene expression\uff09\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u300c\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\uff08epigenetics\uff09\u300d\u306e\u4e00\u4f8b\u3068\u3057\u3066\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3082\u3061\u308d\u3093\u3001\u3053\u3046\u3057\u305f\u7814\u7a76\u306f\u52d5\u7269\u5b9f\u9a13\u306b\u57fa\u3065\u304f\u3082\u306e\u3067\u3042\u308a\u3001\u305d\u306e\u307e\u307e\u4eba\u9593\u306b\u5f53\u3066\u306f\u307e\u308b\u3068\u306f\u9650\u308a\u307e\u305b\u3093\u304c\u3001\u300c\u6bcd\u4f53\u306e\u6804\u990a\u72b6\u614b\u304c\u3001\u80ce\u5150\u306e\u795e\u7d4c\u7cfb\u306b\u6df1\u304f\u95a2\u308f\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u300d\u3068\u3044\u3046\u70b9\u3067\u306f\u3001\u4eba\u306b\u3068\u3063\u3066\u3082\u7121\u8996\u3067\u304d\u306a\u3044\u793a\u5506\u3092\u542b\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%A6%8A%E5%A8%A0%E7%94%A8%E3%83%93%E3%82%BF%E3%83%9F%E3%83%B3%E3%81%A8%E3%83%9E%E3%83%AB%E3%83%81%E3%83%93%E3%82%BF%E3%83%9F%E3%83%B3%EF%BC%88Prenatal_and_Multivitamin_Supplements%EF%BC%89%EF%BC%9A%E9%81%8E%E4%B8%8D%E8%B6%B3%E3%81%AA%E3%81%8F%E3%80%81%E3%83%90%E3%83%A9%E3%83%B3%E3%82%B9%E3%82%92%E6%84%8F%E8%AD%98%E3%81%97%E3%81%A6\"><\/span><strong>\u598a\u5a20\u7528\u30d3\u30bf\u30df\u30f3\u3068\u30de\u30eb\u30c1\u30d3\u30bf\u30df\u30f3\uff08Prenatal and Multivitamin Supplements\uff09\uff1a\u904e\u4e0d\u8db3\u306a\u304f\u3001\u30d0\u30e9\u30f3\u30b9\u3092\u610f\u8b58\u3057\u3066<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u598a\u5a20\u4e2d\u306e\u6bcd\u89aa\u304c\u3001\u8449\u9178\uff08folic acid\uff09\u3084\u9244\u5206\uff08iron\uff09\u306a\u3069\u3092\u542b\u3093\u3060\u598a\u5a20\u7528\u30d3\u30bf\u30df\u30f3\uff08prenatal vitamins\uff09\u3092\u7d99\u7d9a\u7684\u306b\u6442\u53d6\u3057\u3066\u3044\u305f\u5834\u5408\u3001ASD\u306e\u30ea\u30b9\u30af\u304c30\u301c50\uff05\u7a0b\u5ea6\u4f4e\u4e0b\u3057\u3066\u3044\u305f\u3068\u3059\u308b\u5927\u898f\u6a21\u306a\u30b3\u30db\u30fc\u30c8\u7814\u7a76\uff08cohort studies\uff09\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u7d50\u679c\u306f\u4e3b\u306b\u30a2\u30e1\u30ea\u30ab\u306e\u7814\u7a76\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u304c\u3001\u65e5\u672c\u3092\u542b\u3081\u305f\u4ed6\u56fd\u306e\u7814\u7a76\u3067\u3082\u540c\u69d8\u306e\u50be\u5411\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001\u3059\u3079\u3066\u306e\u30de\u30eb\u30c1\u30d3\u30bf\u30df\u30f3\uff08multivitamin supplements\uff09\u304c\u540c\u3058\u3088\u3046\u306a\u52b9\u679c\u3092\u6301\u3064\u3068\u306f\u9650\u308a\u307e\u305b\u3093\u3002\u4e00\u90e8\u306e\u7814\u7a76\u3067\u306f\u3001\u30de\u30eb\u30c1\u30d3\u30bf\u30df\u30f3\u306e\u6442\u53d6\u91cf\u304c\u591a\u3059\u304e\u3066\u3082\u5c11\u306a\u3059\u304e\u3066\u3082ASD\u30ea\u30b9\u30af\u304c\u4e0a\u6607\u3059\u308b\u3068\u3044\u3046\u3001\u300cU\u5b57\u578b\uff08U-shaped relationship\uff09\u300d\u306e\u7d50\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u6210\u5206\u306e\u5185\u5bb9\u3084\u6442\u53d6\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u304c\u9375\u3092\u63e1\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u300c\u3044\u3044\u3053\u3068\u3060\u304b\u3089\u305f\u304f\u3055\u3093\u53d6\u308d\u3046\u300d\u3067\u306f\u306a\u304f\u3001\u300c\u5fc5\u8981\u306a\u5206\u3092\u3001\u9069\u5207\u306a\u6642\u671f\u306b\u3001\u30d0\u30e9\u30f3\u30b9\u3088\u304f\u53d6\u308a\u5165\u308c\u308b\u300d\u3068\u3044\u3046\u8996\u70b9\u304c\u3068\u3066\u3082\u5927\u5207\u3067\u3059\u3002\u3054\u81ea\u8eab\u3084\u3054\u5bb6\u65cf\u306e\u4f53\u8cea\u3084\u65e2\u5f80\u6b74\u306b\u5408\u308f\u305b\u3066\u3001\u4e3b\u6cbb\u533b\u3084\u7ba1\u7406\u6804\u990a\u58eb\u3068\u76f8\u8ac7\u3057\u306a\u304c\u3089\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u9078\u3076\u3053\u3068\u3092\u304a\u3059\u3059\u3081\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%81%9D%E3%81%AE%E4%BB%96%E3%81%AE%E6%A0%84%E9%A4%8A%E7%B4%A0%E3%81%A8%E3%81%9D%E3%81%AE%E5%BD%B1%E9%9F%BF\"><\/span><strong>\u305d\u306e\u4ed6\u306e\u6804\u990a\u7d20\u3068\u305d\u306e\u5f71\u97ff<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u9244\u5206\uff08Iron\uff09<\/strong><\/h4>\n\n\n\n<p>\u598a\u5a20\u521d\u671f\u304b\u3089\u6388\u4e73\u671f\u306b\u304b\u3051\u3066\u3001\u9244\u5206\u304c\u4e0d\u8db3\u3057\u306a\u3044\u3088\u3046\u306b\u6ce8\u610f\u3059\u308b\u3053\u3068\u306f\u3001\u80ce\u5150\u306e\u795e\u7d4c\u767a\u9054\u306b\u3068\u3063\u3066\u3082\u91cd\u8981\u3067\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001\u598a\u5a20\u4e2d\u306b\u5341\u5206\u306a\u9244\u3092\u6442\u53d6\u3057\u3066\u3044\u305f\u6bcd\u89aa\u306e\u5b50\u3069\u3082\u3067\u3001ASD\u306e\u767a\u75c7\u7387\u304c\u4f4e\u304b\u3063\u305f\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u598a\u5a2030\u9031\u307e\u3067\u306b\u598a\u5a20\u6027\u8ca7\u8840\uff08gestational anemia\uff09\u3068\u8a3a\u65ad\u3055\u308c\u305f\u5834\u5408\u3001\u304b\u3048\u3063\u3066ASD\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3068\u3044\u3046\u30c7\u30fc\u30bf\u3082\u3042\u308a\u3001\u30bf\u30a4\u30df\u30f3\u30b0\u3068\u7d99\u7d9a\u6027\u304c\u91cd\u8981\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30d3\u30bf\u30df\u30f3B12\uff08Vitamin B12\uff09<\/strong><\/h4>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3B12\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306e\u6a5f\u80fd\u3084DNA\u5408\u6210\u306b\u95a2\u308f\u308b\u6804\u990a\u7d20\u3067\u3059\u3002\u9ad8\u3044\u8840\u4e2d\u30d3\u30bf\u30df\u30f3B12\u6fc3\u5ea6\uff08elevated serum B12 levels\uff09\u304cASD\u306e\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3068\u3044\u3046\u7814\u7a76\u3082\u3042\u308a\u307e\u3059\u304c\u3001\u5168\u4f53\u3068\u3057\u3066\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u307e\u3060\u9650\u3089\u308c\u3066\u304a\u308a\u3001\u73fe\u6bb5\u968e\u3067\u660e\u78ba\u306a\u7d50\u8ad6\u3092\u51fa\u3059\u306b\u306f\u60c5\u5831\u304c\u4e0d\u8db3\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30ab\u30eb\u30b7\u30a6\u30e0\u3068\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\uff08Calcium and Magnesium\uff09<\/strong><\/h4>\n\n\n\n<p>\u598a\u5a20\u524d\u306b\u30ab\u30eb\u30b7\u30a6\u30e0\u3092\u88dc\u3046\u3053\u3068\u3067ASD\u306e\u30ea\u30b9\u30af\u304c\u4e0b\u304c\u3063\u305f\u3068\u3059\u308b\u7814\u7a76\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u306b\u3064\u3044\u3066\u306f\u3001\u65b0\u751f\u5150\u306e\u8840\u4e2d\u6fc3\u5ea6\u3068\u306e\u3042\u3044\u3060\u306b\u6709\u610f\u306a\u95a2\u9023\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u3001\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u98df\u4e8b\u3092\u901a\u3058\u3066\u3053\u308c\u3089\u306e\u30df\u30cd\u30e9\u30eb\u3092\u6442\u308b\u3053\u3068\u304c\u3001\u795e\u7d4c\u767a\u9054\u306b\u3068\u3063\u3066\u671b\u307e\u3057\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u4eba\u5de5\u7518\u5473\u6599\u3068\u30e1\u30bf\u30ce\u30fc\u30eb\uff08Artificial Sweeteners and Methanol\uff09<\/strong><\/h4>\n\n\n\n<p>\u4e00\u90e8\u306e\u5f8c\u308d\u5411\u304d\u7814\u7a76\uff08retrospective studies\uff09\u3067\u306f\u3001\u4eba\u5de5\u7518\u5473\u6599\u3067\u3042\u308b\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\uff08aspartame\uff09\u3084\u3001\u305d\u306e\u4ee3\u8b1d\u7269\u3067\u3042\u308b\u30e1\u30bf\u30ce\u30fc\u30eb\uff08methanol\uff09\u306e\u6442\u53d6\u304cASD\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u3053\u3046\u3057\u305f\u7814\u7a76\u3067\u306f\u3001\u6442\u53d6\u91cf\u3092\u601d\u3044\u51fa\u3057\u3066\u7533\u544a\u3059\u308b\u5f62\u5f0f\u304c\u591a\u304f\u3001\u300c\u8a18\u61b6\u306e\u504f\u308a\uff08recall bias\uff09\u300d\u3068\u3044\u3063\u305f\u9650\u754c\u3082\u3042\u308b\u305f\u3081\u3001\u56e0\u679c\u95a2\u4fc2\u304c\u8a3c\u660e\u3055\u308c\u305f\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%A0%84%E9%A4%8A%E7%AE%A1%E7%90%86%E6%B3%95%EF%BC%88Dietary_Approaches%EF%BC%89%EF%BC%9A%E6%97%A5%E3%80%85%E3%81%AE%E9%A3%9F%E4%BA%8B%E3%81%8C%E5%BF%83%E3%81%A8%E4%BD%93%E3%81%AB%E3%81%A7%E3%81%8D%E3%82%8B%E3%81%93%E3%81%A8\"><\/span><strong>\u6804\u990a\u7ba1\u7406\u6cd5\uff08Dietary Approaches\uff09\uff1a\u65e5\u3005\u306e\u98df\u4e8b\u304c\u5fc3\u3068\u4f53\u306b\u3067\u304d\u308b\u3053\u3068<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>ASD\u306e\u304a\u5b50\u3055\u3093\u306e\u75c7\u72b6\u3092\u5c11\u3057\u3067\u3082\u3084\u308f\u3089\u3052\u305f\u3044\u3001\u65e5\u5e38\u751f\u6d3b\u3092\u5c11\u3057\u3067\u3082\u697d\u306b\u3057\u305f\u3044\u3002\u305d\u3046\u9858\u3046\u3054\u5bb6\u65cf\u306e\u306a\u304b\u306b\u306f\u3001\u98df\u4e8b\u306b\u3088\u3063\u3066\u4f55\u304b\u3067\u304d\u308b\u3053\u3068\u304c\u306a\u3044\u304b\u3068\u63a2\u3055\u308c\u3066\u3044\u308b\u65b9\u3082\u591a\u3044\u304b\u3068\u601d\u3044\u307e\u3059\u3002\u8fd1\u5e74\u3067\u306f\u3001ASD\u306b\u95a2\u9023\u3059\u308b\u3068\u3055\u308c\u308b\u884c\u52d5\u3084\u6d88\u5316\u5668\u75c7\u72b6\u306b\u5bfe\u3057\u3066\u3001\u7279\u5b9a\u306e\u300c\u9664\u53bb\u98df\uff08elimination diets\uff09\u300d\u3084\u300c\u98df\u4e8b\u30d1\u30bf\u30fc\u30f3\u306e\u8abf\u6574\uff08dietary pattern modification\uff09\u300d\u304c\u6709\u52b9\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u5831\u544a\u304c\u3044\u304f\u3064\u304b\u51fa\u3066\u304d\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30b0\u30eb\u30c6\u30f3\u30fb\u30ab\u30bc\u30a4\u30f3\u9664\u53bb\u98df\uff08Gluten-Free, Casein-Free Diet\uff09<\/strong><\/h4>\n\n\n\n<p>\u300c\u30b0\u30eb\u30c6\u30f3\uff08gluten\uff09\u300d\u306f\u5c0f\u9ea6\u306b\u542b\u307e\u308c\u308b\u305f\u3093\u3071\u304f\u8cea\u3001\u300c\u30ab\u30bc\u30a4\u30f3\uff08casein\uff09\u300d\u306f\u725b\u4e73\u3084\u4e73\u88fd\u54c1\u306b\u542b\u307e\u308c\u308b\u305f\u3093\u3071\u304f\u8cea\u3067\u3059\u3002\u3053\u308c\u3089\u3092\u53d6\u308a\u9664\u3044\u305f\u98df\u4e8b\u3001\u3044\u308f\u3086\u308b\u300cGFCF\u98df\uff08gluten-free, casein-free diet\uff09\u300d\u304c\u3001ASD\u306e\u304a\u5b50\u3055\u3093\u306e\u884c\u52d5\u306b\u826f\u3044\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3059\u308b\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002\u4e2d\u306b\u306f\u3001\u53cd\u5fa9\u884c\u52d5\u304c\u8efd\u304f\u306a\u3063\u305f\u308a\u3001\u7761\u7720\u304c\u5b89\u5b9a\u3057\u305f\u308a\u3057\u305f\u3068\u3044\u3046\u4fdd\u8b77\u8005\u306e\u58f0\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u591a\u304f\u306e\u7814\u7a76\u3067\u306f\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\uff08placebo-controlled study\uff09\u3084\u4e8c\u91cd\u76f2\u691c\u6cd5\uff08\u4e8c\u91cd\u76f2\u691c\u8a66\u9a13\uff1adouble-blind trials\uff09\u304c\u7528\u3044\u3089\u308c\u3066\u304a\u3089\u305a\u3001\u4fe1\u983c\u6027\u306b\u306f\u9650\u754c\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u3059\u3079\u3066\u306e\u304a\u5b50\u3055\u3093\u306b\u5f53\u3066\u306f\u307e\u308b\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u7279\u5b9a\u306e\u4f53\u8cea\u3084\u8178\u5185\u74b0\u5883\u3092\u6301\u3064\u304a\u5b50\u3055\u3093\u306b\u306e\u307f\u52b9\u679c\u304c\u898b\u3089\u308c\u305f\u53ef\u80fd\u6027\u3082\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30b1\u30c8\u30b8\u30a7\u30cb\u30c3\u30af\u30fb\u30c0\u30a4\u30a8\u30c3\u30c8\uff08Ketogenic Diet\uff09<\/strong><\/h4>\n\n\n\n<p>\u300c\u30b1\u30c8\u30b8\u30a7\u30cb\u30c3\u30af\u30fb\u30c0\u30a4\u30a8\u30c3\u30c8\uff08ketogenic diet\uff09\u300d\u3068\u306f\u3001\u70ad\u6c34\u5316\u7269\uff08carbohydrates\uff09\u3092\u6975\u7aef\u306b\u6e1b\u3089\u3057\u3001\u4ee3\u308f\u308a\u306b\u8102\u80aa\u3092\u591a\u304f\u6442\u53d6\u3059\u308b\u3068\u3044\u3046\u98df\u4e8b\u6cd5\u3067\u3001\u3082\u3068\u3082\u3068\u306f\u3066\u3093\u304b\u3093\u306e\u6cbb\u7642\u306e\u4e00\u74b0\u3068\u3057\u3066\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002ASD\u3068\u3066\u3093\u304b\u3093\u306e\u4e21\u65b9\u3092\u6301\u3064\u304a\u5b50\u3055\u3093\u306b\u5bfe\u3057\u3066\u3053\u306e\u98df\u4e8b\u6cd5\u3092\u5c0e\u5165\u3057\u305f\u3068\u3053\u308d\u3001\u8a8d\u77e5\u6a5f\u80fd\uff08cognitive function\uff09\u3084\u884c\u52d5\u9762\u306e\u6539\u5584\u304c\u898b\u3089\u308c\u305f\u3068\u3044\u3046\u5831\u544a\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u3084\u6804\u990a\u30d0\u30e9\u30f3\u30b9\u306b\u504f\u308a\u304c\u751f\u3058\u3084\u3059\u3044\u98df\u4e8b\u6cd5\u3067\u3042\u308b\u305f\u3081\u3001\u9577\u671f\u7684\u306a\u5b9f\u65bd\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002\u307e\u305f\u3001\u5927\u898f\u6a21\u306a\u81e8\u5e8a\u8a66\u9a13\uff08large-scale clinical trials\uff09\u306f\u307e\u3060\u5b9f\u65bd\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u3059\u3050\u306b\u5e83\u304f\u63a8\u5968\u3067\u304d\u308b\u6bb5\u968e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u5730\u4e2d\u6d77\u5f0f\u98df\u4e8b\uff08Mediterranean Diet\uff09<\/strong><\/h4>\n\n\n\n<p>\u300c\u5730\u4e2d\u6d77\u5f0f\u98df\u4e8b\uff08Mediterranean diet\uff09\u300d\u306f\u3001\u9b5a\u3001\u91ce\u83dc\u3001\u679c\u7269\u3001\u5168\u7c92\u7a40\u7269\u3001\u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u306a\u3069\u3092\u4e2d\u5fc3\u306b\u3057\u305f\u98df\u751f\u6d3b\u30b9\u30bf\u30a4\u30eb\u3067\u3001\u5fc3\u81d3\u75c5\u3084\u7cd6\u5c3f\u75c5\u306e\u4e88\u9632\u306b\u5f79\u7acb\u3064\u98df\u4e8b\u6cd5\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u598a\u5a20\u4e2d\u306b\u3053\u306e\u98df\u4e8b\u30b9\u30bf\u30a4\u30eb\u3092\u7dad\u6301\u3057\u3066\u3044\u305f\u6bcd\u89aa\u304b\u3089\u751f\u307e\u308c\u305f\u5b50\u3069\u3082\u3067\u306f\u3001ASD\u306b\u95a2\u9023\u3059\u308b\u50be\u5411\uff08social responsiveness\u306a\u3069\uff09\u304c\u4f4e\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u7814\u7a76\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001\u3053\u3046\u3057\u305f\u30c7\u30fc\u30bf\u306f\u307e\u3060\u9650\u5b9a\u7684\u3067\u3042\u308a\u3001\u6587\u5316\u7684\u80cc\u666f\u3084\u907a\u4f1d\u7684\u8981\u56e0\u3001\u98df\u751f\u6d3b\u5168\u4f53\u306e\u8cea\u306a\u3069\u304c\u8907\u96d1\u306b\u7d61\u307f\u5408\u3063\u3066\u3044\u308b\u305f\u3081\u3001\u56e0\u679c\u95a2\u4fc2\u306e\u78ba\u5b9a\u306b\u306f\u81f3\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u305d\u308c\u3067\u3082\u3001\u300c\u504f\u308a\u306e\u306a\u3044\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u98df\u4e8b\u300d\u304c\u3001\u795e\u7d4c\u767a\u9054\u306b\u826f\u3044\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u70b9\u306f\u3001\u5e83\u304f\u652f\u6301\u3055\u308c\u3066\u3044\u308b\u5171\u901a\u8a8d\u8b58\u3068\u8a00\u3048\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%83%97%E3%83%AD%E3%83%90%E3%82%A4%E3%82%AA%E3%83%86%E3%82%A3%E3%82%AF%E3%82%B9%E3%81%A8%E8%85%B8%E2%80%93%E8%84%B3%E8%BB%B8%EF%BC%88Gut_Microbiota_and_the_Gut%E2%80%93Brain_Axis%EF%BC%89%EF%BC%9A%E3%81%8A%E8%85%B9%E3%81%AE%E5%81%A5%E5%BA%B7%E3%81%A8%E5%BF%83%E3%81%AE%E3%81%A4%E3%81%AA%E3%81%8C%E3%82%8A\"><\/span><strong>\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u3068\u8178\u2013\u8133\u8ef8\uff08Gut Microbiota and the Gut\u2013Brain Axis\uff09\uff1a\u304a\u8179\u306e\u5065\u5eb7\u3068\u5fc3\u306e\u3064\u306a\u304c\u308a<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u8fd1\u5e74\u3001ASD\u306b\u95a2\u9023\u3059\u308b\u7814\u7a76\u306e\u4e2d\u3067\u3001\u7279\u306b\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u308b\u9818\u57df\u306e\u3072\u3068\u3064\u304c\u3001\u300c\u8178\u5185\u7d30\u83cc\u53e2\uff08gut microbiota\uff09\u300d\u3068\u300c\u8133\u306e\u767a\u9054\u30fb\u6a5f\u80fd\u3068\u306e\u3064\u306a\u304c\u308a\uff08gut\u2013brain axis\uff09\u300d\u306b\u95a2\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u79c1\u305f\u3061\u306e\u8178\u5185\u306b\u306f\u3001\u6570\u767e\u5146\u3068\u3082\u3044\u308f\u308c\u308b\u5fae\u751f\u7269\uff08microorganisms\uff09\u304c\u751f\u606f\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306f\u5358\u306b\u98df\u3079\u7269\u3092\u5206\u89e3\u30fb\u5438\u53ce\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u514d\u75ab\u6a5f\u80fd\u3084\u795e\u7d4c\u7cfb\u306e\u767a\u9054\u3001\u3055\u3089\u306b\u306f\u884c\u52d5\u3084\u611f\u60c5\u306e\u8abf\u6574\u306b\u307e\u3067\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3068\u308a\u308f\u3051\u3001ASD\u306e\u304a\u5b50\u3055\u3093\u306b\u304a\u3051\u308b\u8178\u5185\u7d30\u83cc\u306e\u69cb\u6210\uff08microbiota profile\uff09\u306f\u3001\u767a\u9054\u306e\u5178\u578b\u3092\u793a\u3059\u304a\u5b50\u3055\u3093\u3068\u306f\u7570\u306a\u308b\u50be\u5411\u304c\u3042\u308b\u3053\u3068\u304c\u3001\u3044\u304f\u3064\u304b\u306e\u7814\u7a76\u306b\u3088\u3063\u3066\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u5909\u5316\u304c\u89b3\u5bdf\u3055\u308c\u3066\u3044\u307e\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5897\u52a0\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u83cc\u7a2e<\/strong>\uff1aClostridium\uff08\u30af\u30ed\u30b9\u30c8\u30ea\u30b8\u30a6\u30e0\u5c5e\uff09\u3001Bacteroidetes\uff08\u30d0\u30af\u30c6\u30ed\u30a4\u30c7\u30b9\u9580\uff09\u3001Desulfovibrio\u3001Lactobacillus\uff08\u30e9\u30af\u30c8\u30d0\u30c1\u30eb\u30b9\u5c5e\uff09\u306a\u3069<br><\/li>\n\n\n\n<li><strong>\u6e1b\u5c11\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u83cc\u7a2e<\/strong>\uff1aBifidobacterium\uff08\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\uff09\u3001Firmicutes\uff08\u30d5\u30a1\u30fc\u30df\u30ad\u30e5\u30fc\u30c6\u30b9\u9580\uff09\u3001Prevotella\uff08\u30d7\u30ec\u30dc\u30c6\u30e9\u5c5e\uff09\u306a\u3069<\/li>\n<\/ul>\n\n\n\n<div style=\"height:24px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u3046\u3057\u305f\u8178\u5185\u7d30\u83cc\u53e2\u306e\u4e0d\u5747\u8861\uff08dysbiosis\uff09\u306f\u3001\u4fbf\u79d8\u3084\u8179\u90e8\u306e\u4e0d\u5feb\u611f\u3001\u4e0b\u75e2\u3068\u3044\u3063\u305f\u6d88\u5316\u5668\u75c7\u72b6\u3068\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u611f\u899a\u306e\u904e\u654f\u3055\uff08sensory sensitivity\uff09\u3084\u53cd\u5fa9\u884c\u52d5\u3001\u793e\u4f1a\u7684\u306a\u5fdc\u7b54\u6027\u3068\u3044\u3063\u305fASD\u306e\u884c\u52d5\u7279\u5fb4\u3068\u3082\u95a2\u9023\u304c\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001Clostridium\u5c5e\u306e\u4e00\u90e8\u306e\u83cc\u306f\u3001\u795e\u7d4c\u306b\u4f5c\u7528\u3059\u308b\u4ee3\u8b1d\u7523\u7269\u3084\u708e\u75c7\u6027\u7269\u8cea\u3092\u7523\u751f\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u304c\u795e\u7d4c\u767a\u9054\u306b\u6709\u5bb3\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u3082\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8178\u5185\u7d30\u83cc\u304c\u8133\u306e\u767a\u9054\u3084\u50cd\u304d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u7d4c\u8def\u306f\u300c\u8178\u2013\u8133\u8ef8\uff08gut\u2013brain axis\uff09\u300d\u3068\u547c\u3070\u308c\u3001\u3044\u304f\u3064\u304b\u306e\u751f\u7269\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u63d0\u5531\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e3b\u306a\u7d4c\u8def\u3068\u3057\u3066\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u6319\u3052\u3089\u308c\u307e\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u77ed\u9396\u8102\u80aa\u9178\uff08Short-chain fatty acids, SCFAs\uff09<\/strong>\uff1a\u8178\u5185\u7d30\u83cc\u304c\u98df\u7269\u7e4a\u7dad\u3092\u767a\u9175\u3055\u305b\u308b\u3053\u3068\u3067\u751f\u6210\u3055\u308c\u308bSCFA\u3001\u7279\u306b\u916a\u9178\uff08butyrate\uff09\u306a\u3069\u306f\u3001\u8133\u5185\u306e\u708e\u75c7\u3092\u6291\u3048\u308b\u6297\u708e\u75c7\u4f5c\u7528\u3092\u6301\u3064\u3068\u3055\u308c\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u7523\u751f\u8abf\u7bc0<\/strong>\uff1a\u8178\u5185\u3067\u306e\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3\u4ee3\u8b1d\u3092\u901a\u3058\u3066\u3001\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3067\u3042\u308b\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u5408\u6210\u304c\u8abf\u6574\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u8840\u6db2\u8133\u95a2\u9580\u306e\u900f\u904e\u6027\u306e\u5909\u5316<\/strong>\uff1a\u7d30\u83cc\u306e\u4ee3\u8b1d\u7523\u7269\u304c\u8840\u6db2\u8133\u95a2\u9580\uff08blood\u2013brain barrier\uff09\u306b\u4f5c\u7528\u3057\u3001\u6709\u5bb3\u7269\u8cea\u3084\u514d\u75ab\u5206\u5b50\u306e\u8133\u5185\u4fb5\u5165\u3092\u4fc3\u9032\u307e\u305f\u306f\u9632\u5fa1\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u8ff7\u8d70\u795e\u7d4c\uff08vagus nerve\uff09\u3092\u4ecb\u3057\u305f\u4fe1\u53f7\u4f1d\u9054<\/strong>\uff1a\u8178\u3068\u8133\u3092\u76f4\u63a5\u3064\u306a\u3050\u4e3b\u8981\u306a\u795e\u7d4c\u7d4c\u8def\u3092\u901a\u3058\u3066\u3001\u8178\u5185\u74b0\u5883\u306e\u5909\u5316\u304c\u8133\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:24px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u3046\u3057\u305f\u77e5\u898b\u3092\u80cc\u666f\u306b\u3001\u8178\u5185\u74b0\u5883\u3092\u6574\u3048\u308b\u3053\u3068\u306b\u3088\u3063\u3066ASD\u306b\u95a2\u9023\u3059\u308b\u75c7\u72b6\u304c\u6539\u5584\u3059\u308b\u53ef\u80fd\u6027\u306b\u6ce8\u76ee\u304c\u96c6\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u3068\u304f\u306b\u3001\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08probiotics\uff09\u306e\u6442\u53d6\u306b\u3088\u308a\u3001\u8178\u5185\u306e\u5584\u7389\u83cc\u30d0\u30e9\u30f3\u30b9\u3092\u56de\u5fa9\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u795e\u7d4c\u708e\u75c7\uff08neuroinflammation\uff09\u306e\u6291\u5236\u3084\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u4ee3\u8b1d\u306e\u6b63\u5e38\u5316\u3001SCFA\u7523\u751f\u306e\u4fc3\u9032\u3001\u3055\u3089\u306b\u306f\u8ff7\u8d70\u795e\u7d4c\u3092\u901a\u3058\u305f\u8133\u3078\u306e\u30dd\u30b8\u30c6\u30a3\u30d6\u306a\u4fe1\u53f7\u4f1d\u9054\u306a\u3069\u3001\u8907\u6570\u306e\u7d4c\u8def\u3092\u901a\u3058\u3066\u884c\u52d5\u3084\u60c5\u52d5\u3001\u6d88\u5316\u6a5f\u80fd\u306b\u597d\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e2d\u3067\u3082\u3001Lactobacillus\uff08\u30e9\u30af\u30c8\u30d0\u30c1\u30eb\u30b9\u5c5e\uff09\u3084Bifidobacterium\uff08\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\uff09\u306e\u88dc\u5145\u306f\u3001\u5c0f\u898f\u6a21\u306a\u7814\u7a76\u306a\u304c\u3089\u4e00\u5b9a\u306e\u6539\u5584\u52b9\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u52a0\u3048\u3066\u3001\u3053\u3046\u3057\u305f\u8178\u2013\u8133\u8ef8\u306e\u95a2\u4fc2\u306f\u3001\u598a\u5a20\u4e2d\u306e\u6bcd\u4f53\u306e\u8178\u5185\u74b0\u5883\u3068\u80ce\u5150\u306e\u795e\u7d4c\u767a\u9054\u306b\u3082\u6df1\u304f\u95a2\u308f\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u598a\u5a20\u4e2d\u306e\u30b9\u30c8\u30ec\u30b9\u3084\u6804\u990a\u306e\u504f\u308a\u304c\u6bcd\u4f53\u306e\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u4e71\u3059\u3068\u3001\u305d\u308c\u304c\u80ce\u5150\u306e\u8178\u5185\u5b9a\u7740\uff08microbial colonization\uff09\u3084\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u5f62\u6210\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u6700\u7d42\u7684\u306b\u8133\u306e\u767a\u9054\u30d7\u30ed\u30bb\u30b9\u306b\u3082\u5909\u5316\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u6bcd\u4f53\u306e\u8178\u5185\u74b0\u5883\u306e\u60aa\u5316\u306b\u3088\u3063\u3066\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-6\u3001MCP-1\u306a\u3069\uff09\u306e\u5206\u6ccc\u304c\u9ad8\u307e\u308a\u3001\u3053\u308c\u304c\u80ce\u5150\u306e\u795e\u7d4c\u767a\u9054\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u3001\u52d5\u7269\u5b9f\u9a13\u306a\u3069\u3067\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u8fd1\u5e74\u3067\u306f\u3001\u98df\u7269\u6dfb\u52a0\u7269\uff08emulsifiers\u306a\u3069\uff09\u306e\u6442\u53d6\u3084\u3001\u98df\u7269\u7e4a\u7dad\u306e\u4e0d\u8db3\u3068\u3044\u3063\u305f\u98df\u751f\u6d3b\u306e\u5909\u5316\u304c\u3001\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027\u3084\u4ee3\u8b1d\u7523\u7269\u306e\u751f\u6210\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3001\u305d\u308c\u304c\u795e\u7d4c\u767a\u9054\u3084\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u8abf\u7bc0\uff08\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u5909\u5316\uff09\u306b\u307e\u3067\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u5831\u544a\u3082\u51fa\u3066\u304d\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u3046\u3057\u305f\u8178\u5185\u7d30\u83cc\u3068\u795e\u7d4c\u767a\u9054\u306e\u8907\u96d1\u306a\u95a2\u4fc2\u6027\u306f\u3001\u307e\u3060\u7814\u7a76\u306e\u9014\u4e0a\u306b\u3042\u308a\u307e\u3059\u304c\u3001\u300c\u8178\u306e\u5065\u5eb7\u3092\u6574\u3048\u308b\u3053\u3068\u304c\u3001\u5fc3\u3084\u884c\u52d5\u306e\u5065\u5eb7\u306b\u3064\u306a\u304c\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u300d\u3068\u3044\u3046\u8996\u70b9\u306f\u3001\u4eca\u5f8c\u306eASD\u7406\u89e3\u3068\u652f\u63f4\u306e\u5728\u308a\u65b9\u306b\u304a\u3044\u3066\u3001\u6975\u3081\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u98df\u4e8b\u3084\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306a\u3069\u3001\u6bd4\u8f03\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u3057\u3084\u3059\u3044\u624b\u6bb5\u3067\u8178\u5185\u74b0\u5883\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u3001ASD\u306e\u7ba1\u7406\uff08management\uff09\u3084\u4e88\u9632\uff08prevention\uff09\u306b\u304a\u3051\u308b\u4e00\u52a9\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3001\u4eca\u307e\u3055\u306b\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E4%BA%88%E5%BE%8C%EF%BD%9CPrognosis\"><\/span><strong>\u4e88\u5f8c\uff5cPrognosis<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/autism-spectrum-disorder-genetics\/\">\u81ea\u9589\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u75c7<\/a>\uff08ASD\uff09\u306e\u7d4c\u904e\u3084\u5c06\u6765\u306e\u898b\u901a\u3057\uff08\u4e88\u5f8c\uff09\u306f\u3001\u975e\u5e38\u306b\u500b\u4eba\u5dee\u304c\u5927\u304d\u304f\u3001\u591a\u304f\u306e\u8981\u56e0\u306b\u3088\u3063\u3066\u5de6\u53f3\u3055\u308c\u307e\u3059\u3002ASD\u306f\u4e00\u751f\u3092\u901a\u3058\u3066\u7d9a\u304f\u7279\u6027\u3092\u3082\u3064\u72b6\u614b\u3067\u3059\u304c\u3001\u9069\u5207\u306a\u652f\u63f4\u3084\u4ecb\u5165\u306b\u3088\u3063\u3066\u3001\u751f\u6d3b\u306e\u8cea\u3084\u81ea\u7acb\u5ea6\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u8981\u7d20\u304c\u4e88\u5f8c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\uff1a<\/p>\n\n\n\n<p>\u25cf ASD\u306e\u4e2d\u6838\u7684\u306a\u75c7\u72b6\u306e\u91cd\u3055\uff08\u793e\u4f1a\u7684\u306a\u56f0\u96e3\u3055\u3084\u53cd\u5fa9\u884c\u52d5\u306e\u7a0b\u5ea6\uff09<br>\u25cf \u8a8d\u77e5\u6a5f\u80fd\u306e\u6c34\u6e96\uff08\u77e5\u7684\u80fd\u529b\uff09<br>\u25cf \u3066\u3093\u304b\u3093\u3084\u6d88\u5316\u5668\u75c7\u72b6\u3001\u6ce8\u610f\u6b20\u5982\u30fb\u591a\u52d5\u75c7\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/adhd-genetics-symptoms-support\/\">ADHD<\/a>\uff09\u306a\u3069\u306e\u4f75\u5b58\u75c7\u306e\u6709\u7121<br>\u25cf \u5e7c\u5c11\u671f\u304b\u3089\u306e\u65e9\u671f\u4ecb\u5165\u3084\u7642\u80b2\u652f\u63f4\u306e\u5229\u7528\u72b6\u6cc1<\/p>\n\n\n\n<div style=\"height:24px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u307e\u305f\u3001\u8fd1\u5e74\u3067\u306f\u300c\u6804\u990a\u300d\u3068\u3044\u3046\u89b3\u70b9\u304b\u3089\u3082\u3001ASD\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3084\u75c7\u72b6\u306e\u7a0b\u5ea6\u304c\u5909\u308f\u308b\u53ef\u80fd\u6027\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305f\u3068\u3048\u3070\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u6804\u990a\u7684\u8981\u56e0\u306f\u3001ASD\u306e\u30ea\u30b9\u30af\u3092\u4e0b\u3052\u305f\u308a\u3001\u75c7\u72b6\u3092\u8efd\u304f\u3059\u308b\u65b9\u5411\u306b\u50cd\u304f\u3068\u3059\u308b\u7814\u7a76\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001\u9ad8\u8102\u80aa\u98df\u3084\u6804\u990a\u4e0d\u8db3\u3068\u3044\u3063\u305f\u6bcd\u4f53\u306e\u6804\u990a\u72b6\u614b\u306e\u4e71\u308c\u306f\u3001ASD\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u65b9\u5411\u306b\u50cd\u304f\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u7279\u306b\u3001\u3053\u3046\u3057\u305f\u5f71\u97ff\u306f\u300c\u8a3a\u65ad\u30ec\u30d9\u30eb\u306eASD\u300d\u305d\u306e\u3082\u306e\u3088\u308a\u3082\u3001ASD\u306b\u95a2\u9023\u3059\u308b\u7279\u6027\u3084\u50be\u5411\uff08\u305f\u3068\u3048\u3070\u793e\u4f1a\u7684\u306a\u5fdc\u7b54\u6027\u3084\u611f\u899a\u306e\u654f\u611f\u3055\u306a\u3069\uff09\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u52d5\u7269\u5b9f\u9a13\u306a\u3069\u3067\u306f\u3001\u6bcd\u4f53\u306e\u98df\u4e8b\u304c\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\uff08\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u8abf\u7bc0\u6a5f\u69cb\uff09\u3084\u30b7\u30ca\u30d7\u30b9\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u65b9\u3092\u5909\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u4eba\u306b\u304a\u3044\u3066\u3082\u5c06\u6765\u7684\u306b\u540c\u69d8\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u89e3\u660e\u3055\u308c\u3066\u3044\u304f\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B0%8F%E3%81%95%E3%81%AA%E7%A9%8D%E3%81%BF%E9%87%8D%E3%81%AD%E3%81%8C%E6%9C%AA%E6%9D%A5%E3%82%92%E3%81%A4%E3%81%8F%E3%82%8B\"><\/span><strong>\u5c0f\u3055\u306a\u7a4d\u307f\u91cd\u306d\u304c\u672a\u6765\u3092\u3064\u304f\u308b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u3053\u308c\u307e\u3067\u306b\u84c4\u7a4d\u3055\u308c\u3066\u304d\u305f\u591a\u304f\u306e\u89b3\u5bdf\u7814\u7a76\uff08observational studies\uff09\u3092\u898b\u3066\u307f\u308b\u3068\u3001\u4e00\u5b9a\u306e\u50be\u5411\u304c\u6d6e\u304b\u3073\u4e0a\u304c\u3063\u3066\u304d\u307e\u3059\u3002\u305d\u308c\u306f\u3001\u598a\u5a20\u521d\u671f\u3001\u3068\u304f\u306b\u53d7\u80ce\u524d\u5f8c\u304b\u3089\u598a\u5a20\u7b2c2\u671f\u306b\u304b\u3051\u3066\u3001\u8449\u9178\uff08folic acid\uff09\u3084\u30d3\u30bf\u30df\u30f3D\uff08vitamin D\uff09\u3001\u598a\u5a20\u7528\u30de\u30eb\u30c1\u30d3\u30bf\u30df\u30f3\uff08prenatal multivitamins\uff09\u306a\u3069\u3092\u9069\u5207\u306b\u6442\u53d6\u3057\u3066\u3044\u305f\u6bcd\u89aa\u304b\u3089\u751f\u307e\u308c\u305f\u5b50\u3069\u3082\u3067\u306f\u3001ASD\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u305f\u3068\u3044\u3046\u5831\u544a\u304c\u7e70\u308a\u8fd4\u3057\u306a\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff08omega-3 fatty acids\uff09\u3084\u3001\u708e\u75c7\u3092\u6291\u3048\u308b\u52b9\u679c\u304c\u3042\u308b\u3068\u3055\u308c\u308b\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u98df\u4e8b\u30b9\u30bf\u30a4\u30eb\uff08\u305f\u3068\u3048\u3070\u5730\u4e2d\u6d77\u5f0f\u98df\u4e8b\uff1aMediterranean diet\uff09\u3082\u3001\u80ce\u5150\u306e\u795e\u7d4c\u767a\u9054\u3092\u652f\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u3053\u3046\u3057\u305f\u7d50\u679c\u306b\u306f\u3070\u3089\u3064\u304d\u304c\u3042\u308a\u3001\u3059\u3079\u3066\u306e\u7814\u7a76\u3067\u4e00\u8cab\u3057\u3066\u540c\u3058\u7d50\u8ad6\u304c\u5c0e\u304b\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001\u6bcd\u4f53\u304c\u9ad8\u8102\u80aa\u98df\uff08high-fat diet\uff09\u3092\u7d99\u7d9a\u3057\u3066\u3044\u305f\u5834\u5408\u3084\u3001\u5fc5\u8981\u306a\u6804\u990a\u304c\u4e0d\u8db3\u3057\u3066\u3044\u305f\u5834\u5408\u306b\u306f\u3001\u708e\u75c7\u306e\u5897\u52a0\uff08inflammatory activation\uff09\u3084\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\uff08epigenetic modifications\uff1aDNA\u30e1\u30c1\u30eb\u5316\u306a\u3069\uff09\u3001\u795e\u7d4c\u4f1d\u9054\u7cfb\uff08neurotransmitter systems\uff09\u306e\u4e71\u308c\u3092\u901a\u3058\u3066\u3001ASD\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3082\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u6804\u990a\u3068ASD\u306e\u95a2\u4fc2\u6027\u306b\u95a2\u3059\u308b\u7814\u7a76\u306f\u7740\u5b9f\u306b\u5897\u3048\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u308c\u3067\u3082\u300c\u56e0\u679c\u95a2\u4fc2\u304c\u306f\u3063\u304d\u308a\u3057\u3066\u3044\u308b\u300d\u3068\u8a00\u3044\u5207\u308c\u308b\u6bb5\u968e\u306b\u306f\u307e\u3060\u81f3\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u60c5\u5831\u3092\u6b63\u3057\u304f\u53d7\u3051\u53d6\u308a\u3001\u5e0c\u671b\u3068\u73fe\u5b9f\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u4fdd\u3064\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%82%88%E3%81%8F%E8%A6%8B%E3%82%89%E3%82%8C%E3%82%8B%E7%A0%94%E7%A9%B6%E4%B8%8A%E3%81%AE%E9%99%90%E7%95%8C%EF%BC%88Common_Limitations%EF%BC%89%EF%BC%9A%E7%9F%A5%E3%82%8B%E3%81%93%E3%81%A8%E3%81%AE%E5%A4%A7%E5%88%87%E3%81%95%E3%80%81%E9%99%90%E7%95%8C%E3%82%92%E7%9F%A5%E3%82%8B%E3%81%93%E3%81%A8%E3%81%AE%E8%AC%99%E8%99%9A%E3%81%95\"><\/span><strong>\u3088\u304f\u898b\u3089\u308c\u308b\u7814\u7a76\u4e0a\u306e\u9650\u754c\uff08Common Limitations\uff09\uff1a\u77e5\u308b\u3053\u3068\u306e\u5927\u5207\u3055\u3001\u9650\u754c\u3092\u77e5\u308b\u3053\u3068\u306e\u8b19\u865a\u3055<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u73fe\u5728\u307e\u3067\u306b\u767a\u8868\u3055\u308c\u3066\u3044\u308b\u591a\u304f\u306e\u7814\u7a76\u306b\u306f\u3001\u3044\u304f\u3064\u304b\u5171\u901a\u3057\u305f\u9650\u754c\uff08limitations\uff09\u304c\u3042\u308a\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u598a\u5a20\u4e2d\u306e\u98df\u751f\u6d3b\u3092\u3042\u3068\u304b\u3089\u601d\u3044\u51fa\u3057\u3066\u7b54\u3048\u308b\u5f62\u5f0f\u306e\u300c\u56de\u9867\u7684\u8abf\u67fb\uff08retrospective studies\uff09\u300d\u3067\u306f\u3001\u8a18\u61b6\u306e\u504f\u308a\uff08recall bias\uff09\u306b\u3088\u3063\u3066\u30c7\u30fc\u30bf\u306e\u6b63\u78ba\u6027\u304c\u640d\u306a\u308f\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u6804\u990a\u72b6\u614b\u3092\u3069\u3046\u3084\u3063\u3066\u6e2c\u308b\u304b\u306b\u3082\u3055\u307e\u3056\u307e\u306a\u65b9\u6cd5\u304c\u3042\u308a\u3001\u98df\u4e8b\u8a18\u9332\uff08dietary questionnaires\uff09\u3001\u81ea\u5df1\u7533\u544a\uff08self-report\uff09\u3001\u8840\u6db2\u691c\u67fb\u306a\u3069\u3001\u305d\u308c\u305e\u308c\u306b\u9577\u6240\u3068\u77ed\u6240\u304c\u3042\u308a\u307e\u3059\u3002\u52a0\u3048\u3066\u3001\u3069\u306e\u6804\u990a\u7d20\u3092\u3069\u306e\u6642\u671f\u306b\u3069\u308c\u304f\u3089\u3044\u6442\u53d6\u3057\u305f\u304b\u304c\u4e00\u5b9a\u3067\u306f\u306a\u3044\u3053\u3068\u3082\u3001\u7d50\u679c\u306e\u3070\u3089\u3064\u304d\u306e\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u7814\u7a76\u306e\u5bfe\u8c61\u3068\u306a\u3063\u305f\u6bcd\u89aa\u3084\u5b50\u3069\u3082\u306e\u4eba\u6570\u304c\u5c11\u306a\u304b\u3063\u305f\u308a\u3001\u7279\u5b9a\u306e\u6804\u990a\u7d20\u3092\u6442\u53d6\u3057\u3066\u3044\u305f\u30b0\u30eb\u30fc\u30d7\u304c\u3054\u304f\u9650\u3089\u308c\u3066\u3044\u305f\u308a\u3059\u308b\u3068\u3001\u7d71\u8a08\u7684\u306b\u6709\u610f\u306a\u9055\u3044\u3092\u898b\u3064\u3051\u308b\u306e\u304c\u96e3\u3057\u304f\u306a\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u6bcd\u89aa\u306e\u6559\u80b2\u6b74\u3084\u7d4c\u6e08\u72b6\u6cc1\u3001\u751f\u6d3b\u7fd2\u6163\u3068\u3044\u3063\u305f\u300c\u4ea4\u7d61\u56e0\u5b50\uff08confounding factors\uff09\u300d\u304c\u5b8c\u5168\u306b\u306f\u8abf\u6574\u3055\u308c\u3066\u3044\u306a\u3044\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u3046\u3057\u305f\u70b9\u3092\u3075\u307e\u3048\u308b\u3068\u3001\u6804\u990a\u3068ASD\u3068\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u7406\u89e3\u3092\u6df1\u3081\u3066\u3044\u304f\u305f\u3081\u306b\u306f\u3001\u3088\u308a\u5927\u898f\u6a21\u3067\u7cbe\u5bc6\u306a\u7814\u7a76\u304c\u5fc5\u8981\u3068\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E4%BB%8A%E5%BE%8C%E3%81%AE%E7%A0%94%E7%A9%B6%E8%AA%B2%E9%A1%8C%EF%BC%88Future_Research_Priorities%EF%BC%89%EF%BC%9A%E3%81%93%E3%82%8C%E3%81%8B%E3%82%89%E3%81%AE%E5%B8%8C%E6%9C%9B%E3%82%92%E7%A7%91%E5%AD%A6%E3%81%AB%E3%81%A4%E3%81%AA%E3%81%90\"><\/span><strong>\u4eca\u5f8c\u306e\u7814\u7a76\u8ab2\u984c\uff08Future Research Priorities\uff09\uff1a\u3053\u308c\u304b\u3089\u306e\u5e0c\u671b\u3092\u79d1\u5b66\u306b\u3064\u306a\u3050<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u5c06\u6765\u306b\u5411\u3051\u3066\u3001ASD\u306e\u4e88\u9632\u3084\u75c7\u72b6\u306e\u8efd\u6e1b\u306b\u6804\u990a\u304c\u3069\u3046\u95a2\u308f\u3063\u3066\u3044\u308b\u306e\u304b\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u306b\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u91cd\u8981\u306a\u7814\u7a76\u8ab2\u984c\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305a\u306f\u3001\u300c\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\uff08randomized controlled trials\uff09\u300d\u306e\u5b9f\u65bd\u3067\u3059\u3002\u3053\u308c\u306f\u3001\u6804\u990a\u4ecb\u5165\u304c\u672c\u5f53\u306b\u52b9\u679c\u3092\u6301\u3064\u306e\u304b\u3092\u3001\u79d1\u5b66\u7684\u306b\u3082\u3063\u3068\u3082\u78ba\u5b9f\u306a\u65b9\u6cd5\u3067\u691c\u8a3c\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u307e\u305f\u3001\u598a\u5a20\u4e2d\u3084\u4e73\u5e7c\u5150\u671f\u3092\u901a\u3057\u3066\u3001\u8907\u6570\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3067\u6804\u990a\u72b6\u614b\u3092\u6e2c\u5b9a\u3057\u3001\u305d\u308c\u304c\u9577\u671f\u7684\u306a\u795e\u7d4c\u767a\u9054\u306b\u3069\u3046\u5f71\u97ff\u3059\u308b\u304b\u3092\u8abf\u3079\u308b\u300c\u7e26\u65ad\u7684\u30b3\u30db\u30fc\u30c8\u7814\u7a76\uff08longitudinal cohort studies\uff09\u300d\u3082\u975e\u5e38\u306b\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u4e00\u70ad\u7d20\u4ee3\u8b1d\u7d4c\u8def\uff08one-carbon 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https:\/\/doi.org\/10.1080\/1028415X.2018.1464819.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1002\/aur.2402\">Zhong, Caichen, et al. \u2018Maternal Dietary Factors and the Risk of Autism Spectrum Disorders: A Systematic Review of Existing Evidence\u2019. <em>Autism Research<\/em>, vol. 13, no. 10, Oct. 2020, pp. 1634\u201358. <em>DOI.org (Crossref)<\/em>, https:\/\/doi.org\/10.1002\/aur.2402.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/nu14132729\">Vecchione, Rachel, et al. \u2018Maternal Dietary Patterns during Pregnancy and Child Autism-Related Traits: Results from Two US Cohorts\u2019. Nutrients, vol. 14, no. 13, Jun. 2022, p. 2729. DOI.org (Crossref), https:\/\/doi.org\/10.3390\/nu14132729.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/nu16223802\">Vecchione, Rachel, et al. \u2018Maternal Dietary Patterns During Pregnancy and Child Autism-Related Traits in the Environmental Influences on Child Health Outcomes Consortium\u2019. Nutrients, vol. 16, no. 22, Nov. 2024, p. 3802. DOI.org (Crossref), https:\/\/doi.org\/10.3390\/nu16223802.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/nu13093212\">Gawli\u0144ska, Kinga, et al. \u2018A Maternal High-Fat Diet during Early Development Provokes Molecular Changes Related to Autism Spectrum Disorder in the Rat Offspring Brain\u2019. Nutrients, vol. 13, no. 9, Sep. 2021, p. 3212. 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