{"id":111413,"date":"2024-06-30T10:26:41","date_gmt":"2024-06-30T01:26:41","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-paxgene-blood-ccfdna-tube\/"},"modified":"2025-08-21T17:21:31","modified_gmt":"2025-08-21T08:21:31","slug":"about-paxgene-blood-ccfdna-tube","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-paxgene-blood-ccfdna-tube\/?lang=en","title":{"rendered":"PAXgene Blood ccfDNA Tube"},"content":{"rendered":"\n<div style=\"border:solid #ffe6e6 0.8rem;background-color: #fff9f9;padding:3% 5%;margin:1rem 0 3rem;\"><h2 style=\"margin-top:1rem;\">\u3053\u306e\u8a18\u4e8b\u306e\u307e\u3068\u3081<\/h2><p>The PAXgene Blood ccfDNA Tube is a tube specifically designed for the preservation and stabilization of circulating cell-free DNA (ccfDNA) in blood. This product has the following features:<\/p><\/div>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-paxgene-blood-ccfdna-tube\/?lang=en\/#High-quality_preservation_of_ccfDNA\" >High-quality preservation of ccfDNA<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-paxgene-blood-ccfdna-tube\/?lang=en\/#Non-invasive_sample_collectio\" >Non-invasive sample collectio<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-paxgene-blood-ccfdna-tube\/?lang=en\/#Enhanced_reliability_in_analysis\" >Enhanced reliability in analysis<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-paxgene-blood-ccfdna-tube\/?lang=en\/#Primary_applications\" >Primary applications<\/a><\/li><\/ul><\/nav><\/div>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"High-quality_preservation_of_ccfDNA\"><\/span><strong>High-quality preservation of ccfDNA<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>The <strong>PAXgene Blood ccfDNA Tube<\/strong> stabilizes <strong>circulating cell-free DNA (ccfDNA)<\/strong> immediately after blood collection, allowing samples to maintain high quality over an extended period. This stability prevents DNA degradation and ensures the accuracy and consistency of downstream analyses.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Non-invasive_sample_collectio\"><\/span><strong>Non-invasive sample collectio<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>This method is simple, convenient, and places minimal burden on the patient. Compared with traditional invasive sampling methods, obtaining ccfDNA through a blood draw is safer and more acceptable, making it particularly suitable for repeated sampling or long-term monitoring.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Enhanced_reliability_in_analysis\"><\/span><strong>Enhanced reliability in analysis<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Blood samples preserved in this tube provide significantly <strong>improved reliability and reproducibility<\/strong> when performing <strong>ccfDNA analysis<\/strong>, which is critical for various molecular diagnostic techniques such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Next-Generation Sequencing (NGS)<\/strong><strong><br><\/strong><\/li>\n\n\n\n<li><strong>Polymerase Chain Reaction (PCR)<\/strong><strong><br><\/strong><\/li>\n<\/ul>\n\n\n\n<p>By maintaining sample integrity, the tube reduces technical variation, resulting in more accurate test results and more dependable data for clinical and research applications.<\/p>\n\n\n\n    <a href=\"\/nipt\/difference-between-ccfdna-tube-and-dna-bct\/\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">PAXgene Blood ccfDNA Tube\u3068Streck Cell-Free DNA BCT\u306e\u9055\u3044 <\/div>\n          <div class=\"blog-card-excerpt\">...<\/div>\n      <\/div>\n    <\/a>\n\n\n\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"426\" src=\"\/nipt\/wp-content\/uploads\/2024\/12\/2743915_s.jpg\" alt=\"\u8d64\u3044\u6db2\u4f53\u3001\u30d4\u30da\u30c3\u30c8\u30c1\u30c3\u30d7\" class=\"wp-image-86649\"\/><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Primary_applications\"><\/span><strong>Primary applications<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>The PAXgene Blood ccfDNA Tube is widely used in both clinical and research settings, including:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Liquid biopsy for cancer<\/strong><strong><br><\/strong> Detection and monitoring of tumor DNA to enable non-invasive diagnosis and treatment assessment.<br><\/li>\n\n\n\n<li><strong>Prenatal diagnostics<\/strong><strong><br><\/strong> Detection of fetal DNA from maternal blood for non-invasive prenatal testing (<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>) or other genetic analyses.<br><\/li>\n\n\n\n<li><strong>Post-transplant monitoring<\/strong><strong><br><\/strong> Monitoring circulating DNA in transplant patients to help detect <strong>graft-versus-host disease (GVHD)<\/strong> or to evaluate transplant outcomes.<\/li>\n<\/ul>\n\n\n\n\n\n\n<p><strong>Intended users<\/strong><\/p>\n\n\n\n<p>This product is primarily designed for <strong>researchers<\/strong> and <strong>healthcare professionals<\/strong> who require high-quality, reliable data from blood samples to support precision diagnostics, disease research, and the advancement of personalized medicine.<\/p>\n\n\n\n    <a href=\"\/nipt\/about-the-accuracy-of-prenatal-paternity-testing\/\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">MiSeq FGx System\u3092\u7528\u3044\u305f\u51fa\u751f\u524d\u89aa\u5b50\u9451\u5b9a\u306e\u7cbe\u5ea6\u306b\u3064\u3044\u3066 <\/div>\n          <div class=\"blog-card-excerpt\">...<\/div>\n      <\/div>\n    <\/a>\n","protected":false},"excerpt":{"rendered":"\u3053\u306e\u8a18\u4e8b\u306e\u307e\u3068\u3081The PAXgene &#8230;\n <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-paxgene-blood-ccfdna-tube\/?lang=en\">\u7d9a\u304d\u3092\u8aad\u3080<\/a>","protected":false},"author":59,"featured_media":79904,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[97],"tags":[],"class_list":["post-111413","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/111413","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/comments?post=111413"}],"version-history":[{"count":2,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/111413\/revisions"}],"predecessor-version":[{"id":111429,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/111413\/revisions\/111429"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media\/79904"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=111413"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/categories?post=111413"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/tags?post=111413"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}