{"id":111866,"date":"2024-11-14T13:10:50","date_gmt":"2024-11-14T04:10:50","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/jacobsen\/"},"modified":"2025-08-22T14:54:39","modified_gmt":"2025-08-22T05:54:39","slug":"jacobsen","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/jacobsen\/?lang=zh-hans","title":{"rendered":"\u96c5\u5404\u5e03\u68ee\u7efc\u5408\u5f81"},"content":{"rendered":"\n<div style=\"border:solid #ffe6e6 0.8rem;background-color: #fff9f9;padding:3% 5%;margin:1rem 0 3rem;\"><h2 style=\"margin-top:1rem;\">\u3053\u306e\u8a18\u4e8b\u306e\u307e\u3068\u3081<\/h2><p>\u30e4\u30b3\u30d6\u30bb\u30f3\u75c7\u5019\u7fa4\u306f\u3001\u7279\u5fb4\u7684\u306a\u9854\u7acb\u3061\u3084\u5148\u5929\u6027\u5fc3\u75be\u60a3\u3001\u51fa\u8840\u6027\u75be\u60a3\u3001<a 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href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/jacobsen\/?lang=zh-hans\/#%E7%96%BE%E6%82%A3%E6%A6%82%E8%A6%81\" >\u75be\u60a3\u6982\u8981<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/jacobsen\/?lang=zh-hans\/#%E7%97%85%E5%9B%A0%E4%B8%8E%E8%AF%8A%E6%96%AD%E6%96%B9%E6%B3%95\" >\u75c5\u56e0\u4e0e\u8bca\u65ad\u65b9\u6cd5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/jacobsen\/?lang=zh-hans\/#%E7%96%BE%E7%97%85%E7%9A%84%E7%97%87%E7%8A%B6%E4%B8%8E%E7%AE%A1%E7%90%86%E6%96%B9%E6%B3%95\" >\u75be\u75c5\u7684\u75c7\u72b6\u4e0e\u7ba1\u7406\u65b9\u6cd5<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/jacobsen\/?lang=zh-hans\/#%E7%89%B9%E5%BE%81%E6%80%A7%E9%9D%A2%E5%AE%B9\" 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href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/jacobsen\/?lang=zh-hans\/#%E9%A2%9D%E5%A4%96%E7%9A%84%E5%8C%BB%E7%96%97%E9%97%AE%E9%A2%98%E4%B8%8E%E7%AE%A1%E7%90%86%E6%96%B9%E6%B3%95\" >\u989d\u5916\u7684\u533b\u7597\u95ee\u9898\u4e0e\u7ba1\u7406\u65b9\u6cd5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/jacobsen\/?lang=zh-hans\/#%E6%9C%AA%E6%9D%A5%E5%B1%95%E6%9C%9B%EF%BC%88%E9%A2%84%E5%90%8E%EF%BC%89\" >\u672a\u6765\u5c55\u671b\uff08\u9884\u540e\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/jacobsen\/?lang=zh-hans\/#%E5%BC%95%E7%94%A8%E6%96%87%E7%8C%AE\" >\u5f15\u7528\u6587\u732e<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%96%BE%E6%82%A3%E6%A6%82%E8%A6%81\"><\/span>\u75be\u60a3\u6982\u8981<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"23\" src=\"\/nipt\/wp-content\/uploads\/2024\/11\/chr11q23.3-q25-hgtIdeo_genome_ea131_238cd0-1024x23.png\" alt=\"chr11q23.3-q25\" class=\"wp-image-88788\"\/><\/figure><\/div>\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>\u96c5\u5404\u5e03\u68ee\u7efc\u5408\u5f81\uff08Jacobsen\u7efc\u5408\u5f81\uff0cJS\uff09<\/strong> \u6700\u65e9\u7531 Jacobsen \u4e8e 1973 \u5e74\u9996\u6b21\u62a5\u9053\u3002\u636e\u7edf\u8ba1\uff0c\u7ea6 85% \u7684\u75c5\u4f8b\u5c5e\u4e8e\u81ea\u7136\u53d1\u751f\uff08de novo\uff09\u3002\u5176\u53d1\u75c5\u7387\u4f30\u8ba1\u4e3a\u6bcf 5 \u4e07\u81f3 10 \u4e07\u65b0\u751f\u513f\u4e2d\u6709 1 \u4f8b\uff0c\u4e14\u5973\u6027\u60a3\u8005\u591a\u4e8e\u7537\u6027\uff08\u7ea6\u5360 70%\uff09\uff0c\u663e\u793a\u5973\u6027\u7684\u53d1\u75c5\u7387\u66f4\u9ad8\u3002<\/p>\n\n\n\n<p>\u96c5\u5404\u5e03\u68ee\u7efc\u5408\u5f81\u7684\u4e34\u5e8a\u8868\u73b0\u56e0\u4e2a\u4f53\u5dee\u5f02\u800c\u6709\u5f88\u5927\u4e0d\u540c\u3002\u7f3a\u5931\u7684\u8303\u56f4\u548c\u4f4d\u7f6e\u4f1a\u5f71\u54cd\u75c7\u72b6\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u4f46\u4e00\u4e9b\u7279\u5f81\u6027\u7684\u75c7\u72b6\u5728\u5927\u591a\u6570\u60a3\u8005\u4e2d\u8f83\u4e3a\u5e38\u89c1\uff0c\u5305\u62ec\uff1a\u51fa\u751f\u524d\u53ca\u51fa\u751f\u540e\u7684\u751f\u957f\u8fdf\u7f13\u3001\u667a\u529b\u969c\u788d\u548c\u7cbe\u795e\u8fd0\u52a8\u53d1\u80b2\u8fdf\u7f13\u3002\u6b64\u5916\uff0c\u5bbd\u9614\u7684\u9f3b\u6881\u3001\u4e0b\u5782\u7684\u53e3\u89d2\u3001\u5c0f\u4e0b\u988c\u7b49\u5178\u578b\u7684\u9762\u5bb9\u7279\u5f81\u4e5f\u6709\u52a9\u4e8e\u4e34\u5e8a\u8bca\u65ad\u3002<\/p>\n\n\n\n<p>\u96c5\u5404\u5e03\u68ee\u7efc\u5408\u5f81\u7684\u4e00\u4e2a\u5178\u578b\u7279\u5f81\u662f\u79f0\u4e3a <strong>\u201cParis-Trousseau \u7efc\u5408\u5f81\u201d<\/strong> \u7684\u51fa\u8840\u6027\u75be\u75c5\u3002\u7814\u7a76\u8868\u660e\uff0c\u7ea6 88.5% \u7684\u60a3\u8005\u8868\u73b0\u51fa\u8be5\u75c7\u72b6\uff0c\u5e76\u4ece\u51fa\u751f\u8d77\u5c31\u5b58\u5728 <strong>\u8840\u5c0f\u677f\u51cf\u5c11\u75c7<\/strong>\uff08\u8840\u5c0f\u677f\u6570\u91cf\u4f4e\uff09\u3002\u8840\u5c0f\u677f\u51cf\u5c11\u6709\u65f6\u4f34\u968f <strong>\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u75c7<\/strong>\uff08\u6dcb\u5df4\u7ec6\u80de\u6570\u91cf\u4f4e\uff09\uff0c\u63d0\u793a\u53ef\u80fd\u5b58\u5728\u514d\u75ab\u7f3a\u9677\u3002\u56e0\u6b64\uff0c\u60a3\u8005\u66f4\u5bb9\u6613\u611f\u67d3\uff0c\u4e14\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u53ef\u80fd\u4e0e <strong>\u590d\u5408\u578b\u514d\u75ab\u7f3a\u9677\u7efc\u5408\u5f81<\/strong> \u6709\u5173\u3002<\/p>\n\n\n\n<p>\u6b64\u5916\uff0c\u96c5\u5404\u5e03\u68ee\u7efc\u5408\u5f81\u60a3\u8005\u5e38\u4f34\u968f\u591a\u79cd\u533b\u7597\u5e76\u53d1\u75c7\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5148\u5929\u6027\u5fc3\u810f\u75c5<\/strong>\uff1a\u5982\u5ba4\u95f4\u9694\u7f3a\u635f\u3001\u80ba\u52a8\u8109\u74e3\u72ed\u7a84\u7b49\u3002<\/li>\n\n\n\n<li><strong>\u7ed3\u6784\u6027\u5f02\u5e38<\/strong>\uff1a\u6d89\u53ca\u80be\u810f\u3001\u6d88\u5316\u9053\u3001\u751f\u6b96\u5668\u548c\u9aa8\u9abc\u3002<\/li>\n\n\n\n<li><strong>\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u5f02\u5e38<\/strong>\uff1a\u90e8\u5206\u60a3\u8005\u53ef\u51fa\u73b0\u667a\u529b\u4f4e\u4e0b\u3001\u89c6\u529b\u4e0e\u542c\u529b\u969c\u788d\u4ee5\u53ca\u6fc0\u7d20\u5931\u8861\u3002<\/li>\n\n\n\n<li><strong>\u514d\u75ab\u7cfb\u7edf\u7f3a\u9677<\/strong>\uff1a\u4e0e\u4fb5\u88ad\u6027\u80bf\u7624\u7684\u53d1\u751f\u98ce\u9669\u589e\u52a0\u76f8\u5173\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u56e0\u6b64\uff0c\u96c5\u5404\u5e03\u68ee\u7efc\u5408\u5f81\u4e0d\u4ec5\u8868\u73b0\u4e3a\u53d1\u80b2\u8fdf\u7f13\u548c\u7279\u6b8a\u9762\u5bb9\uff0c\u8fd8\u53ef\u80fd\u4f34\u968f\u4e25\u91cd\u7684\u8840\u6db2\u5b66\u548c\u514d\u75ab\u5b66\u95ee\u9898\uff0c\u4ee5\u53ca\u591a\u7cfb\u7edf\u7684\u7ed3\u6784\u6027\u5f02\u5e38\u3002<\/p>\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/nipt\/wp-content\/uploads\/2024\/11\/31510744_s.jpg\" alt=\"\u7d46\u5275\u818f\" class=\"wp-image-88803\"\/><\/figure><\/div>\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%97%85%E5%9B%A0%E4%B8%8E%E8%AF%8A%E6%96%AD%E6%96%B9%E6%B3%95\"><\/span>\u75c5\u56e0\u4e0e\u8bca\u65ad\u65b9\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u96c5\u5404\u5e03\u68ee\u7efc\u5408\u5f81\u662f\u4e00\u79cd\u7531 <strong>\u7b2c11\u53f7\u67d3\u8272\u4f53\u957f\u81c2\uff0811q\uff09\u90e8\u5206\u7f3a\u5931<\/strong> \u5f15\u8d77\u7684\u9057\u4f20\u6027\u75be\u75c5\u3002\u5927\u591a\u6570\u7f3a\u5931\u5c5e\u4e8e\u6240\u8c13\u7684 <strong>\u201c\u672b\u7aef\u7f3a\u5931\u201d<\/strong>\uff0c\u5373\u7f3a\u5931\u4e00\u76f4\u5ef6\u4f38\u5230\u67d3\u8272\u4f53\u7684\u672b\u7aef\u3002<\/p>\n\n\n\n<p>\u7f3a\u5931\u7684\u5927\u5c0f\u901a\u5e38\u7ea6\u4e3a <strong>7\u301c16\u5146\u78b1\u57fa\uff08Mb\uff09<\/strong>\uff0c\u5176\u8d77\u59cb\u70b9\uff08\u8fd1\u7aef\u65ad\u88c2\u70b9\uff09\u4f4d\u4e8e <strong>11q23.3\u4e9a\u5e26\u5185\u6216\u5176\u5916\u4fa7<\/strong>\uff0c\u5e76\u5ef6\u4f38\u81f3\u67d3\u8272\u4f53\u7684\u672b\u7aef\uff08\u7aef\u7c92\uff09\u3002<\/p>\n\n\n\n<p>\u90e8\u5206\u75c5\u4f8b\u4e2d\uff0c\u7f3a\u5931\u5c0f\u4e8e <strong>7Mb<\/strong>\uff0c\u6216\u8868\u73b0\u4e3a\u8be5\u533a\u57df\u5185\u7684 <strong>\u4e2d\u95f4\u7f3a\u5931<\/strong>\uff0c\u8fd9\u7c7b\u60c5\u51b5\u88ab\u79f0\u4e3a <strong>\u201c\u90e8\u5206\u6027\u96c5\u5404\u5e03\u68ee\u7efc\u5408\u5f81\u201d<\/strong>\uff0c\u4e34\u5e8a\u8868\u73b0\u901a\u5e38\u8f83\u8f7b\u3002<\/p>\n\n\n\n<p>\u5728\u5c11\u6570\u60c5\u51b5\u4e0b\uff0c\u7f3a\u5931\u7684\u65ad\u88c2\u70b9\u4f4d\u4e8e <strong>FRA11B\u8106\u5f31\u4f4d\u70b9<\/strong>\uff0c\u8fd8\u53ef\u80fd\u51fa\u73b0 <strong>\u5d4c\u5408\u578b\uff08\u9a6c\u8d5b\u514b\u578b\uff09<\/strong>\uff0c\u5373\u53ea\u6709\u90e8\u5206\u7ec6\u80de\u5b58\u5728\u7f3a\u5931\u3002\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u60a3\u8005\u7684\u75c7\u72b6\u53ef\u80fd\u4f1a\u6709\u6240\u51cf\u8f7b\u3002<\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"512\" height=\"500\" src=\"\/nipt\/wp-content\/uploads\/2024\/11\/chr11-MdZEZEbIcZZMeCaKdUAAAHMX.png\" alt=\"chr11\" class=\"wp-image-88797\"\/><\/figure><\/div>\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n\n\n\n<p>\u96c5\u5404\u5e03\u68ee\u7efc\u5408\u5f81\u7684\u8bca\u65ad\u4e3b\u8981\u57fa\u4e8e <strong>\u7279\u5f81\u6027\u7684\u4e34\u5e8a\u8868\u73b0<\/strong>\uff0c\u5e76\u901a\u8fc7 <strong>\u9057\u4f20\u5b66\u68c0\u6d4b<\/strong> \u4e88\u4ee5\u786e\u8ba4\u3002<\/p>\n\n\n\n<p>\u5e38\u7528\u7684\u68c0\u6d4b\u65b9\u6cd5\u5305\u62ec\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u82af\u7247\u6bd4\u8f83\u57fa\u56e0\u7ec4\u6742\u4ea4\u6280\u672f\uff08array CGH\uff09<\/strong>\uff1a\u7528\u4e8e\u68c0\u6d4b\u67d3\u8272\u4f53\u7f3a\u5931\u7684\u4f4d\u7f6e\u548c\u8303\u56f4\u3002<\/li>\n\n\n\n<li><strong>\u8367\u5149\u539f\u4f4d\u6742\u4ea4\uff08FISH\uff09<\/strong>\uff1a\u53ef\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u7f3a\u5931\u533a\u57df\uff0c\u786e\u8ba4\u8bca\u65ad\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u5728 <strong>\u4ea7\u524d\u8bca\u65ad<\/strong> \u4e2d\uff0c\u53ef\u4ee5\u901a\u8fc7\u5bf9 <strong>\u7f8a\u6c34\u6216\u7ed2\u6bdb\u6837\u672c<\/strong> \u7684\u57fa\u56e0\u7ec4DNA\u8fdb\u884c array CGH \u5206\u6790\u6765\u53d1\u73b0\u7f3a\u5931\u3002\u6b64\u5916\uff0c\u68c0\u6d4b\u6bcd\u4f53\u8840\u6db2\u4e2d <strong>\u80ce\u513f\u6e38\u79bbDNA<\/strong> \u7684 <strong>\u65e0\u521b\u4ea7\u524d\u68c0\u6d4b\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>\uff09<\/strong> \u4e5f\u6709\u53ef\u80fd\u53d1\u73b0\u96c5\u5404\u5e03\u68ee\u7efc\u5408\u5f81\u7b49\u67d3\u8272\u4f53\u7f3a\u5931\u3002\u7136\u800c\uff0c<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> \u5bf9\u8be5\u75be\u75c5\u7684\u53ef\u9760\u6027\u5c1a\u672a\u5b8c\u5168\u786e\u7acb\u3002<\/p>\n\n\n\n<p>\u5927\u7ea6 <strong>90% \u7684\u96c5\u5404\u5e03\u68ee\u7efc\u5408\u5f81\u75c5\u4f8b<\/strong> \u5e76\u975e\u6765\u81ea\u7236\u6bcd\u9057\u4f20\uff0c\u800c\u662f <strong>\u81ea\u7136\u53d1\u751f\uff08de novo\uff09<\/strong>\u3002\u5176\u4f59\u75c5\u4f8b\u5219\u53ef\u80fd\u7531\u7236\u6bcd\u9057\u4f20\u800c\u6765\uff0c\u8fd9\u901a\u5e38\u53d1\u751f\u5728\u4ee5\u4e0b\u60c5\u51b5\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7236\u6bcd\u4e00\u65b9\u643a\u5e26 <strong>\u5e73\u8861\u578b\u67d3\u8272\u4f53\u6613\u4f4d<\/strong>\uff08\u53ef\u80fd\u5bfc\u81f4\u5b50\u4ee3\u51fa\u73b0\u4e0d\u5e73\u8861\u6613\u4f4d\uff09\uff1b<\/li>\n\n\n\n<li>\u6216\u7236\u6bcd\u4e00\u65b9\u81ea\u8eab\u5b58\u5728 <strong>11q\u672b\u7aef\u7f3a\u5931<\/strong>\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u968f\u7740 <strong>DNA\u6d4b\u5e8f\u6280\u672f<\/strong> \u548c <strong>\u65e0\u521b\u4ea7\u524d\u68c0\u6d4b<\/strong> \u7684\u4e0d\u65ad\u8fdb\u6b65\uff0c\u4eba\u4eec\u53ef\u4ee5\u66f4\u7cbe\u786e\u3001\u66f4\u53ef\u9760\u5730\u53d1\u73b0\u9057\u4f20\u5f02\u5e38\u3002\u8fd9\u4e9b\u65b9\u6cd5\u80fd\u591f\u5728\u4e0d\u635f\u5bb3\u6bcd\u4f53\u4e0e\u80ce\u513f\u5065\u5eb7\u7684\u524d\u63d0\u4e0b\uff0c\u4e3a\u5e0c\u671b\u65e9\u671f\u8bca\u65ad\u7684\u5bb6\u5ead\u63d0\u4f9b\u66f4\u5b89\u5168\u7684\u9009\u62e9\u3002<\/p>\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"426\" src=\"\/nipt\/wp-content\/uploads\/2024\/11\/31295073_s.jpg\" alt=\"\u304a\u3066\u3066\" class=\"wp-image-87378\"\/><\/figure><\/div>\n\n\n<div style=\"height:19px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%96%BE%E7%97%85%E7%9A%84%E7%97%87%E7%8A%B6%E4%B8%8E%E7%AE%A1%E7%90%86%E6%96%B9%E6%B3%95\"><\/span>\u75be\u75c5\u7684\u75c7\u72b6\u4e0e\u7ba1\u7406\u65b9\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>\u96c5\u5404\u5e03\u68ee\u7efc\u5408\u5f81\uff08Jacobsen\u7efc\u5408\u5f81\uff0cJS\uff09<\/strong> \u662f\u7531\u4e8e <strong>\u7b2c11\u53f7\u67d3\u8272\u4f53\u957f\u81c2\uff0811q\uff09\u90e8\u5206\u7f3a\u5931<\/strong> \u5f15\u8d77\u7684\u4e00\u79cd\u7f55\u89c1\u9057\u4f20\u6027\u75be\u75c5\u3002\u8be5\u75be\u75c5\u7684\u75c7\u72b6\u8303\u56f4\u5e7f\u6cdb\uff0c\u5176\u4e25\u91cd\u7a0b\u5ea6\u56e0\u7f3a\u5931\u7684\u5927\u5c0f\u548c\u4f4d\u7f6e\u800c\u5f02\u3002\u4e3b\u8981\u75c7\u72b6\u5305\u62ec\u9885\u9762\u90e8\u7578\u5f62\u3001\u5148\u5929\u6027\u5fc3\u810f\u75c5\u3001\u667a\u529b\u969c\u788d\u3001\u884c\u4e3a\u95ee\u9898\u4ee5\u53ca\u4e25\u91cd\u7684\u51fa\u8840\u6027\u75be\u75c5\u3002\u6b64\u5916\uff0c\u8bb8\u591a\u60a3\u8005\u8fd8\u8868\u73b0\u51fa\u80be\u810f\u4e0e\u6ccc\u5c3f\u751f\u6b96\u5668\u7684\u7ed3\u6784\u5f02\u5e38\u3001\u6162\u6027\u4fbf\u79d8\u4ee5\u53ca\u514d\u75ab\u7f3a\u9677\uff0c\u8fd9\u4e9b\u90fd\u589e\u52a0\u4e86\u75be\u75c5\u7ba1\u7406\u7684\u590d\u6742\u6027\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%89%B9%E5%BE%81%E6%80%A7%E9%9D%A2%E5%AE%B9\"><\/span>\u7279\u5f81\u6027\u9762\u5bb9<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>JS \u60a3\u8005\u5177\u6709\u4e00\u4e9b\u5178\u578b\u7684\u9762\u90e8\u7279\u5f81\uff0c\u5305\u62ec\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u9885\u9aa8\u7578\u5f62<\/li>\n\n\n\n<li>\u773c\u8ddd\u5bbd\uff08\u8fdc\u4f4d\u773c\u8ddd\u8fc7\u5bbd\uff09<\/li>\n\n\n\n<li>\u4e0a\u7751\u4e0b\u5782<\/li>\n\n\n\n<li>\u773c\u7ec4\u7ec7\u7f3a\u635f\uff08\u5982\u8109\u7edc\u819c\u88c2\uff09<\/li>\n\n\n\n<li>\u773c\u88c2\u4e0b\u659c<\/li>\n\n\n\n<li>\u5185\u7726\u8d58\u76ae<\/li>\n\n\n\n<li>\u5bbd\u9f3b\u6881\u3001\u77ed\u9f3b<\/li>\n\n\n\n<li>V\u5b57\u578b\u53e3<\/li>\n\n\n\n<li>\u5c0f\u800c\u4f4e\u4f4d\u3001\u5411\u540e\u7684\u8033\u6735<\/li>\n<\/ul>\n\n\n\n<p>\u90e8\u5206\u60a3\u8005\u8fd8\u4f1a\u51fa\u73b0\u9885\u7f1d\u65e9\u95ed\uff0c\u8fd9\u53ef\u80fd\u9700\u8981\u65e9\u671f\u7684\u5916\u79d1\u5e72\u9884\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%87%BA%E8%A1%80%E6%80%A7%E7%96%BE%E7%97%85\"><\/span>\u51fa\u8840\u6027\u75be\u75c5<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>JS \u7684\u4e00\u4e2a\u4ee3\u8868\u6027\u75c7\u72b6\u662f\u79f0\u4e3a\u201cParis-Trousseau \u7efc\u5408\u5f81\u201d\u7684\u51fa\u8840\u6027\u75be\u75c5\uff0c\u7ea688.5%\u7684\u60a3\u8005\u6709\u6b64\u8868\u73b0\u3002\u5176\u7279\u70b9\u662f\u51fa\u751f\u65f6\u5373\u5b58\u5728\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3002\u968f\u7740\u6210\u957f\uff0c\u8840\u5c0f\u677f\u6570\u91cf\u53ef\u80fd\u589e\u52a0\uff0c\u4f46\u8840\u5c0f\u677f\u7684\u529f\u80fd\u5f02\u5e38\u4f1a\u7ec8\u8eab\u5b58\u5728\uff0c\u5bfc\u81f4\u6301\u7eed\u7684\u51fa\u8840\u98ce\u9669\u3002<\/p>\n\n\n\n<p>\u60a3\u8005\u5e38\u89c1\u8868\u73b0\u5305\u62ec\u5bb9\u6613\u6de4\u9752\u3001\u5c0f\u4f24\u53e3\u51fa\u8840\u4e0d\u6b62\uff0c\u4ee5\u53ca\u5185\u51fa\u8840\u7684\u98ce\u9669\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7ba1\u7406\u65b9\u6cd5\uff1a\u9700\u8981\u5b9a\u671f\u8fdb\u884c\u51dd\u8840\u68c0\u67e5\u3002<\/li>\n\n\n\n<li>\u624b\u672f\u524d\u540e\u53ca\u91cd\u75c7\u60a3\u8005\u53ef\u80fd\u9700\u8981\u8840\u5c0f\u677f\u8f93\u6ce8\u3002<\/li>\n\n\n\n<li>\u5e94\u907f\u514d\u4f7f\u7528\u5f71\u54cd\u8840\u5c0f\u677f\u529f\u80fd\u7684\u836f\u7269\uff08\u5982\u5e03\u6d1b\u82ac\uff09\u3002<\/li>\n\n\n\n<li>\u53bb\u6c28\u52a0\u538b\u7d20\uff08DDAVP\uff09\u9f3b\u55b7\u5242\u53ef\u7528\u4e8e\u6025\u6027\u51fa\u8840\u7684\u5904\u7406\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%BF%83%E8%84%8F%E4%B8%8E%E5%8F%91%E8%82%B2%E9%97%AE%E9%A2%98\"><\/span>\u5fc3\u810f\u4e0e\u53d1\u80b2\u95ee\u9898<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u8bb8\u591a JS \u60a3\u8005\u4f34\u6709\u4e25\u91cd\u7684\u5fc3\u810f\u7578\u5f62\uff08\u5982\u5ba4\u95f4\u9694\u7f3a\u635f\uff09\uff0c\u5e38\u9700\u5728\u65b0\u751f\u513f\u671f\u624b\u672f\u3002\u8fd9\u7c7b\u5fc3\u810f\u75be\u75c5\u662f\u4e24\u5c81\u4ee5\u5185\u5e76\u53d1\u75c7\u4e0e\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002<\/p>\n\n\n\n<p>\u5927\u591a\u6570\u60a3\u8005\u6709\u8f7b\u5ea6\u5230\u91cd\u5ea6\u7684\u667a\u529b\u969c\u788d\uff0c\u5e76\u4f34\u968f\u7cbe\u795e\u8fd0\u52a8\u53d1\u80b2\u8fdf\u7f13\u3002\u5e38\u89c1\u7684\u884c\u4e3a\u95ee\u9898\u5305\u62ec\u591a\u52a8\u75c7\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/adhd-genetics-symptoms-support\/\">ADHD<\/a>\uff09\u3001\u81ea\u95ed\u75c7\u8c31\u7cfb\u7279\u5f81\u4ee5\u53ca\u60c5\u7eea\u95ee\u9898\uff0c\u56e0\u6b64\u9700\u8981\u53d1\u80b2\u4e13\u5bb6\u4e0e\u5eb7\u590d\u6cbb\u7597\u5e08\u7684\u652f\u6301\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%94%9F%E9%95%BF%E4%B8%8E%E5%85%8D%E7%96%AB\"><\/span>\u751f\u957f\u4e0e\u514d\u75ab<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u65b0\u751f\u513f\u671f\u5e38\u6709\u5582\u517b\u56f0\u96be\uff0c\u53ef\u80fd\u9700\u8981\u7ba1\u9972\u8425\u517b\u3002\u751f\u957f\u8fdf\u7f13\u5e38\u89c1\uff0c\u8bb8\u591a\u60a3\u513f\u7531\u4e8e\u751f\u957f\u6fc0\u7d20\u7f3a\u4e4f\u800c\u8868\u73b0\u4e3a\u8eab\u6750\u77ee\u5c0f\u3002\u867d\u7136\u751f\u957f\u6fc0\u7d20\u6cbb\u7597\u662f\u4e00\u79cd\u9009\u62e9\uff0c\u4f46\u7531\u4e8e JS \u60a3\u8005\u53ef\u80fd\u5b58\u5728\u80bf\u7624\u98ce\u9669\u589e\u52a0\uff0c\u9700\u8c28\u614e\u8003\u8651\u3002<\/p>\n\n\n\n<p>\u514d\u75ab\u7f3a\u9677\u4f7f\u60a3\u513f\u5728\u5e7c\u5e74\u671f\u5bb9\u6613\u53cd\u590d\u611f\u67d3\u3002\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u75c7\uff08\u6dcb\u5df4\u7ec6\u80de\u6570\u91cf\u4f4e\uff09\u4e5f\u52a0\u91cd\u4e86\u611f\u67d3\u6613\u611f\u6027\u3002<\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"426\" src=\"\/nipt\/wp-content\/uploads\/2024\/11\/31048631_s-1.jpg\" alt=\"\u3053\u3069\u3082\u306e\u8a3a\u65ad\" class=\"wp-image-88820\"\/><\/figure><\/div>\n\n\n<div style=\"height:13px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%A2%9D%E5%A4%96%E7%9A%84%E5%8C%BB%E7%96%97%E9%97%AE%E9%A2%98%E4%B8%8E%E7%AE%A1%E7%90%86%E6%96%B9%E6%B3%95\"><\/span>\u989d\u5916\u7684\u533b\u7597\u95ee\u9898\u4e0e\u7ba1\u7406\u65b9\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u96c5\u5404\u5e03\u68ee\u7efc\u5408\u5f81\u60a3\u8005\u53ef\u80fd\u8fd8\u4f1a\u9762\u4e34\u4ee5\u4e0b\u989d\u5916\u7684\u533b\u7597\u95ee\u9898\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u80be\u810f\u548c\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7edf\u5f02\u5e38<\/strong>\uff08\u5982\u7537\u6027\u7684\u9690\u777e\u75c7\uff09<\/li>\n\n\n\n<li><strong>\u6d88\u5316\u7cfb\u7edf\u95ee\u9898<\/strong>\uff08\u5982\u5e7d\u95e8\u72ed\u7a84\u6216\u6162\u6027\u4fbf\u79d8\uff09<\/li>\n\n\n\n<li><strong>\u773c\u90e8\u5f02\u5e38<\/strong>\uff08\u5982\u659c\u89c6\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u672a\u6cbb\u7597\u7684\u659c\u89c6\u53ef\u80fd\u5bfc\u81f4\u5f31\u89c6\uff0c\u56e0\u6b64\u9700\u8981\u65e9\u671f\u624b\u672f\u5e72\u9884\u3002\u90e8\u5206\u60a3\u8005\u8fd8\u4f1a\u51fa\u73b0 <strong>\u7532\u72b6\u817a\u6fc0\u7d20\u7f3a\u4e4f\u75c7<\/strong>\uff0c\u9700\u8981\u8fdb\u884c <strong>\u6fc0\u7d20\u66ff\u4ee3\u6cbb\u7597<\/strong>\u3002<\/p>\n\n\n\n<p>\u96c5\u5404\u5e03\u68ee\u7efc\u5408\u5f81\u7684\u7ba1\u7406\u6d89\u53ca\u591a\u4e2a\u533b\u5b66\u9886\u57df\uff0c\u9700\u8981\u6839\u636e\u6bcf\u4f4d\u60a3\u8005\u7684\u9700\u6c42\u63d0\u4f9b\u7efc\u5408\u6027\u7167\u62a4\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u51fa\u8840\u98ce\u9669\u7ba1\u7406\uff1a\u9700\u8981\u5b9a\u671f\u76d1\u6d4b\u8840\u5c0f\u677f\u529f\u80fd\uff1b\u5728\u624b\u672f\u524d\uff0c\u5efa\u8bae\u8fdb\u884c\u9884\u9632\u6027\u7684\u8840\u5c0f\u677f\u6216\u5168\u8840\u8f93\u6ce8\u3002<\/li>\n\n\n\n<li>\u5eb7\u590d\u5e72\u9884\uff1a\u8bed\u8a00\u6cbb\u7597\u3001\u7269\u7406\u6cbb\u7597\u3001\u4f5c\u4e1a\u6cbb\u7597\u548c\u884c\u4e3a\u6cbb\u7597\u7b49\u7efc\u5408\u9879\u76ee\u6709\u52a9\u4e8e\u63d0\u9ad8\u60a3\u8005\u7684\u8ba4\u77e5\u548c\u8fd0\u52a8\u6280\u80fd\u3002<\/li>\n\n\n\n<li>\u5fc3\u810f\u95ee\u9898\uff1a\u90e8\u5206\u60a3\u8005\u53ef\u80fd\u9700\u8981\u65e9\u671f\u7684\u5916\u79d1\u624b\u672f\u3002<\/li>\n\n\n\n<li>\u9aa8\u79d1\u95ee\u9898\uff1a\u5982\u9885\u9aa8\u6216\u5173\u8282\u7578\u5f62\uff0c\u5e94\u5236\u5b9a\u4e2a\u4f53\u5316\u6cbb\u7597\u65b9\u6848\u3002<\/li>\n\n\n\n<li>\u773c\u79d1\u95ee\u9898\uff1a\u659c\u89c6\u6216\u4e0a\u7751\u4e0b\u5782\uff08\u4e25\u91cd\u7684\u773c\u7751\u4e0b\u5782\uff09\u5e94\u57281\u5c81\u524d\u901a\u8fc7\u624b\u672f\u77eb\u6b63\uff0c\u4ee5\u9632\u5e76\u53d1\u75c7\u3002<\/li>\n\n\n\n<li>\u611f\u67d3\u98ce\u9669\uff1a\u5bf9\u4e8e\u611f\u67d3\u98ce\u9669\u9ad8\u7684\u60a3\u8005\uff0c\u5e94\u8fdb\u884c\u9002\u5f53\u6cbb\u7597\u548c\u75ab\u82d7\u63a5\u79cd\u3002<\/li>\n\n\n\n<li>\u5185\u5206\u6ccc\u95ee\u9898\uff1a\u7532\u72b6\u817a\u6fc0\u7d20\u7f3a\u4e4f\u9700\u8981\u901a\u8fc7\u8865\u5145\u6cbb\u7597\u52a0\u4ee5\u7ba1\u7406\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u96c5\u5404\u5e03\u68ee\u7efc\u5408\u5f81\u60a3\u8005\u9700\u8981 <strong>\u7ec8\u8eab\u533b\u5b66\u968f\u8bbf<\/strong>\u3002\u901a\u8fc7\u4e13\u79d1\u533b\u751f\u7684\u5b9a\u671f\u8bc4\u4f30\uff0c\u53ef\u4ee5\u5b9e\u73b0\u5bf9\u65b0\u95ee\u9898\u7684\u65e9\u671f\u53d1\u73b0\u548c\u53ca\u65f6\u5e72\u9884\u3002\u96c5\u5404\u5e03\u68ee\u7efc\u5408\u5f81\u7684\u7ba1\u7406\u4f9d\u8d56\u4e8e <strong>\u7efc\u5408\u7167\u62a4\u4e0e\u5bb6\u5ead\u652f\u6301<\/strong>\uff0c\u5728\u63a5\u53d7\u9002\u5f53\u6cbb\u7597\u7684\u60c5\u51b5\u4e0b\uff0c\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u6709\u671b\u5f97\u5230\u663e\u8457\u6539\u5584\u3002<\/p>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%9C%AA%E6%9D%A5%E5%B1%95%E6%9C%9B%EF%BC%88%E9%A2%84%E5%90%8E%EF%BC%89\"><\/span>\u672a\u6765\u5c55\u671b\uff08\u9884\u540e\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u96c5\u5404\u5e03\u68ee\u7efc\u5408\u5f81\uff08Jacobsen \u7efc\u5408\u5f81\uff0cJS\uff09\u5728\u65b0\u751f\u513f\u671f\u548c\u5a74\u513f\u671f\u5e38\u4f34\u968f\u4e25\u91cd\u7684\u5065\u5eb7\u95ee\u9898\uff0c\u8fd9\u4e9b\u65f6\u671f\u7684\u5e76\u53d1\u75c7\u5386\u6765\u662f\u4e3b\u8981\u7684\u6b7b\u4ea1\u539f\u56e0\u3002\u6700\u5e38\u89c1\u7684\u81f4\u6b7b\u56e0\u7d20\u5305\u62ec <strong>\u5148\u5929\u6027\u5fc3\u810f\u75c5\u3001\u56e0\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u5f15\u8d77\u7684\u4e25\u91cd\u51fa\u8840\u4ee5\u53ca\u514d\u75ab\u7f3a\u9677<\/strong>\u3002\u65e9\u671f\u8bca\u65ad\u6781\u5176\u91cd\u8981\uff0c\u56e0\u4e3a\u5b83\u53ef\u4ee5\u5728\u5173\u952e\u65f6\u523b\u5b9e\u65bd\u6551\u547d\u5e72\u9884\u3002\u8fd9\u4e9b\u5e72\u9884\u63aa\u65bd\u5305\u62ec\uff1a\u5728\u9ad8\u51fa\u8840\u98ce\u9669\u7684\u60c5\u51b5\u4e0b\u8fdb\u884c\u9884\u9632\u6027\u8840\u5c0f\u677f\u8f93\u6ce8\uff0c\u4e3a\u9884\u9632\u5371\u53ca\u751f\u547d\u7684\u611f\u67d3\u800c\u4f7f\u7528\u6297\u751f\u7d20\u6216\u9759\u8109\u6ce8\u5c04\u514d\u75ab\u7403\u86cb\u767d\uff08IVIG\uff09\uff0c\u4ee5\u53ca\u5bf9\u590d\u6742\u7684\u5148\u5929\u6027\u5fc3\u810f\u75c5\u8fdb\u884c\u65e9\u671f\u533b\u5b66\u6216\u5916\u79d1\u6cbb\u7597\u3002\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0c\u8fd8\u53ef\u80fd\u901a\u8fc7\u8111\u90e8\u5f71\u50cf\u5b66\u68c0\u67e5\u6765\u53d1\u73b0\u5982\u8111\u52a8\u8109\u7624\u7b49\u6f5c\u5728\u5371\u53ca\u751f\u547d\u7684\u5f02\u5e38\u3002<\/p>\n\n\n\n<p>JS \u7684\u9884\u540e\u56e0\u4eba\u800c\u5f02\u3002\u90e8\u5206\u60a3\u6709\u4e25\u91cd\u5fc3\u810f\u7578\u5f62\u6216\u51fa\u8840\u5e76\u53d1\u75c7\u7684\u513f\u7ae5\u53ef\u80fd\u65e0\u6cd5\u5b58\u6d3b\u5230\u65b0\u751f\u513f\u671f\u3002\u800c\u80fd\u591f\u5ea6\u8fc7\u65b0\u751f\u513f\u671f\u7684\u60a3\u8005\uff0c\u5219\u9700\u8981\u6301\u7eed\u7684\u533b\u7597\u62a4\u7406\u548c\u5e72\u9884\uff0c\u4ee5\u5e94\u5bf9\u4e0e\u8be5\u7efc\u5408\u5f81\u76f8\u5173\u7684\u590d\u6742\u75c7\u72b6\u548c\u5065\u5eb7\u72b6\u51b5\u3002<strong>\u667a\u529b\u969c\u788d<\/strong> \u662f JS \u7684\u5e38\u89c1\u7279\u5f81\uff0c\u5176\u4e25\u91cd\u7a0b\u5ea6\u53ef\u4ece\u8f7b\u5ea6\u5230\u91cd\u5ea6\u4e0d\u7b49\u3002<\/p>\n\n\n\n<p>\u76ee\u524d JS \u60a3\u8005\u7684\u5e73\u5747\u5bff\u547d\u4ecd\u4e0d\u660e\u786e\uff0c\u4f46\u968f\u7740\u533b\u7597\u6c34\u5e73\u7684\u63d0\u9ad8\uff0c\u8d8a\u6765\u8d8a\u591a\u60a3\u8005\u7684\u9884\u540e\u5f97\u4ee5\u6539\u5584\u3002\u636e\u62a5\u9053\uff0c\u5df2\u77e5\u5bff\u547d\u6700\u957f\u7684 JS \u60a3\u8005\u81f3\u5c11\u6d3b\u5230\u4e86 45 \u5c81\uff0c\u8fd9\u8868\u660e\u5728\u9002\u5f53\u7ba1\u7406\u7684\u60c5\u51b5\u4e0b\uff0c\u957f\u671f\u5b58\u6d3b\u662f\u53ef\u80fd\u7684\u3002\u4e3a\u4e86\u6ee1\u8db3 JS \u60a3\u8005\u7684\u533b\u7597\u548c\u53d1\u80b2\u9700\u6c42\uff0c<strong>\u5b9a\u671f\u76d1\u6d4b<\/strong> \u4ee5\u53ca <strong>\u591a\u5b66\u79d1\u56e2\u961f\u7684\u7efc\u5408\u6cbb\u7597<\/strong> \u662f\u5fc5\u4e0d\u53ef\u5c11\u7684\u3002\u8fd9\u79cd\u957f\u671f\u7167\u62a4\u5bf9\u4e8e\u652f\u6301\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u548c\u6574\u4f53\u5065\u5eb7\u72b6\u51b5\u81f3\u5173\u91cd\u8981\u3002<\/p>\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/nipt\/wp-content\/uploads\/2024\/11\/24156031_s.jpg\" alt=\"\u5b50\u3069\u3082\u3092\u611b\u3055\u306a\u3044\u3068\" class=\"wp-image-87708\"\/><\/figure><\/div>\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%BC%95%E7%94%A8%E6%96%87%E7%8C%AE\"><\/span>\u5f15\u7528\u6587\u732e<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1186\/1750-1172-4-9\">Mattina, T., Perrotta, C. S., &amp; Grossfeld, P. (2009). Jacobsen syndrome.&nbsp;<em>Orphanet Journal of Rare Diseases<\/em>,&nbsp;<em>4<\/em>(1), 9. https:\/\/doi.org\/10.1186\/1750-1172-4-9<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.5603\/ahp.96831\">Jatczak-Gaca, A. (2023). Hematological aberrations in patient with Jacobsen syndrome. <em>Acta Haematologica Polonica<\/em>, VM\/OJS\/J\/96831. https:\/\/doi.org\/10.5603\/ahp.96831<\/a><\/li>\n\n\n\n<li><a href=\"http:\/\/10.1111\/j.1399-0004.1996.tb02715.x\">Ono, J., Hasegawa, T., Sugama, S., Sagehashi, N., Hase, Y., Oku, K., \u2026 Okada, S. (2008). Partial deletion of the long arm of chromosome 11: ten Japanese children. Clinical Genetics, 50(6), 474\u2013478. doi:10.1111\/j.1399-0004.1996.tb02715.x&nbsp;<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.orpha.net\/en\/disease\/detail\/2308?name=Jacobsen&amp;mode=name\">Orphanet. (Last updated March 2020). <em>Jacobsen syndrome.<\/em> Reviewed by Prof. Paul GROSSFELD. Retrieved from https:\/\/www.orpha.net\/en\/disease\/detail\/2308?name=Jacobsen&amp;mode=name<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae974\">Perez, G., Barber, G. P., Benet-Pages, A., Casper, J., Clawson, H., Diekhans, M., Fischer, C., Gonzalez, J. N., Hinrichs, A. S., Lee, C. M., Nassar, L. R., Raney, B. J., Speir, M. L., van Baren, M. J., Vaske, C. J., Haussler, D., Kent, W. J., &amp; Haeussler, M. (2024). The UCSC Genome Browser database: 2025 update. Nucleic Acids Research, gkae974. https:\/\/doi.org\/10.1093\/nar\/gkae974<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1049\">Harrison, P. W., Amode, M. R., Austine-Orimoloye, O., Azov, A. G., Barba, M., Barnes, I., Becker, A., Bennett, R., Berry, A., Bhai, J., Bhurji, S. K., Boddu, S., Branco Lins, P. R., Brooks, L., Budhanuru Ramaraju, S., Campbell, L. I., Carbajo Martinez, M., Charkhchi, M., Chougule, K., \u2026 Yates, A. D. (2024). Ensembl 2024. Nucleic Acids Research, 52(D1), D891\u2013D899. https:\/\/doi.org\/10.1093\/nar\/gkad1049<\/a><\/li>\n<\/ul>\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"\u3053\u306e\u8a18\u4e8b\u306e\u307e\u3068\u3081\u30e4\u30b3\u30d6\u30bb\u30f3\u75c7\u5019\u7fa4\u306f\u3001\u7279\u5fb4&#8230;\n <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/jacobsen\/?lang=zh-hans\">\u7d9a\u304d\u3092\u8aad\u3080<\/a>","protected":false},"author":101,"featured_media":88826,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[14],"tags":[],"class_list":["post-111866","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-other-zh-hans"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/111866","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/users\/101"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/comments?post=111866"}],"version-history":[{"count":3,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/111866\/revisions"}],"predecessor-version":[{"id":111905,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/111866\/revisions\/111905"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media\/88826"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=111866"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/categories?post=111866"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/tags?post=111866"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}