{"id":116062,"date":"2025-09-24T17:15:41","date_gmt":"2025-09-24T08:15:41","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/?p=116062"},"modified":"2025-09-24T17:15:43","modified_gmt":"2025-09-24T08:15:43","slug":"nipt-chromosome-abnormality","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/","title":{"rendered":"NIPT\u3067\u308f\u304b\u308b\u67d3\u8272\u4f53\u7570\u5e38\u306e\u7a2e\u985e"},"content":{"rendered":"\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#%E3%81%AF%E3%81%98%E3%82%81%E3%81%AB\" >\u306f\u3058\u3081\u306b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#1_NIPT%E3%81%A8%E3%81%AF\" >1. NIPT\u3068\u306f<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#NIPT%E3%81%AE%E6%A4%9C%E6%9F%BB%E6%96%B9%E6%B3%95\" >NIPT\u306e\u691c\u67fb\u65b9\u6cd5<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#2_NIPT%E3%81%A7%E3%82%8F%E3%81%8B%E3%82%8B%E6%9F%93%E8%89%B2%E4%BD%93%E7%95%B0%E5%B8%B8%E3%81%AE%E7%A8%AE%E9%A1%9E\" >2. NIPT\u3067\u308f\u304b\u308b\u67d3\u8272\u4f53\u7570\u5e38\u306e\u7a2e\u985e<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#2-1_21%E3%83%88%E3%83%AA%E3%82%BD%E3%83%9F%E3%83%BC%EF%BC%88%E3%83%80%E3%82%A6%E3%83%B3%E7%97%87%E5%80%99%E7%BE%A4%EF%BC%89\" >2-1. 21\u30c8\u30ea\u30bd\u30df\u30fc\uff08\u30c0\u30a6\u30f3\u75c7\u5019\u7fa4\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#2-2_18%E3%83%88%E3%83%AA%E3%82%BD%E3%83%9F%E3%83%BC%EF%BC%88%E3%82%A8%E3%83%89%E3%83%AF%E3%83%BC%E3%82%BA%E7%97%87%E5%80%99%E7%BE%A4%EF%BC%89\" >2-2. 18\u30c8\u30ea\u30bd\u30df\u30fc\uff08\u30a8\u30c9\u30ef\u30fc\u30ba\u75c7\u5019\u7fa4\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#2-3_13%E3%83%88%E3%83%AA%E3%82%BD%E3%83%9F%E3%83%BC%EF%BC%88%E3%83%91%E3%83%88%E3%82%A6%E7%97%87%E5%80%99%E7%BE%A4%EF%BC%89\" >2-3. 13\u30c8\u30ea\u30bd\u30df\u30fc\uff08\u30d1\u30c8\u30a6\u75c7\u5019\u7fa4\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#2-4_%E6%80%A7%E6%9F%93%E8%89%B2%E4%BD%93%E7%95%B0%E5%B8%B8\" >2-4. \u6027\u67d3\u8272\u4f53\u7570\u5e38<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#3_NIPT%E3%81%A7%E6%A4%9C%E5%87%BA%E5%8F%AF%E8%83%BD%E3%81%AA%E5%BE%AE%E7%B4%B0%E6%9F%93%E8%89%B2%E4%BD%93%E7%95%B0%E5%B8%B8\" >3. NIPT\u3067\u691c\u51fa\u53ef\u80fd\u306a\u5fae\u7d30\u67d3\u8272\u4f53\u7570\u5e38<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#4_NIPT%E3%81%AE%E7%B2%BE%E5%BA%A6%E3%81%A8%E9%99%90%E7%95%8C\" >4. NIPT\u306e\u7cbe\u5ea6\u3068\u9650\u754c<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#4-1_%E7%B2%BE%E5%BA%A6\" >4-1. \u7cbe\u5ea6<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#4-2_%E9%99%90%E7%95%8C\" >4-2. \u9650\u754c<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#5_NIPT%E3%82%92%E5%8F%97%E3%81%91%E3%82%8B%E3%82%BF%E3%82%A4%E3%83%9F%E3%83%B3%E3%82%B0%E3%81%A8%E6%B5%81%E3%82%8C\" >5. NIPT\u3092\u53d7\u3051\u308b\u30bf\u30a4\u30df\u30f3\u30b0\u3068\u6d41\u308c<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#6_%E6%A4%9C%E6%9F%BB%E9%81%B8%E6%8A%9E%E6%99%82%E3%81%AE%E6%B3%A8%E6%84%8F%E7%82%B9\" >6. \u691c\u67fb\u9078\u629e\u6642\u306e\u6ce8\u610f\u70b9<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#7_%E3%81%93%E3%81%93%E3%81%BE%E3%81%A7%E3%81%AE%E3%81%BE%E3%81%A8%E3%82%81\" >7. \u3053\u3053\u307e\u3067\u306e\u307e\u3068\u3081<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#8_NIPT%E3%81%AE%E6%9C%80%E6%96%B0%E6%8A%80%E8%A1%93%E3%81%A8%E5%A4%9A%E6%A7%98%E5%8C%96%E3%81%99%E3%82%8B%E6%A4%9C%E6%9F%BB%E7%AF%84%E5%9B%B2\" >8. NIPT\u306e\u6700\u65b0\u6280\u8853\u3068\u591a\u69d8\u5316\u3059\u308b\u691c\u67fb\u7bc4\u56f2<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#8-1_%E3%83%9E%E3%82%A4%E3%82%AF%E3%83%AD%E3%82%A2%E3%83%AC%E3%82%A4%E8%A7%A3%E6%9E%90%E3%81%A8%E3%81%AE%E4%BD%B5%E7%94%A8\" >8-1. \u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4\u89e3\u6790\u3068\u306e\u4f75\u7528<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#8-2_%E6%80%A7%E6%9F%93%E8%89%B2%E4%BD%93%E7%95%B0%E5%B8%B8%E3%81%AE%E7%B2%BE%E5%BA%A6%E5%90%91%E4%B8%8A\" >8-2. \u6027\u67d3\u8272\u4f53\u7570\u5e38\u306e\u7cbe\u5ea6\u5411\u4e0a<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#9_NIPT%E3%81%AE%E7%B5%B1%E8%A8%88%E3%81%A8%E5%8F%97%E6%A4%9C%E7%8A%B6%E6%B3%81\" >9. NIPT\u306e\u7d71\u8a08\u3068\u53d7\u691c\u72b6\u6cc1<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#10_NIPT%E3%82%92%E5%8F%97%E3%81%91%E3%82%8B%E9%9A%9B%E3%81%AE%E5%80%AB%E7%90%86%E7%9A%84%E9%85%8D%E6%85%AE\" >10. NIPT\u3092\u53d7\u3051\u308b\u969b\u306e\u502b\u7406\u7684\u914d\u616e<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#11_NIPT%E3%81%AE%E8%B2%BB%E7%94%A8%E3%81%A8%E4%BF%9D%E9%99%BA%E9%81%A9%E7%94%A8\" >11. NIPT\u306e\u8cbb\u7528\u3068\u4fdd\u967a\u9069\u7528<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#12_NIPT%E3%81%AE%E6%A4%9C%E6%9F%BB%E9%81%B8%E6%8A%9E%E3%81%AE%E3%83%9D%E3%82%A4%E3%83%B3%E3%83%88\" >12. NIPT\u306e\u691c\u67fb\u9078\u629e\u306e\u30dd\u30a4\u30f3\u30c8<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#13_%E3%81%BE%E3%81%A8%E3%82%81\" >13. \u307e\u3068\u3081<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/#%E5%8F%82%E8%80%83%E6%96%87%E7%8C%AE\" >\u53c2\u8003\u6587\u732e<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%81%AF%E3%81%98%E3%82%81%E3%81%AB\"><\/span><strong>\u306f\u3058\u3081\u306b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u598a\u5a20\u4e2d\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b<strong><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>\uff08Non-Invasive Prenatal Testing\uff1a\u975e\u4fb5\u8972\u7684\u51fa\u751f\u524d\u907a\u4f1d\u5b66\u7684\u691c\u67fb\uff09\u306f\u3001\u6bcd\u4f53\u306e\u8840\u6db2\u304b\u3089\u80ce\u5150\u306eDNA\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u3055\u307e\u3056\u307e\u306a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a><\/strong>\u3092\u65e9\u671f\u306b\u78ba\u8a8d\u3067\u304d\u308b\u753b\u671f\u7684\u306a\u691c\u67fb\u65b9\u6cd5\u3067\u3059\u3002\u5f93\u6765\u306e\u4fb5\u8972\u7684\u691c\u67fb\u3067\u3042\u308b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-clinic\/amniocentesis\/\">\u7f8a\u6c34\u691c\u67fb<\/a>\u3084<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chorionic-villus-test\/\">\u7d68\u6bdb\u691c\u67fb<\/a>\u306b\u6bd4\u3079\u3001\u6bcd\u4f53\u3084\u80ce\u5150\u3078\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u304f\u3001\u7cbe\u5ea6\u3082\u9ad8\u3044\u3053\u3068\u304b\u3089\u3001\u591a\u304f\u306e\u598a\u5a66\u304c\u9078\u629e\u3059\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u672c\u8a18\u4e8b\u3067\u306f\u3001NIPT\u3067\u691c\u51fa\u53ef\u80fd\u306a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u7a2e\u985e\u3001\u691c\u67fb\u306e\u4ed5\u7d44\u307f\u3001\u7cbe\u5ea6\u3084\u9650\u754c\u3001\u691c\u67fb\u306e\u9078\u629e\u306b\u304a\u3051\u308b\u6ce8\u610f\u70b9\u306a\u3069\u3092\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_NIPT%E3%81%A8%E3%81%AF\"><\/span><strong>1. NIPT\u3068\u306f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>NIPT\u306f\u598a\u5a66\u306e\u8840\u6db2\u4e2d\u306b\u5fae\u91cf\u306b\u5b58\u5728\u3059\u308b**\u80ce\u5150\u7531\u6765\u306e\u904a\u96e2DNA\uff08cfDNA\uff09**\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u80ce\u5150\u306e\u67d3\u8272\u4f53\u6570\u7570\u5e38\u3092\u63a8\u5b9a\u3059\u308b\u691c\u67fb\u3067\u3059\u3002<br>\u6bcd\u4f53\u8840\u6db2\u4e2d\u306e\u80ce\u5150DNA\u306f\u598a\u5a20\u521d\u671f\u304b\u3089\u691c\u51fa\u53ef\u80fd\u3067\u3042\u308a\u3001<strong>\u598a\u5a2010\u9031\u4ee5\u964d<\/strong>\u306b\u691c\u67fb\u3059\u308b\u306e\u304c\u4e00\u822c\u7684\u3067\u3059\u3002\u4fb5\u8972\u7684\u691c\u67fb\u306b\u6bd4\u3079\u3066<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306e\u30ea\u30b9\u30af\u304c\u307b\u307c\u306a\u3044\u70b9\u304c\u5927\u304d\u306a\u7279\u5fb4\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"NIPT%E3%81%AE%E6%A4%9C%E6%9F%BB%E6%96%B9%E6%B3%95\"><\/span><strong>NIPT\u306e\u691c\u67fb\u65b9\u6cd5<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u6bcd\u4f53\u304b\u3089\u8840\u6db2\u3092\u63a1\u53d6<br><\/li>\n\n\n\n<li>cfDNA\u306e\u62bd\u51fa<br><\/li>\n\n\n\n<li>\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b9\uff08NGS\uff09\u306a\u3069\u306b\u3088\u308b\u67d3\u8272\u4f53\u89e3\u6790<br><\/li>\n\n\n\n<li>\u67d3\u8272\u4f53\u6570\u7570\u5e38\u306e\u6709\u7121\u3092\u8a55\u4fa1<br><\/li>\n<\/ol>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_NIPT%E3%81%A7%E3%82%8F%E3%81%8B%E3%82%8B%E6%9F%93%E8%89%B2%E4%BD%93%E7%95%B0%E5%B8%B8%E3%81%AE%E7%A8%AE%E9%A1%9E\"><\/span><strong>2. NIPT\u3067\u308f\u304b\u308b\u67d3\u8272\u4f53\u7570\u5e38\u306e\u7a2e\u985e<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>NIPT\u306f\u4e3b\u306b<strong>\u80ce\u5150\u306e\u6570\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a><\/strong>\uff08\u30c8\u30ea\u30bd\u30df\u30fc\u3084\u30e2\u30ce\u30bd\u30df\u30fc\uff09\u3092\u691c\u51fa\u3057\u307e\u3059\u3002\u3053\u3053\u3067\u306f\u4ee3\u8868\u7684\u306a\u7570\u5e38\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2-1_21%E3%83%88%E3%83%AA%E3%82%BD%E3%83%9F%E3%83%BC%EF%BC%88%E3%83%80%E3%82%A6%E3%83%B3%E7%97%87%E5%80%99%E7%BE%A4%EF%BC%89\"><\/span><strong>2-1. 21\u30c8\u30ea\u30bd\u30df\u30fc\uff08\u30c0\u30a6\u30f3\u75c7\u5019\u7fa4\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>21\u30c8\u30ea\u30bd\u30df\u30fc<\/strong>\u306f\u6700\u3082\u983b\u5ea6\u306e\u9ad8\u3044<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3067\u300121\u756a\u67d3\u8272\u4f53\u304c1\u672c\u4f59\u5206\u306b\u5b58\u5728\u3059\u308b\u3053\u3068\u3067\u767a\u75c7\u3057\u307e\u3059\u3002<br>\u7279\u5fb4\u7684\u306a\u8eab\u4f53\u7684\u75c7\u72b6\u3068\u3057\u3066\u306f\u3001\u4f4e\u8eab\u9577\u3001\u5e73\u5766\u306a\u9854\u8c8c\u3001\u773c\u88c2\u306e\u7570\u5e38\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/why-premium-plan\/\">\u77e5\u7684\u969c\u5bb3<\/a>\u306a\u3069\u304c\u3042\u308a\u307e\u3059\u3002<br>NIPT\u3067\u306f\u611f\u5ea699\uff05\u4ee5\u4e0a\u3001\u7279\u7570\u5ea699\uff05\u4ee5\u4e0a\u3068\u975e\u5e38\u306b\u9ad8\u7cbe\u5ea6\u3067\u691c\u51fa\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e: Bianchi DW et al., <em>N Engl J Med<\/em>, 2014;370:799-808. Link<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2-2_18%E3%83%88%E3%83%AA%E3%82%BD%E3%83%9F%E3%83%BC%EF%BC%88%E3%82%A8%E3%83%89%E3%83%AF%E3%83%BC%E3%82%BA%E7%97%87%E5%80%99%E7%BE%A4%EF%BC%89\"><\/span><strong>2-2. 18\u30c8\u30ea\u30bd\u30df\u30fc\uff08\u30a8\u30c9\u30ef\u30fc\u30ba\u75c7\u5019\u7fa4\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a><\/strong>\u306f18\u756a\u67d3\u8272\u4f53\u304c1\u672c\u591a\u3044\u3053\u3068\u306b\u3088\u308a\u767a\u75c7\u3057\u307e\u3059\u3002\u91cd\u7be4\u306a\u5fc3\u5947\u5f62\u3084\u814e\u5947\u5f62\u3001\u767a\u9054\u9045\u6ede\u306a\u3069\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u51fa\u751f\u5f8c\u306e\u751f\u5b58\u671f\u9593\u304c\u77ed\u3044\u5834\u5408\u304c\u591a\u3044\u3067\u3059\u3002<br>NIPT\u306b\u3088\u308b\u691c\u51fa\u7cbe\u5ea6\u3082\u9ad8\u304f\u3001\u611f\u5ea6\u7d0497\u301c99\uff05\u3001\u7279\u7570\u5ea6\u7d0499\uff05\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e: Palomaki GE et al., <em>Genet Med<\/em>, 2012;14:296-305.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2-3_13%E3%83%88%E3%83%AA%E3%82%BD%E3%83%9F%E3%83%BC%EF%BC%88%E3%83%91%E3%83%88%E3%82%A6%E7%97%87%E5%80%99%E7%BE%A4%EF%BC%89\"><\/span><strong>2-3. 13\u30c8\u30ea\u30bd\u30df\u30fc\uff08\u30d1\u30c8\u30a6\u75c7\u5019\u7fa4\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a><\/strong>\u306f13\u756a\u67d3\u8272\u4f53\u304c1\u672c\u591a\u304f\u306a\u308b\u3053\u3068\u3067\u767a\u75c7\u3057\u307e\u3059\u3002\u591a\u304f\u306e\u5148\u5929\u7570\u5e38\u3092\u4f34\u3044\u3001\u751f\u5b58\u671f\u9593\u304c\u77ed\u3044\u3053\u3068\u304c\u7279\u5fb4\u3067\u3059\u3002<br>NIPT\u3067\u306e\u691c\u51fa\u7cbe\u5ea6\u3082\u9ad8\u304f\u3001\u611f\u5ea6\u306f\u7d0490\u301c95\uff05\u3001\u7279\u7570\u5ea6\u306f99\uff05\u7a0b\u5ea6\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2-4_%E6%80%A7%E6%9F%93%E8%89%B2%E4%BD%93%E7%95%B0%E5%B8%B8\"><\/span><strong>2-4. \u6027\u67d3\u8272\u4f53\u7570\u5e38<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u6027\u67d3\u8272\u4f53\uff08X\u30fbY\u67d3\u8272\u4f53\uff09\u306e\u7570\u5e38\u3082NIPT\u3067\u691c\u51fa\u53ef\u80fd\u3067\u3059\u3002\u4e3b\u306a\u75be\u60a3\u306b\u306f\u4ee5\u4e0b\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30bf\u30fc\u30ca\u30fc\u75c7\u5019\u7fa4\uff0845,X\uff09<\/strong>\uff1a\u5973\u6027\u3067X\u67d3\u8272\u4f53\u304c1\u672c\u6b20\u640d\u3002\u8eab\u9577\u4f4e\u4e0b\u3001\u5375\u5de3\u6a5f\u80fd\u4e0d\u5168\u306a\u3069\u3092\u5448\u3057\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/klinefelter-syndrome\/\">\u30af\u30e9\u30a4\u30f3\u30d5\u30a7\u30eb\u30bf\u30fc\u75c7\u5019\u7fa4<\/a>\uff0847,XXY\uff09<\/strong>\uff1a\u7537\u6027\u3067X\u67d3\u8272\u4f53\u304c1\u672c\u591a\u3044\u3002\u9ad8\u8eab\u9577\u3001\u7cbe\u5b50\u5f62\u6210\u4e0d\u5168\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/learning-disabilities-genetics-support\/\">\u5b66\u7fd2\u969c\u5bb3<\/a>\u306e\u30ea\u30b9\u30af\u304c\u3042\u308a\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u30c8\u30ea\u30d7\u30ebX\u75c7\u5019\u7fa4\uff0847,XXX\uff09<\/strong>\uff1a\u5973\u6027\u3067X\u67d3\u8272\u4f53\u304c1\u672c\u591a\u3044\u3002\u8efd\u5ea6\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/why-premium-plan\/\">\u77e5\u7684\u969c\u5bb3<\/a>\u3084\u751f\u6b96\u6a5f\u80fd\u7570\u5e38\u306e\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u30b8\u30e3\u30b3\u30d6\u75c7\u5019\u7fa4\uff0847,XYY\uff09<\/strong>\uff1a\u7537\u6027\u3067Y\u67d3\u8272\u4f53\u304c1\u672c\u591a\u3044\u3002\u8eab\u4f53\u7684\u7570\u5e38\u306f\u8efd\u5ea6\u3067\u3001\u77e5\u80fd\u3078\u306e\u5f71\u97ff\u306f\u8efd\u5fae\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br><\/li>\n<\/ul>\n\n\n\n<p>\u53c2\u8003\u6587\u732e: Norton ME et al., <em>N Engl J Med<\/em>, 2015;372:1589-1597. <\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_NIPT%E3%81%A7%E6%A4%9C%E5%87%BA%E5%8F%AF%E8%83%BD%E3%81%AA%E5%BE%AE%E7%B4%B0%E6%9F%93%E8%89%B2%E4%BD%93%E7%95%B0%E5%B8%B8\"><\/span><strong>3. NIPT\u3067\u691c\u51fa\u53ef\u80fd\u306a\u5fae\u7d30\u67d3\u8272\u4f53\u7570\u5e38<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u8fd1\u5e74\u306e\u6280\u8853\u9032\u6b69\u306b\u3088\u308a\u3001\u5f93\u6765\u306e\u30c8\u30ea\u30bd\u30df\u30fc\u3084\u30e2\u30ce\u30bd\u30df\u30fc\u3060\u3051\u3067\u306a\u304f\u3001\u5fae\u7d30\u6b20\u5931\u30fb\u91cd\u8907\uff08\u30de\u30a4\u30af\u30ed\u30c7\u30ec\u30c3\u30c8\u3084\u30de\u30a4\u30af\u30ed\u30c7\u30e5\u30d7\u30ea\u30b1\u30fc\u30b7\u30e7\u30f3\uff09\u3082\u4e00\u90e8\u691c\u51fa\u53ef\u80fd\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<br>\u4f8b\u3048\u3070\u300122q11.2\u6b20\u5931\u75c7\u5019\u7fa4\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/microdeletion-syndrome\/\">\u30c7\u30a3\u30b8\u30e7\u30fc\u30b8\u75c7\u5019\u7fa4<\/a>\uff09\u306f\u5fc3\u5947\u5f62\u3084\u514d\u75ab\u7570\u5e38\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/why-premium-plan\/\">\u77e5\u7684\u969c\u5bb3<\/a>\u3092\u4f34\u3046\u67d3\u8272\u4f53\u5fae\u7d30\u6b20\u5931\u75c7\u3067\u3001NIPT\u3067\u306e\u691c\u51fa\u304c\u8a66\u307f\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e: Liang D et al., <em>Prenat Diagn<\/em>, 2018;38:789-797. <\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001\u5fae\u7d30\u7570\u5e38\u306e\u691c\u51fa\u306f\u611f\u5ea6\u304c\u4f4e\u304f\u3001\u507d\u967d\u6027\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u305f\u3081\u3001\u967d\u6027\u7d50\u679c\u304c\u51fa\u305f\u5834\u5408\u306f<strong><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-clinic\/amniocentesis\/\">\u7f8a\u6c34\u691c\u67fb<\/a>\u3084<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chorionic-villus-test\/\">\u7d68\u6bdb\u691c\u67fb<\/a>\u3067\u306e\u78ba\u5b9a\u8a3a\u65ad<\/strong>\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4_NIPT%E3%81%AE%E7%B2%BE%E5%BA%A6%E3%81%A8%E9%99%90%E7%95%8C\"><\/span><strong>4. NIPT\u306e\u7cbe\u5ea6\u3068\u9650\u754c<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4-1_%E7%B2%BE%E5%BA%A6\"><\/span><strong>4-1. \u7cbe\u5ea6<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>21\u30c8\u30ea\u30bd\u30df\u30fc<\/strong>\uff1a\u611f\u5ea699\uff05\u4ee5\u4e0a\u3001\u7279\u7570\u5ea699\uff05\u4ee5\u4e0a<br><\/li>\n\n\n\n<li><strong><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a><\/strong>\uff1a\u611f\u5ea6\u7d0497\u301c99\uff05\u3001\u7279\u7570\u5ea6\u7d0499\uff05<br><\/li>\n\n\n\n<li><strong><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a><\/strong>\uff1a\u611f\u5ea6\u7d0490\u301c95\uff05\u3001\u7279\u7570\u5ea6\u7d0499\uff05<br><\/li>\n\n\n\n<li><strong>\u6027<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a><\/strong>\uff1a\u611f\u5ea685\u301c95\uff05\u3001\u7279\u7570\u5ea699\uff05<br><\/li>\n<\/ul>\n\n\n\n<p>\u53c2\u8003\u6587\u732e: Gil MM et al., <em>Ultrasound Obstet Gynecol<\/em>, 2015;45:530-539. <\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4-2_%E9%99%90%E7%95%8C\"><\/span><strong>4-2. \u9650\u754c<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u507d\u967d\u6027\u30fb\u507d\u9670\u6027<\/strong><strong><br><\/strong> cfDNA\u306f\u6bcd\u4f53\u7531\u6765\u3082\u6df7\u5728\u3059\u308b\u305f\u3081\u3001\u6bcd\u4f53\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3084\u816b\u760d\u306b\u3088\u308b\u5f71\u97ff\u3067\u7d50\u679c\u304c\u8aa4\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u5fae\u7d30<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u691c\u51fa\u9650\u754c<\/strong><strong><br><\/strong> 5\u301c10Mb\u4ee5\u4e0b\u306e\u5fae\u7d30\u6b20\u5931\u30fb\u91cd\u8907\u306f\u691c\u51fa\u56f0\u96e3\u3067\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u78ba\u5b9a\u8a3a\u65ad\u306b\u306f\u4e0d\u53ef<\/strong><strong><br><\/strong> NIPT\u306f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u691c\u67fb\u3067\u3042\u308a\u3001\u967d\u6027\u7d50\u679c\u304c\u51fa\u305f\u5834\u5408\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-clinic\/amniocentesis\/\">\u7f8a\u6c34\u691c\u67fb<\/a>\u306a\u3069\u3067\u306e<strong>\u78ba\u5b9a\u8a3a\u65ad<\/strong>\u304c\u5fc5\u8981\u3067\u3059\u3002<br><\/li>\n<\/ol>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"5_NIPT%E3%82%92%E5%8F%97%E3%81%91%E3%82%8B%E3%82%BF%E3%82%A4%E3%83%9F%E3%83%B3%E3%82%B0%E3%81%A8%E6%B5%81%E3%82%8C\"><\/span><strong>5. NIPT\u3092\u53d7\u3051\u308b\u30bf\u30a4\u30df\u30f3\u30b0\u3068\u6d41\u308c<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u598a\u5a2010\u9031\u4ee5\u964d\u306b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/pregnancy-checkups-frequency-and-details\/\">\u598a\u5a66\u5065\u8a3a<\/a>\u3067\u533b\u5e2b\u306b\u76f8\u8ac7<br><\/li>\n\n\n\n<li>\u8840\u6db2\u63a1\u53d6<br><\/li>\n\n\n\n<li>\u691c\u67fb\u6a5f\u95a2\u306b\u9001\u4ed8<br><\/li>\n\n\n\n<li>\u7d50\u679c\u5831\u544a\uff08\u901a\u5e381\u301c2\u9031\u9593\uff09<br><\/li>\n\n\n\n<li>\u967d\u6027\u306e\u5834\u5408\u306f\u533b\u5e2b\u3068\u76f8\u8ac7\u3057\u3001\u78ba\u5b9a\u8a3a\u65ad\u3092\u691c\u8a0e<br><\/li>\n<\/ol>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/nipt\/wp-content\/uploads\/2025\/09\/32943421_s.webp\" alt=\"\u598a\u5a66\" class=\"wp-image-116072\"\/><\/figure><\/div>\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"6_%E6%A4%9C%E6%9F%BB%E9%81%B8%E6%8A%9E%E6%99%82%E3%81%AE%E6%B3%A8%E6%84%8F%E7%82%B9\"><\/span><strong>6. \u691c\u67fb\u9078\u629e\u6642\u306e\u6ce8\u610f\u70b9<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>NIPT\u306f\u9ad8\u7cbe\u5ea6\u3067\u3059\u304c\u3001<strong>\u78ba\u5b9a\u8a3a\u65ad\u3067\u306f\u306a\u3044<\/strong>\u3053\u3068\u3092\u7406\u89e3\u3059\u308b<br><\/li>\n\n\n\n<li>\u6027<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3084\u5fae\u7d30<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306f\u691c\u51fa\u7cbe\u5ea6\u304c\u4f4e\u3081<br><\/li>\n\n\n\n<li>\u691c\u67fb\u5bfe\u8c61\u3068\u306a\u308b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306f\u65bd\u8a2d\u3084\u691c\u67fb\u4f1a\u793e\u306b\u3088\u3063\u3066\u7570\u306a\u308b<br><\/li>\n\n\n\n<li>\u7d50\u679c\u306b\u3088\u308a\u5fc3\u7406\u7684\u5f71\u97ff\u304c\u5927\u304d\u3044\u305f\u3081\u3001<strong>\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0<\/strong>\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u671b\u307e\u3057\u3044<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"7_%E3%81%93%E3%81%93%E3%81%BE%E3%81%A7%E3%81%AE%E3%81%BE%E3%81%A8%E3%82%81\"><\/span><strong>7. \u3053\u3053\u307e\u3067\u306e\u307e\u3068\u3081<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>NIPT\u306f\u598a\u5a66\u306b\u3068\u3063\u3066\u6bcd\u4f53\u3084\u80ce\u5150\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u304f\u300121\u30c8\u30ea\u30bd\u30df\u30fc\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u306a\u3069\u306e\u4e3b\u8981\u306a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3092\u9ad8\u7cbe\u5ea6\u3067\u691c\u51fa\u3067\u304d\u308b\u753b\u671f\u7684\u306a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u3067\u3059\u3002\u8fd1\u5e74\u306f\u5fae\u7d30<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u691c\u51fa\u3082\u53ef\u80fd\u3068\u306a\u308a\u3001\u3088\u308a\u5e45\u5e83\u3044\u7570\u5e38\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001<strong>\u78ba\u5b9a\u8a3a\u65ad\u3067\u306f\u306a\u304f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u691c\u67fb<\/strong>\u3067\u3042\u308b\u70b9\u3001\u5fae\u7d30\u7570\u5e38\u3084\u6027<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u7cbe\u5ea6\u306b\u306f\u9650\u754c\u304c\u3042\u308b\u70b9\u3092\u7406\u89e3\u3057\u305f\u4e0a\u3067\u691c\u67fb\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002NIPT\u306f\u533b\u5e2b\u3084\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30e9\u30fc\u3068\u76f8\u8ac7\u3057\u306a\u304c\u3089\u9069\u5207\u306b\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u51fa\u751f\u524d\u8a3a\u7642\u306e\u9078\u629e\u80a2\u3092\u5e83\u3052\u3001\u5b89\u5fc3\u3057\u305f\u598a\u5a20\u7ba1\u7406\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"8_NIPT%E3%81%AE%E6%9C%80%E6%96%B0%E6%8A%80%E8%A1%93%E3%81%A8%E5%A4%9A%E6%A7%98%E5%8C%96%E3%81%99%E3%82%8B%E6%A4%9C%E6%9F%BB%E7%AF%84%E5%9B%B2\"><\/span><strong>8. NIPT\u306e\u6700\u65b0\u6280\u8853\u3068\u591a\u69d8\u5316\u3059\u308b\u691c\u67fb\u7bc4\u56f2<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u8fd1\u5e74\u306e\u6280\u8853\u9032\u6b69\u306b\u3088\u308a\u3001NIPT\u306f\u5f93\u6765\u306e\u4e3b\u8981\u306a\u30c8\u30ea\u30bd\u30df\u30fc\u691c\u51fa\u306b\u52a0\u3048\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u5e45\u5e83\u3044\u7570\u5e38\u3082\u5bfe\u8c61\u3068\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"8-1_%E3%83%9E%E3%82%A4%E3%82%AF%E3%83%AD%E3%82%A2%E3%83%AC%E3%82%A4%E8%A7%A3%E6%9E%90%E3%81%A8%E3%81%AE%E4%BD%B5%E7%94%A8\"><\/span><strong>8-1. \u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4\u89e3\u6790\u3068\u306e\u4f75\u7528<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u6280\u8853\u3092\u5fdc\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u5f93\u6765\u306eNIPT\u3067\u306f\u691c\u51fa\u56f0\u96e3\u3060\u3063\u305f\u5fae\u7d30\u6b20\u5931\u30fb\u91cd\u8907\uff08\u30de\u30a4\u30af\u30ed\u30c7\u30ec\u30c3\u30c8\/\u30c7\u30e5\u30d7\u30ea\u30b1\u30fc\u30b7\u30e7\u30f3\uff09\u3082\u4e00\u90e8\u691c\u51fa\u53ef\u80fd\u3067\u3059\u3002<br>\u4f8b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>22q11.2\u6b20\u5931\u75c7\u5019\u7fa4\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/microdeletion-syndrome\/\">\u30c7\u30a3\u30b8\u30e7\u30fc\u30b8\u75c7\u5019\u7fa4<\/a>\uff09<\/strong><strong><br><\/strong><\/li>\n\n\n\n<li><strong><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/1p-36-deletion-syndrome\/\">1p36\u6b20\u5931\u75c7\u5019\u7fa4<\/a><\/strong><strong><br><\/strong><\/li>\n\n\n\n<li><strong>15q11.2\u6b20\u5931\u75c7\u5019\u7fa4\uff08\u30d7\u30e9\u30c0\u30fc\u30fb\u30a6\u30a3\u30ea\u75c7\u5019\u7fa4\u3001\u30a2\u30f3\u30b8\u30a7\u30eb\u30de\u30f3\u75c7\u5019\u7fa4\uff09<\/strong><strong><br><\/strong><\/li>\n<\/ul>\n\n\n\n<p>\u305f\u3060\u3057\u3001\u3053\u308c\u3089\u306f\u611f\u5ea6\u30fb\u7279\u7570\u5ea6\u304c\u4f4e\u3081\u3067\u3001\u967d\u6027\u7d50\u679c\u304c\u51fa\u305f\u5834\u5408\u306f\u5fc5\u305a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-clinic\/amniocentesis\/\">\u7f8a\u6c34\u691c\u67fb<\/a>\u306a\u3069\u3067\u78ba\u5b9a\u8a3a\u65ad\u3092\u884c\u3046\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"8-2_%E6%80%A7%E6%9F%93%E8%89%B2%E4%BD%93%E7%95%B0%E5%B8%B8%E3%81%AE%E7%B2%BE%E5%BA%A6%E5%90%91%E4%B8%8A\"><\/span><strong>8-2. \u6027\u67d3\u8272\u4f53\u7570\u5e38\u306e\u7cbe\u5ea6\u5411\u4e0a<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u4ee5\u524d\u306fX\u30fbY\u67d3\u8272\u4f53\u306e\u6570\u7684\u7570\u5e38\u691c\u51fa\u7cbe\u5ea6\u304c\u4f4e\u3081\u3067\u3057\u305f\u304c\u3001\u6700\u65b0\u306eNGS\u6280\u8853\u3092\u7528\u3044\u305f\u89e3\u6790\u306b\u3088\u308a\u3001<strong>\u30bf\u30fc\u30ca\u30fc\u75c7\u5019\u7fa4\u3084<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/klinefelter-syndrome\/\">\u30af\u30e9\u30a4\u30f3\u30d5\u30a7\u30eb\u30bf\u30fc\u75c7\u5019\u7fa4<\/a>\u306e\u691c\u51fa\u7cbe\u5ea6\u304c\u5411\u4e0a<\/strong>\u3057\u3066\u3044\u307e\u3059\u3002<br>\u305d\u308c\u3067\u3082\u507d\u967d\u6027\u30ea\u30b9\u30af\u304c\u3042\u308b\u305f\u3081\u3001\u6027<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u967d\u6027\u4f8b\u3067\u306f\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3068\u78ba\u5b9a\u8a3a\u65ad\u304c\u5fc5\u9808\u3067\u3059\u3002<\/p>\n\n\n\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"9_NIPT%E3%81%AE%E7%B5%B1%E8%A8%88%E3%81%A8%E5%8F%97%E6%A4%9C%E7%8A%B6%E6%B3%81\"><\/span><strong>9. NIPT\u306e\u7d71\u8a08\u3068\u53d7\u691c\u72b6\u6cc1<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u65e5\u672c\u3067\u306f2013\u5e74\u4ee5\u964d\u3001NIPT\u5c0e\u5165\u65bd\u8a2d\u304c\u5897\u52a0\u3057\u3001\u5e74\u9593\u7d0410\u4e07\u4ef6\u4ee5\u4e0a\u306e\u598a\u5a66\u304c\u691c\u67fb\u3092\u53d7\u3051\u3066\u3044\u307e\u3059\u3002<br><\/li>\n\n\n\n<li>\u9ad8\u9f62\u598a\u5a66\uff0835\u6b73\u4ee5\u4e0a\uff09\u3067\u306e\u53d7\u691c\u304c\u4e2d\u5fc3\u3067\u3059\u304c\u3001\u8fd1\u5e74\u306f\u5168\u5e74\u9f62\u5c64\u3067\u306e\u5229\u7528\u304c\u62e1\u5927\u3057\u3066\u3044\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\u30ea\u30b9\u30af\u306e\u967d\u6027\u7684\u4e2d\u7387\uff08PPV\uff1aPositive Predictive Value\uff09\u306f\u3001\u6bcd\u4f53\u5e74\u9f62\u3084\u598a\u5a20\u9031\u6570\u306b\u3088\u308a\u5909\u52d5\u3057\u307e\u3059\u3002<br>\n<ul class=\"wp-block-list\">\n<li>35\u6b73\u4ee5\u4e0a\u3067\u306f\u7d0490\uff05<br><\/li>\n\n\n\n<li>30\u6b73\u524d\u5f8c\u3067\u306f\u7d0460\u301c70\uff05<br><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u53c2\u8003\u6587\u732e: Akolekar R et al., <em>Ultrasound Obstet Gynecol<\/em>, 2015;45:530-539.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"10_NIPT%E3%82%92%E5%8F%97%E3%81%91%E3%82%8B%E9%9A%9B%E3%81%AE%E5%80%AB%E7%90%86%E7%9A%84%E9%85%8D%E6%85%AE\"><\/span><strong>10. NIPT\u3092\u53d7\u3051\u308b\u969b\u306e\u502b\u7406\u7684\u914d\u616e<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>NIPT\u306f\u9ad8\u5ea6\u306a\u60c5\u5831\u3092\u3082\u305f\u3089\u3059\u4e00\u65b9\u3067\u3001<strong>\u5fc3\u7406\u7684\u30fb\u502b\u7406\u7684\u914d\u616e<\/strong>\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u967d\u6027\u7d50\u679c\u306f\u80ce\u5150\u7570\u5e38\u306e\u53ef\u80fd\u6027\u3092\u793a\u3059\u3082\u306e\u3067\u3001\u78ba\u5b9a\u8a3a\u65ad\u3067\u306f\u306a\u3044<br><\/li>\n\n\n\n<li>\u51fa\u751f\u524d\u306b\u5f97\u305f\u60c5\u5831\u304c\u598a\u5a66\u3084\u5bb6\u65cf\u306b\u5fc3\u7406\u7684\u8ca0\u62c5\u3092\u4e0e\u3048\u308b\u5834\u5408\u304c\u3042\u308b<br><\/li>\n\n\n\n<li><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u7a2e\u985e\u306b\u3088\u3063\u3066\u306f\u8efd\u5ea6\u306a\u969c\u5bb3\u3067\u7d42\u308f\u308b\u5834\u5408\u3082\u3042\u308b<br><\/li>\n\n\n\n<li>\u6027<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u60c5\u5831\u306f\u598a\u5a20\u4e2d\u306e\u9078\u629e\u306b\u5f71\u97ff\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b<br><\/li>\n<\/ul>\n\n\n\n<p>\u305d\u306e\u305f\u3081\u3001\u691c\u67fb\u524d\u5f8c\u306b\u306f<strong>\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306e\u53d7\u8a3a<\/strong>\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067\u306f\u3001\u691c\u67fb\u306e\u9650\u754c\u3084\u7d50\u679c\u306e\u89e3\u91c8\u3001\u4eca\u5f8c\u306e\u533b\u7642\u9078\u629e\u306b\u3064\u3044\u3066\u5341\u5206\u306a\u8aac\u660e\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"11_NIPT%E3%81%AE%E8%B2%BB%E7%94%A8%E3%81%A8%E4%BF%9D%E9%99%BA%E9%81%A9%E7%94%A8\"><\/span><strong>11. NIPT\u306e\u8cbb\u7528\u3068\u4fdd\u967a\u9069\u7528<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u65e5\u672c\u3067\u306eNIPT\u8cbb\u7528\u306f<strong>15\u4e07\u5186\u524d\u5f8c\u301c20\u4e07\u5186\u524d\u5f8c<\/strong>\u304c\u4e00\u822c\u7684\u3067\u3059\u3002<br><\/li>\n\n\n\n<li>\u73fe\u5728\u3001NIPT\u306f\u539f\u5247\u3068\u3057\u3066\u4fdd\u967a\u9069\u7528\u5916\u3067\u3042\u308a\u3001\u81ea\u8cbb\u8a3a\u7642\u3068\u306a\u308a\u307e\u3059\u3002<br><\/li>\n\n\n\n<li>\u9ad8\u9f62\u598a\u5a66\u3084<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u598a\u5a66\u306e\u5834\u5408\u3067\u3082\u3001\u57fa\u672c\u7684\u306b\u81ea\u8cbb\u691c\u67fb\u3067\u3059\u3002<br><\/li>\n<\/ul>\n\n\n\n<p>\u6ce8\u610f\uff1a\u8cbb\u7528\u3060\u3051\u3067\u306a\u304f\u3001\u691c\u67fb\u5f8c\u306e\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3084\u78ba\u5b9a\u8a3a\u65ad\u8cbb\u7528\u3082\u8003\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"12_NIPT%E3%81%AE%E6%A4%9C%E6%9F%BB%E9%81%B8%E6%8A%9E%E3%81%AE%E3%83%9D%E3%82%A4%E3%83%B3%E3%83%88\"><\/span><strong>12. NIPT\u306e\u691c\u67fb\u9078\u629e\u306e\u30dd\u30a4\u30f3\u30c8<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u76ee\u7684\u3092\u660e\u78ba\u306b\u3059\u308b<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4e3b\u8981\u306a\u30c8\u30ea\u30bd\u30df\u30fc\u306e\u307f\u691c\u51fa\u3057\u305f\u3044\u5834\u5408\u3068\u3001\u5fae\u7d30<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u307e\u3067\u77e5\u308a\u305f\u3044\u5834\u5408\u3067\u691c\u67fb\u65b9\u6cd5\u304c\u7570\u306a\u308b\u3002<br><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u691c\u67fb\u306e\u7cbe\u5ea6\u3092\u7406\u89e3\u3059\u308b<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>21\u30c8\u30ea\u30bd\u30df\u30fc\u306f\u9ad8\u7cbe\u5ea6\u3001\u6027<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3084\u5fae\u7d30\u6b20\u5931\u306f\u7cbe\u5ea6\u304c\u4f4e\u3044\u3002<br><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3092\u53d7\u3051\u308b<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u691c\u67fb\u524d\u5f8c\u306e\u5fc3\u7406\u7684\u8ca0\u62c5\u3084\u4eca\u5f8c\u306e\u533b\u7642\u9078\u629e\u306b\u5099\u3048\u308b\u3002<br><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u78ba\u5b9a\u8a3a\u65ad\u306e\u6e96\u5099<\/strong><strong><br><\/strong>\n<ul class=\"wp-block-list\">\n<li>\u967d\u6027\u7d50\u679c\u6642\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-clinic\/amniocentesis\/\">\u7f8a\u6c34\u691c\u67fb<\/a>\u3084<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chorionic-villus-test\/\">\u7d68\u6bdb\u691c\u67fb<\/a>\u3067\u78ba\u5b9a\u8a3a\u65ad\u3092\u884c\u3046\u3053\u3068\u3092\u7406\u89e3\u3059\u308b\u3002<br><\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"13_%E3%81%BE%E3%81%A8%E3%82%81\"><\/span><strong>13. \u307e\u3068\u3081<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>NIPT\u306f\u3001\u6bcd\u4f53\u3084\u80ce\u5150\u306b\u30ea\u30b9\u30af\u3092\u307b\u3068\u3093\u3069\u4f34\u308f\u305a\u3001\u4e3b\u8981\u306a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3092\u9ad8\u7cbe\u5ea6\u3067\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3067\u304d\u308b\u753b\u671f\u7684\u306a\u691c\u67fb\u3067\u3059\u3002\u8fd1\u5e74\u306f\u6027<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3084\u5fae\u7d30<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3082\u4e00\u90e8\u691c\u51fa\u53ef\u80fd\u3068\u306a\u308a\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u306e\u9078\u629e\u80a2\u304c\u5e83\u304c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u3001NIPT\u306f\u3042\u304f\u307e\u3067<strong>\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u691c\u67fb<\/strong>\u3067\u3042\u308a\u3001\u967d\u6027\u7d50\u679c\u306f\u78ba\u5b9a\u8a3a\u65ad\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u691c\u67fb\u524d\u5f8c\u306b\u306f\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3092\u53d7\u3051\u3001\u691c\u67fb\u306e\u9650\u754c\u3084\u4eca\u5f8c\u306e\u9078\u629e\u80a2\u3092\u5341\u5206\u306b\u7406\u89e3\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u6b63\u78ba\u306a\u60c5\u5831\u3092\u57fa\u306b\u691c\u67fb\u3092\u53d7\u3051\u308b\u3053\u3068\u3067\u3001\u598a\u5a20\u7ba1\u7406\u3084\u51fa\u751f\u524d\u8a3a\u7642\u306e\u5224\u65ad\u3092\u5b89\u5fc3\u3057\u3066\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%8F%82%E8%80%83%E6%96%87%E7%8C%AE\"><\/span><strong>\u53c2\u8003\u6587\u732e<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Bianchi DW et al., <em>N Engl J Med<\/em>, 2014;370:799-808. <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1311730\">https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1311730<\/a><br><\/li>\n\n\n\n<li>Palomaki GE et al., <em>Genet Med<\/em>, 2012;14:296-305.<a href=\"https:\/\/www.nature.com\/articles\/gim2011185\"> https:\/\/www.nature.com\/articles\/gim2011185<br><\/a><\/li>\n\n\n\n<li>Norton ME et al., <em>N Engl J Med<\/em>, 2015;372:1589-1597. <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1407349\">https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1407349<\/a><br><\/li>\n\n\n\n<li>Gil MM et al., <em>Ultrasound Obstet Gynecol<\/em>, 2015;45:530-539. <a href=\"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full\/10.1002\/uog.14803\">https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full\/10.1002\/uog.14803<\/a><br><\/li>\n\n\n\n<li>Liang D et al., <em>Prenat Diagn<\/em>, 2018;38:789-797. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pd.5326\">https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pd.5326<\/a><\/li>\n\n\n\n<li>Akolekar R et al., <em>Ultrasound Obstet Gynecol<\/em>, 2015;45:530-539. <a href=\"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full\/10.1002\/uog.14803\">https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full\/10.1002\/uog.14803<\/a><br><\/li>\n\n\n\n<li>Liang D et al., <em>Prenat Diagn<\/em>, 2018;38:789-797. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pd.5326\">https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pd.5326<\/a><br><\/li>\n\n\n\n<li>Norton ME et al., <em>N Engl J Med<\/em>, 2015;372:1589-1597. <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1407349\">https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1407349<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"\u306f\u3058\u3081\u306b \u598a\u5a20\u4e2d\u306e\u51fa\u751f\u524d\u8a3a\u65ad\u3068\u3057\u3066\u6ce8\u76ee\u3055&#8230;\n <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-chromosome-abnormality\/\">\u7d9a\u304d\u3092\u8aad\u3080<\/a>","protected":false},"author":122,"featured_media":116067,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1392],"tags":[],"class_list":["post-116062","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-1392"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/116062","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/users\/122"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/comments?post=116062"}],"version-history":[{"count":2,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/116062\/revisions"}],"predecessor-version":[{"id":116076,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/116062\/revisions\/116076"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media\/116067"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=116062"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/categories?post=116062"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/tags?post=116062"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}