{"id":116273,"date":"2025-09-25T11:38:34","date_gmt":"2025-09-25T02:38:34","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/trisomy21-nipt\/"},"modified":"2025-09-25T11:44:27","modified_gmt":"2025-09-25T02:44:27","slug":"trisomy21-nipt","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/trisomy21-nipt\/?lang=en","title":{"rendered":"Trisomy 21, the Cause of Down Syndrome, and the Detection Scope of NIPT"},"content":{"rendered":"\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/trisomy21-nipt\/?lang=en\/#1_What_Is_Down_Syndrome\" >1. What Is Down Syndrome?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/trisomy21-nipt\/?lang=en\/#2_What_Is_Trisomy_21\" >2. What Is Trisomy 21?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/trisomy21-nipt\/?lang=en\/#3_What_Is_NIPT_Non%E2%80%91Invasive_Prenatal_Testing\" >3. What Is NIPT (Non\u2011Invasive Prenatal Testing)?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/trisomy21-nipt\/?lang=en\/#4_Detection_Accuracy_of_NIPT_for_Down_Syndrome\" >4. Detection Accuracy of NIPT for Down Syndrome<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/trisomy21-nipt\/?lang=en\/#5_Limitations_of_NIPT_and_the_Need_for_Confirmatory_Diagnosis\" >5. Limitations of NIPT and the Need for Confirmatory Diagnosis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/trisomy21-nipt\/?lang=en\/#6_Ethical_Issues_of_NIPT\" >6. Ethical Issues of NIPT<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/trisomy21-nipt\/?lang=en\/#7_Early_Detection_and_Support_for_Down_Syndrome\" >7. Early Detection and Support for Down Syndrome<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/trisomy21-nipt\/?lang=en\/#8_Summary_to_Date\" >8. Summary to Date<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/trisomy21-nipt\/?lang=en\/#9_Treatment_and_Support_for_Down_Syndrome\" >9. Treatment and Support for Down Syndrome<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/trisomy21-nipt\/?lang=en\/#10_Future_Outlook_for_Individuals_with_Down_Syndrome\" >10. Future Outlook for Individuals with Down Syndrome<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/trisomy21-nipt\/?lang=en\/#11_The_Future_and_Evolution_of_NIPT\" >11. The Future and Evolution of NIPT<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/trisomy21-nipt\/?lang=en\/#12_Conclusion\" >12. Conclusion<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_What_Is_Down_Syndrome\"><\/span>1. What Is Down Syndrome?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Down syndrome (Trisomy 21) is a genetic disorder caused by an abnormality on chromosome 21. Normally, humans have two copies of chromosome 21, but individuals with Down syndrome have three copies. This abnormality usually arises from an error during chromosome segregation at fertilization. Down syndrome affects intellectual development and physical growth, and often presents characteristic physical features (e.g. flat nasal bridge, upward slanting eyes, short stature).<\/p>\n\n\n\n<p><strong>Symptoms of Down Syndrome may include:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Intellectual disability (mild to moderate)<\/li>\n\n\n\n<li>Distinct facial features (upward slanting eyes, flat nasal bridge)<\/li>\n\n\n\n<li>Congenital heart disease or gastrointestinal problems<\/li>\n\n\n\n<li>Potential issues with vision or hearing<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_What_Is_Trisomy_21\"><\/span>2. What Is Trisomy 21?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Trisomy 21 is the most common form of Down syndrome. It refers to a condition where there are three, rather than two, copies of chromosome 21. This genetic abnormality arises from errors in chromosome segregation in the egg or sperm. Trisomy 21 accounts for about 95% of all Down syndrome cases. The other cases are often due to <strong>translocation-type Down syndrome<\/strong>, in which a portion of chromosome 21 is translocated to another chromosome\u2014also a structural genetic abnormality.<\/p>\n\n\n\n<p><strong>Causes and Risk Factors of Trisomy 21 include:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The risk increases with maternal age, especially in women aged 35 or older<\/li>\n\n\n\n<li>While genetic predisposition may play a role, most cases are not inherited from parents<\/li>\n\n\n\n<li>In the majority of cases, the extra chromosome emerges sporadically, not as a hereditary trait<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_What_Is_NIPT_Non%E2%80%91Invasive_Prenatal_Testing\"><\/span>3. What Is NIPT (Non\u2011Invasive Prenatal Testing)?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> analyzes fetal DNA from maternal blood to assess the risk of chromosomal abnormalities like Down syndrome. Because it only requires a maternal blood draw (no invasive procedures), it is termed \u201cnon\u2011invasive\u201d and does not carry miscarriage risk. It is particularly noted for its very high accuracy in detecting Trisomy 21.<\/p>\n\n\n\n<p><strong>Characteristics of <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> include:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>High accuracy<\/strong>: Detection rate for Down syndrome is over 99%<\/li>\n\n\n\n<li><strong>Safety<\/strong>: As it is non\u2011invasive, there is no miscarriage risk as with amniocentesis or CVS<\/li>\n\n\n\n<li><strong><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/early-nipt-august-only\/\">Early<\/a> timing<\/strong>: Can often be performed as early as ~10 weeks of gestation<\/li>\n\n\n\n<li><strong>Low false positive rate<\/strong>: The chance of false positives is extremely low<\/li>\n<\/ul>\n\n\n\n<p><strong>Chromosomal Abnormalities Detectable by <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Trisomy 21 (Down syndrome)<\/li>\n\n\n\n<li>Trisomy 18 (Edwards syndrome)<\/li>\n\n\n\n<li>Trisomy 13 (Patau syndrome)<\/li>\n\n\n\n<li>Sex chromosome abnormalities (e.g. Turner syndrome)<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4_Detection_Accuracy_of_NIPT_for_Down_Syndrome\"><\/span>4. Detection Accuracy of NIPT for Down Syndrome<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> exhibits very high performance in detecting Down syndrome. Studies report detection (sensitivity) of over 99%, with a very low false positive rate. As a high\u2011precision screening method, <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> considerably improves upon traditional serum marker tests or NT (nuchal translucency) assessments in terms of accuracy and reliability.<\/p>\n\n\n\n<p><strong>Detection Accuracy Metrics:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Sensitivity (True Positive Rate)<\/strong>: Over 99%<\/li>\n\n\n\n<li><strong>False Positive Rate<\/strong>: About 0.1% or less<\/li>\n\n\n\n<li><strong>False Negative Rate<\/strong>: Extremely low, practically negligible<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"5_Limitations_of_NIPT_and_the_Need_for_Confirmatory_Diagnosis\"><\/span>5. Limitations of NIPT and the Need for Confirmatory Diagnosis<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Although <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> is highly precise, it remains a <strong>screening<\/strong> test, not a diagnostic one. When <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> indicates \u201chigh risk,\u201d confirmatory diagnosis via amniocentesis or CVS is still required. The final decision should be based on confirmatory testing.<\/p>\n\n\n\n<p><strong>Limitations of <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> include:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Not definitive<\/strong>: <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> evaluates risk but cannot provide a conclusive diagnosis<\/li>\n\n\n\n<li><strong>Cannot fully detect some variants<\/strong>: In cases such as translocation Down syndrome or other structural chromosomal abnormalities, <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> may not yield accurate results<\/li>\n\n\n\n<li><strong>Technical constraints<\/strong>: Rare errors in DNA analysis or low fetal DNA fraction in maternal blood, or interference from maternal factors, may affect accuracy<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"6_Ethical_Issues_of_NIPT\"><\/span>6. Ethical Issues of NIPT<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>The increasing availability of <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> has raised ethical questions in the field of prenatal diagnostics. Particularly when test results influence decisions about abortion, social, legal, and moral debates may arise. Many clinicians and experts advocate using <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> strictly as a risk assessment tool, leaving final choices to the pregnant woman and her family.<\/p>\n\n\n\n<p><strong>Key Ethical Considerations:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Selective abortion<\/strong>: Choosing pregnancy termination based on <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> results may provoke ethical concerns<\/li>\n\n\n\n<li><strong>Widespread screening<\/strong>: Whether all pregnant women should receive <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> is still debated<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"7_Early_Detection_and_Support_for_Down_Syndrome\"><\/span>7. Early Detection and Support for Down Syndrome<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/early-nipt-august-only\/\">Early<\/a> identification of Down syndrome risk allows for timely support and intervention. Through proactive medical monitoring and educational intervention, the quality of life for children with Down syndrome can significantly improve. Support strategies should be tailored case by case, and strong collaboration between families and medical teams is vital.<\/p>\n\n\n\n<p><strong>Benefits of <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/early-nipt-august-only\/\">Early<\/a> Detection Include:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Educational support<\/strong>: Special education or individualized instruction to enhance social adaptation<\/li>\n\n\n\n<li><strong>Medical support<\/strong>: <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/early-nipt-august-only\/\">Early<\/a> diagnosis and treatment of heart or gastrointestinal conditions<\/li>\n\n\n\n<li><strong>Developmental interventions<\/strong>: Physical therapy, occupational therapy, speech therapy, etc.<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/nipt\/wp-content\/uploads\/2025\/09\/23477200_s.webp\" alt=\"\u30cf\u30fc\u30c8\" class=\"wp-image-115141\"\/><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"8_Summary_to_Date\"><\/span>8. Summary to Date<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> is a valuable tool for early detection of chromosomal abnormalities (including Down syndrome) while minimizing risk to mother and fetus. However, because it is a screening tool, <strong>positive risk findings must be confirmed with diagnostic tests<\/strong> (amniocentesis or CVS). As <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> technology advances, its role in chromosomal abnormality management is becoming increasingly important, offering more choices and support to expectant mothers and families.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"9_Treatment_and_Support_for_Down_Syndrome\"><\/span>9. Treatment and Support for Down Syndrome<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Once Down syndrome is diagnosed, though it is a genetic condition that cannot be \u201ccured,\u201d early intervention and sustained support can greatly enhance quality of life. Families and medical teams should provide comprehensive care.<\/p>\n\n\n\n<p><strong>Key <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/early-nipt-august-only\/\">Early<\/a> Interventions Include:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Rehabilitation therapies<\/strong>: Physical therapy, occupational therapy, speech therapy to improve motor, language, and cognitive abilities<\/li>\n\n\n\n<li><strong>Educational support<\/strong>: Tailored special education programs or individualized instruction<\/li>\n\n\n\n<li><strong>Medical monitoring<\/strong>: Regular screening and treatment for heart, digestive, vision, hearing issues<\/li>\n\n\n\n<li><strong>Psychosocial &amp; social support<\/strong>: Family support groups, counseling, and community inclusion to reduce isolation and boost confidence<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"10_Future_Outlook_for_Individuals_with_Down_Syndrome\"><\/span>10. Future Outlook for Individuals with Down Syndrome<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>As children with Down syndrome grow into adulthood, continued support for independent living and social participation is important. Recently, efforts for adult vocational training and life-support programs have increased.<\/p>\n\n\n\n<p><strong>Support Measures May Include:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Vocational training<\/strong>: Helping adults with Down syndrome acquire skills and participate in employment<\/li>\n\n\n\n<li><strong>Life assistance services<\/strong>: Daily living support, care services to facilitate more independent lives<\/li>\n\n\n\n<li><strong>Increased social awareness<\/strong>: As society\u2019s understanding grows, schools and workplaces offer more tailored support for people with Down syndrome, opening more opportunities<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"11_The_Future_and_Evolution_of_NIPT\"><\/span>11. The Future and Evolution of NIPT<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> has revolutionized prenatal testing. Compared with traditional blood tests or ultrasound, it offers markedly higher precision and safety for both mother and fetus. In the future, <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> is expected to evolve further, enabling detection of more genetic disorders or health risks.<\/p>\n\n\n\n<p><strong>Possible Future Directions for <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/early-nipt-august-only\/\">Early<\/a> detection of diverse conditions<\/strong>: Beyond trisomy 21, 18, and 13, detecting a wider array of genetic disorders and variants<\/li>\n\n\n\n<li><strong>Use of artificial intelligence (AI)<\/strong>: AI may enhance DNA analysis, accelerate results, and improve accuracy<\/li>\n\n\n\n<li><strong>Broader applicability<\/strong>: Expanding usage to low\u2011risk pregnancies so that more women can benefit<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"12_Conclusion\"><\/span>12. Conclusion<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Down syndrome is a genetic condition caused by chromosomal abnormality, yet advances in modern medicine make early detection and support possible. Prenatal risk assessment via <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> is a high-accuracy, low-risk option. However, confirmatory testing (amniocentesis, CVS) remains necessary when needed. Once diagnosis is made, early intervention, education, and medical support significantly improve life outcomes.<\/p>\n\n\n\n<p>As <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> technology improves and its application expands, we expect it to become central in prenatal chromosomal abnormality management, offering greater choice and support for pregnant women and their families.<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"1. What Is Down Synd&#8230;\n <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/trisomy21-nipt\/?lang=en\">\u7d9a\u304d\u3092\u8aad\u3080<\/a>","protected":false},"author":122,"featured_media":116268,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[97],"tags":[],"class_list":["post-116273","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/116273","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/users\/122"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/comments?post=116273"}],"version-history":[{"count":2,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/116273\/revisions"}],"predecessor-version":[{"id":116297,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/116273\/revisions\/116297"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media\/116268"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=116273"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/categories?post=116273"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/tags?post=116273"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}