{"id":116462,"date":"2025-09-25T14:32:38","date_gmt":"2025-09-25T05:32:38","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-microdeletion-risks\/"},"modified":"2025-09-25T14:41:42","modified_gmt":"2025-09-25T05:41:42","slug":"nipt-microdeletion-risks","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-microdeletion-risks\/?lang=en","title":{"rendered":"The Hidden Risks of Chromosomal Microabnormalities"},"content":{"rendered":"\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-microdeletion-risks\/?lang=en\/#1_Introduction_Invisible_Congenital_Risks\" >1. Introduction: Invisible Congenital Risks<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-microdeletion-risks\/?lang=en\/#2_What_Are_Chromosomal_Microabnormalities\" >2. What Are Chromosomal Microabnormalities?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-microdeletion-risks\/?lang=en\/#3_Representative_Disorders_Caused_by_Microabnormalities\" >3. Representative Disorders Caused by Microabnormalities<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-microdeletion-risks\/?lang=en\/#4_What_NIPT_Can_Reveal\" >4. What NIPT Can Reveal<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-microdeletion-risks\/?lang=en\/#5_Preparing_for_Invisible_Risks\" >5. Preparing for Invisible Risks<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-microdeletion-risks\/?lang=en\/#6_Importance_of_Genetic_Counseling\" >6. Importance of Genetic Counseling<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-microdeletion-risks\/?lang=en\/#7_Ethical_and_Social_Issues\" >7. Ethical and Social Issues<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-microdeletion-risks\/?lang=en\/#8_Future_Prospects\" >8. Future Prospects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-microdeletion-risks\/?lang=en\/#9_Summary_So_Far\" >9. Summary So Far<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-microdeletion-risks\/?lang=en\/#10_When_and_How_Symptoms_Appear\" >10. When and How Symptoms Appear<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-microdeletion-risks\/?lang=en\/#11_Preparing_Before_and_After_Testing\" >11. Preparing Before and After Testing<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-microdeletion-risks\/?lang=en\/#12_Practical_Social_Support\" >12. Practical Social Support<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-microdeletion-risks\/?lang=en\/#13_Decision-Making_Process_for_Prenatal_Testing\" >13. Decision-Making Process for Prenatal Testing<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-microdeletion-risks\/?lang=en\/#14_Conclusion_Preparing_for_Invisible_Risks_Builds_Future_Security\" >14. Conclusion: Preparing for Invisible Risks Builds Future Security<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_Introduction_Invisible_Congenital_Risks\"><\/span>1. Introduction: Invisible Congenital Risks<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>The human body is composed of 46 chromosomes, containing about 20,000 genes.<br>Even small deletions or duplications of chromosomes (microabnormalities) can lead to disabilities or developmental delays that are not apparent from appearance.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>A child may look healthy but later be diagnosed with learning disabilities, developmental disorders, or mild intellectual disability.<\/li>\n\n\n\n<li>Some cases only reveal heart disease or immune abnormalities after birth.<\/li>\n<\/ul>\n\n\n\n<p>In recent years, <strong><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> (Non-Invasive Prenatal Testing)<\/strong> and analysis of microdeletion syndromes have shed light on such \u201cinvisible congenital risks.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_What_Are_Chromosomal_Microabnormalities\"><\/span>2. What Are Chromosomal Microabnormalities?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Chromosomal abnormalities are broadly divided into two categories:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Numerical abnormalities<\/strong><br>\u2002Examples: Trisomy 21 (Down syndrome), Trisomy 18, Trisomy 13<br>\u2002Caused by an increase or decrease in chromosome number<\/li>\n\n\n\n<li><strong>Structural abnormalities (including microabnormalities)<\/strong><br>\u2002Caused by deletions or duplications of chromosome segments<\/li>\n<\/ul>\n\n\n\n<p><strong>Microabnormalities (microdeletions \/ microduplications):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Small-scale abnormalities at the million-base-pair level, often undetectable with conventional karyotyping<\/li>\n\n\n\n<li>May show little to no outward features but significantly affect neurological development and organ function<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_Representative_Disorders_Caused_by_Microabnormalities\"><\/span>3. Representative Disorders Caused by Microabnormalities<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>22q11.2 Deletion Syndrome (DiGeorge Syndrome)<\/strong><br>\u2002Prevalence: about 1 in 4,000<br>\u2002Features:<br>\u2002Congenital heart defects, immune deficiency, hypocalcemia<br>\u2002Learning difficulties, mild intellectual disability, social challenges<br>\u2002Increased risk of schizophrenia in adulthood<\/li>\n\n\n\n<li><strong><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/1p-36-deletion-syndrome\/\">1p36<\/a> Deletion Syndrome<\/strong><br>\u2002Features:<br>\u2002Hypotonia, developmental delay, hearing loss<br>\u2002May present with seizures and cardiomyopathy<\/li>\n\n\n\n<li><strong>Other Microdeletion Syndromes<\/strong><br>\u200215q11-q13 deletion (Prader-Willi Syndrome)<br>\u20027q11.23 deletion (Williams Syndrome)<\/li>\n<\/ul>\n\n\n\n<p>These disorders may not present symptoms immediately after birth, making them difficult to detect based on appearance alone.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4_What_NIPT_Can_Reveal\"><\/span>4. What NIPT Can Reveal<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Traditional <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> has been focused on assessing the risk of Trisomy 21, 18, and 13.<br>Recently, optional panels can also screen for <strong>microdeletion syndromes<\/strong>.<\/p>\n\n\n\n<p><strong>Features of <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Non-invasive: analyzes fetal DNA from maternal blood<\/li>\n\n\n\n<li>Possible from 10 weeks of pregnancy<\/li>\n\n\n\n<li>Almost no risk of miscarriage<\/li>\n<\/ul>\n\n\n\n<p><strong>Limitations:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> is only a screening test; positive results require confirmatory diagnosis via amniocentesis<\/li>\n\n\n\n<li>Cannot detect all microabnormalities<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"5_Preparing_for_Invisible_Risks\"><\/span>5. Preparing for Invisible Risks<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Identifying risks prenatally offers families several benefits:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Medical preparation<\/strong><br>\u2002Plan for potential neonatal cardiac surgery or immune treatment<br>\u2002Coordinate NICU admission and perinatal care in advance<\/li>\n\n\n\n<li><strong>Psychological preparation<\/strong><br>\u2002Families can gradually process and accept possible disabilities<br>\u2002Genetic counseling helps reduce anxiety and support decision-making<\/li>\n\n\n\n<li><strong><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/early-nipt-august-only\/\">Early<\/a> access to social support<\/strong><br>\u2002Apply early for disability certificates, special child allowances, and other benefits<br>\u2002Connect with family and patient support groups sooner<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"6_Importance_of_Genetic_Counseling\"><\/span>6. Importance of Genetic Counseling<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Microabnormalities have a wide spectrum of symptoms, making it difficult to predict severity before birth.<br>Genetic counseling is therefore recommended:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Understand the accuracy and limitations of testing<\/li>\n\n\n\n<li>Clarify next steps for both positive and negative results<\/li>\n\n\n\n<li>Support decision-making aligned with family values<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"7_Ethical_and_Social_Issues\"><\/span>7. Ethical and Social Issues<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Prenatal testing for microabnormalities raises social discussions:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Selective abortion<\/strong><br>\u2002Families may face decisions even when severity cannot be predicted<\/li>\n\n\n\n<li><strong>Impact on people with disabilities<\/strong><br>\u2002Concerns that widespread testing may reinforce social prejudice<\/li>\n\n\n\n<li><strong>Fair access to information<\/strong><br>\u2002Efforts needed to reduce information gaps between families and healthcare providers<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/nipt\/wp-content\/uploads\/2025\/09\/33235246_s.webp\" alt=\"\u30cf\u30fc\u30c8\" class=\"wp-image-115985\"\/><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"8_Future_Prospects\"><\/span>8. Future Prospects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Advances in genomics will enable more precise prenatal testing<\/li>\n\n\n\n<li>Personalized medicine and early interventions may reduce symptoms and promote social participation<\/li>\n\n\n\n<li>Expanding social support and psychological care is essential<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"9_Summary_So_Far\"><\/span>9. Summary So Far<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Chromosomal microabnormalities can cause intellectual and developmental disabilities that are not outwardly visible<\/li>\n\n\n\n<li><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> offers non-invasive risk assessment to aid medical and psychological preparation<\/li>\n\n\n\n<li>Combining genetic counseling with social support is essential for safe childbirth and childrearing<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"10_When_and_How_Symptoms_Appear\"><\/span>10. When and How Symptoms Appear<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Effects of microabnormalities may be evident immediately after birth or only emerge years later.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>At birth<\/strong><br>\u2002Congenital heart defects (e.g., Tetralogy of Fallot, coarctation of the aorta)<br>\u2002Hypotonia (floppiness when held)<br>\u2002Feeding difficulties<\/li>\n\n\n\n<li><strong>In infancy<\/strong><br>\u2002Developmental delays (rolling, walking, speaking)<br>\u2002Short stature, poor weight gain<br>\u2002Seizures, recurrent infections from immune deficiency<\/li>\n\n\n\n<li><strong>In school age or later<\/strong><br>\u2002Learning disabilities (reading, writing, math difficulties)<br>\u2002Mild-to-moderate intellectual disability<br>\u2002<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/adhd-genetics-symptoms-support\/\">ADHD<\/a> or autism spectrum disorder tendencies<\/li>\n<\/ul>\n\n\n\n<p>Thus, early identification of risks and timely interventions are crucial.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"11_Preparing_Before_and_After_Testing\"><\/span>11. Preparing Before and After Testing<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>When considering prenatal testing, particularly for microabnormalities:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Before testing<\/strong><br>\u2002Understand scope, accuracy, and limitations of testing<br>\u2002Anticipate responses to positive results (amniocentesis, delivery planning)<br>\u2002Discuss as a family what would bring reassurance<\/li>\n\n\n\n<li><strong>After testing<\/strong><br>\u2002Positive: undergo confirmatory amniocentesis<br>\u2002Negative: understand it does not guarantee 100% safety; monitor development after birth<br>\u2002If anxiety is high: consult clinical psychologists or genetic counselors<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"12_Practical_Social_Support\"><\/span>12. Practical Social Support<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Families raising children with risks of intellectual or developmental disability can improve quality of life by using social programs:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Medical subsidies<\/strong> (self-support medical care, infant medical coverage)<br>\u2002Reduces costs of consultations, medications, and hospitalization<\/li>\n\n\n\n<li><strong>Disability certificates &amp; allowances<\/strong><br>\u2002Provides living support, tax deductions, and utility discounts<\/li>\n\n\n\n<li><strong>After-school and child development services<\/strong><br>\u2002Offer language, motor, and social skills training<\/li>\n\n\n\n<li><strong>Family support &amp; respite care<\/strong><br>\u2002Short-term admission or temporary childcare reduces parenting burden<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"13_Decision-Making_Process_for_Prenatal_Testing\"><\/span>13. Decision-Making Process for Prenatal Testing<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>When uncertain about undergoing testing:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Information gathering<\/strong><br>\u2002Understand mechanisms, conditions tested, and accuracy of <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> and amniocentesis<\/li>\n\n\n\n<li><strong>Family value alignment<\/strong><br>\u2002Discuss whether knowing results brings reassurance and how to respond<\/li>\n\n\n\n<li><strong>Consult healthcare providers<\/strong><br>\u2002Check appropriateness of testing with obstetricians and genetic counselors<\/li>\n\n\n\n<li><strong>Psychological preparation<\/strong><br>\u2002Seek professional mental health support if anxiety is overwhelming<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"14_Conclusion_Preparing_for_Invisible_Risks_Builds_Future_Security\"><\/span>14. Conclusion: Preparing for Invisible Risks Builds Future Security<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Chromosomal microabnormalities may cause hidden disabilities undetectable by appearance<\/li>\n\n\n\n<li><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> is a valuable entry point for risk assessment but requires confirmatory testing for diagnosis<\/li>\n\n\n\n<li>Genetic counseling, social support, and psychological preparation are key to family reassurance<\/li>\n\n\n\n<li>Preparing for invisible risks is not the \u201cend\u201d but a <strong>first step toward safe and confident parenting<\/strong><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"1. Introduction: Inv&#8230;\n <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-microdeletion-risks\/?lang=en\">\u7d9a\u304d\u3092\u8aad\u3080<\/a>","protected":false},"author":122,"featured_media":116455,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[97],"tags":[],"class_list":["post-116462","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/116462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/users\/122"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/comments?post=116462"}],"version-history":[{"count":2,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/116462\/revisions"}],"predecessor-version":[{"id":116468,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/116462\/revisions\/116468"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media\/116455"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=116462"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/categories?post=116462"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/tags?post=116462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}