{"id":116575,"date":"2025-09-25T17:12:57","date_gmt":"2025-09-25T08:12:57","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-intellectual-disability-chromosome\/"},"modified":"2025-09-25T17:21:06","modified_gmt":"2025-09-25T08:21:06","slug":"nipt-intellectual-disability-chromosome","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-intellectual-disability-chromosome\/?lang=en","title":{"rendered":"Are Developmental Disorders Different? The Link Between Intellectual Disability and Chromosomal Abnormalities"},"content":{"rendered":"\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-intellectual-disability-chromosome\/?lang=en\/#1_Introduction_The_Position_of_Developmental_Disorders_Intellectual_Disability_and_Chromosomal_Abnormalities\" >1. Introduction: The Position of Developmental Disorders, Intellectual Disability, and Chromosomal Abnormalities<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-intellectual-disability-chromosome\/?lang=en\/#2_What_Is_NIPT_Basics_and_Advances\" >2. What Is NIPT? Basics and Advances<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-intellectual-disability-chromosome\/?lang=en\/#3_Intellectual_Disability_and_Chromosomal_Abnormalities_Key_Trisomies\" >3. Intellectual Disability and Chromosomal Abnormalities: Key Trisomies<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-intellectual-disability-chromosome\/?lang=en\/#4_Partial_DeletionsDuplications_and_Their_Link_to_Intellectual_Developmental_Disabilities\" >4. Partial Deletions\/Duplications and Their Link to Intellectual &amp; Developmental Disabilities<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-intellectual-disability-chromosome\/?lang=en\/#5_What_NIPT_Can_and_Cannot_Reveal\" >5. What NIPT Can and Cannot Reveal<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-intellectual-disability-chromosome\/?lang=en\/#6_Expert_Opinions_and_Social_Significance\" >6. Expert Opinions and Social Significance<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-intellectual-disability-chromosome\/?lang=en\/#7_Differences_from_Developmental_Disorders_and_Preventing_Misconceptions\" >7. Differences from Developmental Disorders and Preventing Misconceptions<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-intellectual-disability-chromosome\/?lang=en\/#8_The_Role_of_NIPT_Professional_Perspective\" >8. The Role of NIPT: Professional Perspective<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-intellectual-disability-chromosome\/?lang=en\/#9_Recent_Advances_in_NIPT\" >9. Recent Advances in NIPT<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-intellectual-disability-chromosome\/?lang=en\/#10_Family_and_Societal_Significance_of_NIPT\" >10. Family and Societal Significance of NIPT<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-intellectual-disability-chromosome\/?lang=en\/#11_Ethical_Challenges_and_Considerations\" >11. Ethical Challenges and Considerations<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-intellectual-disability-chromosome\/?lang=en\/#12_Key_Points_Before_Testing\" >12. Key Points Before Testing<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-intellectual-disability-chromosome\/?lang=en\/#13_Future_Prospects\" >13. Future Prospects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-intellectual-disability-chromosome\/?lang=en\/#14_Conclusion\" >14. Conclusion<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_Introduction_The_Position_of_Developmental_Disorders_Intellectual_Disability_and_Chromosomal_Abnormalities\"><\/span>1. Introduction: The Position of Developmental Disorders, Intellectual Disability, and Chromosomal Abnormalities<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u201cDevelopmental disorders\u201d and \u201cintellectual disability\u201d are similar yet distinct concepts.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Developmental disorders<\/strong>: Broad conditions caused by differences in brain function, often affecting interpersonal skills, communication, and learning ability, and manifesting as lifelong cognitive or behavioral traits.<\/li>\n\n\n\n<li><strong>Intellectual disability (ID)<\/strong>: Defined by an IQ of approximately 70 or below, characterized primarily by difficulties in learning and adapting to the environment.<\/li>\n\n\n\n<li><strong>Chromosomal abnormalities<\/strong>: An important cause of both, where abnormalities in chromosome number or structure can result in severe intellectual disability and syndromes with physical features.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_What_Is_NIPT_Basics_and_Advances\"><\/span>2. What Is NIPT? Basics and Advances<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> (Non-Invasive Prenatal Testing)<\/strong> analyzes fetal DNA circulating in maternal blood to screen for chromosomal abnormalities.<br>Traditionally, <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> focused on numerical abnormalities such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Trisomy 21 (Down syndrome)<\/li>\n\n\n\n<li>Trisomy 18 (Edwards syndrome)<\/li>\n\n\n\n<li>Trisomy 13 (Patau syndrome)<\/li>\n<\/ul>\n\n\n\n<p>More recently, some <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> platforms can detect <strong>microdeletions and microduplications<\/strong>, making it possible to identify structural abnormalities related to intellectual and developmental disabilities that were previously hard to detect prenatally.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_Intellectual_Disability_and_Chromosomal_Abnormalities_Key_Trisomies\"><\/span>3. Intellectual Disability and Chromosomal Abnormalities: Key Trisomies<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Trisomy 21 (Down syndrome):<\/strong> The most well-known chromosomal abnormality. The average IQ is below 70, and moderate intellectual disability is common.<\/li>\n\n\n\n<li><strong>Trisomy 18 \/ Trisomy 13:<\/strong> Often associated with severe intellectual and physical disabilities, congenital disorders, and poor survival, with many cases resulting in miscarriage, stillbirth, or short life expectancy.<\/li>\n<\/ul>\n\n\n\n<p>These trisomies can be detected with high accuracy by <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>. If positive, confirmatory testing (e.g., amniocentesis) and genetic counseling are strongly recommended.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4_Partial_DeletionsDuplications_and_Their_Link_to_Intellectual_Developmental_Disabilities\"><\/span>4. Partial Deletions\/Duplications and Their Link to Intellectual &amp; Developmental Disabilities<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Chromosomal microstructural abnormalities (copy number variations: CNVs) have been increasingly recognized as causes of <strong>autism spectrum disorder (ASD)<\/strong> and <strong>intellectual disability<\/strong>. Examples include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/1p-36-deletion-syndrome\/\">1p36<\/a> deletion syndrome<\/li>\n\n\n\n<li>5p deletion syndrome (Cri-du-chat syndrome)<\/li>\n\n\n\n<li>15q11\u201313 deletions (Prader-Willi syndrome, Angelman syndrome)<\/li>\n<\/ul>\n\n\n\n<p>Recent <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> advancements allow detection of some of these abnormalities, enabling partial identification of chromosomal conditions linked to intellectual disability before birth.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"5_What_NIPT_Can_and_Cannot_Reveal\"><\/span>5. What NIPT Can and Cannot Reveal<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>Can detect:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Numerical abnormalities such as Trisomy 21\/18\/13<\/li>\n\n\n\n<li>Candidate conditions involving microdeletions\/microduplications<\/li>\n<\/ul>\n\n\n\n<p><strong>Cannot detect:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Developmental disorders or autism without chromosomal abnormalities<\/li>\n\n\n\n<li>Single-gene disorders or conditions caused by environmental factors<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"6_Expert_Opinions_and_Social_Significance\"><\/span>6. Expert Opinions and Social Significance<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Surveys among pediatricians show that about 90% believe <strong><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> contributes to early treatment and developmental support<\/strong>, citing benefits such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/early-nipt-august-only\/\">Early<\/a> planning of care strategies<\/li>\n\n\n\n<li>Preparing family and professional support systems<\/li>\n<\/ul>\n\n\n\n<p>However, <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> is only a <strong>screening test<\/strong>, not a diagnostic tool. Positive results require confirmatory testing (e.g., amniocentesis, karyotyping) along with genetic counseling before decisions are made.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"7_Differences_from_Developmental_Disorders_and_Preventing_Misconceptions\"><\/span>7. Differences from Developmental Disorders and Preventing Misconceptions<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>Q1. Can <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> detect developmental disorders?<\/strong><br>\u2192 No. Autism, <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/adhd-genetics-symptoms-support\/\">ADHD<\/a>, and learning disabilities often occur without chromosomal abnormalities and cannot be detected by <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>.<\/p>\n\n\n\n<p><strong>Q2. Does a positive <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> mean the child will definitely have intellectual disability?<\/strong><br>\u2192 No. For example, even with Trisomy 21, outcomes vary. Some children may fall into the borderline IQ range, not necessarily severe intellectual disability.<\/p>\n\n\n\n<p><strong>Q3. How accurate is <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>?<\/strong><br>\u2192 Negative predictive value is very high (&gt;99%), but positive predictive value varies with maternal age and other factors. Confirmatory testing is essential for positives.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"8_The_Role_of_NIPT_Professional_Perspective\"><\/span>8. The Role of NIPT: Professional Perspective<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> helps identify potential <strong>causes of intellectual or developmental disability through chromosomal abnormalities<\/strong>.<\/li>\n\n\n\n<li>It does not diagnose developmental disorders themselves.<\/li>\n\n\n\n<li>Genetic counseling, confirmatory testing, and early support planning are crucial for family decision-making.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"9_Recent_Advances_in_NIPT\"><\/span>9. Recent Advances in NIPT<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Modern <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> has evolved significantly:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Genome-wide <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>:<\/strong> Can detect aneuploidies across all autosomes (1\u201322) and sex chromosomes.<\/li>\n\n\n\n<li><strong>Microdeletion\/microduplication screening:<\/strong> Now able to detect conditions such as <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/1p-36-deletion-syndrome\/\">1p36<\/a> deletion syndrome and 22q11.2 deletion syndrome, both linked to ID\/DD.<\/li>\n\n\n\n<li><strong>Improved accuracy:<\/strong> Better technology reduces maternal DNA interference, allowing results even at low fetal fraction.<\/li>\n<\/ul>\n\n\n\n<p>This progress means risks of intellectual disability that were once only discovered postnatally can now sometimes be recognized early in pregnancy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"10_Family_and_Societal_Significance_of_NIPT\"><\/span>10. Family and Societal Significance of NIPT<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Birth preparation and childcare planning:<\/strong> <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/early-nipt-august-only\/\">Early<\/a> detection allows families to prepare for medical care and home adjustments.<\/li>\n\n\n\n<li><strong>Medical and support networks:<\/strong> Enables early coordination with NICU facilities and developmental care centers.<\/li>\n\n\n\n<li><strong>Psychological readiness:<\/strong> Families can gradually prepare for the possibility of intellectual or developmental disability.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"11_Ethical_Challenges_and_Considerations\"><\/span>11. Ethical Challenges and Considerations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Selective termination:<\/strong> Families may face difficult decisions when abnormalities are detected. The Japan Society of Obstetrics and Gynecology requires genetic counseling with <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>.<\/li>\n\n\n\n<li><strong>Avoiding misconceptions\/overexpectations:<\/strong> <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> is a screening test, not definitive. Positive results always require confirmatory diagnosis.<\/li>\n\n\n\n<li><strong>Social understanding and support:<\/strong> Wider use of <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> must be accompanied by greater awareness and expanded support systems for individuals with disabilities.<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/nipt\/wp-content\/uploads\/2025\/09\/22339071_s.webp\" alt=\"\u8d64\u3061\u3083\u3093\" class=\"wp-image-116160\"\/><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"12_Key_Points_Before_Testing\"><\/span>12. Key Points Before Testing<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Target conditions and accuracy:<\/strong> Know which abnormalities are tested and the predictive values.<\/li>\n\n\n\n<li><strong>Follow-up after positives:<\/strong> Plan for confirmatory testing and counseling.<\/li>\n\n\n\n<li><strong>Psychological support:<\/strong> Discuss with family; seek counseling if needed.<\/li>\n\n\n\n<li><strong>Reliability of testing facilities:<\/strong> Confirm accreditation and aftercare services.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"13_Future_Prospects\"><\/span>13. Future Prospects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Research is expanding into:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Single-gene and multifactorial disorders<\/strong> in prenatal evaluation<\/li>\n\n\n\n<li><strong>Integration with genomic medicine<\/strong> for personalized care and early intervention<\/li>\n\n\n\n<li><strong>Social and legal frameworks<\/strong> for ethical use and family-centered decision-making<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"14_Conclusion\"><\/span>14. Conclusion<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Developmental disorders cannot be directly detected by <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> can screen for chromosomal abnormalities associated with intellectual disability<\/li>\n\n\n\n<li>Positive cases require confirmatory testing and genetic counseling<\/li>\n\n\n\n<li>Testing has profound psychological and social implications, requiring preparation and understanding<\/li>\n<\/ul>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> is medically and socially significant, but accurate interpretation and supportive, family-centered decision-making are most important.<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"1. Introduction: The&#8230;\n <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-intellectual-disability-chromosome\/?lang=en\">\u7d9a\u304d\u3092\u8aad\u3080<\/a>","protected":false},"author":122,"featured_media":116569,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[97],"tags":[],"class_list":["post-116575","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/116575","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/users\/122"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/comments?post=116575"}],"version-history":[{"count":2,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/116575\/revisions"}],"predecessor-version":[{"id":116586,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/116575\/revisions\/116586"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media\/116569"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=116575"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/categories?post=116575"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/tags?post=116575"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}